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MCID: DDN001
MIFTS: 53

Duodenal Ulcer

Categories: Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Duodenal Ulcer

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MalaCards integrated aliases for Duodenal Ulcer:

Name: Duodenal Ulcer 12 55 44 15 73
Stress Ulcer 12 55 73
Curling Ulcer 12 73
Stress Ulcer of Stomach 73
Duodenal Ulcer Disease 55
Curling's Ulcers 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1724
ICD10 33 K26
ICD9CM 35 532
MeSH 44 D004381
NCIt 50 C26755
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Summaries for Duodenal Ulcer

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MalaCards based summary : Duodenal Ulcer, also known as stress ulcer, is related to peptic ulcer disease and duodenitis. An important gene associated with Duodenal Ulcer is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Allograft rejection and Immune response IFN alpha/beta signaling pathway. The drugs Rabeprazole and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and testes.

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Related Diseases for Duodenal Ulcer

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Diseases in the Duodenal Ulcer family:

Duodenal Ulcer Due to Antral G-Cell Hyperfunction

Diseases related to Duodenal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 325)
# Related Disease Score Top Affiliating Genes
1 peptic ulcer disease 31.3 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
2 duodenitis 30.8 GAST INS
3 helicobacter pylori infection 30.7 CXCL8 CYP2C19 GAST IL1B S100A8
4 pancreatitis 30.5 CCK SCT SST
5 gastritis 30.5 CXCL8 GAST HRH2 IL1B IL1RN S100A8
6 esophagitis 30.5 CXCL8 CYP2C19 HRH2 IL1B
7 peptic esophagitis 30.4 CXCL8 CYP2C19 HRH2 IL1B
8 zollinger-ellison syndrome 30.3 GAST HRH2 SCT SST
9 gastroenteritis 30.3 CXCL8 IL1B TNF
10 dyspepsia 30.2 CCK CXCL8 CYP2C19 HRH2 SST
11 gastric ulcer 30.1 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
12 peritonitis 30.1 CXCL8 IL1B TNF
13 duodenogastric reflux 30.0 CCK GAST SCT SST
14 appendicitis 30.0 CXCL8 IL1B TNF
15 pancreatic cancer 29.8 CCK GAST GRP SCT SST
16 meningitis 29.8 CXCL8 IL1B TNF
17 acute pancreatitis 29.8 CCK CXCL8 SCT SST
18 haemophilus influenzae 29.8 CXCL8 IL1B TNF
19 colitis 29.8 CXCL8 IL1B TNF
20 atrophic gastritis 29.8 CXCL8 GAST IL1B IL1RN S100A8 SST
21 dumping syndrome 29.8 INS SCT SST
22 lymphadenitis 29.8 CXCL8 IL1B TNF
23 gastroesophageal reflux 29.8 CCK CXCL8 CYP2C19 GAST HRH2 IL1B
24 intestinal disease 29.8 CXCL8 IL1B TNF
25 pneumonia 29.7 CXCL8 IL1B TNF
26 viral infectious disease 29.7 CXCL8 IL1B TNF
27 diarrhea 29.7 CCK GAST SST
28 ulcerative colitis 29.7 CXCL8 IL1B TNF
29 insulinoma 29.7 INS SCT SST
30 gastrinoma 29.6 GAST INS SCT SST
31 steatorrhea 29.6 CCK SCT SST
32 periodontal disease 29.6 CXCL8 IL1B IL1RN TNF
33 neuroendocrine tumor 29.6 CCK GAST GRP SST
34 islet cell tumor 29.6 GAST INS SST
35 burns 29.5 IL1B INS TNF
36 duodenal gastrinoma 29.3 CCK GAST GRP SCT SST
37 behcet syndrome 29.3 CXCL8 IL1B IL1RN LTA TNF
38 arthritis 29.3 CXCL8 IL1B IL1RN LTA TNF
39 multiple endocrine neoplasia, type i 29.3 GAST INS SCT SST
40 diabetes mellitus 28.9 IL1B IL1RN INS LTA SST TNF
41 pancreas disease 28.9 CCK GAST INS SCT SST TNF
42 myocardial infarction 28.7 CYP2C19 IL1B INS LTA TNF
43 gastrointestinal system disease 28.6 CCK CXCL8 GAST IL1B INS S100A8
44 tremor, nystagmus, and duodenal ulcer 12.3
45 duodenal ulcer due to antral g-cell hyperfunction 12.3
46 duodenal ulcer, hyperpepsinogenemic i 12.2
47 chronic erosive gastritis 11.3
48 neuhauser daly magnelli syndrome 11.2
49 xanthinuria, type ii 11.2
50 gastric cancer 10.5

