Duodenal Atresia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DDN011 MIFTS: 48	Duodenal Atresia Categories: Fetal diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Duodenal Atresia

MalaCards integrated aliases for Duodenal Atresia:

Name: Duodenal Atresia ⁵⁷ ¹² ⁷⁴ ²⁰ ⁵⁸ ²⁹ ⁶ ¹⁵

Duodenal Stenosis ²⁰ ²⁹ ⁵⁴ ⁶

Familial Duodenal Atresia ⁴⁴

Characteristics:

Orphanet epidemiological data:

⁵⁸

duodenal atresia
Inheritance: Autosomal recessive; Prevalence: 1-9/100000 (Europe),1-9/100000 (Belgium),1-9/100000 (Spain),1-9/100000 (Ireland),1-9/100000 (Italy),1-5/10000 (United Kingdom),1-9/100000 (Malta),1-9/100000 (Denmark),1-5/10000 (France),1-9/100000 (Reunion),1-9/100000 (Portugal),1-9/100000 (Germany),1-9/100000 (Austria),1-9/100000 (Switzerland); Age of onset: Antenatal,Childhood,Infancy,Neonatal;

OMIM®:

⁵⁷ (Updated 05-Mar-2021)

Inheritance:
autosomal recessive

HPO:

³¹

duodenal atresia:
Inheritance autosomal recessive inheritance

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases Genetic diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Congenital malformations, deformations and chromosomal abnormalities

Other congenital malformations of the digestive system

Congenital absence, atresia and stenosis of small intestine

Congenital absence, atresia and stenosis of duodenum

Orphanet: ⁵⁸

Developmental anomalies during embryogenesis

External Ids:

Disease Ontology ¹² DOID:0080216

OMIM® ⁵⁷ 223400

MeSH ⁴⁴ C535720

MESH via Orphanet ⁴⁵ C535720

ICD10 via Orphanet ³³ Q41.0

UMLS via Orphanet ⁷² C0266174

Orphanet ⁵⁸ ORPHA1203

MedGen ⁴¹ C0266174

SNOMED-CT via HPO ⁶⁸ 128588008 198914002 258211005 more

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Summaries for Duodenal Atresia

GARD : ²⁰ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 1203DefinitionDuodenal atresia is an embryopathy of the cranial intestine that leads to a complete absence of the duodenal lumen.EpidemiologyThe incidence of duodenal atresia is between 1/10,000 and 1/6,000 live births, with an approximately equal male to female ratio.Clinical descriptionIn 30-52% of infants it is an isolated anomaly, but it is often associated with other congenital abnormalities. Approximately 20 to 30% of infants with duodenal atresia are carriers of trisomy 21, and about 20 to 25% have cardiac anomalies. Other frequently described associated malformations include duodenal growth failure, annular pancreas (see this term), which are particular clinical forms of duodenal atresia, and anomalies of the biliopancreatic tract or choledochal cysts. Duodenal atresia is classified into three types: type I (duodenal diaphragm) is linked to the presence of a mucosal diaphragmatic membrane with an intact muscle wall; type II (complete a duodenal atresia) characterized by a short fibrous cord connecting the two ends of the atresic duodenum; and type III (also complete duodenal atresia) which corresponds to a complete separation of the two ends of the duodenum, sometimes together with annular pancreas. Clinical presentation depends on the degree of atresia. Important obstructions manifest during the first days of life with bilious vomiting if the obstacle is infra-vaterian, which starts in the hours after birth, and with feeding intolerance. Weight loss, dehydration, and hypochloremic metabolic alkalosis are the most common symptoms. Less severe obstructions may manifest several months, or even several years, after birth with bilious vomiting without abdominal distention (major sign); however, failure to thrive may be the only presentation.EtiologyVascular anomalies, abnormalities in neural cell migration and failure of recanalization of the duodenal lumen may play a causative role, although the exact cause remains unknown.Diagnostic methodsThe clinical diagnosis is confirmed by abdominal radiography that shows a characteristic 'double bubble'' appearance with air trapped in the first portion of the duodenum and stomach due to the simultaneous distension of the stomach and first portion of the duodenum (above the stenosis).Differential diagnosisDifferential diagnoses include late appearing pyloric stenosis in cases of incomplete diaphragm, and other forms of intestinal atresia, common mesenteric intestinal volvulus, and duodenal duplication.Antenatal diagnosisDiagnosis is prenatal in 80-90% of cases (by ultrasound in the seventh month or before that reveals the characteristic ``double bubble'' image).Genetic counselingIn most cases, duodenal atresia is sporadic, although an autosomal recessive pattern has been suggested in some families.Management and treatmentManagement involves neonatal resuscitation and surgical correction in the neonatal period. Post-operative complications are rare, but late complications (megaduodenum, blind loop syndrome, duodenogastric reflux, esophagitis, pancreatitis, cholecystitis and cholelithiasis) occur in very rare cases.PrognosisThe prognosis with early surgical intervention is excellent.Visit the Orphanet disease page for more resources.

