MCID: DMP001
MIFTS: 46

Dumping Syndrome

Categories: Gastrointestinal diseases

Aliases & Classifications for Dumping Syndrome

MalaCards integrated aliases for Dumping Syndrome:

Name: Dumping Syndrome 12 56 45 15 17 74
Dumping 56 74
Postgastrectomy Syndromes 74
Dumping Syndrome 12
Jejunal Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14495
MeSH 45 D004377
NCIt 51 C2994
SNOMED-CT 69 80193009
ICD10 34 K91.1

Summaries for Dumping Syndrome

MalaCards based summary : Dumping Syndrome, also known as dumping, is related to hyperinsulinemic hypoglycemia and duodenal ulcer, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Dumping Syndrome is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and Aldosterone synthesis and secretion. The drugs Somatostatin and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pituitary.

Wikipedia : 77 Dumping syndrome occurs when food, especially sugar, moves too quickly from the stomach to the... more...

Related Diseases for Dumping Syndrome

Diseases related to Dumping Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia 30.0 INS SST
2 duodenal ulcer 29.8 INS SCT SST
3 gastroesophageal reflux 29.6 GCG NTS PYY
4 constipation 29.5 NTS PYY SST
5 insulinoma 29.2 GCG INS SCT SST
6 duodenogastric reflux 29.1 NTS PYY SCT SST
7 degos 'en cocarde' erythrokeratoderma 10.4
8 hypoglycemia 10.4
9 type 1 diabetes mellitus 15 10.2 GCG INS
10 hyperinsulinemic hypoglycemia, familial, 7 10.2 GCG INS
11 maturity-onset diabetes of the young, type 9 10.2 GCG INS
12 hirata disease 10.2 GCG INS
13 acute insulin response 10.2 GCG INS
14 pancreatoblastoma 10.2 NTS SST
15 diarrhea 10.1
16 prediabetes syndrome 10.1 GCG INS
17 space motion sickness 10.1 NTS SCT
18 duodenal somatostatinoma 10.1 INS SST
19 somatostatinoma 10.1 INS SST
20 pancreatic endocrine carcinoma 10.1 INS SST
21 hyperproinsulinemia 10.1 INS SCT
22 hyperpituitarism 10.1 INS SST
23 functional gastric disease 10.1 INS SST
24 smith-magenis syndrome 10.1
25 gastric cancer 10.1
26 peptic ulcer disease 10.1
27 glucagonoma 10.1 SCT SST
28 islet cell tumor 10.1 INS SST
29 angiodysplasia 10.1 SCT SST
30 pituitary-dependent cushing's disease 10.1 INS SST
31 maturity-onset diabetes of the young, type 7 10.1 INS SCT
32 duodenal gastrinoma 10.1 SCT SST
33 endocrine organ benign neoplasm 10.1 INS SST
34 steatorrhea 10.0 SCT SST
35 thyroid gland disease 10.0 INS SST
36 pituitary gland disease 10.0 INS SST
37 cell type benign neoplasm 10.0 INS SST
38 acromegaly 10.0 INS SST
39 small intestine cancer 10.0 SCT SST
40 hyperthyroidism 10.0 INS SST
41 peptic esophagitis 10.0
42 congenital microgastria 10.0
43 pneumatosis cystoides intestinalis 10.0 PYY SST
44 microvascular complications of diabetes 1 10.0 INS SST
45 serotonin syndrome 10.0 PYY SST
46 insulin-like growth factor i 10.0 INS SST
47 endocrine gland cancer 10.0 GCG SST
48 neuroendocrine tumor 9.9 NTS SST
49 acute pancreatitis 9.9 SCT SST
50 pancreatic cystadenoma 9.9 GCG INS SST

Graphical network of the top 20 diseases related to Dumping Syndrome:



Diseases related to Dumping Syndrome

Symptoms & Phenotypes for Dumping Syndrome

UMLS symptoms related to Dumping Syndrome:


constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery

Drugs & Therapeutics for Dumping Syndrome

Drugs for Dumping Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 4,Phase 2,Not Applicable 38916-34-6, 51110-01-1 53481605
2
lanreotide Approved Phase 4,Phase 2 108736-35-2
3
Pasireotide Approved Phase 4,Phase 2 396091-73-9 9941444
4
Lactitol Investigational Phase 4 585-88-6, 585-86-4 493591
5 Hormone Antagonists Phase 4,Phase 2,Not Applicable
6 Angiopeptin Phase 4,Phase 2
7 Hormones Phase 4,Phase 2,Not Applicable
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
9 Pharmaceutical Solutions Phase 2
10
Empagliflozin Approved Not Applicable 864070-44-0
11
Loperamide Approved Not Applicable 53179-11-6 3955
12
Glucagon Approved Not Applicable 16941-32-5
13
Sulfasalazine Approved 599-79-1 5359476 5353980
14
Octreotide Approved, Investigational 83150-76-9 6400441 383414
15
Acetaminophen Approved 103-90-2 1983
16
Rifaximin Approved, Investigational Not Applicable 80621-81-4 46783403 6436173
17
Imidacloprid Vet_approved Not Applicable 105827-78-9 86418
18 Antirheumatic Agents Not Applicable
19 Sodium-Glucose Transporter 2 Inhibitors Not Applicable
20 insulin Not Applicable
21 Hypoglycemic Agents Not Applicable
22 Insulin, Globin Zinc Not Applicable
23 Interleukin 1 Receptor Antagonist Protein Not Applicable
24 Narcotics
25
protease inhibitors Not Applicable
26 HIV Protease Inhibitors Not Applicable
27 Sitagliptin Phosphate Not Applicable
28 Dipeptidyl-Peptidase IV Inhibitors Not Applicable
29 Incretins Not Applicable
30 Antidiarrheals Not Applicable
31 Gastrointestinal Agents Not Applicable
32 Glucagon-Like Peptide 1 Not Applicable
33 Peripheral Nervous System Agents
34 Anti-Infective Agents ,Not Applicable
35 Nutrients
36 Antineoplastic Agents, Hormonal
37 Antipyretics
38 Anti-Inflammatory Agents
39 Analgesics, Non-Narcotic
40 Analgesics
41 Anti-Inflammatory Agents, Non-Steroidal
42 Antibiotics, Antitubercular Not Applicable
43 Anti-Bacterial Agents Not Applicable

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
2 Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study. Recruiting NCT01794793 Phase 4 Pasireotide
3 Impact of the Techniques for Intrathoracic Esophagogastric Anastomosis on Outcome in Ivor-Lewis Oesophagectomy Unknown status NCT01242124 Phase 2, Phase 3
4 Comparison of Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy Recruiting NCT02595086 Phase 3
5 Randomized Controlled Trials Comparing Clinical Outcomes of 3D Versus 2D Laparoscopic Surgery for Gastric Cancer Active, not recruiting NCT02327481 Phase 3
6 Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
7 SOMATULINE Autogel 90 mg IN DUMPING SYNDROME Unknown status NCT01923649 Phase 2 Lanreotide 90 mg slow release formulation;Placebo
8 Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome Completed NCT01895296 Phase 2 Pasireotide;Placebo
9 Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome Completed NCT01637272 Phase 2 SOM230
10 Evaluation of Single Ascending Doses of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia Unknown status NCT02996812 Phase 1 Exendin (9-39)
11 Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients Unknown status NCT00873405 Not Applicable
12 A Study Comparing Billroth II With Roux-en-Y Reconstruction for Gastric Cancer Unknown status NCT01257711 Not Applicable
13 Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study Completed NCT03200782 Not Applicable Empagliflozin;Anakinra
14 Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide Completed NCT00802971 Not Applicable
15 Chronic Marginal Ulcers After Gastric Bypass Completed NCT01041079
16 Routine Post-Operative Supplemental Nutrition Completed NCT02297607 Not Applicable
17 Treatment of Diabetes After Gastric Bypass With Sitagliptin Completed NCT01512797 Not Applicable Sitagliptin phosphate
18 Omega Loop Versus Roux-en-Y Gastric Bypass Completed NCT02139813 Not Applicable
19 Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity Recruiting NCT02891330 Not Applicable
20 Dumping Syndrome After Operation of Esophageal Atresia Type III Recruiting NCT02525705 Not Applicable
21 Dumping Syndrome and Quality of Life After Vagus Nerve-preserving Distal Gastrectomy Recruiting NCT03880747
22 Comparisons Between Isoperistaltic and Antiperistaltic Gastrojejunostomy in Laparoscopic Distal Gastrectomy Recruiting NCT02837874 Not Applicable
23 Single-anastomosis Duodeno Ileal Bypass (SADI) Versus Roux-en-Y Gastric Bypass Recruiting NCT03610256 Not Applicable
24 Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study Active, not recruiting NCT01778738 Not Applicable
25 Laparoscopic Versus Open Gastrectomy for Gastric Cancer Active, not recruiting NCT02248519 Not Applicable
26 Gastrectomy, Eating Behaviour and GLP-1 Enrolling by invitation NCT02971631 Not Applicable
27 Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery Enrolling by invitation NCT03734627 Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine
28 Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans Enrolling by invitation NCT02710370
29 Role and Mechanisms of Obesity Surgery - Physical Activity and Other Predictors of Hospital Stay, Recovery and Complications After Obesity Surgery Suspended NCT01998815
30 Metabolic Consequences of Gastrointestinal Surgery Terminated NCT02836353 Not Applicable Somatostatin;Rifaximin
31 Assessment of Gastric Emptying Speed in Patients Who Experience Diarrhea Following a Trigger Meal Withdrawn NCT01114113 Not Applicable pancelipase/placebo
32 Neujia Anastomosis for Treatment of Obesity and Type II Diabetes Withdrawn NCT03675074 Not Applicable

Search NIH Clinical Center for Dumping Syndrome

Cochrane evidence based reviews: dumping syndrome

Genetic Tests for Dumping Syndrome

Anatomical Context for Dumping Syndrome

MalaCards organs/tissues related to Dumping Syndrome:

42
Small Intestine, Testes, Pituitary, Pancreas, Lung, Breast, Whole Blood

Publications for Dumping Syndrome

Articles related to Dumping Syndrome:

(show top 50) (show all 918)
# Title Authors Year
1
Prevalence of Dumping Syndrome After Laparoscopic Sleeve Gastrectomy and Comparison with Laparoscopic Roux-en-Y Gastric Bypass. ( 30635813 )
2019
2
A Real-World, Insurance-Based Algorithm Using the Two-Fold Running Suture Technique for Transoral Outlet Reduction for Weight Regain and Dumping Syndrome After Roux-En-Y Gastric Bypass. ( 30937874 )
2019
3
Heterogeneity in the Definition and Clinical Characteristics of Dumping Syndrome: a Review of the Literature. ( 30941693 )
2019
4
Prevalence and pathophysiology of early dumping in patients after primary Roux-en-Y gastric bypass during a mixed-meal tolerance test. ( 30446401 )
2019
5
Prevalence and pathophysiology of early dumping in patients after primary Roux-en-Y gastric bypass during a mixed-meal tolerance test. ( 30503167 )
2019
6
Detection of waste dumping locations in landfill using multi-temporal Landsat thermal images. ( 30632930 )
2019
7
Distribution of butyltins at dredged material dumping sites around the coast of China and the potential ecological risk. ( 30660299 )
2019
8
Age of both parents influences reproduction and egg dumping behavior in Drosophila melanogaster. ( 30753690 )
2019
9
Patient Dumping. ( 30801292 )
2019
10
Ocean Dumping of Containerized DDT Waste Was a Sloppy Process. ( 30829032 )
2019
11
A novel initiative to counteract illegal dumping in rural areas of Valladolid Province (Spain). ( 30854620 )
2019
12
Pulsed output generation in a diode-pumped cesium vapor laser using the cavity dumping technique. ( 30874638 )
2019
13
Fractionation and risk assessment of metals in sediments of an ocean dumping site. ( 30955729 )
2019
14
Potential of fungi isolated from the dumping sites mangrove rhizosphere soil to degrade polythene. ( 30926843 )
2019
15
Effectiveness of sitagliptin in a patient with late dumping syndrome after total gastrectomy. ( 29208515 )
2018
16
Post-Fundoplication Dumping Syndrome: A Frequent "Rare" Complication. ( 29379815 )
2018
17
Safety and efficacy of pasireotide in dumping syndrome-results from a phase 2, multicentre study. ( 29696671 )
2018
18
Transient severe distributive shock due to early dumping syndrome: a case report. ( 30208930 )
2018
19
Applications of peptide hormone ligands for the treatment of dumping and short bowel syndrome. ( 30273889 )
2018
20
946  nm Nd:YAG laser with cavity dumping. ( 30004529 )
2018
21
Long-term self-reported symptom prevalence of early and late dumping in a patient population after sleeve gastrectomy, primary, and revisional gastric bypass surgery. ( 29858129 )
2018
22
Europe's biggest research fund cracks down on 'ethics dumping'. ( 29970912 )
2018
23
Mercury contamination in the sludge of drinking water treatment plants dumping into a reservoir in Rio de Janeiro, Brazil. ( 30099710 )
2018
24
Phytoremediation of waste dumping site soil and landfill leachate by using cattail (Typha latifolia). ( 30198835 )
2018
25
Dumping to the abyss: single-use marine litter invading bathyal plains of the Sardinian margin (Tyrrhenian Sea). ( 30301106 )
2018
26
Patient Dumping Is Still a Problem. ( 30358587 )
2018
27
Insight into occurrence, profile and spatial distribution of organochlorine pesticides in soils of solid waste dumping sites of Pakistan: Influence of soil properties and implications for environmental fate. ( 30529619 )
2018
28
Nonmotile Single-Cell Migration as a Random Walk in Nonuniformity: The "Extreme Dumping Limit" for Cell-to-Cell Communications. ( 30595832 )
2018
29
Impact of dredged-material disposal on soft-bottom communities in a recurrent marine dumping area near to Guadalquivir estuary, Spain. ( 29773315 )
2018
30
On the dumping ground genus Scotaena Klug, 1810 (Hymenoptera: Tiphiidae: Thynninae): Phylogeny, taxonomy and geographic distribution. ( 29690290 )
2018
31
Predictors of illegal dumping at charitable collection points. ( 29453014 )
2018
32
Effects of open dumping of MSW on metal contamination of soil, plants, and earthworms in Ranchi, Jharkhand, India. ( 29442190 )
2018
33
Identifying areas under potential risk of illegal construction and demolition waste dumping using GIS tools. ( 29402616 )
2018
34
Deep sea habitats in the chemical warfare dumping areas of the Baltic Sea. ( 29111251 )
2018
35
Improving the monitoring of a dumping site in a dynamic environment. Example of the Octeville site (Bay of Seine, English Channel). ( 29055561 )
2018
36
Assessing the risk of alcohol-induced dose dumping from sustained-release oral dosage forms: in vitro-in silico approach. ( 29043886 )
2018
37
The Effect of Dumping on Weight Loss in Conversion of Failed Restrictive Surgery: a Cross-Sectional Pilot Study. ( 28933032 )
2018
38
Late Dumping Syndrome in a 17-Year-Old Female With Charge Syndrome. ( 29205658 )
2017
39
Severe Dumping Syndrome in a 6-year-old Girl with Congenital Microgastria Treated by Hunt-Lawrence Pouch. ( 28361011 )
2017
40
Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management. ( 27749997 )
2017
41
Dumping syndrome after esophagectomy: a systematic review of the literature. ( 27859950 )
2017
42
A case report: Liraglutide as a novel treatment option in late dumping syndrome. ( 28328816 )
2017
43
Pregnancy and Dumping Syndrome post-bariatric surgery: a case report. ( 28473681 )
2017
44
The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life. ( 28624531 )
2017
45
Incretin Kinetics Before and After Miglitol in Japanese Patients With Late Dumping Syndrome. ( 28912925 )
2017
46
Pasireotide and octreotide in the treatment of severe late dumping syndrome. ( 29026555 )
2017
47
Experience with FreeStyle Libre Flash glucose monitoring system in management of refractory dumping syndrome in pregnancy shortly after bariatric surgery. ( 29302329 )
2017
48
Dumping the information bucket: A qualitative study of clinicians caring for patients with early stage non-small cell lung cancer. ( 28034611 )
2017
49
High peak power cavity dumping semiconductor lasers. ( 28059191 )
2017
50
Traffic accident or dumping? - Striking results of a traffic accident reconstruction. ( 28081791 )
2017

Variations for Dumping Syndrome

Expression for Dumping Syndrome

Search GEO for disease gene expression data for Dumping Syndrome.

Pathways for Dumping Syndrome

Pathways related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 GCG GIP INS NTS PYY SCT
2
Show member pathways
12.47 GCG GIP INS
3
Show member pathways
12.38 GCG GIP NTS PYY SCT SST
4
Show member pathways
11.9 GCG GIP SCT
5
Show member pathways
11.69 GCG GIP INS
6 11.3 GCG GIP SCT
7
Show member pathways
11.15 GCG GIP
8
Show member pathways
11.03 GCG INS

GO Terms for Dumping Syndrome

Cellular components related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 GCG GIP INS
2 extracellular space GO:0005615 9.43 GCG GIP INS PYY SCT SST
3 secretory granule lumen GO:0034774 9.33 GCG GIP INS
4 transport vesicle GO:0030133 9.32 INS NTS
5 extracellular region GO:0005576 9.17 GCG GIP INS NTS PYY SCT

Biological processes related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.5 GCG GIP INS NTS PYY SCT
2 regulation of insulin secretion GO:0050796 9.4 GCG GIP
3 response to amino acid GO:0043200 9.37 GIP SST
4 feeding behavior GO:0007631 9.32 GCG PYY
5 positive regulation of cAMP-mediated signaling GO:0043950 9.26 GIP SCT
6 regulation of signaling receptor activity GO:0010469 9.17 GCG GIP INS NTS PYY SCT
7 response to acidic pH GO:0010447 9.16 GIP SST

Molecular functions related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.16 PYY SCT
2 hormone activity GO:0005179 9.1 GCG GIP INS PYY SCT SST
3 neuropeptide hormone activity GO:0005184 8.96 NTS PYY

Sources for Dumping Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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