MCID: DDN005
MIFTS: 33

Duodenal Somatostatinoma

Categories: Cancer diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Duodenal Somatostatinoma

MalaCards integrated aliases for Duodenal Somatostatinoma:

Name: Duodenal Somatostatinoma 12 15
Duodenal Somatostatin-Producing Neuroendocrine Tumor 74
Duodenal Delta Cell Somatostatin Producing Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7479
NCIt 51 C27407
UMLS 74 C1333320

Summaries for Duodenal Somatostatinoma

MalaCards based summary : Duodenal Somatostatinoma, also known as duodenal somatostatin-producing neuroendocrine tumor, is related to somatostatinoma and paraganglioma, and has symptoms including diarrhea An important gene associated with Duodenal Somatostatinoma is SST (Somatostatin), and among its related pathways/superpathways are Neuroscience and MECP2 and Associated Rett Syndrome. Affiliated tissues include pituitary, thyroid and lung, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Duodenal Somatostatinoma

Diseases related to Duodenal Somatostatinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 somatostatinoma 30.3 CALCA ENO2 INS SST
2 paraganglioma 29.8 ENO2 NF1 SST
3 gastrinoma 10.3 INS SST
4 postgastrectomy syndrome 10.3 INS SST
5 pancreatic endocrine carcinoma 10.3 INS SST
6 insulinomatosis and diabetes mellitus 10.3 INS SST
7 insulinoma 10.3 INS SST
8 hyperpituitarism 10.3 INS SST
9 dumping syndrome 10.3 INS SST
10 functional gastric disease 10.2 INS SST
11 pancreatic cystadenoma 10.2 INS SST
12 neurofibromatosis, type i 10.2
13 neurofibromatosis, type iv, of riccardi 10.2
14 endocrine pancreas disease 10.2 INS SST
15 pituitary-dependent cushing's disease 10.2 INS SST
16 malignant glandular tumor of peripheral nerve sheath 10.2 NF1 SST
17 multiple endocrine neoplasia, type i 10.2 INS SST
18 retinitis pigmentosa 40 10.2 PPY SST
19 pituitary gland disease 10.2 INS SST
20 hyperinsulinemic hypoglycemia 10.2 INS SST
21 duodenal ulcer 10.2 INS SST
22 fetal erythroblastosis 10.2 INS PPY
23 cell type benign neoplasm 10.2 INS SST
24 mongolian spot 10.2 ENO2 SST
25 retroperitoneal neuroblastoma 10.2 ENO2 SST
26 carcinoid tumors, intestinal 10.1 ENO2 SST
27 duodenum cancer 10.1 ENO2 SST
28 glucose metabolism disease 10.1 INS SST
29 mixed ductal-endocrine carcinoma 10.1 ENO2 SST
30 ileum cancer 10.1 ENO2 SST
31 granulosa cell tumor of the ovary 10.1 ENO2 INS
32 epithelioid malignant peripheral nerve sheath tumor 10.1 ENO2 NF1
33 acquired metabolic disease 10.1 INS SST
34 plexiform schwannoma 10.1 ENO2 NF1
35 autonomic nervous system benign neoplasm 10.1 ENO2 NF1
36 spinal meningioma 10.0 ENO2 NF1
37 wdha syndrome 10.0 CALCA SST
38 spinal canal and spinal cord meningioma 10.0 ENO2 NF1
39 acromegaly 10.0 INS SST
40 optic nerve neoplasm 10.0 ENO2 NF1
41 prolactin producing pituitary tumor 10.0 CALCA SST
42 juvenile pilocytic astrocytoma 10.0 ENO2 NF1
43 pineal parenchymal tumor of intermediate differentiation 10.0 ENO2 NF1
44 autosomal genetic disease 10.0 INS NF1
45 merkel cell carcinoma 10.0 ENO2 SST
46 optic nerve glioma 10.0 ENO2 NF1
47 status epilepticus 10.0 ENO2 SST
48 hyperthyroidism 10.0 INS SST
49 plethora of newborn 10.0 CALCA INS
50 von hippel-lindau syndrome 10.0

Graphical network of the top 20 diseases related to Duodenal Somatostatinoma:



Diseases related to Duodenal Somatostatinoma

Symptoms & Phenotypes for Duodenal Somatostatinoma

UMLS symptoms related to Duodenal Somatostatinoma:


diarrhea

MGI Mouse Phenotypes related to Duodenal Somatostatinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 ENO2 INS NF1 PPY SLC25A13 SST
2 growth/size/body region MP:0005378 9.1 ENO2 INS NF1 PPY SLC25A13 SST

Drugs & Therapeutics for Duodenal Somatostatinoma

Search Clinical Trials , NIH Clinical Center for Duodenal Somatostatinoma

Genetic Tests for Duodenal Somatostatinoma

Anatomical Context for Duodenal Somatostatinoma

MalaCards organs/tissues related to Duodenal Somatostatinoma:

42
Pituitary, Thyroid, Lung, Pancreas, Testes, Ovary, Spinal Cord

Publications for Duodenal Somatostatinoma

Articles related to Duodenal Somatostatinoma:

(show all 31)
# Title Authors Year
1
Duodenal somatostatinoma presenting as obstructive jaundice with the coexistence of a gastrointestinal stromal tumour in neurofibromatosis type 1: a case with review of the literature. ( 30635305 )
2019
2
Education and imaging. Gastrointestinal: neurofibromatosis type 1, duodenal somatostatinoma and gastrointestinal stromal tumors; a triad worth remembering. ( 24646427 )
2014
3
Duodenal somatostatinoma: a case report and review of the literature. ( 23618063 )
2013
4
Endoscopic submucosal dissection of solitary duodenal somatostatinoma (with video). ( 22018555 )
2012
5
Duodenal somatostatinoma: a case report and review. ( 21437171 )
2011
6
Duodenal somatostatinoma and gastrointestinal stromal tumor associated with neurofibromatosis type 1: diagnosis with PET/CT. ( 16861519 )
2006
7
Duodenal somatostatinoma: clinical and immunohistochemical patterns--difficult differential diagnosis in regard to gangliocytic paraganglioma: report of a case. ( 15851380 )
2005
8
Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion. ( 16105971 )
2005
9
Von Recklinghausen's neurofibromatosis associated with duodenal somatostatinoma. A case report and review of the literature. ( 15258554 )
2004
10
Large duodenal somatostatinoma in the third portion associated with severe glucose intolerance. ( 15468970 )
2004
11
Duodenal somatostatinoma associated with Von Recklinghausen's disease. ( 15619018 )
2004
12
Duodenal somatostatinoma: a rare cause of gastrointestinal bleeding. ( 12897887 )
2003
13
Malignant duodenal somatostatinoma presenting in association with von Recklinghausen disease. ( 14700294 )
2003
14
Duodenal somatostatinoma and erythrocytosis in a patient with von Hippel-Lindau disease type 2A. ( 11201368 )
2001
15
Duodenal somatostatinoma of the ampulla of vater diagnosed by endoscopic fine needle aspiration biopsy: a case report. ( 11480730 )
2001
16
Duodenal somatostatinoma presenting with complete somatostatinoma syndrome. ( 11606861 )
2001
17
Duodenal somatostatinoma: a case report and review of 31 cases with special reference to the relationship between tumor size and metastasis. ( 10792774 )
2000
18
Longevity possible in metastatic duodenal somatostatinoma. ( 11107073 )
2000
19
Duodenal somatostatinoma presenting as upper gastrointestinal bleeding. ( 10235228 )
1999
20
Thirty-Year Survival with an Untreated Malignant Duodenal Somatostatinoma. ( 12114786 )
1998
21
Small duodenal somatostatinoma with high plasma somatostatin level. ( 9177540 )
1997
22
[Pancreatic and duodenal somatostatinoma. Two clinico-pathologic entities]. ( 9172623 )
1996
23
Von Recklinghausen's disease associated with duodenal somatostatinoma: contrast of duodenal versus pancreatic somatostatinomas. ( 7745981 )
1995
24
Exocrine pancreatic insufficiency and pancreatic fibrosis due to duodenal somatostatinoma in a patient with neurofibromatosis. ( 1348357 )
1992
25
Duodenal somatostatinoma with congenital pseudoarthrosis. ( 2033227 )
1991
26
Duodenal somatostatinoma with psammoma bodies. ( 2565711 )
1989
27
A polypoid duodenal somatostatinoma. A case report. ( 2830659 )
1988
28
Duodenal somatostatinoma with psammoma bodies: an immunohistochemical and ultrastructural study. ( 2867674 )
1986
29
Duodenal somatostatinoma. ( 6318875 )
1984
30
A case of duodenal somatostatinoma: diagnostic usefulness of calcium--pentagastrin test. ( 6137434 )
1983
31
Duodenal somatostatinoma. Immunohistopathology and review of literature. ( 6301208 )
1983

Variations for Duodenal Somatostatinoma

Expression for Duodenal Somatostatinoma

Search GEO for disease gene expression data for Duodenal Somatostatinoma.

Pathways for Duodenal Somatostatinoma

Pathways related to Duodenal Somatostatinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 CALCA ENO2 NF1
2 11.05 NF1 SST
3 10.9 INS NF1
4 10.27 INS NF1

GO Terms for Duodenal Somatostatinoma

Cellular components related to Duodenal Somatostatinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CALCA ENO2 INS PPY SST
2 neuronal cell body GO:0043025 8.96 ENO2 SST

Biological processes related to Duodenal Somatostatinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.73 CALCA INS PPY SST
2 cell-cell signaling GO:0007267 9.43 CALCA INS SST
3 cognition GO:0050890 9.37 INS NF1
4 gluconeogenesis GO:0006094 9.32 ENO2 SLC25A13
5 negative regulation of osteoclast differentiation GO:0045671 9.16 CALCA NF1
6 response to heat GO:0009408 9.1 SST
7 positive regulation of blood vessel diameter GO:0097755 8.96 CALCA INS
8 regulation of signaling receptor activity GO:0010469 8.92 CALCA INS PPY SST

Molecular functions related to Duodenal Somatostatinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CALCA INS PPY SST

Sources for Duodenal Somatostatinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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