MalaCards based summary : Duodenal Atresia, also known as duodenal stenosis, is related to pancreas, annular and intestinal atresia. An important gene associated with Duodenal Atresia is C12orf60 (Chromosome 12 Open Reading Frame 60), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Regulation of beta-cell development. Affiliated tissues include pancreas, small intestine and heart, and related phenotypes are polyhydramnios and duodenal atresia

Disease Ontology : ¹² An intestinal atresia that is characterized by congenital absence or complete closure of a portion of the lumen of the duodenum.

Wikipedia : ⁷⁴ Duodenal atresia is the congenital absence or complete closure of a portion of the lumen of the... more...

More information from OMIM: 223400

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Related Diseases for Duodenal Atresia

Diseases related to Duodenal Atresia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)

#	Related Disease	Score	Top Affiliating Genes
1	pancreas, annular	32.3	RFX6 FOXF1
2	intestinal atresia	30.6	RFX6 FOXF1 FGF10
3	volvulus of midgut	30.4	GUCY2C FOXF1
4	vater/vacterl association	30.1	ZIC3 FOXF1
5	meconium ileus	30.0	GUCY2C CFTR C12orf60
6	anus, imperforate	29.9	ZIC3 FOXF1 FGF10
7	renal hypodysplasia/aplasia 1	29.6	ZIC3 HNF1B FOXF1 FGF10 CFTR
8	tetralogy of fallot	29.2	ZIC3 FOXF1 FMO5 FGF10
9	ventricular septal defect	28.9	ZIC3 FOXF1 FBN2
10	stromme syndrome	11.3
11	duodenal atresia tetralogy of fallot	11.2
12	feingold syndrome 1	11.1
13	pancreatic lipomatosis duodenal stenosis	11.1
14	down syndrome	10.5
15	duodenal obstruction	10.5
16	esophageal atresia	10.5
17	chromosomal triplication	10.5
18	intestinal obstruction	10.4
19	tracheoesophageal fistula with or without esophageal atresia	10.4
20	diarrhea 6	10.3	GUCY2C C12orf60
21	bile duct cysts	10.3
22	situs inversus	10.3
23	pancreatic agenesis 1	10.2	SCT CFTR
24	biliary atresia	10.2
25	spermatocele	10.2	CFTR AFP
26	biliary dyskinesia	10.2	SCT CFTR
27	pancreatic cancer	10.1
28	bile acid malabsorption, primary	10.1	SCT CFTR
29	jejunal atresia	10.1
30	microcephaly	10.1
31	polyhydramnios	10.1
32	aneurysm	10.1
33	gastroesophageal reflux	10.1
34	gastritis	10.1
35	pancreatitis	10.1
36	peptic ulcer disease	10.1
37	peritonitis	10.1
38	dextrocardia	10.1
39	cystic kidney disease	10.1	SCT HNF1B CFTR
40	gallbladder cancer	10.0
41	crohn's disease	10.0
42	obstructive hydrocephalus	10.0	RNU4ATAC AFP
43	polycystic liver disease	10.0	SCT HNF1B CFTR
44	diaphragmatic hernia, congenital	10.0
45	hernia, hiatus	10.0
46	polydactyly	10.0
47	gastrointestinal ulceration, recurrent, with dysfunctional platelets	10.0
48	pulmonary hypertension	10.0
49	cholelithiasis	10.0
50	hydronephrosis	10.0

