MCID: DDN006
MIFTS: 48

Duodenitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenitis

MalaCards integrated aliases for Duodenitis:

Name: Duodenitis 12 55 44 15 73
Hemorrhagic Duodenitis 12 73
Acute Enteritis of the Mouse Intestinal Tract 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8643
ICD10 33 K29.8
ICD9CM 35 535.6
MeSH 44 D004382
NCIt 50 C94409
SNOMED-CT 68 155715004 72007001

Summaries for Duodenitis

MalaCards based summary : Duodenitis, also known as hemorrhagic duodenitis, is related to duodenal ulcer and duodenal disease. An important gene associated with Duodenitis is GAST (Gastrin), and among its related pathways/superpathways are Downstream signaling events of B Cell Receptor (BCR) and Secretion of Hydrochloric Acid in Parietal Cells. The drugs Lansoprazole and Ranitidine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and colon, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 76 Duodenitis is inflammation of the duodenum. It may persist acutely or... more...

Related Diseases for Duodenitis

Diseases related to Duodenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 590)
# Related Disease Score Top Affiliating Genes
1 duodenal ulcer 33.4 GAST INS
2 duodenal disease 33.2 ATP12A ATP4A
3 peptic ulcer disease 31.7 ATP4A GAST
4 superior mesenteric artery syndrome 31.7 ATP12A ATP4A
5 multiple endocrine neoplasia, type i 31.2 GAST INS
6 gastrinoma 30.7 GAST INS
7 islet cell tumor 29.7 GAST INS
8 peptic esophagitis 29.6 ATP12A ATP4A
9 bile reflux 29.6 ATP12A ATP4A
10 hernia, hiatus 29.5 ATP12A ATP4A
11 esophageal varix 29.5 ATP12A ATP4A
12 granulomatous gastritis 29.4 ATP12A ATP4A GAST
13 pneumatosis cystoides intestinalis 29.4 ATP12A ATP4A
14 gastric antral vascular ectasia 29.2 ATP12A ATP4A
15 esophageal candidiasis 29.2 ATP12A ATP4A
16 gastric lymphoma 29.2 ATP12A ATP4A
17 laryngitis 29.1 ATP12A ATP4A
18 polyposis, skin pigmentation, alopecia, and fingernail changes 29.0 ATP12A ATP4A
19 pancreatic steatorrhea 29.0 ATP12A ATP4A
20 diarrhea 29.0 CD79A GAST TMPRSS15
21 microscopic colitis 28.9 ATP12A CD79A
22 esophagitis, eosinophilic, 1 28.8 ATP12A ATP4A
23 cloacal exstrophy 28.8 ATP12A ATP4A
24 peptic ulcer perforation 28.6 ATP12A ATP4A GAST
25 jejunoileitis 28.2 ATP12A ATP4A CD79A
26 lymphocytic colitis 27.8 ATP12A ATP4A CD79A
27 lymphoma, mucosa-associated lymphoid type 27.5 ATP12A ATP4A CD79A MALT1
28 duodenal atresia 12.5
29 duodenal obstruction 12.1
30 duodenal gastrinoma 12.1
31 duodenal somatostatinoma 12.1
32 feingold syndrome 1 12.0
33 chronic duodenal ileus 12.0
34 neurofibromatosis-pheochromocytoma-duodenal carcinoid syndrome 12.0
35 tremor, nystagmus, and duodenal ulcer 11.9
36 duodenum cancer 11.9
37 duodenal ulcer due to antral g-cell hyperfunction 11.9
38 pancreatic lipomatosis duodenal stenosis 11.9
39 duodenal ulcer, hyperpepsinogenemic i 11.8
40 duodenal atresia tetralogy of fallot 11.8
41 pancreas, annular 11.6
42 diarrhea 5, with tufting enteropathy, congenital 11.0
43 chronic erosive gastritis 11.0
44 stromme syndrome 11.0
45 solitary median maxillary central incisor 10.8
46 familial adenomatous polyposis 1 10.8
47 xanthinuria, type i 10.8
48 xanthinuria, type ii 10.8
49 feingold syndrome 2 10.8
50 pancreatic lipase deficiency 10.8

Comorbidity relations with Duodenitis via Phenotypic Disease Network (PDN): (show all 16)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Atrophic Gastritis
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Esophageal Disease Esophagitis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Paralytic Ileus

Graphical network of the top 20 diseases related to Duodenitis:



Diseases related to Duodenitis

Symptoms & Phenotypes for Duodenitis

MGI Mouse Phenotypes related to Duodenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.46 ATP12A ATP4A GAST INS
2 homeostasis/metabolism MP:0005376 9.43 ATP12A ATP4A CD79A GAST INS TMPRSS15
3 immune system MP:0005387 9.1 ATP4A CD79A GAST INS MALT1 TMPRSS15

Drugs & Therapeutics for Duodenitis

Drugs for Duodenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
2
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055
3
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
4 Gastrointestinal Agents Phase 4,Phase 3
5 Antacids Phase 4,Phase 3
6 Proton Pump Inhibitors Phase 4,Phase 3
7 Anti-Ulcer Agents Phase 4,Phase 3
8 Ranitidine bismuth citrate Phase 4
9
Naproxen Approved, Vet_approved Phase 3 22204-53-1 1302 156391
10
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 4594 9579578
11
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
12
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
13
Ofloxacin Approved Phase 3 82419-36-1 4583
14
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
15
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
16 Analgesics Phase 3
17 Cyclooxygenase Inhibitors Phase 3
18 Analgesics, Non-Narcotic Phase 3
19 Peripheral Nervous System Agents Phase 3
20 Anti-Inflammatory Agents Phase 3
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3
22 Antirheumatic Agents Phase 3
23 Renal Agents Phase 3
24 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
25 Cytochrome P-450 Enzyme Inhibitors Phase 3
26 Topoisomerase Inhibitors Phase 3
27 Anti-Bacterial Agents Phase 3
28 Anti-Infective Agents Phase 3
29 Antiparasitic Agents Phase 3
30 Antiprotozoal Agents Phase 3
31 Antimalarials Phase 3
32
Ticlopidine Approved 55142-85-3 5472
33
Clopidogrel Approved 120202-66-6, 113665-84-2 60606
34
Warfarin Approved 81-81-2 6691 54678486
35
Iron Approved Not Applicable 7439-89-6 23925
36
Phenprocoumon Approved, Investigational 435-97-2 9908 54680692
37
Aspirin Approved, Vet_approved 50-78-2 2244
38
Rivaroxaban Approved 366789-02-8
39
Dipyridamole Approved 58-32-2 3108
40
Ticagrelor Approved 274693-27-5 9871419
41
Menadione Approved, Nutraceutical 58-27-5 4055
42
Serine Approved, Nutraceutical 56-45-1 5951
43
Phytonadione Approved, Investigational, Nutraceutical 84-80-0 4812 5284607
44
protease inhibitors
45 Serine Proteinase Inhibitors
46 HIV Protease Inhibitors
47 Vitamins
48 Platelet Aggregation Inhibitors
49 Anticoagulants
50 Factor Xa Inhibitors

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Lansoprazole Preventing Gastroduodenal Stress Ulcerations Terminated NCT00220909 Phase 4 Lansoprazole
2 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT01129011 Phase 3 PN400 (VIMOVO);Naproxen
3 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT00527787 Phase 3 PN400 (VIMOVO);Naproxen
4 A Two Week Nitazoxanidebased Quadruple Regimen Recruiting NCT02621359 Phase 3 Nitazoxanide;Levofloxacin;Doxycyclin;Omeprazole
5 Is a Reporting System for Gastritis or Duodenitis (Modified Lanza Scale) Reproducible? Completed NCT00852150
6 Effectiveness of Biofeedback-Assisted Relaxation Training in Children With Eosinophilic Duodenitis Completed NCT00124501 Not Applicable
7 Usefulness of Fecal Immunochemical Test in Iron Deficiency Anemia (IDAFIT) Recruiting NCT02792023 Not Applicable
8 Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK) Recruiting NCT01947998 Rivaroxaban (Xarelto, Bay59-7939);Warfarin;Antiplatelet drugs
9 Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands) Recruiting NCT01947985 Rivaroxoban (Xarelto, Bay59-7939);Standard of care
10 Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Germany) Active, not recruiting NCT01947959 Rivaroxaban (Xarelto, Bay59-7939);Standard of care
11 Helicobacter Pylori Infection in Renal Transplant Patients Not yet recruiting NCT03310255

Search NIH Clinical Center for Duodenitis

Cochrane evidence based reviews: duodenitis

Genetic Tests for Duodenitis

Anatomical Context for Duodenitis

MalaCards organs/tissues related to Duodenitis:

41
Pancreas, Testes, Colon, Liver, Small Intestine, T Cells, Kidney

Publications for Duodenitis

Articles related to Duodenitis:

(show top 50) (show all 3182)
# Title Authors Year
1
Cerebral infarction following cyanoacrylate endoscopic therapy of duodenal varices in a patient with a patent foramen ovale. ( 29948836 )
2018
2
Reply to the Letter by Dr. Antonio Ponzetto Regarding "The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding". ( 29791893 )
2018
3
A Case of Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall. ( 29434146 )
2018
4
Metastatic Cutaneous Duodenal Gastrointestinal Stromal Tumor: A Possible Clue to Multiple Metastases. ( 29853751 )
2018
5
Laparoscopic omental filling with intraoperative endoscopy for a perforated duodenal ulcer. ( 29869066 )
2018
6
Endoscopic transluminal water irrigation for duodenal diverticulitis. ( 29969797 )
2018
7
Gastric Outlet and Duodenal Obstruction as a Complication of Migrated Gastrostomy Tube: Report of Two Cases and Literature Review. ( 29511412 )
2018
8
Risk factors for advanced duodenal and ampullary adenomatosis in familial adenomatous polyposis: a prospective, single-center study. ( 29713679 )
2018
9
Equine duodenitis-proximal jejunitis: A review. ( 29904204 )
2018
10
Atypical perioperative management for duodenal obstruction in an infant with heterotaxy syndrome: a case report. ( 29479560 )
2018
11
A rare complication of recurrent duodenal ulcer. ( 29549042 )
2018
12
Safety of cold snare polypectomy for duodenal adenomas in familial adenomatous polyposis: a prospective exploratory study. ( 29351704 )
2018
13
Cytology Preparations of Formalin Fixative Aid Detection of Giardia in Duodenal Biopsy Samples: A Helpful Tool for Diagnosing Esophageal Candidiasis as Well? ( 29762142 )
2018
14
Tailored surgical treatment of duodenal polyposis in familial adenomatous polyposis syndrome. ( 29331402 )
2018
15
Double Duodenal Atresia: An Extremely Rare Presentation of Duodenal Obstruction. ( 29314383 )
2018
16
Ten-Year Experience of Managing Giant Duodenal Ulcer Perforations with Triple Tube Ostomy at Tertiary Hospital of North India. ( 29581678 )
2018
17
Giant Duodenal Lipoma: a Rare Cause of Vomiting, Anorexia, Unintentional Weight Loss, and Duodenal Intussusception. ( 29797145 )
2018
18
In with acute bronchitis; out with duodenal perforation: the potentially harmful cascade of over-testing. A case report. ( 29441163 )
2018
19
Comparisons Between Bacterial Communities in Mucosa in Patients With Gastric Antrum Ulcer and a Duodenal Ulcer. ( 29868487 )
2018
20
Strongyloides Duodenitis in an Immunosuppressed Patient with Lupus Nephritis. ( 29844853 )
2018
21
Pancreaticoduodenectomy for the Management of Pancreatic or Duodenal Metastases from Primary Sarcoma. ( 29970529 )
2018
22
Prevalence of Helicobacter pylori and its CagA subtypes in gastric cancer and duodenal ulcer at an Austrian tertiary referral center over 25 years. ( 29813089 )
2018
23
A rare mass in the duodenal bulb: Brunner's glands cystadenoma. ( 29368943 )
2018
24
Management of a postbulbar duodenal ulcer and stricture causing gastric outlet obstruction: A case report. ( 29692890 )
2018
25
New single capsule of bismuth, metronidazole and tetracycline given with omeprazole versus quadruple therapy consisting of bismuth, omeprazole, amoxicillin and clarithromycin for eradication of Helicobacter pylori in duodenal ulcer patients: a Chinese prospective, randomized, multicentre trial. ( 29596646 )
2018
26
Does Bismuth Subgallate Affect Smell and Stool Character? A Randomized Double-Blinded Placebo-Controlled Trial of Bismuth Subgallate on Loop Duodenal Switch Patients with Complaints of Smelly Stools and Diarrhea. ( 29956108 )
2018
27
Duodenal Ulcer as a Postoperative Complication in the Donor in Living-Donor Liver Transplantation. ( 29731079 )
2018
28
Gastrointestinal: Duodenal variceal bleeding secondary to thrombophilia-related portal vein thrombosis. ( 29372608 )
2018
29
Unusual Presentation of Duodenal Ulcer Presenting with Duodenal Intussusception. ( 29619400 )
2018
30
Duodenal amyloidosis secondary to ulcerative colitis. ( 29422811 )
2018
31
Gastrointestinal: Ulcerative colitis-associated duodenitis. ( 29659081 )
2018
32
Phytobezoar and duodenal ulcer as complication of Duodopa therapy in a patient affected by Parkinson's disease. ( 29960957 )
2018
33
Hepatobiliary and Pancreatic: Segmental arterial mediolysis of pancreaticoduodenal artery accompanied by acute pancreatitis and duodenal obstruction. ( 29691909 )
2018
34
Containing the Costs of Recurrent Gastro-Duodenal Ulcer Bleeding. ( 29791892 )
2018
35
Duodenal mucinous adenocarcinoma presenting as ileus, obstructive jaundice and massive ascites: A case report. ( 29456851 )
2018
36
Molecular Predicators of Duodenal Familial Adenomatous Polyposis Chemoprevention: Do Chemopreventive Drugs Hit Their Presumed Molecular Targets? ( 29263155 )
2018
37
Total Bile Acid Concentration in duodenal fluid Is a Useful Preoperative Screening Marker to Rule Out Biliary Atresia. ( 29851770 )
2018
38
Duodenal Scalloping Diagnoses WaldenstrAPm Macroglobulinemia. ( 29660526 )
2018
39
Duodenal Pyloric Gland Adenoma in a 59-Year-Old Asian Male. ( 29971172 )
2018
40
Application of Jejunal Nutrient Tube in Congenital Duodenal Obstruction in Children. ( 29900152 )
2018
41
The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding. ( 29342468 )
2018
42
International study of endoscopic management of distal malignant biliary obstruction combined with duodenal obstruction. ( 28982258 )
2018
43
Efficacy and Tolerability of Two Quadruple Regimens: Bismuth, Omeprazole, Metronidazole with Amoxicillin or Tetracycline as First-Line Treatment for Eradication of Helicobacter Pylori in Patients with Duodenal Ulcer: A Randomized Clinical Trial. ( 29889843 )
2018
44
<i>Gemella haemolysans</i> bacteremia in a patient with secondary peritonitis due to a duodenal ulcer perforation: A case report. ( 29942771 )
2018
45
An unusual case of duodenal metastasis of pulmonary pleomorphic carcinoma. ( 29391323 )
2018
46
Duodenal lengthening in an adult with ultra-short bowel syndrome. A case report. ( 29106286 )
2018
47
Teratoma Arising from Hepato Duodenal Ligament in the Newborn with Transection of Portal Vein, Hepatic Artery and Common Bile Duct: A Surgical Challenge. ( 29386766 )
2018
48
Neonatal echocardiogram in duodenal obstruction is unnecessary after normal fetal cardiac imaging. ( 29866484 )
2018
49
Application of over-the-scope clip for massive duodenal ulcer bleeding in a 4-year-old boy weighing 7.8 kg. ( 29169193 )
2018
50
Megaduodenum in a 59-year-old man: a very late postoperative complication after duodenal atresia. ( 29351932 )
2018

Variations for Duodenitis

Expression for Duodenitis

Search GEO for disease gene expression data for Duodenitis.

Pathways for Duodenitis

Pathways related to Duodenitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 CD79A INS MALT1
2 9.32 ATP4A GAST

GO Terms for Duodenitis

Biological processes related to Duodenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import GO:0010107 9.4 ATP12A ATP4A
2 B cell activation GO:0042113 9.37 CD79A MALT1
3 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
6 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Duodenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Duodenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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