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MCID: DMP001
MIFTS: 44

Dumping Syndrome

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Dumping Syndrome

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MalaCards integrated aliases for Dumping Syndrome:

Name: Dumping Syndrome 12 54 43 15 17 71
Dumping 54 71
Postgastrectomy Syndromes 71
Dumping Syndrome 12
Jejunal Syndrome 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:14495
MeSH 43 D004377
NCIt 49 C2994
ICD10 32 K91.1
UMLS 71 C0013288 C0032763 C0221542
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Summaries for Dumping Syndrome

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MalaCards based summary : Dumping Syndrome, also known as dumping, is related to hyperinsulinemic hypoglycemia and hypoglycemia, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Dumping Syndrome is GCG (Glucagon), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs lanreotide and Pasireotide have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver.

Wikipedia : 74 Dumping syndrome occurs when food, especially sugar, moves too quickly from the stomach to the... more...

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Related Diseases for Dumping Syndrome

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Diseases related to Dumping Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia 30.5 SST INS GCG
2 hypoglycemia 30.4 SST INS GHRL GCG GAST
3 hyperinsulinism 30.1 SST INS GHRL GCG
4 peptic esophagitis 29.9 SCT MLN GAST
5 pyloric stenosis 29.9 SST MLN GAST
6 peptic ulcer disease 29.8 SST SCT INS GHRL GAST
7 biliary dyskinesia 29.7 SST SCT CCK
8 leptin deficiency or dysfunction 29.6 PYY INS GHRL GCG CCK
9 bile reflux 29.5 SCT GAST CCK
10 glucose intolerance 29.5 INS GHRL GCG
11 insulinoma 29.5 SST SCT INS GCG GAST
12 duodenal ulcer 29.4 SST SCT MLN INS GAST CCK
13 gastritis 29.2 SST SCT GHRL GAST
14 gastroesophageal reflux 28.9 PYY NTS MLN GHRL GCG GAST
15 irritable bowel syndrome 28.8 SST PYY MLN GHRL CCK
16 hyperglycemia 28.8 SST PYY INS GIP GHRL GCG
17 gastrointestinal system disease 28.8 MLN GHRL GCG GAST CCK
18 gastroparesis 28.6 SST MLN GIP GHRL GAST CCK
19 duodenogastric reflux 28.4 SST SCT PYY NTS MLN GAST
20 short bowel syndrome 28.1 SST PYY NTS GHRL GCG GAST
21 diabetes mellitus, type i 28.1 SST SI SCT MGAM INS GCG
22 diarrhea 27.7 SST SI SCT PYY NTS MLN
23 constipation 27.5 SST PYY NTS MLN INS GHRL
24 diabetes mellitus, noninsulin-dependent 25.8 SST SI SCT PYY NTS MGAM
25 petrositis 10.4 SST GCG
26 acute insulin response 10.4 INS GCG
27 adenosquamous bile duct carcinoma 10.4 GIP GCG
28 pituitary infarct 10.3 SST INS
29 duodenal somatostatinoma 10.3 SST INS
30 acidophil adenoma 10.3 SST INS
31 functional colonic disease 10.3 SST MLN
32 angular cheilitis 10.3 SST GCG
33 colonic pseudo-obstruction 10.3 SST MLN
34 meckel diverticulum 10.3 SST GCG
35 transient refractive change 10.3 SST INS
36 gastrointestinal neuroendocrine benign tumor 10.3 SST GAST
37 non-functioning pancreatic endocrine tumor 10.3 SST GAST
38 rectum neuroendocrine neoplasm 10.3 SST GAST
39 maturity-onset diabetes of the young, type 2 10.3 INS GCG
40 pituitary apoplexy 10.3 SST INS
41 gastric neuroendocrine neoplasm 10.3 SST GAST
42 appendix lymphoma 10.3 SST GAST
43 gastrointestinal neuroendocrine tumor 10.2 SST GAST
44 carcinoid tumors, intestinal 10.2 SST GAST
45 hyperpituitarism 10.2 SST INS
46 pancreas disease 10.2 SST INS GCG
47 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
48 gastric antral vascular ectasia 10.2 SST GAST
49 functionless pituitary adenoma 10.2 SST CCK
50 pancreatoblastoma 10.2 SST NTS

Graphical network of the top 20 diseases related to Dumping Syndrome:



Diseases related to Dumping Syndrome
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Symptoms & Phenotypes for Dumping Syndrome

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UMLS symptoms related to Dumping Syndrome:


constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery
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Drugs & Therapeutics for Dumping Syndrome

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Drugs for Dumping Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
lanreotide Approved Phase 4 108736-35-2
2
Pasireotide Approved Phase 4 396091-73-9 9941444
3
Empagliflozin Approved Phase 4 864070-44-0
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Cabergoline Approved Phase 4 81409-90-7 54746
6
Lactitol Approved, Investigational Phase 4 585-88-6, 585-86-4 493591
7
Linagliptin Approved Phase 4 668270-12-0 10096344
8
Liraglutide Approved Phase 4 204656-20-2 44147092
9
Canagliflozin Approved Phase 4 842133-18-0
10
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
11 Angiopeptin Phase 4
12 Hormone Antagonists Phase 4
13 Hormones Phase 4
14 Hypoglycemic Agents Phase 4
15 Sodium-Glucose Transporter 2 Inhibitors Phase 4
16 Dopamine Agents Phase 4
17 Dopamine agonists Phase 4
18 Antiparkinson Agents Phase 4
19 Neurotransmitter Agents Phase 4
20 Incretins Phase 4
21 Anti-Obesity Agents Phase 4
22 Dipeptidyl-Peptidase IV Inhibitors Phase 4
23
protease inhibitors Phase 4
24 HIV Protease Inhibitors Phase 4
25 Lipid Regulating Agents Phase 4
26 Sitagliptin Phosphate Phase 4
27
Hydrocodone Approved, Illicit, Investigational Phase 1 125-29-1 5284569
28
Guaifenesin Approved, Investigational, Vet_approved Phase 1 93-14-1 3516
29
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
30
Glucagon Approved Phase 1 16941-32-5
31
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441
32
Exenatide Approved, Investigational Phase 1 141758-74-9 15991534
33 Analgesics Phase 1
34 Respiratory System Agents Phase 1
35 Narcotics Phase 1
36 Antitussive Agents Phase 1
37 Analgesics, Opioid Phase 1
38 Chlorpheniramine, phenylpropanolamine drug combination Phase 1
39 Insulin, Globin Zinc Phase 1
40 insulin Phase 1
41 Glucagon-Like Peptide 1 Phase 1
42
Loperamide Approved 53179-11-6 3955
43
Metformin Approved 657-24-9 14219 4091
44
Glimepiride Approved 93479-97-1 3476
45
Methylene blue Approved, Investigational 61-73-4
46
Acetaminophen Approved 103-90-2 1983
47
Sulfasalazine Approved 599-79-1 5353980 5359476
48
Rifaximin Approved, Investigational 80621-81-4 6436173 46783403
49
Trichostatin A Experimental 58880-19-6
50 Antidiarrheals

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
2 An Open Label, Multi-center Pasireotide Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Pasireotide Study and Are Judged by the Investigator to Benefit From Continued Pasireotide Treatment Active, not recruiting NCT01794793 Phase 4 Pasireotide;Cabergoline;Pasireotide
3 Roux-en-Y Gastric Bypass for BMI 27-32 Type 2 Diabetes vs Best Medical Treatment Active, not recruiting NCT02041234 Phase 4 Incretin analogues;Xenical;SGLT2 inhibitors;DPP-4 Inhibitors
4 Multicenter Randomized Controlled Trial Comparing Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy for the Middle Third Early Gastric Cancer (KLASS-04) Recruiting NCT02595086 Phase 3
5 Hyperbaric Oxygenation (HBO) in Chronic Diabetic Leg Ulcer. Not yet recruiting NCT02042339 Phase 3 Hyperbaric oxygen
6 SOMATULINE Autogel 90 mg IN DUMPING SYNDROME Unknown status NCT01923649 Phase 2 Lanreotide 90 mg slow release formulation;Placebo
7 A Multi-center, Intra-patient Dose Escalation Phase II Study to Evaluate the Preliminary Efficacy, Safety and Pharmacokinetics of Pasireotide (SOM230) Subcutaneous (s.c.) Followed by Pasireotide LAR in Patients With Dumping Syndrome Completed NCT01637272 Phase 2 SOM230
8 Exploratory Randomized, Placebo-controlled Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome Completed NCT01895296 Phase 2 Pasireotide;Placebo
9 Dasiglucagon in the Treatment of Postprandial Hypoglycaemia After Roux-en-Y Gastric Bypass Completed NCT03984370 Phase 2 ZP4207
10 A Pilot Phase II Study of Hyperbaric Oxygen for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (HOPPS) Completed NCT01306968 Phase 2 hyperbaric oxygen
11 Subcutaneous Injection of Exendin (9-39) in Subjects With Hyperinsulinemic Hypoglycemia Post-Bariatric Surgery Unknown status NCT02996812 Phase 1 Exendin (9-39)
12 A Phase I, Double-Blind, Placebo-Controlled, Randomized, 3-Period, Safety and Pharmacokinetic Study of 13C-uracil in a Semi-solid Meal at Single Oral Doses of 50, 100, and 200 mg in Healthy Volunteers Completed NCT01074710 Phase 1 [2-13C] uracil;[2-13C] uracil, placebo
13 A Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Assess the Abuse Potential of the Hydrocodone Bitartrate Extended-Release Tablet in Healthy, Nondependent, Recreational Opioid Users Completed NCT01596673 Phase 1 45-mg hydrocodone bitartrate extended-release tablet (crushed or intact);Placebo
14 Treatment Plan for an Individual Patient With Pasireotide for Hyperinsulinemic Hypoglycemia Recruiting NCT03103009 Phase 1 Pasireotide
15 Visualizing Beta Cells in Patients With Hyperinsulinemic Hypoglycemia After Bariatric Surgery Recruiting NCT03182192 Phase 1
16 Comparisons Between Isoperistaltic and Antiperistaltic Gastrojejunostomy in Laparoscopic Distal Gastrectomy, Randomized Prospective Pilot Study Unknown status NCT02837874
17 Gastric Emptying: in Vivo Studies in Healthy Volunteers (Using Scrambled Egg and Porridge) to Determine Reliable Normal Ranges Unknown status NCT02994472
18 A Prospective Randomised Study Comparing Billroth II With Roux-en-Y Reconstruction After Radical Distal Subtotal Gastrectomy for Gastric Cancer Unknown status NCT01257711
19 Gastric Artery Embolization Trial for Lessening Appetite Nonsurgically (GET LEAN) Unknown status NCT02248688
20 Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients: a Prospective Controlled Trial. Unknown status NCT00873405
21 European Dumping Study: Validation of a Diagnostic Tool for Postprandial Hypoglycaemia in Patients After Roux en Y Gastric Bypass Surgery Unknown status NCT03406312
22 Prevalence of Medical and Nutritional Complications After Bariatric Surgery (Gastric Bypass) Based on a Clinical Trial Unknown status NCT01930838
23 Frequency of Occurrence of Dumping Syndrome After Operation of Esophageal Atresia Type III Completed NCT02525705
