MCID: DRG001
MIFTS: 35

Drug Psychosis

Categories: Mental diseases

Aliases & Classifications for Drug Psychosis

MalaCards integrated aliases for Drug Psychosis:

Name: Drug Psychosis 12 15 17
Drug-Induced Psychotic Disorder 12
Psychoses, Substance-Induced 45
Drug-Induced Psychosis 12
Psychoses, Drug 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1742
ICD9CM 36 292.1
MeSH 45 D011605
UMLS 74 C0033937

Summaries for Drug Psychosis

MalaCards based summary : Drug Psychosis, also known as drug-induced psychotic disorder, is related to personality disorder and schizophrenia. An important gene associated with Drug Psychosis is HTR1A (5-Hydroxytryptamine Receptor 1A), and among its related pathways/superpathways are Peptide ligand-binding receptors and G-Beta Gamma Signaling. The drugs Tranquilizing Agents and Antipsychotic Agents have been mentioned in the context of this disorder. Related phenotypes are Decreased viability after Maraba virus infection and Decreased viability after Maraba virus infection

Related Diseases for Drug Psychosis

Diseases related to Drug Psychosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 personality disorder 30.0 DRD2 DRD4 HTR1A HTR2A
2 schizophrenia 28.9 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
3 schizoid personality disorder 10.4 HTR1A HTR2A
4 hypoactive sexual desire disorder 10.4 HTR1A HTR2A
5 schizophrenia 5 10.4 HTR1A HTR2A
6 psychosexual disorder 10.4 HTR1A HTR2A
7 substance-induced psychosis 10.3 DRD2 HTR1A HTR2A
8 alcoholic psychosis 10.3 DRD2 HTR2A
9 periodic limb movement disorder 10.3 DRD2 HTR1A HTR2A
10 bipolar i disorder 10.3 DRD1 HTR1A HTR2A
11 generalized anxiety disorder 10.3 DRD2 HTR1A HTR2A
12 tardive dyskinesia 10.3 DRD2 DRD3 HTR2A
13 schizoaffective disorder 10.3 DRD2 DRD3 HTR2A
14 delusional disorder 10.3 DRD2 DRD3 DRD4
15 impulse control disorder 10.3 DRD2 DRD3 DRD4
16 conduct disorder 10.3 DRD2 DRD4 DRD5
17 social phobia 10.2 DRD2 HTR1A
18 polysubstance abuse 10.2 CNR1 DRD2 DRD3
19 anxiety 10.2 CNR1 HTR1A HTR2A
20 post-traumatic stress disorder 10.2 CNR1 DRD2 HTR2A
21 gilles de la tourette syndrome 10.2 DRD2 DRD4 DRD5
22 drug dependence 10.2 CNR1 DRD2 DRD3
23 specific developmental disorder 10.2 CNR1 DRD4 DRD5
24 bruxism 10.2 DRD2 DRD3 DRD5 HTR2A
25 bipolar disorder 10.2 DRD2 DRD3 HTR1A HTR2A
26 movement disease 10.2 DRD2 DRD3 PINK1
27 migraine without aura 10.2 DRD2 DRD3 DRD4 HTR1A
28 tic disorder 10.2 DRD2 DRD4 DRD5 HTR2A
29 bursitis 10.1 NDUFS4 PHB2
30 tendinitis 10.1 LHB PHB2
31 early-onset schizophrenia 10.1 DRD1 DRD2 HTR2A NDUFS4
32 substance abuse 10.1 DRD2 DRD3 DRD4 DRD5
33 interval angle-closure glaucoma 10.1 IDH1 IDH2
34 adult oligodendroglioma 10.0 IDH1 IDH2
35 enchondroma 10.0 IDH1 IDH2
36 intracranial chondrosarcoma 10.0 IDH1 IDH2
37 pathological gambling 10.0 DRD1 DRD2 DRD3 DRD4 HTR2A
38 mood disorder 10.0 DRD2 DRD3 DRD4 HTR1A HTR2A
39 cytogenetically normal acute myeloid leukemia 10.0 IDH1 IDH2
40 major depressive disorder 10.0 DRD2 DRD3 DRD4 HTR1A HTR2A
41 chondroblastic osteosarcoma 10.0 IDH1 IDH2
42 multiple enchondromatosis, maffucci type 10.0 IDH1 IDH2
43 intraductal papilloma 10.0 IDH1 IDH2
44 pilocytic astrocytoma of cerebellum 10.0 IDH1 IDH2
45 central nervous system disease 10.0 CNR1 HTR2A PINK1
46 spindle cell hemangioma 10.0 IDH1 IDH2
47 periosteal chondrosarcoma 10.0 IDH1 IDH2
48 substance dependence 9.9 CNR1 DRD2 DRD3 DRD4 DRD5
49 glioma susceptibility 1 9.9 IDH1 IDH2
50 psychotic disorder 9.9 DRD1 DRD2 DRD3 DRD4 HTR1A HTR2A

Graphical network of the top 20 diseases related to Drug Psychosis:



Diseases related to Drug Psychosis

Symptoms & Phenotypes for Drug Psychosis

GenomeRNAi Phenotypes related to Drug Psychosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability after Maraba virus infection GR00252-A-1 9.83 CNR1 DRD1 DRD3 EPHA5 HTR2A PINK1
2 Decreased viability after Maraba virus infection GR00252-A-2 9.83 CNR1 DRD1 DRD3 EPHA5 PINK1
3 Decreased viability after Maraba virus infection GR00252-A-3 9.83 DRD1 EPHA5 HTR2A PINK1
4 shRNA abundance <= 50% GR00343-S 9.4 DRD1 DRD2 DRD3 DRD4 DUSP26 EPHA5

MGI Mouse Phenotypes related to Drug Psychosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
2 homeostasis/metabolism MP:0005376 9.93 CNR1 DRD1 DRD2 DRD3 DRD4 DUSP26
3 mortality/aging MP:0010768 9.7 CNR1 DRD1 DRD2 DRD3 DRD5 FOS
4 nervous system MP:0003631 9.36 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5

Drugs & Therapeutics for Drug Psychosis

Drugs for Drug Psychosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tranquilizing Agents Phase 4,Not Applicable
2 Antipsychotic Agents Phase 4,Not Applicable
3 Central Nervous System Depressants Phase 4,Not Applicable
4 Antidepressive Agents Phase 4
5 Psychotropic Drugs Phase 4,Not Applicable
6 Quetiapine Fumarate Phase 4 111974-72-2
7
Clozapine Approved Not Applicable 5786-21-0 2818
8 Neurotransmitter Agents Not Applicable
9 GABA Agents Not Applicable
10 Serotonin Antagonists Not Applicable
11 Serotonin Agents Not Applicable
12
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry Unknown status NCT00986167 Phase 4 Quetiapine XR
2 Study of Clozapine for the Treatment of Psychosis in Patients With Idiopathic Parkinson's Disease Completed NCT00004826 Not Applicable clozapine

Search NIH Clinical Center for Drug Psychosis

Cochrane evidence based reviews: psychoses, substance-induced

Genetic Tests for Drug Psychosis

Anatomical Context for Drug Psychosis

Publications for Drug Psychosis

Articles related to Drug Psychosis:

# Title Authors Year
1
Analysis of overall gene expression induced by amphetamine and phencyclidine: novel targets for the treatment of drug psychosis and schizophrenia. ( 11812256 )
2002

Variations for Drug Psychosis

Expression for Drug Psychosis

Search GEO for disease gene expression data for Drug Psychosis.

Pathways for Drug Psychosis

Pathways related to Drug Psychosis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
2
Show member pathways
12.86 CNR1 DRD1 DRD2 FOS HTR2A
3
Show member pathways
12.8 DRD1 DRD2 DRD3 DRD4 DRD5 FOS
4
Show member pathways
12.58 DRD1 DRD2 DRD3 DRD4 DRD5 FOS
5
Show member pathways
12.34 CNR1 DRD1 GABRR3 NDUFS4
7 12.08 DRD1 DRD2 DRD3 DRD4 DRD5
8 11.98 DRD1 DRD2 DRD5 FOS HTR1A
9
Show member pathways
11.95 DRD1 DRD2 DRD4 DRD5
10
Show member pathways
11.78 DRD1 DRD2 FOS
11
Show member pathways
11.69 DRD2 DRD3 DRD4
12 11.68 CNR1 DRD3 DRD4 HTR2A
13
Show member pathways
11.21 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1A
14
Show member pathways
10.61 IDH1 IDH2
15 10.6 DRD1 DRD2 DRD3 DRD5

GO Terms for Drug Psychosis

Cellular components related to Drug Psychosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.85 DRD2 DRD4 EPHA5 HTR1A HTR2A
2 axon GO:0030424 9.77 CNR1 DRD2 EPHA5 HTR2A PINK1
3 glutamatergic synapse GO:0098978 9.63 CNR1 DRD1 DRD2 DRD3 DRD4 HTR2A
4 ciliary membrane GO:0060170 9.61 DRD1 DRD2 DRD5
5 integral component of postsynaptic membrane GO:0099055 9.58 DRD1 DRD2 HTR2A
6 GABA-ergic synapse GO:0098982 9.56 CNR1 DRD1 DRD2 DRD3
7 non-motile cilium GO:0097730 9.5 DRD1 DRD2 DRD5
8 dopaminergic synapse GO:0098691 9.48 DRD2 DRD3
9 integral component of plasma membrane GO:0005887 9.32 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
10 integral component of presynaptic membrane GO:0099056 9.26 CNR1 DRD1 DRD2 HTR2A
11 membrane GO:0016020 10.34 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5

Biological processes related to Drug Psychosis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.9 CNR1 DRD2 DRD3
2 locomotory behavior GO:0007626 9.89 DRD1 DRD2 DRD3
3 memory GO:0007613 9.89 CNR1 DRD1 HTR2A
4 cellular calcium ion homeostasis GO:0006874 9.89 DRD3 DRD4 DRD5 HTR2A
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 DRD2 HTR2A PHB2
6 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.86 CNR1 DRD2 DRD3
7 regulation of synaptic vesicle exocytosis GO:2000300 9.85 DRD1 DRD2 HTR2A
8 visual learning GO:0008542 9.84 DRD1 DRD2 DRD3
9 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.81 DRD4 HTR1A HTR2A
10 associative learning GO:0008306 9.81 DRD1 DRD2 DRD5
11 behavioral fear response GO:0001662 9.8 DRD1 DRD4 HTR1A
12 response to morphine GO:0043278 9.8 CNR1 DRD2 DRD3
13 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.8 CNR1 DRD1 DRD4 HTR1A HTR2A
14 arachidonic acid secretion GO:0050482 9.78 DRD2 DRD3 DRD4
15 temperature homeostasis GO:0001659 9.76 DRD1 DRD2 HTR2A
16 negative regulation of blood pressure GO:0045776 9.76 CNR1 DRD2 DRD3 DRD5
17 negative regulation of protein secretion GO:0050709 9.75 DRD2 DRD3 DRD4
18 2-oxoglutarate metabolic process GO:0006103 9.74 IDH1 IDH2
19 prepulse inhibition GO:0060134 9.74 DRD1 DRD2 DRD3
20 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.73 DRD2 DRD3
21 positive regulation of kinase activity GO:0033674 9.73 DRD4 HTR2A
22 transmission of nerve impulse GO:0019226 9.73 DRD1 DRD5
23 long-term synaptic depression GO:0060292 9.73 DRD1 DRD5
24 striatum development GO:0021756 9.73 DRD1 DRD2
25 grooming behavior GO:0007625 9.72 DRD1 DRD2
26 positive regulation of renal sodium excretion GO:0035815 9.72 DRD2 DRD3
27 regulation of synaptic transmission, GABAergic GO:0032228 9.72 CNR1 DRD2
28 G protein-coupled receptor internalization GO:0002031 9.72 DRD2 DRD3
29 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.72 DRD1 DRD3 DRD5
30 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.71 DRD3 DRD4
31 sleep GO:0030431 9.71 FOS HTR2A
32 peristalsis GO:0030432 9.71 DRD1 DRD2
33 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.71 DRD2 DRD3 DRD4
34 behavior GO:0007610 9.7 HTR1A HTR2A
35 behavioral response to ethanol GO:0048149 9.7 DRD2 DRD4
36 NADP metabolic process GO:0006739 9.7 IDH1 IDH2
37 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.7 DRD2 HTR2A
38 regulation of dopamine metabolic process GO:0042053 9.7 DRD1 DRD4 HTR1A
39 negative regulation of voltage-gated calcium channel activity GO:1901386 9.69 DRD2 DRD4
40 serotonin receptor signaling pathway GO:0007210 9.69 HTR1A HTR2A
41 mating behavior GO:0007617 9.69 DRD1 DRD5
42 cellular response to catecholamine stimulus GO:0071870 9.68 DRD1 DRD5
43 cerebral cortex GABAergic interneuron migration GO:0021853 9.68 DRD1 DRD2
44 conditioned taste aversion GO:0001661 9.67 DRD1 FOS
45 isocitrate metabolic process GO:0006102 9.67 IDH1 IDH2
46 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.67 DRD1 DRD2 DRD5
47 dopamine receptor signaling pathway GO:0007212 9.67 DRD1 DRD2 DRD3 DRD4
48 negative regulation of dopamine receptor signaling pathway GO:0060160 9.66 DRD2 DRD3
49 acid secretion GO:0046717 9.65 DRD2 DRD3
50 negative regulation of dopamine secretion GO:0033602 9.65 CNR1 DRD2

Molecular functions related to Drug Psychosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.92 CNR1 DRD1 DRD2 DRD3 DRD4 DRD5
2 neurotransmitter receptor activity GO:0030594 9.67 DRD4 HTR1A HTR2A
3 G protein-coupled serotonin receptor activity GO:0004993 9.65 DRD4 HTR1A HTR2A
4 drug binding GO:0008144 9.55 CNR1 DRD2 DRD3 DRD4 HTR2A
5 G-protein alpha-subunit binding GO:0001965 9.54 DRD1 DRD5 HTR2A
6 adrenergic receptor activity GO:0004935 9.52 DRD2 DRD3
7 serotonin binding GO:0051378 9.51 HTR1A HTR2A
8 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.46 DRD1 DRD5
9 isocitrate dehydrogenase (NADP+) activity GO:0004450 9.43 IDH1 IDH2
10 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.43 DRD2 DRD3 DRD4
11 isocitrate dehydrogenase activity GO:0004448 9.4 IDH1 IDH2
12 dopamine binding GO:0035240 9.35 DRD1 DRD2 DRD3 DRD4 DRD5
13 dopamine neurotransmitter receptor activity GO:0004952 9.02 DRD1 DRD2 DRD3 DRD4 DRD5

Sources for Drug Psychosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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