Graphical network of the top 20 diseases related to Duodenal Ulcer:



Diseases related to Duodenal Ulcer
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Symptoms & Phenotypes for Duodenal Ulcer

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Drugs & Therapeutics for Duodenal Ulcer

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Drugs for Duodenal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 117976-89-3 5029
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 26787-78-0 33613
3
Clarithromycin Approved Phase 4,Phase 2,Phase 3 81103-11-9 84029
4
Metronidazole Approved Phase 4,Phase 2,Phase 3 443-48-1 4173
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
6
Pantoprazole Approved Phase 4,Phase 3,Phase 1,Not Applicable 102625-70-7 4679
7
Dexlansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3, 138530-94-6 9578005
8
Lansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3 3883
9
Acetaminophen Approved Phase 4 103-90-2 1983
10
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
11
Potassium Citrate Approved, Investigational, Vet_approved Phase 4,Phase 3
12
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
13
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 22204-53-1 1302 156391
14
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
15
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
16
Ranitidine Approved Phase 4,Phase 3 66357-35-5, 66357-59-3 3001055
17
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
18
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
19
Loxoprofen Investigational Phase 4 80382-23-6, 68767-14-6 3965
20
Furazolidone Experimental, Vet_approved Phase 4 67-45-8 5323714 3435
21 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
22 Antiprotozoal Agents Phase 4,Phase 2,Phase 3
23 Antacids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
25 Antiparasitic Agents Phase 4,Phase 2,Phase 3
26 Proton Pump Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Anti-Ulcer Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3
29 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
30 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Antipyretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Antibiotics, Antitubercular Phase 4
42 Natriuretic Agents Phase 4,Phase 3,Phase 2
43
Bismuth Phase 4,Phase 3 7440-69-9 16682734 105143
44 Citrate Phase 4,Phase 3
45 Respiratory System Agents Phase 4,Phase 3
46 Expectorants Phase 4,Phase 3
47 diuretics Phase 4,Phase 3,Phase 2
48 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3
49 Chelating Agents Phase 4,Phase 2
50 Anti-Infective Agents, Urinary Phase 4

Interventional clinical trials:

