Aliases & Classifications for Duodenal Disease

MalaCards integrated aliases for Duodenal Disease:

Name: Duodenal Disease 12 15
Duodenal Diseases 55 44 73
Duodenum Disorder 12


External Ids:

Disease Ontology 12 DOID:4072
MeSH 44 D004378
SNOMED-CT 68 196598004 52182008
UMLS 73 C0013289

Summaries for Duodenal Disease

MalaCards based summary : Duodenal Disease, also known as duodenal diseases, is related to duodenitis and fungal esophagitis, and has symptoms including constipation and diarrhea. An important gene associated with Duodenal Disease is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways is Gastric acid production. The drugs Dexlansoprazole and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and liver.

Wikipedia : 76 The duodenum[help 1] is the first section of the small intestine in most higher vertebrates, including... more...

Related Diseases for Duodenal Disease

Diseases related to Duodenal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 duodenitis 31.1 ATP12A ATP4A
2 fungal esophagitis 10.7 ATP12A ATP4A
3 bladder calculus 10.7 ATP12A ATP4A
4 gastrointestinal neuroendocrine benign tumor 10.7 ATP12A ATP4A
5 neonatal candidiasis 10.7 ATP12A ATP4A
6 photoallergic dermatitis 10.7 ATP12A ATP4A
7 squamous papillomatosis 10.7 ATP12A ATP4A
8 acute laryngitis 10.7 ATP12A ATP4A
9 gastroduodenal crohn's disease 10.7 ATP12A ATP4A
10 gastric neuroendocrine neoplasm 10.7 ATP12A ATP4A
11 toxic megacolon 10.7 ATP12A ATP4A
12 aspiration pneumonitis 10.7 ATP12A ATP4A
13 postsurgical hypothyroidism 10.7 ATP12A ATP4A
14 gastric antral vascular ectasia 10.7 ATP12A ATP4A
15 esophageal candidiasis 10.7 ATP12A ATP4A
16 rumination disorder 10.7 ATP12A ATP4A
17 granulomatous gastritis 10.7 ATP12A ATP4A
18 active peptic ulcer disease 10.7 ATP12A ATP4A
19 laryngeal disease 10.7 ATP12A ATP4A
20 ischemic neuropathy 10.7 ATP12A ATP4A
21 capillary disease 10.7 ATP12A ATP4A
22 peptic esophagitis 10.7 ATP12A ATP4A
23 dyskinesia of esophagus 10.7 ATP12A ATP4A
24 hernia, hiatus 10.7 ATP12A ATP4A
25 congenital disorder of deglycosylation 10.7 ATP12A ATP4A
26 anismus 10.7 ATP12A ATP4A
27 esophageal atresia/tracheoesophageal fistula 10.6 ATP12A ATP4A
28 laryngitis 10.6 ATP12A ATP4A
29 laryngeal tuberculosis 10.6 ATP12A ATP4A
30 lymphocytic colitis 10.6 ATP12A ATP4A
31 clostridium difficile colitis 10.6 ATP12A ATP4A
32 lower urinary tract calculus 10.6 ATP12A ATP4A
33 aspiration pneumonia 10.6 ATP12A ATP4A
34 diarrhea 1, secretory chloride, congenital 10.6 ATP12A ATP4A
35 chronic laryngitis 10.6 ATP12A ATP4A
36 chronic intestinal vascular insufficiency 10.6 ATP12A ATP4A
37 eosinophilic gastritis 10.6 ATP12A ATP4A
38 polyposis, skin pigmentation, alopecia, and fingernail changes 10.6 ATP12A ATP4A
39 esophageal varix 10.6 ATP12A ATP4A
40 esophagus adenocarcinoma 10.6 ATP12A ATP4A
41 myopathy, x-linked, with excessive autophagy 10.6 ATP12A ATP4A
42 gastric lymphoma 10.5 ATP12A ATP4A
43 pneumatosis cystoides intestinalis 10.5 ATP12A ATP4A
44 superior mesenteric artery syndrome 10.5 ATP12A ATP4A
45 jejunoileitis 10.5 ATP12A ATP4A
46 lateral medullary syndrome 10.5 ATP12A ATP4A
47 biliary dyskinesia 10.5 CCK SCT
48 paine syndrome 10.5 ATP12A ATP4A
49 esophagitis, eosinophilic, 1 10.5 ATP12A ATP4A
50 cloacal exstrophy 10.5 ATP12A ATP4A

