MCID: DRG001
MIFTS: 34

Drug Psychosis

Categories: Mental diseases

Aliases & Classifications for Drug Psychosis

MalaCards integrated aliases for Drug Psychosis:

Name: Drug Psychosis 12 15
Drug-Induced Psychotic Disorder 12
Psychoses, Substance-Induced 44
Drug-Induced Psychosis 12
Psychoses, Drug 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1742
ICD9CM 35 292.1
MeSH 44 D011605
UMLS 73 C0033937

Summaries for Drug Psychosis

MalaCards based summary : Drug Psychosis, also known as drug-induced psychotic disorder, is related to schizophrenia and schizoid personality disorder. An important gene associated with Drug Psychosis is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Serotonergic synapse and GPCRs, Other. The drugs Tranquilizing Agents and Central Nervous System Depressants have been mentioned in the context of this disorder. Affiliated tissues include cerebellum and myeloid, and related phenotypes are shRNA abundance <= 50% and behavior/neurological

Related Diseases for Drug Psychosis

Diseases related to Drug Psychosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 29.2 CNR1 DRD2 HTR1A HTR2A HTR7
2 schizoid personality disorder 10.3 HTR1A HTR2A
3 hypoactive sexual desire disorder 10.3 HTR1A HTR2A
4 tic disorder 10.2 DRD2 HTR2A
5 tendinitis 10.2 LHB PHB2
6 bursitis 10.2 NDUFS4 PHB2
7 tardive dyskinesia 10.2 DRD2 HTR2A
8 anxiety 10.2 CNR1 HTR1A HTR2A
9 polysubstance abuse 10.2 CNR1 DRD2
10 alcoholic psychosis 10.2 DRD2 HTR2A
11 social phobia 10.1 DRD2 HTR1A
12 atypical depressive disorder 10.1 HTR2A HTR7
13 rumination disorder 10.1 HTR1A HTR7
14 substance-induced psychosis 10.1 DRD2 HTR1A HTR2A
15 interval angle-closure glaucoma 10.1 IDH1 IDH2
16 periodic limb movement disorder 10.1 DRD2 HTR1A HTR2A
17 pathological gambling 10.1 DRD2 HTR2A
18 adult oligodendroglioma 10.1 IDH1 IDH2
19 enchondroma 10.1 IDH1 IDH2
20 personality disorder 10.1 DRD2 HTR1A HTR2A
21 intracranial chondrosarcoma 10.1 IDH1 IDH2
22 generalized anxiety disorder 10.1 DRD2 HTR1A HTR2A
23 cytogenetically normal acute myeloid leukemia 10.1 IDH1 IDH2
24 coronary artery vasospasm 10.1 HTR2A HTR7
25 chondroblastic osteosarcoma 10.1 IDH1 IDH2
26 mood disorder 10.1 DRD2 HTR1A HTR2A
27 multiple enchondromatosis, maffucci type 10.1 IDH1 IDH2
28 psychotic disorder 10.1 DRD2 HTR1A HTR2A
29 intraductal papilloma 10.1 IDH1 IDH2
30 alexithymia 10.1 DRD2 HTR1A
31 pilocytic astrocytoma of cerebellum 10.1 IDH1 IDH2
32 early-onset schizophrenia 10.1 DRD2 HTR2A NDUFS4
33 obsessive-compulsive disorder 10.1 DRD2 HTR1A HTR2A
34 spindle cell hemangioma 10.1 IDH1 IDH2
35 central nervous system disease 10.1 CNR1 HTR2A PINK1
36 post-traumatic stress disorder 10.1 CNR1 DRD2 HTR2A
37 dysthymic disorder 10.1 HTR2A HTR7
38 alcohol abuse 10.1 CNR1 DRD2 HTR2A
39 periosteal chondrosarcoma 10.1 IDH1 IDH2
40 neuroleptic malignant syndrome 10.1 DRD2 HTR1A
41 glioma susceptibility 1 10.1 IDH1 IDH2
42 kleptomania 10.1 HTR1A HTR7
43 adult astrocytic tumour 10.1 IDH1 IDH2
44 psychosexual disorder 10.1 HTR1A HTR2A HTR7
45 mental depression 10.0 HTR1A HTR2A HTR7
46 fibrillary astrocytoma 10.0 IDH1 IDH2
47 endogenous depression 10.0 HTR1A HTR2A HTR7
48 diffuse infiltrative lymphocytosis syndrome 10.0 IDH1 IDH2
49 amnestic disorder 10.0 CNR1 HTR1A HTR7
50 undifferentiated pleomorphic sarcoma 10.0 IDH1 IDH2

Graphical network of the top 20 diseases related to Drug Psychosis:



Diseases related to Drug Psychosis

Symptoms & Phenotypes for Drug Psychosis

GenomeRNAi Phenotypes related to Drug Psychosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.28 DRD2 DUSP26 EPHA5 FOS HTR1A HTR2A

MGI Mouse Phenotypes related to Drug Psychosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 CNR1 DRD2 FOS HTR1A HTR2A HTR7
2 homeostasis/metabolism MP:0005376 9.85 CNR1 DRD2 DUSP26 FOS HTR1A HTR7
3 skeleton MP:0005390 9.5 CNR1 DRD2 FOS HTR2A IDH1 NDUFS4
4 taste/olfaction MP:0005394 8.8 CNR1 DRD2 PINK1

Drugs & Therapeutics for Drug Psychosis

Drugs for Drug Psychosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tranquilizing Agents Phase 4,Not Applicable
2 Central Nervous System Depressants Phase 4,Not Applicable
3 Antipsychotic Agents Phase 4,Not Applicable
4 Quetiapine Fumarate Phase 4 111974-72-2
5 Psychotropic Drugs Phase 4,Not Applicable
6
Clozapine Approved Not Applicable 5786-21-0 2818
7 Serotonin Antagonists Not Applicable
8 GABA Agents Not Applicable
9 Serotonin Agents Not Applicable
10 Neurotransmitter Agents Not Applicable
11
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry Unknown status NCT00986167 Phase 4 Quetiapine XR
2 Study of Clozapine for the Treatment of Psychosis in Patients With Idiopathic Parkinson's Disease Completed NCT00004826 Not Applicable clozapine

Search NIH Clinical Center for Drug Psychosis

Cochrane evidence based reviews: psychoses, substance-induced

Genetic Tests for Drug Psychosis

Anatomical Context for Drug Psychosis

MalaCards organs/tissues related to Drug Psychosis:

41
Cerebellum, Myeloid

Publications for Drug Psychosis

Articles related to Drug Psychosis:

# Title Authors Year
1
Analysis of overall gene expression induced by amphetamine and phencyclidine: novel targets for the treatment of drug psychosis and schizophrenia. ( 11812256 )
2002

Variations for Drug Psychosis

Expression for Drug Psychosis

Search GEO for disease gene expression data for Drug Psychosis.

Pathways for Drug Psychosis

GO Terms for Drug Psychosis

Cellular components related to Drug Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.8 CNR1 IDH1 IDH2 NDUFS4 PHB2 PINK1
2 integral component of plasma membrane GO:0005887 9.73 CNR1 DRD2 EPHA5 HTR1A HTR2A HTR7
3 mitochondrial outer membrane GO:0005741 9.54 CNR1 PHB2 PINK1
4 dendrite GO:0030425 9.35 DRD2 EPHA5 HTR1A HTR2A HTR7
5 integral component of presynaptic membrane GO:0099056 9.33 CNR1 DRD2 HTR2A
6 axon GO:0030424 9.02 CNR1 DRD2 EPHA5 HTR2A PINK1

Biological processes related to Drug Psychosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.99 CNR1 DRD2 HTR1A HTR2A HTR7 LHB
2 aging GO:0007568 9.76 CNR1 FOS HTR2A
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 DRD2 EPHA5 HTR2A PHB2
4 tricarboxylic acid cycle GO:0006099 9.61 IDH1 IDH2
5 response to morphine GO:0043278 9.61 CNR1 DRD2
6 cAMP-mediated signaling GO:0019933 9.6 EPHA5 NDUFS4
7 negative regulation of blood pressure GO:0045776 9.59 CNR1 DRD2
8 response to light stimulus GO:0009416 9.58 DRD2 FOS
9 temperature homeostasis GO:0001659 9.57 DRD2 HTR2A
10 2-oxoglutarate metabolic process GO:0006103 9.56 IDH1 IDH2
11 behavioral response to cocaine GO:0048148 9.55 DRD2 HTR2A
12 vasoconstriction GO:0042310 9.54 HTR1A HTR7
13 regulation of synaptic transmission, GABAergic GO:0032228 9.52 CNR1 DRD2
14 sleep GO:0030431 9.49 FOS HTR2A
15 behavior GO:0007610 9.48 HTR1A HTR2A
16 NADP metabolic process GO:0006739 9.46 IDH1 IDH2
17 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.43 DRD2 HTR2A
18 serotonin receptor signaling pathway GO:0007210 9.4 HTR1A HTR2A
19 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.33 HTR1A HTR2A HTR7
20 isocitrate metabolic process GO:0006102 9.32 IDH1 IDH2
21 negative regulation of dopamine secretion GO:0033602 9.26 CNR1 DRD2
22 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2
23 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 8.92 CNR1 HTR1A HTR2A HTR7

Molecular functions related to Drug Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.8 CNR1 DRD2 HTR1A HTR2A HTR7
2 drug binding GO:0008144 9.5 CNR1 DRD2 HTR2A
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.43 IDH1 IDH2
4 neurotransmitter receptor activity GO:0030594 9.43 HTR1A HTR2A HTR7
5 serotonin binding GO:0051378 9.37 HTR1A HTR2A
6 G protein-coupled serotonin receptor activity GO:0004993 9.33 HTR1A HTR2A HTR7
7 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
8 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Drug Psychosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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