(show top 50) (show all 122)
# Name Status NCT ID Phase Drugs
1 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
2 The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers Completed NCT00594867 Phase 4 Acetaminophen - 4 grams per day + Placebo;Aspirin - 325 mg per day + Placebo;Acetaminophen 4 gram per day + Aspirin 325 mg per day
3 Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection Completed NCT00854451 Phase 4 omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin
4 Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot Completed NCT02536989 Phase 4 omeprazole;omeprazole
5 Efficacy and Safety of Ilaprazole Based Bismuth-containing Quadruple Regimen for the First-line Treatment of Helicobacter Pylori Infection Completed NCT02835560 Phase 4 Ilaprazole antisecretory drug of each quadruple therapy the Ilaprazole -based quadruple therapy;Esoprazole antisecretory drug of each quadruple therapy Esoprazole-based quadruple therapy
6 A Study of Rabeprazole and Pantoprazole on Stomach Acid and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease (GERD) and a History of Nighttime Heartburn Completed NCT00237367 Phase 4 rabeprazole and pantoprazole
7 Dual Therapy With High Doses of Ilaprazole and Amoxicillin for Helicobacter Pylori Infection Completed NCT02401477 Phase 4 Ilaprazole + Amoxicillin
8 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
9 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
10 Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen Completed NCT00346216 Phase 4 celecoxib;Ibuprofen;Naproxen
11 Study Of Celecoxib In Healthy Subjects Completed NCT00994461 Phase 4 Celecoxib;Loxoprofen;Placebo
12 The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers Recruiting NCT03342456 Phase 4 Doxycycline Hyclate Enteric-Coated Capsules;Amoxicillin Capsules;Ilaprazole Enteric-Coated Tablets;Furazolidone Tablets;Potassium Citrate Tablets
13 Helicobacter Eradication Aspirin Trial Active, not recruiting NCT01506986 Phase 4 Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg;Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
14 Lansoprazole Preventing Gastroduodenal Stress Ulcerations Terminated NCT00220909 Phase 4 Lansoprazole
15 Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control Withdrawn NCT00713947 Phase 4 during one week for the active treatments;Pantoprazole;Placebo Formula 515
16 Second Line Therapy for the Cure of Helicobacter Pylori (H. Pylori) Infection Unknown status NCT00197418 Phase 2, Phase 3 rabeprazole, amoxicillin, clarithromycin, metronidazole
17 Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori Unknown status NCT00149084 Phase 3 Lansoprazole, clarithromycin, amoxicillin
18 Efficacy and Safety of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Duodenal Ulcer Completed NCT01452724 Phase 3 TAK-438;Placebo;Lansoprazole;Placebo
19 Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Low-dose Aspirin Completed NCT01452763 Phase 3 TAK-438;Placebo;TAK-438;Placebo;Lansoprazole;Placebo
20 Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID) Completed NCT01452750 Phase 3 TAK-438;Placebo;TAK-438;Placebo;Lansoprazole;Placebo
21 Long-term Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study) Completed NCT01398410 Phase 2, Phase 3 Rabeprazole;Rabeprazole
22 Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAID Completed NCT00542789 Phase 3 Esomeprazole;Placebo
23 Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study) Completed NCT01397448 Phase 2, Phase 3 E3810;E3810;Teprenone
24 Efficacy and Safety of Lansoprazole on Gastric and Duodenal Ulcers in Patients Taking Nonsteroidal Anti-Inflammatory Drugs Completed NCT00787254 Phase 3 Lansoprazole;Gefarnate
25 Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients Completed NCT02847455 Phase 2, Phase 3 5 mg ilaprazole;10 mg ilaprazole;10 mg Rabeprazole
26 Comparative Efficacy & Safety Study of D961H Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With Low-dose Aspirin Completed NCT01069939 Phase 3 Esomeprazole;Placebo
27 Ilaprazole for the Treatment of Duodenal Ulcer in Chinese Patients (Phase 3) Completed NCT00952978 Phase 3 10 mg ilaprazole;20 mg omeprazole
28 Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Low-dose Aspirin Completed NCT01456247 Phase 3 TAK-438;Placebo;TAK-438;Placebo;Lansoprazole;Placebo
29 Long-term Extension Study of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti-inflammatory Drug (NSAID) Completed NCT01456260 Phase 3 TAK-438;Placebo;TAK-438;Placebo;Lansoprazole;Placebo
30 A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Low-Dose Aspirin Therapy Completed NCT01568398 Phase 3 TAK-438
31 A Unblinded Study of TAK-438 (20 mg) for Prevention of Recurrence of Gastric or Duodenal Ulcer During Long-Term Non-Steroid Anti-Inflammatory Drug (NSAID) Therapy Completed NCT01568385 Phase 3 TAK-438
32 Long Term Study to Investigate the Efficacy & Safety of D961H (Esomeprazole) for the Prevention of NSAIDs-induced Ulcer Completed NCT00595517 Phase 3 Esomeprazole 20 mg
33 Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on Low Dose Acetylsalicylic Acid (LDA) Completed NCT00441727 Phase 3 Esomeprazole 40 mg;Esomeprazole 20 mg;Placebo
34 Cardio-cerebrovascular Disease and Aspirin Ulcer Relapse Evaluation Completed NCT01051388 Phase 3 Low-dose PPI (Rabeprazole sodium);High-dose PPI (Rabeprazole sodium);Non-PPI (Gefarnate)
35 ASTERIX: Low Dose ASA and Nexium Completed NCT00251966 Phase 3 Esomeprazole
36 Efficacy/Safety Study as H. Pylori Eradication of Triple Therapy for 7 Days Treatment Completed NCT02084420 Phase 3 Ilaprazole;Pantoprazole
37 A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases Completed NCT02153398 Phase 3 D961H sachet 10 mg;D961H capsule 10mg;D961H capsule 20 mg
38 Ulcer Prevention II Completed NCT00629928 Phase 3 Esomeprazole;Esomeprazole;Placebo
39 Safety, Tolerability and Efficacy Study With a Fixed-Dose Combination (FDC) Ketoprofen Plus Omeprazole Completed NCT00971581 Phase 3 FDC KETOPROFEN+OMEPRAZOLE
40 A Study of Rabeprazole for Prevention of Non Steroidal Anti-inflammatory Drug -Associated Gastroduodenal Injury Completed NCT01140828 Phase 3 Rabeprazole;Rabeprazole Placebo
41 Efficacy of TAK-438, Amoxicillin and Clarithromycin in the First Line Eradication of H. Pylori Completed NCT01505127 Phase 3 TAK-438;Lansoprazole;Amoxicillin;Clarithromycin
42 Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers Completed NCT00450658 Phase 3 HZT-501;Ibuprofen
43 Efficacy and Safety Study of HZT-501 in Subjects Requiring Nonsteroidal Anti-Inflammatory Drug (NSAID) Treatment Completed NCT00450216 Phase 3 Ibuprofen/famotidine;Ibuprofen
44 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PN 200 or Naproxen in Subjects Who Are at Risk for Developing NSAID-Associated Ulcers. Completed NCT00367211 Phase 3 PN 200 tablets (500 mg naproxen and 20 mg omeprazole);Naproxen 500 mg tablets (PN 200 minus omeprazole)
45 Phase III General Clinical Study of NPO-11 in Patients Undergoing Gastric Endoscopy Completed NCT00745459 Phase 3 NPO-11
46 Misoprostol for Small Bowel Ulcers and Obscure Bleeding Due to Aspirin or Nonsteroidal Antiinflammatory Drugs Completed NCT02202967 Phase 3 Misoprostol;Placebo
47 A Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00961350 Phase 3 PA32540;EC Aspirin 325
48 Study to Evaluate the Incidence of Gastric Ulcers Following Administration of Either PA32540 or Enteric Coated Aspirin 325 mg in Subjects Who Are at Risk for Developing Aspirin-Associated Ulcers Completed NCT00960869 Phase 3 PA32540;EC-Aspirin 325 mg
49 Efficacy and Safety Study of Esomeprazole 20mg qd vs Ranitidine 150mg Bid in Patients With an NSAID-induced Gastric Ulcer Completed NCT00401752 Phase 3 Esomeprazole;Ranitidine
50 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT01129011 Phase 3 PN400 (VIMOVO);Naproxen

Search NIH Clinical Center for Duodenal Ulcer

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: duodenal ulcer

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Genetic Tests for Duodenal Ulcer

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Anatomical Context for Duodenal Ulcer

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MalaCards organs/tissues related to Duodenal Ulcer:

41
Liver, Colon, Testes, Heart, Pancreas, Bone, Breast
Sources

Publications for Duodenal Ulcer

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Articles related to Duodenal Ulcer:

(show top 50) (show all 1643)
# Title Authors Year
1
Reply to the Letter by Dr. Antonio Ponzetto Regarding "The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding". ( 29791893 )
2018
2
Laparoscopic omental filling with intraoperative endoscopy for a perforated duodenal ulcer. ( 29869066 )
2018
3
A rare complication of recurrent duodenal ulcer. ( 29549042 )
2018
4
Ten-Year Experience of Managing Giant Duodenal Ulcer Perforations with Triple Tube Ostomy at Tertiary Hospital of North India. ( 29581678 )
2018
5
Comparisons Between Bacterial Communities in Mucosa in Patients With Gastric Antrum Ulcer and a Duodenal Ulcer. ( 29868487 )
2018
6
Prevalence of Helicobacter pylori and its CagA subtypes in gastric cancer and duodenal ulcer at an Austrian tertiary referral center over 25 years. ( 29813089 )
2018
7
Management of a postbulbar duodenal ulcer and stricture causing gastric outlet obstruction: A case report. ( 29692890 )
2018
8
New single capsule of bismuth, metronidazole and tetracycline given with omeprazole versus quadruple therapy consisting of bismuth, omeprazole, amoxicillin and clarithromycin for eradication of Helicobacter pylori in duodenal ulcer patients: a Chinese prospective, randomized, multicentre trial. ( 29596646 )
2018
9
Duodenal Ulcer as a Postoperative Complication in the Donor in Living-Donor Liver Transplantation. ( 29731079 )
2018
10
Unusual Presentation of Duodenal Ulcer Presenting with Duodenal Intussusception. ( 29619400 )
2018
11
Phytobezoar and duodenal ulcer as complication of Duodopa therapy in a patient affected by Parkinson's disease. ( 29960957 )
2018
12
Containing the Costs of Recurrent Gastro-Duodenal Ulcer Bleeding. ( 29791892 )
2018
13
The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding. ( 29342468 )
2018
14
Efficacy and Tolerability of Two Quadruple Regimens: Bismuth, Omeprazole, Metronidazole with Amoxicillin or Tetracycline as First-Line Treatment for Eradication of Helicobacter Pylori in Patients with Duodenal Ulcer: A Randomized Clinical Trial. ( 29889843 )
2018
15
<i>Gemella haemolysans</i> bacteremia in a patient with secondary peritonitis due to a duodenal ulcer perforation: A case report. ( 29942771 )
2018
16
Application of over-the-scope clip for massive duodenal ulcer bleeding in a 4-year-old boy weighing 7.8 kg. ( 29169193 )
2018
17
Correlations of Acute Cerebral Hemorrhage Complicated with Stress Ulcer Bleeding with Acute Physiology and Chronic Health Evaluation (APACHE) II Score, Endothelin (ET), Tumor Necrosis Factor-alpha (TNF-α), and Blood Lipids. ( 30554231 )
2018
18
Adapted ERAS Pathway vs. Standard Care in Patients with Perforated Duodenal Ulcer-a Randomized Controlled Trial. ( 28653239 )
2018
19
Feasibility of a novel laparoscopic technique with unidirectional knotless barbed sutures for the primary closure of duodenal ulcer perforation. ( 29470633 )
2018
20
Lack of Diagnosis of Pneumoperitoneum in Perforated Duodenal Ulcer After RYGB: a Short Case Series and Review of the Literature. ( 30003474 )
2018
21
Choledochoduodenal fistula due to peptic duodenal ulcer diagnosed by X-barium meal study: interest of medical treatment. ( 30050641 )
2018
22
Acquired double pylorus: An unusual complication of duodenal ulcer. ( 30131275 )
2018
23
Successful closure of a complicated duodenal ulcer perforation with an expandable esophageal stent. ( 30141274 )
2018
24
Laparoscopy for perforated duodenal ulcer: A morbidity score based on a cohort study of 384 patients. ( 30430518 )
2018
25
Laparoscopic repair of a perforated duodenal ulcer: another use of a round ligament flap. ( 30524628 )
2018
26
MALT Lymphoma, Stress Ulcer and Cholinergic Nerves from the Viewpoint of Bilateral and Unilateral Truncal Vagotomy and Substance P. ( 29766790 )
2018
27
Enteral nutrition as stress ulcer prophylaxis in critically ill patients: A randomized controlled exploratory study. ( 28865339 )
2018
28
Stress Ulcer Prophylaxis in Neurocritical Care. ( 28929324 )
2018
29
Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials. ( 29199388 )
2018
30
Correction to: Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials. ( 29230521 )
2018
31
Pharmacological interventions for stress ulcer prophylaxis in critically ill patients: a mixed treatment comparison network meta-analysis and a recursive cumulative meta-analysis. ( 29271262 )
2018
32
Effects of stress ulcer prophylaxis in adult ICU patients receiving renal replacement therapy (Sup-Icu RENal, SIREN): Study protocol for a pre-planned observational study. ( 29321041 )
2018
33
Stress ulcer prophylaxis in intensive care unit patients receiving enteral nutrition: a systematic review and meta-analysis. ( 29374489 )
2018
34
A Successful Pharmacist-Based Quality Initiative to Reduce Inappropriate Stress Ulcer Prophylaxis Use in an Academic Medical Intensive Care Unit. ( 29502481 )
2018
35
Stress ulcer prophylaxis in adult intensive care unit patients - a protocol for a systematic review. ( 29577238 )
2018
36
The effectiveness of enteral nutrition as stress ulcer prophylaxis remains uncertain. ( 29754944 )
2018
37
Comparing efficacy of enteral nutrition plus ranitidine and enteral nutrition alone as stress ulcer prophylaxis. ( 29775083 )
2018
38
Benefit of an electronic medical record-based alarm in the optimization of stress ulcer prophylaxis. ( 29895412 )
2018
39
Epinephrine Dose Has a Preventive Effect on the Occurrence of Stress Ulcer-Induced Gastrointestinal Bleeding in Critically Ill Patients. ( 29948567 )
2018
40
Re-evaluating the Utility of Stress Ulcer Prophylaxis in the Critically Ill Patient: A Clinical Scenario-Based Meta-Analysis. ( 30101529 )
2018
41
Duodenal Ulcer - IgA Vasculitis. ( 28202872 )
2017
42
A case of an intractable duodenal ulcer associated with a pancreatic arteriovenous malformation. ( 28484196 )
2017
43
A Curious Case of Intestinal Diaphragm Disease Unmasked by Perforation of a Duodenal Ulcer. ( 28523070 )
2017
44
Perforated Duodenal Ulcer. ( 28248764 )
2017
45
Successful Endoscopic Treatment of Bouveret Syndrome in a Patient with Choledochoduodenal Fistula Complicating Duodenal Ulcer. ( 28758036 )
2017
46
Emphysematous pancreatitis associated with penetrating duodenal ulcer. ( 29358874 )
2017
47
The Relationship of Mean Platelet Volume/Platelet Distribution Width and Duodenal Ulcer Perforation. ( 28442518 )
2017
48
Endoscopic View of Gastroduodenal Artery Coils at the Base of Duodenal Ulcer in Case of Recurrent Massive Upper Gastrointestinal Bleed. ( 28507835 )
2017
49
Closure of duodenal ulcer perforation using a novel endoloop device with a single-channel gastroscope after failed laparoscopic repair. ( 28068696 )
2017
50
Massive Gastrointestinal Bleeding from Neonatal Duodenal Ulcer. ( 28975747 )
2017
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Variations for Duodenal Ulcer

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Expression for Duodenal Ulcer

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Search GEO for disease gene expression data for Duodenal Ulcer.
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Pathways for Duodenal Ulcer

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Pathways related to Duodenal Ulcer according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 37
Show member pathways
 12.7 CXCL8 IL1B INS LTA TNF
2
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.12 CXCL8 IL1B LTA TNF
3
IL-17 Family Signaling Pathways 65
Show member pathways
 12.11 CXCL8 IL1B S100A8 TNF
4
Th1 Differentiation Pathway 65
Show member pathways
 11.92 IL1B LTA TNF
5
Spinal Cord Injury 1
11.88 CXCL8 IL1B TNF
6
IL-1 Family Signaling Pathways 65
Show member pathways
 11.87 CXCL8 IL1B IL1RN TNF
7
Interleukin-4 and 13 signaling 66
11.84 CXCL8 IL1B TNF
8
TNF signaling pathway 37
11.82 IL1B LTA TNF
9
Senescence and Autophagy in Cancer 1
11.79 CXCL8 IL1B INS
10
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.77 CXCL8 IL1B IL1RN SST TNF
11
AGE-RAGE signaling pathway in diabetic complications 37
11.76 CXCL8 IL1B TNF
12
Amoebiasis 37
11.73 CXCL8 IL1B TNF
13
Rheumatoid arthritis 37
11.7 CXCL8 IL1B TNF
14
Innate Lymphoid Cell Differentiation Pathways 65
11.63 IL1B LTA TNF
15
Pertussis 37
11.59 CXCL8 IL1B TNF
16
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.55 IL1B IL1RN TNF
17
NF-kappa B signaling pathway 37
11.54 CXCL8 IL1B LTA TNF
18
Lung fibrosis 1
11.49 CXCL8 IL1B TNF
19
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.47 CXCL8 IL1B TNF
20
Legionellosis 37
11.37 CXCL8 IL1B TNF
21
Malaria 37
11.23 CXCL8 IL1B TNF
22
EBV LMP1 signaling 1
11.02 CXCL8 TNF
23
Cellular roles of Anthrax toxin 1
10.98 IL1B TNF
24
Interleukin-10 signaling 66
10.95 CXCL8 IL1B IL1RN TNF
25
G-protein signaling_RhoB regulation pathway 22
10.94 CXCL8 IL1B LTA TNF
26
Overview of nanoparticle effects 1
10.91 CXCL8 TNF
27
LDL Oxidation in Atherogenesis 64
10.82 IL1B TNF
28
Secretion of Hydrochloric Acid in Parietal Cells 1
10.13 GAST HRH2
29
Gastric acid production 1
9.77 CCK GAST GRP SCT
Sources

