Dumping Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DMP001 MIFTS: 44	Dumping Syndrome Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Dumping Syndrome

MalaCards integrated aliases for Dumping Syndrome:

Name: Dumping Syndrome ¹² ⁵⁵ ⁴⁴ ¹⁵ ¹⁷ ⁷²

Dumping ⁵⁵ ⁷²

Postgastrectomy Syndromes ⁷²

Dumping Syndrome ¹²

Jejunal Syndrome ¹²

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Other diseases of the digestive system

Postprocedural disorders of digestive system, not elsewhere classified

Postgastric surgery syndromes

External Ids:

Disease Ontology ¹² DOID:14495

MeSH ⁴⁴ D004377

NCIt ⁵⁰ C2994

SNOMED-CT ⁶⁸ 80193009

ICD10 ³³ K91.1

EFO ¹⁷ EFO_1001307

UMLS ⁷² C0013288 C0032763 C0221542

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Summaries for Dumping Syndrome

MalaCards based summary : Dumping Syndrome, also known as dumping, is related to hyperinsulinemic hypoglycemia and gastroesophageal reflux, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Dumping Syndrome is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and Aldosterone synthesis and secretion. The drugs lanreotide and Pasireotide have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and brain.

Wikipedia : ⁷⁵ Dumping syndrome occurs when food, especially sugar, moves too quickly from the stomach to the... more...

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Related Diseases for Dumping Syndrome

Diseases related to Dumping Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)

#	Related Disease	Score	Top Affiliating Genes
1	hyperinsulinemic hypoglycemia	30.5	SST INS
2	gastroesophageal reflux	30.3	PYY NTS GCG
3	duodenal ulcer	30.3	SST SCT INS
4	hyperinsulinism	30.0	SST INS
5	diabetes mellitus, insulin-dependent	29.5	SST INS GCG
6	constipation	29.4	SST PYY NTS
7	glucose intolerance	29.3	INS GCG
8	insulinoma	29.2	SST SCT INS GCG
9	hyperglycemia	29.1	SST INS GIP GCG
10	duodenogastric reflux	28.9	SST SCT PYY NTS
11	short bowel syndrome	28.9	SST PYY NTS GCG
12	gastrointestinal system disease	28.0	SST SCT PYY INS GCG
13	diabetes mellitus, noninsulin-dependent	27.6	SST PYY INS GIP GCG
14	hypoglycemia	10.8
15	peptic ulcer disease	10.6
16	diarrhea	10.5
17	type 1 diabetes mellitus 15	10.3	INS GCG
18	hyperinsulinemic hypoglycemia, familial, 7	10.3	INS GCG
19	maturity-onset diabetes of the young, type 9	10.3	INS GCG
20	leptin deficiency or dysfunction	10.3
21	hirata disease	10.3	INS GCG
22	gastrointestinal ulceration, recurrent, with dysfunctional platelets	10.3
23	acute insulin response	10.3	INS GCG
24	pancreatoblastoma	10.3	SST NTS
25	prediabetes syndrome	10.2	INS GCG
26	space motion sickness	10.2	SCT NTS
27	duodenal somatostatinoma	10.2	SST INS
28	somatostatinoma	10.2	SST INS
29	pancreatic endocrine carcinoma	10.2	SST INS
30	afferent loop syndrome	10.2
31	hyperpituitarism	10.2	SST INS
32	hyperproinsulinemia	10.2	SCT INS
33	functional gastric disease	10.1	SST INS
34	glucagonoma	10.1	SST SCT
35	islet cell tumor	10.1	SST INS
36	iron metabolism disease	10.1
37	47,xyy	10.1
38	dysphagia	10.1
39	angiodysplasia	10.1	SST SCT
40	pituitary-dependent cushing's disease	10.1	SST INS
41	maturity-onset diabetes of the young, type 7	10.1	SCT INS
42	duodenal gastrinoma	10.1	SST SCT
43	endocrine organ benign neoplasm	10.1	SST INS
44	steatorrhea	10.1	SST SCT
45	thyroid gland disease	10.1	SST INS
46	pituitary gland disease	10.1	SST INS
47	cell type benign neoplasm	10.0	SST INS
48	ocular motor apraxia	10.0
49	arts syndrome	10.0
50	body mass index quantitative trait locus 1	10.0

