MCID: DRG004
MIFTS: 24

Drug-Induced Mental Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Drug-Induced Mental Disorder

MalaCards integrated aliases for Drug-Induced Mental Disorder:

Name: Drug-Induced Mental Disorder 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1203
ICD9CM 34 292.8
UMLS 71 C0154325

Summaries for Drug-Induced Mental Disorder

MalaCards based summary : Drug-Induced Mental Disorder is related to early-onset schizophrenia and traumatic brain injury. An important gene associated with Drug-Induced Mental Disorder is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Peptide ligand-binding receptors and Beta-Adrenergic Signaling. Related phenotype is shRNA abundance <= 50%.

Related Diseases for Drug-Induced Mental Disorder

Diseases related to Drug-Induced Mental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 early-onset schizophrenia 10.4 DRD2 DRD1
2 traumatic brain injury 10.3 DRD2 COMT
3 brain injury 10.3 DRD2 COMT
4 opioid addiction 10.3 DRD2 COMT
5 conversion disorder 10.2 HTR2A COMT
6 hypoactive sexual desire disorder 10.2 HTR2A HTR1A
7 trichotillomania 10.2 DRD4 DRD3 DRD2
8 cocaine abuse 10.2 DRD3 DRD2 DRD1
9 psychosexual disorder 10.2 HTR2A HTR1A
10 focal dystonia 10.2 DRD5 DRD2 DRD1
11 atypical depressive disorder 10.2 HTR2A HTR1A
12 hypochondriasis 10.2 HTR2A HTR1A
13 adjustment disorder 10.1 HTR2A HTR1A
14 schizotypal personality disorder 10.1 DRD4 DRD2 COMT
15 neurotic disorder 10.1 HTR2A HTR1A
16 oppositional defiant disorder 10.1 DRD4 DRD2 COMT
17 serotonin syndrome 10.1 HTR2A HTR1A
18 capgras syndrome 10.1 HTR2A ADAMTS2
19 hyperprolactinemia 10.1 HTR2A DRD4 DRD2
20 obsessive-compulsive personality disorder 10.1 HTR2A DRD3 COMT
21 melancholia 10.1 HTR2A HTR1A
22 brunner syndrome 10.1 HTR2A COMT
23 alexithymia 10.1 HTR1A DRD2 COMT
24 phobia, specific 10.1 HTR1A COMT
25 social phobia 10.1 HTR1A DRD2 COMT
26 striatonigral degeneration 10.0 DRD2 DRD1
27 agoraphobia 10.0 HTR2A HTR1A COMT
28 premature ejaculation 10.0 HTR1A COMT
29 endogenous depression 10.0 HTR2A HTR1A COMT
30 tardive dyskinesia 10.0 HTR2A DRD3 DRD2 COMT
31 amphetamine abuse 10.0 DRD5 DRD4 CNR1
32 kleptomania 10.0 HTR1A DRD4 DRD3 DRD2
33 dyslexia 10.0 DRD4 DRD3 DRD2
34 supranuclear palsy, progressive, 1 10.0 DRD5 DRD2 ADAMTS2
35 heroin dependence 10.0 DRD4 DRD2 DRD1 COMT
36 chronic fatigue syndrome 10.0 HTR2A HTR1A COMT
37 conduct disorder 9.9 DRD5 DRD4 DRD2 COMT
38 cyclothymic disorder 9.9 HTR2A DRD4 DRD2 COMT
39 antisocial personality disorder 9.9 HTR2A DRD4 DRD2 COMT
40 narcolepsy 9.9 HTR2A DRD2 DRD1 COMT
41 intermittent explosive disorder 9.9 HTR2A HTR1A DRD2 COMT
42 phobic disorder 9.9 HTR2A HTR1A DRD2 COMT
43 borderline personality disorder 9.9 HTR2A HTR1A DRD2 COMT
44 oculogyric crisis 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
45 chronic tic disorder 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
46 night blindness, congenital stationary, type 1h 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
47 opioid abuse 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
48 charcot-marie-tooth disease, dominant intermediate f 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
49 generalized anxiety disorder 9.9 HTR2A HTR1A DRD2 COMT
50 choreatic disease 9.8 DRD5 DRD4 DRD3 DRD2 DRD1

Graphical network of the top 20 diseases related to Drug-Induced Mental Disorder:



Diseases related to Drug-Induced Mental Disorder

Symptoms & Phenotypes for Drug-Induced Mental Disorder

GenomeRNAi Phenotypes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.23 ADAMTS2 CABP1 COMT DRD1 DRD2 DRD4

Drugs & Therapeutics for Drug-Induced Mental Disorder

Search Clinical Trials , NIH Clinical Center for Drug-Induced Mental Disorder

Genetic Tests for Drug-Induced Mental Disorder

Anatomical Context for Drug-Induced Mental Disorder

Publications for Drug-Induced Mental Disorder

Articles related to Drug-Induced Mental Disorder:

# Title Authors PMID Year
1
[Disorder of train of thought in the elderly]. 61
24261209 2013

Variations for Drug-Induced Mental Disorder

Expression for Drug-Induced Mental Disorder

Search GEO for disease gene expression data for Drug-Induced Mental Disorder.

Pathways for Drug-Induced Mental Disorder

Pathways related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 LHB HTR2A HTR1A DRD5 DRD4 DRD3
2
Show member pathways
12.55 DRD5 DRD4 DRD3 DRD2 DRD1
3
Show member pathways
12.47 DRD5 DRD4 DRD3 DRD2 DRD1 COMT
5 12.01 DRD5 DRD4 DRD3 DRD2 DRD1
6 11.89 LHB HTR1A DRD5 DRD2 DRD1
7 11.86 LHB DRD5 DRD1
8
Show member pathways
11.72 DRD4 DRD2 DRD1
9 11.71 HTR2A DRD4 DRD3 CNR1
10
Show member pathways
11.68 DRD4 DRD3 DRD2
11 11.6 HTR2A DRD2 DRD1
12
Show member pathways
11.54 HTR2A HTR1A DRD5 DRD4 DRD3 DRD2
13 10.98 HTR2A HTR1A
14
Show member pathways
10.53 HTR1A DRD5 DRD4 DRD3 DRD2 DRD1

GO Terms for Drug-Induced Mental Disorder

Cellular components related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.21 RILPL1 HTR2A HTR1A DRD5 DRD4 DRD3
2 cell GO:0005623 10 SPICE1 HTR2A DRD5 DRD4 DRD3 DRD2
3 integral component of plasma membrane GO:0005887 9.97 HTR2A HTR1A DRD5 DRD4 DRD3 DRD2
4 axon GO:0030424 9.85 HTR2A DRD2 COMT CNR1
5 cilium GO:0005929 9.84 RILPL1 DRD5 DRD2 DRD1
6 dendrite GO:0030425 9.8 HTR2A HTR1A DRD4 DRD2 DRD1 COMT
7 dendritic spine GO:0043197 9.73 DRD2 DRD1 COMT
8 ciliary membrane GO:0060170 9.67 DRD5 DRD2 DRD1
9 integral component of postsynaptic membrane GO:0099055 9.65 HTR2A DRD2 DRD1
10 non-motile cilium GO:0097730 9.58 DRD5 DRD2 DRD1
11 GABA-ergic synapse GO:0098982 9.56 DRD3 DRD2 DRD1 CNR1
12 9+0 non-motile cilium GO:0097731 9.52 DRD5 DRD1
13 dopaminergic synapse GO:0098691 9.51 DRD3 DRD2
14 integral component of presynaptic membrane GO:0099056 9.46 HTR2A DRD2 DRD1 CNR1
15 glutamatergic synapse GO:0098978 9.43 HTR2A DRD4 DRD3 DRD2 DRD1 CNR1
16 synapse GO:0045202 9.23 HTR2A HTR1A DRD5 DRD3 DRD2 DRD1

Biological processes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.28 LHB HTR2A HTR1A DRD5 DRD4 DRD3
2 G protein-coupled receptor signaling pathway GO:0007186 10.18 LHB HTR2A HTR1A DRD5 DRD4 DRD3
3 response to drug GO:0042493 10.04 HTR2A DRD3 DRD2 DRD1 COMT
4 chemical synaptic transmission GO:0007268 10 HTR2A HTR1A DRD5 DRD4
5 cell-cell signaling GO:0007267 10 LHB DRD5 DRD3 DRD2 DRD1
6 cellular calcium ion homeostasis GO:0006874 9.92 HTR2A DRD5 DRD4 DRD3
7 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.91 DRD5 DRD1 CNR1
8 response to ethanol GO:0045471 9.9 DRD3 DRD2 CNR1
9 locomotory behavior GO:0007626 9.89 DRD3 DRD2 DRD1
10 memory GO:0007613 9.89 HTR2A DRD1 CNR1
11 learning GO:0007612 9.87 DRD3 DRD1 COMT
12 regulation of synaptic vesicle exocytosis GO:2000300 9.87 HTR2A DRD2 DRD1
13 visual learning GO:0008542 9.86 DRD3 DRD2 DRD1
14 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.85 DRD3 DRD2 DRD1
15 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.85 DRD5 DRD3 DRD2 DRD1 CNR1
16 regulation of dopamine secretion GO:0014059 9.84 HTR2A DRD3 DRD2
17 associative learning GO:0008306 9.83 DRD5 DRD2 DRD1
18 behavioral fear response GO:0001662 9.83 HTR1A DRD4 DRD1
19 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.83 HTR2A HTR1A DRD4
20 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.83 HTR2A HTR1A DRD4 DRD1 CNR1
21 response to morphine GO:0043278 9.82 DRD3 DRD2 CNR1
22 negative regulation of protein secretion GO:0050709 9.81 DRD4 DRD3 DRD2
23 negative regulation of blood pressure GO:0045776 9.81 DRD5 DRD3 DRD2 CNR1
24 arachidonic acid secretion GO:0050482 9.8 DRD4 DRD3 DRD2
25 temperature homeostasis GO:0001659 9.79 HTR2A DRD2 DRD1
26 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.78 DRD5 DRD3 DRD2 DRD1
27 negative regulation of voltage-gated calcium channel activity GO:1901386 9.77 DRD4 DRD3 DRD2
28 prepulse inhibition GO:0060134 9.77 DRD3 DRD2 DRD1
29 response to cocaine GO:0042220 9.77 DRD5 DRD3 DRD2 DRD1 CNR1
30 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.76 HTR2A DRD3 DRD2
31 behavioral response to ethanol GO:0048149 9.75 DRD4 DRD3 DRD2
32 adult walking behavior GO:0007628 9.74 DRD2 DRD1
33 negative regulation of adenylate cyclase activity GO:0007194 9.74 DRD3 DRD2
34 transmission of nerve impulse GO:0019226 9.74 DRD5 DRD1
35 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.74 DRD5 DRD3 DRD1
36 negative regulation of cytosolic calcium ion concentration GO:0051481 9.73 DRD3 DRD2
37 long-term synaptic depression GO:0060292 9.73 DRD5 DRD1
38 regulation of synaptic transmission, GABAergic GO:0032228 9.73 DRD2 CNR1
39 behavior GO:0007610 9.73 HTR2A HTR1A
40 regulation of dopamine metabolic process GO:0042053 9.73 HTR1A DRD4 DRD1
41 positive regulation of renal sodium excretion GO:0035815 9.72 DRD3 DRD2
42 grooming behavior GO:0007625 9.72 DRD2 DRD1
43 G protein-coupled receptor internalization GO:0002031 9.72 DRD3 DRD2
44 striatum development GO:0021756 9.72 DRD2 DRD1
45 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.72 DRD4 DRD3
46 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.72 DRD4 DRD3 DRD2
47 response to amphetamine GO:0001975 9.72 DRD5 DRD4 DRD3 DRD2 DRD1
48 regulation of potassium ion transport GO:0043266 9.71 DRD3 DRD2
49 peristalsis GO:0030432 9.71 DRD2 DRD1
50 serotonin receptor signaling pathway GO:0007210 9.71 HTR2A HTR1A

Molecular functions related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.92 HTR2A HTR1A DRD5 DRD4 DRD3 DRD2
2 drug binding GO:0008144 9.65 HTR2A DRD4 DRD3 DRD2 CNR1
3 neurotransmitter receptor activity GO:0030594 9.63 HTR2A HTR1A DRD4
4 G protein-coupled serotonin receptor activity GO:0004993 9.61 HTR2A HTR1A DRD4
5 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.54 DRD4 DRD3 DRD2
6 serotonin binding GO:0051378 9.48 HTR2A HTR1A
7 adrenergic receptor activity GO:0004935 9.46 DRD5 DRD3 DRD2 DRD1
8 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.4 DRD5 DRD1
9 dopamine binding GO:0035240 9.35 DRD5 DRD4 DRD3 DRD2 DRD1
10 dopamine neurotransmitter receptor activity GO:0004952 9.02 DRD5 DRD4 DRD3 DRD2 DRD1

Sources for Drug-Induced Mental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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