GO Terms for Duodenal Ulcer

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Cellular components related to Duodenal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CCK CXCL8 GAST GRP IL1B IL1RN
2 extracellular space GO:0005615 9.4 CCK CXCL8 GAST GRP IL1B IL1RN
3 secretory granule lumen GO:0034774 9.33 GRP INS S100A8

Biological processes related to Duodenal Ulcer according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.96 IL1B IL1RN LTA SST
2 cytokine-mediated signaling pathway GO:0019221 9.95 CXCL8 IL1B IL1RN TNF
3 immune response GO:0006955 9.93 CXCL8 HRH2 IL1B IL1RN LTA TNF
4 inflammatory response GO:0006954 9.92 CXCL8 IL1B IL1RN S100A8 TNF
5 cell-cell signaling GO:0007267 9.91 IL1B INS LTA SST
6 cellular response to lipopolysaccharide GO:0071222 9.85 CXCL8 IL1B IL1RN TNF
7 wound healing GO:0042060 9.83 IL1B INS S100A8
8 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.82 CCK S100A8 TNF
9 positive regulation of JNK cascade GO:0046330 9.81 IL1B IL1RN TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL1B INS S100A8 TNF
11 response to glucocorticoid GO:0051384 9.79 IL1B IL1RN TNF
12 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL1RN TNF
13 G protein-coupled receptor signaling pathway GO:0007186 9.76 CCK CXCL8 GAST GRP HRH2 INS
14 positive regulation of interferon-gamma production GO:0032729 9.73 IL1B LTA TNF
15 positive regulation of JUN kinase activity GO:0043507 9.71 IL1B IL1RN TNF
16 neutrophil chemotaxis GO:0030593 9.71 CXCL8 IL1B IL1RN S100A8
17 positive regulation of neutrophil chemotaxis GO:0090023 9.68 CXCL8 IL1B
18 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 IL1B TNF
20 negative regulation of growth of symbiont in host GO:0044130 9.67 LTA TNF
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL1B TNF
22 regulation of protein secretion GO:0050708 9.66 INS TNF
23 positive regulation of peptide hormone secretion GO:0090277 9.63 GRP INS
24 positive regulation of chemokine biosynthetic process GO:0045080 9.63 IL1B TNF
25 negative regulation of glutamate secretion GO:0014050 9.62 IL1B IL1RN
26 regulation of establishment of endothelial barrier GO:1903140 9.62 IL1B TNF
27 embryonic digestive tract development GO:0048566 9.61 CXCL8 SCT TNF
28 positive regulation of neuroinflammatory response GO:0150078 9.6 IL1B TNF
29 positive regulation of fever generation GO:0031622 9.58 IL1B TNF
30 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.58 LTA TNF
31 sequestering of triglyceride GO:0030730 9.57 IL1B TNF
32 memory GO:0007613 9.56 CCK HRH2 IL1B IL1RN
33 negative regulation of lipid catabolic process GO:0050995 9.54 IL1B INS TNF
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 IL1B TNF
35 positive regulation of glial cell proliferation GO:0060252 9.5 IL1B LTA TNF
36 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.48 LTA TNF
37 regulation of signaling receptor activity GO:0010469 9.36 CCK CXCL8 GAST GRP IL1B IL1RN
38 chronic inflammatory response to antigenic stimulus GO:0002439 9.13 IL1B IL1RN TNF
39 signal transduction GO:0007165 10.2 CCK CXCL8 GAST GRP HRH2 IL1B

Molecular functions related to Duodenal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 CXCL8 IL1B IL1RN LTA TNF
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
3 hormone activity GO:0005179 9.02 CCK GAST INS SCT SST
Sources

Sources for Duodenal Ulcer

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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