MCID: DDN009
MIFTS: 34

Duodenal Obstruction

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenal Obstruction

MalaCards integrated aliases for Duodenal Obstruction:

Name: Duodenal Obstruction 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3558
ICD10 33 K31.5
MeSH 44 D004380
NCIt 50 C79548
SNOMED-CT 68 95532008
UMLS 73 C0013292

Summaries for Duodenal Obstruction

MalaCards based summary : Duodenal Obstruction is related to lacrimoauriculodentodigital syndrome and pancreas, annular. An important gene associated with Duodenal Obstruction is HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta). The drugs Omeprazole and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Duodenal Obstruction

Diseases related to Duodenal Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 lacrimoauriculodentodigital syndrome 11.2
2 pancreas, annular 10.4
3 pancreatitis 10.4
4 aortic aneurysm 10.3
5 aortic aneurysm, familial abdominal, 1 10.3
6 situs inversus 10.2
7 pancreatic cancer 10.1
8 acute pancreatitis 10.1
9 fibrosclerosis, multifocal 10.0
10 retroperitoneal fibrosis 10.0
11 lymphoma 10.0
12 gastroenteritis 10.0
13 superior mesenteric artery syndrome 10.0
14 eosinophilic gastroenteritis 10.0
15 dextrocardia with situs inversus 10.0
16 eosinophilic enteropathy 10.0
17 breast cancer 9.9
18 diabetes mellitus, noninsulin-dependent 9.9
19 down syndrome 9.9
20 bile duct cysts 9.9
21 diabetes mellitus 9.9
22 appendicitis 9.9
23 septopreoptic holoprosencephaly 9.9 CDON NODAL
24 holoprosencephaly 9.9 CDON NODAL
25 midline interhemispheric variant of holoprosencephaly 9.9 CDON NODAL
26 alobar holoprosencephaly 9.9 CDON NODAL
27 lobar holoprosencephaly 9.8 CDON NODAL
28 intussusception 9.8
29 body mass index quantitative trait locus 11 9.8
30 body mass index quantitative trait locus 10 9.8
31 body mass index quantitative trait locus 14 9.8
32 body mass index quantitative trait locus 18 9.8
33 body mass index quantitative trait locus 19 9.8
34 b-cell lymphomas 9.8
35 cerebral palsy 9.8
36 omphalocele 9.8
37 blind loop syndrome 9.8
38 strongyloidiasis 9.8
39 hydronephrosis 9.8
40 sarcoma 9.8
41 obstructive jaundice 9.8
42 duodenal ulcer 9.8
43 adenocarcinoma 9.8
44 adenoma 9.8
45 fibromatosis 9.8
46 isolated levocardia 9.8
47 t-cell/histiocyte rich large b cell lymphoma 9.8
48 levocardia 9.8
49 microform holoprosencephaly 9.8 CDON NODAL
50 semilobar holoprosencephaly 9.7 CDON NODAL

Graphical network of the top 20 diseases related to Duodenal Obstruction:



Diseases related to Duodenal Obstruction

Symptoms & Phenotypes for Duodenal Obstruction

GenomeRNAi Phenotypes related to Duodenal Obstruction according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.66 NODAL
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.66 NDUFB4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.66 NDUFB4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.66 NODAL
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.66 FAM120A
6 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.66 FAM120A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.66 NODAL
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.66 FAM120A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.66 NDUFB4 NODAL
10 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.66 NDUFB4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.66 FAM120A NDUFB4 NODAL
12 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.66 NDUFB4 NODAL
13 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.66 FAM120A NDUFB4
14 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.66 NODAL
15 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.66 FAM120A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 NDUFB4
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.66 FAM120A

