MCID: DDN002
MIFTS: 30

Duodenal Gastrinoma

Categories: Cancer diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Duodenal Gastrinoma

MalaCards integrated aliases for Duodenal Gastrinoma:

Name: Duodenal Gastrinoma 12 15
Duodenal Gastrin-Producing Neuroendocrine Tumor 70
Duodenal G-Cell Gastrin Producing Tumor 12
Malignant Duodenal Gastrinoma 12
Gastrinoma of Duodenum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7959
NCIt 50 C5731
UMLS 70 C1333321

Summaries for Duodenal Gastrinoma

MalaCards based summary : Duodenal Gastrinoma, also known as duodenal gastrin-producing neuroendocrine tumor, is related to gastrinoma and diarrhea. An important gene associated with Duodenal Gastrinoma is MEN1 (Menin 1), and among its related pathways/superpathways are Salivary secretion and G alpha (s) signalling events. Affiliated tissues include pituitary, thyroid and pancreas, and related phenotype is digestive/alimentary.

Related Diseases for Duodenal Gastrinoma

Diseases related to Duodenal Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 gastrinoma 30.6 SST SCT MEN1 GAST CHGA
2 diarrhea 30.5 SST SCT GAST
3 autoimmune atrophic gastritis 30.3 GAST CHGA
4 atrophic gastritis 30.1 SST MEN1 GAST CHGA
5 multiple endocrine neoplasia 29.8 SST SCT MEN1 GAST CHGA
6 gastric neuroendocrine neoplasm 29.8 SST MEN1 GAST CHGA
7 neuroendocrine carcinoma 29.7 SST MEN1 GAST CHGA
8 duodenal ulcer 29.4 SST SCT HRH2 GAST
9 multiple endocrine neoplasia, type i 29.1 SST SCT PPY MEN1 GCG GAST
10 zollinger-ellison syndrome 29.0 SST SCT MEN1 HRH2 GAST CHGA
11 neuroendocrine tumor 29.0 SST SCT MEN1 GCG GAST CHGA
12 gastritis 29.0 SST SCT HRH2 GAST CHGA ATP4A
13 pancreatic gastrinoma 27.4 SST SCT PPY MEN1 HRH2 GCG
14 rectum neuroendocrine neoplasm 10.2 SST GAST
15 pituitary infarct 10.2 SST MEN1
16 small intestine neuroendocrine neoplasm 10.2 SST MEN1
17 jejunal somatostatinoma 10.2 SST PPY
18 mixed ductal-endocrine carcinoma 10.2 GAST CHGA
19 hormone producing pituitary cancer 10.2 SST MEN1
20 goblet cell carcinoid 10.2 GAST CHGA
21 pituitary apoplexy 10.2 SST MEN1
22 pancreatic somatostatinoma 10.2 SST PPY
23 hyperpituitarism 10.2 SST MEN1
24 auditory system benign neoplasm 10.2 PPY CHGA
25 pituitary adenoma 1, multiple types 10.2 SST MEN1
26 middle ear adenoma 10.2 PPY CHGA
27 sensory organ benign neoplasm 10.2 PPY CHGA
28 pituitary tumors 10.2 SST MEN1
29 ampulla of vater benign neoplasm 10.2 SST CHGA
30 carotid body cancer 10.2 SST CHGA
31 duodenal benign neoplasm 10.2 SST CHGA
32 laryngeal neuroendocrine tumor 10.2 SST CHGA
33 ectopic cushing syndrome 10.2 SST CHGA
34 hypertrophic pyloric stenosis 10.2 SST GAST
35 persistent generalized lymphadenopathy 10.2 MEN1 CHGA
36 diamond-blackfan anemia 5 10.1 SST PPY
37 abnormality of glucagon secretion 10.1 SST GCG
38 binswanger's disease 10.1 SST CHGA
39 adrenal medulla cancer 10.1 SST CHGA
40 autonomic nervous system benign neoplasm 10.1 SST CHGA
41 peripheral nervous system benign neoplasm 10.1 SST CHGA
42 pancreatoblastoma 10.1 SST CHGA
43 angular cheilitis 10.1 SST GCG
44 hemangioma 10.1 MEN1 GAST CHGA
45 acinar cell carcinoma 10.1 GAST CHGA
46 functioning pituitary adenoma 10.1 SST MEN1
47 malignant pheochromocytoma 10.1 SST CHGA
48 adenoma 10.1 SST MEN1 CHGA
49 autonomic nervous system disease 10.1 PPY GCG
50 subependymal giant cell astrocytoma 10.0 SST CHGA

