MCID: DRG001
MIFTS: 30

Drug Psychosis

Categories: Mental diseases

Aliases & Classifications for Drug Psychosis

MalaCards integrated aliases for Drug Psychosis:

Name: Drug Psychosis 12 15 17
Drug-Induced Psychotic Disorder 12
Psychoses, Substance-Induced 44
Drug-Induced Psychosis 12
Psychoses, Drug 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1742
ICD9CM 34 292.1
MeSH 44 D011605
SNOMED-CT 67 191498001
UMLS 70 C0033937

Summaries for Drug Psychosis

MalaCards based summary : Drug Psychosis, also known as drug-induced psychotic disorder, is related to substance-induced psychosis and borderline personality disorder. An important gene associated with Drug Psychosis is LHB (Luteinizing Hormone Subunit Beta), and among its related pathways/superpathways are Amphetamine addiction and Dopaminergic Neurogenesis. The drugs Dexmedetomidine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotype is taste/olfaction.

Related Diseases for Drug Psychosis

Diseases related to Drug Psychosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 substance-induced psychosis 30.9 SLC6A3 SLC18A2 LHB HTR1A DRD2 COMT
2 borderline personality disorder 29.9 SLC6A3 HTR1A DRD2 COMT
3 personality disorder 29.9 SLC6A3 HTR1A DRD2 COMT
4 psychotic disorder 29.6 SLC6A3 SLC18A2 HTR1A DRD2 COMT
5 alcohol dependence 29.5 SLC6A3 SLC18A2 HTR1A DRD2 COMT
6 parkinson disease, late-onset 29.5 SLC6A3 SLC18A2 HTR1A DRD2 COMT BCHE
7 attention deficit-hyperactivity disorder 29.3 SLC6A3 SLC18A2 HTR1A DRD2 COMT BCHE
8 polysubstance abuse 10.3 DRD2 COMT
9 tardive dyskinesia 10.3 DRD2 COMT
10 cyclothymic disorder 10.3 DRD2 COMT
11 somatization disorder 10.3 HTR1A COMT
12 intermittent explosive disorder 10.3 HTR1A COMT
13 traumatic brain injury 10.3 DRD2 COMT
14 brain injury 10.3 DRD2 COMT
15 parkinsonism 10.3
16 inhibited male orgasm 10.3 SLC6A3 HTR1A
17 neurotic disorder 10.2 HTR1A COMT
18 opioid addiction 10.2 DRD2 COMT
19 phobia, specific 10.2 HTR1A COMT
20 kleptomania 10.2 HTR1A DRD2 COMT
21 tremor 10.2
22 cannabis abuse 10.2 HTR1A DRD2 COMT
23 alexithymia 10.2 HTR1A DRD2 COMT
24 bruxism 10.2 HTR1A DRD2 COMT
25 social phobia 10.2 HTR1A DRD2 COMT
26 bipolar i disorder 10.2 HTR1A DRD2 COMT
27 opioid abuse 10.2 SLC6A3 DRD2
28 bestiality 10.2 SLC6A3 DRD2 COMT
29 schizophreniform disorder 10.2 SLC6A3 DRD2 COMT
30 schizoaffective disorder 10.2 HTR1A DRD2 COMT
31 amphetamine abuse 10.1 SLC6A3 SLC18A2
32 oppositional defiant disorder 10.1 SLC6A3 DRD2 COMT
33 heroin dependence 10.1 SLC6A3 DRD2 COMT
34 separation anxiety disorder 10.1 SLC6A3 HTR1A COMT
35 antisocial personality disorder 10.1 SLC6A3 DRD2 COMT
36 premature ejaculation 10.1 SLC6A3 HTR1A COMT
37 dysthymic disorder 10.1 SLC6A3 HTR1A COMT
38 conduct disorder 10.1 SLC6A3 DRD2 COMT
39 cocaine dependence 10.1 SLC6A3 DRD2 COMT
40 striatonigral degeneration 10.1 SLC6A3 DRD2
41 eating disorder 10.1 SLC6A3 DRD2 COMT
42 substance dependence 10.1 SLC6A3 DRD2 COMT
43 articulation disorder 10.1 SLC6A3 DRD2
44 tobacco addiction 10.1 SLC6A3 DRD2 COMT
45 withdrawal disorder 10.1 SLC6A3 HTR1A
46 mild cognitive impairment 10.0 COMT BCHE
47 choreatic disease 10.0 SLC6A3 SLC18A2 DRD2
48 impulse control disorder 10.0 SLC6A3 HTR1A DRD2 COMT
49 neuroleptic malignant syndrome 10.0 HTR1A DRD2
50 pathological gambling 10.0 SLC6A3 HTR1A DRD2 COMT

Graphical network of the top 20 diseases related to Drug Psychosis:



Diseases related to Drug Psychosis

Symptoms & Phenotypes for Drug Psychosis

MGI Mouse Phenotypes related to Drug Psychosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.8 DRD2 SLC18A2 SLC6A3

Drugs & Therapeutics for Drug Psychosis

Drugs for Drug Psychosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3
Aspartic acid Approved, Nutraceutical Phase 4 56-84-8 5960
4 Adrenergic alpha-Agonists Phase 4
5 Adrenergic Agonists Phase 4
6 Hypnotics and Sedatives Phase 4
7 Anesthetics Phase 4
8 Anesthetics, General Phase 4
9 Excitatory Amino Acid Antagonists Phase 4
10 Anesthetics, Intravenous Phase 4
11 Neurotransmitter Agents Phase 4
12 Anesthetics, Dissociative Phase 4
13 N-Methylaspartate Phase 4
14 Adrenergic Agents Phase 4
15 Analgesics Phase 4
16 Analgesics, Non-Narcotic Phase 4
17 Antipsychotic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of NMDA Antagonist-induced Psychosis and Memory Impairment in Children Completed NCT00205712 Phase 4 Ketamine;Dexmedetomidine
2 Relapse Prevention Trial in Top End Aboriginal People With Chronic Mental Illness Unknown status NCT00192582
3 Prevention of Weight Gain in Early Psychoses Completed NCT01075295
4 Effectiveness of Intensive Lifestyle Interventions in the Management of Diabetes in Individuals With Psychosis Completed NCT01828931
5 ED to EPI: Using SMS (Text) Messaging to Improve the Transition From the Emergency Department to Early Psychosis Intervention for Young People With Psychosis Recruiting NCT04298450

Search NIH Clinical Center for Drug Psychosis

Cochrane evidence based reviews: psychoses, substance-induced

Genetic Tests for Drug Psychosis

Anatomical Context for Drug Psychosis

MalaCards organs/tissues related to Drug Psychosis:

40
Brain

Publications for Drug Psychosis

Articles related to Drug Psychosis:

# Title Authors PMID Year
1
Psychiatric disorders after epilepsy diagnosis: a population-based retrospective cohort study. 61
23577079 2013
2
Suicide of a man with known allergy to fish protein by ingesting tinned fish. 61
22721933 2012
3
Comorbidity between substance use disorders and psychiatric conditions. 61
16930163 2006
4
Pathways to care in a New Zealand first-episode of psychosis cohort. 61
16683968 2006
5
Long-term use of VA mental health services by older patients with substance use disorders. 61
12096166 2002
6
Analysis of overall gene expression induced by amphetamine and phencyclidine: novel targets for the treatment of drug psychosis and schizophrenia. 61
11812256 2002
7
Diagnostic subgroups and predictors of one-year re-admission among late-middle-aged and older substance abuse patients. 61
8189738 1994
8
Psychiatric complications of Erimin abuse. 61
2595393 1989
9
[Bromism--an overlooked disease picture]. 61
3822020 1986
10
[Psychopathology of acute organophosphorus compound poisonings]. 61
7324671 1981

Variations for Drug Psychosis

Expression for Drug Psychosis

Search GEO for disease gene expression data for Drug Psychosis.

Pathways for Drug Psychosis

GO Terms for Drug Psychosis

Cellular components related to Drug Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dopaminergic synapse GO:0098691 8.8 SLC6A3 SLC18A2 DRD2

Biological processes related to Drug Psychosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.76 SLC6A3 DRD2 COMT BCHE
2 locomotory behavior GO:0007626 9.58 SLC6A3 SLC18A2 DRD2
3 response to nicotine GO:0035094 9.55 SLC6A3 DRD2
4 positive regulation of multicellular organism growth GO:0040018 9.54 SLC6A3 DRD2
5 response to amphetamine GO:0001975 9.52 SLC18A2 DRD2
6 response to iron ion GO:0010039 9.51 SLC6A3 DRD2
7 dopamine metabolic process GO:0042417 9.49 DRD2 COMT
8 prepulse inhibition GO:0060134 9.48 SLC6A3 DRD2
9 negative regulation of synaptic transmission GO:0050805 9.43 DRD2 BCHE
10 dopamine catabolic process GO:0042420 9.37 SLC6A3 COMT
11 regulation of dopamine metabolic process GO:0042053 9.32 SLC6A3 HTR1A
12 monoamine transport GO:0015844 9.26 SLC6A3 SLC18A2
13 adenohypophysis development GO:0021984 9.16 SLC6A3 DRD2
14 hyaloid vascular plexus regression GO:1990384 8.96 SLC6A3 DRD2
15 dopamine transport GO:0015872 8.62 SLC6A3 SLC18A2

Molecular functions related to Drug Psychosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monoamine transmembrane transporter activity GO:0008504 8.96 SLC6A3 SLC18A2
2 dopamine binding GO:0035240 8.62 SLC6A3 DRD2

Sources for Drug Psychosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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