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MCID: DMP001
MIFTS: 44

Dumping Syndrome

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Dumping Syndrome

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MalaCards integrated aliases for Dumping Syndrome:

Name: Dumping Syndrome 12 54 43 15 17 71
Dumping 54 71
Postgastrectomy Syndromes 71
Dumping Syndrome 12
Jejunal Syndrome 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:14495
MeSH 43 D004377
NCIt 49 C2994
SNOMED-CT 67 80193009
ICD10 32 K91.1
UMLS 71 C0013288 C0032763 C0221542
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Summaries for Dumping Syndrome

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MalaCards based summary : Dumping Syndrome, also known as dumping, is related to hypoglycemia and hyperinsulinemic hypoglycemia, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Dumping Syndrome is GCG (Glucagon), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs lanreotide and Pasireotide have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and colon.

Wikipedia : 74 Dumping syndrome occurs when food, especially sugar, moves too quickly from the stomach to the... more...

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Related Diseases for Dumping Syndrome

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Diseases related to Dumping Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 hypoglycemia 30.8 SST INS GHRL GCG
2 hyperinsulinemic hypoglycemia 30.5 SST INS GCG
3 peptic ulcer disease 30.1 SST SCT GHRL GAST
4 hyperinsulinism 30.1 SST INS GHRL GCG
5 bile reflux 30.0 GAST CCK
6 pyloric stenosis 29.9 SST MLN GAST
7 biliary dyskinesia 29.7 SST SCT CCK
8 glucose intolerance 29.6 INS GHRL GCG
9 insulinoma 29.5 SST SCT INS GCG GAST
10 duodenal ulcer 29.4 SST SCT MLN INS GAST CCK
11 diabetes mellitus, insulin-dependent 29.4 SST SCT INS GCG
12 gastritis 29.2 SST SCT GHRL GAST
13 leptin deficiency or dysfunction 29.2 PYY INS GIP GHRL GCG CCK
14 gastroesophageal reflux 28.9 PYY NTS MLN GHRL GCG GAST
15 irritable bowel syndrome 28.8 SST PYY MLN GHRL CCK
16 hyperglycemia 28.8 SST PYY INS GIP GHRL GCG
17 gastrointestinal system disease 28.8 MLN GHRL GCG GAST CCK
18 gastroparesis 28.6 SST MLN GIP GHRL GAST CCK
19 constipation 28.5 SST PYY NTS MLN GCG GAST
20 duodenogastric reflux 28.4 SST SCT PYY NTS MLN GAST
21 short bowel syndrome 28.1 SST PYY NTS GHRL GCG GAST
22 diarrhea 27.9 SST SI SCT PYY MLN MGAM
23 diabetes mellitus, noninsulin-dependent 25.7 SST SI SCT PYY NTS MGAM
24 erythematosquamous dermatosis 10.4 INS GCG
25 hirata disease 10.4 INS GCG
26 cervical large cell neuroendocrine carcinoma 10.4 SST GCG
27 hypoglycemic coma 10.4 INS GCG
28 transient refractive change 10.4 SST INS
29 adenosquamous bile duct carcinoma 10.4 GIP GCG
30 squamous cell bile duct carcinoma 10.4 GIP GCG
31 acute insulin response 10.4 INS GCG
32 pituitary infarct 10.4 SST INS
33 duodenal somatostatinoma 10.4 SST INS
34 functional colonic disease 10.4 SST MLN
35 acidophil adenoma 10.4 SST INS
36 alzheimer disease 6 10.3 INS GCG
37 colonic pseudo-obstruction 10.3 SST MLN
38 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.3
39 pituitary apoplexy 10.3 SST INS
40 rectum neuroendocrine neoplasm 10.3 SST GAST
41 gastrointestinal neuroendocrine benign tumor 10.3 SST GAST
42 non-functioning pancreatic endocrine tumor 10.3 SST GAST
43 gastric neuroendocrine neoplasm 10.3 SST GAST
44 hyperpituitarism 10.3 SST INS
45 pancreatoblastoma 10.3 SST NTS
46 gastrointestinal neuroendocrine tumor 10.2 SST GAST
47 carcinoid tumors, intestinal 10.2 SST GAST
48 endometrial small cell carcinoma 10.2 PYY GAST
49 gastric antral vascular ectasia 10.2 SST GAST
50 tropical sprue 10.2 PYY GAST

