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MCID: DMP001
MIFTS: 43

Dumping Syndrome

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Dumping Syndrome

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MalaCards integrated aliases for Dumping Syndrome:

Name: Dumping Syndrome 12 54 44 15 17 71
Dumping 54 71
Postgastrectomy Syndromes 71
Dumping Syndrome 12
Jejunal Syndrome 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:14495
MeSH 44 D004377
NCIt 50 C2994
SNOMED-CT 67 155785007
ICD10 32 K91.1
UMLS 71 C0013288 C0032763 C0221542
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Summaries for Dumping Syndrome

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MalaCards based summary : Dumping Syndrome, also known as dumping, is related to hypoglycemia and hyperinsulinemic hypoglycemia, and has symptoms including constipation, pain, postoperative and postoperative nausea and vomiting. An important gene associated with Dumping Syndrome is GCG (Glucagon), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs lanreotide and Pasireotide have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and breast.

Wikipedia : 74 Dumping syndrome occurs when food, especially sugar, moves too quickly from the stomach to the... more...

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Related Diseases for Dumping Syndrome

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Diseases related to Dumping Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 hypoglycemia 31.3 SST INS GCG
2 hyperinsulinemic hypoglycemia 30.3 SST INS GCG
3 peptic esophagitis 30.2 MLN GAST
4 hyperinsulinism 30.2 SST INS GHRL GCG
5 peptic ulcer disease 30.1 SST SCT GHRL GAST
6 glucose intolerance 29.8 SST INS GHRL GCG
7 pyloric stenosis 29.7 SST MLN GAST
8 leptin deficiency or dysfunction 29.7 PYY INS GHRL GCG CCK
9 biliary dyskinesia 29.3 SST SCT CCK
10 insulinoma 29.2 SST SCT INS GCG GAST
11 liver cirrhosis 29.2 SST SCT INS GCG
12 duodenal ulcer 29.2 SST SCT MLN INS GAST CCK
13 gastritis 29.2 SST SCT GHRL GAST
14 gastroesophageal reflux 29.2 PYY NTS MLN GHRL GCG GAST
15 hyperglycemia 29.0 SST PYY INS GIP GHRL GCG
16 irritable bowel syndrome 28.9 SST PYY MLN GHRL CCK
17 bile reflux 28.9 SCT MLN GAST CCK
18 gastrointestinal system disease 28.9 MLN GHRL GCG GAST CCK
19 diarrhea 28.7 SST SCT PYY NTS MLN GAST
20 short bowel syndrome 28.3 SST PYY NTS GHRL GCG GAST
21 duodenogastric reflux 28.3 SST SCT PYY NTS MLN GAST
22 body mass index quantitative trait locus 11 28.1 PYY NTS MLN INS GIP GHRL
23 gastroparesis 28.0 SST SCT MLN GIP GHRL GAST
24 constipation 27.8 SST PYY NTS MLN INS GHRL
25 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.4
26 splenic flexure cancer 10.3 INS GCG
27 hypoglycemic coma 10.3 INS GCG
28 acute insulin response 10.3 INS GCG
29 acidophil adenoma 10.2 SST INS
30 angular cheilitis 10.2 SST GCG
31 adenosquamous bile duct carcinoma 10.2 GIP GCG
32 pituitary infarct 10.2 SST INS
33 paralytic ileus 10.2 MLN INS
34 functional colonic disease 10.2 SST MLN
35 meckel diverticulum 10.2 SST GCG
36 colonic pseudo-obstruction 10.2 SST MLN
37 barre-lieou syndrome 10.2 GIP GCG
38 transient refractive change 10.2 SST INS
39 diabetes mellitus, ketosis-prone 10.2 INS GCG
40 autonomic nervous system disease 10.2 INS GCG
41 pituitary apoplexy 10.2 SST INS
42 gastrojejunal ulcer 10.2 PYY NTS
43 pancreatoblastoma 10.2 SST NTS
44 hyperpituitarism 10.2 SST INS
45 maturity-onset diabetes of the young, type 1 10.2 INS GCG
46 esophageal varix 10.2 SST INS
47 afferent loop syndrome 10.2
48 glycogen storage disease ia 10.2 INS GCG
49 neurogenic bowel 10.2 MLN GAST
50 diencephalic astrocytoma 10.1 INS GHRL

Graphical network of the top 20 diseases related to Dumping Syndrome:



Diseases related to Dumping Syndrome
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Symptoms & Phenotypes for Dumping Syndrome

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UMLS symptoms related to Dumping Syndrome:


constipation, pain, postoperative, postoperative nausea and vomiting, vomiting following gastrointestinal surgery
Sources

Drugs & Therapeutics for Dumping Syndrome

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Drugs for Dumping Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
lanreotide Approved Phase 4 108736-35-2
2
Pasireotide Approved Phase 4 396091-73-9 9941444
3
Lactitol Approved, Investigational Phase 4 585-86-4 157355
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Cabergoline Approved Phase 4 81409-90-7 54746
6 Angiopeptin Phase 4
7 Dopamine Agents Phase 4
8 Dopamine agonists Phase 4
9 Neurotransmitter Agents Phase 4
10 Antiparkinson Agents Phase 4
11
Domperidone Approved, Investigational, Vet_approved 57808-66-9 3151
12
Glucagon Approved 16941-32-5
13
Empagliflozin Approved 864070-44-0
14
Acetaminophen Approved 103-90-2 1983
15
Octreotide Approved, Investigational 83150-76-9 383414 6400441
16
Sulfasalazine Approved 599-79-1 5353980 5359476
17
Somatostatin Approved, Investigational 51110-01-1, 38916-34-6 53481605
18
Rifaximin Approved, Investigational 80621-81-4 6436173 46783403
19 Sodium-Glucose Transporter 2 Inhibitors
20 Hypoglycemic Agents
21 Interleukin 1 Receptor Antagonist Protein
22 Pharmaceutical Solutions
23 Insulin, Globin Zinc
24 Glucagon-Like Peptide 1
25 insulin
26 Analgesics, Non-Narcotic
27 Anti-Inflammatory Agents
28 Anti-Inflammatory Agents, Non-Steroidal
29 Analgesics
30 Antirheumatic Agents
31 Antineoplastic Agents, Hormonal
32 Nutrients
33 Antipyretics
34 Hormones
35 Hormone Antagonists
36 Gastrointestinal Agents
37 Anti-Infective Agents
38 Antibiotics, Antitubercular
39 Anti-Bacterial Agents

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
2 An Open Label, Multi-center Pasireotide Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Pasireotide Study and Are Judged by the Investigator to Benefit From Continued Pasireotide Treatment Active, not recruiting NCT01794793 Phase 4 Pasireotide;Cabergoline;Pasireotide
3 Hyperbaric Oxygenation (HBO) in Chronic Diabetic Leg Ulcer. Not yet recruiting NCT02042339 Phase 3 Hyperbaric oxygen
4 SOMATULINE Autogel 90 mg IN DUMPING SYNDROME Unknown status NCT01923649 Phase 2 Lanreotide 90 mg slow release formulation;Placebo
5 Exploratory Randomized, Placebo-controlled Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome Completed NCT01895296 Phase 2 Pasireotide;Placebo
6 A Multi-center, Intra-patient Dose Escalation Phase II Study to Evaluate the Preliminary Efficacy, Safety and Pharmacokinetics of Pasireotide (SOM230) Subcutaneous (s.c.) Followed by Pasireotide LAR in Patients With Dumping Syndrome Completed NCT01637272 Phase 2 SOM230
7 A Pilot Phase II Study of Hyperbaric Oxygen for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (HOPPS) Completed NCT01306968 Phase 2 hyperbaric oxygen
8 A Phase II, Community-based, Single-blinded, Randomized Controlled, Parallel-group Trial to Assess the Effects of a Tailored Positive Psychology Intervention on Chronic Pain and Well-being in Individuals With Spinal Cord Injury Completed NCT02459028 Phase 2
9 A Prospective Randomised Study Comparing Billroth II With Roux-en-Y Reconstruction After Radical Distal Subtotal Gastrectomy for Gastric Cancer Unknown status NCT01257711
10 European Dumping Study: Validation of a Diagnostic Tool for Postprandial Hypoglycaemia in Patients After Roux en Y Gastric Bypass Surgery Unknown status NCT03406312
11 Use and Misuse of Domperidone in Parkinson's Disease in France - Dump Investigation Unknown status NCT03837067
12 Frequency of Occurrence of Dumping Syndrome After Operation of Esophageal Atresia Type III Completed NCT02525705
13 The Effect of Glucagon Like Peptide-1 (GLP-1) on Glycaemic Profile and Eating Behaviour Following Gastrectomy Completed NCT02971631
14 Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study Completed NCT03200782 Empagliflozin;Anakinra
15 The Effect of Fat Supplementation on the Appearance of Symptoms Associated With Dumping Syndrome in Patients Undergone Bariatric Surgery Recruiting NCT04028193
16 Assessing the Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity With the Risk of Occurrence of Dumping Syndrome After Gastric Bypass. Recruiting NCT02891330
17 Incidence of Dumping Syndrome After Laparoscopic Vagus Nerve-preserving Distal Gastrectomy for Early Gastric Cancer Recruiting NCT03880747
18 MAgnetic Gastrointestinal Universal Septotome: a Safety and Feasibility Study Recruiting NCT04480216
19 Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery Enrolling by invitation NCT03734627 Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine
20 Physiopathology of Dumping Syndrome in Esophageal Atresia Not yet recruiting NCT04522193
21 The Metabolic Consequences of Gastrointestinal Surgery Terminated NCT02836353 Somatostatin;Rifaximin

Search NIH Clinical Center for Dumping Syndrome

Cochrane evidence based reviews: dumping syndrome

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Genetic Tests for Dumping Syndrome

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Anatomical Context for Dumping Syndrome

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MalaCards organs/tissues related to Dumping Syndrome:

40
Small Intestine, Colon, Breast, Skin, Eye, Spinal Cord, Pancreas
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Publications for Dumping Syndrome

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Articles related to Dumping Syndrome:

(show top 50) (show all 3764)
# Title Authors PMID Year
1
Pathophysiology, diagnosis and management of postoperative dumping syndrome. 61 54
19724252 2009
2
Efficacy of the long-acting repeatable formulation of the somatostatin analogue octreotide in postoperative dumping. 54 61
19264574 2009
3
A possible role of GLP-1 in the pathophysiology of early dumping syndrome. 54 61
16416173 2005
4
Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome. 61 54
11575444 2001
5
Gastrointestinal hormone in dumping syndrome and reflux esophagitis after gastric surgery. 61 54
9403815 1997
6
The dumping syndrome. Current insights into pathophysiology, diagnosis and treatment. 54 61
9200302 1997
7
[Neurohumoral regulation of gastric secretion in postvagotomy syndromes]. 54 61
7933883 1994
8
[Postgastrectomy dumping treated with octreotide (Sandostatin)]. 61 54
8317033 1993
9
The effect of somatostatin in dumping syndrome after gastric surgery. 61 54
8103615 1993
10
Potential indications for octreotide in gastroenterology: summary of workshop. 61 54
8359570 1993
11
Atrial natriuretic peptide in dumping syndrome. 54 61
8513987 1993
12
Dumping syndrome and the regulation of peptide YY with verapamil. 61 54
1415124 1992
13
Decreased activity of atrial natriuretic peptide in dumping syndrome after gastric surgery. 54 61
1830840 1991
14
[The effect of somatostatin in dumping syndrome]. 61 54
1978748 1990
15
[Atrial natriuretic peptide in dumping syndrome]. 54 61
2146582 1990
16
A preliminary study on the ecotoxic potency of wastewater treatment plant sludge combining passive sampling and bioassays. 61
33257078 2021
17
Bioaccumulation of legacy and emerging organophosphorus flame retardants and plasticizers in insects during metamorphosis. 61
33316674 2021
18
Continuous Glucose Monitoring to Diagnose Hypoglycemia Due to Late Dumping Syndrome in Children After Gastric Surgeries. 61
33506160 2021
19
Environmental status of an Italian site highly polluted by illegal dumping of industrial wastes: The situation 15 years after the judicial intervention. 61
33360460 2021
20
Environmental performance and functional analysis of chip seals with recycled basic oxygen furnace slag as aggregate. 61
33162241 2021
21
Shift of nitrate sources in groundwater due to intensive livestock farming on Jeju Island, South Korea: With emphasis on legacy effects on water management. 61
33461081 2021
22
Acetobacter orientalis XJC-C with a high lignocellulosic biomass-degrading ability improves significantly composting efficiency of banana residues by increasing metabolic activity and functional diversity of bacterial community. 61
33440312 2021
23
Microbial degradation of Procion Red by Pseudomonas stutzeri. 61
33542307 2021
24
Solid waste management and health hazards associated with residence around open dumpsites in heterogeneous urban settlements in Southwest Nigeria. 61
33586533 2021
25
Temporal variation of leachate pollution index of Indian landfill sites and associated human health risk. 61
33543433 2021
26
Understanding metal dissolution from solar photovoltaics in MSW leachate under standard waste characterization conditions for informing end-of-life photovoltaic waste management. 61
33581641 2021
27
Metal pollution as a potential threat to shell strength and survival in marine bivalves. 61
33160677 2021
28
Risk factors of dumping syndrome after fundoplication for gastroesophageal reflux in children. 61
33388966 2021
29
Early experience with a nutrition and survivorship clinic in esophageal cancer. 61
32566939 2021
30
SGLT2 inhibition alleviated hyperglycemia, glucose intolerance, and dumping syndrome-like symptoms in a patient with glycogen storage disease type Ia: a case report. 61
33588940 2021
31
Gastric pull-up by the retrosternal route for esophageal replacement: Feasibility in a limited-resource scenario. 61
32439181 2021
32
Reply to: Late dumping syndrome or postprandial reactive hypoglycaemic syndrome after bariatric surgery. 61
33536608 2021
33
Late dumping syndrome or postprandial reactive hypoglycaemic syndrome after bariatric surgery. 61
33536609 2021
34
Atmospheric Occurrence of Organochlorine Pesticides and Inhalation Cancer Risk in Urban Areas at Southeast Brazil. 61
33535363 2021
35
Cleaner agricultural production in drinking-water source areas for the control of non-point source pollution in China. 61
33582473 2021
36
Impact of serpentinized peridotite mine waste on the composition and quality of sediments in the Ría de Ortigueira (Galicia, NW Spain). 61
33486404 2021
37
Mysterious oil spill on Brazilian coast: Analysis and estimates. 61
33582423 2021
38
Hydrodynamic modeling and radiotracer investigations in Kolkata Port Trust, Kolkata, West Bengal, India. 61
33310506 2021
39
Recommendations for nutritional care after bariatric surgery: Recommendations for best practice and SOFFCO-MM/AFERO/SFNCM/expert consensus. 61
33436155 2021
40
Antimicrobial sensitivity profiling of bacterial communities recovered from effluents of municipal solid waste dumping site. 61
33479592 2021
41
Complications in patients with neurological impairment after gastrostomy. 61
33560541 2021
42
Identification of (anti-)androgenic activities and risks of sludges from industrial and domestic wastewater treatment plants. 61
33011575 2021
43
Plastic pollution on the Colombian central Caribbean beaches. 61
33203601 2021
44
Policy responses to reduce single-use plastic marine pollution in the Caribbean. 61
33213855 2021
45
Speciation, contamination, ecological and human health risks assessment of heavy metals in soils dumped with municipal solid wastes. 61
33182094 2021
46
Trace volatile compounds in the air of domestic waste landfill site: Identification, olfactory effect and cancer risk. 61
33476794 2021
47
Mapping the Illegal International Ivory Trading Network to Identify Key Hubs and Smuggling Routes : Illegal International Ivory Trading Network from 1975 to 2017. 61
33389327 2021
48
Endoscopic trans-oral outlet reduction after bariatric surgery is safe and effective for dumping syndrome. 61
33398583 2021
49
Gastric pouch sero-myotomy for persistent dysphagia after roux-en-Y gastric bypass: Video report. 61
33321407 2021
50
Laparoscopic Gastric Bypass Reversal with Concomitant Sleeve Gastrectomy (SG) for Refractory Hypoglycemia: an Unusual Procedure. 61
33165754 2021
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Variations for Dumping Syndrome

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Expression for Dumping Syndrome

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Search GEO for disease gene expression data for Dumping Syndrome.
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Pathways for Dumping Syndrome

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Pathways related to Dumping Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 13.59 SST SCT PYY NTS MLN INS
2
Peptide ligand-binding receptors 65
Show member pathways
 12.56 SST SCT PYY NTS MLN GIP
3
Aldosterone synthesis and secretion 36
Show member pathways
 12.53 INS GIP GCG CCK
4
Salivary secretion 36
Show member pathways
 12.14 SST SCT GAST CCK
5
Presynaptic function of Kainate receptors 65
Show member pathways
 12.05 SCT GIP GCG
6
cAMP signaling pathway 36
12 SST GIP GHRL GCG
7
Peptide hormone metabolism 65
Show member pathways
 11.88 INS GIP GHRL GCG
8
G alpha (s) signalling events 65
11.77 SCT GIP GCG
9
FOXA1 transcription factor network 1
Show member pathways
 11.16 INS GCG
10
Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics 60
10.73 PYY INS GHRL
11
Gastric acid production 1
9.98 SCT GAST CCK
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GO Terms for Dumping Syndrome

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Cellular components related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 SST SCT PYY INS GIP GHRL
2 endoplasmic reticulum lumen GO:0005788 9.56 INS GIP GHRL GCG
3 secretory granule lumen GO:0034774 9.46 INS GIP GHRL GCG
4 extracellular region GO:0005576 9.36 SST SCT PYY NTS MLN INS

Biological processes related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of insulin secretion GO:0032024 9.46 GIP GHRL
2 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.43 GHRL GCG
3 response to amino acid GO:0043200 9.4 SST GIP
4 feeding behavior GO:0007631 9.37 PYY GCG
5 G protein-coupled receptor signaling pathway GO:0007186 9.36 SST SCT PYY NTS MLN INS
6 digestion GO:0007586 9.32 SST CCK
7 positive regulation of cAMP-mediated signaling GO:0043950 9.26 SCT GIP
8 response to acidic pH GO:0010447 9.16 SST GIP
9 response to nutrient levels GO:0031667 9.13 SCT GIP GHRL

Molecular functions related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.43 SCT PYY GHRL
2 hormone activity GO:0005179 9.32 SST SCT PYY MLN INS GIP
3 glucagon receptor binding GO:0031769 9.16 GIP GCG
4 neuropeptide hormone activity GO:0005184 9.13 PYY NTS CCK
Sources

Sources for Dumping Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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