Graphical network of the top 20 diseases related to Duodenal Disease:

Diseases related to Duodenal Disease

Symptoms & Phenotypes for Duodenal Disease

UMLS symptoms related to Duodenal Disease:

constipation, diarrhea

Drugs & Therapeutics for Duodenal Disease

Drugs for Duodenal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 230)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 138530-94-6, 103577-45-3 9578005
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
Lansoprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 103577-45-3 3883
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81103-11-9 84029
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 117976-89-3 5029
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73590-58-6 4594
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
Famotidine Approved Phase 4,Phase 3,Not Applicable 76824-35-6 3325
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 75614-87-8, 51-45-6 774
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 102625-70-7 4679
Clopidogrel Approved Phase 4,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
Ticlopidine Approved Phase 4,Phase 2,Not Applicable 55142-85-3 5472
Furazolidone Approved, Investigational, Vet_approved Phase 4,Not Applicable 67-45-8 3435 5323714
Tetracycline Approved, Vet_approved Phase 4,Not Applicable 60-54-8 5353990
Levofloxacin Approved, Investigational Phase 4,Not Applicable 100986-85-4 149096
Ofloxacin Approved Phase 4,Not Applicable 82419-36-1 4583
Celecoxib Approved, Investigational Phase 4,Phase 2,Phase 3 169590-42-5 2662
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
Potassium Citrate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable
Azithromycin Approved Phase 4 83905-01-5 55185 447043
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
Sulpiride Approved, Investigational Phase 4 15676-16-1 5355
Ranitidine Approved Phase 4,Phase 3,Phase 1 66357-59-3, 66357-35-5 3001055
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
Trimebutine Approved Phase 4 39133-31-8
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 77-92-9 311
31 Rebamipide Investigational Phase 4,Phase 3,Phase 2,Not Applicable 90098-04-7
32 Benzimidazole Experimental, Investigational Phase 4 51-17-2
Maleic acid Experimental Phase 4,Phase 1 110-16-7 444266
34 Antacids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
37 Proton Pump Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Not Applicable
39 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
40 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
41 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
42 Antiparasitic Agents Phase 4,Phase 2,Phase 3
43 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
44 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Antipyretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 330)
# Name Status NCT ID Phase Drugs
1 Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB) Unknown status NCT01123031 Phase 4 lansoprazole;esomeprazole
2 Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer Unknown status NCT00471029 Phase 4 esomeprazole
3 Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients Unknown status NCT02456012 Phase 4 oral esomeprazole 20 mg twice daily;oral esomeprazole 20 mg once daily
4 Helicobacter Pylori Empiric Treatment in Ulcer Bleeding Unknown status NCT00687336 Phase 4
5 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
6 Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis Unknown status NCT02759393 Phase 4 Dexlansoprazole;Lansoprazole
7 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
8 The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients Completed NCT02648659 Phase 4 Ilaprazole;Amoxicillin;Clarithromycin;Metronidazole
9 Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot Completed NCT02536989 Phase 4 omeprazole;omeprazole
10 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
11 A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers Completed NCT01353144 Phase 4 aspirin
12 Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion Completed NCT00843063 Phase 4 pantoprazole vs famotidine
13 The Dissemination of Consensus Recommendations on Upper Gastrointestinal Bleeding Completed NCT00840008 Phase 4
14 Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers Completed NCT00778193 Phase 4 Naproxen;Aspirin;Celecoxib;Clopidogrel;Placebo
15 Ulcer Prevention Study in Post Gastric Bypass Patients Completed NCT00557349 Phase 4 Omeprazole;Famotidine
16 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
17 Celebrex Low Dose ASA Study Examining the Incidence of Gastroduodenal Ulcers in a Healthy Population Completed NCT00137033 Phase 4 Celecoxib;Naproxen;ASA