Graphical network of the top 20 diseases related to Duodenal Gastrinoma:



Diseases related to Duodenal Gastrinoma

Symptoms & Phenotypes for Duodenal Gastrinoma

MGI Mouse Phenotypes related to Duodenal Gastrinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 ATP12A ATP4A GAST HRH2 MEN1 SST

Drugs & Therapeutics for Duodenal Gastrinoma

Search Clinical Trials , NIH Clinical Center for Duodenal Gastrinoma

Genetic Tests for Duodenal Gastrinoma

Anatomical Context for Duodenal Gastrinoma

MalaCards organs/tissues related to Duodenal Gastrinoma:

40
Pituitary, Thyroid, Pancreas, Small Intestine, Lymph Node, Colon, Lung

Publications for Duodenal Gastrinoma

Articles related to Duodenal Gastrinoma:

(show top 50) (show all 68)
# Title Authors PMID Year
1
A Parathyroid-Gut Axis: Hypercalcemia and the Pathogenesis of Gastrinoma in Multiple Endocrine Neoplasia 1. 61
33771883 2021
2
Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report. 61
32337043 2020
3
[A case of difficult to diagnose duodenal gastrinoma]. 61
32779588 2020
4
Gastric Neuroendocrine Tumor and Duodenal Gastrinoma With Chronic Autoimmune Atrophic Gastritis. 61
30531243 2019
5
Prospective evaluation of 68 Ga-DOTATATE PET/CT in limited disease neuroendocrine tumours and/or elevated serum neuroendocrine biomarkers. 61
29788534 2018
6
Duodenal Gastrinoma Discovered on Evaluation for Incidental Gastric Carcinoid. 61
28300688 2017
7
Acute kidney injury following vomiting and diarrhea after endoscopy in a duodenal gastrinoma patient. 61
28070096 2017
8
Intraoperative near-infrared fluorescence visualization of the duodenal gastrinoma in a patient with Zollinger-Ellison syndrome. 61
26209566 2016
9
[Surgery for gastrinoma: Short and long-term results]. 61
25748044 2015
10
Impact of a novel 14 bp MEN1 deletion in a patient with hyperparathyroidism and gastrinoma. 61
26191410 2015
11
[Sporadic duodenal gastrinoma]. 61
27047628 2015
12
Diagnosis and preoperative tagging of duodenal gastrinoma by endoscopic ultrasound. 61
26492296 2015
13
Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome. 61
24363522 2013
14
Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. 61
22580937 2013
15
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. 61
22588069 2012
16
Multiple giant duodenal ulcers associated with duodenal gastrinoma. 61
26181878 2012
17
Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients. 61
21455335 2011
18
[About a case of multiple endocrine neoplasia type 1. Review of some clinical manifestations and treatment controversies]. 61
21339088 2011
19
An enucleated duodenal gastrinoma with multiple type 1 endocrine neoplasia located by selective arterial calcium injection. 61
21212598 2011
20
Recent standardization of treatment strategy for pancreatic neuroendocrine tumors. 61
20857521 2010
21
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. 61
19240184 2009
22
Duodenal gastrinoma: a diagnostic dilemma. 61
19233342 2009
23
Reoperative surgery in sporadic Zollinger-Ellison Syndrome: longterm results. 61
19476823 2009
24
Duodenal gastrinoma treated with endoscopic band ligation. 61
18926531 2009
25
Novel association of duodenal gastrinoma and atrophic gastritis: case report and literature review. 61
18194935 2007
26
Carcinogenic hypergastrinemia: signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome. 61
17609302 2007
27
Multiple carcinoids in the duodenum, pancreas and stomach accompanied with type A gastritis: a case report. 61
17465512 2007
28
Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor. 61
16253894 2005
29
Dual-phase multidetector thin-section CT in detecting duodenal gastrinoma. 61
15891805 2005
30
