DIL
MCID: DRG013
MIFTS: 48

Drug-Induced Lupus Erythematosus (DIL)

Categories: Bone diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Drug-Induced Lupus Erythematosus

MalaCards integrated aliases for Drug-Induced Lupus Erythematosus:

Name: Drug-Induced Lupus Erythematosus 12 58 15 71
Dile 12 58
Dil 12

Characteristics:

Orphanet epidemiological data:

58
drug-induced lupus erythematosus
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:0040093
NCIt 49 C114354
SNOMED-CT 67 80258006
ICD10 32 M32.0
ICD10 via Orphanet 33 M32.0
UMLS via Orphanet 72 C0263591
Orphanet 58 ORPHA231111
UMLS 71 C0263591

Summaries for Drug-Induced Lupus Erythematosus

Disease Ontology : 12 A lupus erythematosus caused by chronic use of certain drugs.

MalaCards based summary : Drug-Induced Lupus Erythematosus, also known as dile, is related to exanthem and bacteriuria. An important gene associated with Drug-Induced Lupus Erythematosus is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. Affiliated tissues include skin, bone and testes, and related phenotypes are dyspnea and elevated serum creatine kinase

Wikipedia : 74 Drug-induced lupus erythematosus is an autoimmune disorder (similar to systemic lupus erythematosus... more...

Related Diseases for Drug-Induced Lupus Erythematosus

Diseases related to Drug-Induced Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 643)
# Related Disease Score Top Affiliating Genes
1 exanthem 30.9 TNF IL6 IL1B IL10 H2AC18 ALB
2 bacteriuria 30.7 IL6 H2AC18 ALB
3 congestive heart failure 30.7 TNF IL6 IL1B ALB
4 aseptic meningitis 30.7 TNF IL1B IL10
5 erythema multiforme 30.7 TNF IL6 IL4
6 pericarditis 30.6 TNF IL6 IL1B ALB
7 cutaneous lupus erythematosus 30.6 TNF IL6 IL1B IL10
8 graft-versus-host disease 30.6 TNF IL6 IL1B IL10
9 polyneuropathy 30.5 TNF IL6 IL1B ALB
10 pemphigus 30.5 TNF IL6 IL4 IL10
11 arteries, anomalies of 30.5 TNF IL6 IL1B H2AC18 ALB
12 central nervous system disease 30.4 TNF IL6 IL1B H2AC18 ALB
13 nervous system disease 30.4 TNF IL6 IL1B H2AC18 DCAF8 ALB
14 autoimmune disease 30.4 TNF IL6 IL4 IL1B IL10
15 lipoprotein quantitative trait locus 30.3 TNF IL6 IL1B IL10 ALB
16 endocarditis 30.3 TNF IL6 IL10 GAPDH ALB
17 acute cystitis 30.3 TNF IL6 IL1B IL10 H2AC18 ALB
18 chronic kidney disease 30.2 TNF IL6 IL1B IL10 ALB
19 vascular disease 30.2 TNF PECAM1 IL6 IL10 GAPDH ALB
20 myocarditis 30.1 TNF PTPRC IL6 IL4 IL1B IL10
21 systemic lupus erythematosus 30.0 TNF PTPRC IL6 IL4 IL1B IL10
22 thrombocytopenia 29.9 TNF PECAM1 IL6 IL4 IL1B IL10
23 dilated cardiomyopathy 29.9 TNF PTPRC IL6 IL4 IL1B IL10
24 immune deficiency disease 29.9 TNF PTPRC IL6 IL4 IL10 H2AC18
25 inflammatory bowel disease 29.4 TNF PTPRC PECAM1 IL6 IL4 IL1B
26 lupus erythematosus 10.9
27 physiological polycythemia 10.7 TNF IL1B
28 external pathological resorption 10.7 TNF IL6
29 scorpion envenomation 10.7 TNF IL6
30 atrial standstill 1 10.6
31 systemic onset juvenile idiopathic arthritis 10.6 TNF IL1B
32 punctate inner choroidopathy 10.6 TNF IL10
33 staphylococcal toxic shock syndrome 10.6 TNF IL1B
34 fasciitis 10.6 TNF IL6 H2AC18
35 idiopathic anterior uveitis 10.6 TNF IL6
36 prosthetic joint infection 10.6 IL6 IL1B
37 periodontitis, chronic 10.6 IL6 IL1B
38 streptococcal toxic-shock syndrome 10.6 TNF IL6
39 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 TNF IL6
40 anaerobic pneumonia 10.6 TNF IL6 IL1B
41 stachybotrys chartarum 10.6 TNF IL6 IL1B
42 neurotic disorder 10.6 TNF IL6 DCAF8
43 carbuncle 10.6 TNF IL6 IL1B
44 aortitis 10.6 TNF IL6 IL1B
45 pneumonic tularemia 10.6 TNF IL6 IL1B
46 multifocal choroiditis 10.6 TNF IL10
47 vulvar vestibulitis syndrome 10.6 TNF IL1B
48 periapical periodontitis 10.6 TNF IL6 IL1B
49 laryngitis 10.6 TNF IL6 IL1B
50 kashin-beck disease 10.6 TNF IL1B

