MCID: DDN004
MIFTS: 34

Duodenogastric Reflux

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenogastric Reflux

MalaCards integrated aliases for Duodenogastric Reflux:

Name: Duodenogastric Reflux 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4071
MeSH 45 D004383
SNOMED-CT 69 9733003
UMLS 74 C0013299

Summaries for Duodenogastric Reflux

MalaCards based summary : Duodenogastric Reflux is related to peptic ulcer disease and dyspepsia. An important gene associated with Duodenogastric Reflux is NTS (Neurotensin), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Somatostatin and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include pancreas, colon and testes.

Related Diseases for Duodenogastric Reflux

Diseases related to Duodenogastric Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 peptic ulcer disease 30.9 GAST SCT
2 dyspepsia 30.3 CCK SST
3 atrophic gastritis 30.1 GAST SST
4 cholelithiasis 30.0 CCK SST
5 gastroparesis 30.0 CCK GAST MLN
6 duodenal ulcer 29.9 CCK GAST SCT SST
7 irritable bowel syndrome 29.6 CCK MLN PYY
8 dumping syndrome 29.5 NTS PYY SCT SST
9 postcholecystectomy syndrome 29.5 CCK GAST MLN SST
10 gastroesophageal reflux 29.5 CCK GAST MLN NTS PYY
11 duodenal atresia 11.4
12 gastritis 10.7
13 gastric ulcer 10.6
14 helicobacter pylori infection 10.4
15 esophagitis 10.4
16 degos 'en cocarde' erythrokeratoderma 10.4
17 gallbladder disease 1 10.2
18 barrett esophagus 10.2
19 peptic esophagitis 10.2
20 nasal cavity adenocarcinoma 10.2 CCK GAST
21 diphyllobothriasis 10.2 GAST SCT
22 cataract 14, multiple types 10.1 CCK GAST
23 pain agnosia 10.1 CCK NTS
24 agnosia 10.1 CCK NTS
25 biliary dyskinesia 10.1 CCK SCT
26 gastrointestinal neuroendocrine benign tumor 10.1 GAST SST
27 gastric neuroendocrine neoplasm 10.1 GAST SST
28 pancreatic steatorrhea 10.1 CCK SCT
29 retinitis pigmentosa 40 10.1 GAST SST
30 pernicious anemia 10.1 GAST SST
31 exocrine pancreatic insufficiency 10.1 CCK SCT
32 alcoholic pancreatitis 10.1 CCK SCT
33 mixed ductal-endocrine carcinoma 10.1 GAST SST
34 pancreatoblastoma 10.1 NTS SST
35 ileum cancer 10.1 GAST SST
36 hernia, hiatus 10.1
37 ige responsiveness, atopic 10.1
38 intussusception 10.1
39 bile duct cysts 10.1
40 chagas disease 10.1
41 cholecystitis 10.1
42 adenocarcinoma 10.1
43 islet cell tumor 10.1 GAST SST
44 gastrointestinal system benign neoplasm 10.1 GAST SST
45 insulinoma 10.1 SCT SST
46 maturity-onset diabetes of the young, type 7 10.0 CCK SCT
47 glucagonoma 10.0 SCT SST
48 angiodysplasia 10.0 SCT SST
49 functional colonic disease 10.0 MLN SST
50 rasmussen encephalitis 10.0 CCK SST

Graphical network of the top 20 diseases related to Duodenogastric Reflux:



Diseases related to Duodenogastric Reflux

Symptoms & Phenotypes for Duodenogastric Reflux

Drugs & Therapeutics for Duodenogastric Reflux

Drugs for Duodenogastric Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
2
lanreotide Approved Phase 2 108736-35-2
3 Hormones Phase 2
4 Angiopeptin Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
6 Hormone Antagonists Phase 2
7 Neurotransmitter Agents Phase 2
8 Z 338 Phase 2
9 Gastrointestinal Agents Phase 2,Not Applicable
10 Cholinesterase Inhibitors Phase 2
11 Cholinergic Agents Phase 2
12
Omeprazole Approved, Investigational, Vet_approved Not Applicable 73590-58-6 4594
13 Antacids Not Applicable
14 Anti-Ulcer Agents Not Applicable
15 Proton Pump Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
2 Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy Unknown status NCT02054637 Phase 2 Lanreotide
3 The Effect of Z-338 in Subjects With Functional Dyspepsia Completed NCT00458328 Phase 2 Z-338
4 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831
5 Laparoscopic Total Fundoplication for Duodenogastroesophageal Reflux Completed NCT01741441
6 Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease Completed NCT02685150 Not Applicable Omeprazole
7 Omega Loop Gastric Bypass With And Without Anti-Reflux Sutures Recruiting NCT03097887 Not Applicable

Search NIH Clinical Center for Duodenogastric Reflux

Cochrane evidence based reviews: duodenogastric reflux

Genetic Tests for Duodenogastric Reflux

Anatomical Context for Duodenogastric Reflux

MalaCards organs/tissues related to Duodenogastric Reflux:

42
Pancreas, Colon, Testes, Eye, Lung, Thyroid, Small Intestine

Publications for Duodenogastric Reflux

Articles related to Duodenogastric Reflux:

(show top 50) (show all 269)
# Title Authors Year
1
Durable Flap-Valve Mitigation of Duodenogastric Reflux,  Remnant Gastritis and Dumping Syndrome Following Billroth I Reconstruction. ( 26666548 )
2016
2
Influence of duodenogastric reflux in the gastric mucosa histological changes of rats infected with Helicobacter pylori. ( 27679942 )
2016
3
Cholecystectomy and duodenogastric reflux: interacting effects over the gastric mucosa. ( 27917345 )
2016
4
Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux. ( 26527935 )
2013
5
Comparative evaluation of intragastric bile acids and hepatobiliary scintigraphy in the diagnosis of duodenogastric reflux. ( 23599645 )
2013
6
Late administration of a specific COX-2 inhibitor does not treat and/or prevent progression of gastric tumors in rats submitted to duodenogastric reflux procedure. ( 23743684 )
2013
7
A flow visualization model of duodenogastric reflux after esophagectomy with gastric interposition. ( 24067071 )
2013
8
The role of duodenogastric reflux in formation of precarcinogenic gastric lesions--an experimental study. ( 24069809 )
2013
9
Intrathoracic gastric activity on cholescintigraphy results in a large hiatus hernia with duodenogastric reflux. ( 20395721 )
2010
10
A selective cyclooxygenase-2 inhibitor prevents inflammation-related squamous cell carcinogenesis of the forestomach via duodenogastric reflux in rats. ( 19110997 )
2009
11
Duodenogastric reflux induced by endoscopic submucosal dissection. ( 19866392 )
2009
12
Effect of Roux-en-Y gastric bypass in obese patients with Barrett's esophagus: attempts to eliminate duodenogastric reflux. ( 18069070 )
2008
13
A report on associations among gastric pH, bleeding, duodenogastric reflux, and outcomes after trauma. ( 18188106 )
2008
14
Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux. ( 18640116 )
2008
15
Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor. ( 18646190 )
2008
16
Prevalence of pathological duodenogastric reflux and the relationship between duodenogastric and duodenogastrooesophageal reflux in chronic gastrooesophageal reflux disease. ( 18946360 )
2008
17
Duodenal switch operation for pathologic transpyloric duodenogastric reflux. ( 17245178 )
2007
18
Does troncular vagotomy modify the proliferative gastric lesions induced in rats by duodenogastric reflux? ( 17546294 )
2007
19
Duodenogastric reflux after choledochoduodenostomy: evaluation by technetium-99m scintigraphy. ( 17591065 )
2007
20
Duodenogastric reflux in a hiatal hernia seen as retrocardiac activity on 99mTc-tetrofosmin cardiac SPECT raw-data images. ( 18006595 )
2007
21
Laparoscopic duodenal switch for pathologic duodenogastric reflux: initial experience. ( 18097313 )
2007
22
Gastric proliferative lesions induced by duodenogastric reflux in rats. ( 16862339 )
2006
23
Importance of duodenogastric reflux in gastro-oesophageal reflux disease. ( 17051600 )
2006
24
Duodenogastric reflux shown on raw data images on dual-isotope gated cardiac Tc-99m tetrofosmin SPECT in a patient with esophagectomy for Barrett esophagus. ( 15604966 )
2005
25
Duodenogastric reflux following biliary reconstruction after excision of choledochal cyst. ( 15480709 )
2005
26
Duodenogastric reflux after esophagectomy and gastric pull-up: the effect of the route of reconstruction. ( 15650801 )
2005
27
Duodenogastric Reflux-induced (Alkaline) Esophagitis. ( 14723838 )
2004
28
Lanzoprazole promotes gastric carcinogenesis in rats with duodenogastric reflux. ( 15052437 )
2004
29
Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils. ( 15069533 )
2004
30
Correlation between duodenogastric reflux and remnant gastritis after distal gastrectomy. ( 15239287 )
2004
31
Effects of duodenogastric reflux on gastrin cells, somatostatin cells and serotonin cells in human antral gastric mucosa. ( 15310146 )
2004
32
Duodenogastric reflux eradicates Helicobacter pylori after distal gastrectomy. ( 15362798 )
2004
33
Quantitative determinations of duodenogastric reflux, prevalence of Helicobacter pylori infection, and concentrations of interleukin-8. ( 12715225 )
2003
34
Duodenogastric reflux and Helicobacter pylori infection synergistically increase gastric mucosal cell proliferative activity in Mongolian gerbils. ( 12739708 )
2003
35
Cholecystectomy and duodenogastric reflux. ( 12801324 )
2003
36
Duodenogastric reflux after biliary surgery: scintigraphic quantification and improvement with erythromycin. ( 12801337 )
2003
37
Duodenogastric reflux and Helicobacter pylori infection in children. ( 12818297 )
2003
38
Primary duodenogastric reflux in children and adolescents. ( 12836018 )
2003
39
Duodenogastric reflux sustains Helicobacter pylori infection in the gastric stump. ( 14531528 )
2003
40
The effect of duodenogastric reflux on Helicobacter pylori presence and gastric histopathologic changes. ( 15048598 )
2003
41
Assessment of duodenogastric reflux by combined continuous intragastric pH and bilirubin monitoring. ( 11925631 )
2002
42
Duodenogastric reflux and gastric stump carcinoma. ( 12021855 )
2002
43
Duodenogastric reflux increases the penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine into the antral mucosa of rats: a possible role for mucosal erosions and increased cell proliferation in gastric carcinogenesis. ( 12036443 )
2002
44
Gastric mucosa lesions induced by duodenogastric reflux increase penetration of N-[3H]-methyl-N-nitro-N-nitrosoguanidine into corpus mucosa of rats. ( 12395909 )
2002
45
Ulceration as a possible link between duodenogastric reflux and neoplasms in the stomach of rats. ( 12429172 )
2002
46
Gastric bilirubin monitoring to assess duodenogastric reflux. ( 12498300 )
2002
47
Duodenogastric reflux is associated with antral metaplastic gastritis. ( 11154489 )
2001
48
The extent of duodenogastric reflux in gastro-oesophageal reflux disease. ( 11204810 )
2001
49
Reproducibility and intragastric variation of duodenogastric reflux using ambulatory gastric bilirubin monitoring. ( 11270798 )
2001
50
Hepatobiliary scintigraphy to detect duodenogastric reflux: intravenous administration of Tc-99m pertechnetate to define the location of the stomach. ( 11290908 )
2001

Variations for Duodenogastric Reflux

Expression for Duodenogastric Reflux

Search GEO for disease gene expression data for Duodenogastric Reflux.

Pathways for Duodenogastric Reflux

GO Terms for Duodenogastric Reflux

Cellular components related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CCK GAST PYY SCT SST
2 extracellular region GO:0005576 9.17 CCK GAST MLN NTS PYY SCT

Biological processes related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.5 CCK GAST MLN NTS PYY SCT
2 regulation of signaling receptor activity GO:0010469 9.17 CCK GAST MLN NTS PYY SCT
3 digestion GO:0007586 9.16 CCK SST

Molecular functions related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.16 PYY SCT
2 neuropeptide hormone activity GO:0005184 9.13 CCK NTS PYY
3 hormone activity GO:0005179 9.1 CCK GAST MLN PYY SCT SST

Sources for Duodenogastric Reflux

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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