Common bile duct obstruction due to a duodenal gastrinoma in a dog. 61
15993800 2005
31
[A case of duodenal gastrinoma asymptomatically detected by medical health check]. 61
15981626 2005
32
Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. 61
15887103 2005
33
[Case of Zollinger-Ellison syndrome caused by duodenal gastrinoma presenting as refractory diarrhea and originally diagnosed by endoscopy]. 61
16004357 2005
34
[A case of Zollinger-Ellison syndrome due to duodenal gastrinoma with incurable diarrhea which was led to diagnosis by endoscopic examination]. 61
15529782 2004
35
[Metastatic duodenal gastrinoma and autoimmune atrophic chronic gastritis]. 61
14732854 2003
36
Management and outcome of patients with sporadic gastrinoma arising in the duodenum. 61
12832964 2003
37
Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: a prospective study. 61
12724631 2003
38
Radioguided surgery for gastrinoma: a case report. 61
12365386 2002
39
Comparison of surgical results in patients with advanced and limited disease with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome. 61
11573043 2001
40
A personal experience with pancreatic and duodenal neuroendocrine tumors. 61
10549736 1999
41
Intra-operative procedures to localize endocrine tumours of the pancreas and duodenum. 61
10604129 1999
42
Duodenal gastrinoma--clinical features and usefulness of selective arterial secretin injection test. 61
9773940 1998
43
Management of the Zollinger-Ellison syndrome in patients with multiple endocrine neoplasia type 1. 61
9681846 1998
44
[Posterior resection of of the head of the pancreas in malignant duodenal gastrinoma]. 61
9206639 1997
45
Gastrointestinal endocrine tumours. Pathology. 61
9113312 1996
46
Preferential localization of regional metastases from gastroenteropancreatic endocrine tumors with somatostatin-receptor scintigraphy. 61
8956777 1996
47
Preoperative detection of duodenal gastrinomas and peripancreatic lymph nodes by somatostatin receptor scintigraphy. Groupe D'etude Du Syndrome De Zollinger-Ellison. 61
8831579 1996
48
Brief report: a duodenal gastrinoma in a patient with diarrhea and normal serum gastrin concentrations. 61
7637724 1995
49
Duodenal gastrinoma: the solution to the pancreatic paradox. 61
7806825 1994
50
[Duodenal gastrinoma with the development of Zollinger-Ellison syndrome]. 61
8037598 1994

Variations for Duodenal Gastrinoma

Expression for Duodenal Gastrinoma

Search GEO for disease gene expression data for Duodenal Gastrinoma.

Pathways for Duodenal Gastrinoma

Pathways related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 SST SCT HRH2 GAST ATP4A
2 11.6 SCT HRH2 GCG
3 10.97 HRH2 ATP4A
4 10 SCT GAST
5 9.5 HRH2 GAST ATP4A

GO Terms for Duodenal Gastrinoma

Cellular components related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 SST SCT PPY GCG GAST CHGA
2 extracellular space GO:0005615 9.17 SST SCT PPY GCG GAST CHGA

Biological processes related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.4 ATP4A ATP12A
2 feeding behavior GO:0007631 9.37 PPY GCG
3 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.26 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 9.16 ATP4A ATP12A
6 G protein-coupled receptor signaling pathway GO:0007186 9.1 SST SCT PPY HRH2 GCG GAST
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.96 ATP4A ATP12A

Molecular functions related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
3 hormone activity GO:0005179 9.02 SST SCT PPY GCG GAST
4 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A

Sources for Duodenal Gastrinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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