MCID: DDN001
MIFTS: 50

Duodenal Ulcer

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Duodenal Ulcer

MalaCards integrated aliases for Duodenal Ulcer:

Name: Duodenal Ulcer 12 55 44 15 17 72 33
Stress Ulcer 12 55 72
Curling Ulcer 12 72
Stress Ulcer of Stomach 72
Duodenal Ulcer Disease 55
Curling's Ulcers 12
Duodenal Ulcers 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1724
ICD9CM 35 532
MeSH 44 D004381
NCIt 50 C26755
ICD10 33 K26
UMLS 72 C0010474 C0013295 C0400807 more

Summaries for Duodenal Ulcer

MalaCards based summary : Duodenal Ulcer, also known as stress ulcer, is related to duodenitis and peritonitis. An important gene associated with Duodenal Ulcer is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Allograft rejection and Immune response IFN alpha/beta signaling pathway. The drugs Ondansetron and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and colon.

Related Diseases for Duodenal Ulcer

Diseases in the Duodenal Ulcer family:

Duodenal Ulcer Due to Antral G-Cell Hyperfunction

Diseases related to Duodenal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 584)
# Related Disease Score Top Affiliating Genes
1 duodenitis 31.6 INS GAST
2 peritonitis 31.6 TNF IL1B CXCL8
3 diarrhea 31.5 SST GAST CCK
4 peptic ulcer perforation 31.2 S100A8 HRH2 GAST
5 appendicitis 31.1 TNF IL1B CXCL8
6 constipation 31.1 SST GAST CCK
7 pancreatitis 31.0 SST SCT CCK
8 dumping syndrome 31.0 SST SCT INS
9 zollinger-ellison syndrome 31.0 SST SCT HRH2 GAST
10 helicobacter pylori infection 30.9 S100A8 IL1B GAST CYP2C19 CXCL8
11 gastritis 30.9 S100A8 IL1RN IL1B HRH2 GAST CXCL8
12 esophagitis 30.9 IL1B HRH2 CYP2C19 CXCL8
13 gastroenteritis 30.8 TNF IL1B CXCL8
14 opisthorchiasis 30.8 TNF IL1B CXCL8
15 colitis 30.8 TNF IL1B CXCL8
16 peptic esophagitis 30.8 IL1B HRH2 CYP2C19 CXCL8
17 duodenogastric reflux 30.7 SST SCT GAST CCK
18 cytomegalovirus infection 30.7 TNF IL1B CXCL8
19 gastric ulcer 30.7 IL1RN IL1B HRH2 GAST CYP2C19 CXCL8
20 dyspepsia 30.7 SST HRH2 CYP2C19 CXCL8 CCK
21 pylorospasm 30.7 SST GAST
22 gastric neuroendocrine neoplasm 30.7 SST GAST
23 meningitis 30.6 TNF IL1B CXCL8
24 ulcerative colitis 30.5 TNF IL1B CXCL8
25 pustulosis of palm and sole 30.5 TNF IL1RN
26 lymphadenitis 30.4 TNF IL1B CXCL8
27 intestinal disease 30.4 TNF IL1B CXCL8
28 peptic ulcer disease 30.4 TNF SCT S100A8 IL1RN IL1B HRH2
29 toxic shock syndrome 30.4 TNF LTA IL1B CXCL8
30 postgastrectomy syndrome 30.3 SST INS
31 acute pancreatitis 30.3 SST SCT CXCL8 CCK
32 spondylitis 30.3 TNF LTA IL1RN
33 aphthous stomatitis 30.3 TNF IL1RN IL1B
34 biliary dyskinesia 30.3 SCT CCK
35 haemophilus influenzae 30.3 TNF IL1B CXCL8
36 steatorrhea 30.2 SST SCT CCK
37 sarcoidosis 1 30.2 TNF LTA IL1B
38 chagas disease 30.2 TNF IL1B CXCL8
39 islet cell tumor 30.1 SST INS GAST
40 gastrinoma 30.1 SST SCT INS GAST
41 lung disease 30.1 TNF IL1B GRP CXCL8
42 perinatal necrotizing enterocolitis 30.1 TNF IL1B CXCL8
43 typhoid fever 30.1 TNF LTA IL1B
44 pneumonia 30.0 TNF IL1B CXCL8
45 pulmonary edema 30.0 TNF IL1B CXCL8
46 insulinoma 30.0 SST SCT INS
47 atrophic gastritis 29.9 TNF SST S100A8 IL1RN IL1B GAST
48 neuroendocrine tumor 29.8 SST GRP GAST CCK
49 gastroesophageal reflux 29.8 IL1B HRH2 GAST CYP2C19 CXCL8 CCK
50 gastric adenocarcinoma 29.6 TNF S100A8 IL1RN IL1B GAST CXCL8