Graphical network of the top 20 diseases related to Drug-Induced Lupus Erythematosus:



Diseases related to Drug-Induced Lupus Erythematosus

Symptoms & Phenotypes for Drug-Induced Lupus Erythematosus

Human phenotypes related to Drug-Induced Lupus Erythematosus:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dyspnea 58 31 hallmark (90%) Very frequent (99-80%) HP:0002094
2 elevated serum creatine kinase 58 31 hallmark (90%) Very frequent (99-80%) HP:0003236
3 anemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001903
4 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
5 hematuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0000790
6 pericarditis 58 31 hallmark (90%) Very frequent (99-80%) HP:0001701
7 myalgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003326
8 thrombocytopenia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001873
9 petechiae 58 31 hallmark (90%) Very frequent (99-80%) HP:0000967
10 elevated c-reactive protein level 58 31 hallmark (90%) Very frequent (99-80%) HP:0011227
11 elevated erythrocyte sedimentation rate 58 31 hallmark (90%) Very frequent (99-80%) HP:0003565
12 pericardial effusion 58 31 hallmark (90%) Very frequent (99-80%) HP:0001698
13 decreased serum complement c3 58 31 hallmark (90%) Very frequent (99-80%) HP:0005421
14 antinuclear antibody positivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0003493
15 malar rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0025300
16 increased blood urea nitrogen 58 31 hallmark (90%) Very frequent (99-80%) HP:0003138
17 prolonged qtc interval 58 31 hallmark (90%) Very frequent (99-80%) HP:0005184
18 lupus anticoagulant 58 31 hallmark (90%) Very frequent (99-80%) HP:0025343
19 decreased serum complement c4 58 31 hallmark (90%) Very frequent (99-80%) HP:0045042
20 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
21 autoimmune antibody positivity 58 Very frequent (99-80%)
22 constitutional symptom 58 Occasional (29-5%)
23 serositis 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Drug-Induced Lupus Erythematosus:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 ACTB ALB AQP3 AVPR2 GAPDH IL10
2 cardiovascular system MP:0005385 10.27 ACTB ALB AQP3 DCAF8 GAPDH IL10
3 immune system MP:0005387 10.25 ACTB ALB AQP3 DCAF8 IL10 IL1B
4 hematopoietic system MP:0005397 10.2 ACTB AVPR2 DCAF8 GAPDH IL10 IL1B
5 digestive/alimentary MP:0005381 10.13 ALB AQP3 IL10 IL4 IL6 PECAM1
6 mortality/aging MP:0010768 10.1 ACTB ALB AQP3 AVPR2 GAPDH IL10
7 integument MP:0010771 10.02 AVPR2 IL10 IL1B IL4 IL6 PTPRC
8 liver/biliary system MP:0005370 10.02 ACTB ALB DCAF8 GAPDH IL10 IL4
9 neoplasm MP:0002006 9.81 ACTB ALB IL10 IL1B IL6 PTPRC
10 renal/urinary system MP:0005367 9.61 ALB AQP3 AVPR2 GAPDH IL4 IL6
11 respiratory system MP:0005388 9.23 AQP3 IL10 IL4 IL6 PECAM1 PTPRC

Drugs & Therapeutics for Drug-Induced Lupus Erythematosus

Search Clinical Trials , NIH Clinical Center for Drug-Induced Lupus Erythematosus

Genetic Tests for Drug-Induced Lupus Erythematosus

Anatomical Context for Drug-Induced Lupus Erythematosus

MalaCards organs/tissues related to Drug-Induced Lupus Erythematosus:

40
Skin, Bone, Testes, Smooth Muscle, Cervix, Skeletal Muscle

Publications for Drug-Induced Lupus Erythematosus

Articles related to Drug-Induced Lupus Erythematosus:

(show top 50) (show all 159)
# Title Authors PMID Year
1
Discoid drug-induced lupus erythematosus induced by antitumor necrosis factor agents is a very rare subtype of cutaneous lupus: Three cases and literature review. 61
32239589 2020
2
Discoid Lupus Erythematosus Lesions Associated with Systemic Fluorouracil Agents: A Case Report and Review. 61
32467803 2020
3
Acute interstitial nephritis and drug-induced systemic lupus erythematosus due to chlorthalidone and amiodarone: A case report. 61
32166031 2020
4
Response to: 'Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1' by Michot et al and 'Checkpoint inhibitor-associated immune arthritis' by Arnaud et al. 61
29934372 2019
5
Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1. 61
29858173 2019
6
Carbamazepine-induced systemic lupus erythematosus: A case-based review. 61
30388076 2019
7
When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus. 61
30613100 2019
8
Lamotrigine-induced Systemic Lupus Erythematosus: A Diagnostic Dilemma. 61
30505789 2018
9
Hydralazine-associated vasculitis: Overlapping features of drug-induced lupus and vasculitis. 61
29519741 2018
10
Drug-induced lupus erythematosus: an update on drugs and mechanisms. 61
29870500 2018
11
Drug-induced lupus erythematosus secondary to pirfenidone. 61
29266198 2018
12
Drug-induced Subacute Cutaneous Lupus Erythematosus Caused by a Topical Beta Blocker - Timolol. 61
29782299 2018
13
[Secukinumab-induced subacute-cutaneous lupus erythematosus]. 61
29075868 2018
14
Drug-Induced Lupus Erythematosus Associated with Antiretroviral Therapy in a Patient with Human Immunodeficiency Virus: A Case Report. 61
29147636 2017
15
Drug-Induced by Systemic Lupus Erythematosus Presenting as Recurrent Pericardial Effusion After Mitral Valve Repair. 61
29202555 2017
16
Drug-induced lupus erythematosus mimicking lymphoma on 18F-FDG-PET/CT. 61
28420045 2017
17
A case of lupus-like syndrome in a patient receiving adalimumab and a brief review of the literature on drug-induced lupus erythematosus. 61
28191663 2017
18
[Relationship between the environmental factors and the CPUE (catch per unit effort) of Pseudocarcharias kamoharai in tropical Atlantic Ocean based on the GAM-Tweedie model]. 61
29745167 2017
19
A case of drug-induced lupus erythematosus secondary to trimethoprim/sulfamethoxazole presenting with pleural effusions and pericardial tamponade. 61
27357280 2017
20
Treatment of antiviral-resistant recurrent erythema multiforme with dapsone. 61
27860166 2017
21
Drug-induced systemic lupus erythematosus in a child after 3 years of treatment with carbamazepine. 61
26424435 2017
22
Hydralazine Induced Lupus Syndrome Presenting with Recurrent Pericardial Effusion and a Negative Antinuclear Antibody. 61
28194293 2017
23
ANA-Negative Hydralazine-Induced Pericardial Effusion. 61
29391867 2017
24
Isoniazid Induced Lupus Presenting as Oral Mucosal Ulcers with Pancytopenia. 61
27891378 2016
25
Coexistence of Fetal Cardiac Malformation and Maternal Drug-Induced Lupus: Is Lamotrigine Safe? 61
26418583 2016
26
A simple estimation of ideal profile of essential amino acids and metabolizable energy for growing Japanese quail. 61
26671312 2016
27
A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production. 61
26408002 2015
28
Drug-induced lupus erythematosus associated with donepezil: a case report. 61
26420637 2015
29
Spondyloarthropathy in inflammatory bowel disease patients on TNF inhibitors. 61
26337851 2015
30
Adalimumab-Induced Cutaneous Lupus Erythematosus in a 16-Year-Old Girl with Juvenile Idiopathic Arthritis. 61
25845414 2015
31
Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia. 61
26710505 2015
32
Systemic lupus erythematosus in Crohn's disease: drug-induced or idiopathic? 61
26126856 2015
33
Isoniazid in autoimmunity: a trigger for multiple sclerosis? 61
25342979 2014
34
Drug-induced lupus erythematosus. 61
24819757 2014
35
Hydralazine-induced toxic epidermal necrolysis in a patient on continuous ambulatory peritoneal dialysis. 61
24588409 2014
36
Autoantibodies in psoriatic patients treated with anti-TNF-α therapy. 61
24797746 2014
37
Drug-induced lupus: Including anti-tumour necrosis factor and interferon induced. 61
24557776 2014
38
Drug-induced lupus erythematosus presenting with cardiac tamponade: a case report and literature review. 61
24373757 2014
39
Drug-induced lupus erythematosus. 61
23164669 2014
40
Drug-induced subacute cutaneous lupus erythematosus associated with nab-paclitaxel therapy. 61
24155645 2013
41
Vasotocin analogues with selective natriuretic, kaliuretic and antidiuretic effects in rats. 61
23835093 2013
42
Tumor necrosis factor-α antagonists: Side effects and their management. 61
23974693 2013
43
[Development of lupus erythematosus during infliximab therapy]. 61
23567877 2013
44
An unexpected side-effect of a commonly used drug. 61
24282922 2013
45
Hydralazine-induced ANCA vasculitis with pulmonary renal syndrome: a rare clinical presentation. 61
21590349 2012
46
Drug-induced lupus erythematosus with emphasis on skin manifestations and the role of anti-TNFα agents. 61
22937775 2012
47
Hydralazine-induced pulmonary-renal syndrome: a case report. 61
20724911 2012
48
Systemic lupus erythematosus induced by interferon β1 therapy in a patient with multiple sclerosis. 61
21323997 2012
49
Sweet syndrome associated with hydralazine-induced lupus erythematosus. 61
22530328 2012
50
Wilson's disease treated with penicillamine and lupus erythematosus: related or distinct entities? 61
22350045 2012

Variations for Drug-Induced Lupus Erythematosus

Expression for Drug-Induced Lupus Erythematosus

Search GEO for disease gene expression data for Drug-Induced Lupus Erythematosus.

Pathways for Drug-Induced Lupus Erythematosus

Pathways related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 TNF PTPRC IL6 IL4 IL1B IL10
2
Show member pathways
12.84 TNF IL6 IL4 IL1B IL10 ACTB
3
Show member pathways
12.59 TNF PTPRC IL6 IL4 IL1B IL10
4
Show member pathways
12.58 TNF IL6 IL4 IL1B IL10
5 12.54 TNF PTPRC PECAM1 IL4 IL1B IL10
6
Show member pathways
12.32 TNF IL6 IL4 IL1B
7
Show member pathways
12.32 TNF IL6 IL4 IL1B ALB
8 12.26 TNF IL6 IL1B GAPDH ACTB
9
Show member pathways
12.25 TNF IL4 IL1B IL10
10
Show member pathways
12.25 TNF IL6 IL4 IL1B IL10
11 12.22 TNF IL6 IL1B IL10
12
Show member pathways
12.2 TNF IL6 IL1B IL10
13 12.2 TNF PTPRC IL6 IL1B GAPDH ACTB
14
Show member pathways
12.18 TNF IL6 IL4 IL1B
15 12.08 TNF PECAM1 IL1B ACTB
16 12.01 TNF IL6 IL4 IL1B
17 12 TNF IL6 IL1B IL10 ACTB
18 11.97 TNF PTPRC IL6 IL4 IL10
19 11.95 TNF IL6 IL4 IL1B IL10
20
Show member pathways
11.94 TNF IL6 IL1B IL10
21 11.94 TNF TLX3 IL6 IL1B IL10 GAPDH
22 11.91 TNF IL6 IL1B IL10
23 11.9 TNF IL6 IL4 IL1B
24 11.77 TNF IL6 IL1B IL10
25 11.67 TNF PTPRC IL4 IL1B IL10
26 11.66 TNF IL6 IL4 IL1B
27
Show member pathways
11.65 TNF IL6 IL1B
28 11.6 TNF IL6 IL1B
29 11.59 TNF PTPRC IL6 IL1B IL10
30 11.51 TNF IL1B ACTB
31 11.48 TNF IL6 IL1B
32 11.35 TNF IL6 IL1B IL10
33 11.3 TNF IL6 IL1B IL10
34 11.29 TNF IL6 IL1B
35 11.25 TNF PECAM1 IL6 IL1B IL10
36 11.24 TNF IL6 IL4 IL1B
37 11.04 TNF IL6 IL4 IL1B IL10
38 11.01 TNF SPON2 IL6 IL4 IL1B IL10
39 10.79 IL6 IL4 IL1B
40 10.48 TNF IL6 IL4 IL1B IL10

GO Terms for Drug-Induced Lupus Erythematosus

Cellular components related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 TNF SPON2 PECAM1 IL6 IL4 IL1B

Biological processes related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.18 TNF TLX3 PRDM10 IL6 IL4 IL1B
2 immune response GO:0006955 10.06 TNF IL6 IL4 IL1B IL10
3 positive regulation of gene expression GO:0010628 10.06 TNF IL6 IL4 IL1B AVPR2
4 cytokine-mediated signaling pathway GO:0019221 9.93 TNF IL6 IL4 IL1B IL10
5 B cell differentiation GO:0030183 9.84 PTPRC IL4 IL10
6 response to glucocorticoid GO:0051384 9.82 TNF IL6 IL10
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.78 TNF IL6 IL1B IL10
8 cellular response to lipopolysaccharide GO:0071222 9.72 TNF SPON2 IL6 IL1B IL10
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 TNF PECAM1 IL6 IL4
10 positive regulation of cytokine secretion GO:0050715 9.7 TNF IL10 GAPDH
11 positive regulation of JAK-STAT cascade GO:0046427 9.69 TNF IL6 IL10
12 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.67 IL4 IL10
13 maintenance of permeability of blood-brain barrier GO:0035633 9.67 PECAM1 IL6 ACTB
14 positive regulation of isotype switching to IgG isotypes GO:0048304 9.65 PTPRC IL4
15 positive regulation of MHC class II biosynthetic process GO:0045348 9.65 IL4 IL10
16 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
17 regulation of establishment of endothelial barrier GO:1903140 9.63 TNF IL1B
18 endothelial cell apoptotic process GO:0072577 9.63 TNF IL10
19 negative regulation of neurogenesis GO:0050768 9.63 TNF IL6 IL1B
20 positive regulation of mononuclear cell migration GO:0071677 9.62 TNF IL4
21 type 2 immune response GO:0042092 9.62 IL4 IL10
22 negative regulation of cytokine production involved in immune response GO:0002719 9.61 TNF IL10
23 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
24 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
25 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.6 TNF PTPRC
26 negative regulation of cytokine secretion involved in immune response GO:0002740 9.59 TNF IL10
27 regulation of isotype switching GO:0045191 9.58 IL4 IL10
28 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 TNF IL1B
30 receptor biosynthetic process GO:0032800 9.56 TNF IL10
31 positive regulation of T cell proliferation GO:0042102 9.56 PTPRC IL6 IL4 IL1B
32 positive regulation of T cell mediated immunity GO:0002711 9.55 PTPRC IL1B
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 TNF IL1B IL10
34 positive regulation of chemokine biosynthetic process GO:0045080 9.33 TNF IL4 IL1B
35 positive regulation of neuroinflammatory response GO:0150078 9.13 TNF IL6 IL1B
36 positive regulation of interleukin-6 production GO:0032755 8.92 TNF SPON2 IL6 IL1B

Molecular functions related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL6 IL4 IL1B IL10

Sources for Drug-Induced Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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