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MCID: DMP001
MIFTS: 46

Dumping Syndrome

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Dumping Syndrome

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MalaCards integrated aliases for Dumping Syndrome:

Name: Dumping Syndrome 12 56 45 15 17 74
Dumping 56 74
Postgastrectomy Syndromes 74
Dumping Syndrome 12
Jejunal Syndrome 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:14495
MeSH 45 D004377
NCIt 51 C2994
SNOMED-CT 69 80193009
ICD10 34 K91.1
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Summaries for Dumping Syndrome

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MalaCards based summary : Dumping Syndrome, also known as dumping, is related to hyperinsulinemic hypoglycemia and duodenal ulcer, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Dumping Syndrome is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and Aldosterone synthesis and secretion. The drugs Somatostatin and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and lung.

Wikipedia : 77 Dumping syndrome occurs when food, especially sugar, moves too quickly from the stomach to the... more...

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Related Diseases for Dumping Syndrome

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Diseases related to Dumping Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia 30.0 INS SST
2 duodenal ulcer 29.8 INS SCT SST
3 gastroesophageal reflux 29.6 GCG NTS PYY
4 constipation 29.5 NTS PYY SST
5 insulinoma 29.2 GCG INS SCT SST
6 duodenogastric reflux 29.1 NTS PYY SCT SST
7 degos 'en cocarde' erythrokeratoderma 10.4
8 hypoglycemia 10.3
9 type 1 diabetes mellitus 15 10.2 GCG INS
10 hyperinsulinemic hypoglycemia, familial, 7 10.2 GCG INS
11 maturity-onset diabetes of the young, type 9 10.2 GCG INS
12 hirata disease 10.2 GCG INS
13 acute insulin response 10.2 GCG INS
14 pancreatoblastoma 10.2 NTS SST
15 diarrhea 10.2
16 prediabetes syndrome 10.1 GCG INS
17 space motion sickness 10.1 NTS SCT
18 duodenal somatostatinoma 10.1 INS SST
19 somatostatinoma 10.1 INS SST
20 pancreatic endocrine carcinoma 10.1 INS SST
21 hyperproinsulinemia 10.1 INS SCT
22 hyperpituitarism 10.1 INS SST
23 functional gastric disease 10.1 INS SST
24 gastric cancer 10.1
25 peptic ulcer disease 10.1
26 glucagonoma 10.1 SCT SST
27 islet cell tumor 10.1 INS SST
28 angiodysplasia 10.1 SCT SST
29 pituitary-dependent cushing's disease 10.1 INS SST
30 maturity-onset diabetes of the young, type 7 10.1 INS SCT
31 duodenal gastrinoma 10.1 SCT SST
32 endocrine organ benign neoplasm 10.1 INS SST
33 steatorrhea 10.0 SCT SST
34 thyroid gland disease 10.0 INS SST
35 pituitary gland disease 10.0 INS SST
36 cell type benign neoplasm 10.0 INS SST
37 acromegaly 10.0 INS SST
38 small intestine cancer 10.0 SCT SST
39 congenital microgastria 10.0
40 hyperthyroidism 10.0 INS SST
41 pneumatosis cystoides intestinalis 10.0 PYY SST
42 microvascular complications of diabetes 1 10.0 INS SST
43 serotonin syndrome 10.0 PYY SST
44 insulin-like growth factor i 9.9 INS SST
45 endocrine gland cancer 9.9 GCG SST
46 neuroendocrine tumor 9.9 NTS SST
47 acute pancreatitis 9.9 SCT SST
48 pancreatic cystadenoma 9.9 GCG INS SST
49 gastrointestinal system benign neoplasm 9.9 GCG INS SST
50 vipoma 9.9 NTS SCT SST

Graphical network of the top 20 diseases related to Dumping Syndrome:



Diseases related to Dumping Syndrome
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Symptoms & Phenotypes for Dumping Syndrome

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UMLS symptoms related to Dumping Syndrome:


constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery
Sources

Drugs & Therapeutics for Dumping Syndrome

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Drugs for Dumping Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 4,Phase 2,Not Applicable 38916-34-6, 51110-01-1 53481605
2
lanreotide Approved Phase 4,Phase 2 108736-35-2
3
Pasireotide Approved Phase 4,Phase 2 396091-73-9 9941444
4
Lactitol Investigational Phase 4 585-86-4, 585-88-6 493591
5 Hormones Phase 4,Phase 2,Not Applicable
6 Hormone Antagonists Phase 4,Phase 2,Not Applicable
7 Angiopeptin Phase 4,Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
9 Pharmaceutical Solutions Phase 2
10
Empagliflozin Approved Not Applicable 864070-44-0
11
Loperamide Approved Not Applicable 53179-11-6 3955
12
Glucagon Approved Not Applicable 16941-32-5
13
Acetaminophen Approved 103-90-2 1983
14
Octreotide Approved, Investigational 83150-76-9 6400441 383414
15
Sulfasalazine Approved 599-79-1 5353980 5359476
16
Rifaximin Approved, Investigational Not Applicable 80621-81-4 6436173 46783403
17
Imidacloprid Vet_approved Not Applicable 105827-78-9 86418
18 Sodium-Glucose Transporter 2 Inhibitors Not Applicable
19 Antirheumatic Agents Not Applicable
20 Insulin, Globin Zinc Not Applicable
21 insulin Not Applicable
22 Hypoglycemic Agents Not Applicable
23 Interleukin 1 Receptor Antagonist Protein Not Applicable
24 Narcotics
25 Incretins Not Applicable
26
protease inhibitors Not Applicable
27 HIV Protease Inhibitors Not Applicable
28 Sitagliptin Phosphate Not Applicable
29 Dipeptidyl-Peptidase IV Inhibitors Not Applicable
30 Gastrointestinal Agents Not Applicable
31 Antidiarrheals Not Applicable
32 Glucagon-Like Peptide 1 Not Applicable
33 Anti-Inflammatory Agents, Non-Steroidal
34 Antipyretics
35 Anti-Infective Agents ,Not Applicable
36 Nutrients
37 Anti-Inflammatory Agents
38 Peripheral Nervous System Agents
39 Analgesics, Non-Narcotic
40 Analgesics
41 Antineoplastic Agents, Hormonal
42 Antibiotics, Antitubercular Not Applicable
43 Anti-Bacterial Agents Not Applicable

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
2 Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study. Recruiting NCT01794793 Phase 4 Pasireotide
3 Impact of the Techniques for Intrathoracic Esophagogastric Anastomosis on Outcome in Ivor-Lewis Oesophagectomy Unknown status NCT01242124 Phase 2, Phase 3
4 Comparison of Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy Recruiting NCT02595086 Phase 3
5 Randomized Controlled Trials Comparing Clinical Outcomes of 3D Versus 2D Laparoscopic Surgery for Gastric Cancer Active, not recruiting NCT02327481 Phase 3
6 Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
7 SOMATULINE Autogel 90 mg IN DUMPING SYNDROME Unknown status NCT01923649 Phase 2 Lanreotide 90 mg slow release formulation;Placebo
8 Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome Completed NCT01895296 Phase 2 Pasireotide;Placebo
9 Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome Completed NCT01637272 Phase 2 SOM230
10 Evaluation of Single Ascending Doses of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia Unknown status NCT02996812 Phase 1 Exendin (9-39)
11 Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients Unknown status NCT00873405 Not Applicable
12 A Study Comparing Billroth II With Roux-en-Y Reconstruction for Gastric Cancer Unknown status NCT01257711 Not Applicable
13 Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study Completed NCT03200782 Not Applicable Empagliflozin;Anakinra
14 Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide Completed NCT00802971 Not Applicable
15 Chronic Marginal Ulcers After Gastric Bypass Completed NCT01041079
16 Treatment of Diabetes After Gastric Bypass With Sitagliptin Completed NCT01512797 Not Applicable Sitagliptin phosphate
17 Omega Loop Versus Roux-en-Y Gastric Bypass Completed NCT02139813 Not Applicable
18 Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity Recruiting NCT02891330 Not Applicable
19 Dumping Syndrome After Operation of Esophageal Atresia Type III Recruiting NCT02525705 Not Applicable
20 Dumping Syndrome and Quality of Life After Vagus Nerve-preserving Distal Gastrectomy Recruiting NCT03880747
21 Comparisons Between Isoperistaltic and Antiperistaltic Gastrojejunostomy in Laparoscopic Distal Gastrectomy Recruiting NCT02837874 Not Applicable
22 Single-anastomosis Duodeno Ileal Bypass (SADI) Versus Roux-en-Y Gastric Bypass Recruiting NCT03610256 Not Applicable
23 Routine Post-Operative Supplemental Nutrition Active, not recruiting NCT02297607 Not Applicable
24 Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study Active, not recruiting NCT01778738 Not Applicable
25 Laparoscopic Versus Open Gastrectomy for Gastric Cancer Active, not recruiting NCT02248519 Not Applicable
26 Gastrectomy, Eating Behaviour and GLP-1 Enrolling by invitation NCT02971631 Not Applicable
27 Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery Enrolling by invitation NCT03734627 Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine
28 Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans Enrolling by invitation NCT02710370
29 Role and Mechanisms of Obesity Surgery - Physical Activity and Other Predictors of Hospital Stay, Recovery and Complications After Obesity Surgery Suspended NCT01998815
30 Metabolic Consequences of Gastrointestinal Surgery Terminated NCT02836353 Not Applicable Somatostatin;Rifaximin
31 Assessment of Gastric Emptying Speed in Patients Who Experience Diarrhea Following a Trigger Meal Withdrawn NCT01114113 Not Applicable pancelipase/placebo
32 Neujia Anastomosis for Treatment of Obesity and Type II Diabetes Withdrawn NCT03675074 Not Applicable

Search NIH Clinical Center for Dumping Syndrome

Cochrane evidence based reviews: dumping syndrome

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Genetic Tests for Dumping Syndrome

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Anatomical Context for Dumping Syndrome

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MalaCards organs/tissues related to Dumping Syndrome:

42
Small Intestine, Testes, Lung, Breast, Brain, Colon, Whole Blood
Sources

Publications for Dumping Syndrome

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Articles related to Dumping Syndrome:

(show top 50) (show all 901)
# Title Authors Year
1
Prevalence of Dumping Syndrome After Laparoscopic Sleeve Gastrectomy and Comparison with Laparoscopic Roux-en-Y Gastric Bypass. ( 30635813 )
2019
2
Detection of waste dumping locations in landfill using multi-temporal Landsat thermal images. ( 30632930 )
2019
3
Distribution of butyltins at dredged material dumping sites around the coast of China and the potential ecological risk. ( 30660299 )
2019
4
Age of both parents influences reproduction and egg dumping behavior in Drosophila melanogaster. ( 30753690 )
2019
5
Patient Dumping. ( 30801292 )
2019
6
Ocean Dumping of Containerized DDT Waste Was a Sloppy Process. ( 30829032 )
2019
7
A novel initiative to counteract illegal dumping in rural areas of Valladolid Province (Spain). ( 30854620 )
2019
8
Pulsed output generation in a diode-pumped cesium vapor laser using the cavity dumping technique. ( 30874638 )
2019
9
Safety and efficacy of pasireotide in dumping syndrome-results from a phase 2, multicentre study. ( 29696671 )
2018
10
Post-Fundoplication Dumping Syndrome: A Frequent "Rare" Complication. ( 29379815 )
2018
11
Transient severe distributive shock due to early dumping syndrome: a case report. ( 30208930 )
2018
12
Applications of peptide hormone ligands for the treatment of dumping and short bowel syndrome. ( 30273889 )
2018
13
The Effect of Dumping on Weight Loss in Conversion of Failed Restrictive Surgery: a Cross-Sectional Pilot Study. ( 28933032 )
2018
14
Assessing the risk of alcohol-induced dose dumping from sustained-release oral dosage forms: in vitro-in silico approach. ( 29043886 )
2018
15
Improving the monitoring of a dumping site in a dynamic environment. Example of the Octeville site (Bay of Seine, English Channel). ( 29055561 )
2018
16
Deep sea habitats in the chemical warfare dumping areas of the Baltic Sea. ( 29111251 )
2018
17
Identifying areas under potential risk of illegal construction and demolition waste dumping using GIS tools. ( 29402616 )
2018
18
Effects of open dumping of MSW on metal contamination of soil, plants, and earthworms in Ranchi, Jharkhand, India. ( 29442190 )
2018
19
Predictors of illegal dumping at charitable collection points. ( 29453014 )
2018
20
On the dumping ground genus Scotaena Klug, 1810 (Hymenoptera: Tiphiidae: Thynninae): Phylogeny, taxonomy and geographic distribution. ( 29690290 )
2018
21
Impact of dredged-material disposal on soft-bottom communities in a recurrent marine dumping area near to Guadalquivir estuary, Spain. ( 29773315 )
2018
22
Long-term self-reported symptom prevalence of early and late dumping in a patient population after sleeve gastrectomy, primary, and revisional gastric bypass surgery. ( 29858129 )
2018
23
Europe's biggest research fund cracks down on 'ethics dumping'. ( 29970912 )
2018
24
946  nm Nd:YAG laser with cavity dumping. ( 30004529 )
2018
25
Mercury contamination in the sludge of drinking water treatment plants dumping into a reservoir in Rio de Janeiro, Brazil. ( 30099710 )
2018
26
Phytoremediation of waste dumping site soil and landfill leachate by using cattail (Typha latifolia). ( 30198835 )
2018
27
Dumping to the abyss: single-use marine litter invading bathyal plains of the Sardinian margin (Tyrrhenian Sea). ( 30301106 )
2018
28
Patient Dumping Is Still a Problem. ( 30358587 )
2018
29
Prevalence and pathophysiology of early dumping in patients after primary Roux-en-Y gastric bypass during a mixed-meal tolerance test. ( 30446401 )
2018
30
Prevalence and pathophysiology of early dumping in patients after primary Roux-en-Y gastric bypass during a mixed-meal tolerance test. ( 30503167 )
2018
31
Insight into occurrence, profile and spatial distribution of organochlorine pesticides in soils of solid waste dumping sites of Pakistan: Influence of soil properties and implications for environmental fate. ( 30529619 )
2018
32
Nonmotile Single-Cell Migration as a Random Walk in Nonuniformity: The "Extreme Dumping Limit" for Cell-to-Cell Communications. ( 30595832 )
2018
33
Severe Dumping Syndrome in a 6-year-old Girl with Congenital Microgastria Treated by Hunt-Lawrence Pouch. ( 28361011 )
2017
34
Effectiveness of sitagliptin in a patient with late dumping syndrome after total gastrectomy. ( 29208515 )
2017
35
A case report: Liraglutide as a novel treatment option in late dumping syndrome. ( 28328816 )
2017
36
Late Dumping Syndrome in a 17-Year-Old Female With Charge Syndrome. ( 29205658 )
2017
37
Pregnancy and Dumping Syndrome post-bariatric surgery: a case report. ( 28473681 )
2017
38
Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management. ( 27749997 )
2017
39
The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life. ( 28624531 )
2017
40
Incretin Kinetics Before and After Miglitol in Japanese Patients With Late Dumping Syndrome. ( 28912925 )
2017
41
Pasireotide and octreotide in the treatment of severe late dumping syndrome. ( 29026555 )
2017
42
Experience with FreeStyle Libre Flash glucose monitoring system in management of refractory dumping syndrome in pregnancy shortly after bariatric surgery. ( 29302329 )
2017
43
Dumping Syndrome ( 29261889 )
2017
44
Dumping the information bucket: A qualitative study of clinicians caring for patients with early stage non-small cell lung cancer. ( 28034611 )
2017
45
High peak power cavity dumping semiconductor lasers. ( 28059191 )
2017
46
Traffic accident or dumping? - Striking results of a traffic accident reconstruction. ( 28081791 )
2017
47
Individual Physician Penalties Resulting From Violation of Emergency Medical Treatment and Labor Act: A Review of Office of the Inspector General Patient Dumping Settlements, 2002-2015. ( 28109011 )
2017
48
Before-After analysis of the trophic network of an experimental dumping site in the eastern part of the Bay of Seine (English Channel). ( 28233526 )
2017
49
Can soda ash dumping grounds provide replacement habitats for digger wasps (Hymenoptera, Apoidea, Spheciformes)? ( 28423033 )
2017
50
Dumping symptoms is triggered by fat as well as carbohydrates in patients operated with Roux-en-Y gastric bypass. ( 28433465 )
2017
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Variations for Dumping Syndrome

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Expression for Dumping Syndrome

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Search GEO for disease gene expression data for Dumping Syndrome.
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Pathways for Dumping Syndrome

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Pathways related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 67
Show member pathways
 13.4 GCG GIP INS NTS PYY SCT
2
Aldosterone synthesis and secretion 38
Show member pathways
 12.47 GCG GIP INS
3
Peptide ligand-binding receptors 67
Show member pathways
 12.38 GCG GIP NTS PYY SCT SST
4
Presynaptic function of Kainate receptors 67
Show member pathways
 11.9 GCG GIP SCT
5
Peptide hormone metabolism 67
Show member pathways
 11.69 GCG GIP INS
6
G alpha (s) signalling events 67
11.3 GCG GIP SCT
7
Incretin synthesis, secretion, and inactivation 67
Show member pathways
 11.15 GCG GIP
8
FOXA1 transcription factor network 1
Show member pathways
 11.03 GCG INS
Sources

GO Terms for Dumping Syndrome

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Cellular components related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 GCG GIP INS
2 extracellular space GO:0005615 9.43 GCG GIP INS PYY SCT SST
3 secretory granule lumen GO:0034774 9.33 GCG GIP INS
4 transport vesicle GO:0030133 9.32 INS NTS
5 extracellular region GO:0005576 9.17 GCG GIP INS NTS PYY SCT

Biological processes related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.5 GCG GIP INS NTS PYY SCT
2 regulation of insulin secretion GO:0050796 9.4 GCG GIP
3 response to amino acid GO:0043200 9.37 GIP SST
4 feeding behavior GO:0007631 9.32 GCG PYY
5 positive regulation of cAMP-mediated signaling GO:0043950 9.26 GIP SCT
6 regulation of signaling receptor activity GO:0010469 9.17 GCG GIP INS NTS PYY SCT
7 response to acidic pH GO:0010447 9.16 GIP SST

Molecular functions related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.16 PYY SCT
2 hormone activity GO:0005179 9.1 GCG GIP INS PYY SCT SST
3 neuropeptide hormone activity GO:0005184 8.96 NTS PYY
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Sources for Dumping Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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