MCID: DDN002
MIFTS: 33

Duodenal Gastrinoma

Categories: Cancer diseases, Gastrointestinal diseases, Endocrine diseases, Neuronal diseases

Aliases & Classifications for Duodenal Gastrinoma

MalaCards integrated aliases for Duodenal Gastrinoma:

Name: Duodenal Gastrinoma 12 15
Duodenal Gastrin-Producing Neuroendocrine Tumor 73
Duodenal G-Cell Gastrin Producing Tumor 12
Malignant Duodenal Gastrinoma 12
Gastrinoma of Duodenum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7959
NCIt 50 C5731
UMLS 73 C1333321

Summaries for Duodenal Gastrinoma

MalaCards based summary : Duodenal Gastrinoma, also known as duodenal gastrin-producing neuroendocrine tumor, is related to pancreatitis and gastrinoma. An important gene associated with Duodenal Gastrinoma is MEN1 (Menin 1), and among its related pathways/superpathways are Dopaminergic Neurogenesis and Gastric acid production. Affiliated tissues include testes and kidney, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Duodenal Gastrinoma

Diseases related to Duodenal Gastrinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 pancreatitis 30.5 CCK SCT SST
2 gastrinoma 30.0 CHGA GAST MEN1 SCT SST
3 diarrhea 30.0 CCK GAST SST
4 atrophic gastritis 29.7 CHGA GAST SST
5 zollinger-ellison syndrome 29.4 CHGA GAST MEN1 SCT SST
6 multiple endocrine neoplasia, type i 29.0 CHGA GAST MEN1 SCT SST
7 duodenal ulcer 28.0 CCK GAST GRP SCT SST
8 neuroendocrine tumor 27.7 CHGA ENO2 GAST GRP MEN1 SST
9 hormone producing pituitary cancer 10.8 MEN1 SST
10 chondroid lipoma 10.8 ENO2 MEN1
11 retroperitoneal neuroblastoma 10.8 ENO2 SST
12 angiodysplasia 10.7 SCT SST
13 dumping syndrome 10.7 SCT SST
14 biliary dyskinesia 10.7 CCK SCT
15 cerebellum cancer 10.7 ENO2 SHH
16 functioning pituitary adenoma 10.7 MEN1 SST
17 duodenal disease 10.7 CCK SCT
18 ureter small cell carcinoma 10.6 CHGA ENO2
19 intracranial primitive neuroectodermal tumor 10.6 CHGA ENO2
20 auditory system cancer 10.6 CHGA ENO2
21 gallbladder small cell carcinoma 10.6 CHGA ENO2
22 pancreatic gastrinoma 10.6 MEN1 SCT SST
23 small cell carcinoma of the bladder 10.6 CHGA ENO2
24 epithelioid malignant peripheral nerve sheath tumor 10.6 CHGA ENO2
25 pulmonary large cell neuroendocrine carcinoma 10.6 CHGA ENO2
26 atypical follicular adenoma 10.6 CHGA ENO2
27 adenoma of the pancreas 10.6 CHGA SST
28 olfactory nerve neoplasm 10.6 CHGA ENO2
29 pancreatic steatorrhea 10.6 CCK SCT
30 gastric gastrinoma 10.6 ENO2 GAST
31 cauda equina neoplasm 10.6 CHGA ENO2
32 duodenitis 10.6
33 acute thyroiditis 10.6 CHGA ENO2
34 tanycytic ependymoma 10.6 CHGA MEN1
35 gastrointestinal neuroendocrine tumor 10.6 CHGA SST
36 nodular ganglioneuroblastoma 10.6 CHGA ENO2
37 pineocytoma 10.5 CHGA ENO2
38 duodenum cancer 10.5 ENO2 MEN1 SST
39 respiratory system benign neoplasm 10.5 CHGA ENO2
40 gastric small cell carcinoma 10.5 CHGA ENO2
41 organ system benign neoplasm 10.5 ENO2 MEN1 SST
42 pituitary carcinoma 10.5 CHGA SST
43 subependymoma 10.5 CHGA ENO2
44 pylorospasm 10.5 GAST SST
45 papillary ependymoma 10.5 CHGA ENO2
46 pancreatoblastoma 10.5 CHGA SST
47 mucinous ovarian cystadenoma 10.5 ENO2 GAST
48 sclerosing hemangioma 10.5 CHGA ENO2
49 central neurocytoma 10.4 CHGA ENO2
50 diphyllobothriasis 10.4 GAST SCT

Graphical network of the top 20 diseases related to Duodenal Gastrinoma:



