MCID: DDN004
MIFTS: 31

Duodenogastric Reflux

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenogastric Reflux

MalaCards integrated aliases for Duodenogastric Reflux:

Name: Duodenogastric Reflux 12 54 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4071
MeSH 44 D004383
SNOMED-CT 67 9733003
UMLS 70 C0013299

Summaries for Duodenogastric Reflux

MalaCards based summary : Duodenogastric Reflux is related to gastric ulcer and gastritis. An important gene associated with Duodenogastric Reflux is GAST (Gastrin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Salivary secretion. Affiliated tissues include thyroid, pancreas and appendix.

Related Diseases for Duodenogastric Reflux

Diseases related to Duodenogastric Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 gastric ulcer 31.1 SST GAST
2 gastritis 30.9 SST SCT GAST ATP4A
3 postcholecystectomy syndrome 30.7 MLN GAST CCK
4 cholelithiasis 30.6 SST GAST CCK
5 duodenal ulcer 30.6 SST SCT MLN GAST CCK
6 barrett esophagus 30.3 GAST ATP4A ATP12A
7 cholecystolithiasis 30.2 SST CCK
8 peptic esophagitis 30.0 MLN GAST ATP4A ATP12A
9 irritable bowel syndrome 30.0 SST PYY MLN CCK
10 peptic ulcer disease 30.0 SST SCT GAST ATP4A ATP12A
11 gastrointestinal system disease 29.9 MLN GAST CCK
12 acute pancreatitis 29.9 SST SCT CCK
13 bile reflux 29.9 SCT MLN GAST CCK ATP4A ATP12A
14 afferent loop syndrome 29.8 ATP4A ATP12A
15 duodenitis 29.6 GAST CCK ATP4A ATP12A
16 gastroparesis 29.5 SST SCT MLN GAST CCK
17 hernia, hiatus 29.3 MLN GAST ATP4A ATP12A
18 gastroesophageal reflux 29.3 PYY NTS MLN GAST CCK ATP4A
19 dumping syndrome 29.2 SST SCT PYY NTS MLN GAST
20 duodenum disease 28.9 SST SCT GAST ATP4A ATP12A
21 biliary dyskinesia 28.8 SST SCT CCK ATP4A ATP12A
22 constipation 28.0 SST PYY NTS MLN GAST CCK
23 duodenal atresia 11.2
24 esophagitis 10.6
25 helicobacter pylori infection 10.5
26 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.5
27 atrophic gastritis 10.5
28 gallbladder disease 1 10.5
29 cholecystitis 10.3
30 neurogenic bowel 10.3 MLN GAST
31 opisthorchiasis 10.3
32 gastrointestinal neuroendocrine benign tumor 10.2 SST GAST
33 diabetic autonomic neuropathy 10.2 MLN GAST
34 non-functioning pancreatic endocrine tumor 10.2 SST GAST
35 rectum neuroendocrine neoplasm 10.2 SST GAST
36 nasal cavity adenocarcinoma 10.2 GAST CCK
37 gastric neuroendocrine neoplasm 10.2 SST GAST
38 appendix lymphoma 10.2 SST GAST
39 pancreatic steatorrhea 10.2 SCT CCK
40 functional colonic disease 10.2 SST MLN
41 duodenal somatostatinoma 10.2 SST GAST
42 somatostatinoma 10.2 SST GAST
43 gastrointestinal neuroendocrine tumor 10.2 SST GAST
44 carcinoid tumors, intestinal 10.2 SST GAST
45 colonic pseudo-obstruction 10.2 SST MLN
46 colon neuroendocrine neoplasm 10.2 SST GAST
47 functionless pituitary adenoma 10.2 SST CCK
48 enterokinase deficiency 10.2 SCT CCK
49 pancreatic endocrine carcinoma 10.2 SST GAST
50 endometrial small cell carcinoma 10.2 PYY GAST

Graphical network of the top 20 diseases related to Duodenogastric Reflux:



Diseases related to Duodenogastric Reflux

Symptoms & Phenotypes for Duodenogastric Reflux

Drugs & Therapeutics for Duodenogastric Reflux

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Prognostic Factors for Long Term Results of Total Laparoscopic Fundoplication for Weakly Acidic or Mixed Reflux Completed NCT01741441

Search NIH Clinical Center for Duodenogastric Reflux

Cochrane evidence based reviews: duodenogastric reflux

Genetic Tests for Duodenogastric Reflux

Anatomical Context for Duodenogastric Reflux

MalaCards organs/tissues related to Duodenogastric Reflux:

40
Thyroid, Pancreas, Appendix, Eye, Smooth Muscle, Small Intestine, Colon

Publications for Duodenogastric Reflux

Articles related to Duodenogastric Reflux:

(show top 50) (show all 842)
# Title Authors PMID Year
1
Effects of duodenogastric reflux on gastrin cells, somatostatin cells and serotonin cells in human antral gastric mucosa. 61 54
15310146 2004
2
Abnormal plasma gut hormones in pathologic duodenogastric reflux and their response to surgery. 54 61
8418694 1993
3
Duodenogastric reflux of bile acids, gastrin and parietal cells, and gastric acid secretion before and 6 months after cholecystectomy. 61 54
2349983 1990
4
Meta-Analysis Reveals the Prognostic Relevance of Nuclear and Membrane-Associated Bile Acid Receptors in Gastric Cancer. 61
33492921 2021
5
Theoretical modeling of the resistance to gastric emptying and duodenogastric reflux due to pyloric motility alone, presuming antral and duodenal quiescence. 61
32891592 2021
6
Development and characterization of a mouse model of duodenogastric reflux. 61
32926924 2020
7
Columnar epithelium morphology after esophagectomy: clinical insight into the development of Barrett's esophagus. 61
32383128 2020
8
Effect of Duodenogastric Reflux on Dental Enamel. 61
32895652 2020
9
Robotic Excision of Choledochal Cyst with Hepaticoduodenostomy (HD): Report of HD Technique, Initial Experience, and Early Outcome. 61
32668486 2020
10
An Unfortunate Consequence of Duodenogastric Reflux. 61
31404534 2020
11
Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect? 61
33027361 2020
12
Clinical, Endoscopic, and Histologic Findings at the Distal Esophagus and Stomach Before and Late (10.5 Years) After Laparoscopic Sleeve Gastrectomy: Results of a Prospective Study with 93% Follow-Up. 61
31583514 2019
13
The Effect of Primary Duodenogastric Bile Reflux on the Presence and Density of Helicobacter pylori and on Gastritis in Childhood. 61
31817518 2019
14
Prevalence of Helicobacter pylori is still high among symptomatic Bulgarian children. 61
30585499 2019
15
Late esophagogastric anatomic and functional changes after sleeve gastrectomy and its clinical consequences with regards to gastroesophageal reflux disease. 61
31076757 2019
16
PECULIARITIES OF ACID PRODUCTION AND PATHOGENESIS OF PYLORIC AND PREPYLORIC GASTRIC ULCER COMPLICATIONS. 61
31418722 2019
17
[CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF THE GASTRODUODENAL MUCOSAL LESIONS IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION WITH DIFFERENT BODY MASS STATUS]. 61
31101780 2019
18
Twenty-four-hour oesophageal pH studies in rural Eastern Cape Province, South Africa. 61
30645964 2018
19
[Progress and controversy on diagnosis and treatment of gastric stump cancer]. 61
29774942 2018
20
Non-Helicobacter pylori Gastric Intestinal Metaplasia in Children: A Series of Cases and Review of the Literature. 61
29850294 2018
21
Oxidative stress from reflux esophagitis to esophageal cancer: the alleviation with antioxidants. 61
27109388 2016
22
Influence of duodenogastric reflux in the gastric mucosa histological changes of rats infected with Helicobacter pylori. 61
27679942 2016
23
Durable Flap-Valve Mitigation of Duodenogastric Reflux,  Remnant Gastritis and Dumping Syndrome Following Billroth I Reconstruction. 61
26666548 2016
24
Considerations on risk factors correlated to the occurrence of gastric stump cancer. 61
27453741 2016
25
Current status in remnant gastric cancer after distal gastrectomy. 61
26937131 2016
26
[Biliary reflux-gastritis: etiology, pathogenesis and modern principles of treatment]. 61
30289664 2016
27
Deoxycholic Acid Could Induce Apoptosis and Trigger Gastric Carcinogenesis on Gastric Epithelial Cells by Quantitative Proteomic Analysis. 61
28070185 2016
28
Cholecystectomy and duodenogastric reflux: interacting effects over the gastric mucosa. 61
27917345 2016
29
[MECHANISMS OF GASTRODUODENAL DYSMOTILITY UNDER STRESS]. 61
27301116 2016
30
[Diagnosis of sphincter of Oddi dysfunction in patients with postcholecystectomy syndrome from hepatobiliary scintigraphic findings]. 61
26999929 2015
31
Heterotopic Gastric Mucosa in the Distal Part of Esophagus in a Teenager: Case Report. 61
26496283 2015
32
Common Mechanism of Pathogenesis in Gastrointestinal Diseases Implied by Consistent Efficacy of Single Chinese Medicine Formula: A PRISMA-Compliant Systematic Review and Meta-Analysis. 61
26166106 2015
33
Pepsin and bile acids in saliva in patients with laryngopharyngeal reflux - a prospective comparative study. 61
25516364 2015
34
[DISSEMINATION BY H. PYLORI IN PATIENTS, SUFFERING VARIOUS FORMS OF CHOLECYSTITIS]. 61
26419024 2015
35
Defective upper gastrointestinal function after repair of combined esophageal and duodenal atresia. 61
25840057 2015
36
24-Hour Measurement of Gastric pH in Rural South Africa. 61
25861260 2015
37
Current status of function-preserving surgery for gastric cancer. 61
25516640 2014
38
Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD. 61
25232231 2014
39
Peculiarities of gastrointestinal disease concomitant to heart connective tissue dysplasia in children born from persons exposed to ionizing radiation in childhood after the ChNPP accident. 61
25536566 2014
40
LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3. 61
24674670 2014
41
Automatic motion analysis system for pyloric flow in ultrasonic videos. 61
24403410 2014
42
[Indications for surgical treatment of hard scarring gastric ulcers]. 61
24781063 2014
43
[Gastroesophageal reflux disease associated with duodenogastroesophageal reflux in patients with biliary pathology: the specific features of the course and esophagogastroduodenal microbial biocenosis]. 61
24772502 2014
44
Elevated serum dopamine increases while coffee consumption decreases the occurrence of reddish streaks in the intact stomach. 61
23800237 2013
45
Operatively induced chronic reflux in rats: a suitable model for studying esophageal carcinogenesis? 61
24084597 2013
46
A flow visualization model of duodenogastric reflux after esophagectomy with gastric interposition. 61
24067071 2013
47
The role of duodenogastric reflux in formation of precarcinogenic gastric lesions--an experimental study. 61
24069809 2013
48
Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer. 61
23673508 2013
49
Late administration of a specific COX-2 inhibitor does not treat and/or prevent progression of gastric tumors in rats submitted to duodenogastric reflux procedure. 61
23743684 2013
50
Weighted cross-correlation based variational optical flow for gastric flow analysis in ultrasonic videos. 61
23635294 2013

Variations for Duodenogastric Reflux

Expression for Duodenogastric Reflux

Search GEO for disease gene expression data for Duodenogastric Reflux.

Pathways for Duodenogastric Reflux

GO Terms for Duodenogastric Reflux

Cellular components related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 SST SCT PYY GAST CCK ATP4A
2 extracellular region GO:0005576 9.17 SST SCT PYY NTS MLN GAST

Biological processes related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.4 ATP4A ATP12A
2 digestion GO:0007586 9.37 SST CCK
3 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.26 ATP4A ATP12A
5 G protein-coupled receptor signaling pathway GO:0007186 9.17 SST SCT PYY NTS MLN GAST
6 cellular potassium ion homeostasis GO:0030007 9.16 ATP4A ATP12A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.96 ATP4A ATP12A

Molecular functions related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 9.26 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 9.16 ATP4A ATP12A
4 neuropeptide hormone activity GO:0005184 9.13 PYY NTS CCK
5 hormone activity GO:0005179 9.1 CCK GAST MLN PYY SCT SST

Sources for Duodenogastric Reflux

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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