Graphical network of the top 20 diseases related to Dumping Syndrome:



Diseases related to Dumping Syndrome
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Symptoms & Phenotypes for Dumping Syndrome

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UMLS symptoms related to Dumping Syndrome:


constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery
Sources

Drugs & Therapeutics for Dumping Syndrome

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Drugs for Dumping Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
lanreotide Approved Phase 4 108736-35-2
2
Pasireotide Approved Phase 4 396091-73-9 9941444
3
Empagliflozin Approved Phase 4 864070-44-0
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Cabergoline Approved Phase 4 81409-90-7 54746
6
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
7
Liraglutide Approved Phase 4 204656-20-2 44147092
8
Linagliptin Approved Phase 4 668270-12-0 10096344
9
Canagliflozin Approved Phase 4 842133-18-0
10
Lactitol Investigational Phase 4 585-86-4, 585-88-6 493591
11 Angiopeptin Phase 4
12 Hormone Antagonists Phase 4
13 Hormones Phase 4
14 Incretins Phase 4
15 Sodium-Glucose Transporter 2 Inhibitors Phase 4
16 Hypoglycemic Agents Phase 4
17 Neurotransmitter Agents Phase 4
18 Dopamine agonists Phase 4
19 Dopamine Agents Phase 4
20 Antiparkinson Agents Phase 4
21 Anti-Obesity Agents Phase 4
22 HIV Protease Inhibitors Phase 4
23
protease inhibitors Phase 4
24 Sitagliptin Phosphate Phase 4
25 Dipeptidyl-Peptidase IV Inhibitors Phase 4
26 Lipid Regulating Agents Phase 4
27
Hydrocodone Approved, Illicit, Investigational Phase 1 125-29-1 5284569
28
Guaifenesin Approved, Investigational, Vet_approved Phase 1 93-14-1 3516
29
Glucagon Approved Phase 1 16941-32-5
30
Exenatide Approved, Investigational Phase 1 141758-74-9 15991534
31 Analgesics Phase 1
32 Narcotics Phase 1
33 Respiratory System Agents Phase 1
34 Analgesics, Opioid Phase 1
35 Antitussive Agents Phase 1
36 Chlorpheniramine, phenylpropanolamine drug combination Phase 1
37 Central Nervous System Depressants Phase 1
38 Glucagon-Like Peptide 1 Phase 1
39
Loperamide Approved 53179-11-6 3955
40
Metformin Approved 657-24-9 14219 4091
41
Glimepiride Approved 93479-97-1 3476
42
Methylene blue Approved, Investigational 61-73-4
43
Somatostatin Approved, Investigational 51110-01-1, 38916-34-6 53481605
44
Octreotide Approved, Investigational 83150-76-9 383414 6400441
45
Acetaminophen Approved 103-90-2 1983
46
Sulfasalazine Approved 599-79-1 5353980 5359476
47
Rifaximin Approved, Investigational 80621-81-4 6436173 46783403
48 Antidiarrheals
49 Vitamins
50 Interleukin 1 Receptor Antagonist Protein

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
2 An Open Label, Multi-center Pasireotide Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Pasireotide Study and Are Judged by the Investigator to Benefit From Continued Pasireotide Treatment Recruiting NCT01794793 Phase 4 Pasireotide;Cabergoline;Pasireotide
3 Roux-en-Y Gastric Bypass for BMI 27-32 Type 2 Diabetes vs Best Medical Treatment Recruiting NCT02041234 Phase 4 Incretin analogues;Xenical;SGLT2 inhibitors;DPP-4 Inhibitors
4 Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass Recruiting NCT03984370 Phase 3 ZP4207
5 Multicenter Randomized Controlled Trial Comparing Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy for the Middle Third Early Gastric Cancer (KLASS-04) Recruiting NCT02595086 Phase 3
6 Hyperbaric Oxygenation (HBO) in Chronic Diabetic Leg Ulcer. Not yet recruiting NCT02042339 Phase 3 Hyperbaric oxygen
7 SOMATULINE Autogel 90 mg IN DUMPING SYNDROME Unknown status NCT01923649 Phase 2 Lanreotide 90 mg slow release formulation;Placebo
8 A Multi-center, Intra-patient Dose Escalation Phase II Study to Evaluate the Preliminary Efficacy, Safety and Pharmacokinetics of Pasireotide (SOM230) Subcutaneous (s.c.) Followed by Pasireotide LAR in Patients With Dumping Syndrome Completed NCT01637272 Phase 2 SOM230
9 Exploratory Randomized, Placebo-controlled Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome Completed NCT01895296 Phase 2 Pasireotide;Placebo
10 A Pilot Phase II Study of Hyperbaric Oxygen for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (HOPPS) Completed NCT01306968 Phase 2 hyperbaric oxygen
11 Subcutaneous Injection of Exendin (9-39) in Subjects With Hyperinsulinemic Hypoglycemia Post-Bariatric Surgery Unknown status NCT02996812 Phase 1 Exendin (9-39)
12 A Phase I, Double-Blind, Placebo-Controlled, Randomized, 3-Period, Safety and Pharmacokinetic Study of 13C-uracil in a Semi-solid Meal at Single Oral Doses of 50, 100, and 200 mg in Healthy Volunteers Completed NCT01074710 Phase 1 [2-13C] uracil;[2-13C] uracil, placebo
13 A Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Assess the Abuse Potential of the Hydrocodone Bitartrate Extended-Release Tablet in Healthy, Nondependent, Recreational Opioid Users Completed NCT01596673 Phase 1 45-mg hydrocodone bitartrate extended-release tablet (crushed or intact);Placebo
14 Treatment Plan for an Individual Patient With Pasireotide for Hyperinsulinemic Hypoglycemia Recruiting NCT03103009 Phase 1 Pasireotide
15 Visualizing Beta Cells in Patients With Hyperinsulinemic Hypoglycemia After Bariatric Surgery Recruiting NCT03182192 Phase 1
16 Comparisons Between Isoperistaltic and Antiperistaltic Gastrojejunostomy in Laparoscopic Distal Gastrectomy, Randomized Prospective Pilot Study Unknown status NCT02837874
17 Gastric Emptying: in Vivo Studies in Healthy Volunteers (Using Scrambled Egg and Porridge) to Determine Reliable Normal Ranges Unknown status NCT02994472
18 A Prospective Randomised Study Comparing Billroth II With Roux-en-Y Reconstruction After Radical Distal Subtotal Gastrectomy for Gastric Cancer Unknown status NCT01257711
19 Gastric Artery Embolization Trial for Lessening Appetite Nonsurgically (GET LEAN) Unknown status NCT02248688
20 Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients: a Prospective Controlled Trial. Unknown status NCT00873405
21 Prevalence of Medical and Nutritional Complications After Bariatric Surgery (Gastric Bypass) Based on a Clinical Trial Unknown status NCT01930838
22 Frequency of Occurrence of Dumping Syndrome After Operation of Esophageal Atresia Type III Completed NCT02525705
23 The Effect of Glucagon Like Peptide-1 (GLP-1) on Glycaemic Profile and Eating Behaviour Following Gastrectomy Completed NCT02971631
24 Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study Completed NCT03200782 Empagliflozin;Anakinra
25 Oral Glucosestimulation After Gastric Bypass Surgery Completed NCT01851616
26 Incidence of Medical and Nutritional Complications After Bariatric Surgery, Especially Focusing on Assessment and Treatment of Severe Hypoglycemia Completed NCT01865760 Octreotide
27 Prevalence of Idiopathic Reactive Hypoglycaemia and Impact of Fructo-Oligosaccharide Supplementation on Blood Glucose Variability Completed NCT00802971
28 Postoperative Dietary Counseling After Bariatric Surgery Completed NCT00125073
29 Role of Glucagon-Like Peptide-1 in Postprandial Hypoglycemia After Nissen Fundoplication: Studies With the GLP-1 Receptor Antagonist Exendin-(9-39) Completed NCT01162499 Exendin-(9-39)
30 Meal Stimulating After Roux-en Y Gastric Bypass Completed NCT00915980
31 Prevalence of Medical and Nutritional Complications After Bariatric Surgery (Gastric Bypass) Based on a Questionnaire Survey Completed NCT01930851
32 The Effect of Food on the Pharmacokinetics of Metformin Given Either as Metformin Hydrochloride SR 1000mg Tablet or as a Fixed Dose Combination of Metformin Hydrochloride SR 1000mg/Glimepiride 2mg Tablet in Healthy Indian Volunteers. Completed NCT01561976 Metformin hydrochloride prolonged release;metformin hydrochloride prolonged release;Metformin hydrochloride sustained release/Glimepiride
33 The Effect of Fat Supplementation on the Appearance of Symptoms Associated With Dumping Syndrome in Patients Undergone Bariatric Surgery Recruiting NCT04028193
34 Assessing the Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity With the Risk of Occurrence of Dumping Syndrome After Gastric Bypass. Recruiting NCT02891330
35 Incidence of Dumping Syndrome After Laparoscopic Vagus Nerve-preserving Distal Gastrectomy for Early Gastric Cancer Recruiting NCT03880747
36 Functional Outcome Following Ivor-Lewis Oesophagectomy Recruiting NCT03658837
37 Gastric Cancer Sentinel Lymph Node Sampling: Refining Patient Selection for Organ Sparing Resection of Early Gastric Cancer in a North American Context Recruiting NCT03049345 Radioactive Tracers;Methylene Blue 20 MG/ML
38 Cohorte Obésité Bichat LOuis Mourier Recruiting NCT03538210
39 European Dumping Study: Validation of a Diagnostic Tool for Postprandial Hypoglycaemia in Patients After Roux en Y Gastric Bypass Surgery Recruiting NCT03406312
40 Mayo Clinic Conduit Report Card Questionnaires Recruiting NCT02530983
41 A 90 Day, Phase 4, Open Labeled Exploratory Study of RELiZORB to Evaluate Safety, Tolerability, and Nutrient Absorption in Children With Short Bowel Syndrome Who Are Dependent on Parenteral Nutrition Recruiting NCT03530852
42 Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes Recruiting NCT04001842
43 ENSURE: European iNvestigation of SUrveillance After Resection for Esophageal Cancer Active, not recruiting NCT03461341
44 An Intervention Model for the Prevention of Infertility in Healthy Young Men Living in Highly Polluted Areas Active, not recruiting NCT04012385
45 Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery Enrolling by invitation NCT03734627 Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine
46 Applying Nutrient Drink Test in Understanding Pathophysiology of Cyclic Vomiting Syndrome Enrolling by invitation NCT03470181
47 Role and Mechanisms of Obesity Surgery - Physical Activity and Other Predictors of Hospital Stay, Recovery and Complications After Obesity Surgery Suspended NCT01998815
48 The Metabolic Consequences of Gastrointestinal Surgery Terminated NCT02836353 Somatostatin;Rifaximin
49 Evaluation of an Intervention (Consisting of an Electronic Reminder Device, Pillboxes, and Monthly Telephone Calls) on Adherence to Highly Active Antiretroviral Therapy (HAART) in HIV Infected Adults Terminated NCT00203853
50 Pilot Study: Assessment of Gastric and Intestinal Motility Following a Trigger Meal in Patients With Post Prandial Diarrhea Withdrawn NCT01114113 pancelipase/placebo

Search NIH Clinical Center for Dumping Syndrome

Cochrane evidence based reviews: dumping syndrome

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Genetic Tests for Dumping Syndrome

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Anatomical Context for Dumping Syndrome

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MalaCards organs/tissues related to Dumping Syndrome:

40
Small Intestine, Testes, Colon, Pituitary, Liver, Lung, Brain
Sources

Publications for Dumping Syndrome

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Articles related to Dumping Syndrome:

(show top 50) (show all 3592)
# Title Authors PMID Year
1
Pathophysiology, diagnosis and management of postoperative dumping syndrome. 54 61
19724252 2009
2
Efficacy of the long-acting repeatable formulation of the somatostatin analogue octreotide in postoperative dumping. 54 61
19264574 2009
3
A possible role of GLP-1 in the pathophysiology of early dumping syndrome. 54 61
16416173 2005
4
Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome. 54 61
11575444 2001
5
Gastrointestinal hormone in dumping syndrome and reflux esophagitis after gastric surgery. 54 61
9403815 1997
6
The dumping syndrome. Current insights into pathophysiology, diagnosis and treatment. 54 61
9200302 1997
7
[Neurohumoral regulation of gastric secretion in postvagotomy syndromes]. 54 61
7933883 1994
8
[Postgastrectomy dumping treated with octreotide (Sandostatin)]. 54 61
8317033 1993
9
The effect of somatostatin in dumping syndrome after gastric surgery. 54 61
8103615 1993
10
Atrial natriuretic peptide in dumping syndrome. 54 61
8513987 1993
11
Potential indications for octreotide in gastroenterology: summary of workshop. 54 61
8359570 1993
12
Dumping syndrome and the regulation of peptide YY with verapamil. 54 61
1415124 1992
13
Decreased activity of atrial natriuretic peptide in dumping syndrome after gastric surgery. 54 61
1830840 1991
14
[The effect of somatostatin in dumping syndrome]. 54 61
1978748 1990
15
[Atrial natriuretic peptide in dumping syndrome]. 54 61
2146582 1990
16
Ecological influences of the migration of micro resin particles from crushed waste printed circuit boards on the dumping soil. 61
31874765 2020
17
Estimating the effectiveness of different environmental law enforcement policies on illegal C&D waste dumping in Israel. 61
31698228 2020
18
Characterizing the implications of waste dumping surrounding the Yangtze River economic belt in China. 61
31539664 2020
19
Once-Daily Oxycodone Prolonged-Release Tablets Are Resistant to Alcohol-Induced Dose Dumping: Results From a Randomized Trial in Healthy Volunteers. 61
32027446 2020
20
Industrial wastes: Fly ash, steel slag and phosphogypsum- potential candidates to mitigate greenhouse gas emissions from paddy fields. 61
31590026 2020
21
Prostaglandin D2 synthase and its functional association with immune and reproductive processes in a lepidopteran insect, Spodoptera exigua. 61
31794733 2020
22
Total oesophago-gastric dissociation in neurologically impaired children: Laparoscopic vs robotic approach. 61
31797517 2020
23
Waste paper: An underutilized but promising source for nanocellulose mining. 61
31704510 2020
24
The challenges of applying an Activity-Based Sampling methodology to estimate the cancer risk associated with asbestos contaminated landfilled zones. 61
31784077 2020
25
Informal Emptying Business in Mandalay: Its Reasons and Financial Impacts. 61
31828411 2020
26
Evidence for Relationship Between Early Dumping and Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass. 61
31907828 2020
27
Data-driven analytical framework for waste-dumping behaviour analysis to facilitate policy regulations. 61
31911375 2020
28
Let's stop dumping cookstoves in local communities. It's time to get implementation right. 61
31924825 2020
29
Predictors of Beta-Hexachlorocyclohexane blood levels among people living close to a chemical plant and an illegal dumping site. 61
31969154 2020
30
The 2016 red tide crisis in southern Chile: Possible influence of the mass oceanic dumping of dead salmons. 61
31784267 2020
31
Utility of continuous glucose monitoring following gastrectomy. 61
31916026 2020
32
Dumping STAT3 in the trash. 61
31907421 2020
33
Comparison of Measurement Methods for Dermal Exposure to Hazardous Chemicals at the Workplace: The SysDEA Project. 61
31785203 2020
34
Production, purification and evaluation of biodegradation potential of PHB depolymerase of Stenotrophomonas sp. RZS7. 61
31910206 2020
35
Contamination of soil with potentially toxic metals and their bioaccumulation in wheat and associated health risk. 61
31980942 2020
36
Adaptive co-management model for the East Kolkata wetlands: A sustainable solution to manage the rapid ecological transformation of a peri-urban landscape. 61
31783445 2020
37
Albatrosses and petrels at South Georgia as sentinels of marine debris input from vessels in the southwest Atlantic Ocean. 61
31927465 2020
38
High level of exposure to hepatitis B virus infection in a vulnerable population of a low endemic area: A challenge for vaccination coverage. 61
31589921 2020
39
Roux-en-Y Gastric Bypass Reversal: A Novel Technique With Functional Reversal - Case Series. 61
31970656 2020
40
Microplastic concentrations, size distribution, and polymer types in the surface waters of a northern European lake. 61
31469932 2020
41
Community Health Survey of Residents Living Near a Solid Waste Open Dumpsite in Sabak, Kelantan, Malaysia. 61
31906421 2020
42
Achieving low-cost, highly selective nitrate removal with standard anion exchange resin by tuning recycled brine composition. 61
32035280 2020
43
Curved corannulene dually targets mitochondria and endoplasmic reticulum, and initiates apoptosis via localized ROS induction upon light triggering. 61
31753352 2020
44
Benthic marine debris in the Bay of Fundy, eastern Canada: Spatial distribution and categorization using seafloor video footage. 61
31733907 2020
45
Seasonal variation in aragonite saturation states and the controlling factors in the southeastern Yellow Sea. 61
31740181 2020
46
Use of GreenZyme® for remediation of porous media polluted with jet fuel JP-5. 61
29969373 2020
47
Laparoscopic Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy for Type 2 Diabetes Mellitus in Nonseverely Obese Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 61
31912466 2020
48
Gastroparesis versus dyspepsia by intragastric meal distribution: new diagnostics and definitions ahead. 61
31928242 2020
49
Frequency of Abnormal Glucose Tolerance Test Suggestive of Dumping Syndrome Following œsophageal Atresia Repair. 61
32000165 2020
50
Usefulness of Continuous Glucose Monitoring for Prevention and Early Detection of Hypoglycemia Caused by a Ketogenic Diet and Late Dumping Syndrome. 61
32029333 2019
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Variations for Dumping Syndrome

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Expression for Dumping Syndrome

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Search GEO for disease gene expression data for Dumping Syndrome.
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Pathways for Dumping Syndrome

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Pathways related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 13.69 SST SCT PYY NTS MLN INS
2
Peptide ligand-binding receptors 65
Show member pathways
 12.89 SST SCT PYY NTS MLN GIP
3
cAMP signaling pathway 36
12 SST GIP GHRL GCG
4
Peptide hormone metabolism 65
Show member pathways
 11.88 INS GIP GHRL GCG
5
G alpha (s) signalling events 65
11.77 SCT GIP GCG
6
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.63 PYY INS GHRL
7
Digestion of dietary carbohydrate 65
10.36 SI MGAM
8
Gastric acid production 1
9.64 SCT GAST CCK
Sources

GO Terms for Dumping Syndrome

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Cellular components related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 SST SCT PYY INS GIP GHRL
2 endoplasmic reticulum lumen GO:0005788 9.56 INS GIP GHRL GCG
3 secretory granule lumen GO:0034774 9.46 INS GIP GHRL GCG
4 extracellular region GO:0005576 9.36 SST SCT PYY NTS MLN INS

Biological processes related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to amino acid GO:0043200 9.46 SST GIP
2 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.43 GHRL GCG
3 feeding behavior GO:0007631 9.4 PYY GCG
4 digestion GO:0007586 9.37 SST CCK
5 G protein-coupled receptor signaling pathway GO:0007186 9.36 SST SCT PYY NTS MLN INS
6 positive regulation of cAMP-mediated signaling GO:0043950 9.32 SCT GIP
7 response to acidic pH GO:0010447 9.26 SST GIP
8 polysaccharide digestion GO:0044245 9.16 SI MGAM
9 response to nutrient levels GO:0031667 9.13 SCT GIP GHRL

Molecular functions related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.33 SCT PYY GHRL
2 hormone activity GO:0005179 9.32 SST SCT PYY MLN INS GIP
3 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.26 SI MGAM
4 neuropeptide hormone activity GO:0005184 9.13 PYY NTS CCK
Sources

Sources for Dumping Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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