Dumping Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DMP001 MIFTS: 44	Dumping Syndrome Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Download Expand all tables

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Aliases & Classifications for Dumping Syndrome

MalaCards integrated aliases for Dumping Syndrome:

Name: Dumping Syndrome ¹² ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Dumping ⁵⁵ ⁷³

Postgastrectomy Syndromes ⁷³

Dumping Syndrome ¹²

Jejunal Syndrome ¹²

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the digestive system

Other diseases of the digestive system

Postprocedural disorders of digestive system, not elsewhere classified

Postgastric surgery syndromes

External Ids:

Disease Ontology ¹² DOID:14495

ICD10 ³³ K91.1

MeSH ⁴⁴ D004377

NCIt ⁵⁰ C2994

SNOMED-CT ⁶⁸ 155785007 197128007 266458008 more

UMLS ⁷³ C0013288 C0221542

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Summaries for Dumping Syndrome

MalaCards based summary : Dumping Syndrome, also known as dumping, is related to hyperinsulinemic hypoglycemia and gastroesophageal reflux, and has symptoms including constipation, pain, postoperative and vomiting following gastrointestinal surgery. An important gene associated with Dumping Syndrome is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs lanreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver.

Wikipedia : ⁷⁶ Dumping syndrome occurs when food, especially sugar, moves too fast from the stomach to the duodenum—the... more...

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Related Diseases for Dumping Syndrome

Diseases related to Dumping Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)

#	Related Disease	Score	Top Affiliating Genes
1	hyperinsulinemic hypoglycemia	29.7	INS SST
2	gastroesophageal reflux	29.2	GCG NTS PYY
3	duodenal ulcer	29.1	INS SCT SST
4	constipation	29.0	NTS PYY SST
5	insulinoma	28.4	GCG INS SCT SST
6	duodenogastric reflux	28.2	NTS PYY SCT SST
7	type 1 diabetes mellitus 15	10.4	GCG INS
8	acute insulin response	10.3	GCG INS
9	pancreatoblastoma	10.3	NTS SST
10	prediabetes syndrome	10.2	GCG INS
11	duodenal somatostatinoma	10.2	INS SST
12	postural hypotension	10.2	INS SST
13	hyperproinsulinemia	10.2	INS SCT
14	hypoglycemia	10.2
15	hyperpituitarism	10.2	INS SST
16	somatostatinoma	10.2	INS SST
17	pancreatic gastrinoma	10.2	SCT SST
18	glucagonoma	10.1	SCT SST
19	islet cell tumor	10.1	INS SST
20	angiodysplasia	10.1	SCT SST
21	pituitary-dependent cushing's disease	10.1	INS SST
22	glucose intolerance	10.1	GCG INS
23	duodenal gastrinoma	10.1	SCT SST
24	pituitary gland disease	10.1	INS SST
25	steatorrhea	10.0	SCT SST
26	esophagitis	10.0
27	diarrhea	10.0
28	cell type benign neoplasm	10.0	INS SST
29	gallbladder disease	10.0	INS SST
30	gastric cancer	10.0
31	peptic ulcer disease	10.0
32	acromegaly	9.9	INS SST
33	serotonin syndrome	9.9	PYY SST
34	duodenitis	9.9
35	congenital microgastria	9.9
36	hyperthyroidism	9.9	INS SST
37	vipoma	9.8	NTS SCT SST
38	zollinger-ellison syndrome	9.8	NTS SCT SST
39	schizophrenia	9.7
40	tracheoesophageal fistula with or without esophageal atresia	9.7
41	charge syndrome	9.7
42	angina pectoris	9.7
43	liver cirrhosis	9.7
44	esophageal atresia	9.7
45	microinvasive gastric cancer	9.7
46	gastroenteritis	9.7
47	pancreatitis	9.7
48	gastroduodenitis	9.7
49	acute pancreatitis	9.7	SCT SST
50	endocrine gland cancer	9.7	GCG SCT SST

Graphical network of the top 20 diseases related to Dumping Syndrome:

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Symptoms & Phenotypes for Dumping Syndrome

UMLS symptoms related to Dumping Syndrome:

constipation, pain, postoperative, vomiting following gastrointestinal surgery, postoperative nausea and vomiting

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Drugs & Therapeutics for Dumping Syndrome

Drugs for Dumping Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

lanreotide

Approved

Phase 4,Phase 2

108736-35-2

Somatostatin

Approved, Investigational

Phase 4,Phase 2,Not Applicable

38916-34-6, 51110-01-1

53481605

Lactitol

Investigational

Phase 4

585-86-4

3871

Synonyms:

(2S,3R,4R,5R)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}hexane-1,2,3,5,6-pentol

4-O-a-D-Glucopyranosyl-D-glucitol

4-O-alpha-delta-Glucopyranosyl-delta-glucitol

4-O-alpha-D-Glucopyranosyl-D-glucitol

4-O-α-D-glucopyranosyl-D-glucitol

a-D-GLC-(1->4)-D-GLC-ol

a-D-GLCP-(1->4)-D-GLC-ol

a-D-Glucosyl-(1->4)-D-glucitol

alpha-D-GLC-(1->4)-D-GLC-ol

alpha-D-GLCP-(1->4)-D-GLC-ol

alpha-D-Glucosyl-(1->4)-D-glucitol

Amalti syrup

Amalty MR 100

D-4-O-alpha-D-Glucopyranosylglucitol

delta-4-O-alpha-delta-Glucopyranosylglucitol

delta-Maltitol

D-Maltitol

Malbit

Malti MR

Maltisorb

Maltit

α-D-GLC-(1->4)-D-GLC-ol

α-D-GLCP-(1->4)-D-GLC-ol

α-D-glucosyl-(1->4)-D-glucitol

Angiopeptin

Phase 4,Phase 2

Hormone Antagonists

Phase 4,Phase 2,Not Applicable

Hormones

Phase 4,Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2,Not Applicable

Pharmaceutical Solutions

Phase 2

Loperamide

Approved

Not Applicable

53179-11-6

3955

Synonyms:

2-methoxyethyl1-methylethyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

34552-83-5 (mono-hydrochloride)

4-(4-Chlorophenyl)-N,N-dimethyl-.alpha.,.alpha.-diphenyl-4-hydroxy-1-piperidinebutanamide

4-(4-Chlorophenyl)-N,N-dimethyl-alpha,alpha-diphenyl-4-hydroxy-1-piperidinebutanamide

4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide

5-21-02-00379 (Beilstein Handbook Reference)

53179-11-6

AB00053697

AC1L1H38

AKOS000573892

apo-Loperamide

Apo-Loperamide

BAS 01889668

Bio1_000082

Bio1_000571

Bio1_001060

Bio2_000101

Bio2_000581

BPBio1_000274

BRD-K61250553-001-02-9

BRD-K61250553-003-05-8

BRN 1558273

BSPBio_000248

BSPBio_001381

BSPBio_002769

C07080

C29H33ClN2O2

CAS-34552-83-5

CBiol_001796

CHEBI:162259

CHEBI:6532

CHEMBL841

CID3955

D08144

DB00836

Diamide (TN)

Diarr-Eze

DivK1c_000215

EINECS 258-416-5

HMS1791F03

HMS1989F03

HMS2089C13

Hydrochloride, loperamide

IDI1_000215

IDI1_033851

Imodium

Imodium a-D

Imodium a-D caplets

Imodium A-D Caplets

Ioperamide

Kaopectate II

KBio1_000215

KBio2_000101

KBio2_000854

KBio2_002669

KBio2_003422

KBio2_005237

KBio2_005990

KBio3_000201

KBio3_000202

KBio3_001989

KBioGR_000101

KBioGR_001685

KBioSS_000101

KBioSS_000854

L000709

Lopac0_000708

Lopac-L-4762

Loperacap

Loperamid

Loperamida

Loperamida [INN-Spanish]

loperamide

Lopéramide

Loperamide (INN)

Loperamide [INN:BAN]

Loperamide hydrochloride

Loperamide monohydrochloride

Loperamide Monohydrochloride

Loperamidum

Loperamidum [INN-Latin]

LS-114352

Maalox anti-diarrheal

Maalox Anti-Diarrheal

MolPort-001-969-016

Monohydrochloride, loperamide

NCGC00015608-01

NCGC00015608-08

NCGC00016828-01

NCGC00024818-01

NCGC00024818-02

NCGC00024818-03

NCGC00024818-04

NCGC00024818-05

nchembio.559-comp8

nchembio.79-comp7

NINDS_000215

Nu-loperamide

Nu-Loperamide

Oprea1_109220

Pepto Diarrhea Control

PMS-Loperamide

Prestwick0_000144

Prestwick1_000144

Prestwick2_000144

Prestwick3_000144

R-18553

rho-Loperamide

Rho-Loperamide

SPBio_001816

SPBio_002187

Spectrum_000374

Spectrum2_001738

Spectrum3_001015

Spectrum4_001143

Spectrum5_001374

ST095179

Tocris-0840

UNII-6X9OC3H4II

Empagliflozin

Approved

Not Applicable

864070-44-0

Rifaximin

Approved, Investigational

Not Applicable

80621-81-4

6436173

Synonyms:

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate

4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV

80621-81-4

88747-56-2

AC-19112

alpha-0817185

Bio-0556

BRN 3584528

C43H51N3O11

CHEMBL1617

D02554

DB01220

Fatroximin

Flonorm

L 105

L 105 (Ansamacrolide antibiotic)

L 105SV

Lormyx

LS-178059

LS-64147

Lumenax

MLS000759430

Normix

Redactiv

RedActiv

Rifacol

Rifamixin

Rifamycin L 105

Rifamycin L 105SV

Rifaxidin

Rifaximin

Rifaximin (USAN/INN)

Rifaximin [USAN:INN]

Rifaximina

Rifaximina [Spanish]

Rifaximine

Rifaximine [French]

Rifaximinum

Rifaximinum [Latin]

Rifaximinun

Rifaxin

Ritacol

S1790_Selleck

SMR000466324

Spiraxin

UNII-L36O5T016N

Xifaxan

Xifaxan, Rifacol, Fatroximin, Rifaximin

Xifaxsan

Xifaxsan (TN)

Narcotics

Dipeptidyl-Peptidase IV Inhibitors

Not Applicable

HIV Protease Inhibitors

Not Applicable

Hypoglycemic Agents

Not Applicable

Incretins

Not Applicable

protease inhibitors

Not Applicable

Sitagliptin Phosphate

Not Applicable

Antidiarrheals

Not Applicable

Gastrointestinal Agents

Not Applicable

Antirheumatic Agents

Not Applicable

insulin

Not Applicable

Insulin, Globin Zinc

Not Applicable

Interleukin 1 Receptor Antagonist Protein

Not Applicable

Anti-Bacterial Agents

Not Applicable

Antibiotics, Antitubercular

Not Applicable

Anti-Infective Agents

Not Applicable

Nucleic Acid Synthesis Inhibitors

Not Applicable

glucagon

Not Applicable

Glucagon-Like Peptide 1

Not Applicable

Interventional clinical trials:

(show all 27)

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of the Dumping Syndrome With Lanreotide Autogel®	Unknown status	NCT00543179	Phase 4	Somatuline (Lanreotide Autogel®)
2	Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study.	Recruiting	NCT01794793	Phase 4	Pasireotide
3	Impact of the Techniques for Intrathoracic Esophagogastric Anastomosis on Outcome in Ivor-Lewis Oesophagectomy	Unknown status	NCT01242124	Phase 2, Phase 3
4	Comparison of Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy	Recruiting	NCT02595086	Phase 3
5	Randomized Controlled Trials Comparing Clinical Outcomes of 3D Versus 2D Laparoscopic Surgery for Gastric Cancer	Active, not recruiting	NCT02327481	Phase 3
6	SOMATULINE Autogel 90 mg IN DUMPING SYNDROME	Unknown status	NCT01923649	Phase 2	Lanreotide 90 mg slow release formulation;Placebo
7	Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome	Completed	NCT01895296	Phase 2	Pasireotide;Placebo
8	Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome	Completed	NCT01637272	Phase 2	SOM230
9	Evaluation of Single Ascending Doses of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia	Active, not recruiting	NCT02996812	Phase 1	Exendin (9-39)
10	Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients	Unknown status	NCT00873405	Not Applicable
11	A Study Comparing Billroth II With Roux-en-Y Reconstruction for Gastric Cancer	Unknown status	NCT01257711	Not Applicable
12	Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide	Completed	NCT00802971	Not Applicable
13	Chronic Marginal Ulcers After Gastric Bypass	Completed	NCT01041079
14	Treatment of Diabetes After Gastric Bypass With Sitagliptin	Completed	NCT01512797	Not Applicable	Sitagliptin phosphate
15	Omega Loop Versus Roux-en-Y Gastric Bypass	Completed	NCT02139813	Not Applicable
16	Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity	Recruiting	NCT02891330	Not Applicable
17	Dumping Syndrome After Operation of Esophageal Atresia Type III	Recruiting	NCT02525705	Not Applicable
18	Comparisons Between Isoperistaltic and Antiperistaltic Gastrojejunostomy in Laparoscopic Distal Gastrectomy	Recruiting	NCT02837874	Not Applicable
19	Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study	Recruiting	NCT03200782	Not Applicable	Empagliflozin;Anakinra
20	Metabolic Consequences of Gastrointestinal Surgery	Recruiting	NCT02836353	Not Applicable	Somatostatin;Rifaximin
21	Laparoscopic Versus Open Gastrectomy for Gastric Cancer	Recruiting	NCT02248519	Not Applicable
22	Routine Post-Operative Supplemental Nutrition	Active, not recruiting	NCT02297607	Not Applicable
23	Role and Mechanisms of Obesity Surgery - Physical Activity and Other Predictors of Hospital Stay, Recovery and Complications After Obesity Surgery	Active, not recruiting	NCT01998815
24	Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study	Active, not recruiting	NCT01778738	Not Applicable
25	Gastrectomy, Eating Behaviour and GLP-1	Enrolling by invitation	NCT02971631	Not Applicable
26	Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans	Enrolling by invitation	NCT02710370
27	Assessment of Gastric Emptying Speed in Patients Who Experience Diarrhea Following a Trigger Meal	Withdrawn	NCT01114113	Not Applicable	pancelipase/placebo

Search NIH Clinical Center for Dumping Syndrome

Cochrane evidence based reviews: dumping syndrome

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Genetic Tests for Dumping Syndrome

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Anatomical Context for Dumping Syndrome

MalaCards organs/tissues related to Dumping Syndrome:

⁴¹

Small Intestine, Testes, Liver, Brain

Sources

Publications for Dumping Syndrome

Articles related to Dumping Syndrome:

(show top 50) (show all 368)