18 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
19 The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia Completed NCT01822600 Phase 4 Human albumin;Omeprazole
20 The Efficacy of Double Doses of Oral Esomeprazole in Preventing Rebleeding for Patients With Bleeding Peptic Ulcers Completed NCT01591083 Phase 4 esomeprazole (Nexium®, AstraZeneca AB, Södertälje, Sweden)
21 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy Completed NCT02633930 Phase 4 Berberine;clarithromycin;Bismuth;Lansoprazole;amoxicillin
22 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy Completed NCT02296021 Phase 4 Berberine;Bismuth;esomeprazole;amoxicillin;clarithromycin
23 Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication Completed NCT02175901 Phase 4 Lansoprazole;Bismuth Potassium Citrate;Amoxicillin;Metronidazole;Clarithromycin
24 Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy Completed NCT00164866 Phase 4 Omeprazole
25 Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding Completed NCT00731601 Phase 4 pantoprazole;pantoprazole
26 Empirical Rescue Therapies of Helicobacter Pylori Infection Completed NCT01668927 Phase 4 Proton Pump Inhibitor;Bismuth;Metronidazole;Tetracycline;Furazolidone;Amoxicillin
27 Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment Completed NCT01667718 Phase 4 Bismuth;Lansoprazole;Levofloxacin;Amoxicillin
28 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
29 Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori Completed NCT01667575 Phase 4 Esomeprazole;Amoxicillin;Clarithromycin;Bismuth Potassium Citrate
30 Clarithromycin Resistant Tailored Therapy Completed NCT01453036 Phase 4
31 Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers Completed NCT00279123 Phase 4 pantoprazole infusion;pantoprazole bolus;no treatment
32 Vonoprazan Study of Investigating the Effect on Sleep Disturbance Associated With Reflux Esophagitis- Exploratory Evaluation Completed NCT03116841 Phase 4 Vonoprazan
33 A Study to Evaluate REbamiPide as an Adjuvant Regimen to Heal erosIve Reflux Esophagitis Completed NCT02755753 Phase 4 Lansoprazole;Rebamipide;Rebamipide-placebo
34 Healing Effects of Rebamipide and Omeprazole in Helicobacter Pylori-positive Gastric Ulcer After Eradication Therapy Completed NCT00272467 Phase 4 Rebamipide;Omeprazole
35 Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer Completed NCT00239551 Phase 4 Prevacid
36 Post-Marketing Clinical Study of Rebamipide in Patients With Gastric Ulcer Completed NCT00233389 Phase 4 Rebamipide
37 Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection Completed NCT00854451 Phase 4 omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin
38 A Double-blind, Comparative Study in Patients With Gastric Ulcer to Evaluate the Efficacy of Combination Use of E0671 and Rabeprazole Sodium Completed NCT00125736 Phase 4 Teprenone
39 The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD Completed NCT01860482 Phase 4 Newrabell® Tablet 10mg
40 An Open-label, Exploratory Trial to Assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium Completed NCT00428701 Phase 4 Esomeprazole Sodium
41 To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole Completed NCT01397084 Phase 4 esomeprazole 20 mg
42 Efficacy and Safety of Teprenone in Patients With Acute Gastritis, Acute Gastric Lesion of Chronic Gastritis With Acute Exacerbation or Gastric Ulcer Completed NCT01190657 Phase 4 Selbex;Selbex
43 An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis Completed NCT01008696 Phase 4 Rabeprazole;Lansoprazole
44 Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study Completed NCT00693225 Phase 4 Omeprazole/sodium bicarbonate
45 NEXIUM® in the Treatment of Moderate and Severe Erosive Esophagitis Completed NCT00206180 Phase 4 esomeprazole magnesium (oral medication)
46 Treatment of Zollinger-Ellison Syndrome With Prevacid Completed NCT00204373 Phase 4 Lansoprazole (Prevacid)
47 Effect of ALBIS on Gastroduodenal Mucosal Injury in Patients Receiving Dual Antiplatelet Therapy After Percutaneous Coronary Intervention Recruiting NCT02175186 Phase 4 ALBIS;Placebo
48 The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers Recruiting NCT03342456 Phase 4 Doxycycline Hyclate Enteric-Coated Capsules;Amoxicillin Capsules;Ilaprazole Enteric-Coated Tablets;Furazolidone Tablets;Potassium Citrate Tablets
49 Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole Recruiting NCT02986685 Phase 4 Trimebutine Maleate;rabeprazole
50 Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy Recruiting NCT01642875 Phase 4

Search NIH Clinical Center for Duodenal Disease

Cochrane evidence based reviews: duodenal diseases

Genetic Tests for Duodenal Disease

Anatomical Context for Duodenal Disease

MalaCards organs/tissues related to Duodenal Disease:

Testes, Small Intestine, Liver, Skin, Pancreas, Colon, Heart

Publications for Duodenal Disease

Articles related to Duodenal Disease:

(show all 15)
# Title Authors Year
Factors associated with gastro-duodenal disease in patients undergoing upper GI endoscopy at the Korle-Bu Teaching Hospital, Accra, Ghana. ( 27605979 )
A Case of Acute Esophageal Necrosis and Duodenal Disease in a Patient With Adrenal Insufficiency. ( 27392758 )
Diarrhoea and duodenal disease. Coeliac disease. ( 25107558 )
Association of genetic polymorphisms in IL17A and IL17F with gastro-duodenal diseases. ( 23012664 )
Advanced duodenal disease in familial adenomatous polyposis: how frequently should patients be followed up after successful therapy? ( 22760847 )
Toll-like receptor 2 (TLR) -196 to 174del polymorphism in gastro-duodenal diseases in Japanese population. ( 17934843 )
Pylorus-preserving pancreaticoduodenectomy for advanced duodenal disease in familial adenomatous polyposis (Br J Surg 2004; 91: 1157-1164). ( 15685693 )
Pylorus-preserving pancreaticoduodenectomy for advanced duodenal disease in familial adenomatous polyposis. ( 15449267 )
Helicobacter pylori infection and subsequent peptic duodenal disease among young adults. ( 10869336 )
Current concepts in the surgical management of multiple endocrine neoplasia type 1 pancreatic-duodenal disease. Results in the treatment of 40 patients with Zollinger-Ellison syndrome, hypoglycaemia or both. ( 9681848 )
Prevalence of Campylobacter pylori in esophagitis, gastritis, and duodenal disease. ( 2730254 )
Possible pathogenetic pathways of Campylobacter pylori in gastro-duodenal disease. ( 3166532 )
A radiological review of duodenal disease. ( 5314954 )
Why the infrequency of malignant duodenal disease? ( 13011426 )

Variations for Duodenal Disease

Expression for Duodenal Disease

Search GEO for disease gene expression data for Duodenal Disease.

Pathways for Duodenal Disease

Pathways related to Duodenal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.47 CCK SCT

GO Terms for Duodenal Disease

Biological processes related to Duodenal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell differentiation GO:0045596 9.46 NODAL SIX2
2 potassium ion import GO:0010107 9.43 ATP12A ATP4A
3 embryonic cranial skeleton morphogenesis GO:0048701 9.4 NODAL SIX2
4 ATP hydrolysis coupled proton transport GO:0015991 9.37 ATP12A ATP4A
5 anterior/posterior axis specification GO:0009948 9.32 NODAL SIX2
6 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
7 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
8 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Duodenal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Duodenal Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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