MCID: DRG022
MIFTS: 12

Drug Metabolism, Altered, Cyp2c8-Related

Categories: Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Drug Metabolism, Altered, Cyp2c8-Related

MalaCards integrated aliases for Drug Metabolism, Altered, Cyp2c8-Related:

Name: Drug Metabolism, Altered, Cyp2c8-Related 57 29 6
Enzalutamide Toxicity 58

Classifications:



External Ids:

OMIM® 57 618018
Orphanet 58 ORPHA529828

Summaries for Drug Metabolism, Altered, Cyp2c8-Related

OMIM® : 57 CYP2C8 is involved in the metabolism of a multitude of chemically diverse medications, including nonsteroidal antiinflammatory drugs, thiazolidinediones, and chemotherapeutic agents (summary by Zhou et al., 2017). Backman et al. (2016) reviewed the role of CYP2C8 in clinically relevant drug interactions. (618018) (Updated 20-May-2021)

MalaCards based summary : Drug Metabolism, Altered, Cyp2c8-Related, is also known as enzalutamide toxicity. An important gene associated with Drug Metabolism, Altered, Cyp2c8-Related is CYP2C8 (Cytochrome P450 Family 2 Subfamily C Member 8). Affiliated tissues include prostate.

Related Diseases for Drug Metabolism, Altered, Cyp2c8-Related

Diseases in the Drug Metabolism, Altered, Ces1-Related family:

Drug Metabolism, Altered, Cyp2c8-Related

Symptoms & Phenotypes for Drug Metabolism, Altered, Cyp2c8-Related

Clinical features from OMIM®:

618018 (Updated 20-May-2021)

Drugs & Therapeutics for Drug Metabolism, Altered, Cyp2c8-Related

Search Clinical Trials , NIH Clinical Center for Drug Metabolism, Altered, Cyp2c8-Related

Genetic Tests for Drug Metabolism, Altered, Cyp2c8-Related

Genetic tests related to Drug Metabolism, Altered, Cyp2c8-Related:

# Genetic test Affiliating Genes
1 Drug Metabolism, Altered, Cyp2c8-Related 29 CYP2C8

Anatomical Context for Drug Metabolism, Altered, Cyp2c8-Related

MalaCards organs/tissues related to Drug Metabolism, Altered, Cyp2c8-Related:

40
Prostate

Publications for Drug Metabolism, Altered, Cyp2c8-Related

Articles related to Drug Metabolism, Altered, Cyp2c8-Related:

# Title Authors PMID Year
1
A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin. 57 6
15365880 2004
2
Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects. 57
28378927 2017
3
Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. 57
26721703 2016
4
Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. 61
31596947 2019
5
Practical guide to the use of enzalutamide. 61
24775726 2014

Variations for Drug Metabolism, Altered, Cyp2c8-Related

ClinVar genetic disease variations for Drug Metabolism, Altered, Cyp2c8-Related:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CYP2C8 CYP2C8*5 Deletion Pathogenic 8411 rs72558196 GRCh37: 10:96826971-96826971
GRCh38: 10:95067214-95067214

Expression for Drug Metabolism, Altered, Cyp2c8-Related

Search GEO for disease gene expression data for Drug Metabolism, Altered, Cyp2c8-Related.

Pathways for Drug Metabolism, Altered, Cyp2c8-Related

GO Terms for Drug Metabolism, Altered, Cyp2c8-Related

Sources for Drug Metabolism, Altered, Cyp2c8-Related

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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