MCID: DRG004
MIFTS: 26

Drug-Induced Mental Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Drug-Induced Mental Disorder

MalaCards integrated aliases for Drug-Induced Mental Disorder:

Name: Drug-Induced Mental Disorder 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1203
ICD9CM 35 292.8 292.89
UMLS 73 C0154325

Summaries for Drug-Induced Mental Disorder

MalaCards based summary : Drug-Induced Mental Disorder is related to schizoid personality disorder and hypoactive sexual desire disorder. An important gene associated with Drug-Induced Mental Disorder is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Serotonergic synapse and GPCRs, Other. Related phenotypes are shRNA abundance <= 50% and behavior/neurological

Related Diseases for Drug-Induced Mental Disorder

Diseases related to Drug-Induced Mental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 schizoid personality disorder 10.9 HTR1A HTR2A
2 hypoactive sexual desire disorder 10.9 HTR1A HTR2A
3 substance-induced psychosis 10.9 HTR1A HTR2A
4 tendinitis 10.5 LHB PHB2
5 tardive dyskinesia 10.5 DRD2 HTR2A
6 alcoholic psychosis 10.5 DRD2 HTR2A
7 bursitis 10.5 NDUFS4 PHB2
8 polysubstance abuse 10.5 CNR1 DRD2
9 anxiety 10.5 CNR1 HTR1A HTR2A
10 social phobia 10.5 DRD2 HTR1A
11 rumination disorder 10.4 HTR1A HTR7
12 periodic limb movement disorder 10.4 DRD2 HTR1A HTR2A
13 interval angle-closure glaucoma 10.4 IDH1 IDH2
14 generalized anxiety disorder 10.4 DRD2 HTR1A HTR2A
15 personality disorder 10.3 DRD2 HTR1A HTR2A
16 coronary artery vasospasm 10.3 HTR2A HTR7
17 adult oligodendroglioma 10.3 IDH1 IDH2
18 enchondroma 10.3 IDH1 IDH2
19 intracranial chondrosarcoma 10.3 IDH1 IDH2
20 cytogenetically normal acute myeloid leukemia 10.3 IDH1 IDH2
21 mood disorder 10.3 DRD2 HTR1A HTR2A
22 chondroblastic osteosarcoma 10.3 IDH1 IDH2
23 obsessive-compulsive disorder 10.3 DRD2 HTR1A HTR2A
24 pathological gambling 10.3 DRD2 HTR2A
25 intraductal papilloma 10.3 IDH1 IDH2
26 multiple enchondromatosis, maffucci type 10.3 IDH1 IDH2
27 post-traumatic stress disorder 10.3 CNR1 DRD2 HTR2A
28 alexithymia 10.3 DRD2 HTR1A
29 early-onset schizophrenia 10.3 DRD2 HTR2A NDUFS4
30 pilocytic astrocytoma of cerebellum 10.3 IDH1 IDH2
31 spindle cell hemangioma 10.2 IDH1 IDH2
32 dysthymic disorder 10.2 HTR2A HTR7
33 glioma susceptibility 1 10.2 IDH1 IDH2
34 neuroleptic malignant syndrome 10.2 DRD2 HTR1A
35 periosteal chondrosarcoma 10.2 IDH1 IDH2
36 psychosexual disorder 10.2 HTR1A HTR2A HTR7
37 mental depression 10.2 HTR1A HTR2A HTR7
38 adult astrocytic tumour 10.2 IDH1 IDH2
39 kleptomania 10.1 HTR1A HTR7
40 fibrillary astrocytoma 10.1 IDH1 IDH2
41 tic disorder 10.1 DRD2 HTR2A
42 undifferentiated pleomorphic sarcoma 10.1 IDH1 IDH2
43 psychotic disorder 10.0 CNR1 DRD2 HTR1A HTR2A
44 bruxism 10.0 DRD2 HTR2A
45 periosteal osteogenic sarcoma 9.6 FOS IDH1
46 motion sickness 9.5 FOS HTR1A HTR7
47 withdrawal disorder 9.4 CNR1 FOS HTR7
48 pain agnosia 9.4 CNR1 FOS HTR7
49 agnosia 9.4 CNR1 FOS HTR7
50 attention deficit-hyperactivity disorder 9.4 DRD2 FOS HTR1A HTR2A

Graphical network of the top 20 diseases related to Drug-Induced Mental Disorder:



Diseases related to Drug-Induced Mental Disorder

Symptoms & Phenotypes for Drug-Induced Mental Disorder

GenomeRNAi Phenotypes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 DRD2 DUSP26 EPHA5 FOS HTR1A HTR2A

MGI Mouse Phenotypes related to Drug-Induced Mental Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 HTR7 CNR1 DRD2 NDUFS4 PHB2 FOS
2 homeostasis/metabolism MP:0005376 10.02 HTR7 CNR1 IDH1 LHB DRD2 NDUFS4
3 mortality/aging MP:0010768 9.96 HTR7 CNR1 IDH1 DRD2 NDUFS4 PHB2
4 endocrine/exocrine gland MP:0005379 9.91 HTR2A LHB DRD2 PHB2 FOS PINK1
5 nervous system MP:0003631 9.81 HTR7 CNR1 DRD2 NDUFS4 EPHA5 FOS
6 skeleton MP:0005390 9.56 CNR1 IDH1 DRD2 NDUFS4 FOS PINK1
7 taste/olfaction MP:0005394 8.8 CNR1 DRD2 PINK1

Drugs & Therapeutics for Drug-Induced Mental Disorder

Search Clinical Trials , NIH Clinical Center for Drug-Induced Mental Disorder

Genetic Tests for Drug-Induced Mental Disorder

Anatomical Context for Drug-Induced Mental Disorder

Publications for Drug-Induced Mental Disorder

Variations for Drug-Induced Mental Disorder

Expression for Drug-Induced Mental Disorder

Search GEO for disease gene expression data for Drug-Induced Mental Disorder.

Pathways for Drug-Induced Mental Disorder

GO Terms for Drug-Induced Mental Disorder

Cellular components related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.73 CNR1 DRD2 EPHA5 HTR1A HTR2A HTR7
2 mitochondrion GO:0005739 9.7 CNR1 DUSP26 IDH1 IDH2 NDUFS4 PHB2
3 dendrite GO:0030425 9.35 DRD2 EPHA5 HTR1A HTR2A HTR7
4 axon GO:0030424 9.1 CNR1 DRD2 EPHA5 HTR2A PHB2 PINK1

Biological processes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.79 CNR1 FOS HTR2A
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 DRD2 EPHA5 HTR2A PHB2
3 mitochondrion organization GO:0007005 9.69 IDH2 PHB2 PINK1
4 negative regulation of blood pressure GO:0045776 9.62 CNR1 DRD2
5 response to light stimulus GO:0009416 9.61 DRD2 FOS
6 G-protein coupled serotonin receptor signaling pathway GO:0098664 9.61 HTR1A HTR2A
7 behavioral response to cocaine GO:0048148 9.6 DRD2 HTR2A
8 regulation of dopamine secretion GO:0014059 9.59 DRD2 HTR2A
9 temperature homeostasis GO:0001659 9.58 DRD2 HTR2A
10 smooth muscle contraction GO:0006939 9.58 HTR2A HTR7
11 2-oxoglutarate metabolic process GO:0006103 9.57 IDH1 IDH2
12 vasoconstriction GO:0042310 9.56 HTR1A HTR7
13 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.54 DRD2 HTR2A
14 regulation of synaptic transmission, GABAergic GO:0032228 9.52 CNR1 DRD2
15 sleep GO:0030431 9.49 FOS HTR2A
16 regulation of behavior GO:0050795 9.48 HTR1A HTR2A
17 behavior GO:0007610 9.46 HTR1A HTR2A
18 regulation of hormone secretion GO:0046883 9.4 HTR1A HTR2A
19 isocitrate metabolic process GO:0006102 9.37 IDH1 IDH2
20 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.32 HTR1A HTR7
21 serotonin receptor signaling pathway GO:0007210 9.26 HTR1A HTR2A
22 negative regulation of dopamine secretion GO:0033602 9.16 CNR1 DRD2
23 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2
24 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 8.92 CNR1 HTR1A HTR2A HTR7
25 G-protein coupled receptor signaling pathway GO:0007186 10.02 CNR1 DRD2 HTR1A HTR2A HTR7 LHB

Molecular functions related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.83 CNR1 DRD2 HTR1A HTR2A HTR7
2 obsolete signal transducer activity GO:0004871 9.71 CNR1 DRD2 HTR1A HTR2A
3 drug binding GO:0008144 9.54 CNR1 DRD2 HTR2A
4 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR2A HTR7
5 isocitrate dehydrogenase activity GO:0004448 9.32 IDH1 IDH2
6 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.26 IDH1 IDH2
7 G-protein coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR2A HTR7
8 serotonin binding GO:0051378 8.8 HTR1A HTR2A HTR7

Sources for Drug-Induced Mental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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