#	Title	Authors	Year
1	Safety and efficacy of pasireotide in dumping syndrome-results from a phase 2, multicentre study. ( 29696671 )	Tack J....Van Beek A.P.	2018
2	Post-Fundoplication Dumping Syndrome: A Frequent &quot;Rare&quot; Complication. ( 29379815 )	Kataria R....Schey R.	2018
3	Severe Dumping Syndrome in a 6-year-old Girl with Congenital Microgastria Treated by Hunt-Lawrence Pouch. ( 28361011 )	Filisetti C....Riccipetitoni G.	2017
4	Effectiveness of sitagliptin in a patient with late dumping syndrome after total gastrectomy. ( 29208515 )	Kurihara K....Hosoi M.	2017
5	A case report: Liraglutide as a novel treatment option in late dumping syndrome. ( 28328816 )	Chiappetta S....Stier C.	2017
6	Late Dumping Syndrome in a 17-Year-Old Female With Charge Syndrome. ( 29205658 )	Morgan A....Blake K.	2017
7	Pregnancy and Dumping Syndrome post-bariatric surgery: a case report. ( 28473681 )	Edawati D.E....Harris N.S.	2017
8	Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management. ( 27749997 )	Van Beek A.P....Tack J.	2017
9	The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life. ( 28624531 )	Emous M....Van Beek A.P.	2017
10	Incretin Kinetics Before and After Miglitol in Japanese Patients With Late Dumping Syndrome. ( 28912925 )	Amagai M....Terauchi Y.	2017
11	Pasireotide and octreotide in the treatment of severe late dumping syndrome. ( 29026555 )	Mohammadi A....Grossman A.B.	2017
12	Experience with FreeStyle Libre Flash glucose monitoring system in management of refractory dumping syndrome in pregnancy shortly after bariatric surgery. ( 29302329 )	Novodvorsky P....Munir A.	2017
13	Dumping Syndrome ( 29261889 )	Hui C....Bauza G.J.	2017
14	Risk of Dumping Syndrome after Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: Early Results of a Multicentre Prospective Study. ( 27242898 )	Ramadan M....Nocca D.	2016
15	Dumping syndrome after esophagectomy: a systematic review of the literature. ( 27859950 )	Boshier P.R....Hanna G.B.	2016
16	Specific Features of Dumping Syndrome after Various Types of Gastrectomy as Assessed by a Newly Developed Integrated Questionnaire, the PGSAS-45. ( 26682541 )	Tanizawa Y....Nakada K.	2016
17	Durable Flap-Valve Mitigation of Duodenogastric Reflux, A Remnant GastritisA and Dumping Syndrome Following Billroth I Reconstruction. ( 26666548 )	Hoya Y....Yanaga K.	2016
18	PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENTOF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERY. ( 27683791 )	Chaves Y.D....Destefani A.C.	2016
19	Concurrent Therapy with a Low-carbohydrate Diet and Miglitol Remarkably Improved the Postprandial Blood Glucose and Insulin Levels in a Patient with Reactive Hypoglycemia due to Late Dumping Syndrome. ( 27150868 )	Hirose S....Tamori Y.	2016
20	Endoluminal Revision (OverStitch (TM) , Apollo Endosurgery) of the Dilated Gastroenterostomy in Patients with Late Dumping Syndrome After Proximal Roux-en-Y Gastric Bypass. ( 27318467 )	Stier C....Chiappetta S.	2016
21	Early dumping syndrome is not a complication but a desirable feature of Roux-en-Y gastric bypass surgery. ( 27487971 )	Laurenius A....EngstrAPm M.	2016
22	Temporary dumping syndrome after gastric peroral endoscopic myotomy: should we control the glycemia? ( 26800191 )	Louazon T....Pioche M.	2016
23	Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment. ( 26396002 )	Berg P....McCallum R.	2015
24	Dumping Syndrome due to the Misplacement of the Gastrostomy Feeding Tube. ( 26424320 )	Shimoda M....Tanaka Y.	2015
25	Improvement of dumping syndrome and oversecretion of glucose-dependent insulinotropic polypeptide following a switch from olanzapine to quetiapine in a patient with schizophrenia. ( 25835510 )	Watanabe A....Someya T.	2015
26	A possible difference in the mechanism for postprandial hypoglycemia associated with dumping syndrome between patients with and without type 2 diabetes. ( 26321136 )	Hamasaki H....Yanai H.	2015
27	Conversion to Modified Duodenal Switch for Relieving Intractable Dumping Syndrome and Constipation After Laparoscopic Roux-en-Y Gastric Bypass. ( 25701270 )	Huang C.K....Chang P.C.	2015
28	Verification of glycemic profiles using continuous glucose monitoring: cases with steroid use, liver cirrhosis, enteral nutrition, or late dumping syndrome. ( 25817276 )	Kishimoto M....Noda M.	2015
29	Erratum: Dumping syndrome following nissen fundoplication in an adult patient diagnosed by continuous online 13C/12C monitoring of (13)C-Octanoic acid breath test &quot;a case report&quot;. ( 25956481 )	Mizrahi M....Lysy J.	2015
30	Laparoscopic Conversion to Loop Duodenojejunal Bypass with Sleeve Gastrectomy for Intractable Dumping Syndrome After Roux-en-Y Gastric Bypass-Two Case Reports. ( 25708238 )	Huang C.K....Chang P.C.	2015
31	Dumping syndrome with severe hipoglycemia after Nissen fundoplication in adults. Case report and literature review. ( 25132186 )	RoldA!n BaA+os S....Parrilla Paricio P.	2014
32	A pilot study of the effects of the somatostatin analog pasireotide in postoperative dumping syndrome. ( 24750284 )	Deloose E....Tack J.	2014
33	Complications of bariatric surgery: dumping syndrome, reflux and vitamin deficiencies. ( 25194187 )	Tack J....Deloose E.	2014
34	Treatment with acarbose in severe hypoglycaemia due to late dumping syndrome. ( 25117397 )	Wang C....Li M.	2013
35	Diazoxide for the treatment of hypoglycaemic dumping syndrome. ( 22147922 )	Thondam S.K....Gill G.V.	2013
36	Octreotide improves early dumping syndrome potentially through incretins: a case report. ( 23708181 )	Sato D....Maegawa H.	2013
37	The role of dumping syndrome in weight loss after gastric bypass surgery. ( 23233009 )	Banerjee A....Needleman B.J.	2013
38	Continuous glucose monitoring for suspected dumping syndrome in infants after Nissen fundoplication. ( 24330287 )	Ueda K....Hata D.	2013
39	Seven-day subcutaneous continuous glucose monitoring demonstrates that treatment with acarbose attenuates late dumping syndrome in a woman with gastrectomy for gastric cancer. ( 23146372 )	Buscemi S....Costanzo M.	2013
40	Dumping syndrome following gastric bypass: validation of the dumping symptom rating scale. ( 23315151 )	Laurenius A....Karlsson J.	2013
41	Laparoscopic conversion of laparoscopic Roux-en-Y gastric bypass to laparoscopic sleeve gastrectomy for intractable dumping syndrome and excessive weight loss. ( 23369599 )	Zurita Mv L.C....Hong D.	2013
42	Early dumping syndrome and reflux esophagitis prevention with pouch reconstruction. ( 21492874 )	Dikic S....Pazin V.	2012
43	Symptoms suggestive of dumping syndrome after provocation in patients after laparoscopic sleeve gastrectomy. ( 21647622 )	Tzovaras G....Koukoulis G.	2012
44	Successful treatment of reactive hypoglycemia secondary to late dumping syndrome using miglitol. ( 22989830 )	Fujita Y....Shimomura I.	2012
45	Medical complications of bariatric surgery: focus on malabsorption and dumping syndrome. ( 22722436 )	Hammer H.F.	2012
46	Dumping syndrome, a cause of acquired glycogenic hepatopathy. ( 21338321 )	Resnick J.M....Fish D.L.	2011
47	Dumping syndrome following nissen fundoplication in an adult patient diagnosed by continuous online 13C/12C monitoring of A^A^C-Octanoic acid breath test &quot;a case report&quot;. ( 21929798 )	Mizrahi M....Lysy J.	2011
48	Safety and efficacy of high-dose acarbose treatment for dumping syndrome. ( 21694549 )	De Cunto A....Ventura A.	2011
49	Dumping syndrome: an unusual cause of severe hyperinsulinemic hypoglycemia in neurologically impaired children with gastrostomy. ( 21311431 )	Bizzarri C....Cappa M.	2011
50	Dumping syndrome after esophageal atresia repair without antireflux surgery. ( 20385264 )	Michaud L....Gottrand F.	2010

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Genes for Dumping Syndrome

Genes related to Dumping Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SST	Somatostatin	Protein Coding	31.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8103615 1978748 19724252 (more) 8359570 8317033 19264574 7933883
2	NTS	Neurotensin	Protein Coding	29.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9403815
3	PYY	Peptide YY	Protein Coding	27.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1415124
4	GCG	Glucagon	Protein Coding	25.19	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16416173 9200302 11575444
5	INS	Insulin	Protein Coding	23.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	GIP	Gastric Inhibitory Polypeptide	Protein Coding	22.77	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	SCT	Secretin	Protein Coding	20.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Dumping Syndrome

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Expression for Dumping Syndrome

Search GEO for disease gene expression data for Dumping Syndrome.

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Pathways for Dumping Syndrome

Pathways related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁶ Show member pathways GPCR downstream signaling ⁶⁶ Signal Transduction ⁶⁶	13.4	GCG GIP INS NTS PYY SCT
2	Peptide ligand-binding receptors ⁶⁶ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁶ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁶ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁶ G alpha (i) signalling events ⁶⁶ GPCR ligand binding ⁶⁶ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁷ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁶ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁶ Vasopressin-like receptors ⁶⁶	12.37	GCG GIP NTS PYY SCT SST
3	Presynaptic function of Kainate receptors ⁶⁶ Show member pathways Activation of Ca-permeable Kainate Receptor ⁶⁶ Activation of Kainate Receptors upon glutamate binding ⁶⁶ Activation of Na-permeable Kainate Receptors ⁶⁶ Calcitonin-like ligand receptors ⁶⁶ Class B/2 (Secretin family receptors) ⁶⁶ G beta-gamma signalling through PLC beta ⁶⁶ Glucagon-type ligand receptors ⁶⁶ G-Protein Signaling through Tubby Protein ⁶⁴ Ionotropic activity of Kainate Receptors ⁶⁶	11.9	GCG GIP SCT
4	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Insulin processing ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶	11.69	GCG GIP INS
5	G alpha (s) signalling events ⁶⁶	11.3	GCG GIP SCT
6	Incretin synthesis, secretion, and inactivation ⁶⁶ Show member pathways Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ⁶⁶ Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) ⁶⁶	11.15	GCG GIP
7	FOXA1 transcription factor network ¹ Show member pathways FOXA transcription factor networks ¹	11.03	GCG INS

Sources

GO Terms for Dumping Syndrome

Cellular components related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.43	GCG GIP INS
2	extracellular space	GO:0005615	9.43	GCG GIP INS PYY SCT SST
3	secretory granule lumen	GO:0034774	9.33	GCG GIP INS
4	transport vesicle	GO:0030133	9.32	INS NTS
5	extracellular region	GO:0005576	9.17	GCG GIP INS NTS PYY SCT

Biological processes related to Dumping Syndrome according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:0007267	9.61	INS PYY SST
2	G-protein coupled receptor signaling pathway	GO:0007186	9.5	GCG GIP INS NTS PYY SCT
3	response to glucose	GO:0009749	9.49	GIP INS
4	regulation of insulin secretion	GO:0050796	9.48	GCG GIP
5	response to nutrient levels	GO:0031667	9.46	GIP INS
6	feeding behavior	GO:0007631	9.4	GCG PYY
7	response to amino acid	GO:0043200	9.37	GIP SST
8	response to starvation	GO:0042594	9.32	GCG GIP
9	positive regulation of cAMP-mediated signaling	GO:0043950	9.26	GIP SCT
10	regulation of signaling receptor activity	GO:0010469	9.17	GCG GIP INS NTS PYY SCT
11	response to acidic pH	GO:0010447	9.16	GIP SST

Molecular functions related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G-protein coupled receptor binding	GO:0001664	9.16	PYY SCT
2	hormone activity	GO:0005179	9.1	GCG GIP INS PYY SCT SST
3	neuropeptide hormone activity	GO:0005184	8.96	NTS PYY

Sources

Sources for Dumping Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia