MCID: DDN006
MIFTS: 43

Duodenitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenitis

MalaCards integrated aliases for Duodenitis:

Name: Duodenitis 12 55 44 15 73
Hemorrhagic Duodenitis 12 73
Acute Enteritis of the Mouse Intestinal Tract 73

Classifications:



External Ids:

Disease Ontology 12 DOID:8643
ICD10 33 K29.8
ICD9CM 35 535.6
MeSH 44 D004382
NCIt 50 C94409
SNOMED-CT 68 72007001

Summaries for Duodenitis

MalaCards based summary : Duodenitis, also known as hemorrhagic duodenitis, is related to duodenal ulcer and duodenal disease. An important gene associated with Duodenitis is GAST (Gastrin), and among its related pathways/superpathways is Secretion of Hydrochloric Acid in Parietal Cells. The drugs Dexlansoprazole and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and t cells, and related phenotype is digestive/alimentary.

Wikipedia : 76 Duodenitis is inflammation of the duodenum. It may persist acutely or... more...

Related Diseases for Duodenitis

Diseases related to Duodenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 704)
# Related Disease Score Top Affiliating Genes
1 duodenal ulcer 33.7 GAST INS
2 duodenal disease 33.3 ATP12A ATP4A
3 peptic ulcer disease 32.4 ATP4A GAST
4 superior mesenteric artery syndrome 32.0 ATP12A ATP4A
5 multiple endocrine neoplasia, type i 31.8 GAST INS
6 gastrinoma 30.5 GAST INS
7 peptic esophagitis 30.3 ATP12A ATP4A
8 active peptic ulcer disease 30.1 ATP12A ATP4A
9 granulomatous gastritis 29.9 ATP12A ATP4A GAST
10 hernia, hiatus 29.8 ATP12A ATP4A
11 lymphoma, mucosa-associated lymphoid type 29.8 ATP12A ATP4A MALT1
12 esophageal varix 29.7 ATP12A ATP4A
13 islet cell tumor 29.7 GAST INS
14 pneumatosis cystoides intestinalis 29.6 ATP12A ATP4A
15 microinvasive gastric cancer 29.6 ATP12A ATP4A
16 bile reflux 29.6 ATP12A ATP4A
17 microscopic colitis 29.5 ATP12A ATP4A
18 peptic ulcer perforation 29.4 ATP12A ATP4A GAST
19 gastric lymphoma 29.4 ATP12A ATP4A
20 blind loop syndrome 29.4 ATP12A ATP4A
21 esophagitis, eosinophilic, 1 29.4 ATP12A ATP4A
22 gastrointestinal system disease 29.3 ATP12A ATP4A GAST INS
23 gastric antral vascular ectasia 29.3 ATP12A ATP4A
24 esophageal candidiasis 29.3 ATP12A ATP4A
25 laryngitis 29.3 ATP12A ATP4A
26 lymphocytic colitis 29.2 ATP12A ATP4A
27 chronic intestinal vascular insufficiency 29.2 ATP12A ATP4A
28 polyposis, skin pigmentation, alopecia, and fingernail changes 29.2 ATP12A ATP4A
29 pancreatic steatorrhea 29.2 ATP12A ATP4A
30 pancreas disease 29.2 GAST INS
31 cloacal exstrophy 29.1 ATP12A ATP4A
32 gastric neuroendocrine neoplasm 29.1 ATP12A ATP4A GAST
33 duodenal atresia 12.7
34 duodenal obstruction 12.3
35 duodenal gastrinoma 12.2
36 duodenal somatostatinoma 12.2
37 feingold syndrome 1 12.2
38 chronic duodenal ileus 12.1
39 neurofibromatosis-pheochromocytoma-duodenal carcinoid syndrome 12.1
40 tremor, nystagmus, and duodenal ulcer 12.1
41 duodenum cancer 12.1
42 duodenal ulcer due to antral g-cell hyperfunction 12.0
43 pancreatic lipomatosis duodenal stenosis 12.0
44 duodenal ulcer, hyperpepsinogenemic i 11.9
45 duodenal atresia tetralogy of fallot 11.9
46 pancreas, annular 11.8
47 duodenum adenocarcinoma 11.6
48 diarrhea 5, with tufting enteropathy, congenital 11.1
49 chronic erosive gastritis 11.1
50 stromme syndrome 11.1