Graphical network of the top 20 diseases related to Duodenal Atresia:

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Symptoms & Phenotypes for Duodenal Atresia

Human phenotypes related to Duodenal Atresia:

⁵⁸ ³¹

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	polyhydramnios ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001561
2	duodenal atresia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002247
3	abnormality of the pulmonary artery ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0004414
4	annular pancreas ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001734
5	abnormality of the pancreas ⁵⁸		Occasional (29-5%)

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Mar-2021)

G I:
duodenal atresia

Clinical features from OMIM®:

223400 (Updated 05-Mar-2021)

GenomeRNAi Phenotypes related to Duodenal Atresia according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased circadian period length	GR00213-A	8.8	FOXF1 GPR89B GUCY2C

MGI Mouse Phenotypes related to Duodenal Atresia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.93	CFTR COL5A1 FBN2 FGF10 FMO5 FOXF1
2	digestive/alimentary	MP:0005381	9.87	CFTR FGF10 FOXF1 GUCY2C ITGA6 RFX6
3	endocrine/exocrine gland	MP:0005379	9.86	AFP CFTR FGF10 FOXF1 GPR89B HNF1B
4	liver/biliary system	MP:0005370	9.5	AFP CFTR FBN2 FOXF1 GUCY2C HNF1B
5	mortality/aging	MP:0010768	9.4	AFP CFTR COL5A1 FBN2 FGF10 FOXF1

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Drugs & Therapeutics for Duodenal Atresia

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of the Efficacy of Duodenal Prostheses Not Covered Over 6 Years	Recruiting	NCT03463668
2	Validation of a Totally Synthetic High Fidelity Laparoscopic Duodenal Atresia (DA) Surgical Simulator	Recruiting	NCT04114279

Search NIH Clinical Center for Duodenal Atresia

Cochrane evidence based reviews: familial duodenal atresia

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Genetic Tests for Duodenal Atresia

Genetic tests related to Duodenal Atresia:

#	Genetic test	Affiliating Genes
1	Duodenal Atresia (disease) ²⁹
2	Duodenal Stenosis ²⁹

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Anatomical Context for Duodenal Atresia

MalaCards organs/tissues related to Duodenal Atresia:

⁴⁰

Pancreas, Small Intestine, Heart, Colon, Kidney, Lung, Liver

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Publications for Duodenal Atresia

Articles related to Duodenal Atresia:

(show top 50) (show all 1333)

#	Title	Authors	PMID	Year
1	Familial duodenal atresia: a report of two families and review. ⁶¹ ⁵⁷	Best LG...Chudley AE	2688422	1989
2	Letter: Familial congenital duodenal atresia (continued). ⁶¹ ⁵⁷	Der Kaloustian VM...Mishlany HG	4834311	1974
3	Familial congenital duodenal atresia. ⁵⁷ ⁶¹	Mishalany HG...Ghandour MH	5547883	1971
4	Familial congenital duodenal atresia. ⁵⁷ ⁶¹	Mishalany HG...Ghandour M	5503698	1970
5	Pyloroduodenal atresia (diaphragm type): an autosomal recessive disease. ⁵⁷	Mishalany HG...Der Kaloustian VM	704218	1978
6	Congenital atresia and stenosis of the duodenum. A review compiled from the members of the Surgical Section of the American Academy of Pediatrics. ⁵⁷	Fonkalsrud EW...Hays DM	4236815	1969
7	[Pseudo Zollinger-Ellison syndrome in a patient with duodenal stenosis caused by tuberculosis]. ⁶¹ ⁵⁴	Rautou PE...Ruszniewski P	16505764	2005
8	Diagnostic decision-making tool for imaging term neonatal bowel obstruction. ⁶¹	Tsitsiou Y...Andronikou S	33097229	2021
9	Anaesthesia for Antenatal Diagnosed Duodenal Atresia with Undiagnosed Persistent Pulmonary Hypertension of Neonate. ⁶¹	Yadav RK...Shrestha MK	33510531	2021
10	Delayed development of vacuoles and recanalization in the duodenum: a study in human fetuses to understand susceptibility to duodenal atresia/stenosis. ⁶¹	Liu X...Jin ZW	33511891	2021
11	Outcomes of both complex and isolated cases of infants with large stomach on fetal ultrasound. ⁶¹	McCormick BM...Jelin AC	33451621	2021
12	Congenital biliary dilatation appearing 3 years after the correction of duodenal atresia with pancreaticobiliary maljunction. ⁶¹	Yokoyama S...Nakaoka T	33201527	2020
13	A case of neonate effectively treated with everolimus for giant hepatic hemangioma complicated with congenital duodenal atresia and Kasabach-Merritt syndrome. ⁶¹	Watanabe S...Suzuki T	33325401	2020
14	Endoscopic ultrasound-guided gallbladder drainage in pancreatic cancer and cholangitis: A case report. ⁶¹	de Nucci G...Manes G	33269057	2020
15	Pancreatoduodenectomy for paraduodenal pancreatitis: a diagnostic and therapeutic challenge. ⁶¹	Jiang C...Wang M	33213250	2020
16	Appearance of fetal intestinal obstruction on fetal MRI. ⁶¹	Li X...Kefei H	32594545	2020
17	The value of saline-aided ultrasound in diagnosing congenital duodenal obstruction. ⁶¹	Yang B...Wang H	32715324	2020
18	Duodenal Atresia with Bifid Common Bile Duct. ⁶¹	Griggs C...Fallon E	32504618	2020
19	[Progress of research on induced pluripotent stem cell models for Down syndrome]. ⁶¹	Zhang T...Kong X	32924131	2020
20	Quality of life outcomes in children born with duodenal atresia. ⁶¹	Vinycomb T...Teague WJ	31955988	2020
21	Phenotypic expansion in Zhu-Tokita-Takenouchi-Kim syndrome caused by de novo variants in the SON gene. ⁶¹	Slezak R...Ploski R	32705777	2020
22	Duodenal Diverticulum as the Cause of Unexplained Duodenal Stenosis. ⁶¹	Thakran J...Adamek HE	33568262	2020
23	Endoscopic Ultrasound-guided Fine Needle Aspiration for the Diagnosis of Duodenal Stenosis Due to Urothelial Carcinoma. ⁶¹	Motoo I...Yasuda I	32963164	2020
24	Esophageal Atresia and Associated Duodenal Atresia: A Cohort Study and Review of the Literature. ⁶¹	Miscia ME...Lelli Chiesa P	32987434	2020
25	Endoscopic ultrasound-guided gallbladder drainage as a rescue therapy for unresectable malignant biliary obstruction: a multicenter experience. ⁶¹	Issa D...Sharaiha RZ	32898918	2020
