MCID: DRG004
MIFTS: 27

Drug-Induced Mental Disorder

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Drug-Induced Mental Disorder

MalaCards integrated aliases for Drug-Induced Mental Disorder:

Name: Drug-Induced Mental Disorder 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1203
ICD9CM 35 292.8 292.89
UMLS 72 C0154325

Summaries for Drug-Induced Mental Disorder

MalaCards based summary : Drug-Induced Mental Disorder is related to schizoid personality disorder and hypoactive sexual desire disorder. An important gene associated with Drug-Induced Mental Disorder is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Peptide ligand-binding receptors and Circadian entrainment. Related phenotypes are no effect and Decreased viability after Maraba virus infection

Related Diseases for Drug-Induced Mental Disorder

Diseases related to Drug-Induced Mental Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 schizoid personality disorder 10.6 HTR2A HTR1A
2 hypoactive sexual desire disorder 10.6 HTR2A HTR1A
3 substance-induced psychosis 10.6 HTR2A HTR1A DRD2
4 periodic limb movement disorder 10.5 HTR2A HTR1A DRD2
5 schizophrenia 5 10.5 HTR2A HTR1A
6 delusional disorder 10.4 DRD4 DRD3 DRD2
7 impulse control disorder 10.4 DRD4 DRD3 DRD2
8 schizophreniform disorder 10.4 DRD2 COMT
9 psychosexual disorder 10.4 HTR2A HTR1A
10 alexithymia 10.4 HTR1A DRD2 COMT
11 borderline personality disorder 10.4 HTR2A HTR1A COMT
12 mental depression 10.4 HTR2A HTR1A COMT
13 drug dependence 10.4 DRD3 DRD2 CNR1
14 chronic fatigue syndrome 10.3 HTR2A HTR1A COMT
15 oppositional defiant disorder 10.3 DRD4 DRD2 COMT
16 tic disorder 10.3 HTR2A DRD5 DRD4 DRD2
17 panic disorder 10.3 HTR2A HTR1A COMT
18 bruxism 10.3 HTR2A DRD5 DRD3 DRD2
19 tobacco addiction 10.3 HTR2A DRD2 COMT
20 early-onset schizophrenia 10.3 NDUFS4 HTR2A DRD2 DRD1
21 eating disorder 10.3 DRD2 COMT CNR1
22 generalized anxiety disorder 10.2 HTR2A HTR1A DRD2 COMT
23 bipolar i disorder 10.2 HTR2A HTR1A DRD1 COMT
24 movement disease 10.2 PINK1 DRD3 DRD2
25 tardive dyskinesia 10.2 HTR2A DRD3 DRD2 COMT
26 schizoaffective disorder 10.2 HTR2A DRD3 DRD2 COMT
27 interval angle-closure glaucoma 10.2 IDH2 IDH1
28 conduct disorder 10.1 DRD5 DRD4 DRD2 COMT
29 enchondroma 10.1 IDH2 IDH1
30 anxiety 10.1 HTR2A HTR1A COMT CNR1
31 adult oligodendroglioma 10.1 IDH2 IDH1
32 post-traumatic stress disorder 10.1 HTR2A DRD2 COMT CNR1
33 polysubstance abuse 10.1 DRD3 DRD2 COMT CNR1
34 gilles de la tourette syndrome 10.1 DRD5 DRD4 DRD2 COMT
35 intracranial chondrosarcoma 10.1 IDH2 IDH1
36 prolactin producing pituitary tumor 10.1 NTRK1 DRD2
37 pathological gambling 10.1 HTR2A DRD4 DRD3 DRD2 DRD1
38 cytogenetically normal acute myeloid leukemia 10.0 IDH2 IDH1
39 specific developmental disorder 10.0 DRD5 DRD4 COMT CNR1
40 chondroblastic osteosarcoma 10.0 IDH2 IDH1
41 personality disorder 10.0 HTR2A HTR1A DRD4 DRD2 COMT
42 substance dependence 10.0 DRD5 DRD4 DRD3 DRD2 CNR1
43 substance abuse 9.9 DRD5 DRD4 DRD3 DRD2 COMT
44 intraductal papilloma 9.9 IDH2 IDH1
45 multiple enchondromatosis, maffucci type 9.8 IDH2 IDH1
46 mood disorder 9.8 HTR2A HTR1A DRD4 DRD3 DRD2 COMT
47 spindle cell hemangioma 9.7 IDH2 IDH1
48 undifferentiated pleomorphic sarcoma 9.6 NTRK1 IDH2 IDH1
49 obsessive-compulsive disorder 9.6 HTR2A HTR1A DRD4 DRD3 DRD2 DRD1
50 migraine without aura 9.5 MTHFR HTR1A DRD4 DRD3 DRD2

Graphical network of the top 20 diseases related to Drug-Induced Mental Disorder:



Diseases related to Drug-Induced Mental Disorder

Symptoms & Phenotypes for Drug-Induced Mental Disorder

GenomeRNAi Phenotypes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ADAMTS2 CNR1 COMT DRD1 DRD2 DRD3
2 Decreased viability after Maraba virus infection GR00252-A-1 9.83 CNR1 DRD1 DRD3 EPHA5 HTR2A PINK1
3 Decreased viability after Maraba virus infection GR00252-A-2 9.83 CNR1 DRD1 DRD3 EPHA5 PINK1
4 Decreased viability after Maraba virus infection GR00252-A-3 9.83 DRD1 EPHA5 HTR2A PINK1

MGI Mouse Phenotypes related to Drug-Induced Mental Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.27 CNR1 COMT DRD1 DRD2 DRD3 DRD4
2 homeostasis/metabolism MP:0005376 10.18 CNR1 COMT DRD1 DRD2 DRD3 DRD4
3 growth/size/body region MP:0005378 10.14 ADAMTS2 CNR1 DRD1 DRD2 DRD3 IDH1
4 cardiovascular system MP:0005385 10.09 COMT DRD1 DRD2 DRD3 DRD5 HTR1A
5 mortality/aging MP:0010768 10.03 CNR1 DRD1 DRD2 DRD3 DRD5 HTR1A
6 nervous system MP:0003631 10 CNR1 COMT DRD1 DRD2 DRD3 DRD4
7 integument MP:0010771 9.92 ADAMTS2 CNR1 DRD1 DRD2 MTHFR NDUFS4
8 respiratory system MP:0005388 9.5 ADAMTS2 COMT DRD1 DRD2 IDH1 NDUFS4
9 skeleton MP:0005390 9.28 ADAMTS2 CNR1 DRD2 HTR2A IDH1 MTHFR

Drugs & Therapeutics for Drug-Induced Mental Disorder

Search Clinical Trials , NIH Clinical Center for Drug-Induced Mental Disorder

Genetic Tests for Drug-Induced Mental Disorder

Anatomical Context for Drug-Induced Mental Disorder

Publications for Drug-Induced Mental Disorder

Articles related to Drug-Induced Mental Disorder:

# Title Authors PMID Year
1
[Disorder of train of thought in the elderly]. 38
24261209 2013

Variations for Drug-Induced Mental Disorder

Expression for Drug-Induced Mental Disorder

Search GEO for disease gene expression data for Drug-Induced Mental Disorder.

Pathways for Drug-Induced Mental Disorder

Pathways related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 LHB HTR2A HTR1A DRD5 DRD4 DRD3
2
Show member pathways
12.82 DRD5 DRD4 DRD3 DRD2 DRD1 COMT
3
Show member pathways
12.61 DRD5 DRD4 DRD3 DRD2 DRD1
4 12.35 MTHFR IDH2 IDH1 CNR1
5 12.34 PINK1 NTRK1 HTR1A COMT CNR1
6 12.13 HTR1A DRD5 DRD2 DRD1
7 12.01 DRD5 DRD4 DRD3 DRD2 DRD1
8
Show member pathways
11.98 DRD5 DRD4 DRD2 DRD1
10
Show member pathways
11.73 DRD4 DRD3 DRD2
11 11.64 HTR2A DRD2 DRD1
12 11.63 HTR2A DRD4 DRD3 CNR1
13 11.26 NTRK1 DRD2 DRD1
14
Show member pathways
11.21 HTR2A HTR1A DRD5 DRD4 DRD3 DRD2
15
Show member pathways
10.65 IDH2 IDH1
16 10.6 DRD5 DRD3 DRD2 DRD1

GO Terms for Drug-Induced Mental Disorder

Cellular components related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamatergic synapse GO:0098978 9.8 HTR2A DRD4 DRD3 DRD2 DRD1 CNR1
2 dendrite GO:0030425 9.7 NTRK1 HTR2A HTR1A EPHA5 DRD4 DRD2
3 GABA-ergic synapse GO:0098982 9.67 DRD3 DRD2 DRD1 CNR1
4 integral component of plasma membrane GO:0005887 9.65 NTRK1 HTR2A HTR1A EPHA5 DRD5 DRD4
5 ciliary membrane GO:0060170 9.63 DRD5 DRD2 DRD1
6 integral component of postsynaptic membrane GO:0099055 9.61 HTR2A DRD2 DRD1
7 non-motile cilium GO:0097730 9.58 DRD5 DRD2 DRD1
8 integral component of presynaptic membrane GO:0099056 9.56 HTR2A DRD2 DRD1 CNR1
9 dopaminergic synapse GO:0098691 9.48 DRD3 DRD2
10 axon GO:0030424 9.17 PINK1 NTRK1 HTR2A EPHA5 DRD2 COMT

Biological processes related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.91 DRD3 DRD2 CNR1
2 locomotory behavior GO:0007626 9.9 DRD3 DRD2 DRD1
3 cellular calcium ion homeostasis GO:0006874 9.9 HTR2A DRD5 DRD4 DRD3
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 NTRK1 HTR2A DRD2
5 memory GO:0007613 9.89 HTR2A DRD1 CNR1
6 learning GO:0007612 9.87 DRD3 DRD1 COMT
7 learning or memory GO:0007611 9.86 NTRK1 DRD3 CNR1
8 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.86 DRD3 DRD2 CNR1
9 sensory perception of pain GO:0019233 9.85 NTRK1 HTR2A CNR1
10 regulation of synaptic vesicle exocytosis GO:2000300 9.85 HTR2A DRD2 DRD1
11 visual learning GO:0008542 9.85 DRD3 DRD2 DRD1
12 response to nicotine GO:0035094 9.83 NTRK1 DRD2 CNR1
13 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.81 HTR2A HTR1A DRD4
14 response to morphine GO:0043278 9.8 DRD3 DRD2 CNR1
15 behavioral fear response GO:0001662 9.8 HTR1A DRD4 DRD1
16 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.8 HTR2A HTR1A DRD4 DRD1 CNR1
17 associative learning GO:0008306 9.79 DRD5 DRD2 DRD1
18 negative regulation of blood pressure GO:0045776 9.78 DRD5 DRD3 DRD2 CNR1
19 arachidonic acid secretion GO:0050482 9.77 DRD4 DRD3 DRD2
20 temperature homeostasis GO:0001659 9.76 HTR2A DRD2 DRD1
21 negative regulation of protein secretion GO:0050709 9.75 DRD4 DRD3 DRD2
22 prepulse inhibition GO:0060134 9.74 DRD3 DRD2 DRD1
23 long-term synaptic depression GO:0060292 9.73 DRD5 DRD1
24 striatum development GO:0021756 9.73 DRD2 DRD1
25 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.73 NTRK1 HTR2A
26 regulation of synaptic transmission, GABAergic GO:0032228 9.73 DRD2 CNR1
27 positive regulation of renal sodium excretion GO:0035815 9.73 DRD3 DRD2
28 grooming behavior GO:0007625 9.73 DRD2 DRD1
29 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.72 DRD4 DRD3
30 G protein-coupled receptor internalization GO:0002031 9.72 DRD3 DRD2
31 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.72 NTRK1 HTR2A
32 regulation of dopamine metabolic process GO:0042053 9.72 HTR1A DRD4 DRD1
33 peristalsis GO:0030432 9.71 DRD2 DRD1
34 serotonin receptor signaling pathway GO:0007210 9.71 HTR2A HTR1A
35 negative regulation of voltage-gated calcium channel activity GO:1901386 9.71 DRD4 DRD2
36 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.71 DRD4 DRD3 DRD2
37 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.7 HTR2A DRD2
38 NADP metabolic process GO:0006739 9.7 IDH2 IDH1
39 behavioral response to ethanol GO:0048149 9.7 DRD4 DRD2
40 behavior GO:0007610 9.7 HTR2A HTR1A
41 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.7 DRD5 DRD3 DRD1
42 mating behavior GO:0007617 9.69 DRD5 DRD1
43 cellular response to catecholamine stimulus GO:0071870 9.69 DRD5 DRD1
44 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.69 DRD5 DRD2 DRD1
45 cerebral cortex GABAergic interneuron migration GO:0021853 9.68 DRD2 DRD1
46 isocitrate metabolic process GO:0006102 9.67 IDH2 IDH1
47 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.67 DRD3 DRD2 DRD1
48 synaptic transmission, dopaminergic GO:0001963 9.67 DRD5 DRD3 DRD2 DRD1
49 negative regulation of dopamine receptor signaling pathway GO:0060160 9.66 DRD3 DRD2
50 regulation of locomotion involved in locomotory behavior GO:0090325 9.65 DRD3 DRD2

Molecular functions related to Drug-Induced Mental Disorder according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.92 HTR2A HTR1A DRD5 DRD4 DRD3 DRD2
2 magnesium ion binding GO:0000287 9.83 PINK1 IDH2 IDH1 COMT
3 neurotransmitter receptor activity GO:0030594 9.67 HTR2A HTR1A DRD4
4 G protein-coupled serotonin receptor activity GO:0004993 9.65 HTR2A HTR1A DRD4
5 adrenergic receptor activity GO:0004935 9.55 DRD3 DRD2
6 drug binding GO:0008144 9.55 HTR2A DRD4 DRD3 DRD2 CNR1
7 serotonin binding GO:0051378 9.54 HTR2A HTR1A
8 G-protein alpha-subunit binding GO:0001965 9.54 HTR2A DRD5 DRD1
9 GPI-linked ephrin receptor activity GO:0005004 9.51 NTRK1 EPHA5
10 isocitrate dehydrogenase activity GO:0004448 9.46 IDH2 IDH1
11 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.43 IDH2 IDH1
12 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.43 DRD4 DRD3 DRD2
13 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.4 DRD5 DRD1
14 dopamine binding GO:0035240 9.35 DRD5 DRD4 DRD3 DRD2 DRD1
15 dopamine neurotransmitter receptor activity GO:0004952 9.02 DRD5 DRD4 DRD3 DRD2 DRD1

Sources for Drug-Induced Mental Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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