Dumping Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DMP001 MIFTS: 46	Dumping Syndrome Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Dumping Syndrome

MalaCards integrated aliases for Dumping Syndrome:

Name: Dumping Syndrome ¹² ⁵⁶ ⁴⁵ ¹⁵ ¹⁷ ⁷⁴

Dumping ⁵⁶ ⁷⁴

Postgastrectomy Syndromes ⁷⁴

Dumping Syndrome ¹²

Jejunal Syndrome ¹²

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the digestive system

Other diseases of the digestive system

Postprocedural disorders of digestive system, not elsewhere classified

Postgastric surgery syndromes

External Ids:

Disease Ontology ¹² DOID:14495

MeSH ⁴⁵ D004377

NCIt ⁵¹ C2994

SNOMED-CT ⁶⁹ 80193009

ICD10 ³⁴ K91.1

EFO ¹⁷ EFO_1001307

UMLS ⁷⁴ C0013288 C0032763 C0221542

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Summaries for Dumping Syndrome

MalaCards based summary : Dumping Syndrome, also known as dumping, is related to hyperinsulinemic hypoglycemia and duodenal ulcer, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Dumping Syndrome is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and Aldosterone synthesis and secretion. The drugs Somatostatin and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pituitary.

Wikipedia : ⁷⁷ Dumping syndrome occurs when food, especially sugar, moves too quickly from the stomach to the... more...

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Related Diseases for Dumping Syndrome

Diseases related to Dumping Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)

#	Related Disease	Score	Top Affiliating Genes
1	hyperinsulinemic hypoglycemia	30.0	INS SST
2	duodenal ulcer	29.8	INS SCT SST
3	gastroesophageal reflux	29.6	GCG NTS PYY
4	constipation	29.5	NTS PYY SST
5	insulinoma	29.2	GCG INS SCT SST
6	duodenogastric reflux	29.1	NTS PYY SCT SST
7	degos 'en cocarde' erythrokeratoderma	10.4
8	hypoglycemia	10.4
9	type 1 diabetes mellitus 15	10.2	GCG INS
10	hyperinsulinemic hypoglycemia, familial, 7	10.2	GCG INS
11	maturity-onset diabetes of the young, type 9	10.2	GCG INS
12	hirata disease	10.2	GCG INS
13	acute insulin response	10.2	GCG INS
14	pancreatoblastoma	10.2	NTS SST
15	diarrhea	10.1
16	prediabetes syndrome	10.1	GCG INS
17	space motion sickness	10.1	NTS SCT
18	duodenal somatostatinoma	10.1	INS SST
19	somatostatinoma	10.1	INS SST
20	pancreatic endocrine carcinoma	10.1	INS SST
21	hyperproinsulinemia	10.1	INS SCT
22	hyperpituitarism	10.1	INS SST
23	functional gastric disease	10.1	INS SST
24	smith-magenis syndrome	10.1
25	gastric cancer	10.1
26	peptic ulcer disease	10.1
27	glucagonoma	10.1	SCT SST
28	islet cell tumor	10.1	INS SST
29	angiodysplasia	10.1	SCT SST
30	pituitary-dependent cushing's disease	10.1	INS SST
31	maturity-onset diabetes of the young, type 7	10.1	INS SCT
32	duodenal gastrinoma	10.1	SCT SST
33	endocrine organ benign neoplasm	10.1	INS SST
34	steatorrhea	10.0	SCT SST
35	thyroid gland disease	10.0	INS SST
36	pituitary gland disease	10.0	INS SST
37	cell type benign neoplasm	10.0	INS SST
38	acromegaly	10.0	INS SST
39	small intestine cancer	10.0	SCT SST
40	hyperthyroidism	10.0	INS SST
41	peptic esophagitis	10.0
42	congenital microgastria	10.0
43	pneumatosis cystoides intestinalis	10.0	PYY SST
44	microvascular complications of diabetes 1	10.0	INS SST
45	serotonin syndrome	10.0	PYY SST
46	insulin-like growth factor i	10.0	INS SST
47	endocrine gland cancer	10.0	GCG SST
48	neuroendocrine tumor	9.9	NTS SST
49	acute pancreatitis	9.9	SCT SST
50	pancreatic cystadenoma	9.9	GCG INS SST

Graphical network of the top 20 diseases related to Dumping Syndrome:

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Symptoms & Phenotypes for Dumping Syndrome

UMLS symptoms related to Dumping Syndrome:

constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery

Sources

Drugs & Therapeutics for Dumping Syndrome

Drugs for Dumping Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Somatostatin

Approved, Investigational

Phase 4,Phase 2,Not Applicable

38916-34-6, 51110-01-1

53481605

lanreotide

Approved

Phase 4,Phase 2

108736-35-2

Pasireotide

Approved

Phase 4,Phase 2

396091-73-9

9941444

Lactitol

Investigational

Phase 4

585-88-6, 585-86-4

493591

Hormone Antagonists

Phase 4,Phase 2,Not Applicable

Angiopeptin

Phase 4,Phase 2

Hormones

Phase 4,Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2,Not Applicable

Pharmaceutical Solutions

Phase 2

Empagliflozin

Approved

Not Applicable

864070-44-0

Loperamide

Approved

Not Applicable

53179-11-6

3955

Glucagon

Approved

Not Applicable

16941-32-5

Sulfasalazine

Approved

599-79-1

5359476 5353980

Octreotide

Approved, Investigational

83150-76-9

6400441 383414

Acetaminophen

Approved

103-90-2

1983

Rifaximin

Approved, Investigational

Not Applicable

80621-81-4

46783403 6436173

Imidacloprid

Vet_approved

Not Applicable

105827-78-9

86418

Antirheumatic Agents

Not Applicable

Sodium-Glucose Transporter 2 Inhibitors

Not Applicable

insulin

Not Applicable

Hypoglycemic Agents

Not Applicable

Insulin, Globin Zinc

Not Applicable

Interleukin 1 Receptor Antagonist Protein

Not Applicable

Narcotics

protease inhibitors

Not Applicable

HIV Protease Inhibitors

Not Applicable

Sitagliptin Phosphate

Not Applicable

Dipeptidyl-Peptidase IV Inhibitors

Not Applicable

Incretins

Not Applicable

Antidiarrheals

Not Applicable

Gastrointestinal Agents

Not Applicable

Glucagon-Like Peptide 1

Not Applicable

Peripheral Nervous System Agents

Anti-Infective Agents

,Not Applicable

Nutrients

Antineoplastic Agents, Hormonal

Antipyretics

Anti-Inflammatory Agents

Analgesics, Non-Narcotic

Analgesics

Anti-Inflammatory Agents, Non-Steroidal

Antibiotics, Antitubercular

Not Applicable

Anti-Bacterial Agents

Not Applicable

Interventional clinical trials:

(show all 32)

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of the Dumping Syndrome With Lanreotide Autogel®	Unknown status	NCT00543179	Phase 4	Somatuline (Lanreotide Autogel®)
2	Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study.	Recruiting	NCT01794793	Phase 4	Pasireotide
3	Impact of the Techniques for Intrathoracic Esophagogastric Anastomosis on Outcome in Ivor-Lewis Oesophagectomy	Unknown status	NCT01242124	Phase 2, Phase 3
4	Comparison of Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy	Recruiting	NCT02595086	Phase 3
5	Randomized Controlled Trials Comparing Clinical Outcomes of 3D Versus 2D Laparoscopic Surgery for Gastric Cancer	Active, not recruiting	NCT02327481	Phase 3
6	Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy	Withdrawn	NCT00622804	Phase 3
7	SOMATULINE Autogel 90 mg IN DUMPING SYNDROME	Unknown status	NCT01923649	Phase 2	Lanreotide 90 mg slow release formulation;Placebo
8	Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome	Completed	NCT01895296	Phase 2	Pasireotide;Placebo
9	Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome	Completed	NCT01637272	Phase 2	SOM230
10	Evaluation of Single Ascending Doses of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia	Unknown status	NCT02996812	Phase 1	Exendin (9-39)
11	Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients	Unknown status	NCT00873405	Not Applicable
12	A Study Comparing Billroth II With Roux-en-Y Reconstruction for Gastric Cancer	Unknown status	NCT01257711	Not Applicable
13	Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study	Completed	NCT03200782	Not Applicable	Empagliflozin;Anakinra
14	Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide	Completed	NCT00802971	Not Applicable
15	Chronic Marginal Ulcers After Gastric Bypass	Completed	NCT01041079
16	Routine Post-Operative Supplemental Nutrition	Completed	NCT02297607	Not Applicable
17	Treatment of Diabetes After Gastric Bypass With Sitagliptin	Completed	NCT01512797	Not Applicable	Sitagliptin phosphate
18	Omega Loop Versus Roux-en-Y Gastric Bypass	Completed	NCT02139813	Not Applicable
19	Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity	Recruiting	NCT02891330	Not Applicable
20	Dumping Syndrome After Operation of Esophageal Atresia Type III	Recruiting	NCT02525705	Not Applicable
21	Dumping Syndrome and Quality of Life After Vagus Nerve-preserving Distal Gastrectomy	Recruiting	NCT03880747
22	Comparisons Between Isoperistaltic and Antiperistaltic Gastrojejunostomy in Laparoscopic Distal Gastrectomy	Recruiting	NCT02837874	Not Applicable
23	Single-anastomosis Duodeno Ileal Bypass (SADI) Versus Roux-en-Y Gastric Bypass	Recruiting	NCT03610256	Not Applicable
24	Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study	Active, not recruiting	NCT01778738	Not Applicable
25	Laparoscopic Versus Open Gastrectomy for Gastric Cancer	Active, not recruiting	NCT02248519	Not Applicable
26	Gastrectomy, Eating Behaviour and GLP-1	Enrolling by invitation	NCT02971631	Not Applicable
27	Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery	Enrolling by invitation	NCT03734627		Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine
28	Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans	Enrolling by invitation	NCT02710370
29	Role and Mechanisms of Obesity Surgery - Physical Activity and Other Predictors of Hospital Stay, Recovery and Complications After Obesity Surgery	Suspended	NCT01998815
30	Metabolic Consequences of Gastrointestinal Surgery	Terminated	NCT02836353	Not Applicable	Somatostatin;Rifaximin
31	Assessment of Gastric Emptying Speed in Patients Who Experience Diarrhea Following a Trigger Meal	Withdrawn	NCT01114113	Not Applicable	pancelipase/placebo
32	Neujia Anastomosis for Treatment of Obesity and Type II Diabetes	Withdrawn	NCT03675074	Not Applicable

Search NIH Clinical Center for Dumping Syndrome

Cochrane evidence based reviews: dumping syndrome

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Genetic Tests for Dumping Syndrome

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Anatomical Context for Dumping Syndrome

MalaCards organs/tissues related to Dumping Syndrome:

⁴²

Small Intestine, Testes, Pituitary, Pancreas, Lung, Breast, Whole Blood

Sources

Publications for Dumping Syndrome

Articles related to Dumping Syndrome:

(show top 50) (show all 918)

#	Title	Authors	Year
1	Prevalence of Dumping Syndrome After Laparoscopic Sleeve Gastrectomy and Comparison with Laparoscopic Roux-en-Y Gastric Bypass. ( 30635813 )	Ahmad A...Broggelwirth B	2019
2	A Real-World, Insurance-Based Algorithm Using the Two-Fold Running Suture Technique for Transoral Outlet Reduction for Weight Regain and Dumping Syndrome After Roux-En-Y Gastric Bypass. ( 30937874 )	Fayad L...Kumbhari V	2019
3	Heterogeneity in the Definition and Clinical Characteristics of Dumping Syndrome: a Review of the Literature. ( 30941693 )	Gys B...Hubens G	2019
4	Prevalence and pathophysiology of early dumping in patients after primary Roux-en-Y gastric bypass during a mixed-meal tolerance test. ( 30446401 )	Wijma RB...van Beek AP	2019
5	Prevalence and pathophysiology of early dumping in patients after primary Roux-en-Y gastric bypass during a mixed-meal tolerance test. ( 30503167 )	Rogers AM	2019
6	Detection of waste dumping locations in landfill using multi-temporal Landsat thermal images. ( 30632930 )	Gill J...Yan WY	2019
7	Distribution of butyltins at dredged material dumping sites around the coast of China and the potential ecological risk. ( 30660299 )	Wang X...Han J	2019
8	Age of both parents influences reproduction and egg dumping behavior in Drosophila melanogaster. ( 30753690 )	Mossman JA...Rand DM	2019
9	Patient Dumping. ( 30801292 )	Contrado T	2019
10	Ocean Dumping of Containerized DDT Waste Was a Sloppy Process. ( 30829032 )	Kivenson V...Valentine DL	2019
11	A novel initiative to counteract illegal dumping in rural areas of Valladolid Province (Spain). ( 30854620 )	Hidalgo D...Mart?n-Marroqu?n JM	2019
12	Pulsed output generation in a diode-pumped cesium vapor laser using the cavity dumping technique. ( 30874638 )	Endo M	2019
13	Fractionation and risk assessment of metals in sediments of an ocean dumping site. ( 30955729 )	Jung JM...Kim SH	2019
14	Potential of fungi isolated from the dumping sites mangrove rhizosphere soil to degrade polythene. ( 30926843 )	Sangale MK...Ade AB	2019
15	Effectiveness of sitagliptin in a patient with late dumping syndrome after total gastrectomy. ( 29208515 )	Kurihara K...Hosoi M	2018
16	Post-Fundoplication Dumping Syndrome: A Frequent "Rare" Complication. ( 29379815 )	Kataria R...Schey R	2018
17	Safety and efficacy of pasireotide in dumping syndrome-results from a phase 2, multicentre study. ( 29696671 )	Tack J...Van Beek AP	2018
18	Transient severe distributive shock due to early dumping syndrome: a case report. ( 30208930 )	Takeshita J...Shime N	2018
19	Applications of peptide hormone ligands for the treatment of dumping and short bowel syndrome. ( 30273889 )	Wauters L...Vanuytsel T	2018
20	946 nm Nd:YAG laser with cavity dumping. ( 30004529 )	Kornev AF...Kovyarov AS	2018
21	Long-term self-reported symptom prevalence of early and late dumping in a patient population after sleeve gastrectomy, primary, and revisional gastric bypass surgery. ( 29858129 )	Emous M...van Beek AP	2018
22	Europe's biggest research fund cracks down on 'ethics dumping'. ( 29970912 )	Nordling L	2018
23	Mercury contamination in the sludge of drinking water treatment plants dumping into a reservoir in Rio de Janeiro, Brazil. ( 30099710 )	Wasserman JC...de Paiva Lima E	2018
24	Phytoremediation of waste dumping site soil and landfill leachate by using cattail (Typha latifolia). ( 30198835 )	Xu Q...Yuan Q	2018
25	Dumping to the abyss: single-use marine litter invading bathyal plains of the Sardinian margin (Tyrrhenian Sea). ( 30301106 )	Cau A...Follesa MC	2018
26	Patient Dumping Is Still a Problem. ( 30358587 )	Kritz F	2018
27	Insight into occurrence, profile and spatial distribution of organochlorine pesticides in soils of solid waste dumping sites of Pakistan: Influence of soil properties and implications for environmental fate. ( 30529619 )	Sultan M...Malik RN	2018
28	Nonmotile Single-Cell Migration as a Random Walk in Nonuniformity: The "Extreme Dumping Limit" for Cell-to-Cell Communications. ( 30595832 )	Panotopoulos GP...Haidar ZS	2018
29	Impact of dredged-material disposal on soft-bottom communities in a recurrent marine dumping area near to Guadalquivir estuary, Spain. ( 29773315 )	Don?zar-Aramend?a I...Garc?a-G?mez JC	2018
30	On the dumping ground genus Scotaena Klug, 1810 (Hymenoptera: Tiphiidae: Thynninae): Phylogeny, taxonomy and geographic distribution. ( 29690290 )	Carnimeo FH...Noll FB	2018
31	Predictors of illegal dumping at charitable collection points. ( 29453014 )	Wright B...Tull F	2018
32	Effects of open dumping of MSW on metal contamination of soil, plants, and earthworms in Ranchi, Jharkhand, India. ( 29442190 )	Singh M...Kumar RN	2018
33	Identifying areas under potential risk of illegal construction and demolition waste dumping using GIS tools. ( 29402616 )	Seror N...Portnov BA	2018
34	Deep sea habitats in the chemical warfare dumping areas of the Baltic Sea. ( 29111251 )	Czub M...Be?dowski J	2018
35	Improving the monitoring of a dumping site in a dynamic environment. Example of the Octeville site (Bay of Seine, English Channel). ( 29055561 )	M?ar Y...Dauvin JC	2018
36	Assessing the risk of alcohol-induced dose dumping from sustained-release oral dosage forms: in vitro-in silico approach. ( 29043886 )	Cviji? S...Paroj?i? J	2018
37	The Effect of Dumping on Weight Loss in Conversion of Failed Restrictive Surgery: a Cross-Sectional Pilot Study. ( 28933032 )	Van Looveren R...Smet B	2018
38	Late Dumping Syndrome in a 17-Year-Old Female With Charge Syndrome. ( 29205658 )	Morgan A...Blake K	2017
39	Severe Dumping Syndrome in a 6-year-old Girl with Congenital Microgastria Treated by Hunt-Lawrence Pouch. ( 28361011 )	Filisetti C...Riccipetitoni G	2017
40	Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management. ( 27749997 )	van Beek AP...Tack J	2017
41	Dumping syndrome after esophagectomy: a systematic review of the literature. ( 27859950 )	Boshier PR...Hanna GB	2017
42	A case report: Liraglutide as a novel treatment option in late dumping syndrome. ( 28328816 )	Chiappetta S...Stier C	2017
43	Pregnancy and Dumping Syndrome post-bariatric surgery: a case report. ( 28473681 )	Edawati DE...Harris NS	2017
44	The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life. ( 28624531 )	Emous M...van Beek AP	2017
45	Incretin Kinetics Before and After Miglitol in Japanese Patients With Late Dumping Syndrome. ( 28912925 )	Amagai M...Terauchi Y	2017
46	Pasireotide and octreotide in the treatment of severe late dumping syndrome. ( 29026555 )	Mohammadi A...Grossman AB	2017
47	Experience with FreeStyle Libre Flash glucose monitoring system in management of refractory dumping syndrome in pregnancy shortly after bariatric surgery. ( 29302329 )	Novodvorsky P...Munir A	2017
48	Dumping the information bucket: A qualitative study of clinicians caring for patients with early stage non-small cell lung cancer. ( 28034611 )	Golden SE...Early Stage Lung Cancer Comparative Effectiveness Research Consortium	2017
49	High peak power cavity dumping semiconductor lasers. ( 28059191 )	Myers J...Bedford R	2017
50	Traffic accident or dumping? - Striking results of a traffic accident reconstruction. ( 28081791 )	Nerger E...Ondruschka B	2017

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Genes for Dumping Syndrome

Genes related to Dumping Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SST	Somatostatin	Protein Coding	31.64	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8103615 1978748 19724252 (more) 8359570 8317033 19264574 7933883
2	NTS	Neurotensin	Protein Coding	29.74	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	9403815
3	PYY	Peptide YY	Protein Coding	26.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	1415124
4	GCG	Glucagon	Protein Coding	25.16	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	16416173 9200302 11575444
5	INS	Insulin	Protein Coding	23.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	GIP	Gastric Inhibitory Polypeptide	Protein Coding	22.63	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	SCT	Secretin	Protein Coding	20.67	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Dumping Syndrome

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Expression for Dumping Syndrome

Search GEO for disease gene expression data for Dumping Syndrome.

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Pathways for Dumping Syndrome

Pathways related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁷ Show member pathways GPCR downstream signaling ⁶⁷ Signal Transduction ⁶⁷	13.4	GCG GIP INS NTS PYY SCT
2	Aldosterone synthesis and secretion ³⁸ Show member pathways Adrenergic signaling in cardiomyocytes ³⁸ Ca2+ activated K+ channels ⁶⁷ Cortisol synthesis and secretion ³⁸ Cushing syndrome ³⁸ Insulin secretion ³⁸ Melanogenesis ³⁸ Thyroid hormone synthesis ³⁸	12.47	GCG GIP INS
3	Peptide ligand-binding receptors ⁶⁷ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁷ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁷ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁷ G alpha (i) signalling events ⁶⁷ GPCR ligand binding ⁶⁷ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁸ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁷ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁷ Vasopressin-like receptors ⁶⁷	12.38	GCG GIP NTS PYY SCT SST
4	Presynaptic function of Kainate receptors ⁶⁷ Show member pathways Activation of Ca-permeable Kainate Receptor ⁶⁷ Activation of Kainate Receptors upon glutamate binding ⁶⁷ Activation of Na-permeable Kainate Receptors ⁶⁷ Calcitonin-like ligand receptors ⁶⁷ Class B/2 (Secretin family receptors) ⁶⁷ G beta-gamma signalling through PLC beta ⁶⁷ Glucagon-type ligand receptors ⁶⁷ G-Protein Signaling through Tubby Protein ⁶⁵ Ionotropic activity of Kainate Receptors ⁶⁷	11.9	GCG GIP SCT
5	Peptide hormone metabolism ⁶⁷ Show member pathways Glycoprotein hormones ⁶⁷ Insulin processing ⁶⁷ Metabolism of Angiotensinogen to Angiotensins ⁶⁷ Peptide hormone biosynthesis ⁶⁷ Synthesis, secretion, and deacylation of Ghrelin ⁶⁷	11.69	GCG GIP INS
6	G alpha (s) signalling events ⁶⁷	11.3	GCG GIP SCT
7	Incretin synthesis, secretion, and inactivation ⁶⁷ Show member pathways Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ⁶⁷ Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) ⁶⁷	11.15	GCG GIP
8	FOXA1 transcription factor network ¹ Show member pathways FOXA transcription factor networks ¹	11.03	GCG INS

Sources

GO Terms for Dumping Syndrome

Cellular components related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.43	GCG GIP INS
2	extracellular space	GO:0005615	9.43	GCG GIP INS PYY SCT SST
3	secretory granule lumen	GO:0034774	9.33	GCG GIP INS
4	transport vesicle	GO:0030133	9.32	INS NTS
5	extracellular region	GO:0005576	9.17	GCG GIP INS NTS PYY SCT

Biological processes related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor signaling pathway	GO:0007186	9.5	GCG GIP INS NTS PYY SCT
2	regulation of insulin secretion	GO:0050796	9.4	GCG GIP
3	response to amino acid	GO:0043200	9.37	GIP SST
4	feeding behavior	GO:0007631	9.32	GCG PYY
5	positive regulation of cAMP-mediated signaling	GO:0043950	9.26	GIP SCT
6	regulation of signaling receptor activity	GO:0010469	9.17	GCG GIP INS NTS PYY SCT
7	response to acidic pH	GO:0010447	9.16	GIP SST

Molecular functions related to Dumping Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor binding	GO:0001664	9.16	PYY SCT
2	hormone activity	GO:0005179	9.1	GCG GIP INS PYY SCT SST
3	neuropeptide hormone activity	GO:0005184	8.96	NTS PYY

Sources

Sources for Dumping Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia