MCID: DRG004
MIFTS: 30

Drug-Induced Mental Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Drug-Induced Mental Disorder

MalaCards integrated aliases for Drug-Induced Mental Disorder:

Name: Drug-Induced Mental Disorder 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1203
ICD9CM 36 292.8 292.89
UMLS 74 C0154325

Summaries for Drug-Induced Mental Disorder

MalaCards based summary : Drug-Induced Mental Disorder is related to schizoid personality disorder and hypoactive sexual desire disorder. An important gene associated with Drug-Induced Mental Disorder is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian entrainment. Affiliated tissues include myeloid and cerebellum, and related phenotypes are Decreased viability after Maraba virus infection and Decreased viability after Maraba virus infection

Related Diseases for Drug-Induced Mental Disorder

Diseases related to Drug-Induced Mental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 schizoid personality disorder 10.4 HTR1A HTR2A
2 hypoactive sexual desire disorder 10.4 HTR1A HTR2A
3 schizophrenia 5 10.4 HTR1A HTR2A
4 substance-induced psychosis 10.3 DRD2 HTR1A HTR2A
5 periodic limb movement disorder 10.3 DRD2 HTR1A HTR2A
6 psychosexual disorder 10.3 HTR1A HTR2A
7 bipolar i disorder 10.3 DRD1 HTR1A HTR2A
8 generalized anxiety disorder 10.3 DRD2 HTR1A HTR2A
9 tardive dyskinesia 10.3 DRD2 DRD3 HTR2A
10 delusional disorder 10.3 DRD2 DRD3 DRD4
11 impulse control disorder 10.3 DRD2 DRD3 DRD4
12 conduct disorder 10.3 DRD2 DRD4 DRD5
13 polysubstance abuse 10.3 CNR1 DRD2 DRD3
14 schizoaffective disorder 10.3 DRD2 DRD3 HTR2A
15 anxiety 10.2 CNR1 HTR1A HTR2A
16 post-traumatic stress disorder 10.2 CNR1 DRD2 HTR2A
17 drug dependence 10.2 CNR1 DRD2 DRD3
18 gilles de la tourette syndrome 10.2 DRD2 DRD4 DRD5
19 personality disorder 10.2 DRD2 DRD4 HTR1A HTR2A
20 bruxism 10.2 DRD2 DRD3 DRD5 HTR2A
21 tic disorder 10.2 DRD2 DRD4 DRD5 HTR2A
22 migraine without aura 10.2 DRD2 DRD3 DRD4 HTR1A
23 bipolar disorder 10.2 DRD2 DRD3 HTR1A HTR2A
24 movement disease 10.2 DRD2 DRD3 PINK1
25 specific developmental disorder 10.2 CNR1 DRD4 DRD5
26 early-onset schizophrenia 10.2 DRD1 DRD2 HTR2A NDUFS4
27 alcoholic psychosis 10.1 DRD2 HTR2A
28 substance abuse 10.1 DRD2 DRD3 DRD4 DRD5
29 interval angle-closure glaucoma 10.1 IDH1 IDH2
30 adult oligodendroglioma 10.1 IDH1 IDH2
31 enchondroma 10.1 IDH1 IDH2
32 intracranial chondrosarcoma 10.1 IDH1 IDH2
33 cytogenetically normal acute myeloid leukemia 10.1 IDH1 IDH2
34 pathological gambling 10.1 DRD1 DRD2 DRD3 DRD4 HTR2A
35 mood disorder 10.0 DRD2 DRD3 DRD4 HTR1A HTR2A
36 chondroblastic osteosarcoma 10.0 IDH1 IDH2
37 major depressive disorder 10.0 DRD2 DRD3 DRD4 HTR1A HTR2A
38 multiple enchondromatosis, maffucci type 10.0 IDH1 IDH2
39 intraductal papilloma 10.0 IDH1 IDH2
40 substance dependence 10.0 CNR1 DRD2 DRD3 DRD4 DRD5
41 pilocytic astrocytoma of cerebellum 10.0 IDH1 IDH2
42 spindle cell hemangioma 10.0 IDH1 IDH2
43 psychotic disorder 9.9 DRD1 DRD2 DRD3 DRD4 HTR1A HTR2A
44 obsessive-compulsive disorder 9.9 DRD1 DRD2 DRD3 DRD4 HTR1A HTR2A
45 periosteal chondrosarcoma 9.9 IDH1 IDH2
46 bursitis 9.9 NDUFS4 PHB2
47 alcohol abuse 9.9 CNR1 DRD1 DRD2 DRD3 DRD4 HTR2A
48 alcohol dependence 9.8 CNR1 DRD1 DRD2 DRD3 DRD4 HTR1A
49 schizophrenia 9.6 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
50 migraine with or without aura 1 9.6 CNR1 DRD2 DRD3 DRD5 FOS HTR1A

Graphical network of the top 20 diseases related to Drug-Induced Mental Disorder:



Diseases related to Drug-Induced Mental Disorder

Symptoms & Phenotypes for Drug-Induced Mental Disorder

GenomeRNAi Phenotypes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability after Maraba virus infection GR00252-A-1 9.83 CNR1 DRD1 DRD3 EPHA5 HTR2A PINK1
2 Decreased viability after Maraba virus infection GR00252-A-2 9.83 CNR1 DRD1 DRD3 EPHA5 PINK1
3 Decreased viability after Maraba virus infection GR00252-A-3 9.83 DRD1 EPHA5 HTR2A PINK1
4 shRNA abundance <= 50% GR00343-S 9.44 DRD1 DRD2 DRD3 DRD4 DUSP26 EPHA5

MGI Mouse Phenotypes related to Drug-Induced Mental Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
2 homeostasis/metabolism MP:0005376 9.77 CNR1 DRD1 DRD2 DRD3 DRD4 DUSP26
3 nervous system MP:0003631 9.36 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5

Drugs & Therapeutics for Drug-Induced Mental Disorder

Search Clinical Trials , NIH Clinical Center for Drug-Induced Mental Disorder

Genetic Tests for Drug-Induced Mental Disorder

Anatomical Context for Drug-Induced Mental Disorder

MalaCards organs/tissues related to Drug-Induced Mental Disorder:

42
Myeloid, Cerebellum

Publications for Drug-Induced Mental Disorder

Variations for Drug-Induced Mental Disorder

Expression for Drug-Induced Mental Disorder

Search GEO for disease gene expression data for Drug-Induced Mental Disorder.

Pathways for Drug-Induced Mental Disorder

Pathways related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
2
Show member pathways
12.8 DRD1 DRD2 DRD3 DRD4 DRD5 FOS
3
Show member pathways
12.58 DRD1 DRD2 DRD3 DRD4 DRD5 FOS
4
Show member pathways
12.36 CNR1 DRD1 GABRR3 NDUFS4
6 12.08 DRD1 DRD2 DRD3 DRD4 DRD5
7 11.98 DRD1 DRD2 DRD5 FOS HTR1A
8
Show member pathways
11.95 DRD1 DRD2 DRD4 DRD5
9
Show member pathways
11.78 DRD1 DRD2 FOS
10
Show member pathways
11.71 DRD2 DRD3 DRD4
11 11.68 CNR1 DRD3 DRD4 HTR2A
12 11.62 DRD1 DRD2 HTR2A
13
Show member pathways
11.21 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1A
14
Show member pathways
10.62 IDH1 IDH2
15 10.6 DRD1 DRD2 DRD3 DRD5

GO Terms for Drug-Induced Mental Disorder

Cellular components related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.85 DRD2 DRD4 EPHA5 HTR1A HTR2A
2 axon GO:0030424 9.77 CNR1 DRD2 EPHA5 HTR2A PINK1
3 glutamatergic synapse GO:0098978 9.63 CNR1 DRD1 DRD2 DRD3 DRD4 HTR2A
4 ciliary membrane GO:0060170 9.61 DRD1 DRD2 DRD5
5 integral component of postsynaptic membrane GO:0099055 9.58 DRD1 DRD2 HTR2A
6 GABA-ergic synapse GO:0098982 9.56 CNR1 DRD1 DRD2 DRD3
7 non-motile cilium GO:0097730 9.5 DRD1 DRD2 DRD5
8 dopaminergic synapse GO:0098691 9.49 DRD2 DRD3
9 integral component of plasma membrane GO:0005887 9.32 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
10 integral component of presynaptic membrane GO:0099056 9.26 CNR1 DRD1 DRD2 HTR2A
11 membrane GO:0016020 10.35 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5

Biological processes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.9 CNR1 DRD2 DRD3
2 cellular calcium ion homeostasis GO:0006874 9.9 DRD3 DRD4 DRD5 HTR2A
3 locomotory behavior GO:0007626 9.89 DRD1 DRD2 DRD3
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 DRD2 HTR2A PHB2
5 memory GO:0007613 9.88 CNR1 DRD1 HTR2A
6 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.86 CNR1 DRD2 DRD3
7 regulation of synaptic vesicle exocytosis GO:2000300 9.85 DRD1 DRD2 HTR2A
8 visual learning GO:0008542 9.84 DRD1 DRD2 DRD3
9 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.81 DRD4 HTR1A HTR2A
10 associative learning GO:0008306 9.81 DRD1 DRD2 DRD5
11 behavioral fear response GO:0001662 9.8 DRD1 DRD4 HTR1A
12 response to morphine GO:0043278 9.8 CNR1 DRD2 DRD3
13 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.8 CNR1 DRD1 DRD4 HTR1A HTR2A
14 arachidonic acid secretion GO:0050482 9.77 DRD2 DRD3 DRD4
15 temperature homeostasis GO:0001659 9.76 DRD1 DRD2 HTR2A
16 negative regulation of blood pressure GO:0045776 9.76 CNR1 DRD2 DRD3 DRD5
17 negative regulation of protein secretion GO:0050709 9.75 DRD2 DRD3 DRD4
18 2-oxoglutarate metabolic process GO:0006103 9.74 IDH1 IDH2
19 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.73 DRD2 DRD3
20 positive regulation of kinase activity GO:0033674 9.73 DRD4 HTR2A
21 transmission of nerve impulse GO:0019226 9.73 DRD1 DRD5
22 long-term synaptic depression GO:0060292 9.73 DRD1 DRD5
23 striatum development GO:0021756 9.73 DRD1 DRD2
24 prepulse inhibition GO:0060134 9.73 DRD1 DRD2 DRD3
25 grooming behavior GO:0007625 9.72 DRD1 DRD2
26 positive regulation of renal sodium excretion GO:0035815 9.72 DRD2 DRD3
27 regulation of synaptic transmission, GABAergic GO:0032228 9.72 CNR1 DRD2
28 G protein-coupled receptor internalization GO:0002031 9.72 DRD2 DRD3
29 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.72 DRD1 DRD3 DRD5
30 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.71 DRD3 DRD4
31 sleep GO:0030431 9.71 FOS HTR2A
32 peristalsis GO:0030432 9.71 DRD1 DRD2
33 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.71 DRD2 DRD3 DRD4
34 behavior GO:0007610 9.7 HTR1A HTR2A
35 behavioral response to ethanol GO:0048149 9.7 DRD2 DRD4
36 NADP metabolic process GO:0006739 9.7 IDH1 IDH2
37 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.7 DRD2 HTR2A
38 regulation of dopamine metabolic process GO:0042053 9.7 DRD1 DRD4 HTR1A
39 negative regulation of voltage-gated calcium channel activity GO:1901386 9.69 DRD2 DRD4
40 serotonin receptor signaling pathway GO:0007210 9.69 HTR1A HTR2A
41 mating behavior GO:0007617 9.69 DRD1 DRD5
42 cellular response to catecholamine stimulus GO:0071870 9.68 DRD1 DRD5
43 cerebral cortex GABAergic interneuron migration GO:0021853 9.68 DRD1 DRD2
44 conditioned taste aversion GO:0001661 9.67 DRD1 FOS
45 isocitrate metabolic process GO:0006102 9.67 IDH1 IDH2
46 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.67 DRD1 DRD2 DRD5
47 dopamine receptor signaling pathway GO:0007212 9.67 DRD1 DRD2 DRD3 DRD4
48 negative regulation of dopamine receptor signaling pathway GO:0060160 9.66 DRD2 DRD3
49 acid secretion GO:0046717 9.65 DRD2 DRD3
50 negative regulation of dopamine secretion GO:0033602 9.65 CNR1 DRD2

Molecular functions related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.92 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
2 neurotransmitter receptor activity GO:0030594 9.67 DRD4 HTR1A HTR2A
3 G protein-coupled serotonin receptor activity GO:0004993 9.65 DRD4 HTR1A HTR2A
4 drug binding GO:0008144 9.55 CNR1 DRD2 DRD3 DRD4 HTR2A
5 G-protein alpha-subunit binding GO:0001965 9.54 DRD1 DRD5 HTR2A
6 adrenergic receptor activity GO:0004935 9.52 DRD2 DRD3
7 serotonin binding GO:0051378 9.51 HTR1A HTR2A
8 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.46 DRD1 DRD5
9 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.43 IDH1 IDH2
10 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.43 DRD2 DRD3 DRD4
11 isocitrate dehydrogenase activity GO:0004448 9.4 IDH1 IDH2
12 dopamine binding GO:0035240 9.35 DRD1 DRD2 DRD3 DRD4 DRD5
13 dopamine neurotransmitter receptor activity GO:0004952 9.02 DRD1 DRD2 DRD3 DRD4 DRD5

Sources for Drug-Induced Mental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
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38 KEGG
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45 MeSH
46 MESH via Orphanet
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50 NCI
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52 NDF-RT
55 NINDS
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58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
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75 UMLS via Orphanet
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