Graphical network of the top 20 diseases related to Dumping Syndrome:

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Symptoms & Phenotypes for Dumping Syndrome

UMLS symptoms related to Dumping Syndrome:

constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery

Sources

Drugs & Therapeutics for Dumping Syndrome

Drugs for Dumping Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

lanreotide

Approved

Phase 4

108736-35-2

Pasireotide

Approved

Phase 4

396091-73-9

9941444

Empagliflozin

Approved

Phase 4

864070-44-0

Dopamine

Approved

Phase 4

51-61-6, 62-31-7

681

Cabergoline

Approved

Phase 4

81409-90-7

54746

Orlistat

Approved, Investigational

Phase 4

96829-58-2

3034010

Linagliptin

Approved

Phase 4

668270-12-0

10096344

Liraglutide

Approved

Phase 4

204656-20-2

44147092

Canagliflozin

Approved

Phase 4

842133-18-0

Lactitol

Investigational

Phase 4

585-86-4, 585-88-6

493591

Angiopeptin

Phase 4

Hormones

Phase 4

Hormone Antagonists

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4

Incretins

Phase 4

Sodium-Glucose Transporter 2 Inhibitors

Phase 4

Hypoglycemic Agents

Phase 4

Neurotransmitter Agents

Phase 4

Dopamine Agents

Phase 4

Antiparkinson Agents

Phase 4

Dopamine agonists

Phase 4

Anti-Obesity Agents

Phase 4

HIV Protease Inhibitors

Phase 4

Sitagliptin Phosphate

Phase 4

Lipid Regulating Agents

Phase 4

protease inhibitors

Phase 4

Dipeptidyl-Peptidase IV Inhibitors

Phase 4

Exenatide

Approved, Investigational

Phase 1

141758-74-9

15991534

Guaifenesin

Approved, Investigational, Vet_approved

Phase 1

93-14-1

3516

Hydrocodone

Approved, Illicit, Investigational

Phase 1

125-29-1

5284569

Glucagon

Approved

Phase 1

16941-32-5

Analgesics

Phase 1

Peripheral Nervous System Agents

Phase 1

Narcotics

Phase 1

Chlorpheniramine, phenylpropanolamine drug combination

Phase 1

Respiratory System Agents

Phase 1

Central Nervous System Depressants

Phase 1

Analgesics, Opioid

Phase 1

Antitussive Agents

Phase 1

Glimepiride

Approved

93479-97-1

3476

Metformin

Approved

657-24-9

4091 14219

Loperamide

Approved

53179-11-6

3955

Somatostatin

Approved, Investigational

38916-34-6, 51110-01-1

53481605

Octreotide

Approved, Investigational

83150-76-9

383414 6400441

Acetaminophen

Approved

103-90-2

1983

Sulfasalazine

Approved

599-79-1

5359476 5353980

Methylene blue

Approved, Investigational

61-73-4

Rifaximin

Approved, Investigational

80621-81-4

46783403 6436173

Trichostatin A

Vitamins

Interventional clinical trials:

(show all 50)

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of the Dumping Syndrome With Lanreotide Autogel®	Unknown status	NCT00543179	Phase 4	Somatuline (Lanreotide Autogel®)
2	An Open Label, Multi-center Pasireotide Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Pasireotide Study and Are Judged by the Investigator to Benefit From Continued Pasireotide Treatment	Recruiting	NCT01794793	Phase 4	Pasireotide;Cabergoline;Pasireotide
3	Roux-en-Y Gastric Bypass for BMI 27-32 Type 2 Diabetes vs Best Medical Treatment	Recruiting	NCT02041234	Phase 4	Incretin analogues;Xenical;SGLT2 inhibitors;DPP-4 Inhibitors
4	Multicenter Randomized Controlled Trial Comparing Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy for the Middle Third Early Gastric Cancer (KLASS-04)	Recruiting	NCT02595086	Phase 3
5	Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass	Not yet recruiting	NCT03984370	Phase 3	ZP4207
6	Hyperbaric Oxygenation (HBO) in Chronic Diabetic Leg Ulcer.	Not yet recruiting	NCT02042339	Phase 3	Hyperbaric oxygen
7	SOMATULINE Autogel 90 mg IN DUMPING SYNDROME	Unknown status	NCT01923649	Phase 2	Lanreotide 90 mg slow release formulation;Placebo
8	A Multi-center, Intra-patient Dose Escalation Phase II Study to Evaluate the Preliminary Efficacy, Safety and Pharmacokinetics of Pasireotide (SOM230) Subcutaneous (s.c.) Followed by Pasireotide LAR in Patients With Dumping Syndrome	Completed	NCT01637272	Phase 2	SOM230
9	Exploratory Randomized, Placebo-controlled Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome	Completed	NCT01895296	Phase 2	Pasireotide;Placebo
10	A Pilot Phase II Study of Hyperbaric Oxygen for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (HOPPS)	Completed	NCT01306968	Phase 2	hyperbaric oxygen
11	Subcutaneous Injection of Exendin (9-39) in Subjects With Hyperinsulinemic Hypoglycemia Post-Bariatric Surgery	Unknown status	NCT02996812	Phase 1	Exendin (9-39)
12	Visualizing Beta Cells in Patients With Hyperinsulinemic Hypoglycemia After Bariatric Surgery	Unknown status	NCT03182192	Phase 1
13	A Phase I, Double-Blind, Placebo-Controlled, Randomized, 3-Period, Safety and Pharmacokinetic Study of 13C-uracil in a Semi-solid Meal at Single Oral Doses of 50, 100, and 200 mg in Healthy Volunteers	Completed	NCT01074710	Phase 1	[2-13C] uracil;[2-13C] uracil, placebo
14	A Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Assess the Abuse Potential of the Hydrocodone Bitartrate Extended-Release Tablet in Healthy, Nondependent, Recreational Opioid Users	Completed	NCT01596673	Phase 1	45-mg hydrocodone bitartrate extended-release tablet (crushed or intact);Placebo
15	Treatment Plan for an Individual Patient With Pasireotide for Hyperinsulinemic Hypoglycemia	Recruiting	NCT03103009	Phase 1	Pasireotide
16	Gastric Emptying: in Vivo Studies in Healthy Volunteers (Using Scrambled Egg and Porridge) to Determine Reliable Normal Ranges	Unknown status	NCT02994472
17	A Prospective Randomised Study Comparing Billroth II With Roux-en-Y Reconstruction After Radical Distal Subtotal Gastrectomy for Gastric Cancer	Unknown status	NCT01257711
18	Incidence of Medical and Nutritional Complications After Bariatric Surgery, Especially Focusing on Assessment and Treatment of Severe Hypoglycemia	Unknown status	NCT01865760		Octreotide;Synthetic Exendin 9-39
19	Gastric Artery Embolization Trial for Lessening Appetite Nonsurgically (GET LEAN)	Unknown status	NCT02248688
20	Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients: a Prospective Controlled Trial.	Unknown status	NCT00873405
21	Prevalence of Medical and Nutritional Complications After Bariatric Surgery (Gastric Bypass) Based on a Clinical Trial	Unknown status	NCT01930838
22	Frequency of Occurrence of Dumping Syndrome After Operation of Esophageal Atresia Type III	Completed	NCT02525705
23	Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study	Completed	NCT03200782		Empagliflozin;Anakinra
24	Oral Glucosestimulation After Gastric Bypass Surgery	Completed	NCT01851616
25	Prevalence of Idiopathic Reactive Hypoglycaemia and Impact of Fructo-Oligosaccharide Supplementation on Blood Glucose Variability	Completed	NCT00802971
26	Postoperative Dietary Counseling After Bariatric Surgery	Completed	NCT00125073
27	Role of Glucagon-Like Peptide-1 in Postprandial Hypoglycemia After Nissen Fundoplication: Studies With the GLP-1 Receptor Antagonist Exendin-(9-39)	Completed	NCT01162499		Exendin-(9-39)
28	Meal Stimulating After Roux-en Y Gastric Bypass	Completed	NCT00915980
29	Prevalence of Medical and Nutritional Complications After Bariatric Surgery (Gastric Bypass) Based on a Questionnaire Survey	Completed	NCT01930851
30	The Effect of Food on the Pharmacokinetics of Metformin Given Either as Metformin Hydrochloride SR 1000mg Tablet or as a Fixed Dose Combination of Metformin Hydrochloride SR 1000mg/Glimepiride 2mg Tablet in Healthy Indian Volunteers.	Completed	NCT01561976		Metformin hydrochloride prolonged release;metformin hydrochloride prolonged release;Metformin hydrochloride sustained release/Glimepiride
31	The Effect of Fat Supplementation on the Appearance of Symptoms Associated With Dumping Syndrome in Patients Undergone Bariatric Surgery	Recruiting	NCT04028193
32	Assessing the Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity With the Risk of Occurrence of Dumping Syndrome After Gastric Bypass.	Recruiting	NCT02891330
33	Incidence of Dumping Syndrome After Laparoscopic Vagus Nerve-preserving Distal Gastrectomy for Early Gastric Cancer	Recruiting	NCT03880747
34	Comparisons Between Isoperistaltic and Antiperistaltic Gastrojejunostomy in Laparoscopic Distal Gastrectomy, Randomized Prospective Pilot Study	Recruiting	NCT02837874
35	Functional Outcome Following Ivor-Lewis Oesophagectomy	Recruiting	NCT03658837
36	Cohorte Obésité Bichat LOuis Mourier	Recruiting	NCT03538210
37	European Dumping Study: Validation of a Diagnostic Tool for Postprandial Hypoglycaemia in Patients After Roux en Y Gastric Bypass Surgery	Recruiting	NCT03406312
38	Mayo Clinic Conduit Report Card Questionnaires	Recruiting	NCT02530983
39	A 90 Day, Phase 4, Open Labeled Exploratory Study of RELiZORB to Evaluate Safety, Tolerability, and Nutrient Absorption in Children With Short Bowel Syndrome Who Are Dependent on Parenteral Nutrition	Recruiting	NCT03530852
40	Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes	Recruiting	NCT04001842
41	ENSURE: European iNvestigation of SUrveillance After Resection for Esophageal Cancer	Active, not recruiting	NCT03461341
42	An Intervention Model for the Prevention of Infertility in Healthy Young Men Living in Highly Polluted Areas	Active, not recruiting	NCT04012385
43	The Effect of Glucagon Like Peptide-1 (GLP-1) on Glycaemic Profile and Eating Behaviour Following Gastrectomy	Enrolling by invitation	NCT02971631
44	Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery	Enrolling by invitation	NCT03734627		Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine
45	Gastric Cancer Sentinel Lymph Node Sampling: Refining Patient Selection for Organ Sparing Resection of Early Gastric Cancer in a North American Context	Enrolling by invitation	NCT03049345		Radioactive Tracers;Methylene Blue 20 MG/ML
46	Applying Nutrient Drink Test in Understanding Pathophysiology of Cyclic Vomiting Syndrome	Enrolling by invitation	NCT03470181
47	Role and Mechanisms of Obesity Surgery - Physical Activity and Other Predictors of Hospital Stay, Recovery and Complications After Obesity Surgery	Suspended	NCT01998815
48	The Metabolic Consequences of Gastrointestinal Surgery	Terminated	NCT02836353		Somatostatin;Rifaximin
49	Evaluation of an Intervention (Consisting of an Electronic Reminder Device, Pillboxes, and Monthly Telephone Calls) on Adherence to Highly Active Antiretroviral Therapy (HAART) in HIV Infected Adults	Terminated	NCT00203853
50	Pilot Study: Assessment of Gastric and Intestinal Motility Following a Trigger Meal in Patients With Post Prandial Diarrhea	Withdrawn	NCT01114113		pancelipase/placebo

Search NIH Clinical Center for Dumping Syndrome

Cochrane evidence based reviews: dumping syndrome

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Genetic Tests for Dumping Syndrome

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Anatomical Context for Dumping Syndrome

MalaCards organs/tissues related to Dumping Syndrome:

⁴¹

Small Intestine, Testes, Brain, Colon, Liver, Lung, Lymph Node

Sources

Publications for Dumping Syndrome

Articles related to Dumping Syndrome:

(show top 50) (show all 3519)

#	Title	Authors	PMID	Year
1	Pathophysiology, diagnosis and management of postoperative dumping syndrome. ⁹ ³⁸	Tack J...Bisschops R	19724252	2009
2	Efficacy of the long-acting repeatable formulation of the somatostatin analogue octreotide in postoperative dumping. ⁹ ³⁸	Arts J...Tack J	19264574	2009
3	A possible role of GLP-1 in the pathophysiology of early dumping syndrome. ⁹ ³⁸	Yamamoto H...Tani T	16416173	2005
4	Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome. ⁹ ³⁸	Gebhard B...Miholic J	11575444	2001
5	Gastrointestinal hormone in dumping syndrome and reflux esophagitis after gastric surgery. ⁹ ³⁸	Yamashita Y...Adrian TE	9403815	1997
6	The dumping syndrome. Current insights into pathophysiology, diagnosis and treatment. ⁹ ³⁸	Vecht J...Lamers CB	9200302	1997
7	[Neurohumoral regulation of gastric secretion in postvagotomy syndromes]. ⁹ ³⁸	Khalmuratova RA...Arutiunova MV	7933883	1994
8	[Postgastrectomy dumping treated with octreotide (Sandostatin)]. ⁹ ³⁸	Moller TD...Carlsen CU	8317033	1993
9	The effect of somatostatin in dumping syndrome after gastric surgery. ⁹ ³⁸	Tulassay Z...Tamas G	8103615	1993
10	Atrial natriuretic peptide in dumping syndrome. ⁹ ³⁸	Tulassay Z...Rascher W	8513987	1993
11	Potential indications for octreotide in gastroenterology: summary of workshop. ⁹ ³⁸	Burroughs AK...Malagelada R	8359570	1993
12	Dumping syndrome and the regulation of peptide YY with verapamil. ⁹ ³⁸	Chandos B	1415124	1992
13	Decreased activity of atrial natriuretic peptide in dumping syndrome after gastric surgery. ⁹ ³⁸	Tulassay Z...Rascher W	1830840	1991
14	[The effect of somatostatin in dumping syndrome]. ⁹ ³⁸	Tulassay Z...Tamas G	1978748	1990
15	[Atrial natriuretic peptide in dumping syndrome]. ⁹ ³⁸	Tulassay Z...Wolfgang R	2146582	1990
16	Giving advice to callers with mental illness: adaptation among telenurses at Swedish Healthcare Direct. ³⁸	Bjorkman A...Salzmann-Erikson M	31242817	2019
17	Does pregnancy interval after laparoscopic sleeve gastrectomy affect maternal and perinatal outcomes? ³⁸	Basbug A...Goynumer G	29712482	2019
18	Healthcare waste management in Asian developing countries: A mini review. ³⁸	Khan BA...Ahmed H	31266407	2019
19	Environmental, health, wellbeing, social and equity effects of urban green space interventions: A meta-narrative evidence synthesis. ³⁸	Hunter RF...Braubach M	31228780	2019
20	Environmental and economic feasibility of an integrated community composting plant and organic farm in Malaysia. ³⁸	Lim LY...Klemes JJ	31153031	2019
21	[Long-term management after bariatric surgery]. ³⁸	De Flines J...Paquot N	31436062	2019
22	The role of solid waste composting in mitigating climate change in Jordan. ³⁸	Abu Qdais H...Nassour A	31218931	2019
23	Silk Fibroin as a Novel Alcohol-Resistant Excipient for Sustained-Release Tablet Formulation. ³⁸	Kozak J...Lamprecht A	31399868	2019
24	Quorum sensing inhibition as a promising method to control biofilm growth in metalworking fluids. ³⁸	Ozcan SS...Foreman CM	31020467	2019
25	Review on Indian Municipal Solid Waste Management practices for reduction of environmental impacts to achieve sustainable development goals. ³⁸	Pujara Y...Govani J	31319199	2019
26	Saudi Arabia-China-Pakistan Economic Corridor: intergovernmental green initiatives. ³⁸	Naz A...Abro MMQ	31267397	2019
27	Using GIS and optimization to manage construction and demolition waste: The case of abandoned quarries in Lebanon. ³⁸	AlZaghrini N...Srour I	31351599	2019
28	Characterizing the paper industry sludge for environmentally-safe disposal. ³⁸	de Azevedo ARG...Marvila MT	31351628	2019
29	Distribution and health risk assessment of arsenic and selected heavy metals in Groundwater of Chandigarh, India. ³⁸	Ravindra K...Mor S	31048111	2019
30	Engineering a bioluminescent bioreporter from an environmentally sourced mercury-resistant Enterobacter cloacae strain for the detection of bioavailable mercury. ³⁸	Din G...Shah AA	31336395	2019
31	A chronic toxicity study of diphenylarsinic acid in the drinking water of C57BL/6J mice for 52 weeks. ³⁸	Yamaguchi T...Wanibuchi H	31404369	2019
32	Gastroparesis and Dumping Syndrome: Current Concepts and Management. ³⁸	Vavricka SR...Greuter T	31362413	2019
33	The effect of ventricular volume increase in the amplitude of intracranial pressure. ³⁸	Apura J...Sequeira A	30931613	2019
34	Diazoxide for the Treatment of Hypoglycemia Resulting From Dumping Syndrome in a Child. ³⁸	Mejia-Otero JD...Patni N	31286099	2019
35	Gastrostomy Placement and Management in Children: A Single-Center Experience. ³⁸	Di Leo G...Codrich D	31295800	2019
36	Pregnancy after 24 Postoperative Months of Roux-En-Y Gastric Bypass Presents Risk of Pregnancy Complications Similar to Pregnancy within the First Postoperative Year. ³⁸	Cruz S...Ramalho A	31288227	2019
37	Sea-dumped ammunition as a possible source of mercury to the Baltic Sea sediments. ³⁸	Beldowski J...Pempkowiak J	31005838	2019
38	A School of Nursing's Response to Hurricane Harvey. ³⁸	Robinson R...Wenner L	31335491	2019
39	Crohn's Disease of the Esophagus, Duodenum, and Stomach. ³⁸	Schwartzberg DM...Grucela AL	31275069	2019
40	A Real-World, Insurance-Based Algorithm Using the Two-Fold Running Suture Technique for Transoral Outlet Reduction for Weight Regain and Dumping Syndrome After Roux-En-Y Gastric Bypass. ³⁸	Fayad L...Kumbhari V	30937874	2019
41	Endoscopic Gastrojejunal Revision (Transoral Outlet Reduction) for Persistent Hypoglycemia After Gastric Bypass. ³⁸	Conaty EA...Ujiki MB	31338736	2019
42	Comparison of the dietary intake amongst women in the late postoperative period after Roux-en-Y gastric bypass with the bariatric food pyramidof dietary intake with reference values among women in late postoperative of y-en-roux gastric bypass. ³⁸	Reichmann MTF...Radominski RB	30985187	2019
43	Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A. ³⁸	Cil O...Verkman AS	31299174	2019
44	Environmental Impact of Heavy Metals from Poultry Waste Discharged into the Olosuru Stream, Ikire, Southwestern Nigeria. ³⁸	Oyewale AT...Aduwo AI	31259083	2019
45	The Hyperbaric Protective Tube: A housing for a left ventricular assist device (LVAD) in a multiplace hyperbaric chamber. ³⁸	Kot J...Lenkiewicz E	31177520	2019
46	Vermicomposting process for treating animal slurry in Latin American rural areas. ³⁸	Nova Pinedo ML...Torretta V	30950327	2019
47	Extreme spatial variation of Sr, Nd and Pb isotopic signatures and 48 element mass fractions in surface sediment of the Elbe River Estuary - Suitable tracers for processes in dynamic environments? ³⁸	Reese A...Irrgeher J	30856563	2019
48	Trends of electronic waste pollution and its impact on the global environment and ecosystem. ³⁸	Akram R...Nasim W	31025281	2019
49	Organochlorine pesticides air monitoring near a historical lindane production site in Spain. ³⁸	Navarro I...Martinez MA	31018415	2019
50	Drivers of legal and illegal solid waste disposal in the Global South - The case of households in Yaoundé (Cameroon). ³⁸	Sotamenou J...Rousseau S	30953985	2019

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Genes for Dumping Syndrome

Genes related to Dumping Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SST	Somatostatin	Protein Coding	31.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8103615 1978748 19724252 (more) 8359570 8317033 19264574 7933883
2	NTS	Neurotensin	Protein Coding	29.79	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9403815
3	PYY	Peptide YY	Protein Coding	26.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1415124
4	GCG	Glucagon	Protein Coding	25.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16416173 9200302 11575444
5	INS	Insulin	Protein Coding	23.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	GIP	Gastric Inhibitory Polypeptide	Protein Coding	22.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	SCT	Secretin	Protein Coding	20.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Dumping Syndrome

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Expression for Dumping Syndrome

Search GEO for disease gene expression data for Dumping Syndrome.

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Pathways for Dumping Syndrome

Pathways related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁶ Show member pathways GPCR downstream signaling ⁶⁶ Signal Transduction ⁶⁶	13.4	SST SCT PYY NTS INS GIP
2	Aldosterone synthesis and secretion ³⁷ Show member pathways Ca2+ activated K+ channels ⁶⁶ Cortisol synthesis and secretion ³⁷ Cushing syndrome ³⁷ Insulin secretion ³⁷ Melanogenesis ³⁷ Thyroid hormone synthesis ³⁷	12.38	INS GIP GCG
3	Peptide ligand-binding receptors ⁶⁶ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁶ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁶ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁶ G alpha (i) signalling events ⁶⁶ GPCR ligand binding ⁶⁶ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁷ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁶ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁶ Vasopressin-like receptors ⁶⁶	12.38	SST SCT PYY NTS GIP GCG
4	Presynaptic function of Kainate receptors ⁶⁶ Show member pathways Activation of Ca-permeable Kainate Receptor ⁶⁶ Activation of Kainate Receptors upon glutamate binding ⁶⁶ Activation of Na-permeable Kainate Receptors ⁶⁶ Calcitonin-like ligand receptors ⁶⁶ Class B/2 (Secretin family receptors) ⁶⁶ G beta-gamma signalling through PLC beta ⁶⁶ Glucagon-type ligand receptors ⁶⁶ G-Protein Signaling through Tubby Protein ⁶⁴ Ionotropic activity of Kainate Receptors ⁶⁶	11.9	SCT GIP GCG
5	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Insulin processing ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶	11.69	INS GIP GCG
6	G alpha (s) signalling events ⁶⁶	11.3	SCT GIP GCG
7	Incretin synthesis, secretion, and inactivation ⁶⁶ Show member pathways Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ⁶⁶ Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) ⁶⁶	11.15	GIP GCG
8	FOXA1 transcription factor network ¹ Show member pathways FOXA transcription factor networks ¹	11.03	INS GCG

Sources

GO Terms for Dumping Syndrome

Cellular components related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.43	INS GIP GCG
2	extracellular space	GO:0005615	9.43	SST SCT PYY INS GIP GCG
3	secretory granule lumen	GO:0034774	9.33	INS GIP GCG
4	transport vesicle	GO:0030133	9.32	NTS INS
5	extracellular region	GO:0005576	9.17	SST SCT PYY NTS INS GIP

Biological processes related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of insulin secretion	GO:0050796	9.37	GIP GCG
2	response to amino acid	GO:0043200	9.32	SST GIP
3	feeding behavior	GO:0007631	9.26	PYY GCG
4	G protein-coupled receptor signaling pathway	GO:0007186	9.17	SST SCT PYY NTS INS GIP
5	positive regulation of cAMP-mediated signaling	GO:0043950	9.16	SCT GIP
6	response to acidic pH	GO:0010447	8.96	SST GIP

Molecular functions related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor binding	GO:0001664	9.16	SCT PYY
2	hormone activity	GO:0005179	9.1	SST SCT PYY INS GIP GCG
3	neuropeptide hormone activity	GO:0005184	8.96	PYY NTS

Sources

Sources for Dumping Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia