MCID: DDN006
MIFTS: 49

Duodenitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenitis

MalaCards integrated aliases for Duodenitis:

Name: Duodenitis 12 54 43 15 71 32
Hemorrhagic Duodenitis 12 71
Acute Enteritis of the Mouse Intestinal Tract 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8643
ICD9CM 34 535.6
MeSH 43 D004382
NCIt 49 C94409
SNOMED-CT 67 72007001
ICD10 32 K29.8
UMLS 71 C0013298 C0341245 C1522057

Summaries for Duodenitis

MalaCards based summary : Duodenitis, also known as hemorrhagic duodenitis, is related to duodenal gastrinoma and duodenal ulcer. An important gene associated with Duodenitis is GAST (Gastrin), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. The drugs Lansoprazole and Dexlansoprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and colon, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 74 Duodenitis is inflammation of the duodenum. It may persist acutely or... more...

Related Diseases for Duodenitis

Diseases related to Duodenitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1662)
# Related Disease Score Top Affiliating Genes
1 duodenal gastrinoma 34.1 GAST ATP4A ATP12A
2 duodenal ulcer 34.1 TNF S100A8 INS GAST
3 chronic duodenal ileus 33.9 CRP ALB
4 duodenal obstruction 33.5 CRP ATP4A ATP12A ALB
5 duodenum disease 32.8 S100A8 GAST ATP4A ATP12A
6 gastrointestinal ulceration, recurrent, with dysfunctional platelets 32.6 S100A8 GAST
7 superior mesenteric artery syndrome 32.5 CRP ATP4A ATP12A
8 multiple endocrine neoplasia, type i 32.4 INS GAST ATP4A ATP12A
9 gastritis 32.0 TNF S100A8 GAST ATP4A
10 atrophic gastritis 31.6 TNF S100A8 GAST
11 peptic ulcer disease 31.6 TNF S100A8 INS GAST ATP4A ATP12A
12 gastric ulcer 31.5 TNF S100A8 GAST
13 zollinger-ellison syndrome 31.4 GAST ATP4A ATP12A
14 duodenogastric reflux 31.2 GAST ATP4A ATP12A
15 ileus 31.0 TNF INS CRP
16 gastrojejunal ulcer 30.9 ATP4A ATP12A
17 granulomatous gastritis 30.9 GAST ATP4A ATP12A
18 pancreatitis 30.8 TNF INS CRP ALB
19 peritonitis 30.7 TNF CRP ALB
20 obstructive jaundice 30.7 TNF CRP ALB
21 acute pancreatitis 30.7 TNF INS CRP ALB
22 gastroduodenitis 30.6 S100A8 GAST CD40LG CD4 ATP4A ATP12A
23 gastritis, familial giant hypertrophic 30.6 GAST ATP4A ATP12A ALB
24 esophageal varix 30.6 ATP4A ATP12A ALB
25 eosinophilic gastroenteritis 30.6 ATP4A ATP12A ALB
26 pernicious anemia 30.5 GAST ATP4A ATP12A
27 microinvasive gastric cancer 30.5 S100A8 GAST ATP4A ATP12A
28 intussusception 30.5 CRP CD40LG ALB
29 postgastrectomy syndrome 30.4 INS GAST ATP12A
30 active peptic ulcer disease 30.4 CRP ATP4A ATP12A ALB
31 hernia, hiatus 30.4 GAST CRP ATP4A ATP12A
32 dieulafoy lesion 30.4 ATP4A ATP12A
33 gastric dilatation 30.4 CRP ATP4A ATP12A
34 volvulus of midgut 30.4 CRP ATP4A ATP12A ALB
35 gastroesophageal reflux 30.4 TNF S100A8 GAST ATP4A ATP12A
36 pancreatic gastrinoma 30.4 GAST ATP4A ATP12A
37 blind loop syndrome 30.4 ATP4A ATP12A ALB
38 irritable bowel syndrome 30.3 TNF TGM2 CRP
39 gastroenteritis 30.3 TNF CRP ALB
40 rumination disorder 30.3 ATP4A ATP12A
41 primary hyperparathyroidism 30.2 INS GAST ALB
42 pulmonary tuberculosis 30.2 TNF CRP ALB
43 gallbladder disease 30.2 INS CRP ALB
44 colorectal adenoma 30.2 TNF INS CRP
45 optic papillitis 30.2 CRP CD40LG CD4
46 diarrhea 30.2 TNF TGM2 GAST CD40LG ALB
47 chronic intestinal vascular insufficiency 30.1 ATP4A ATP12A
48 ascending cholangitis 30.1 CRP ALB
49 cholangitis 30.1 TNF CRP CD40LG ALB
50 acute cholangitis 30.1 CRP ALB

Comorbidity relations with Duodenitis via Phenotypic Disease Network (PDN): (show all 13)


Active Peptic Ulcer Disease Acute Cystitis
Acute Pancreatitis Atrophic Gastritis
Bronchitis Deficiency Anemia
Esophageal Disease Esophagitis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Iron Deficiency Anemia
Paralytic Ileus

Graphical network of the top 20 diseases related to Duodenitis:



Diseases related to Duodenitis

Symptoms & Phenotypes for Duodenitis

MGI Mouse Phenotypes related to Duodenitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.91 ALB ATP4A CD4 CD40LG CD8A GAST
2 homeostasis/metabolism MP:0005376 9.9 ALB ATP12A ATP4A CD4 CD40LG CRP
3 digestive/alimentary MP:0005381 9.87 ALB ATP12A ATP4A CD4 GAST INS
4 immune system MP:0005387 9.7 ALB ATP4A CD4 CD40LG CD8A CRP
5 mortality/aging MP:0010768 9.4 ALB ATP4A CD4 CD40LG CD8A GAST

Drugs & Therapeutics for Duodenitis

Drugs for Duodenitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
2
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
3 Antacids Phase 4
4 Anti-Ulcer Agents Phase 4
5 Gastrointestinal Agents Phase 4
6 Proton Pump Inhibitors Phase 4
7 Ranitidine bismuth citrate Phase 4
8
Clarithromycin Approved Phase 3 81103-11-9 84029
9
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
10
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
11
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
12
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
13
Nitazoxanide Approved, Investigational, Vet_approved Phase 3 55981-09-4 41684
14
Ofloxacin Approved Phase 3 82419-36-1 4583
15 Anti-Inflammatory Agents Phase 3
16 Cytochrome P-450 CYP3A Inhibitors Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Immunoglobulins Phase 3
19 Antibodies Phase 3
20 Immunoglobulins, Intravenous Phase 3
21 Antibodies, Monoclonal Phase 3
22 Immunoglobulin G Phase 3
23 Cytochrome P-450 Enzyme Inhibitors Phase 3
24 Antiprotozoal Agents Phase 3
25 Antiparasitic Agents Phase 3
26 Antimalarials Phase 3
27
Rifaximin Approved, Investigational Phase 2 80621-81-4 6436173 46783403
28 Anti-Infective Agents Phase 2
29 Anti-Bacterial Agents Phase 2
30
Montelukast Approved 158966-92-8 5281040
31
Esomeprazole Approved, Investigational 161796-78-7, 119141-88-7, 161973-10-0 9568614 4594
32 Respiratory System Agents
33 Hormone Antagonists
34 Hormones
35 Leukotriene Antagonists
36 Anti-Asthmatic Agents
37 Gastrins

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-Blind Protocol to Compare the Efficacy of Lansoprazole to Ranitidine in Healing Pre-Existing and/or Preventing the Development of Gastroduodenal Stress Ulceration and Postoperative Bleeding in Patients Undergoing Elective Coronary Artery Bypass Graft or Cardiac Valve Replacement Surgery Terminated NCT00220909 Phase 4 Lansoprazole
2 Dyspeptic Symptoms Evolution After Eradication of Helicobacter Pylori in Patients With Different Endoscopic Findings: a Randomized Double-blind Placebo-controlled Clinical Trial With 12 Months of Follow-up Completed NCT00404534 Phase 3 Amoxicillin, Clarythromycin, Omeprazole for ten days
3 A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy and Safety of AK002 in Patients With Moderately to Severely Active Eosinophilic Gastritis and/or Eosinophilic Duodenitis (Formerly Referred to as Eosinophilic Gastroenteritis) Recruiting NCT04322604 Phase 3 antolimab (AK002)
4 A Two Week Nitazoxanidebased Quadruple Regimen for Helicobacter Pylori Therapy After Failure of Standard Triple Therapy: A Single Center Experience Recruiting NCT02621359 Phase 3 Nitazoxanide;Levofloxacin;Doxycyclin;Omeprazole
5 Multi-dimensional Clinical and Pathophysiological Profiles of Patients With Functional Dyspepsia and Effect of Gut Microbiota Manipulation Using Rifaximin for Its Treatment: A Randomized Controlled Trial Not yet recruiting NCT04302402 Phase 2 Rifaximin;Placebo
6 Food-Specific IgE, IgG, IgG4, Skin Prick Testing and Atopy Patch Testing in Children/Adolescents With Functional Dyspepsia: A Pilot Study Completed NCT00328679 Phase 1
7 Helicobacter Pylori Infection in Renal Transplant Patients Unknown status NCT03310255
8 Reproducibility of Modified Lanza Scale for the Reporting of Gastritis and Duodenitis Completed NCT00852150
9 The Impact of Biofeedback-Assisted Relaxation Training on Pain and Functional Disability in Children Diagnosed With Eosinophilic Duodenitis: Pilot Study Completed NCT00124501
10 Montelukast in the Treatment of Duodenal Eosinophilia in Children With Dyspepsia: Effect on Eosinophil Density and Activation in Relation to Pharmacokinetics Completed NCT00148603 montelukast
11 The Effect of Esomeprazole on Gastrin Levels and Glycaemic Regulation of Type 2 Diabetes: A Prospective Trial Completed NCT03598738 Esomeprazole 40mg
12 A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Crohn's Disease Recruiting NCT04100005
13 Interobserver Agreement of Endoscopic Diagnosis of Helicobacter Pylori Based on the Arrangement of Gastric Collecting Venules: Prospective and Multicenter Study Recruiting NCT04000243
14 Pattern of Upper Gastrointestinal Lesions in Upper Egypt : Clinical, Endoscopic and Pathological Evaluation Not yet recruiting NCT04328324
15 Impact of Treatment With Protonic Pump Inhibitors After Laparoscopic Sleeve Gastrectomy on Gastro-esophageal Reflux Disease Symptoms: Pilot Study Not yet recruiting NCT04400136 Early Phase 1 Lansoprazole oral tablets 30 mg

Search NIH Clinical Center for Duodenitis

Cochrane evidence based reviews: duodenitis

Genetic Tests for Duodenitis

Anatomical Context for Duodenitis

MalaCards organs/tissues related to Duodenitis:

40
Testes, Liver, Colon, Small Intestine, Heart, Pancreas, T Cells

Publications for Duodenitis

Articles related to Duodenitis:

(show top 50) (show all 1468)
# Title Authors PMID Year
1
[Analysis of the importance of Helicobacter pylori strains in children with gastric and duodenal mucosal inflammatory changes]. 61 54
16733275 2005
2
Consensus and variable region PCR analysis of Helicobacter pylori 3' region of cagA gene in isolates from individuals with or without peptic ulcer. 54 61
11158115 2001
3
A rare case of multiple carcinoids and endocrine cell micronests in a patient with chronic duodenitis. 61 54
10964325 2000
4
Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers. 54 61
9922305 1999
5
[On the pathogenesis and treatment of erosive gastritis and duodenitis]. 61 54
10380457 1999
6
[Helicobacter pylori CagA antigen antibodies]. 54 61
9748734 1998
7
Does CagA contribute to ulcer pathogenesis in a developing country, such as Sudan? 54 61
9855047 1998
8
The effects of hemodialysis on duodenal and gastric mucosal changes in uremic patients. 61 54
8738662 1996
9
An extremely rare case of nivolumab-associated macroscopic duodenitis with spontaneous regression. 61
32405415 2020
10
Immunosuppression-induced clonal T-cell lymphoproliferative disease causing severe diarrhoea mimicking coeliac disease following renal transplantation: a case report. 61
32522162 2020
11
Correlation between intestinal health and coccidiosis prevalence in broilers in Brazilian agroindustries. 61
31756388 2020
12
Iron pill-induced duodenitis: A distinct pattern of duodenal mucosal injury in a patient with a duodenal mass. 61
32146003 2020
13
Nasogastric Intubation as Health and Safety Risk in Equine Practice-A Questionnaire. 61
32303319 2020
14
Analysis of Somatostatin-Secreting Gastric Delta Cells according to Upper Abdominal Symptoms and Helicobacter pylori Infection in Children. 61
32483545 2020
15
Pathologic Manifestations of Gastrointestinal and Hepatobiliary Injury in Immune Checkpoint Inhibitor Therapy. 61
32338534 2020
16
Duodenal tuberculosis; uncommon cause of gastric outlet obstruction. 61
31228078 2020
17
Focal duodenal necrosis in chickens: attempts to reproduce the disease experimentally and diagnostic considerations. 61
31983302 2020
18
Fatal intestinal inflammatory lesions in equids in California: 710 cases (1990-2013). 61
31999521 2020
19
The impact of allergic rhinitis on gastrointestinal disorders among young adults. 61
30773746 2020
20
Preoperative Endoscopic Findings in Veterans Undergoing Bariatric Surgery: Prevalence and Predictors of Barrett's Esophagus. 61
31713148 2020
21
Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy. 61
32307399 2020
22
Atypical Salmonellosis in a Horse: Implications for Hospital Safety. 61
32566354 2020
23
Risk of stomach cancer incidence in a cohort of Mayak PA workers occupationally exposed to ionizing radiation. 61
32294114 2020
24
A Complicated Entity: Acute Celiac Artery Dissection with Resultant Pancreatitis, Duodenitis, and Cholecystitis. 61
31984149 2020
25
Duodenal Ulceration in a Child with Coeliac Disease. 61
31936445 2020
26
Diagnostic value of fecal B cell activating factor in patients with abdominal discomfort. 61
31314927 2019
27
Clinical manifestations and gastrointestinal pathology in 40 patients with autoimmune enteropathy. 61
31279857 2019
28
Gastrointestinal findings in 26 adults with common variable immunodeficiency: The fickle nature of the disease manifests in gastrointestinal biopsies. 61
31530523 2019
29
Evaluation of upper gastrointestinal system in acromegaly. 61
31227172 2019
30
A case of checkpoint inhibitor-induced celiac disease. 61
31383006 2019
31
Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. 61
31232887 2019
32
Analysis of clinical and histopathological findings in Russell body gastritis and duodenitis. 61
31031217 2019
33
Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases-An endoscopy cross-sectional study. 61
31001924 2019
34
Regulatory T cells and IgE expression in duodenal mucosa of Strongyloides stercoralis and human T lymphotropic virus type 1 co-infected patients. 61
31170141 2019
35
CLL2-BIG: sequential treatment with bendamustine, ibrutinib and obinutuzumab (GA101) in chronic lymphocytic leukemia. 61
30568174 2019
36
Spectrum of Endoscopic Findings in Patients of Upper Gastrointestinal Bleeding at a Tertiary Care Hospital. 61
31281746 2019
37
Degranulated Eosinophils Contain More Fine Nerve Fibers in the Duodenal Mucosa of Patients With Functional Dyspepsia. 61
30827070 2019
38
Remission of diffuse ulcerative duodenitis in a patient with ulcerative colitis after infliximab therapy: a case study and review of the literature. 61
30739436 2019
39
Mortality rate and risk factors for gastrointestinal bleeding in elderly patients. 61
30522789 2019
40
Inpatient Outcomes for Gastrointestinal Bleeding Associated With Percutaneous Coronary Intervention. 61
29351155 2019
41
A pictorial essay of the most atypical variants of the vermiform appendix position in computed tomography with their possible clinical implications. 61
31019588 2019
42
Crushed dolutegravir/abacavir/lamivudine given via nasogastric tube in gastric outlet obstruction caused by cancer resulted in rapid viral load suppression. 61
30231834 2019
43
Efficacy and safety of Syferol-IHP for the treatment of peptic ulcer disease: a pilot, double-blind randomized trial. 61
30679917 2019
44
Application of PCR and Microscopy to Detect Helicobacter pylori in Gastric Biopsy Specimen among Acid Peptic Disorders at Tertiary Care Centre in Eastern Nepal. 61
30867850 2019
45
Clinical significance of upper gastrointestinal endoscopy before laparoscopic bariatric procedures in Japanese patients. 61
30167923 2019
46
Automated Detection of Celiac Disease on Duodenal Biopsy Slides: A Deep Learning Approach. 61
30984467 2019
47
Brunner's Gland Hyperplasias and Hamartomas in Association with Helicobacter pylori. 61
31187029 2019
48
Improvement in Clinical Symptoms and Fecal Microbiome After Fecal Microbiota Transplantation in a Dog with Inflammatory Bowel Disease. 61
31819862 2019
49
Patient Characteristics from an Emergency Care Center in Rural Western Kenya. 61
30527618 2019
50
Recurrent abdominal pain and upper gastrointestinal endoscopy findings in children and adolescents presenting at the Lagos University Teaching Hospital. 61
31120915 2019

Variations for Duodenitis

Expression for Duodenitis

Search GEO for disease gene expression data for Duodenitis.

Pathways for Duodenitis

Pathways related to Duodenitis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.46 TNF INS CD8A CD40LG CD4
2 12.31 TNF MALT1 CD8A CD40LG
3
Show member pathways
11.89 TNF INS CRP ALB
4 11.76 TNF CD8A CD4
5
Show member pathways
11.72 MALT1 CD8A CD4
6 11.67 TNF MALT1 CD40LG
7 11.64 TNF MALT1 CD4
8 11.6 TNF CD8A CD4
9
Show member pathways
11.56 TNF MALT1 CD8A CD40LG CD4
10 11.48 TNF CD8A CD4
11 11.41 TNF CD8A CD4
12 10.71 CD8A CD40LG CD4
13 9.85 GAST ATP4A

GO Terms for Duodenitis

Cellular components related to Duodenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TNF S100A8 INS GAST CRP CD8A
2 cell GO:0005623 9.63 TOR1A TGM2 S100A8 CD4 ATP4A ATP12A
3 endoplasmic reticulum lumen GO:0005788 9.26 TOR1A INS CD4 ALB
4 extracellular space GO:0005615 9.23 TNF S100A8 INS GAST CRP CD40LG

Biological processes related to Duodenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of inflammatory response GO:0050729 9.54 TNF TGM2 S100A8
2 sodium ion export across plasma membrane GO:0036376 9.46 ATP4A ATP12A
3 cellular potassium ion homeostasis GO:0030007 9.43 ATP4A ATP12A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.4 ATP4A ATP12A
5 negative regulation of blood vessel diameter GO:0097756 9.32 INS CRP
6 negative regulation of lipid storage GO:0010888 9.26 TNF CRP
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.26 TNF TGM2 MALT1 CD4
8 regulation of immunoglobulin secretion GO:0051023 9.16 TNF CD40LG
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.02 TNF S100A8 MALT1 INS CD40LG

Molecular functions related to Duodenitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.5 TNF MALT1 INS
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
3 identical protein binding GO:0042802 9.23 TOR1A TNF TGM2 MALT1 INS CRP
4 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
5 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A

Sources for Duodenitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....