MCID: DRG004
MIFTS: 27

Drug-Induced Mental Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Drug-Induced Mental Disorder

MalaCards integrated aliases for Drug-Induced Mental Disorder:

Name: Drug-Induced Mental Disorder 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1203
ICD9CM 35 292.8 292.89
UMLS 73 C0154325

Summaries for Drug-Induced Mental Disorder

MalaCards based summary : Drug-Induced Mental Disorder is related to schizoid personality disorder and hypoactive sexual desire disorder. An important gene associated with Drug-Induced Mental Disorder is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Serotonergic synapse and GPCRs, Other. Affiliated tissues include cerebellum and myeloid, and related phenotypes are shRNA abundance <= 50% and behavior/neurological

Related Diseases for Drug-Induced Mental Disorder

Diseases related to Drug-Induced Mental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 schizoid personality disorder 10.3 HTR1A HTR2A
2 hypoactive sexual desire disorder 10.3 HTR1A HTR2A
3 tic disorder 10.2 DRD2 HTR2A
4 tendinitis 10.2 LHB PHB2
5 bursitis 10.2 NDUFS4 PHB2
6 tardive dyskinesia 10.2 DRD2 HTR2A
7 anxiety 10.2 CNR1 HTR1A HTR2A
8 polysubstance abuse 10.2 CNR1 DRD2
9 alcoholic psychosis 10.2 DRD2 HTR2A
10 social phobia 10.1 DRD2 HTR1A
11 atypical depressive disorder 10.1 HTR2A HTR7
12 rumination disorder 10.1 HTR1A HTR7
13 substance-induced psychosis 10.1 DRD2 HTR1A HTR2A
14 interval angle-closure glaucoma 10.1 IDH1 IDH2
15 periodic limb movement disorder 10.1 DRD2 HTR1A HTR2A
16 pathological gambling 10.1 DRD2 HTR2A
17 adult oligodendroglioma 10.1 IDH1 IDH2
18 enchondroma 10.1 IDH1 IDH2
19 personality disorder 10.1 DRD2 HTR1A HTR2A
20 intracranial chondrosarcoma 10.1 IDH1 IDH2
21 generalized anxiety disorder 10.1 DRD2 HTR1A HTR2A
22 cytogenetically normal acute myeloid leukemia 10.1 IDH1 IDH2
23 coronary artery vasospasm 10.1 HTR2A HTR7
24 chondroblastic osteosarcoma 10.1 IDH1 IDH2
25 mood disorder 10.1 DRD2 HTR1A HTR2A
26 multiple enchondromatosis, maffucci type 10.1 IDH1 IDH2
27 psychotic disorder 10.1 DRD2 HTR1A HTR2A
28 intraductal papilloma 10.1 IDH1 IDH2
29 alexithymia 10.1 DRD2 HTR1A
30 pilocytic astrocytoma of cerebellum 10.1 IDH1 IDH2
31 early-onset schizophrenia 10.1 DRD2 HTR2A NDUFS4
32 obsessive-compulsive disorder 10.1 DRD2 HTR1A HTR2A
33 spindle cell hemangioma 10.1 IDH1 IDH2
34 central nervous system disease 10.1 CNR1 HTR2A PINK1
35 post-traumatic stress disorder 10.1 CNR1 DRD2 HTR2A
36 dysthymic disorder 10.1 HTR2A HTR7
37 alcohol abuse 10.1 CNR1 DRD2 HTR2A
38 periosteal chondrosarcoma 10.1 IDH1 IDH2
39 neuroleptic malignant syndrome 10.1 DRD2 HTR1A
40 glioma susceptibility 1 10.1 IDH1 IDH2
41 kleptomania 10.1 HTR1A HTR7
42 adult astrocytic tumour 10.1 IDH1 IDH2
43 psychosexual disorder 10.1 HTR1A HTR2A HTR7
44 mental depression 10.0 HTR1A HTR2A HTR7
45 fibrillary astrocytoma 10.0 IDH1 IDH2
46 endogenous depression 10.0 HTR1A HTR2A HTR7
47 diffuse infiltrative lymphocytosis syndrome 10.0 IDH1 IDH2
48 amnestic disorder 10.0 CNR1 HTR1A HTR7
49 undifferentiated pleomorphic sarcoma 10.0 IDH1 IDH2
50 intermittent explosive disorder 10.0 HTR1A HTR7

