MCID: DRG026
MIFTS: 52

Drug Reaction with Eosinophilia and Systemic Symptoms

Categories: Blood diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Drug Reaction with Eosinophilia and Systemic Symptoms

MalaCards integrated aliases for Drug Reaction with Eosinophilia and Systemic Symptoms:

Name: Drug Reaction with Eosinophilia and Systemic Symptoms 54
Drug Rash with Eosinophilia and Systemic Symptoms 54 60
Drug Reaction Eosinophilic Systemic Syndrome 54 60
Dress Syndrome 54 60

Characteristics:

Orphanet epidemiological data:

60
drug rash with eosinophilia and systemic symptoms
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



Summaries for Drug Reaction with Eosinophilia and Systemic Symptoms

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 139402Disease definitionDRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a hypersensitivity reaction characterized by a generalized skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6.EpidemiologyPrevalence is unknown.EtiologyOnset usually occurs 2-6 weeks after administration of the causal medication. DRESS syndrome is most frequently associated with anticonvulsants and sulfonamides but other medications (allopurinol, cyclosporine, azathioprine, gold salts and antiviral agents) have also been implicated. The manifestations may persist for several weeks after withdrawal of the causative medication.Visit the Orphanet disease page for more resources.

MalaCards based summary : Drug Reaction with Eosinophilia and Systemic Symptoms, also known as drug rash with eosinophilia and systemic symptoms, is related to severe cutaneous adverse reaction and myocarditis. An important gene associated with Drug Reaction with Eosinophilia and Systemic Symptoms is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and Downstream signaling in naive CD8+ T cells. The drugs Dapsone and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are encephalitis and fever

Wikipedia : 77 Drug reaction with eosinophilia and systemic symptoms, also termed drug-induced hypersensitivity... more...

Related Diseases for Drug Reaction with Eosinophilia and Systemic Symptoms

Diseases related to Drug Reaction with Eosinophilia and Systemic Symptoms via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
# Related Disease Score Top Affiliating Genes
1 severe cutaneous adverse reaction 30.4 HLA-B TNF
2 myocarditis 30.3 HLA-B TNF
3 exanthem 30.1 CRP TNF
4 intermediate uveitis 30.0 HLA-B TNF
5 uveitis 30.0 HLA-B TNF
6 graft-versus-host disease 29.9 HLA-B TNF
7 pneumonia 29.9 CRP TNF
8 adult-onset still's disease 29.9 CRP TNF
9 brucellosis 29.9 CRP TNF
10 familial mediterranean fever 29.8 CRP TNF
11 kawasaki disease 29.7 CRP TNF
12 panuveitis 29.5 HLA-B TNF
13 cytomegalovirus infection 29.4 HLA-B TNF
14 endocarditis 29.4 CRP TNF
15 vasculitis 29.3 CRP HLA-B TNF
16 purpura 29.3 CRP TNF
17 juvenile rheumatoid arthritis 29.3 CRP TNF
18 diabetes mellitus 29.3 CRP HLA-B TNF
19 hypereosinophilic syndrome 11.1
20 allergic hypersensitivity disease 10.6
21 hepatitis 10.4
22 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.3
23 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2
24 alopecia 10.2
25 erythema multiforme 10.2
26 interstitial nephritis 10.2
27 stevens-johnson syndrome/toxic epidermal necrolysis 10.2
28 tropical spastic paraparesis 10.1 HLA-B TNFRSF4
29 glomerulonephritis 10.1
30 acute kidney tubular necrosis 10.1
31 dermatitis 10.1
32 pancreatitis 10.1
33 exfoliative dermatitis 10.1
34 multiple sclerosis 10.0
35 myositis 10.0
36 alopecia universalis congenita 10.0
37 lung cancer 10.0
38 diabetes mellitus, insulin-dependent 10.0
39 enterocolitis 10.0
40 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0
41 basal cell carcinoma 1 10.0
42 dermatofibrosarcoma protuberans 10.0
43 kala-azar 1 10.0
44 infantile liver failure syndrome 1 10.0
45 autoinflammation with infantile enterocolitis 10.0
46 acute liver failure 10.0
47 hemophagocytic lymphohistiocytosis 10.0
48 leukemia 10.0
49 lymphoma 10.0
50 angioimmunoblastic t-cell lymphoma 10.0

Graphical network of the top 20 diseases related to Drug Reaction with Eosinophilia and Systemic Symptoms:



Diseases related to Drug Reaction with Eosinophilia and Systemic Symptoms

Symptoms & Phenotypes for Drug Reaction with Eosinophilia and Systemic Symptoms

Human phenotypes related to Drug Reaction with Eosinophilia and Systemic Symptoms:

60 33 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 encephalitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0002383
2 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
3 weight loss 60 33 hallmark (90%) Very frequent (99-80%) HP:0001824
4 thyroiditis 60 33 hallmark (90%) Very frequent (99-80%) HP:0100646
5 erythema 60 33 hallmark (90%) Very frequent (99-80%) HP:0010783
6 macule 60 33 hallmark (90%) Very frequent (99-80%) HP:0012733
7 skin rash 60 33 hallmark (90%) Very frequent (99-80%) HP:0000988
8 lymphadenopathy 60 33 hallmark (90%) Very frequent (99-80%) HP:0002716
9 erythroderma 60 33 hallmark (90%) Very frequent (99-80%) HP:0001019
10 cardiac arrest 60 33 hallmark (90%) Very frequent (99-80%) HP:0001695
11 immunologic hypersensitivity 60 33 hallmark (90%) Very frequent (99-80%) HP:0100326
12 angioedema 60 33 hallmark (90%) Very frequent (99-80%) HP:0100665
13 pulmonary infiltrates 60 33 frequent (33%) Frequent (79-30%) HP:0002113
14 interstitial pneumonitis 60 33 frequent (33%) Frequent (79-30%) HP:0006515
15 lymphocytosis 60 33 frequent (33%) Frequent (79-30%) HP:0100827
16 elevated hepatic transaminase 33 frequent (33%) HP:0002910
17 renal insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0000083
18 dyspnea 60 33 occasional (7.5%) Occasional (29-5%) HP:0002094
19 hepatitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012115
20 peripheral neuropathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0009830
21 nephrotic syndrome 60 33 occasional (7.5%) Occasional (29-5%) HP:0000100
22 myocarditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012819
23 cough 60 33 occasional (7.5%) Occasional (29-5%) HP:0012735
24 acute hepatic failure 60 33 occasional (7.5%) Occasional (29-5%) HP:0006554
25 eosinophilia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001880
26 tubulointerstitial nephritis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001970
27 pustule 60 33 occasional (7.5%) Occasional (29-5%) HP:0200039
28 enanthema 60 33 occasional (7.5%) Occasional (29-5%) HP:0030249
29 elevated hepatic transaminases 60 Frequent (79-30%)

Drugs & Therapeutics for Drug Reaction with Eosinophilia and Systemic Symptoms

Drugs for Drug Reaction with Eosinophilia and Systemic Symptoms (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dapsone Approved, Investigational Phase 4 80-08-0 2955
2
leucovorin Approved Phase 4 58-05-9 6006 143
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4 Anti-Bacterial Agents Phase 4
5 Vitamin B Complex Phase 4
6 Anti-Infective Agents Phase 4
7 Antimalarials Phase 4
8 Antiparasitic Agents Phase 4
9 Vitamin B9 Phase 4
10 Folate Phase 4
11 Antiprotozoal Agents Phase 4
12 Folic Acid Antagonists Phase 4
13 Antibodies Phase 3
14 Immunoglobulins Phase 3
15
Alprazolam Approved, Illicit, Investigational Phase 1 28981-97-7 2118
16 Central Nervous System Depressants Phase 1,Not Applicable
17 Neurotransmitter Agents Phase 1,Not Applicable
18 Psychotropic Drugs Phase 1,Not Applicable
19 Anti-Anxiety Agents Phase 1
20 GABA Modulators Phase 1
21 Hypnotics and Sedatives Phase 1
22 Tranquilizing Agents Phase 1,Not Applicable
23 GABA Agents Phase 1,Not Applicable
24
Clobetasol Approved, Experimental, Investigational Not Applicable 25122-46-7, 25122-41-2 32798 5311051
25
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
26
Allopurinol Approved Not Applicable 315-30-0 2094
27
Lamotrigine Approved, Investigational Not Applicable 84057-84-1 3878
28
Oxcarbazepine Approved Not Applicable 28721-07-5 34312
29
Valproic Acid Approved, Investigational Not Applicable 99-66-1 3121
30
Carbamazepine Approved, Investigational Not Applicable 298-46-4 2554
31
Eslicarbazepine acetate Approved Not Applicable 75970-99-9, 236395-14-5 123618
32
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
33
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
34
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
35
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
36
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
37
tannic acid Approved Not Applicable 1401-55-4
38
Etanercept Approved, Investigational Not Applicable 185243-69-0
39
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
40
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
41 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
42 glucocorticoids Not Applicable
43 Dermatologic Agents Not Applicable
44 Emollients Not Applicable
45 Antineoplastic Agents, Hormonal Not Applicable
46 Hormone Antagonists Not Applicable
47 Hormones Not Applicable
48 Anti-Inflammatory Agents Not Applicable
49 Antioxidants Not Applicable
50 Antimetabolites Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
2 Treatment of Hypersensitivity Syndrome (DRESS) With Tegeline® (Human Immunoglobulin) Terminated NCT00505648 Phase 3 Tegeline®
3 A Study of the Abuse Liability Potential of Cenobamate in Recreational Drug Users Completed NCT03509285 Phase 1 Alprazolam Placebo;Cenobamate placebo;Alprazolam;Cenobamate
4 Comparison Between Corticosteroid and Topical Steroids in the DRESS Unknown status NCT01987076 Not Applicable Prednisone;Clobetasol
5 HLA-B*5801 Screening to Prevent Allopurinol-induced Severe Cutaneous Adverse Reaction Unknown status NCT03046914 Not Applicable
6 Immunological and Viral Parameters in Patients Receiving Anti-epileptic Drugs Completed NCT02556320 Not Applicable anti-epileptic drug
7 Evaluation of TNF-α Blockade Effect in Patients With Severe Cutaneous Adverse Drug Reactions Completed NCT01276314 Not Applicable anti- TNF-a;Prednisolone
8 T Cell Response in Hypersensitivity Syndrome Completed NCT00213447
9 Severe Cutaneous Adverse Reactions in Thailand Recruiting NCT02574988
10 An Exploratory Study of Genetic and Clinical Factors for Serious Skin Reactions Among Users of Eslicarbazepine Acetate Recruiting NCT02520557
11 Survey Study for Velaglucerase Alfa (VPRIV) in Japan Recruiting NCT03625882
12 Multiple Drug Hypersensitivity Syndrome Not yet recruiting NCT03784482

Search NIH Clinical Center for Drug Reaction with Eosinophilia and Systemic Symptoms

Genetic Tests for Drug Reaction with Eosinophilia and Systemic Symptoms

Anatomical Context for Drug Reaction with Eosinophilia and Systemic Symptoms

MalaCards organs/tissues related to Drug Reaction with Eosinophilia and Systemic Symptoms:

42
Skin, T Cells, Testes, Thyroid, Liver, Thymus, Eye

Publications for Drug Reaction with Eosinophilia and Systemic Symptoms

Articles related to Drug Reaction with Eosinophilia and Systemic Symptoms:

(show top 50) (show all 330)
# Title Authors Year
1
Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS): How Far Have We Come? ( 30652265 )
2019
2
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms due to lamotrigine differs from that due to other drugs. ( 30663091 )
2019
3
Facial pustules due to drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms may histopathologically mimic eosinophilic pustular folliculitis: a case report. ( 30666704 )
2019
4
Comments on: Abnormal erythrocyte morphology in drug reaction with eosinophilia and systemic symptoms. ( 30685268 )
2019
5
Increased type 2 innate lymphoid cells in patients with drug reaction with eosinophilia and systemic symptom. ( 30735685 )
2019
6
Erythema Gyratum Repens as a Manifestation of Drug Reaction with Eosinophilia and Systemic Symptoms. ( 30745644 )
2019
7
HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms. ( 30776417 )
2019
8
Drug reaction with eosinophilia and systemic symptoms (DRESS) in children. ( 30830064 )
2019
9
Can we allow a further intake of drugs poorly suspected as responsible in responsible in drug reaction with eosinophilia and systemic symptoms (DRESS)? A study of practice. ( 30834582 )
2019
10
Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome associated with Ethambutol use: A Case Report. ( 30848209 )
2019
11
Drug reaction with eosinophilia and systemic symptoms presenting as leukoencephalopathy. ( 30868617 )
2019
12
A Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome Associated With Clobazam. ( 30870346 )
2019
13
Oxacillin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). ( 30877266 )
2019
14
Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS Syndrome). ( 30879852 )
2019
15
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by imatinib. ( 30706827 )
2019
16
Relapsing Course of Sulfasalazine-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Complicated by Alopecia Universalis and Vitiligo. ( 30578426 )
2018
17
DRESS/DIHS caused by levofloxacin in a patient with systemic scleroderma, rheumatoid arthritis, and Sjogren syndrome. ( 30484869 )
2018
18
Imatinib-induced drug reaction with eosinophilia and systemic symptoms in solid tumors: a patient with dermatofibrosarcoma protuberans and successful desensitization management. ( 30096127 )
2018
19
A familial mediterranean fever flare induced by a drug reaction with eosinophilia and systemic symptoms. ( 28653374 )
2018
20
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome successfully treated with mepolizumab. ( 29133221 )
2018
21
Serum thymus and activation-regulated chemokine is associated with the severity of drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome. ( 29150836 )
2018
22
Clinical, Viral and Genetic Characteristics of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in Shanghai, China. ( 29242946 )
2018
23
Sensitivity and specificity of the lymphocyte transformation test in drug reaction with eosinophilia and systemic symptoms causality assessment. ( 29265576 )
2018
24
Use of antiviral medications in drug reaction with eosinophilia and systemic symptoms (DRESS): A case of infantile DRESS. ( 29334124 )
2018
25
Lamotrigine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) during primary Epstein-Barr virus (EBV) infection. ( 29367368 )
2018
26
Paediatric case series of drug reaction with eosinophilia and systemic symptoms (DRESS): 12-year experience at a single referral centre in Hong Kong and the first reported use of infliximab. ( 29384118 )
2018
27
Drug Reaction with Eosinophilia and Systemic Symptoms Associated with Reactivation of Epstein-Barr Virus and/or Cytomegalovirus Leading to Hemophagocytic Syndrome in One of Two Patients. ( 29386835 )
2018
28
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: Case report of severe multiorgan involvement to perindopril/amlodipine combination antihypertensive. ( 29387775 )
2018
29
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Secondary to Furosemide: Case Report and Review of Literature. ( 29440628 )
2018
30
Dapsone-induced drug reaction with eosinophilia and systemic symptoms associated with HLA-B*13:01. ( 29512326 )
2018
31
Overexpression of cytotoxic proteins correlates with liver function impairment in patients with drug reaction with eosinophilia and systemic symptoms (DRESS). ( 29521632 )
2018
32
Drug Reaction with Eosinophilia and Systemic Symptoms: An Update and Review of Recent Literature. ( 29527023 )
2018
33
Up-regulation of Human Herpesvirus 6B-derived microRNAs in the Serum of Patients with Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms. ( 29542806 )
2018
34
Cytomegalovirus (CMV) hepatitis: an uncommon complication of CMV reactivation in drug reaction with eosinophilia and systemic symptoms. ( 29568844 )
2018
35
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome due to ethambutol. ( 29602678 )
2018
36
Drug reaction with eosinophilia and systemic symptoms syndrome induced by benznidazole. ( 29635801 )
2018
37
C-Reactive Protein and Procalcitonin in Case Reports of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. ( 29656292 )
2018
38
Drug reaction with eosinophilia and systemic symptoms: DRESS syndrome. ( 29687681 )
2018
39
Classic autoimmune type 1 diabetes mellitus after a case of drug reaction with eosinophilia and systemic symptoms (DRESS). ( 29693052 )
2018
40
Recent Advances in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms. ( 29744372 )
2018
41
Author's reply: Cytomegalovirus (CMV) hepatitis: an uncommon complication of CMV reactivation in drug reaction with eosinophilia and systemic symptoms. ( 29796687 )
2018
42
Comment on: Cytomegalovirus (CMV) hepatitis: an uncommon complication of CMV reactivation in drug reaction with eosinophilia and systemic symptoms. ( 29799057 )
2018
43
Drug reaction with eosinophilia and systemic symptoms after daclizumab therapy. ( 29934423 )
2018
44
Drug reaction with eosinophilia and systemic symptoms caused by spironolactone: Case report. ( 30009386 )
2018
45
Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. ( 30023418 )
2018
46
Drug reaction with eosinophilia and systemic symptoms after daclizumab therapy in MS. ( 30027105 )
2018
47
Predictors of disease severity in drug reaction with eosinophilia and systemic symptoms. ( 30058562 )
2018
48
A Rare Case of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Glimepiride, the Unlikely Culprit. ( 30069245 )
2018
49
DRESS syndrome induced by the combination of vemurafenib and cobimetinib in melanoma: a series of 11 cases. ( 30081108 )
2018
50
Prevalence, risk factors, and mortality outcome in the drug reaction with eosinophilia and systemic symptoms patients with cardiac involvement. ( 30099742 )
2018

Variations for Drug Reaction with Eosinophilia and Systemic Symptoms

Expression for Drug Reaction with Eosinophilia and Systemic Symptoms

Search GEO for disease gene expression data for Drug Reaction with Eosinophilia and Systemic Symptoms.

Pathways for Drug Reaction with Eosinophilia and Systemic Symptoms

Pathways related to Drug Reaction with Eosinophilia and Systemic Symptoms according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.02 TNF TNFRSF4
2
Show member pathways
10.74 TNF TNFRSF4
3 9.9 CRP TNF

GO Terms for Drug Reaction with Eosinophilia and Systemic Symptoms

Cellular components related to Drug Reaction with Eosinophilia and Systemic Symptoms according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 HLA-B TNF TNFRSF4

Biological processes related to Drug Reaction with Eosinophilia and Systemic Symptoms according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 HLA-B TNF TNFRSF4
2 defense response to Gram-positive bacterium GO:0050830 9.32 CRP TNF
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.26 TNF TNFRSF4
4 inflammatory response GO:0006954 9.13 CRP TNF TNFRSF4
5 negative regulation of lipid storage GO:0010888 8.62 CRP TNF

Sources for Drug Reaction with Eosinophilia and Systemic Symptoms

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10 dbSNP
11 DGIdb
17 EFO
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20 FMA
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30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
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45 MeSH
46 MESH via Orphanet
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50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
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75 UMLS via Orphanet
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