24 The Effect of Glucagon Like Peptide-1 (GLP-1) on Glycaemic Profile and Eating Behaviour Following Gastrectomy Completed NCT02971631
25 Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study Completed NCT03200782 Empagliflozin;Anakinra
26 Oral Glucosestimulation After Gastric Bypass Surgery Completed NCT01851616
27 Prevalence of Idiopathic Reactive Hypoglycaemia and Impact of Fructo-Oligosaccharide Supplementation on Blood Glucose Variability Completed NCT00802971
28 Incidence of Medical and Nutritional Complications After Bariatric Surgery, Especially Focusing on Assessment and Treatment of Severe Hypoglycemia Completed NCT01865760 Octreotide
29 ENSURE: European iNvestigation of SUrveillance After Resection for Esophageal Cancer Completed NCT03461341
30 Postoperative Dietary Counseling After Bariatric Surgery Completed NCT00125073
31 Role of Glucagon-Like Peptide-1 in Postprandial Hypoglycemia After Nissen Fundoplication: Studies With the GLP-1 Receptor Antagonist Exendin-(9-39) Completed NCT01162499 Exendin-(9-39)
32 Meal Stimulating After Roux-en Y Gastric Bypass Completed NCT00915980
33 Applying Nutrient Drink Test in Understanding Pathophysiology of Cyclic Vomiting Syndrome Completed NCT03470181
34 Prevalence of Medical and Nutritional Complications After Bariatric Surgery (Gastric Bypass) Based on a Questionnaire Survey Completed NCT01930851
35 The Effect of Food on the Pharmacokinetics of Metformin Given Either as Metformin Hydrochloride SR 1000mg Tablet or as a Fixed Dose Combination of Metformin Hydrochloride SR 1000mg/Glimepiride 2mg Tablet in Healthy Indian Volunteers. Completed NCT01561976 Metformin hydrochloride prolonged release;metformin hydrochloride prolonged release;Metformin hydrochloride sustained release/Glimepiride
36 An Intervention Model for the Prevention of Infertility in Healthy Young Men Living in Highly Polluted Areas Completed NCT04012385
37 The Effect of Fat Supplementation on the Appearance of Symptoms Associated With Dumping Syndrome in Patients Undergone Bariatric Surgery Recruiting NCT04028193
38 Assessing the Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity With the Risk of Occurrence of Dumping Syndrome After Gastric Bypass. Recruiting NCT02891330
39 Incidence of Dumping Syndrome After Laparoscopic Vagus Nerve-preserving Distal Gastrectomy for Early Gastric Cancer Recruiting NCT03880747
40 Functional Outcome Following Ivor-Lewis Oesophagectomy Recruiting NCT03658837
41 Gastric Cancer Sentinel Lymph Node Sampling: Refining Patient Selection for Organ Sparing Resection of Early Gastric Cancer in a North American Context Recruiting NCT03049345 Radioactive Tracers;Methylene Blue 20 MG/ML
42 Cohorte Obésité Bichat LOuis Mourier Recruiting NCT03538210
43 Mayo Clinic Conduit Report Card Questionnaires Recruiting NCT02530983
44 A 90 Day, Phase 4, Open Labeled Exploratory Study of RELiZORB to Evaluate Safety, Tolerability, and Nutrient Absorption in Children With Short Bowel Syndrome Who Are Dependent on Parenteral Nutrition Recruiting NCT03530852
45 Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes Recruiting NCT04001842
46 Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery Enrolling by invitation NCT03734627 Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine
47 Role and Mechanisms of Obesity Surgery - Physical Activity and Other Predictors of Hospital Stay, Recovery and Complications After Obesity Surgery Suspended NCT01998815
48 The Metabolic Consequences of Gastrointestinal Surgery Terminated NCT02836353 Somatostatin;Rifaximin
49 Evaluation of an Intervention (Consisting of an Electronic Reminder Device, Pillboxes, and Monthly Telephone Calls) on Adherence to Highly Active Antiretroviral Therapy (HAART) in HIV Infected Adults Terminated NCT00203853
50 Pilot Study: Assessment of Gastric and Intestinal Motility Following a Trigger Meal in Patients With Post Prandial Diarrhea Withdrawn NCT01114113 pancelipase/placebo

Search NIH Clinical Center for Dumping Syndrome

Cochrane evidence based reviews: dumping syndrome

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Genetic Tests for Dumping Syndrome

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Anatomical Context for Dumping Syndrome

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MalaCards organs/tissues related to Dumping Syndrome:

40
Small Intestine, Testes, Liver, Brain, Colon, Lymph Node, Lung
Sources

Publications for Dumping Syndrome

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Articles related to Dumping Syndrome:

(show top 50) (show all 3651)
# Title Authors PMID Year
1
Pathophysiology, diagnosis and management of postoperative dumping syndrome. 61 54
19724252 2009
2
Efficacy of the long-acting repeatable formulation of the somatostatin analogue octreotide in postoperative dumping. 54 61
19264574 2009
3
A possible role of GLP-1 in the pathophysiology of early dumping syndrome. 54 61
16416173 2005
4
Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome. 61 54
11575444 2001
5
Gastrointestinal hormone in dumping syndrome and reflux esophagitis after gastric surgery. 61 54
9403815 1997
6
The dumping syndrome. Current insights into pathophysiology, diagnosis and treatment. 54 61
9200302 1997
7
[Neurohumoral regulation of gastric secretion in postvagotomy syndromes]. 61 54
7933883 1994
8
[Postgastrectomy dumping treated with octreotide (Sandostatin)]. 61 54
8317033 1993
9
The effect of somatostatin in dumping syndrome after gastric surgery. 61 54
8103615 1993
10
Atrial natriuretic peptide in dumping syndrome. 61 54
8513987 1993
11
Potential indications for octreotide in gastroenterology: summary of workshop. 61 54
8359570 1993
12
Dumping syndrome and the regulation of peptide YY with verapamil. 61 54
1415124 1992
13
Decreased activity of atrial natriuretic peptide in dumping syndrome after gastric surgery. 54 61
1830840 1991
14
[The effect of somatostatin in dumping syndrome]. 54 61
1978748 1990
15
[Atrial natriuretic peptide in dumping syndrome]. 61 54
2146582 1990
16
Editorial: New Research on Soil Degradation and Restoration. 61
32561024 2020
17
Optimization of the culture conditions for production of Polyhydroxyalkanoate and its characterization from a new Bacillus cereus sp. BNPI-92 strain, isolated from plastic waste dumping yard. 61
31751740 2020
18
The Prognostic Value of the Dutch Sweet Eating Questionnaire on Weight Loss After Metabolic Surgery: a Randomized Controlled Trial. 61
32170552 2020
19
Long-term monitoring emphasizes impacts of the dredging on dissolved Cu and Pb contamination along with ultraplankton distribution and structure in Toulon Bay (NW Mediterranean Sea, France). 61
32510358 2020
20
A School of Nursing's Response to Hurricane Harvey. 61
31335491 2020
21
Soft-bottom community responses in a marine area influenced by recurrent dumping activities and freshwater discharges. 61
32510401 2020
22
Utility of continuous glucose monitoring following gastrectomy. 61
31916026 2020
23
14 Years' experience of esophageal replacement surgeries. 61
32236666 2020
24
Mechanisms underlying the association between periodontitis and atherosclerotic disease. 61
32385879 2020
25
Once-Weekly Subcutaneous Delivery of Polymer-Linked Rotigotine (SER-214) Provides Continuous Plasma Levels in Parkinson's Disease Patients. 61
32251552 2020
26
Potential of Black Soldier Fly Production for Pacific Small Island Developing States. 61
32560146 2020
27
Processes of chromium (VI) migration and transformation in chromate production site: A case study from the middle of China. 61
32531491 2020
28
Electrical resistivity imaging for detection of hydrogeological active zones in karst areas to identify the site of mining waste disposal. 61
32319050 2020
29
Development of sustainable approaches for converting the organic waste to bioenergy. 61
32229385 2020
30
Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study. 61
31838757 2020
31
Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver. 61
32045807 2020
32
Why We Think Laparoscopic Sleeve Gastrectomy Is a Good Operation: Step-by-Step Technique. 61
32319850 2020
33
Assessment of the use of dredged marine materials in sanitary landfills: A case study from the Marmara sea. 61
32505977 2020
34
Early experience with a nutrition and survivorship clinic in esophageal cancer. 61
32566939 2020
35
Review of the management of diarrhea syndrome after a bariatric surgery. 61
31843494 2020
36
Frequency of Abnormal Glucose Tolerance Test Suggestive of Dumping Syndrome Following Oesophageal Atresia Repair. 61
32443041 2020
37
Alcohol and gastric motility: pathophysiological and therapeutic implications. 61
32447287 2020
38
Endoscopic Botulinum toxin as a treatment for delayed gastric emptying following oesophagogastrectomy. 61
32538118 2020
39
Triggering of different pulsed regimes in fiber cavity laser by a waveguide electro-optic switch. 61
32403525 2020
40
Application of Systems Thinking to the assessment of an institutional development project of river restoration at a campus university in Southern Brazil. 61
31713136 2020
41
An Overview of Adolescents Sexual and Reproductive Health Services Provision in Malaysia. 61
32442024 2020
42
A State-of-the-Art Review of Indigenous Peoples and Environmental Pollution. 61
31863549 2020
43
Biochar aided aromatic grass [Cymbopogon martini (Roxb.) Wats.] vegetation: A sustainable method for stabilization of highly acidic mine waste. 61
31818656 2020
44
Keratinolytic enzyme-mediated biodegradation of recalcitrant poultry feathers waste by newly isolated Bacillus sp. NKSP-7 under submerged fermentation. 61
32415568 2020
45
Integrated geophysical and geochemical methods applied for recognition of acid waste drainage (AWD) from Zn-Pb post-flotation tailing pile (Olkusz, southern Poland). 61
32133608 2020
46
Health Risk Assessment and Source Apportionment for Heavy Metals in a Southern Chinese Reservoir Impacted by Stone Mining Activities. 61
31746539 2020
47
Mixed culture of Lactococcus lactis and Kluyveromyces marxianus isolated from kefir grains for pollutants load removal from Jebel Chakir leachate. 61
32449943 2020
48
Waste generation and management status in the fast-expanding Indian cities: A review. 61
32150518 2020
49
Deletion mutant of PGE2 receptor using CRISPR-Cas9 exhibits larval immunosuppression and adult infertility in a lepidopteran insect, Spodoptera exigua. 61
32464135 2020
50
Laparoscopic Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy for Type 2 Diabetes Mellitus in Nonseverely Obese Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 61
31912466 2020
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Variations for Dumping Syndrome

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Expression for Dumping Syndrome

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Search GEO for disease gene expression data for Dumping Syndrome.
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Pathways for Dumping Syndrome

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Pathways related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 13.69 SST SCT PYY NTS MLN INS
2
Peptide ligand-binding receptors 65
Show member pathways
 12.89 SST SCT PYY NTS MLN GIP
3
cAMP signaling pathway 36
12 SST GIP GHRL GCG
4
Peptide hormone metabolism 65
Show member pathways
 11.88 INS GIP GHRL GCG
5
G alpha (s) signalling events 65
11.77 SCT GIP GCG
6
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.63 PYY INS GHRL
7
Digestion of dietary carbohydrate 65
10.36 SI MGAM
8
Gastric acid production 1
9.64 SCT GAST CCK
Sources

GO Terms for Dumping Syndrome

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Cellular components related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 SST SCT PYY INS GIP GHRL
2 endoplasmic reticulum lumen GO:0005788 9.56 INS GIP GHRL GCG
3 secretory granule lumen GO:0034774 9.46 INS GIP GHRL GCG
4 extracellular region GO:0005576 9.36 SST SCT PYY NTS MLN INS

Biological processes related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to amino acid GO:0043200 9.43 SST GIP
2 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.4 GHRL GCG
3 digestion GO:0007586 9.37 SST CCK
4 G protein-coupled receptor signaling pathway GO:0007186 9.36 SST SCT PYY NTS MLN INS
5 response to nutrient levels GO:0031667 9.33 SCT GIP GHRL
6 positive regulation of cAMP-mediated signaling GO:0043950 9.32 SCT GIP
7 response to acidic pH GO:0010447 9.26 SST GIP
8 polysaccharide digestion GO:0044245 8.96 SI MGAM

Molecular functions related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.43 SCT PYY GHRL
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.32 SI MGAM
3 hormone activity GO:0005179 9.32 SST SCT PYY MLN INS GIP
4 glucagon receptor binding GO:0031769 9.16 GIP GCG
5 neuropeptide hormone activity GO:0005184 9.13 PYY NTS CCK
Sources

Sources for Dumping Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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