MCID: DRG004
MIFTS: 26

Drug-Induced Mental Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Drug-Induced Mental Disorder

MalaCards integrated aliases for Drug-Induced Mental Disorder:

Name: Drug-Induced Mental Disorder 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1203
ICD9CM 34 292.8 292.89
UMLS 71 C0154325

Summaries for Drug-Induced Mental Disorder

MalaCards based summary : Drug-Induced Mental Disorder is related to early-onset schizophrenia and kleptomania. An important gene associated with Drug-Induced Mental Disorder is DRD2 (Dopamine Receptor D2), and among its related pathways/superpathways are Peptide ligand-binding receptors and Beta-Adrenergic Signaling. Affiliated tissues include brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Drug-Induced Mental Disorder

Diseases related to Drug-Induced Mental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 early-onset schizophrenia 10.4 DRD2 DRD1
2 kleptomania 10.3 HTR1A DRD2
3 obsessive-compulsive personality disorder 10.3 HTR2A DRD3
4 opioid addiction 10.3 DRD2 COMT
5 hypoactive sexual desire disorder 10.2 HTR2A HTR1A
6 traumatic brain injury 10.2 DRD2 COMT
7 brain injury 10.2 DRD2 COMT
8 somatization disorder 10.2 HTR2A HTR1A
9 cyclothymic disorder 10.2 HTR2A DRD4 DRD2
10 psychosexual disorder 10.2 HTR2A HTR1A
11 schizotypal personality disorder 10.2 DRD4 DRD2 COMT
12 atypical depressive disorder 10.2 HTR2A HTR1A
13 hyperprolactinemia 10.2 HTR2A DRD4 DRD2
14 alcoholic psychosis 10.1 SLC6A3 HTR2A
15 hypochondriasis 10.1 HTR2A HTR1A
16 fibromyalgia 10.1 HTR2A DRD2 COMT
17 sexual disorder 10.1 HTR2A HTR1A DRD2
18 alexithymia 10.1 HTR1A DRD2 COMT
19 pedophilia 10.1 RILPL1 DRD2
20 social phobia 10.1 HTR1A DRD2 COMT
21 inhibited male orgasm 10.1 SLC6A3 HTR1A
22 neurotic disorder 10.1 HTR2A HTR1A
23 opioid abuse 10.1 DRD5 DRD3 DRD2 DRD1
24 striatonigral degeneration 10.1 SLC6A3 DRD2 DRD1
25 serotonin syndrome 10.0 HTR2A HTR1A
26 brunner syndrome 10.0 HTR2A HTR1A COMT
27 phobic disorder 10.0 HTR2A HTR1A COMT
28 agoraphobia 10.0 HTR2A HTR1A COMT
29 ideomotor apraxia 10.0 BCHE ADAMTS2
30 anosognosia 10.0 BCHE ADAMTS2
31 melancholia 10.0 HTR2A HTR1A
32 endogenous depression 10.0 HTR2A HTR1A COMT
33 separation anxiety disorder 10.0 SLC6A3 DRD4
34 chronic fatigue syndrome 10.0 HTR2A HTR1A COMT
35 nominal aphasia 10.0 BCHE ADAMTS2
36 tardive dyskinesia 10.0 HTR2A DRD3 DRD2 COMT
37 migraine with aura 10.0 SLC6A3 HTR2A DRD2
38 neuroleptic malignant syndrome 9.9 HTR2A HTR1A DRD3 DRD2
39 bulimia nervosa 9.9 HTR2A DRD4 DRD2 COMT
40 essential tremor 9.9 SLC6A3 DRD3 COMT
41 schizophrenia 5 9.9 HTR2A HTR1A DRD2 COMT
42 paraphilia disorder 9.9 RILPL1 ADAMTS2
43 premature ejaculation 9.9 SLC6A3 HTR1A COMT
44 idiopathic corneal edema 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
45 phobia, specific 9.9 HTR1A COMT
46 periodic limb movement disorder 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
47 lingual-facial-buccal dyskinesia 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
48 chronic tic disorder 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
49 choreatic disease 9.9 DRD5 DRD4 DRD3 DRD2 DRD1
50 capgras syndrome 9.9 HTR2A BCHE ADAMTS2

Graphical network of the top 20 diseases related to Drug-Induced Mental Disorder:



Diseases related to Drug-Induced Mental Disorder

Symptoms & Phenotypes for Drug-Induced Mental Disorder

MGI Mouse Phenotypes related to Drug-Induced Mental Disorder:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 CNR1 COMT DRD1 DRD2 DRD3 DRD4
2 homeostasis/metabolism MP:0005376 9.73 BCHE CNR1 COMT DRD1 DRD2 DRD3
3 nervous system MP:0003631 9.28 CNR1 COMT DRD1 DRD2 DRD3 DRD4

Drugs & Therapeutics for Drug-Induced Mental Disorder

Search Clinical Trials , NIH Clinical Center for Drug-Induced Mental Disorder

Genetic Tests for Drug-Induced Mental Disorder

Anatomical Context for Drug-Induced Mental Disorder

MalaCards organs/tissues related to Drug-Induced Mental Disorder:

40
Brain

Publications for Drug-Induced Mental Disorder

Articles related to Drug-Induced Mental Disorder:

# Title Authors PMID Year
1
[Disorder of train of thought in the elderly]. 61
24261209 2013

Variations for Drug-Induced Mental Disorder

Expression for Drug-Induced Mental Disorder

Search GEO for disease gene expression data for Drug-Induced Mental Disorder.

Pathways for Drug-Induced Mental Disorder

Pathways related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 LHB HTR2A HTR1A DRD5 DRD4 DRD3
2
Show member pathways
12.61 DRD5 DRD4 DRD3 DRD2 DRD1
3
Show member pathways
12.47 SLC6A3 DRD5 DRD4 DRD3 DRD2 DRD1
4 12.12 DRD5 DRD4 DRD3 DRD2 DRD1
6 12.05 LHB HTR1A DRD5 DRD2 DRD1
7
Show member pathways
12 DRD5 DRD4 DRD2 DRD1
8 11.9 LHB DRD5 DRD1
9
Show member pathways
11.8 SLC6A3 DRD2 DRD1
10 11.74 HTR2A DRD4 DRD3 CNR1
11
Show member pathways
11.72 DRD4 DRD3 DRD2
12 11.64 HTR2A DRD2 DRD1
13
Show member pathways
11.54 HTR2A HTR1A DRD5 DRD4 DRD3 DRD2
14
Show member pathways
11.05 SLC6A3 COMT BCHE
15 11.01 HTR2A HTR1A
16 10.8 DRD5 DRD3 DRD2 DRD1
17
Show member pathways
10.59 SLC6A3 HTR1A DRD5 DRD4 DRD3 DRD2

GO Terms for Drug-Induced Mental Disorder

Cellular components related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.25 SLC6A3 RILPL1 HTR2A HTR1A DRD5 DRD4
2 cell GO:0005623 10 SPICE1 HTR2A DRD5 DRD4 DRD3 DRD2
3 axon GO:0030424 9.88 SLC6A3 HTR2A DRD2 COMT CNR1
4 dendrite GO:0030425 9.88 HTR2A HTR1A DRD4 DRD2 DRD1 COMT
5 cilium GO:0005929 9.83 RILPL1 DRD5 DRD2 DRD1
6 glutamatergic synapse GO:0098978 9.73 HTR2A DRD4 DRD3 DRD2 DRD1 CNR1
7 dendritic spine GO:0043197 9.71 DRD2 DRD1 COMT
8 ciliary membrane GO:0060170 9.67 DRD5 DRD2 DRD1
9 GABA-ergic synapse GO:0098982 9.67 DRD3 DRD2 DRD1 CNR1
10 non-motile cilium GO:0097730 9.61 DRD5 DRD2 DRD1
11 integral component of plasma membrane GO:0005887 9.61 SLC6A3 HTR2A HTR1A DRD5 DRD4 DRD3
12 dopaminergic synapse GO:0098691 9.5 SLC6A3 DRD3 DRD2
13 integral component of postsynaptic membrane GO:0099055 9.46 SLC6A3 HTR2A DRD2 DRD1
14 integral component of presynaptic membrane GO:0099056 9.02 SLC6A3 HTR2A DRD2 DRD1 CNR1

Biological processes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.29 LHB HTR2A HTR1A DRD5 DRD4 DRD3
2 G protein-coupled receptor signaling pathway GO:0007186 10.22 LHB HTR2A HTR1A DRD5 DRD4 DRD3
3 response to drug GO:0042493 10.02 SLC6A3 HTR2A DRD3 DRD2 DRD1 COMT
4 chemical synaptic transmission GO:0007268 10.01 HTR2A HTR1A DRD5 DRD4
5 response to ethanol GO:0045471 9.95 SLC6A3 DRD3 DRD2 CNR1
6 cellular calcium ion homeostasis GO:0006874 9.93 HTR2A DRD5 DRD4 DRD3
7 locomotory behavior GO:0007626 9.92 SLC6A3 DRD3 DRD2 DRD1
8 memory GO:0007613 9.9 HTR2A DRD1 CNR1
9 learning GO:0007612 9.89 DRD3 DRD1 COMT BCHE
10 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.89 HTR2A HTR1A DRD4 DRD1 CNR1
11 regulation of synaptic vesicle exocytosis GO:2000300 9.87 HTR2A DRD2 DRD1
12 visual learning GO:0008542 9.87 DRD3 DRD2 DRD1
13 response to nicotine GO:0035094 9.86 SLC6A3 DRD2 CNR1
14 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.86 DRD3 DRD2 DRD1
15 regulation of dopamine secretion GO:0014059 9.85 HTR2A DRD3 DRD2
16 negative regulation of blood pressure GO:0045776 9.85 DRD5 DRD3 DRD2 CNR1
17 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.85 DRD5 DRD3 DRD2 DRD1 CNR1
18 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.84 HTR2A HTR1A DRD4
19 associative learning GO:0008306 9.84 DRD5 DRD2 DRD1
20 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.84 DRD5 DRD3 DRD2 DRD1
21 behavioral fear response GO:0001662 9.83 HTR1A DRD4 DRD1
22 response to morphine GO:0043278 9.83 DRD3 DRD2 CNR1
23 arachidonic acid secretion GO:0050482 9.82 DRD4 DRD3 DRD2
24 dopamine receptor signaling pathway GO:0007212 9.81 DRD4 DRD3 DRD2 DRD1
25 negative regulation of protein secretion GO:0050709 9.8 DRD4 DRD3 DRD2
26 temperature homeostasis GO:0001659 9.8 HTR2A DRD2 DRD1
27 negative regulation of voltage-gated calcium channel activity GO:1901386 9.79 DRD4 DRD3 DRD2
28 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.78 HTR2A DRD3 DRD2
29 behavioral response to ethanol GO:0048149 9.77 DRD4 DRD3 DRD2
30 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.76 DRD5 DRD3 DRD1
31 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.75 DRD4 DRD3 DRD2
32 negative regulation of adenylate cyclase activity GO:0007194 9.74 DRD3 DRD2
33 positive regulation of kinase activity GO:0033674 9.74 HTR2A DRD4
34 response to iron ion GO:0010039 9.74 SLC6A3 DRD2
35 negative regulation of cytosolic calcium ion concentration GO:0051481 9.74 DRD3 DRD2
36 transmission of nerve impulse GO:0019226 9.74 DRD5 DRD1
37 long-term synaptic depression GO:0060292 9.74 DRD5 DRD1
38 positive regulation of renal sodium excretion GO:0035815 9.73 DRD3 DRD2
39 regulation of synaptic transmission, GABAergic GO:0032228 9.73 DRD2 CNR1
40 grooming behavior GO:0007625 9.73 DRD2 DRD1
41 G protein-coupled receptor internalization GO:0002031 9.73 DRD3 DRD2
42 striatum development GO:0021756 9.73 DRD2 DRD1
43 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.73 DRD4 DRD3
44 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.73 DRD3 DRD2 DRD1
45 prepulse inhibition GO:0060134 9.73 SLC6A3 DRD3 DRD2 DRD1
46 regulation of potassium ion transport GO:0043266 9.72 DRD3 DRD2
47 behavior GO:0007610 9.72 HTR2A HTR1A
48 peristalsis GO:0030432 9.72 DRD2 DRD1
49 dopamine catabolic process GO:0042420 9.72 SLC6A3 COMT
50 response to amphetamine GO:0001975 9.72 DRD5 DRD4 DRD3 DRD2 DRD1

Molecular functions related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.92 HTR2A HTR1A DRD5 DRD4 DRD3 DRD2
2 neurotransmitter receptor activity GO:0030594 9.63 HTR2A HTR1A DRD4
3 drug binding GO:0008144 9.63 SLC6A3 HTR2A DRD4 DRD3 DRD2 CNR1
4 G protein-coupled serotonin receptor activity GO:0004993 9.61 HTR2A HTR1A DRD4
5 adrenergic receptor activity GO:0004935 9.56 DRD5 DRD3 DRD2 DRD1
6 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.54 DRD4 DRD3 DRD2
7 serotonin binding GO:0051378 9.48 HTR2A HTR1A
8 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.4 DRD5 DRD1
9 dopamine neurotransmitter receptor activity GO:0004952 9.35 DRD5 DRD4 DRD3 DRD2 DRD1
10 dopamine binding GO:0035240 9.1 SLC6A3 DRD5 DRD4 DRD3 DRD2 DRD1

Sources for Drug-Induced Mental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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