Graphical network of the top 20 diseases related to Drug-Induced Mental Disorder:



Diseases related to Drug-Induced Mental Disorder

Symptoms & Phenotypes for Drug-Induced Mental Disorder

GenomeRNAi Phenotypes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.28 DRD2 DUSP26 EPHA5 FOS HTR1A HTR2A

MGI Mouse Phenotypes related to Drug-Induced Mental Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 CNR1 DRD2 FOS HTR1A HTR2A HTR7
2 homeostasis/metabolism MP:0005376 9.85 CNR1 DRD2 DUSP26 FOS HTR1A HTR7
3 skeleton MP:0005390 9.5 CNR1 DRD2 FOS HTR2A IDH1 NDUFS4
4 taste/olfaction MP:0005394 8.8 CNR1 DRD2 PINK1

Drugs & Therapeutics for Drug-Induced Mental Disorder

Search Clinical Trials , NIH Clinical Center for Drug-Induced Mental Disorder

Genetic Tests for Drug-Induced Mental Disorder

Anatomical Context for Drug-Induced Mental Disorder

MalaCards organs/tissues related to Drug-Induced Mental Disorder:

41
Cerebellum, Myeloid

Publications for Drug-Induced Mental Disorder

Variations for Drug-Induced Mental Disorder

Expression for Drug-Induced Mental Disorder

Search GEO for disease gene expression data for Drug-Induced Mental Disorder.

Pathways for Drug-Induced Mental Disorder

GO Terms for Drug-Induced Mental Disorder

Cellular components related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.8 CNR1 IDH1 IDH2 NDUFS4 PHB2 PINK1
2 integral component of plasma membrane GO:0005887 9.73 CNR1 DRD2 EPHA5 HTR1A HTR2A HTR7
3 mitochondrial outer membrane GO:0005741 9.54 CNR1 PHB2 PINK1
4 dendrite GO:0030425 9.35 DRD2 EPHA5 HTR1A HTR2A HTR7
5 integral component of presynaptic membrane GO:0099056 9.33 CNR1 DRD2 HTR2A
6 axon GO:0030424 9.02 CNR1 DRD2 EPHA5 HTR2A PINK1

Biological processes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.99 CNR1 DRD2 HTR1A HTR2A HTR7 LHB
2 aging GO:0007568 9.76 CNR1 FOS HTR2A
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 DRD2 EPHA5 HTR2A PHB2
4 tricarboxylic acid cycle GO:0006099 9.61 IDH1 IDH2
5 response to morphine GO:0043278 9.61 CNR1 DRD2
6 cAMP-mediated signaling GO:0019933 9.6 EPHA5 NDUFS4
7 negative regulation of blood pressure GO:0045776 9.59 CNR1 DRD2
8 response to light stimulus GO:0009416 9.58 DRD2 FOS
9 temperature homeostasis GO:0001659 9.57 DRD2 HTR2A
10 2-oxoglutarate metabolic process GO:0006103 9.56 IDH1 IDH2
11 behavioral response to cocaine GO:0048148 9.55 DRD2 HTR2A
12 vasoconstriction GO:0042310 9.54 HTR1A HTR7
13 regulation of synaptic transmission, GABAergic GO:0032228 9.52 CNR1 DRD2
14 sleep GO:0030431 9.49 FOS HTR2A
15 behavior GO:0007610 9.48 HTR1A HTR2A
16 NADP metabolic process GO:0006739 9.46 IDH1 IDH2
17 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.43 DRD2 HTR2A
18 serotonin receptor signaling pathway GO:0007210 9.4 HTR1A HTR2A
19 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.33 HTR1A HTR2A HTR7
20 isocitrate metabolic process GO:0006102 9.32 IDH1 IDH2
21 negative regulation of dopamine secretion GO:0033602 9.26 CNR1 DRD2
22 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2
23 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 8.92 CNR1 HTR1A HTR2A HTR7

Molecular functions related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.8 CNR1 DRD2 HTR1A HTR2A HTR7
2 drug binding GO:0008144 9.5 CNR1 DRD2 HTR2A
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.43 IDH1 IDH2
4 neurotransmitter receptor activity GO:0030594 9.43 HTR1A HTR2A HTR7
5 serotonin binding GO:0051378 9.37 HTR1A HTR2A
6 G protein-coupled serotonin receptor activity GO:0004993 9.33 HTR1A HTR2A HTR7
7 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
8 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Drug-Induced Mental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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