Aliases & Classifications for Dumping Syndrome

MalaCards integrated aliases for Dumping Syndrome:

Name: Dumping Syndrome 12 55 44 15 73
Dumping 55 73
Postgastrectomy Syndromes 73
Dumping Syndrome 12
Jejunal Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14495
ICD10 33 K91.1
MeSH 44 D004377
NCIt 50 C2994

Summaries for Dumping Syndrome

MalaCards based summary : Dumping Syndrome, also known as dumping, is related to hyperinsulinemic hypoglycemia and gastroesophageal reflux, and has symptoms including constipation, pain, postoperative and vomiting following gastrointestinal surgery. An important gene associated with Dumping Syndrome is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs lanreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver.

Wikipedia : 76 Dumping syndrome occurs when food, especially sugar, moves too fast from the stomach to the duodenum—the... more...

Related Diseases for Dumping Syndrome

Diseases related to Dumping Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 hyperinsulinemic hypoglycemia 29.7 INS SST
2 gastroesophageal reflux 29.2 GCG NTS PYY
3 duodenal ulcer 29.1 INS SCT SST
4 constipation 29.0 NTS PYY SST
5 insulinoma 28.4 GCG INS SCT SST
6 duodenogastric reflux 28.2 NTS PYY SCT SST
7 type 1 diabetes mellitus 15 10.4 GCG INS
8 acute insulin response 10.3 GCG INS
9 pancreatoblastoma 10.3 NTS SST
10 prediabetes syndrome 10.2 GCG INS
11 duodenal somatostatinoma 10.2 INS SST
12 postural hypotension 10.2 INS SST
13 hyperproinsulinemia 10.2 INS SCT
14 hypoglycemia 10.2
15 hyperpituitarism 10.2 INS SST
16 somatostatinoma 10.2 INS SST
17 pancreatic gastrinoma 10.2 SCT SST
18 glucagonoma 10.1 SCT SST
19 islet cell tumor 10.1 INS SST
20 angiodysplasia 10.1 SCT SST
21 pituitary-dependent cushing's disease 10.1 INS SST
22 glucose intolerance 10.1 GCG INS
23 duodenal gastrinoma 10.1 SCT SST
24 pituitary gland disease 10.1 INS SST
25 steatorrhea 10.0 SCT SST
26 esophagitis 10.0
27 diarrhea 10.0
28 cell type benign neoplasm 10.0 INS SST
29 gallbladder disease 10.0 INS SST
30 gastric cancer 10.0
31 peptic ulcer disease 10.0
32 acromegaly 9.9 INS SST
33 serotonin syndrome 9.9 PYY SST
34 duodenitis 9.9
35 congenital microgastria 9.9
36 hyperthyroidism 9.9 INS SST
37 vipoma 9.8 NTS SCT SST
38 zollinger-ellison syndrome 9.8 NTS SCT SST
39 schizophrenia 9.7
40 tracheoesophageal fistula with or without esophageal atresia 9.7
41 charge syndrome 9.7
42 angina pectoris 9.7
43 liver cirrhosis 9.7
44 esophageal atresia 9.7
45 microinvasive gastric cancer 9.7
46 gastroenteritis 9.7
47 pancreatitis 9.7
48 gastroduodenitis 9.7
49 acute pancreatitis 9.7 SCT SST
50 endocrine gland cancer 9.7 GCG SCT SST

Graphical network of the top 20 diseases related to Dumping Syndrome:



Diseases related to Dumping Syndrome

Symptoms & Phenotypes for Dumping Syndrome

UMLS symptoms related to Dumping Syndrome:


constipation, pain, postoperative, vomiting following gastrointestinal surgery, postoperative nausea and vomiting

Drugs & Therapeutics for Dumping Syndrome

Drugs for Dumping Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 lanreotide Approved Phase 4,Phase 2 108736-35-2
2
Somatostatin Approved, Investigational Phase 4,Phase 2,Not Applicable 38916-34-6, 51110-01-1 53481605
3
Lactitol Investigational Phase 4 585-86-4 3871
4 Angiopeptin Phase 4,Phase 2
5 Hormone Antagonists Phase 4,Phase 2,Not Applicable
6 Hormones Phase 4,Phase 2,Not Applicable
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
8 Pharmaceutical Solutions Phase 2
9
Loperamide Approved Not Applicable 53179-11-6 3955
10
Empagliflozin Approved Not Applicable 864070-44-0
11
Rifaximin Approved, Investigational Not Applicable 80621-81-4 6436173
12 Narcotics
13 Dipeptidyl-Peptidase IV Inhibitors Not Applicable
14 HIV Protease Inhibitors Not Applicable
15 Hypoglycemic Agents Not Applicable
16 Incretins Not Applicable
17
protease inhibitors Not Applicable
18 Sitagliptin Phosphate Not Applicable
19 Antidiarrheals Not Applicable
20 Gastrointestinal Agents Not Applicable
21 Antirheumatic Agents Not Applicable
22 insulin Not Applicable
23 Insulin, Globin Zinc Not Applicable
24 Interleukin 1 Receptor Antagonist Protein Not Applicable
25 Anti-Bacterial Agents Not Applicable
26 Antibiotics, Antitubercular Not Applicable
27 Anti-Infective Agents Not Applicable
28 Nucleic Acid Synthesis Inhibitors Not Applicable
29 glucagon Not Applicable
30 Glucagon-Like Peptide 1 Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Treatment of the Dumping Syndrome With Lanreotide Autogel® Unknown status NCT00543179 Phase 4 Somatuline (Lanreotide Autogel®)
2 Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study. Recruiting NCT01794793 Phase 4 Pasireotide
3 Impact of the Techniques for Intrathoracic Esophagogastric Anastomosis on Outcome in Ivor-Lewis Oesophagectomy Unknown status NCT01242124 Phase 2, Phase 3
4 Comparison of Laparoscopic Pylorus Preserving Gastrectomy Versus Laparoscopic Distal Gastrectomy Recruiting NCT02595086 Phase 3
5 Randomized Controlled Trials Comparing Clinical Outcomes of 3D Versus 2D Laparoscopic Surgery for Gastric Cancer Active, not recruiting NCT02327481 Phase 3
6 SOMATULINE Autogel 90 mg IN DUMPING SYNDROME Unknown status NCT01923649 Phase 2 Lanreotide 90 mg slow release formulation;Placebo
7 Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome Completed NCT01895296 Phase 2 Pasireotide;Placebo
8 Phase II Study Evaluating Efficacy, Safety and Pharmacokinetics of Pasireotide in Patients With Dumping Syndrome Completed NCT01637272 Phase 2 SOM230
9 Evaluation of Single Ascending Doses of Subcutaneous Exendin 9-39 in Patients With Post-Bariatric Hypoglycemia Active, not recruiting NCT02996812 Phase 1 Exendin (9-39)
10 Banded Sleeve Gastrectomy Versus Banded Ring Gastric Bypass in Morbidly Obese Patients Unknown status NCT00873405 Not Applicable
11 A Study Comparing Billroth II With Roux-en-Y Reconstruction for Gastric Cancer Unknown status NCT01257711 Not Applicable
12 Idiopathic Reactive Hypoglycaemia and Treatment With Fructo-Oligosaccharide Completed NCT00802971 Not Applicable
13 Chronic Marginal Ulcers After Gastric Bypass Completed NCT01041079
14 Treatment of Diabetes After Gastric Bypass With Sitagliptin Completed NCT01512797 Not Applicable Sitagliptin phosphate
15 Omega Loop Versus Roux-en-Y Gastric Bypass Completed NCT02139813 Not Applicable
16 Impact of an Educational Personalized Clinical Support Device Preventive and a Referent Nurse in Surgery for Obesity Recruiting NCT02891330 Not Applicable
17 Dumping Syndrome After Operation of Esophageal Atresia Type III Recruiting NCT02525705 Not Applicable
18 Comparisons Between Isoperistaltic and Antiperistaltic Gastrojejunostomy in Laparoscopic Distal Gastrectomy Recruiting NCT02837874 Not Applicable
19 Postprandial Hypoglycemia in Patients After Bariatric Surgery With Empagliflozin and Anakinra - The Hypo-BEAR-Study Recruiting NCT03200782 Not Applicable Empagliflozin;Anakinra
20 Metabolic Consequences of Gastrointestinal Surgery Recruiting NCT02836353 Not Applicable Somatostatin;Rifaximin
21 Laparoscopic Versus Open Gastrectomy for Gastric Cancer Recruiting NCT02248519 Not Applicable
22 Routine Post-Operative Supplemental Nutrition Active, not recruiting NCT02297607 Not Applicable
23 Role and Mechanisms of Obesity Surgery - Physical Activity and Other Predictors of Hospital Stay, Recovery and Complications After Obesity Surgery Active, not recruiting NCT01998815
24 Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study Active, not recruiting NCT01778738 Not Applicable
25 Gastrectomy, Eating Behaviour and GLP-1 Enrolling by invitation NCT02971631 Not Applicable
26 Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans Enrolling by invitation NCT02710370
27 Assessment of Gastric Emptying Speed in Patients Who Experience Diarrhea Following a Trigger Meal Withdrawn NCT01114113 Not Applicable pancelipase/placebo

Search NIH Clinical Center for Dumping Syndrome

Cochrane evidence based reviews: dumping syndrome

Genetic Tests for Dumping Syndrome

Anatomical Context for Dumping Syndrome

MalaCards organs/tissues related to Dumping Syndrome:

41
Small Intestine, Testes, Liver, Brain

Publications for Dumping Syndrome

Articles related to Dumping Syndrome:

(show top 50) (show all 368)
# Title Authors Year
1
Safety and efficacy of pasireotide in dumping syndrome-results from a phase 2, multicentre study. ( 29696671 )
2018
2
Post-Fundoplication Dumping Syndrome: A Frequent "Rare" Complication. ( 29379815 )
2018
3
Severe Dumping Syndrome in a 6-year-old Girl with Congenital Microgastria Treated by Hunt-Lawrence Pouch. ( 28361011 )
2017
4
Effectiveness of sitagliptin in a patient with late dumping syndrome after total gastrectomy. ( 29208515 )
2017
5
A case report: Liraglutide as a novel treatment option in late dumping syndrome. ( 28328816 )
2017
6
Late Dumping Syndrome in a 17-Year-Old Female With Charge Syndrome. ( 29205658 )
2017
7
Pregnancy and Dumping Syndrome post-bariatric surgery: a case report. ( 28473681 )
2017
8
Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management. ( 27749997 )
2017
9
The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life. ( 28624531 )
2017
10
Incretin Kinetics Before and After Miglitol in Japanese Patients With Late Dumping Syndrome. ( 28912925 )
2017
11
Pasireotide and octreotide in the treatment of severe late dumping syndrome. ( 29026555 )
2017
12
Experience with FreeStyle Libre Flash glucose monitoring system in management of refractory dumping syndrome in pregnancy shortly after bariatric surgery. ( 29302329 )
2017
13
Dumping Syndrome ( 29261889 )
2017
14
Risk of Dumping Syndrome after Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: Early Results of a Multicentre Prospective Study. ( 27242898 )
2016
15
Dumping syndrome after esophagectomy: a systematic review of the literature. ( 27859950 )
2016
16
Specific Features of Dumping Syndrome after Various Types of Gastrectomy as Assessed by a Newly Developed Integrated Questionnaire, the PGSAS-45. ( 26682541 )
2016
17
Durable Flap-Valve Mitigation of Duodenogastric Reflux, A Remnant GastritisA and Dumping Syndrome Following Billroth I Reconstruction. ( 26666548 )
2016
18
PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENTOF DUMPING SYNDROME AND ITS RELATION TO BARIATRIC SURGERY. ( 27683791 )
2016
19
Concurrent Therapy with a Low-carbohydrate Diet and Miglitol Remarkably Improved the Postprandial Blood Glucose and Insulin Levels in a Patient with Reactive Hypoglycemia due to Late Dumping Syndrome. ( 27150868 )
2016
20
Endoluminal Revision (OverStitch (TM) , Apollo Endosurgery) of the Dilated Gastroenterostomy in Patients with Late Dumping Syndrome After Proximal Roux-en-Y Gastric Bypass. ( 27318467 )
2016
21
Early dumping syndrome is not a complication but a desirable feature of Roux-en-Y gastric bypass surgery. ( 27487971 )
2016
22
Temporary dumping syndrome after gastric peroral endoscopic myotomy: should we control the glycemia? ( 26800191 )
2016
23
Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment. ( 26396002 )
2015
24
Dumping Syndrome due to the Misplacement of the Gastrostomy Feeding Tube. ( 26424320 )
2015
25
Improvement of dumping syndrome and oversecretion of glucose-dependent insulinotropic polypeptide following a switch from olanzapine to quetiapine in a patient with schizophrenia. ( 25835510 )
2015
26
A possible difference in the mechanism for postprandial hypoglycemia associated with dumping syndrome between patients with and without type 2 diabetes. ( 26321136 )
2015
27
Conversion to Modified Duodenal Switch for Relieving Intractable Dumping Syndrome and Constipation After Laparoscopic Roux-en-Y Gastric Bypass. ( 25701270 )
2015
28
Verification of glycemic profiles using continuous glucose monitoring: cases with steroid use, liver cirrhosis, enteral nutrition, or late dumping syndrome. ( 25817276 )
2015
29
Erratum: Dumping syndrome following nissen fundoplication in an adult patient diagnosed by continuous online 13C/12C monitoring of (13)C-Octanoic acid breath test "a case report". ( 25956481 )
2015
30
Laparoscopic Conversion to Loop Duodenojejunal Bypass with Sleeve Gastrectomy for Intractable Dumping Syndrome After Roux-en-Y Gastric Bypass-Two Case Reports. ( 25708238 )
2015
31
Dumping syndrome with severe hipoglycemia after Nissen fundoplication in adults. Case report and literature review. ( 25132186 )
2014
32
A pilot study of the effects of the somatostatin analog pasireotide in postoperative dumping syndrome. ( 24750284 )
2014
33
Complications of bariatric surgery: dumping syndrome, reflux and vitamin deficiencies. ( 25194187 )
2014
34
Treatment with acarbose in severe hypoglycaemia due to late dumping syndrome. ( 25117397 )
2013
35
Diazoxide for the treatment of hypoglycaemic dumping syndrome. ( 22147922 )
2013
36
Octreotide improves early dumping syndrome potentially through incretins: a case report. ( 23708181 )
2013
37
The role of dumping syndrome in weight loss after gastric bypass surgery. ( 23233009 )
2013
38
Continuous glucose monitoring for suspected dumping syndrome in infants after Nissen fundoplication. ( 24330287 )
2013
39
Seven-day subcutaneous continuous glucose monitoring demonstrates that treatment with acarbose attenuates late dumping syndrome in a woman with gastrectomy for gastric cancer. ( 23146372 )
2013
40
Dumping syndrome following gastric bypass: validation of the dumping symptom rating scale. ( 23315151 )
2013
41
Laparoscopic conversion of laparoscopic Roux-en-Y gastric bypass to laparoscopic sleeve gastrectomy for intractable dumping syndrome and excessive weight loss. ( 23369599 )
2013
42
Early dumping syndrome and reflux esophagitis prevention with pouch reconstruction. ( 21492874 )
2012
43
Symptoms suggestive of dumping syndrome after provocation in patients after laparoscopic sleeve gastrectomy. ( 21647622 )
2012
44
Successful treatment of reactive hypoglycemia secondary to late dumping syndrome using miglitol. ( 22989830 )
2012
45
Medical complications of bariatric surgery: focus on malabsorption and dumping syndrome. ( 22722436 )
2012
46
Dumping syndrome, a cause of acquired glycogenic hepatopathy. ( 21338321 )
2011
47
Dumping syndrome following nissen fundoplication in an adult patient diagnosed by continuous online 13C/12C monitoring of A^A^C-Octanoic acid breath test "a case report". ( 21929798 )
2011
48
Safety and efficacy of high-dose acarbose treatment for dumping syndrome. ( 21694549 )
2011
49
Dumping syndrome: an unusual cause of severe hyperinsulinemic hypoglycemia in neurologically impaired children with gastrostomy. ( 21311431 )
2011
50
Dumping syndrome after esophageal atresia repair without antireflux surgery. ( 20385264 )
2010

Variations for Dumping Syndrome

Expression for Dumping Syndrome

Search GEO for disease gene expression data for Dumping Syndrome.

Pathways for Dumping Syndrome

Pathways related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 GCG GIP INS NTS PYY SCT
2
Show member pathways
12.37 GCG GIP NTS PYY SCT SST
3
Show member pathways
11.9 GCG GIP SCT
4
Show member pathways
11.69 GCG GIP INS
5 11.3 GCG GIP SCT
6
Show member pathways
11.15 GCG GIP
7
Show member pathways
11.03 GCG INS

GO Terms for Dumping Syndrome

Cellular components related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 GCG GIP INS
2 extracellular space GO:0005615 9.43 GCG GIP INS PYY SCT SST
3 secretory granule lumen GO:0034774 9.33 GCG GIP INS
4 transport vesicle GO:0030133 9.32 INS NTS
5 extracellular region GO:0005576 9.17 GCG GIP INS NTS PYY SCT

Biological processes related to Dumping Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.61 INS PYY SST
2 G-protein coupled receptor signaling pathway GO:0007186 9.5 GCG GIP INS NTS PYY SCT
3 response to glucose GO:0009749 9.49 GIP INS
4 regulation of insulin secretion GO:0050796 9.48 GCG GIP
5 response to nutrient levels GO:0031667 9.46 GIP INS
6 feeding behavior GO:0007631 9.4 GCG PYY
7 response to amino acid GO:0043200 9.37 GIP SST
8 response to starvation GO:0042594 9.32 GCG GIP
9 positive regulation of cAMP-mediated signaling GO:0043950 9.26 GIP SCT
10 regulation of signaling receptor activity GO:0010469 9.17 GCG GIP INS NTS PYY SCT
11 response to acidic pH GO:0010447 9.16 GIP SST

Molecular functions related to Dumping Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor binding GO:0001664 9.16 PYY SCT
2 hormone activity GO:0005179 9.1 GCG GIP INS PYY SCT SST
3 neuropeptide hormone activity GO:0005184 8.96 NTS PYY

Sources for Dumping Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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