MCID: DRG026
MIFTS: 45

Drug Reaction with Eosinophilia and Systemic Symptoms

Categories: Blood diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Drug Reaction with Eosinophilia and Systemic Symptoms

MalaCards integrated aliases for Drug Reaction with Eosinophilia and Systemic Symptoms:

Name: Drug Reaction with Eosinophilia and Systemic Symptoms 20
Drug Rash with Eosinophilia and Systemic Symptoms 20 58
Drug Reaction Eosinophilic Systemic Syndrome 20 58
Dress Syndrome 20 58
Drug Hypersensitivity Syndrome 70

Characteristics:

Orphanet epidemiological data:

58
drug rash with eosinophilia and systemic symptoms
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare skin diseases
Rare allergic disease


Summaries for Drug Reaction with Eosinophilia and Systemic Symptoms

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 139402 Definition A rare hypersensitivity reaction characterized by a generalized skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6. Epidemiology Prevalence is unknown. Etiology Onset usually occurs 2-6 weeks after administration of the causal medication. DRESS syndrome is most frequently associated with anticonvulsants and sulfonamides but other medications (allopurinol, cyclosporine, azathioprine, gold salts and antiviral agents) have also been implicated. The manifestations may persist for several weeks after withdrawal of the causative medication.

MalaCards based summary : Drug Reaction with Eosinophilia and Systemic Symptoms, also known as drug rash with eosinophilia and systemic symptoms, is related to exanthem and thyroiditis. An important gene associated with Drug Reaction with Eosinophilia and Systemic Symptoms is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs Immunoglobulins and Immunoglobulins, Intravenous have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and bone, and related phenotypes are encephalitis and fever

Wikipedia : 73 Drug reaction with eosinophilia and systemic symptoms (DRESS), also termed drug-induced hypersensitivity... more...

Related Diseases for Drug Reaction with Eosinophilia and Systemic Symptoms

Diseases related to Drug Reaction with Eosinophilia and Systemic Symptoms via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 504)
# Related Disease Score Top Affiliating Genes
1 exanthem 31.6 TNF CRP
2 thyroiditis 30.8 TNF CRP
3 myocarditis 30.6 TNF HLA-B
4 severe cutaneous adverse reaction 30.6 TNF HLA-B CRP
5 vitiligo-associated multiple autoimmune disease susceptibility 1 30.6 TNF HLA-B
6 uveitis 30.5 TNF HLA-B
7 graft-versus-host disease 30.4 TNF HLA-B
8 alopecia areata 30.4 TNF HLA-B
9 toxic shock syndrome 30.3 TNF CRP
10 endocarditis 30.3 TNF CRP
11 conjunctivitis 30.2 TNF HLA-B
12 intermediate uveitis 30.2 TNF HLA-B
13 lymph node tuberculosis 30.2 TNF CRP
14 herpes zoster 30.1 TNF HLA-B
15 pyelonephritis 30.1 TNF CRP
16 facial paralysis 30.1 TNF CRP
17 pharyngitis 30.1 TNF CRP
18 osteomyelitis 30.1 TNF CRP
19 cellulitis 30.1 TNF CRP
20 rubella 30.1 TNF HLA-B
21 adult-onset still's disease 30.1 TNF CRP
22 rosacea 30.1 TNF CRP
23 infective endocarditis 30.1 TNF CRP
24 chronic urticaria 30.1 TNF CRP
25 brucellosis 30.1 TNF CRP
26 pericarditis 30.1 TNF CRP
27 alcoholic hepatitis 30.0 TNF CRP
28 purpura 30.0 TNF CRP
29 lymphadenitis 30.0 TNF CRP
30 familial mediterranean fever 30.0 TNF CRP
31 viral hepatitis 30.0 TNF CRP
32 arthritis 30.0 TNF HLA-B CRP
33 kawasaki disease 30.0 TNF CRP
34 thrombocytopenia 29.9 TNF HLA-B CRP
35 cholangitis 29.8 TNF HLA-B CRP
36 autoimmune disease 29.8 TNFRSF4 TNF HLA-B CRP
37 septic arthritis 29.7 TNF CRP
38 vasculitis 29.7 TNF HLA-B CRP
39 meningoencephalitis 29.7 TNF CRP
40 mental depression 29.7 TNF CRP
41 immune deficiency disease 29.6 TNF HLA-B CRP
42 acute pancreatitis 29.6 TNF CRP
43 syphilis 29.6 TNF CRP
44 pustulosis of palm and sole 29.6 TNF CRP
45 chorioretinitis 29.5 TNF CRP
46 enthesopathy 29.5 TNF CRP
47 viral pneumonia 29.5 TNF CRP
48 endophthalmitis 29.5 TNF CRP
49 acute cystitis 29.5 TNF CRP
50 obstructive jaundice 29.5 TNF CRP

Graphical network of the top 20 diseases related to Drug Reaction with Eosinophilia and Systemic Symptoms:



Diseases related to Drug Reaction with Eosinophilia and Systemic Symptoms

Symptoms & Phenotypes for Drug Reaction with Eosinophilia and Systemic Symptoms

Human phenotypes related to Drug Reaction with Eosinophilia and Systemic Symptoms:

58 31 (show all 28)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 encephalitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002383
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 thyroiditis 58 31 hallmark (90%) Very frequent (99-80%) HP:0100646
4 erythema 58 31 hallmark (90%) Very frequent (99-80%) HP:0010783
5 macule 58 31 hallmark (90%) Very frequent (99-80%) HP:0012733
6 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
7 weight loss 58 31 hallmark (90%) Very frequent (99-80%) HP:0001824
8 erythroderma 58 31 hallmark (90%) Very frequent (99-80%) HP:0001019
9 immunologic hypersensitivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0100326
10 lymphadenopathy 58 31 hallmark (90%) Very frequent (99-80%) HP:0002716
11 angioedema 58 31 hallmark (90%) Very frequent (99-80%) HP:0100665
12 cardiac arrest 58 31 hallmark (90%) Very frequent (99-80%) HP:0001695
13 elevated hepatic transaminase 58 31 frequent (33%) Frequent (79-30%) HP:0002910
14 pulmonary infiltrates 58 31 frequent (33%) Frequent (79-30%) HP:0002113
15 lymphocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0100827
16 interstitial pneumonitis 58 31 frequent (33%) Frequent (79-30%) HP:0006515
17 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
18 hepatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012115
19 nephrotic syndrome 58 31 occasional (7.5%) Occasional (29-5%) HP:0000100
20 dyspnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002094
21 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
22 peripheral neuropathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0009830
23 myocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012819
24 eosinophilia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001880
25 pustule 58 31 occasional (7.5%) Occasional (29-5%) HP:0200039
26 tubulointerstitial nephritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001970
27 acute hepatic failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0006554
28 enanthema 58 31 occasional (7.5%) Occasional (29-5%) HP:0030249

Drugs & Therapeutics for Drug Reaction with Eosinophilia and Systemic Symptoms

Drugs for Drug Reaction with Eosinophilia and Systemic Symptoms (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Immunoglobulins, Intravenous Phase 3
3 Antibodies Phase 3
4
Prednisone Approved, Vet_approved 53-03-2 5865
5
Clobetasol Approved, Experimental, Investigational 25122-46-7, 25122-41-2 32798 5311051
6
Eslicarbazepine acetate Approved 236395-14-5, 75970-99-9 123618
7
Oxcarbazepine Approved 28721-07-5 34312
8
Valproic acid Approved, Investigational 99-66-1 3121
9
Lamotrigine Approved, Investigational 84057-84-1 3878
10
Carbamazepine Approved, Investigational 298-46-4 2554
11 Hormones
12 Hormone Antagonists
13 Emollients
14 glucocorticoids
15 Anti-Inflammatory Agents
16 Antineoplastic Agents, Hormonal
17 Anti-Bacterial Agents
18 Antibiotics, Antitubercular
19 Anticonvulsants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of DRESS (Drug Reaction With Eosinophilia and Systemic Symptoms) With Tegeline® Terminated NCT00505648 Phase 3 Tegeline®
2 DRESS - Setting of Corticosteroid Treatment. Unknown status NCT01987076 Prednisone;Clobetasol
3 The Multicenter Registry of Patients With Severe Cutaneous Adverse Reactions Among Tertiary Medical Institutes in Thailand Unknown status NCT02574988
4 Multiple Drug Hypersensitivity Syndrome in a Large Database Completed NCT03784482
5 Immunological and Viral Parameters in Patients Receiving Anti-epileptic Drugs Completed NCT02556320 anti-epileptic drug
6 Origin and Function of Eosinophilic Polynuclear During Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Recruiting NCT04330118

Search NIH Clinical Center for Drug Reaction with Eosinophilia and Systemic Symptoms

Genetic Tests for Drug Reaction with Eosinophilia and Systemic Symptoms

Anatomical Context for Drug Reaction with Eosinophilia and Systemic Symptoms

MalaCards organs/tissues related to Drug Reaction with Eosinophilia and Systemic Symptoms:

40
Lung, Kidney, Bone, Liver, Skin, Myeloid, Lymph Node

Publications for Drug Reaction with Eosinophilia and Systemic Symptoms

Articles related to Drug Reaction with Eosinophilia and Systemic Symptoms:

(show top 50) (show all 639)
# Title Authors PMID Year
1
Strontium citrate associated drug reaction with eosinophilia and systemic symptoms syndrome with granulomatous dermatitis. 61
33778142 2021
2
Reactivation of drug reaction with eosinophilia and systemic symptoms with ranitidine patch testing. 61
33104238 2021
3
Atypical presentation of lamotrigine-induced drug reaction with eosinophilia and systemic symptoms. 61
33583112 2021
4
Trimetazidine, a hitherto unreported cause of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome. 61
33034892 2021
5
Monitoring of human herpesvirus 6 infection in the management of drug reaction with eosinophilia and systemic symptoms. 61
32608082 2021
6
Cenobamate: A New Adjunctive Agent for Drug-Resistant Focal Onset Epilepsy. 61
32623899 2021
7
Severe Cutaneous Adverse Reactions to Anti-tuberculosis Drugs in Korean Patients. 61
33474859 2021
8
Evaluation of drug patch tests in children. 61
33685563 2021
9
Potentially life‑threatening severe cutaneous adverse reactions associated with tyrosine kinase inhibitors (Review). 61
33650659 2021
10
Viral rashes mimicking drug reaction with eosinophilia and systemic symptoms syndrome in children after β-lactams intake: a diagnostic challenge. 61
33686529 2021
11
Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review. 61
33025080 2021
12
Complicated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome History in a 14-Year-Old. 61
33622999 2021
13
Drug reaction with eosinophilia and systemic symptoms (DRESS)-associated hemophagocytic lymphohistiocytosis (HLH), an important and underrecognized HLH mimic: A case report. 61
32808435 2021
14
A Nationwide Study of Severe Cutaneous Adverse Reactions Based on the Multicenter Registry in Korea. 61
32961314 2021
15
Severe cutaneous adverse reaction associated with antiseizure medications: Diagnosis, management, and prevention. 61
33639435 2021
16
Current Perspective Regarding the Immunopathogenesis of Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS/DRESS). 61
33670052 2021
17
Comment on 'Drug reaction with eosinophilia and systemic symptoms syndrome in a patient with COVID-19': involvement of herpesvirus reactivations and adverse drug reactions in diverse cutaneous manifestations and overall disease severity of COVID-19. 61
32970885 2021
18
Familial drug reaction with eosinophilia and systemic symptoms syndrome. 61
33666061 2021
19
Safety profiles of new xanthine oxidase inhibitors: A post-marketing study. 61
33560211 2021
20
Pediatric drug reaction with eosinophilia and systemic symptoms: A systematic review of the literature, with a focus on relapsing cases. 61
33155729 2021
21
Teriflunomide-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. 61
32557734 2021
22
Autoimmune hepatitis as a sequelae of oxcarbazepine-induced drug reaction with eosinophilia and systemic symptoms. 61
32791246 2021
23
Drug Reaction with Eosinophilia and Systemic Symptoms: A Complex Interplay between Drug, T Cells, and Herpesviridae. 61
33498771 2021
24
When fever is more than infection: two cases of vancomycin-induced drug reaction with eosinophilia and systemic symptoms (DRESS). 61
33414117 2021
25
Drug reaction with eosinophilia and systemic symptoms: A single center descriptive observational study. 61
33314590 2021
26
Adverse Reactions Induced by Minocycline: A Review of Literature. 61
33494681 2021
27
Early high-dose intravenous corticosteroids rapidly arrest Stevens Johnson syndrome and drug reaction with eosinophilia and systemic symptoms recurrence on drug re-exposure. 61
32835874 2021
28
A 51-Year-Old Woman with Drug-Induced Hypersensitivity Syndrome Associated with Carbamazepine, Reactivation of Human Herpesvirus 6, and Acute Liver Failure: A Case Report. 61
33504758 2021
29
The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity. 61
33717075 2021
30
The Role of In Vivo and Ex Vivo Diagnostic Tools in Severe Delayed Immune-Mediated Adverse Antibiotic Drug Reactions. 61
33453452 2021
31
Dermoscopic Aspects of Cutaneous Adverse Drug Reactions. 61
33614215 2021
32
Drug reaction with eosinophilia and systemic symptoms syndrome secondary to acetazolamide associated with markedly elevated procalcitonin. 61
33462002 2021
33
An Uncommon Presentation of DRESS Syndrome Secondary to Leflunomide Use: A Case Report. 61
33629602 2021
34
Dapsone-induced DRESS after infliximab-induced vasculitis: a case of cerebral infarction in the context of multiple drug reactions. 61
33334758 2020
35
Granulysin-Based Lymphocyte Activation Test for Evaluating Drug Causality in Antiepileptics-Induced Severe Cutaneous Adverse Reactions. 61
33340500 2020
36
DRESS syndrome following furosemide administration: An unusual association. 61
33203615 2020
37
Anti-tubercular therapy causing Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome. 61
33469620 2020
38
Drug reaction with eosinophilia and systemic symptoms syndrome in a patient with COVID-19. 61
32735713 2020
39
Severe acute generalized exanthematous pustulosis (AGEP) induced by miconazole oral gel with overlapping features of drug reaction with eosinophilia and systemic symptoms (DRESS). 61
33382118 2020
40
Trimethoprim-induced drug reaction with eosinophilia and systemic symptoms (DRESS) associated with reactivation of human herpes virus-6 (HHV-6) leading to acute liver failure. 61
33363781 2020
41
Alectinib-associated drug reaction with eosinophilia and systemic symptoms syndrome. 61
33304973 2020
42
Drug reaction with eosinophilia and systemic symptoms due to agomelatine. 61
33216948 2020
43
Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement. 61
32944113 2020
44
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. 61
33341203 2020
45
Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS). 61
33292540 2020
46
Sildenafil-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: Case report with review. 61
32543093 2020
47
Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes. 61
32452529 2020
48
The interferon-γ-induced protein 10/CXCR3 axis is associated with human herpesvirus-6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms. 61
32037509 2020
49
Drug reaction with eosinophilia and systemic symptoms (DRESS) in the pediatric population: A systematic review of the literature. 61
32247873 2020
50
Furosemide-Associated Drug Reaction With Eosinophilia and Systemic Symptoms. 61
33021525 2020

Variations for Drug Reaction with Eosinophilia and Systemic Symptoms

Expression for Drug Reaction with Eosinophilia and Systemic Symptoms

Search GEO for disease gene expression data for Drug Reaction with Eosinophilia and Systemic Symptoms.

Pathways for Drug Reaction with Eosinophilia and Systemic Symptoms

Pathways related to Drug Reaction with Eosinophilia and Systemic Symptoms according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.24 TNFRSF4 TNF
2
Show member pathways
11.12 TNFRSF4 TNF
3 10.98 TNFRSF4 TNF
4
Show member pathways
10.74 TNFRSF4 TNF
5 9.9 TNF CRP

GO Terms for Drug Reaction with Eosinophilia and Systemic Symptoms

Cellular components related to Drug Reaction with Eosinophilia and Systemic Symptoms according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 TNFRSF4 TNF HLA-B

Biological processes related to Drug Reaction with Eosinophilia and Systemic Symptoms according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.33 TNFRSF4 TNF HLA-B
2 defense response to Gram-positive bacterium GO:0050830 9.26 TNF CRP
3 inflammatory response GO:0006954 9.13 TNFRSF4 TNF CRP
4 negative regulation of lipid storage GO:0010888 8.62 TNF CRP

Sources for Drug Reaction with Eosinophilia and Systemic Symptoms

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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