MCID: DRG001
MIFTS: 33

Drug Psychosis

Categories: Mental diseases

Aliases & Classifications for Drug Psychosis

MalaCards integrated aliases for Drug Psychosis:

Name: Drug Psychosis 12 15
Drug-Induced Psychotic Disorder 12
Psychoses, Substance-Induced 44
Drug-Induced Psychosis 12
Psychoses, Drug 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1742
ICD9CM 35 292.1
MeSH 44 D011605
UMLS 73 C0033937

Summaries for Drug Psychosis

MalaCards based summary : Drug Psychosis, also known as drug-induced psychotic disorder, is related to schizophrenia and schizoid personality disorder. An important gene associated with Drug Psychosis is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Serotonergic synapse and GPCRs, Other. The drugs Quetiapine Fumarate and Central Nervous System Depressants have been mentioned in the context of this disorder. Related phenotypes are shRNA abundance <= 50% and behavior/neurological

Related Diseases for Drug Psychosis

Diseases related to Drug Psychosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 27.9 CNR1 DRD2 HTR1A HTR2A HTR7
2 schizoid personality disorder 10.9 HTR1A HTR2A
3 hypoactive sexual desire disorder 10.9 HTR1A HTR2A
4 substance-induced psychosis 10.9 HTR1A HTR2A
5 tendinitis 10.5 LHB PHB2
6 tardive dyskinesia 10.5 DRD2 HTR2A
7 alcoholic psychosis 10.5 DRD2 HTR2A
8 bursitis 10.5 NDUFS4 PHB2
9 polysubstance abuse 10.5 CNR1 DRD2
10 anxiety 10.5 CNR1 HTR1A HTR2A
11 social phobia 10.5 DRD2 HTR1A
12 rumination disorder 10.4 HTR1A HTR7
13 periodic limb movement disorder 10.4 DRD2 HTR1A HTR2A
14 interval angle-closure glaucoma 10.4 IDH1 IDH2
15 generalized anxiety disorder 10.4 DRD2 HTR1A HTR2A
16 personality disorder 10.3 DRD2 HTR1A HTR2A
17 coronary artery vasospasm 10.3 HTR2A HTR7
18 adult oligodendroglioma 10.3 IDH1 IDH2
19 enchondroma 10.3 IDH1 IDH2
20 intracranial chondrosarcoma 10.3 IDH1 IDH2
21 cytogenetically normal acute myeloid leukemia 10.3 IDH1 IDH2
22 mood disorder 10.3 DRD2 HTR1A HTR2A
23 chondroblastic osteosarcoma 10.3 IDH1 IDH2
24 obsessive-compulsive disorder 10.3 DRD2 HTR1A HTR2A
25 pathological gambling 10.3 DRD2 HTR2A
26 intraductal papilloma 10.3 IDH1 IDH2
27 multiple enchondromatosis, maffucci type 10.3 IDH1 IDH2
28 post-traumatic stress disorder 10.3 CNR1 DRD2 HTR2A
29 alexithymia 10.3 DRD2 HTR1A
30 early-onset schizophrenia 10.3 DRD2 HTR2A NDUFS4
31 pilocytic astrocytoma of cerebellum 10.3 IDH1 IDH2
32 spindle cell hemangioma 10.2 IDH1 IDH2
33 dysthymic disorder 10.2 HTR2A HTR7
34 glioma susceptibility 1 10.2 IDH1 IDH2
35 neuroleptic malignant syndrome 10.2 DRD2 HTR1A
36 periosteal chondrosarcoma 10.2 IDH1 IDH2
37 psychosexual disorder 10.2 HTR1A HTR2A HTR7
38 mental depression 10.2 HTR1A HTR2A HTR7
39 adult astrocytic tumour 10.2 IDH1 IDH2
40 kleptomania 10.1 HTR1A HTR7
41 fibrillary astrocytoma 10.1 IDH1 IDH2
42 tic disorder 10.1 DRD2 HTR2A
43 undifferentiated pleomorphic sarcoma 10.1 IDH1 IDH2
44 psychotic disorder 10.0 CNR1 DRD2 HTR1A HTR2A
45 bruxism 10.0 DRD2 HTR2A
46 capgras syndrome 9.7
47 koro 9.7
48 periosteal osteogenic sarcoma 9.6 FOS IDH1
49 motion sickness 9.5 FOS HTR1A HTR7
50 withdrawal disorder 9.4 CNR1 FOS HTR7

Graphical network of the top 20 diseases related to Drug Psychosis:



Diseases related to Drug Psychosis

Symptoms & Phenotypes for Drug Psychosis

GenomeRNAi Phenotypes related to Drug Psychosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 DRD2 DUSP26 EPHA5 FOS HTR1A HTR2A

MGI Mouse Phenotypes related to Drug Psychosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 NDUFS4 PHB2 FOS PINK1 HTR1A HTR2A
2 homeostasis/metabolism MP:0005376 10.02 NDUFS4 DUSP26 FOS PINK1 HTR1A HTR7
3 mortality/aging MP:0010768 9.96 DRD2 NDUFS4 PHB2 FOS PINK1 HTR1A
4 endocrine/exocrine gland MP:0005379 9.91 DRD2 PHB2 FOS PINK1 TCOF1 HTR2A
5 nervous system MP:0003631 9.81 NDUFS4 EPHA5 FOS PINK1 HTR1A TCOF1
6 skeleton MP:0005390 9.56 FOS PINK1 TCOF1 HTR2A CNR1 IDH1
7 taste/olfaction MP:0005394 8.8 DRD2 PINK1 CNR1

Drugs & Therapeutics for Drug Psychosis

Drugs for Drug Psychosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Quetiapine Fumarate Phase 4 111974-72-2
2 Central Nervous System Depressants Phase 4,Not Applicable
3 Tranquilizing Agents Phase 4,Not Applicable
4 Antipsychotic Agents Phase 4,Not Applicable
5 Psychotropic Drugs Phase 4,Not Applicable
6
Clozapine Approved Not Applicable 5786-21-0 2818
7 GABA Agents Not Applicable
8 Serotonin Agents Not Applicable
9 Serotonin Antagonists Not Applicable
10 Neurotransmitter Agents Not Applicable
11
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry Unknown status NCT00986167 Phase 4 Quetiapine XR
2 Study of Clozapine for the Treatment of Psychosis in Patients With Idiopathic Parkinson's Disease Completed NCT00004826 Not Applicable clozapine

Search NIH Clinical Center for Drug Psychosis

Cochrane evidence based reviews: psychoses, substance-induced

Genetic Tests for Drug Psychosis

Anatomical Context for Drug Psychosis

Publications for Drug Psychosis

Articles related to Drug Psychosis:

# Title Authors Year
1
Analysis of overall gene expression induced by amphetamine and phencyclidine: novel targets for the treatment of drug psychosis and schizophrenia. ( 11812256 )
2002

Variations for Drug Psychosis

Expression for Drug Psychosis

Search GEO for disease gene expression data for Drug Psychosis.

Pathways for Drug Psychosis

GO Terms for Drug Psychosis

Cellular components related to Drug Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.73 CNR1 DRD2 EPHA5 HTR1A HTR2A HTR7
2 mitochondrion GO:0005739 9.7 CNR1 DUSP26 IDH1 IDH2 NDUFS4 PHB2
3 dendrite GO:0030425 9.35 DRD2 EPHA5 HTR1A HTR2A HTR7
4 axon GO:0030424 9.1 CNR1 DRD2 EPHA5 HTR2A PHB2 PINK1

Biological processes related to Drug Psychosis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.79 CNR1 FOS HTR2A
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 DRD2 EPHA5 HTR2A PHB2
3 mitochondrion organization GO:0007005 9.69 IDH2 PHB2 PINK1
4 negative regulation of blood pressure GO:0045776 9.62 CNR1 DRD2
5 response to light stimulus GO:0009416 9.61 DRD2 FOS
6 G-protein coupled serotonin receptor signaling pathway GO:0098664 9.61 HTR1A HTR2A
7 behavioral response to cocaine GO:0048148 9.6 DRD2 HTR2A
8 regulation of dopamine secretion GO:0014059 9.59 DRD2 HTR2A
9 temperature homeostasis GO:0001659 9.58 DRD2 HTR2A
10 smooth muscle contraction GO:0006939 9.58 HTR2A HTR7
11 2-oxoglutarate metabolic process GO:0006103 9.57 IDH1 IDH2
12 vasoconstriction GO:0042310 9.56 HTR1A HTR7
13 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.54 DRD2 HTR2A
14 regulation of synaptic transmission, GABAergic GO:0032228 9.52 CNR1 DRD2
15 sleep GO:0030431 9.49 FOS HTR2A
16 regulation of behavior GO:0050795 9.48 HTR1A HTR2A
17 behavior GO:0007610 9.46 HTR1A HTR2A
18 regulation of hormone secretion GO:0046883 9.4 HTR1A HTR2A
19 isocitrate metabolic process GO:0006102 9.37 IDH1 IDH2
20 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.32 HTR1A HTR7
21 serotonin receptor signaling pathway GO:0007210 9.26 HTR1A HTR2A
22 negative regulation of dopamine secretion GO:0033602 9.16 CNR1 DRD2
23 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2
24 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 8.92 CNR1 HTR1A HTR2A HTR7
25 G-protein coupled receptor signaling pathway GO:0007186 10.02 CNR1 DRD2 HTR1A HTR2A HTR7 LHB

Molecular functions related to Drug Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.83 CNR1 DRD2 HTR1A HTR2A HTR7
2 obsolete signal transducer activity GO:0004871 9.71 CNR1 DRD2 HTR1A HTR2A
3 drug binding GO:0008144 9.54 CNR1 DRD2 HTR2A
4 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR2A HTR7
5 isocitrate dehydrogenase activity GO:0004448 9.32 IDH1 IDH2
6 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.26 IDH1 IDH2
7 G-protein coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR2A HTR7
8 serotonin binding GO:0051378 8.8 HTR1A HTR2A HTR7

Sources for Drug Psychosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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