Drugs & Therapeutics for Duodenal Obstruction

Drugs for Duodenal Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
2
Ticlopidine Approved Phase 3 55142-85-3 5472
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
5 Purinergic P2Y Receptor Antagonists Phase 3
6 Neurotransmitter Agents Phase 3
7 Proton Pump Inhibitors Phase 3
8 Platelet Aggregation Inhibitors Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Antipyretics Phase 3
11 Purinergic P2 Receptor Antagonists Phase 3
12 Gastrointestinal Agents Phase 3
13 Analgesics Phase 3
14 Anti-Ulcer Agents Phase 3
15 Cytochrome P-450 Enzyme Inhibitors Phase 3
16 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Fibrinolytic Agents Phase 3
19 Antacids Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Cyclooxygenase Inhibitors Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Antirheumatic Agents Phase 3
24 Cola Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
2 Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction Completed NCT00004910 Phase 1, Phase 2
3 Endoscopic Gastroenteric Anastomosis With New Tissue Apposing Stent in the Management of Antro-pyloroduodenal Obstruction : Evaluation of Feasibility, Efficacy and Tolerance. Unknown status NCT02562157 Not Applicable
4 EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms Completed NCT00991614
5 SMAS: a Prospective Study in a Single Institution Completed NCT03416647 Not Applicable
6 Comparison of Duodenal Stenting vs Transpyloric and Duodenal Stenting for Malignant Obstruction Recruiting NCT03125148 Not Applicable

Search NIH Clinical Center for Duodenal Obstruction

Cochrane evidence based reviews: duodenal obstruction

Genetic Tests for Duodenal Obstruction

Anatomical Context for Duodenal Obstruction

MalaCards organs/tissues related to Duodenal Obstruction:

41
Pancreas, Colon, Breast, Kidney, T Cells, Liver, B Cells

Publications for Duodenal Obstruction

Articles related to Duodenal Obstruction:

(show top 50) (show all 583)
# Title Authors Year
1
Gastric Outlet and Duodenal Obstruction as a Complication of Migrated Gastrostomy Tube: Report of Two Cases and Literature Review. ( 29511412 )
2018
2
Atypical perioperative management for duodenal obstruction in an infant with heterotaxy syndrome: a case report. ( 29479560 )
2018
3
Double Duodenal Atresia: An Extremely Rare Presentation of Duodenal Obstruction. ( 29314383 )
2018
4
Hepatobiliary and Pancreatic: Segmental arterial mediolysis of pancreaticoduodenal artery accompanied by acute pancreatitis and duodenal obstruction. ( 29691909 )
2018
5
Application of Jejunal Nutrient Tube in Congenital Duodenal Obstruction in Children. ( 29900152 )
2018
6
International study of endoscopic management of distal malignant biliary obstruction combined with duodenal obstruction. ( 28982258 )
2018
7
Neonatal echocardiogram in duodenal obstruction is unnecessary after normal fetal cardiac imaging. ( 29866484 )
2018
8
Aortoduodenal syndrome: a rare cause of duodenal obstruction in a patient with previous aortic aneurysm repair. ( 30225856 )
2018
9
Comment on "Renal abscess complicated by duodenal obstruction in a patient with obesity and type 2 diabetes mellitus treated with gliflozin". ( 30387451 )
2018
10
Comment on "Renal abscess complicated by duodenal obstruction in a patient with obesity and type 2 diabetes mellitus treated with gliflozin". Authors' reply. ( 30387452 )
2018
11
Renal abscess complicated by duodenal obstruction in a patient with obesity and type 2 diabetes mellitus treated with gliflozin. ( 30154396 )
2018
12
A Single Surgeon Laparoscopic Duodenoduodenostomy Case Series for Congenital Duodenal Obstruction in an Academic Setting. ( 30016184 )
2018
13
Adhering to quality medical care: a case report of upper gastrointestinal bleeding due to self-expandable metal stent placed for benign duodenal obstruction. ( 30094254 )
2018
14
Duodenal obstruction due to intramural haematoma as a complication of endoscopic biopsy. ( 30153947 )
2018
15
Rare cause of duodenal obstruction: Bouveret syndrome. ( 30216175 )
2018
16
Late Presentation of a Duodenal Obstruction in a Child with Failure to Thrive and Abdominal Pain. ( 30235489 )
2018
17
Acute mechanical duodenal obstruction due to giant hydronephrosis: an unusual cause of acute abdomen. ( 30344154 )
2018
18
Transanastomotic tubes reduce the cost of nutritional support in neonates with congenital duodenal obstruction. ( 30417229 )
2018
19
An Unusual Case of Intestinal Malrotation Causing Duodenal Obstruction by a Looped Appendix. ( 30429450 )
2018
20
Transition from Laparotomy to Laparoscopic Repair of Congenital Duodenal Obstruction in Neonates: Our Early Experience. ( 29018788 )
2017
21
Giant Omphalocele Complicated by Postoperative Duodenal Obstruction. ( 28164002 )
2017
22
Endoscopic biliary stent insertion through specialized duodenal stent for combined malignant biliary and duodenal obstruction facilitated by stent or PTBD guidance. ( 28685637 )
2017
23
Roux-en-Y duodenojejunostomy for surgical management of isolated duodenal obstruction due to chronic pancreatitis. ( 28189119 )
2017
24
Congenital Duodenal Obstruction, Situs Inversus Totalis, and Gastric Perforation in a Neonate. ( 28770132 )
2017
25
A Rare Cause of Duodenal Obstruction: Metastatic Parotid Mucoepidermoid Carcinoma. ( 28351791 )
2017
26
Severe muscle fasciculations and tremor in a cat with hypochloraemic metabolic alkalosis secondary to duodenal obstruction. ( 28491446 )
2017
27
A case report of duodenal obstruction due to retroperitoneal bleeding after the rupture of a lower pancreaticoduodenal artery aneurysm. ( 28381781 )
2017
28
A unique complication of self-expandable metal stent placement in malignant duodenal obstruction. ( 28928926 )
2017
29
Laparoscopic versus open surgery in management of congenital duodenal obstruction in neonates: a single-center experience with 112 cases. ( 28943138 )
2017
30
Unexpected cause for duodenal obstruction: Brunner's gland hyperplasia. ( 29449737 )
2017
31
Annular pancreas causing duodenal obstruction in an adult. ( 28500113 )
2017
32
Distal Duodenal Obstruction: a Surgical Enigma. ( 28659679 )
2017
33
Preduodenal Portal Vein Associated with Duodenal Obstruction of other Etiology: A Case Series. ( 27896162 )
2016
34
An Unusual Cause of Duodenal Obstruction: Persimmon Phytobezoar. ( 28100951 )
2016
35
Association Between Prenatal Sonographic Findings of Duodenal Obstruction and Adverse Outcomes. ( 27466262 )
2016
36
Single-session double-stent placement in concomitant malignant biliary and duodenal obstruction with a cautery-tipped lumen apposing metal stent. ( 27706541 )
2016
37
Congenital duodenal obstruction with delayed presentation: seven years of experience. ( 27695493 )
2016
38
Neonatal Duodenal Obstruction: A 15-Year Experience. ( 27123397 )
2016
39
Congenital duodenal obstruction: causes and imaging approach. ( 27324508 )
2016
40
Palliation double stenting for malignant biliary and duodenal obstruction. ( 26889267 )
2016
41
Preduodenal Portal Vein with Situs Inversus Totalis causing Duodenal Obstruction. ( 27398325 )
2016
42
Temporary duodenal stenting as a bridge to ERCP for inaccessible papilla due to duodenal obstruction: a retrospective study. ( 27652301 )
2016
43
Congenital Duodenal Obstruction in Neonates: Over 13 Years' Experience from a Single Centre. ( 27896158 )
2016
44
Duodenal obstruction due to annular pancreas associated with carcinoma of the duodenum. ( 27350844 )
2016
45
Endoscopic choledochoduodenostomy and gastrojejunostomy in the treatment of biliary and duodenal obstruction. ( 26684602 )
2016
46
Laparoscopic repair of congenital duodenal obstruction is feasible even in small-volume centres. ( 27652789 )
2016
47
Two Cases of Intraluminal "Windsock" Diverticula Resulting in Partial Duodenal Obstruction. ( 27807587 )
2016
48
Is laparoscopic surgery better than open surgery for the repair of congenital duodenal obstruction? A review of the current evidences. ( 27622585 )
2016
49
Intestinal malrotation associated with duodenal obstruction secondary to Ladd's bands. ( 27777485 )
2016
50
Duodenal Obstruction Caused by an Annular Pancreas - Sonographic Diagnosis in a 4-Month-Old Dystrophic Infant. ( 27529456 )
2016

Variations for Duodenal Obstruction

Expression for Duodenal Obstruction

Search GEO for disease gene expression data for Duodenal Obstruction.

Pathways for Duodenal Obstruction

GO Terms for Duodenal Obstruction

Biological processes related to Duodenal Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 8.96 CDON NODAL
2 lens development in camera-type eye GO:0002088 8.62 CDON NHS

Sources for Duodenal Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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