Diseases related to Duodenal Gastrinoma

Symptoms & Phenotypes for Duodenal Gastrinoma

MGI Mouse Phenotypes related to Duodenal Gastrinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 CCK PPY ENO2 SHH GRP HMX1
2 growth/size/body region MP:0005378 9.96 MEN1 PBX2 CHGA PPY ENO2 SHH
3 digestive/alimentary MP:0005381 9.87 PBX2 SHH GAST SLC18A2 SST HPRT1
4 craniofacial MP:0005382 9.85 MEN1 PBX2 ENO2 SHH HMX1 HPRT1
5 nervous system MP:0003631 9.85 CCK PBX2 ENO2 SHH GRP HMX1
6 no phenotypic analysis MP:0003012 9.43 CCK CHGA SHH HMX1 SST HPRT1
7 taste/olfaction MP:0005394 8.92 ENO2 SHH SLC18A2 HPRT1

Drugs & Therapeutics for Duodenal Gastrinoma

Search Clinical Trials , NIH Clinical Center for Duodenal Gastrinoma

Genetic Tests for Duodenal Gastrinoma

Anatomical Context for Duodenal Gastrinoma

MalaCards organs/tissues related to Duodenal Gastrinoma:

41
Testes, Kidney

Publications for Duodenal Gastrinoma

Articles related to Duodenal Gastrinoma:

(show all 27)
# Title Authors Year
1
Duodenal Gastrinoma Discovered on Evaluation for Incidental Gastric Carcinoid. ( 28300688 )
2017
2
Acute kidney injury following vomiting and diarrhea after endoscopy in a duodenal gastrinoma patient. ( 28070096 )
2017
3
Diagnosis and preoperative tagging of duodenal gastrinoma by endoscopic ultrasound. ( 26492296 )
2015
4
Intraoperative near-infrared fluorescence visualization of theA duodenal gastrinoma in a patient withA Zollinger-Ellison syndrome. ( 26209566 )
2015
5
Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. ( 22580937 )
2013
6
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. ( 22588069 )
2012
7
Multiple giant duodenal ulcers associated with duodenal gastrinoma. ( 26181878 )
2012
8
An enucleated duodenal gastrinoma with multiple type 1 endocrine neoplasia located by selective arterial calcium injection. ( 21212598 )
2011
9
Duodenal gastrinoma: a diagnostic dilemma. ( 19233342 )
2009
10
Duodenal gastrinoma treated with endoscopic band ligation. ( 18926531 )
2009
11
Novel association of duodenal gastrinoma and atrophic gastritis: case report and literature review. ( 18194935 )
2007
12
Common bile duct obstruction due to a duodenal gastrinoma in a dog. ( 15993800 )
2005
13
Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor. ( 16253894 )
2005
14
Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. ( 15887103 )
2005
15
Dual-phase multidetector thin-section CT in detecting duodenal gastrinoma. ( 15891805 )
2005
16
Duodenal gastrinoma--clinical features and usefulness of selective arterial secretin injection test. ( 9773940 )
1998
17
Pancreatic-polypeptide cell hyperplasia associated with pancreatic or duodenal gastrinomas. ( 9023394 )
1997
18
Brief report: a duodenal gastrinoma in a patient with diarrhea and normal serum gastrin concentrations. ( 7637724 )
1995
19
Duodenal gastrinoma: the solution to the pancreatic paradox. ( 7806825 )
1994
20
Duodenal gastrinomas, duodenotomy, and duodenal exploration in the surgical management of Zollinger-Ellison syndrome. ( 8103249 )
1993
21
Prospective study of the use of intraarterial secretin injection and portal venous sampling to localize duodenal gastrinomas. ( 1455303 )
1992
22
Location, incidence, and malignant potential of duodenal gastrinomas. ( 1745977 )
1991
23
Endoscopic diagnosis and treatment of duodenal gastrinoma. ( 2227329 )
1990
24
Endoscopic diagnosis of a duodenal gastrinoma. ( 3181700 )
1988
25
Use of secretin in the roentgenologic and biochemical diagnosis of duodenal gastrinoma. ( 6837872 )
1983
26
Zollinger-Ellison syndrome treated by endoscopic removal of a duodenal gastrinoma. ( 732916 )
1978
27
Benign duodenal gastrinoma associated with the Zollinger-Ellison syndrome. ( 610461 )
1977

Variations for Duodenal Gastrinoma

Expression for Duodenal Gastrinoma

Search GEO for disease gene expression data for Duodenal Gastrinoma.

Pathways for Duodenal Gastrinoma

Pathways related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.43 SHH SLC18A2
2 9.77 CCK GAST GRP SCT

GO Terms for Duodenal Gastrinoma

Cellular components related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCK CHGA CTSL GAST GRP PPY
2 extracellular space GO:0005615 9.32 CCK CHGA CTSL ENO2 GAST GRP

Biological processes related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.63 CCK GAST GRP PPY SCT SST
2 response to amphetamine GO:0001975 9.32 HPRT1 SLC18A2
3 osteoblast development GO:0002076 9.26 MEN1 SHH
4 regulation of signaling receptor activity GO:0010469 9.17 CCK GAST GRP PPY SCT SHH
5 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway GO:1900738 8.96 CHGA GRP

Molecular functions related to Duodenal Gastrinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.13 CCK GRP PPY
2 hormone activity GO:0005179 9.02 CCK GAST PPY SCT SST

Sources for Duodenal Gastrinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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