MCID: DDN009
MIFTS: 33

Duodenal Obstruction

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenal Obstruction

MalaCards integrated aliases for Duodenal Obstruction:

Name: Duodenal Obstruction 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3558
MeSH 44 D004380
NCIt 50 C79548
SNOMED-CT 67 95532008
ICD10 32 K31.5
UMLS 70 C0013292

Summaries for Duodenal Obstruction

MalaCards based summary : Duodenal Obstruction is related to pancreatitis, hereditary and pancreas, annular. An important gene associated with Duodenal Obstruction is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit). The drugs Omeprazole and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and small intestine.

Related Diseases for Duodenal Obstruction

Diseases related to Duodenal Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 401)
# Related Disease Score Top Affiliating Genes
1 pancreatitis, hereditary 31.4 SPINK1 SCT PRSS1
2 pancreas, annular 31.2 SPINK1 PRSS1
3 peptic ulcer disease 30.5 SCT ATP4A ATP12A
4 eosinophilic gastroenteritis 30.4 ATP12A ALB
5 superior mesenteric artery syndrome 30.4 CRP ATP4A ATP12A
6 blind loop syndrome 30.3 ATP4A ATP12A ALB
7 volvulus of midgut 30.3 CRP ATP4A ATP12A ALB
8 pneumatosis cystoides intestinalis 30.2 ATP4A ATP12A
9 intestinal obstruction 30.2 CRP CEACAM5 ATP4A ATP12A ALB
10 chronic duodenal ileus 30.2 CRP ALB
11 cholangitis 30.0 CRP CEACAM5 ALB
12 peptic esophagitis 30.0 ATP4A ATP12A ALB
13 pancreatitis 29.9 SPINK1 SCT PRSS1 CRP
14 duodenogastric reflux 29.8 SCT ATP4A ATP12A
15 bile duct cysts 29.8 SPINK1 PRSS1 CEACAM5 ALB
16 duodenum cancer 29.8 SCT CEACAM5
17 bile reflux 29.8 SCT ATP4A ATP12A ALB
18 intussusception 29.7 CRP ALB
19 pancreatic agenesis 1 29.7 SPINK1 SCT
20 acute pancreatitis 29.7 SPINK1 SCT PRSS1 CRP
21 aspiration pneumonia 29.7 CRP ATP4A ATP12A ALB
22 chronic pyelonephritis 29.6 CRP ALB
23 compartment syndrome 29.6 CRP ALB
24 biliary tract disease 29.6 CRP CEACAM5 ALB
25 median arcuate ligament syndrome 29.6 CRP ATP4A ATP12A
26 active peptic ulcer disease 29.5 CRP ATP4A ATP12A ALB
27 meckel diverticulum 29.5 CRP ATP4A ALB
28 constipation 29.5 CRP ATP4A ATP12A ALB
29 alcoholic pancreatitis 29.5 SPINK1 SCT PRSS1
30 acute cholangitis 29.5 CRP CEACAM5 ALB
31 gallbladder disease 29.4 CRP CEACAM5 ALB
32 chronic intestinal vascular insufficiency 29.3 CRP ATP4A ATP12A ALB
33 paralytic ileus 29.3 CRP ATP4A ATP12A ALB
34 duodenitis 29.3 CRP ATP4A ATP12A ALB
35 exanthem 29.3 CRP ATP4A ATP12A ALB
36 cholangitis, primary sclerosing 29.3 SCT CRP ALB
37 gastric dilatation 29.2 TUSC1 ST7 CRP ATP4A ATP12A
38 lacrimoauriculodentodigital syndrome 11.2
39 duodenal atresia 10.6
40 aortic aneurysm 10.5
41 aortic aneurysm, familial abdominal, 1 10.5
42 ileus 10.4
43 down syndrome 10.4
44 aneurysm 10.4
45 pancreatic cancer 10.4
46 vagus nerve disease 10.4 ATP4A ATP12A
47 scalp dermatosis 10.4 ATP4A ATP12A
48 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
49 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
50 lingual goiter 10.4 ATP4A ATP12A

Graphical network of the top 20 diseases related to Duodenal Obstruction:



Diseases related to Duodenal Obstruction

Symptoms & Phenotypes for Duodenal Obstruction

Drugs & Therapeutics for Duodenal Obstruction

Drugs for Duodenal Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
2
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4 Neurotransmitter Agents Phase 3
5 Analgesics, Non-Narcotic Phase 3
6 Fibrinolytic Agents Phase 3
7 Gastrointestinal Agents Phase 3
8 Antirheumatic Agents Phase 3
9 Purinergic P2Y Receptor Antagonists Phase 3
10 Cyclooxygenase Inhibitors Phase 3
11 Anti-Inflammatory Agents Phase 3
12 Analgesics Phase 3
13 Antacids Phase 3
14 Platelet Aggregation Inhibitors Phase 3
15 Antipyretics Phase 3
16 Proton Pump Inhibitors Phase 3
17 Anti-Ulcer Agents Phase 3
18 Anti-Inflammatory Agents, Non-Steroidal Phase 3
19 Cola Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
2 A Pilot Phase I/II Trial of Enteral Wallstents for Duodenal Obstruction in the Setting of Malignancy Completed NCT00004910 Phase 1, Phase 2
3 Gastroenteric Anastomosis With Natural Orifice Translumenal Endoscopic Surgery (NOTES) Using the New Fashionned Tissue Apposing Stent Axios® for the Treatment of Antro-pyloric or Duodenal Obstructions : Prospective Evaluation of Feasibility, Efficacy and Tolerance. Unknown status NCT02562157
4 Comparison of Duodenal Stenting vs Transpyloric and Duodenal Stenting for Malignant Obstruction Completed NCT03125148
5 Treatment of Duodenal or Gastric Outlet Obstruction and Duodenal Strictures Caused by Malignant Neoplasms With the EVOLUTION® Duodenal Stent Completed NCT00991614
6 Validation of a Totally Synthetic High Fidelity Laparoscopic Duodenal Atresia (DA) Surgical Simulator Recruiting NCT04114279

Search NIH Clinical Center for Duodenal Obstruction

Cochrane evidence based reviews: duodenal obstruction

Genetic Tests for Duodenal Obstruction

Anatomical Context for Duodenal Obstruction

MalaCards organs/tissues related to Duodenal Obstruction:

40
Pancreas, Colon, Small Intestine, Spleen, Thyroid, Appendix

Publications for Duodenal Obstruction

Articles related to Duodenal Obstruction:

(show top 50) (show all 1599)
# Title Authors PMID Year
1
Large Pancreatic Lipoma Causing Duodenal Obstruction. 61
32779086 2021
2
[Value of chromosomal microarray analysis for fetuses with duodenal obstruction]. 61
33751526 2021
3
Successful EUS-guided gastrojejunostomy with very long-term patency for duodenal obstruction after severe acute pancreatitis. 61
33711188 2021
4
Outcomes and survival of infants with congenital duodenal obstruction following Kimura procedure with post-anastomosis jejunostomy feeding tube. 61
33663393 2021
5
Endoscopic Ultrasound-Guided Hepaticogastrostomy: Technical Review and Tips to Prevent Adverse Events. 61
32694240 2021
6
Contemporary management of pancreas cancer in older people. 61
32950314 2021
7
One-year Outcomes of Congenital Duodenal Obstruction: A Population-based Study. 61
32826802 2021
8
Endoscopic cystogastrostomy: Still a viable option in children with symptomatic pancreatic fluid collection. 61
33602644 2021
9
Superior mesenteric artery syndrome in a patient with celiacomesenteric trunk. 61
33622741 2021
10
Duodenal Obstruction after Endovascular Repair of a Ruptured Abdominal Aorta Aneurysm. 61
33556527 2021
11
Bouveret syndrome: a rare form of gallstone ileus. 61
33526527 2021
12
Microarray analysis in fetuses with duodenal obstruction: It is not just trisomy 21. 61
33000500 2021
13
The coronal aorto-mesenteric orientation theory for post-operative nausea and vomiting following scoliosis surgery in children: a pilot study. 61
33244810 2021
14
Spontaneously resolving duodenal obstruction after balloon-occluded retrograde transvenous obliteration-assisted endoscopic Histoacryl injection in duodenal varices. 61
32721492 2021
15
The incidence of abdominal surgical site infections after abdominal birth defects surgery in infants: A systematic review with meta-analysis. 61
33485614 2021
16
Comparison Study between Double Bare Covered and Fully Covered Metal Stent during Endoscopic Ultrasound-Guided Choledochoduodenostomy (with Video). 61
32731245 2021
17
EUS-guided gastroenterostomy for duodenal obstruction secondary to superior mesenteric artery syndrome. 61
33490746 2021
18
Endoscopic ultrasound-guided gastroenterostomy with water-jet filling technique through a 19G needle to treat complete malignant duodenal obstruction. 61
32428950 2021
19
Clinical significance of prenatal double bubble sign on perinatal outcome and literature review. 61
33455511 2021
20
A contemporary analysis of palliative procedures in aborted pancreatoduodenectomy: Morbidity, mortality, and impact on future therapy. 61
32888713 2020
21
Delayed presentation of a congenital duodenal web managed successfully with incision of web. 61
33370983 2020
22
Food-Induced Duodenal Obstruction Successfully Reopened by Endoscopic Treatment. 61
33489587 2020
23
Duodenal Obstruction Caused by the Long-term Recurrence of Appendiceal Goblet Cell Carcinoid. 61
32759580 2020
24
Cholescintigraphy for Differentiation of True Duodenal Obstruction from Pseudo Obstruction. 61
32709672 2020
25
Abdominal aortic aneurysm and its association with duodenal obstruction: aortoduodenal syndrome. 61
33299591 2020
26
Retroperitoneal Metastasis, with Marked Fibrosis, of Lung Adenocarcinoma after Afatinib Treatment: An Autopsy Case Report. 61
32727983 2020
27
EUS-guided choledocoduodenostomy and gastroenterostomy to palliate simultaneous biliary and duodenal obstruction due to pancreatic cancer. 61
33140024 2020
28
Superior mesenteric artery syndrome. 61
33235782 2020
29
Combination of endoscopic-ultrasound guided choledochoduodenostomy and gastrojejunostomy resolving combined distal biliary and duodenal obstruction. 61
33212523 2020
30
Double stenting with EUS-CDS using a new anti-reflux metal stent for combined malignant biliary and duodenal obstruction. 61
32846046 2020
31
Enhanced recovery after surgery for the treatment of congenital duodenal obstruction. 61
32571537 2020
32
Groove pancreatitis: a rare cause of severe gastric dilation. 61
33054295 2020
33
Idiopathic retroperitoneal haematoma causing duodenal obstruction: a case report and review of literature. 61
32538127 2020
34
Complete laparoscopic duodenojejunostomy for superior mesenteric artery syndrome: Linear stapled closure of the common enterotomy. 61
31845494 2020
35
Bouveret Syndrome: A Systematic Review of Endoscopic Therapy and a Novel Predictive Tool to Aid in Management. 61
32898384 2020
36
Spontaneous resolution of idiopathic intestinal obstruction after pneumonia: A case report. 61
33083412 2020
37
Appearance of fetal intestinal obstruction on fetal MRI. 61
32594545 2020
38
The value of saline-aided ultrasound in diagnosing congenital duodenal obstruction. 61
32715324 2020
39
Chylous Ascites: A Rare Initial Presentation of Pancreatic Carcinoma. 61
33036689 2020
40
Endoscopic ultrasound-guided hepaticogastrostomy combined with gastroenterostomy in a case of complete duodenal obstruction. 61
32877941 2020
41
Wilkie's Syndrome as a Rare Cause of Duodenal Obstruction: Perspicacity Is in the Radiological Details. 61
33083170 2020
42
Single-session bridge-to-surgery choledochoduodenostomy and duodenal stenting in patient with malignant biliary and duodenal obstruction. 61
32106315 2020
43
Superior Mesenteric Artery Syndrome: A Forgotten Cause of Duodenal Obstruction. 61
33133874 2020
44
Outcomes of over-the-scope clip application in various gastrointestinal indications: experience from a tertiary care in India. 61
32879593 2020
45
[Indications for Surgical Therapy in Chronic Pancreatitis]. 61
32726816 2020
46
Duodenal obstruction due to accidental swallowing of a dental prosthesis: a case report and review of the literature. 61
32799932 2020
47
Incomplete congenital duodenal obstruction: a diagnostic challenge. 61
30692125 2020
48
Blind Spot of Enteral Stenting for Malignant Duodenal Obstruction due to Colon Cancer: A Rare Case of Duodenocolonic Fistula. 61
33296958 2020
49
Duplication cyst with midgut volvulus in a neonate: an unusual presentation. 61
32847882 2020
50
The application of prenatal ultrasound in the diagnosis of congenital duodenal obstruction. 61
32620086 2020

Variations for Duodenal Obstruction

Expression for Duodenal Obstruction

Search GEO for disease gene expression data for Duodenal Obstruction.

Pathways for Duodenal Obstruction

GO Terms for Duodenal Obstruction

Cellular components related to Duodenal Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 SPINK1 SCT PRSS3P2 PRSS1 CRP ATP4A

Biological processes related to Duodenal Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
2 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
3 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Duodenal Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Duodenal Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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