Comorbidity relations with Duodenitis via Phenotypic Disease Network (PDN): (show all 16)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Atrophic Gastritis
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Esophageal Disease Esophagitis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Paralytic Ileus

Graphical network of the top 20 diseases related to Duodenitis:



Diseases related to Duodenitis

Symptoms & Phenotypes for Duodenitis

MGI Mouse Phenotypes related to Duodenitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 ATP12A ATP4A GAST INS

Drugs & Therapeutics for Duodenitis

Drugs for Duodenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
2
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
3
Ranitidine Approved Phase 4 66357-35-5, 66357-59-3 3001055
4 Antacids Phase 4,Phase 3,Not Applicable
5 Anti-Ulcer Agents Phase 4,Phase 3,Not Applicable
6 Proton Pump Inhibitors Phase 4,Phase 3,Not Applicable
7 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
8 Ranitidine bismuth citrate Phase 4
9
Naproxen Approved, Vet_approved Phase 3 22204-53-1 1302 156391
10
Esomeprazole Approved, Investigational Phase 3,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
11
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
12
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
13
Ofloxacin Approved Phase 3 82419-36-1 4583
14
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
15
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
16 Anti-Inflammatory Agents, Non-Steroidal Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Analgesics Phase 3
19 Peripheral Nervous System Agents Phase 3
20 Cyclooxygenase Inhibitors Phase 3
21 Antirheumatic Agents Phase 3
22 Analgesics, Non-Narcotic Phase 3
23 Anti-Infective Agents Phase 3
24 Antiparasitic Agents Phase 3
25 Cytochrome P-450 Enzyme Inhibitors Phase 3
26 Topoisomerase Inhibitors Phase 3
27 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
28 Anti-Bacterial Agents Phase 3
29 Antiprotozoal Agents Phase 3
30 Antimalarials Phase 3
31 Anti-Infective Agents, Urinary Phase 3
32 Renal Agents Phase 3
33
Iron Approved Not Applicable 7439-89-6 23925
34
Warfarin Approved 81-81-2 6691 54678486
35
Dipyridamole Approved 58-32-2 3108
36
Ticagrelor Approved 274693-27-5 9871419
37
Ticlopidine Approved 55142-85-3 5472
38
Phytonadione Approved, Investigational 84-80-0 4812 5284607
39
Clopidogrel Approved 113665-84-2, 120202-66-6 60606
40
Rivaroxaban Approved 366789-02-8
41
Aspirin Approved, Vet_approved 50-78-2 2244
42
Phenprocoumon Approved, Investigational 435-97-2 54680692 9908
43
Menadione Approved, Nutraceutical 58-27-5 4055
44
Serine Approved, Nutraceutical 56-45-1 5951
45 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
46 Hormone Antagonists Not Applicable
47 Gastrins Not Applicable
48 Hormones Not Applicable
49 Menaquinone
50 Vitamins

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Lansoprazole Preventing Gastroduodenal Stress Ulcerations Terminated NCT00220909 Phase 4 Lansoprazole
2 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT01129011 Phase 3 PN400 (VIMOVO);Naproxen
3 Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen Completed NCT00527787 Phase 3 PN400 (VIMOVO);Naproxen
4 A Two Week Nitazoxanidebased Quadruple Regimen Recruiting NCT02621359 Phase 3 Nitazoxanide;Levofloxacin;Doxycyclin;Omeprazole
5 Is a Reporting System for Gastritis or Duodenitis (Modified Lanza Scale) Reproducible? Completed NCT00852150
6 Effectiveness of Biofeedback-Assisted Relaxation Training in Children With Eosinophilic Duodenitis Completed NCT00124501 Not Applicable
7 The Effect of Esomeprazole on Type 2 Diabetes Completed NCT03598738 Not Applicable Esomeprazole 40mg
8 Usefulness of Fecal Immunochemical Test in Iron Deficiency Anemia (IDAFIT) Recruiting NCT02792023 Not Applicable
9 Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK) Recruiting NCT01947998 Rivaroxaban (Xarelto, Bay59-7939);Warfarin;Antiplatelet drugs
10 Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (Netherlands) Recruiting NCT01947985 Rivaroxoban (Xarelto, Bay59-7939);Standard of care
11 Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Practice (Germany) Active, not recruiting NCT01947959 Rivaroxaban (Xarelto, Bay59-7939);Standard of care
12 Helicobacter Pylori Infection in Renal Transplant Patients Not yet recruiting NCT03310255

Search NIH Clinical Center for Duodenitis

Cochrane evidence based reviews: duodenitis

Genetic Tests for Duodenitis

Anatomical Context for Duodenitis

MalaCards organs/tissues related to Duodenitis:

41
Testes, Pancreas, T Cells, Lung, Kidney, B Cells, Myeloid

Publications for Duodenitis

Articles related to Duodenitis:

(show top 50) (show all 287)
# Title Authors Year
1
Equine duodenitis-proximal jejunitis: A review. ( 29904204 )
2018
2
Strongyloides Duodenitis in an Immunosuppressed Patient with Lupus Nephritis. ( 29844853 )
2018
3
Gastrointestinal: Ulcerative colitis-associated duodenitis. ( 29659081 )
2018
4
Duodenitis, Diarrhea, and Death in a Patient with AIDS. ( 30259279 )
2018
5
Ischemic Duodenitis with Delayed Elevation of Pancreatic Enzymes. ( 29491304 )
2018
6
Sodium Polystyrene Sulfonate and Cytomegalovirus-Associated Hemorrhagic Duodenitis: More than Meets the Eye. ( 30072684 )
2018
7
Gastrointestinal Bleed from Erosive Gastritis and Duodenitis: A Sentinel Event of Invasive Lobular Carcinoma of the Breast and a Diagnostic Dilemma. ( 30094114 )
2018
8
Lethal phlegmonous duodenitis. ( 30124100 )
2018
9
Henoch-SchAPnlein Purpura with Concurrent Cytomegalovirus Duodenitis. ( 28271648 )
2017
10
Duodenitis-Proximal Jejunitis in Horses After Experimental Administration of Clostridium difficile Toxins. ( 27906466 )
2017
11
Multiple Duodenal Strictures due to Eosinophilic Duodenitis. ( 28270676 )
2017
12
Cytomegalovirus duodenitis in immunocompetent patients: what else should we look for? ( 28611166 )
2017
13
Celiac Disease and Other Causes of Duodenitis. ( 28758791 )
2017
14
Diffuse nodular duodenitis in a woman presenting with dyspepsia and weight loss. ( 29364111 )
2017
15
Cytomegalovirus duodenitis associated with life-threatening duodenal hemorrhage in an immunocompetent patient: A case report. ( 28292662 )
2017
16
An Atypical Case of Leishmaniasis Associated with Chronic Duodenitis in a Dog. ( 28282232 )
2017
17
Lymphocytic duodenitis or microscopic enteritis and gluten-related conditions: what needs to be explored? ( 28655974 )
2017
18
Cytomegalovirus Associated Duodenal Ulcer and Duodenitis in a Malnourished Pediatric Patient. ( 29119032 )
2017
19
Adult-Onset Henoch-Schonlein Purpura Duodenitis. ( 29038676 )
2017
20
Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators. ( 27729741 )
2016
21
Duodenitis in children. ( 27472477 )
2016
22
Acute Reversible Duodenitis Following Non-Therapeutic Upper Gastrointestinal Endoscopy. Is Duodenal Diverticulum a Predisposing Factor? ( 27994697 )
2016
23
The Prevalence of Duodenitis in Children. ( 27347719 )
2016
24
Chronological Endoscopic and Pathological Observations in Russell Body Duodenitis. ( 26999017 )
2016
25
Extensive ulcerative duodenitis caused by ischemia. ( 27459878 )
2016
26
An unusual case of gastritis and duodenitis after yttrium 90-microsphere selective internal radiation. ( 25595794 )
2015
27
Russell body duodenitis with immunoglobulin kappa light chain restriction. ( 25610537 )
2015
28
Suppurative Duodenitis and Superior Mesenteric Vein Thrombosis After Toothpick Ingestion. ( 25638588 )
2015
29
Prevalence, Clinical, Endoscopic and Pathological Features of Duodenitis In Children. ( 26252915 )
2015
30
A case of invasive cytomegalovirus duodenitis in an immunosuppressed patient 15A months after renal transplantation. ( 25582982 )
2015
31
Cytomegalovirus as an Insidious Pathogen Causing Duodenitis. ( 26490030 )
2015
32
Radiation-induced hemorrhagic duodenitis associated with sorafenib treatment. ( 25832768 )
2015
33
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
34
Severe diffuse duodenitis successfully treated with intravenous tacrolimus after colectomy for ulcerative colitis. ( 25366006 )
2014
35
Reversible acute duodenitis as a complication of endoscopic biliary stenting. ( 24689087 )
2014
36
Impact of Microscopic Duodenitis on Symptomatic Response to Helicobacter pylori Eradication in Functional Dyspepsia. ( 25102980 )
2014
37
Russell body gastritis/duodenitis: a case series and description of immunoglobulin light chain restriction. ( 25001185 )
2014
38
Cytomegalovirus duodenitis associated with acquired immunodeficiency syndrome. ( 23363302 )
2013
39
Herpes simplex virus duodenitis accompanying Crohn's disease. ( 24262595 )
2013
40
Acute segmentary ulcerative duodenitis induced by Streptococcus pyogenes mimicking inflammatory bowel disease. ( 23994254 )
2013
41
Obstructive Jaundice Secondary to Primary Duodenal Lymphoma with CMV Duodenitis Causing Upper GI Bleed in Retro-Positive Patient: A Case Report. ( 24426393 )
2013
42
Use of MRI to detect duodenal lesion caused by eosinophilic duodenitis. ( 23283623 )
2013
43
Co-existence of Sarcina Organisms and Helicobacter pylori Gastritis/Duodenitis in Pediatric Siblings. ( 25664331 )
2013
44
Russell body duodenitis in a patient with retroperitoneal metastasis of ureteral cancer. ( 23326174 )
2013
45
Confocal laser endomicroscopy for characterization of Crohn's disease-associated duodenitis. ( 22396293 )
2012
46
Duodenitis associated with non-steroidal anti-inflammatory drug use causing mesenteric panniculitis. ( 22524738 )
2012
47
Two cases of diffuse duodenitis associated with ulcerative colitis. ( 23119193 )
2012
48
An examination of the relationship between the endoscopic appearance of duodenitis and the histological findings in patients with epigastric pain. ( 22949941 )
2012
49
Necrotizing duodenitis caused by Clostridium perfringens type A in a Japanese young man. ( 23064579 )
2012
50
Russell body duodenitis: a histopathological and molecular approach to a rare clinical entity. ( 22673188 )
2012

Variations for Duodenitis

Expression for Duodenitis

Search GEO for disease gene expression data for Duodenitis.

Pathways for Duodenitis

Pathways related to Duodenitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.32 ATP4A GAST

GO Terms for Duodenitis

Biological processes related to Duodenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.4 ATP12A ATP4A
2 potassium ion import GO:0010107 9.37 ATP12A ATP4A
3 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP12A ATP4A
6 cellular potassium ion homeostasis GO:0030007 8.96 ATP12A ATP4A
7 sodium ion export across plasma membrane GO:0036376 8.62 ATP12A ATP4A

Molecular functions related to Duodenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.16 INS MALT1
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Duodenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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