MCID: DDN002
MIFTS: 33

Duodenal Gastrinoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Duodenal Gastrinoma

MalaCards integrated aliases for Duodenal Gastrinoma:

Name: Duodenal Gastrinoma 12 15
Duodenal Gastrin-Producing Neuroendocrine Tumor 74
Duodenal G-Cell Gastrin Producing Tumor 12
Malignant Duodenal Gastrinoma 12
Gastrinoma of Duodenum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7959
NCIt 51 C5731
UMLS 74 C1333321

Summaries for Duodenal Gastrinoma

MalaCards based summary : Duodenal Gastrinoma, also known as duodenal gastrin-producing neuroendocrine tumor, is related to gastrinoma and autoimmune atrophic gastritis. An important gene associated with Duodenal Gastrinoma is MEN1 (Menin 1), and among its related pathways/superpathways are Dopaminergic Neurogenesis and Gastric acid production. Affiliated tissues include kidney and testes, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Duodenal Gastrinoma

Diseases related to Duodenal Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 gastrinoma 30.5 CHGA GAST MEN1 SCT SST
2 autoimmune atrophic gastritis 30.1 CHGA GAST
3 diarrhea 30.1 CCK GAST SST
4 atrophic gastritis 30.1 CHGA GAST SST
5 zollinger-ellison syndrome 30.0 CHGA GAST MEN1 SCT SST
6 multiple endocrine neoplasia, type i 29.9 CHGA GAST MEN1 SCT SST
7 gastric neuroendocrine neoplasm 29.9 CHGA GAST SST
8 neuroendocrine tumor 28.8 CCK CHGA ENO2 GAST GRP MEN1
9 pancreatic gastrinoma 10.4 MEN1 SCT
10 chondroid lipoma 10.4 ENO2 MEN1
11 hormone producing pituitary cancer 10.4 MEN1 SST
12 mongolian spot 10.4 ENO2 SST
13 retroperitoneal neuroblastoma 10.3 ENO2 SST
14 angiodysplasia 10.3 SCT SST
15 biliary dyskinesia 10.3 CCK SCT
16 multiple endocrine neoplasia 10.3
17 dumping syndrome 10.3 SCT SST
18 intestinal neuroendocrine benign tumor 10.3 HMX1 MEN1 SCT
19 small intestine neuroendocrine neoplasm 10.3 HMX1 MEN1 SCT
20 functioning pituitary adenoma 10.3 MEN1 SST
21 cerebellum cancer 10.3 ENO2 SHH
22 gastritis 10.3
23 pancreatic steatorrhea 10.3 CCK SCT
24 intracranial primitive neuroectodermal tumor 10.3 CHGA ENO2
25 lung meningioma 10.3 ENO2 GRP
26 auditory system cancer 10.2 CHGA ENO2
27 small intestine cancer 10.2 MEN1 SCT SST
28 small cell carcinoma of the bladder 10.2 CHGA ENO2
29 epithelioid malignant peripheral nerve sheath tumor 10.2 CHGA ENO2
30 lung oat cell carcinoma 10.2 CHGA ENO2
31 pulmonary large cell neuroendocrine carcinoma 10.2 CHGA ENO2
32 large cell neuroendocrine carcinoma 10.2 CHGA ENO2
33 gallbladder small cell carcinoma 10.2 CHGA ENO2
34 atypical follicular adenoma 10.2 CHGA ENO2
35 duodenum cancer 10.2 ENO2 MEN1 SST
36 cauda equina neoplasm 10.2 CHGA ENO2
37 acute thyroiditis 10.2 CHGA ENO2
38 olfactory nerve neoplasm 10.2 CHGA ENO2
39 hemopneumothorax 10.2 CTSL SST
40 gastrointestinal neuroendocrine tumor 10.2 CHGA SST
41 autonomic nervous system benign neoplasm 10.2 CHGA ENO2
42 tanycytic ependymoma 10.2 CHGA MEN1
43 nodular ganglioneuroblastoma 10.2 CHGA ENO2
44 ectopic cushing syndrome 10.2 MEN1 SST
45 pineocytoma 10.2 CHGA ENO2
46 gastric gastrinoma 10.2 ENO2 GAST
47 meningioma, familial 10.2 ENO2 MEN1 SST
48 gastric small cell carcinoma 10.2 CHGA ENO2
49 subependymoma 10.2 CHGA ENO2
50 maturity-onset diabetes of the young, type 7 10.2 CCK HMX1 SCT

Graphical network of the top 20 diseases related to Duodenal Gastrinoma:



Diseases related to Duodenal Gastrinoma

Symptoms & Phenotypes for Duodenal Gastrinoma

MGI Mouse Phenotypes related to Duodenal Gastrinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 ENO2 GRP HMX1 HPRT1 PPY SHH
2 growth/size/body region MP:0005378 9.91 CHGA ENO2 HMX1 HPRT1 MEN1 PPY
3 nervous system MP:0003631 9.85 CCK CHGA ENO2 GRP HMX1 HPRT1
4 digestive/alimentary MP:0005381 9.8 GAST HPRT1 MEN1 SHH SLC18A2 SST
5 no phenotypic analysis MP:0003012 9.43 CCK CHGA HMX1 HPRT1 SHH SST
6 taste/olfaction MP:0005394 8.92 ENO2 HPRT1 SHH SLC18A2

Drugs & Therapeutics for Duodenal Gastrinoma

Search Clinical Trials , NIH Clinical Center for Duodenal Gastrinoma

Genetic Tests for Duodenal Gastrinoma

Anatomical Context for Duodenal Gastrinoma

MalaCards organs/tissues related to Duodenal Gastrinoma:

42
Kidney, Testes

Publications for Duodenal Gastrinoma

Articles related to Duodenal Gastrinoma:

(show all 23)
# Title Authors Year
1
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis. ( 30531243 )
2019
2
Duodenal Gastrinoma Discovered on Evaluation for Incidental Gastric Carcinoid. ( 28300688 )
2017
3
Acute kidney injury following vomiting and diarrhea after endoscopy in a duodenal gastrinoma patient. ( 28070096 )
2017
4
Diagnosis and preoperative tagging of duodenal gastrinoma by endoscopic ultrasound. ( 26492296 )
2015
5
Intraoperative near-infrared fluorescence visualization of theA duodenal gastrinoma in a patient withA Zollinger-Ellison syndrome. ( 26209566 )
2015
6
Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. ( 22580937 )
2013
7
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. ( 22588069 )
2012
8
Multiple giant duodenal ulcers associated with duodenal gastrinoma. ( 26181878 )
2012
9
An enucleated duodenal gastrinoma with multiple type 1 endocrine neoplasia located by selective arterial calcium injection. ( 21212598 )
2011
10
Duodenal gastrinoma: a diagnostic dilemma. ( 19233342 )
2009
11
Duodenal gastrinoma treated with endoscopic band ligation. ( 18926531 )
2009
12
Novel association of duodenal gastrinoma and atrophic gastritis: case report and literature review. ( 18194935 )
2007
13
Common bile duct obstruction due to a duodenal gastrinoma in a dog. ( 15993800 )
2005
14
Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor. ( 16253894 )
2005
15
Dual-phase multidetector thin-section CT in detecting duodenal gastrinoma. ( 15891805 )
2005
16
Duodenal gastrinoma--clinical features and usefulness of selective arterial secretin injection test. ( 9773940 )
1998
17
Brief report: a duodenal gastrinoma in a patient with diarrhea and normal serum gastrin concentrations. ( 7637724 )
1995
18
Duodenal gastrinoma: the solution to the pancreatic paradox. ( 7806825 )
1994
19
Endoscopic diagnosis and treatment of duodenal gastrinoma. ( 2227329 )
1990
20
Endoscopic diagnosis of a duodenal gastrinoma. ( 3181700 )
1988
21
Use of secretin in the roentgenologic and biochemical diagnosis of duodenal gastrinoma. ( 6837872 )
1983
22
Zollinger-Ellison syndrome treated by endoscopic removal of a duodenal gastrinoma. ( 732916 )
1978
23
Benign duodenal gastrinoma associated with the Zollinger-Ellison syndrome. ( 610461 )
1977

Variations for Duodenal Gastrinoma

Expression for Duodenal Gastrinoma

Search GEO for disease gene expression data for Duodenal Gastrinoma.

Pathways for Duodenal Gastrinoma

Pathways related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.43 SHH SLC18A2
2 9.77 CCK GAST GRP SCT

GO Terms for Duodenal Gastrinoma

Cellular components related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCK CHGA CTSL GAST GRP PPY
2 extracellular space GO:0005615 9.32 CCK CHGA CTSL ENO2 GAST GRP

Biological processes related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.63 CCK GAST GRP PPY SCT SST
2 response to amphetamine GO:0001975 9.37 HPRT1 SLC18A2
3 digestion GO:0007586 9.32 CCK SST
4 osteoblast development GO:0002076 9.26 MEN1 SHH
5 regulation of signaling receptor activity GO:0010469 9.17 CCK GAST GRP PPY SCT SHH
6 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway GO:1900738 8.96 CHGA GRP

Molecular functions related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.13 CCK GRP PPY
2 hormone activity GO:0005179 9.02 CCK GAST PPY SCT SST

Sources for Duodenal Gastrinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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