MCID: DDN005
MIFTS: 33

Duodenal Somatostatinoma

Categories: Cancer diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Duodenal Somatostatinoma

MalaCards integrated aliases for Duodenal Somatostatinoma:

Name: Duodenal Somatostatinoma 12 15
Duodenal Somatostatin-Producing Neuroendocrine Tumor 73
Duodenal Delta Cell Somatostatin Producing Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7479
NCIt 50 C27407
UMLS 73 C1333320

Summaries for Duodenal Somatostatinoma

MalaCards based summary : Duodenal Somatostatinoma, also known as duodenal somatostatin-producing neuroendocrine tumor, is related to somatostatinoma and paraganglioma, and has symptoms including diarrhea An important gene associated with Duodenal Somatostatinoma is SST (Somatostatin), and among its related pathways/superpathways are Neuroscience and MECP2 and Associated Rett Syndrome. Affiliated tissues include lung, ovary and spinal cord, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Duodenal Somatostatinoma

Diseases related to Duodenal Somatostatinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 somatostatinoma 30.7 CALCA ENO2 INS SST
2 paraganglioma 29.7 ENO2 NF1 SST
3 gastrinoma 10.2 INS SST
4 postgastrectomy syndrome 10.2 INS SST
5 postural hypotension 10.2 INS SST
6 pancreatic endocrine carcinoma 10.2 INS SST
7 insulinomatosis and diabetes mellitus 10.2 INS SST
8 insulinoma 10.2 INS SST
9 hyperpituitarism 10.2 INS SST
10 dumping syndrome 10.2 INS SST
11 functional gastric disease 10.2 INS SST
12 pancreatic cystadenoma 10.2 INS SST
13 endocrine pancreas disease 10.1 INS SST
14 pituitary-dependent cushing's disease 10.1 INS SST
15 mongolian spot 10.1 ENO2 SST
16 retroperitoneal neuroblastoma 10.1 ENO2 SST
17 multiple endocrine neoplasia, type i 10.1 INS SST
18 neurofibromatosis, type i 10.1
19 carcinoid tumors, intestinal 10.1 ENO2 SST
20 retinitis pigmentosa 40 10.1 PPY SST
21 pituitary gland disease 10.1 INS SST
22 duodenum cancer 10.1 ENO2 SST
23 hyperinsulinemic hypoglycemia 10.1 INS SST
24 mixed ductal-endocrine carcinoma 10.1 ENO2 SST
25 duodenal ulcer 10.1 INS SST
26 fetal erythroblastosis 10.1 INS PPY
27 ileum cancer 10.1 ENO2 SST
28 cell type benign neoplasm 10.1 INS SST
29 wdha syndrome 10.1 CALCA SST
30 granulosa cell tumor of the ovary 10.1 ENO2 INS
31 prolactin producing pituitary tumor 10.1 CALCA SST
32 gallbladder disease 10.1 INS SST
33 glucose metabolism disease 10.1 INS SST
34 plethora of newborn 10.1 CALCA INS
35 autonomic nervous system disease 10.1 CALCA INS
36 merkel cell carcinoma 10.1 ENO2 SST
37 fibrous dysplasia 10.1 CALCA SST
38 lung oat cell carcinoma 10.0 CALCA ENO2
39 atypical follicular adenoma 10.0 CALCA ENO2
40 acquired metabolic disease 10.0 INS SST
41 status epilepticus 10.0 ENO2 SST
42 acute thyroiditis 10.0 CALCA ENO2
43 malignant glandular tumor of peripheral nerve sheath 10.0 NF1 SST
44 acromegaly 10.0 INS SST
45 diffuse pulmonary fibrosis 10.0 CALCA ENO2
46 cloacogenic carcinoma 10.0 CALCA ENO2
47 causalgia 10.0 CALCA ENO2
48 hyperthyroidism 10.0 INS SST
49 gastrointestinal system benign neoplasm 10.0 INS PPY SST
50 neuroma 10.0 CALCA ENO2

Graphical network of the top 20 diseases related to Duodenal Somatostatinoma:



Diseases related to Duodenal Somatostatinoma

Symptoms & Phenotypes for Duodenal Somatostatinoma

UMLS symptoms related to Duodenal Somatostatinoma:


diarrhea

MGI Mouse Phenotypes related to Duodenal Somatostatinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 ENO2 INS NF1 PPY SLC25A13 SST
2 growth/size/body region MP:0005378 9.1 ENO2 INS NF1 PPY SLC25A13 SST

Drugs & Therapeutics for Duodenal Somatostatinoma

Search Clinical Trials , NIH Clinical Center for Duodenal Somatostatinoma

Genetic Tests for Duodenal Somatostatinoma

Anatomical Context for Duodenal Somatostatinoma

MalaCards organs/tissues related to Duodenal Somatostatinoma:

41
Lung, Ovary, Spinal Cord, Pituitary, Pancreas, Thyroid, Pineal

Publications for Duodenal Somatostatinoma

Articles related to Duodenal Somatostatinoma:

(show all 30)
# Title Authors Year
1
Education and imaging. Gastrointestinal: neurofibromatosis type 1, duodenal somatostatinoma and gastrointestinal stromal tumors; a triad worth remembering. ( 24646427 )
2014
2
Duodenal somatostatinoma: a case report and review of the literature. ( 23618063 )
2013
3
Endoscopic submucosal dissection of solitary duodenal somatostatinoma (with video). ( 22018555 )
2012
4
Duodenal somatostatinoma: a case report and review. ( 21437171 )
2011
5
Duodenal somatostatinoma and gastrointestinal stromal tumor associated with neurofibromatosis type 1: diagnosis with PET/CT. ( 16861519 )
2006
6
Duodenal somatostatinoma: clinical and immunohistochemical patterns--difficult differential diagnosis in regard to gangliocytic paraganglioma: report of a case. ( 15851380 )
2005
7
Duodenal somatostatinoma associated with diabetic ketoacidosis presumably caused by somatostatin-28 hypersecretion. ( 16105971 )
2005
8
Duodenal somatostatinoma associated with Von Recklinghausen's disease. ( 15619018 )
2004
9
Large duodenal somatostatinoma in the third portion associated with severe glucose intolerance. ( 15468970 )
2004
10
Von Recklinghausen's neurofibromatosis associated with duodenal somatostatinoma. A case report and review of the literature. ( 15258554 )
2004
11
Malignant duodenal somatostatinoma presenting in association with von Recklinghausen disease. ( 14700294 )
2003
12
Duodenal somatostatinoma: a rare cause of gastrointestinal bleeding. ( 12897887 )
2003
13
Duodenal somatostatinoma of the ampulla of vater diagnosed by endoscopic fine needle aspiration biopsy: a case report. ( 11480730 )
2001
14
Duodenal somatostatinoma and erythrocytosis in a patient with von Hippel-Lindau disease type 2A. ( 11201368 )
2001
15
Duodenal somatostatinoma presenting with complete somatostatinoma syndrome. ( 11606861 )
2001
16
Longevity possible in metastatic duodenal somatostatinoma. ( 11107073 )
2000
17
Duodenal somatostatinoma: a case report and review of 31 cases with special reference to the relationship between tumor size and metastasis. ( 10792774 )
2000
18
Duodenal somatostatinoma presenting as upper gastrointestinal bleeding. ( 10235228 )
1999
19
Thirty-Year Survival with an Untreated Malignant Duodenal Somatostatinoma. ( 12114786 )
1998
20
Small duodenal somatostatinoma with high plasma somatostatin level. ( 9177540 )
1997
21
[Pancreatic and duodenal somatostatinoma. Two clinico-pathologic entities]. ( 9172623 )
1996
22
Von Recklinghausen's disease associated with duodenal somatostatinoma: contrast of duodenal versus pancreatic somatostatinomas. ( 7745981 )
1995
23
Exocrine pancreatic insufficiency and pancreatic fibrosis due to duodenal somatostatinoma in a patient with neurofibromatosis. ( 1348357 )
1992
24
Duodenal somatostatinoma with congenital pseudoarthrosis. ( 2033227 )
1991
25
Duodenal somatostatinoma with psammoma bodies. ( 2565711 )
1989
26
A polypoid duodenal somatostatinoma. A case report. ( 2830659 )
1988
27
Duodenal somatostatinoma with psammoma bodies: an immunohistochemical and ultrastructural study. ( 2867674 )
1986
28
Duodenal somatostatinoma. ( 6318875 )
1984
29
Duodenal somatostatinoma. Immunohistopathology and review of literature. ( 6301208 )
1983
30
A case of duodenal somatostatinoma: diagnostic usefulness of calcium--pentagastrin test. ( 6137434 )
1983

Variations for Duodenal Somatostatinoma

Expression for Duodenal Somatostatinoma

Search GEO for disease gene expression data for Duodenal Somatostatinoma.

Pathways for Duodenal Somatostatinoma

Pathways related to Duodenal Somatostatinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 CALCA ENO2 NF1
2 11.05 NF1 SST
3 10.9 INS NF1
4 10.27 INS NF1

GO Terms for Duodenal Somatostatinoma

Cellular components related to Duodenal Somatostatinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.13 CALCA ENO2 SST
2 extracellular space GO:0005615 9.02 CALCA ENO2 INS PPY SST

Biological processes related to Duodenal Somatostatinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.73 CALCA INS PPY SST
2 cell-cell signaling GO:0007267 9.43 CALCA INS SST
3 response to heat GO:0009408 9.4 CALCA SST
4 cognition GO:0050890 9.37 INS NF1
5 gluconeogenesis GO:0006094 9.32 ENO2 SLC25A13
6 negative regulation of osteoclast differentiation GO:0045671 9.16 CALCA NF1
7 positive regulation of blood vessel diameter GO:0097755 8.96 CALCA INS
8 regulation of signaling receptor activity GO:0010469 8.92 CALCA INS PPY SST

Molecular functions related to Duodenal Somatostatinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CALCA INS PPY SST

Sources for Duodenal Somatostatinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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