Graphical network of the top 20 diseases related to Duodenal Ulcer:



Diseases related to Duodenal Ulcer

Symptoms & Phenotypes for Duodenal Ulcer

Drugs & Therapeutics for Duodenal Ulcer

Drugs for Duodenal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 182)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ondansetron Approved Phase 4 99614-02-5 4595
2
Esomeprazole Approved, Investigational Phase 4 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Ofloxacin Approved Phase 4 82419-36-1 4583
5
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
6
Sucralfate Approved Phase 4 54182-58-0
7
Ethanol Approved Phase 4 64-17-5 702
8
Nitazoxanide Approved, Investigational, Vet_approved Phase 4 55981-09-4 41684
9
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
10
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
12
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
13
Azithromycin Approved Phase 4 83905-01-5 447043 55185
14
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
15
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
16
Famotidine Approved Phase 4 76824-35-6 3325
17
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
18 Ramosetron Investigational Phase 4 132036-88-5
19
Furazolidone Experimental, Vet_approved Phase 4 67-45-8 3435 5323714
20 Tranquilizing Agents Phase 4
21 Psychotropic Drugs Phase 4
22 Antipruritics Phase 4
23 Anti-Anxiety Agents Phase 4
24 Serotonin Antagonists Phase 4
25 Serotonin Agents Phase 4
26 Emetics Phase 4
27 Antipsychotic Agents Phase 4
28 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
29 Topoisomerase Inhibitors Phase 4
30 Vitamins Phase 4
31 Dermatologic Agents Phase 4
32 Disinfectants Phase 4
33 Chlorhexidine gluconate Phase 4
34 Respiratory System Agents Phase 4
35 Expectorants Phase 4
36 Monoamine Oxidase Inhibitors Phase 4
37 Anti-Infective Agents, Local Phase 4
38 Renal Agents Phase 4
39 Antimalarials Phase 4
40 Anti-Infective Agents, Urinary Phase 4
41 Calcium, Dietary Phase 4
42
Stevioside Phase 4 57817-89-7 548198
43 Stevia Phase 4
44 Central Nervous System Depressants Phase 4
45 Hormones Phase 4
46 Autonomic Agents Phase 4
47 Antiemetics Phase 4
48 Anesthetics Phase 4
49 HIV Protease Inhibitors Phase 4
50 glucocorticoids Phase 4

Interventional clinical trials:

(show top 50) (show all 178)
# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy of Concomitant Therapy for Eradication of Helicobacter Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
2 Helicobacter Pylori Eradication Rates of Concomitant Therapy and Tailored Therapy Based on 23S Ribosomal RNA Point Mutations Associated With Clarithromycin Resistance: A Multicenter Prospective Randomized Study Unknown status NCT03130452 Phase 4 Lansoprazole 30mg;Amoxicillin 1.0g Tab;Clarithromycin 500mg;Metronidazole 500 mg
3 Clinical Trial: Esomeprazole Plus Alginate vs. Esomeprazole Alone for Treatment of Nighttime Reflux Symptom and GERD-related Sleep Disturbances in Patients With Erosive GERD Unknown status NCT02277886 Phase 4 sodium alginate;esomeprazole
4 Comparative Study of Antiemetic Effect of Ramosetron With Combination of Ondansetron and Dexamethasone in Patients Undergoing Laparoscopic Cholecystectomy Unknown status NCT02803788 Phase 4 ramosetron, ondansetron, dexamethasone
5 Comparison of the Incidence of Ventilator Associated Pneumonia in Patients Intubated With the Taper Guard Endotracheal Tube Versus a Normal Endotracheal Tube Unknown status NCT01501227 Phase 4
6 Safety and Efficacy of Lansoprazole in Patients With Reflux Disease. An Open, Single Arm, Long-term Study Completed NCT01135368 Phase 4 Lansoprazole
7 A Randomized, Two-way Crossover Study of the Effects of a Single Dose of Rabeprazole or Pantoprazole on 24-hour Intragastric Acidity and Esophageal Acid Exposure in GERD Patients With a History of Nocturnal Heartburn Completed NCT00237367 Phase 4 rabeprazole and pantoprazole
8 Effect of Prevacid on Prostaglandin Levels in the Gastric Mucosa of Patients With Stress Ulcer Completed NCT00239551 Phase 4 Prevacid
9 Phase IV Study of Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial Completed NCT00708149 Phase 4 lansoprazole OD;placebo
10 Efficacy and Safety of 1-week Triple Therapy With Ilaprazole for the Eradication of Helicobacter Pylori Completed NCT02873065 Phase 4 Ilaprazole;Esoprazole
11 The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in Helicobacter Pylori Patients Completed NCT02648659 Phase 4 Ilaprazole;Amoxicillin;Clarithromycin;Metronidazole
12 Efficacy and Safety of Ilaprazole Based Bismuth-containing Quadruple Regimen for the First-line Treatment of Helicobacter Pylori Infection Completed NCT02835560 Phase 4 Ilaprazole antisecretory drug of each quadruple therapy the Ilaprazole -based quadruple therapy;Esoprazole antisecretory drug of each quadruple therapy Esoprazole-based quadruple therapy
13 Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection - A Combination of Clinical and Pharmacogenetic Study Completed NCT00854451 Phase 4 omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin
14 Effect of Intravenous Esomeprazole Versus Ranitidine on Gastric pH in Critically Ill Patients - a Prospective, Randomized, Double-Blind Study. Completed NCT00590928 Phase 4 esomeprazole;ranitidine
15 An Open-Label, Exploratory Trial to Assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium I.V. (Esomeprazole Sodium) 40mg BID for up to 72 Hours Completed NCT00428701 Phase 4 Esomeprazole Sodium
16 Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU) Completed NCT02467621 Phase 4 Pantoprazole
17 Dual Therapy With High Doses of Ilaprazole and Amoxicillin for Helicobacter Pylori Infection; Studies From Korea Completed NCT02401477 Phase 4 Ilaprazole + Amoxicillin
18 Comparison of High Dose Infusion and Low Dose Bolus Intravenous Omeprazole for Treatment of Bleeding Ulcer With Adherent Clot Completed NCT02536989 Phase 4 omeprazole;omeprazole
19 Prevention of Recurrent Idiopathic Gastroduodenal Ulcer Bleeding: a Double-blind Randomized Trial Completed NCT01180179 Phase 4 Lansoprazole;Famotidine
20 Comparison of Dexlansoprazole-based Triple and Rabeprazole-based Triple Therapies for Helicobacter Pylori Infection Completed NCT02541786 Phase 4 dexlansoprazole based triple therapy;rabeprazole-based triple therapy
21 Does Acetaminophen Potentiate the Gastroduodenal Mucosal Injury of Aspirin? A Prospective, Randomized, Pilot Study. Completed NCT00594867 Phase 4 Acetaminophen - 4 grams per day + Placebo;Aspirin - 325 mg per day + Placebo;Acetaminophen 4 gram per day + Aspirin 325 mg per day
22 Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit Completed NCT00633035 Phase 4 esomeprazole 40 mg;famotidine 20 mg
23 Sup-Icu RENal (SIREN) - a Sub-analysis of the Prospective SUP (Stress Ulcer Prophylaxis)-ICU Trial on the Risk of GI- Bleeding in ICU Patients Receiving Renal Replacement Therapy Completed NCT02718261 Phase 4 Pantoprazole;Saline 0.9% (matching placebo)
24 A Clinico-Bacteriological Study and Effect of Stress Ulcer Prophylaxis on Occurrence of Ventilator Associated Pneumonia: a Randomized Prospective Study Completed NCT00702871 Phase 4 Ranitidine;Sucralfate
25 Improving Multivitamin Supplementation to Pregnant Women Completed NCT02300155 Phase 4 Pregvit®;Orifer F®
26 Ivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan Completed NCT02241044 Phase 4
27 Comparison Between Hybrid, Reverse Hybrid, and Non-Bismuth Levofloxacin Quadruple Regimens for Helicobacter Pylori Infection in Egypt: A Randomized Controlled Trial Completed NCT04039412 Phase 4 Hybrid regimen;Reverse hybrid regimen;Levofloxacin quadruple regimen
28 Effects of Esomeprazole on Gastric Emptying of Alcoholic Beverages, Blood Alcohol Concentrations, Gastroesophageal Reflux and Release of Some Gastrointestinal Hormones in Healthy Volunteers Completed NCT00472550 Phase 4 esomeprazole 20 mg
29 Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients: an Open-Labelled Randomized Controlled Trial Completed NCT00610324 Phase 4 Chlorhexidine gluconate;Potassium permanganate
30 The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers: A Randomized, Parallel-controlled Multi-center Study Recruiting NCT03342456 Phase 4 Doxycycline Hyclate Enteric-Coated Capsules;Amoxicillin Capsules;Ilaprazole Enteric-Coated Tablets;Furazolidone Tablets;Potassium Citrate Tablets
31 Stress Ulcer Prophylaxis Versus Placebo - a Blinded Randomized Control Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease Recruiting NCT03667703 Phase 4 Ranitidine;Placebo
32 Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features in a Primary Care Setting: A Pragmatic, Randomized, Single Blind Study Recruiting NCT04028466 Phase 4 Vonoprazan;Omeprazole
33 Effect of Adding Azithromycin to Dexamethasone in Preventing Post-operative Nausea and Vomiting in Caesarean Section Under Spinal Anesthesia With Spinal Opiate. Not yet recruiting NCT03165123 Phase 4 Oral Azithromycin tablet;Intravenous dexamethasone
34 A Prospective, Randomized, Double-Blind Protocol to Compare the Efficacy of Lansoprazole to Ranitidine in Healing Pre-Existing and/or Preventing the Development of Gastroduodenal Stress Ulceration and Postoperative Bleeding in Patients Undergoing Elective Coronary Artery Bypass Graft or Cardiac Valve Replacement Surgery Terminated NCT00220909 Phase 4 Lansoprazole
35 Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis in Patients After Major Abdominal Surgery Terminated NCT00839488 Phase 4 pantoprazole 40 mg iv;famotidine 20 mg iv
36 Comparative Effectiveness of the Eradication of Helicobacter Pylori and an Inhibitor of Pump With Proton Versus Control on the Gastric Lesions Induced by the Aspirin With the Low Dose Among Patients Treated With the Long Course Withdrawn NCT00713947 Phase 4 during one week for the active treatments;Pantoprazole;Placebo Formula 515
37 A Prospective, Randomized Trial Comparing the Effect of Intravenous Omeprazole to That of Intravenous Ranitidine on the Maintenance of Hemostasis After Successful Endoscopic Treatment of Bleeding Peptic Ulcer Withdrawn NCT00247130 Phase 4 Omeprazole;Ranitidine
38 Ketorolac for Analgesia followiNG Autologous Breast RecOnstructiOn Withdrawn NCT03007381 Phase 4 Ketorolac Tromethamine;Normal Saline
39 Pediatric Intensive Care Ulcer Prophylaxis Pilot Trial Unknown status NCT02929563 Phase 3 Pantoprazole;Placebo (for pantoprazole)
40 Non Inferiority,Phase III,Multicentric,Double Blind,Randomized,Parallel Study,Comparing Dolamin Flex (Lysine Clonixinate+Cyclobenzaprine) and Tandrilax(Caffeine +Carisoprodol+Diclofenac+Paracetamol)in Pain Reduction in Patients With Lumbago Unknown status NCT01421433 Phase 3 Tandrilax;Dolamin Flex
41 Dual Therapy With High-Dose of Rabeprazole and Amoxicilline Versus Triple Therapy With Rabeprazole, Amoxicilline and Metronidazole as the Second Line Therapy for the Cure of H. Pylori Infection Unknown status NCT00197418 Phase 2, Phase 3 rabeprazole, amoxicillin, clarithromycin, metronidazole
42 Randomized Clinical Trial Comparing Gastric Partitioning Plus Gastro-entero Anastomosis Versus Gastro-entero Anastomosis Only in Patients With Unresectable and Obstructive Distal Gastric Cancer. Unknown status NCT02064803 Phase 3
43 The Phase 2 Study of FP-10, the Food Ingredient Derived From Milk Casein, on the Eradication Rates of Helicobacter Pylori by a Triple Therapy With Lansoprazole, Amoxicillin, and Clarithromycin Unknown status NCT00281047 Phase 2, Phase 3 FP-10
44 Pharmacogenomics-Based Tailor-Made Strategy for Eradication of Helicobacter Pylori Unknown status NCT00149084 Phase 3 Lansoprazole, clarithromycin, amoxicillin
45 Comparison Between the Effects of Intravenous Morphine, Tramadol and Ketorolac on Stress and Immune Responses in Patients Undergoing Modified Radical Mastectomy Unknown status NCT02449954 Phase 2, Phase 3 Intravenous morphine sulphate;Intravenous tramadol HCL;Intravenous ketorolac tromethamine
46 A Study to Investigate the Preventive Effect of AG-1749 Against the Recurrence of Gastric and Duodenal Ulcers During Long-term Treatment With Nonsteroid Anti-inflammatory Drug Completed NCT00787254 Phase 3 Lansoprazole;Gefarnate
47 A Phase III Multinational, Multicenter, Randomized, Double-blind, Parallel-group, Comparative Efficacy and Safety Study of D961H (20 mg Once Daily) Versus Placebo for Prevention of Gastric and/or Duodenal Ulcers Associated With Continuous Low-dose Aspirin (LDA) Use Completed NCT01069939 Phase 3 Esomeprazole;Placebo
48 A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Comparative Efficacy and Safety Study of Esomeprazole(20 mg Once Daily) Versus Placebo for the Prevention of Gastric and/or Duodenal Ulcers Associated With Daily Nonsteroidal Anti-inflammatory Drug (NSAID) Use Completed NCT00542789 Phase 3 Esomeprazole;Placebo
49 A Long Term Study to Investigate the Efficacy and Safety Study of D961H (Esomeprazole) (20 mg Once Daily) for the Prevention of Gastric and/or Duodenal Ulcers Associated With Daily Nonsteroidal Anti-inflammatory Drug (NSAID) Use Completed NCT00595517 Phase 3 Esomeprazole 20 mg
50 Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment. - A Multicenter, Randomized, Parallel-group, Double-blind Comparative Trial- Completed NCT01397448 Phase 2, Phase 3 E3810;E3810;Teprenone

Search NIH Clinical Center for Duodenal Ulcer

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Aluminum carbonate
Aluminum Hydroxide
Aluminum Hydroxide / Magnesium Hydroxide
Aluminum Hydroxide Gel
aluminum hydroxide, dried (USP)
basic aluminum carbonate gel
Calcium Carbonate
CALCIUM CARBONATE 1 g in 1 g ORAL POWDER
Calcium gluceptate
Cimetidine
Cimetidine Hydrochloride
dihydroxyaluminum sodium carbonate
Esomeprazole
Esomeprazole
Esomeprazole magnesium
esomeprazole sodium
Esomeprazole Strontium
Famotidine
Famotidine
lansoprazole
magaldrate
Magaldrate
Magnesium Hydroxide
Maprotiline
Maprotiline Hydrochloride
MILK OF MAGNESIA
Nizatidine
Nizatidine
Omeprazole
Omeprazole
Omeprazole 2 MG/ML Oral Suspension
Omeprazole magnesium
Pantoprazole
Prazepam
rabeprazole
Rabeprazole
Ranitidine
Sucralfate
Sucralfate

Cochrane evidence based reviews: duodenal ulcer

Genetic Tests for Duodenal Ulcer

Anatomical Context for Duodenal Ulcer

MalaCards organs/tissues related to Duodenal Ulcer:

41
Testes, Liver, Colon, Pancreas, Heart, Small Intestine, Lung

Publications for Duodenal Ulcer

Articles related to Duodenal Ulcer:

(show top 50) (show all 17010)
# Title Authors PMID Year
1
Associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease in Chinese Han population. 9 38
19804405 2010
2
Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in Pakistan. 9 38
19930551 2009
3
homB status of Helicobacter pylori as a novel marker to distinguish gastric cancer from duodenal ulcer. 9 38
19710266 2009
4
Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients. 9 38
19318661 2009
5
Serum antibodies positivity to 12 Helicobacter pylori virulence antigens in patients with benign or malignant gastroduodenal diseases--cross-sectional study. 9 38
19399945 2009
6
The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study. 9 38
19338650 2009
7
Helicobacter pylori cagA status and peptic ulcer disease in Iran. 9 38
18612816 2009
8
The prevalence of cagA and cagE genes in Helicobacter pylori strains isolated from different patient groups by polymerase chain reaction. 9 38
19260336 2008
9
Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. 9 38
18809506 2008
10
IL-4 -588C>T polymorphism and IL-4 receptor alpha [Ex5+14A>G; Ex11+828A>G] haplotype concur in selecting H. pylori cagA subtype infections. 9 38
18179773 2008
11
Effects of Helicobacter pylori Infection on gastric mucin expression. 9 38
18097286 2008
12
Stress ulcer prophylaxis in hospitalized patients not in intensive care units. 9 38
17592004 2007
13
Genetic polymorphisms of NOD1 and IL-8, but not polymorphisms of TLR4 genes, are associated with Helicobacter pylori-induced duodenal ulcer and gastritis. 9 38
17309748 2007
14
Helicobacter pylori cagA, vacA and iceA genotypes in northern Thai patients with gastric disease. 9 38
17539287 2007
15
Association between interleukin-1 gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in a Chinese population. 9 38
17295877 2007
16
The risk of pancreatic cancer in patients with gastric or duodenal ulcer disease. 9 38
17044024 2007
17
Analysis of serum antibody profile against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer. 9 38
17106939 2006
18
[Expression of gastrin, somatostatin, PCNA and Fas-L in the mucosa of gastric antrum of children with chronic gastritis and duodenal ulcer]. 9 38
17229384 2006
19
Detection of Helicobacter pylori cagA gene in gastric biopsies, clinical isolates and faeces. 9 38
16912439 2006
20
CagA positivity and its association with gastroduodenal disease in Turkish children undergoing endoscopic investigation. 9 38
16868800 2006
21
Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer. 9 38
16550552 2006
22
Assay of gastrin and somatostatin in gastric antrum tissues of children with chronic gastritis and duodenal ulcer. 9 38
16610039 2006
23
Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young Japanese. 9 38
16543737 2006
24
[The part of the hormone-cyclase system in achieving the therapeutic effect of hydrochloric acid secretion inhibitors at the duodenal ulcer]. 9 38
16866262 2006
25
IL1RN polymorphism and cagA-positive Helicobacter pylori strains increase the risk of duodenal ulcer in children. 9 38
16183821 2005
26
No allelic variant associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease. 9 38
16164697 2005
27
[Association of trefoil factor 1 expression with gastric mucosa injuries and gastric cancer]. 9 38
16174594 2005
28
A follow-up study on the effect of Helicobacter pylori eradication on the severity of gastric histology. 9 38
16110845 2005
29
The humoral immuneresponse to Helicobacter pylori infection in children with gastrointestinal symptoms. 9 38
15866217 2005
30
Relationship between trefoil factor 1 expression and gastric mucosa injuries and gastric cancer. 9 38
15849833 2005
31
Down-regulation of epithelial IL-8 responses in Helicobacter pylori-infected duodenal ulcer patients depends on host factors, rather than bacterial factors. 9 38
15762883 2005
32
Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome. 9 38
15652446 2005
33
Topographic expression of MUC5AC and MUC6 in the gastric mucosa infected by Helicobacter pylori and in associated diseases. 9 38
16325508 2005
34
[Gastrin-17 level in the omeprazole treatment of duodenal ulcer]. 9 38
17378383 2005
35
Genetic polymorphism of interleukin-8 (IL-8) is associated with Helicobacter pylori-induced duodenal ulcer. 9 38
15627645 2004
36
TNF/LTA polymorphisms and risk for gastric cancer/duodenal ulcer in the Korean population. 9 38
15381184 2004
37
High prevalence of multiple strain colonization of Helicobacter pylori in Korean patients: DNA diversity among clinical isolates from the gastric corpus, antrum and duodenum. 9 38
15053036 2004
38
Lewis antigen expression in gastric mucosa of children: relationship with Helicobacter pylori infection. 9 38
14676601 2004
39
Helicobacter pylori-induced immunological responses in patients with duodenal ulcer and in patients with cardiomyopathies. 9 38
15571071 2004
40
The diversity of vacA and cagA genes of Helicobacter pylori in East Asia. 9 38
14734191 2004
41
Association of interleukin 1 gene family polymorphisms with duodenal ulcer disease. 9 38
14632761 2003
42
Polymorphisms and the pocketbook: the cost-effectiveness of cytochrome P450 2C19 genotyping in the eradication of Helicobacter pylori infection associated with duodenal ulcer. 9 38
14615467 2003
43
[Effect of quamatel on neutrophil properties, parameters of lipid peroxidation and the antioxidant defense system in blood of patients with duodenal ulcer and pancreatitis]. 9 38
14743716 2003
44
History in our lifetime: the changing nature of refractory duodenal ulcer in the era of histamine H2 receptor antagonists. 9 38
14567455 2003
45
Local and peripheral cytokine response and CagA status of Helicobacter pylori-positive patients with duodenal ulcer. 9 38
14656687 2003
46
Helicobacter pylori genotypes and expression of gastritis in erosive gastro-oesophageal reflux disease. 9 38
12795459 2003
47
DNA-level characterization of Helicobacter pylori strains from patients with overt disease and with benign infections in Bangladesh. 9 38
12734242 2003
48
Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer. 9 38
12741450 2003
49
[Association between Helicobacter pylori virulence and duodenal ulcer disease in patients from Hong Kong in China]. 9 38
12697114 2003
50
Lack of association between pro-inflammatory genotypes of the interleukin-1 (IL-1B -31 C/+ and IL-1RN *2/*2) and gastric cancer/duodenal ulcer in Korean population. 9 38
12788304 2003

Variations for Duodenal Ulcer

Expression for Duodenal Ulcer

Search GEO for disease gene expression data for Duodenal Ulcer.

Pathways for Duodenal Ulcer

Pathways related to Duodenal Ulcer according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 TNF LTA INS IL1B CXCL8
2
Show member pathways
12.12 TNF LTA IL1B CXCL8
3
Show member pathways
12.11 TNF S100A8 IL1B CXCL8
4
Show member pathways
11.92 TNF LTA IL1B
5 11.88 TNF IL1B CXCL8
6
Show member pathways
11.87 TNF IL1RN IL1B CXCL8
7 11.84 TNF IL1B CXCL8
8 11.82 TNF LTA IL1B
9 11.79 INS IL1B CXCL8
10 11.76 TNF IL1B CXCL8
11 11.76 TNF IL1B CXCL8
12 11.76 TNF SST IL1RN IL1B CXCL8
13 11.7 TNF IL1B CXCL8
14 11.63 TNF LTA IL1B
15 11.59 TNF IL1B CXCL8
16 11.57 TNF LTA IL1B CXCL8
17 11.55 TNF IL1RN IL1B
18
Show member pathways
11.49 TNF IL1B CXCL8
19 11.47 TNF IL1B CXCL8
20 11.38 TNF IL1B CXCL8
21 11.23 TNF IL1B CXCL8
22 10.98 TNF IL1B
23 10.95 TNF IL1RN IL1B CXCL8
24 10.94 TNF LTA IL1B CXCL8
25 10.91 TNF CXCL8
26 10.82 TNF IL1B
27 10.13 HRH2 GAST
28 9.77 SCT GRP GAST CCK

GO Terms for Duodenal Ulcer

Cellular components related to Duodenal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TNF SST SCT S100A8 LTA INS
2 extracellular region GO:0005576 9.44 TNF SST SCT S100A8 LTA INS
3 secretory granule lumen GO:0034774 9.33 S100A8 INS GRP

Biological processes related to Duodenal Ulcer according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.94 TNF IL1RN IL1B CXCL8
2 inflammatory response GO:0006954 9.92 TNF S100A8 IL1RN IL1B CXCL8
3 cell-cell signaling GO:0007267 9.91 SST LTA INS IL1B
4 immune response GO:0006955 9.91 TNF LTA IL1RN IL1B HRH2 CXCL8
5 cellular response to lipopolysaccharide GO:0071222 9.84 TNF IL1RN IL1B CXCL8
6 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.81 TNF S100A8 CCK
7 positive regulation of JNK cascade GO:0046330 9.8 TNF IL1RN IL1B
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.78 TNF S100A8 INS IL1B
9 positive regulation of interleukin-6 production GO:0032755 9.76 TNF IL1RN IL1B
10 positive regulation of interferon-gamma production GO:0032729 9.72 TNF LTA IL1B
11 neutrophil chemotaxis GO:0030593 9.71 S100A8 IL1RN IL1B CXCL8
12 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.67 TNF IL1B
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 TNF IL1B
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.66 TNF IL1B
15 negative regulation of growth of symbiont in host GO:0044130 9.65 TNF LTA
16 response to drug GO:0042493 9.65 SST LTA
17 regulation of protein secretion GO:0050708 9.65 TNF INS
18 wound healing GO:0042060 9.64 S100A8 INS
19 positive regulation of peptide hormone secretion GO:0090277 9.62 INS GRP
20 positive regulation of chemokine biosynthetic process GO:0045080 9.62 TNF IL1B
21 response to glucocorticoid GO:0051384 9.61 TNF IL1RN
22 regulation of establishment of endothelial barrier GO:1903140 9.6 TNF IL1B
23 positive regulation of neuroinflammatory response GO:0150078 9.59 TNF IL1B
24 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.58 TNF LTA
25 positive regulation of fever generation GO:0031622 9.57 TNF IL1B
26 sequestering of triglyceride GO:0030730 9.56 TNF IL1B
27 G protein-coupled receptor signaling pathway GO:0007186 9.56 SST SCT INS HRH2 GRP GAST
28 embryonic digestive tract development GO:0048566 9.54 TNF SCT CXCL8
29 positive regulation of glial cell proliferation GO:0060252 9.5 TNF LTA IL1B
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 TNF IL1B
31 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.46 TNF LTA
32 negative regulation of lipid catabolic process GO:0050995 9.43 TNF INS IL1B
33 positive regulation of JUN kinase activity GO:0043507 9.21 TNF
34 memory GO:0007613 9.16 HRH2 CCK
35 chronic inflammatory response to antigenic stimulus GO:0002439 8.32 TNF
36 signal transduction GO:0007165 10.21 LTA IL1B HRH2 GRP GAST CXCL8

Molecular functions related to Duodenal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 TNF LTA IL1RN IL1B CXCL8
2 interleukin-1 receptor binding GO:0005149 9.16 IL1RN IL1B
3 hormone activity GO:0005179 9.02 SST SCT INS GAST CCK

Sources for Duodenal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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