26	Atypical extensive pancreatic pseudocyst with hemorrhage in a hemodialysis patient. ⁶¹	Taniguchi Y...Terada Y	32642008	2020
27	International consensus guidelines on interventional endoscopy in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club. ⁶¹	Kitano M...Whitcomb DC	32792253	2020
28	"The Hopkins Mongol Case": The Dawn of the Bioethics Movement. ⁶¹	Fost N	32737225	2020
29	Unique Case of Congenital Duodenal Atresia and a Choledochal Cyst and the Hypothesis of Their Embryological Evolution. ⁶¹	Downing B...Kylat RI	32824642	2020
30	Management of duodenal atresia associated with situs inversus abdominus: A case report. ⁶¹	Qiang S...Li F	32756156	2020
31	EUS-guided choledochoduodenostomy by use of electrocautery-enhanced lumen-apposing metal stents: a French multicenter study after implementation of the technique (with video). ⁶¹	Jacques J...Napoleon B	32084411	2020
32	Groove pancreatitis: a case report with a brief review of this diagnostic challenge. ⁶¹	Valentini G...Mazzucco D	32677417	2020
33	Relationship between papilla-related variables and post endoscopic retrograde cholangiopancreatography pancreatitis: A multicenter, prospective study. ⁶¹	Wang X...Wu K	32511794	2020
34	Duodenal Stenosis: A Diagnostic Challenge in a Neonate With Poor Weight Gain. ⁶¹	Win MKK...Adeyinka A	32670696	2020
35	A case of triple digestive tract reconstruction in chronic pancreatitis complicated with bile ductal stenosis, duodenal stenosis, and portal vein stenosis: a case report. ⁶¹	Abe Y...Endo I	32458256	2020
36	Sex differences in surgically correctable congenital anomalies: A systematic review. ⁶¹	Black AJ...Baird R	32061363	2020
37	Genetic counseling for fetal gastrointestinal anomalies. ⁶¹	Schindewolf E...Moldenhauer JS	32039977	2020
38	Obstructive jaundice caused by ulcerative duodenal stenosis: A case report. ⁶¹	Chen L...Liu Z	32246671	2020
39	Clinical data and Pediatric Quality of Life Inventory (PedsQL™) scores for children with duodenal atresia. ⁶¹	Vinycomb TI...Teague WJ	32055666	2020
40	Congenital duodenal obstruction in the UK: a population-based study. ⁶¹	Bethell GS...BAPS-CASS	31229958	2020
41	Adolescent with Superior Mesenteric Artery Syndrome. ⁶¹	Ren PLJ...Gupta A	33082917	2020
42	Successful biliary self-expandable metallic stenting using an ultra-slim endoscope for cholangitis caused by pancreatic cancer. ⁶¹	Kida A...Sakai A	31585497	2020
43	Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis. ⁶¹	Olesen SS...Scandinavian Baltic Pancreatic Club	31314128	2020
44	Upper Gastrointestinal Bleed in a Young Male- A Rare Presentation of Eosinophilic Gastroenteritis. ⁶¹	Priyadarshni S...Patel N	32219053	2020
45	A rare combination of MODY5 and duodenal atresia in a patient: a case report. ⁶¹	Du T...Li W	32028929	2020
46	Potential Benefits of Laparoscopic Repair of Duodenal Atresia: Insights from a Retrospective Comparative Study. ⁶¹	Sidler M...De Coppi P	31707729	2020
47	The Double Bubble Sign: Duodenal Atresia and Associated Genetic Etiologies. ⁶¹	Bishop JC...Jelin AC	31167209	2020
48	The Role of Fibroblast Growth Factor 10 Signaling in Duodenal Atresia. ⁶¹	Jones MLM...Teague WJ	32210824	2020
49	Antenatal ultrasonography depicting congenital high airway obstruction syndrome with duodenal atresia. ⁶¹	Saran S...Khanna T	32528207	2020
50	Fatal Course of a Male Newborn with Double Duodenal Atresia. ⁶¹	Elrouby A...Koraitim A	32042546	2020

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Genes for Duodenal Atresia

Genes related to Duodenal Atresia (1 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	C12orf60	Chromosome 12 Open Reading Frame 60	Protein Coding	407.03	Pathogenic ⁶ GeneCards inferred via : Variants (show sections)
2	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	25	Likely pathogenic ⁶
3	ITGA6	Integrin Subunit Alpha 6	Protein Coding	12.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	HNF1B	HNF1 Homeobox B	Protein Coding	11.32	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	COL5A1	Collagen Type V Alpha 1 Chain	Protein Coding	10.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	RNU4ATAC	RNA, U4atac Small Nuclear (U12-Dependent Splicing)	RNA Gene	7.53	DISEASES inferred ¹⁵ ¹⁵
7	GUCY2C	Guanylate Cyclase 2C	Protein Coding	7.03	GeneCards inferred via : Variants (show sections)
8	FGF10	Fibroblast Growth Factor 10	Protein Coding	6.65	DISEASES inferred ¹⁵
9	RFX6	Regulatory Factor X6	Protein Coding	6.64	DISEASES inferred ¹⁵
10	FOXF1	Forkhead Box F1	Protein Coding	6.11	DISEASES inferred ¹⁵
11	SCT	Secretin	Protein Coding	5.96	Novoseek inferred ⁵⁴	16505764
12	NBPF11	NBPF Member 11	Protein Coding	5.79	DISEASES inferred ¹⁵
13	AFP	Alpha Fetoprotein	Protein Coding	5.58	DISEASES inferred ¹⁵
14	FBN2	Fibrillin 2	Protein Coding	5.54	DISEASES inferred ¹⁵
15	FMO5	Flavin Containing Dimethylaniline Monoxygenase 5	Protein Coding	5.54	DISEASES inferred ¹⁵
16	GPR89A	G Protein-Coupled Receptor 89A	Protein Coding	5.49	DISEASES inferred ¹⁵
17	GPR89B	G Protein-Coupled Receptor 89B	Protein Coding	5.48	DISEASES inferred ¹⁵
18	ZIC3	Zic Family Member 3	Protein Coding	5.47	DISEASES inferred ¹⁵

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Variations for Duodenal Atresia

ClinVar genetic disease variations for Duodenal Atresia:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	C12orf60	NM_004963.4(GUCY2C):c.410T>C (p.Leu137Ser)	SNV	Pathogenic	375380	rs1057519441	12:14836177-14836177	12:14683243-14683243
2	CFTR	NM_000492.3(CFTR):c.1521_1523delCTT (p.Phe508delPhe)	Deletion	Likely pathogenic	7105	rs113993960	7:117199645-117199647	7:117559591-117559593

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Expression for Duodenal Atresia

Search GEO for disease gene expression data for Duodenal Atresia.

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Pathways for Duodenal Atresia

Pathways related to Duodenal Atresia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.15	HNF1B FOXF1 FGF10 CFTR AFP
2	Regulation of beta-cell development ⁶⁵ Show member pathways Maturity onset diabetes of the young ³⁶ Regulation of gene expression in beta cells ⁶⁵ Regulation of gene expression in early pancreatic precursor cells ⁶⁵ Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells ⁶⁵ Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells ⁶⁵	11.13	RFX6 HNF1B FGF10

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GO Terms for Duodenal Atresia

Cellular components related to Duodenal Atresia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi-associated vesicle membrane	GO:0030660	8.62	GPR89A CFTR

Biological processes related to Duodenal Atresia according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.95	ZIC3 RFX6 ITGA6 HNF1B FOXF1 FGF10
2	positive regulation of transcription, DNA-templated	GO:0045893	9.91	ZIC3 RFX6 HNF1B FOXF1 FGF10
3	extracellular matrix organization	GO:0030198	9.62	ITGA6 FOXF1 FBN2 COL5A1
4	endocrine pancreas development	GO:0031018	9.55	RFX6 HNF1B
5	inorganic anion transport	GO:0015698	9.54	GPR89B GPR89A
6	lung development	GO:0030324	9.54	ZIC3 FOXF1 FGF10
7	limb morphogenesis	GO:0035108	9.52	FGF10 FBN2
8	lung morphogenesis	GO:0060425	9.49	FOXF1 FGF10
9	epithelial tube branching involved in lung morphogenesis	GO:0060441	9.46	FOXF1 FGF10
10	smooth muscle cell differentiation	GO:0051145	9.43	FOXF1 FGF10
11	determination of left/right symmetry	GO:0007368	9.43	ZIC3 FOXF1 FGF10
12	embryonic digestive tract morphogenesis	GO:0048557	9.4	FOXF1 FGF10
13	intracellular pH reduction	GO:0051452	9.16	GPR89B GPR89A
14	pancreas development	GO:0031016	9.13	HNF1B FOXF1 FGF10
15	embryonic digestive tract development	GO:0048566	8.8	SCT FOXF1 FGF10

Molecular functions related to Duodenal Atresia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated anion channel activity	GO:0008308	8.62	GPR89B GPR89A

Sources

Sources for Duodenal Atresia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia