MCID: DDN004
MIFTS: 33

Duodenogastric Reflux

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenogastric Reflux

MalaCards integrated aliases for Duodenogastric Reflux:

Name: Duodenogastric Reflux 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4071
MeSH 44 D004383
SNOMED-CT 68 9733003
UMLS 73 C0013299

Summaries for Duodenogastric Reflux

MalaCards based summary : Duodenogastric Reflux is related to peptic ulcer disease and biliary dyskinesia. An important gene associated with Duodenogastric Reflux is NTS (Neurotensin), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Menthol and lanreotide have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and eye.

Related Diseases for Duodenogastric Reflux

Diseases related to Duodenogastric Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 peptic ulcer disease 30.8 GAST SCT
2 biliary dyskinesia 30.2 CCK SCT
3 dyspepsia 30.0 CCK SST
4 atrophic gastritis 29.8 GAST SST
5 cholelithiasis 29.7 CCK SST
6 irritable bowel syndrome 29.7 CCK MLN
7 pancreatitis 29.6 CCK SCT SST
8 gastroparesis 29.6 CCK GAST MLN
9 duodenal ulcer 29.0 CCK GAST SCT SST
10 postcholecystectomy syndrome 28.6 CCK GAST MLN SST
11 gastroesophageal reflux 28.0 CCK GAST MLN NTS PYY
12 dumping syndrome 27.9 NTS PYY SCT SST
13 duodenal atresia 11.2
14 gastritis 10.5
15 duodenitis 10.5
16 nasal cavity adenocarcinoma 10.4 CCK GAST
17 mucositis 10.4
18 gastric ulcer 10.4
19 esophagitis 10.3
20 diphyllobothriasis 10.3 GAST SCT
21 helicobacter pylori infection 10.3
22 cataract 14, multiple types 10.3 CCK GAST
23 pain agnosia 10.3 CCK NTS
24 gastrointestinal neuroendocrine benign tumor 10.3 GAST SST
25 duodenal disease 10.2 CCK SCT
26 agnosia 10.2 CCK NTS
27 gastric neuroendocrine neoplasm 10.2 GAST SST
28 pancreatic steatorrhea 10.2 CCK SCT
29 retinitis pigmentosa 40 10.2 GAST SST
30 pernicious anemia 10.2 GAST SST
31 exocrine pancreatic insufficiency 10.2 CCK SCT
32 mixed ductal-endocrine carcinoma 10.2 GAST SST
33 pancreatoblastoma 10.2 NTS SST
34 alcoholic pancreatitis 10.2 CCK SCT
35 islet cell tumor 10.2 GAST SST
36 pancreatic gastrinoma 10.1 SCT SST
37 glucagonoma 10.0 SCT SST
38 gastroduodenitis 10.0
39 angiodysplasia 10.0 SCT SST
40 rasmussen encephalitis 10.0 CCK SST
41 functional colonic disease 10.0 MLN SST
42 colonic pseudo-obstruction 10.0 MLN SST
43 hernia, hiatus 9.9
44 ige responsiveness, atopic 9.9
45 intussusception 9.9
46 bile duct cysts 9.9
47 barrett esophagus 9.9
48 chagas disease 9.9
49 cholecystitis 9.9
50 adenocarcinoma 9.9

Graphical network of the top 20 diseases related to Duodenogastric Reflux:



Diseases related to Duodenogastric Reflux

Symptoms & Phenotypes for Duodenogastric Reflux

Drugs & Therapeutics for Duodenogastric Reflux

Drugs for Duodenogastric Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 3,Not Applicable 2216-51-5 16666
2 lanreotide Approved Phase 2 108736-35-2
3
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
4 Angiopeptin Phase 2
5 Hormone Antagonists Phase 2
6 Hormones Phase 2
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
8
Omeprazole Approved, Investigational, Vet_approved Not Applicable 73590-58-6 4594
9 Antacids Not Applicable
10 Anti-Ulcer Agents Not Applicable
11 Gastrointestinal Agents Not Applicable
12 Proton Pump Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy Withdrawn NCT00622804 Phase 3
2 Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy Unknown status NCT02054637 Phase 2 Lanreotide
3 The Effect of Z-338 in Subjects With Functional Dyspepsia Completed NCT00458328 Phase 2 Z-338
4 The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy Unknown status NCT00441831
5 Laparoscopic Total Fundoplication for Duodenogastroesophageal Reflux Completed NCT01741441
6 Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease Recruiting NCT02685150 Not Applicable Omeprazole
7 Omega Loop Gastric Bypass With And Without Anti-Reflux Sutures Not yet recruiting NCT03097887 Not Applicable

Search NIH Clinical Center for Duodenogastric Reflux

Cochrane evidence based reviews: duodenogastric reflux

Genetic Tests for Duodenogastric Reflux

Anatomical Context for Duodenogastric Reflux

MalaCards organs/tissues related to Duodenogastric Reflux:

41
Testes, Pancreas, Eye

Publications for Duodenogastric Reflux

Articles related to Duodenogastric Reflux:

(show top 50) (show all 266)
# Title Authors Year
1
Durable Flap-Valve Mitigation of Duodenogastric Reflux, A Remnant GastritisA and Dumping Syndrome Following Billroth I Reconstruction. ( 26666548 )
2016
2
Influence of duodenogastric reflux in the gastric mucosa histological changes of rats infected with Helicobacter pylori. ( 27679942 )
2016
3
Cholecystectomy and duodenogastric reflux: interacting effects over the gastric mucosa. ( 27917345 )
2016
4
A flow visualization model of duodenogastric reflux after esophagectomy with gastric interposition. ( 24067071 )
2013
5
Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux. ( 26527935 )
2013
6
Late administration of a specific COX-2 inhibitor does not treat and/or prevent progression of gastric tumors in rats submitted to duodenogastric reflux procedure. ( 23743684 )
2013
7
The role of duodenogastric reflux in formation of precarcinogenic gastric lesions--an experimental study. ( 24069809 )
2013
8
Comparative evaluation of intragastric bile acids and hepatobiliary scintigraphy in the diagnosis of duodenogastric reflux. ( 23599645 )
2013
9
[Duodenogastral reflux burden gastroesophageal reflux disease]. ( 22629750 )
2011
10
Intrathoracic gastric activity on cholescintigraphy results in a large hiatus hernia with duodenogastric reflux. ( 20395721 )
2010
11
A selective cyclooxygenase-2 inhibitor prevents inflammation-related squamous cell carcinogenesis of the forestomach via duodenogastric reflux in rats. ( 19110997 )
2009
12
Duodenogastric reflux induced by endoscopic submucosal dissection. ( 19866392 )
2009
13
Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux. ( 18640116 )
2008
14
Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor. ( 18646190 )
2008
15
Prevalence of pathological duodenogastric reflux and the relationship between duodenogastric and duodenogastrooesophageal reflux in chronic gastrooesophageal reflux disease. ( 18946360 )
2008
16
A report on associations among gastric pH, bleeding, duodenogastric reflux, and outcomes after trauma. ( 18188106 )
2008
17
Effect of Roux-en-Y gastric bypass in obese patients with Barrett's esophagus: attempts to eliminate duodenogastric reflux. ( 18069070 )
2008
18
Duodenogastric reflux in a hiatal hernia seen as retrocardiac activity on 99mTc-tetrofosmin cardiac SPECT raw-data images. ( 18006595 )
2007
19
Duodenogastric reflux after choledochoduodenostomy: evaluation by technetium-99m scintigraphy. ( 17591065 )
2007
20
Does troncular vagotomy modify the proliferative gastric lesions induced in rats by duodenogastric reflux? ( 17546294 )
2007
21
Laparoscopic duodenal switch for pathologic duodenogastric reflux: initial experience. ( 18097313 )
2007
22
Duodenal switch operation for pathologic transpyloric duodenogastric reflux. ( 17245178 )
2007
23
Importance of duodenogastric reflux in gastro-oesophageal reflux disease. ( 17051600 )
2006
24
Gastric proliferative lesions induced by duodenogastric reflux in rats. ( 16862339 )
2006
25
Duodenogastric reflux following biliary reconstruction after excision of choledochal cyst. ( 15480709 )
2005
26
Duodenogastric reflux after esophagectomy and gastric pull-up: the effect of the route of reconstruction. ( 15650801 )
2005
27
Duodenogastric reflux shown on raw data images on dual-isotope gated cardiac Tc-99m tetrofosmin SPECT in a patient with esophagectomy for Barrett esophagus. ( 15604966 )
2005
28
Effects of duodenogastric reflux on gastrin cells, somatostatin cells and serotonin cells in human antral gastric mucosa. ( 15310146 )
2004
29
Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils. ( 15069533 )
2004
30
Duodenogastric reflux eradicates Helicobacter pylori after distal gastrectomy. ( 15362798 )
2004
31
Duodenogastric Reflux-induced (Alkaline) Esophagitis. ( 14723838 )
2004
32
Correlation between duodenogastric reflux and remnant gastritis after distal gastrectomy. ( 15239287 )
2004
33
Lanzoprazole promotes gastric carcinogenesis in rats with duodenogastric reflux. ( 15052437 )
2004
34
Duodenogastric reflux and Helicobacter pylori infection synergistically increase gastric mucosal cell proliferative activity in Mongolian gerbils. ( 12739708 )
2003
35
Cholecystectomy and duodenogastric reflux. ( 12801324 )
2003
36
Primary duodenogastric reflux in children and adolescents. ( 12836018 )
2003
37
Quantitative determinations of duodenogastric reflux, prevalence of Helicobacter pylori infection, and concentrations of interleukin-8. ( 12715225 )
2003
38
Duodenogastric reflux and Helicobacter pylori infection in children. ( 12818297 )
2003
39
Duodenogastric reflux sustains Helicobacter pylori infection in the gastric stump. ( 14531528 )
2003
40
The effect of duodenogastric reflux on Helicobacter pylori presence and gastric histopathologic changes. ( 15048598 )
2003
41
Duodenogastric reflux after biliary surgery: scintigraphic quantification and improvement with erythromycin. ( 12801337 )
2003
42
Assessment of duodenogastric reflux by combined continuous intragastric pH and bilirubin monitoring. ( 11925631 )
2002
43
Gastric bilirubin monitoring to assess duodenogastric reflux. ( 12498300 )
2002
44
Gastric mucosa lesions induced by duodenogastric reflux increase penetration of N-[3H]-methyl-N-nitro-N-nitrosoguanidine into corpus mucosa of rats. ( 12395909 )
2002
45
Duodenogastric reflux increases the penetration of N-3H-methyl-N-nitro-N-nitrosoguanidine into the antral mucosa of rats: a possible role for mucosal erosions and increased cell proliferation in gastric carcinogenesis. ( 12036443 )
2002
46
Duodenogastric reflux and gastric stump carcinoma. ( 12021855 )
2002
47
Ulceration as a possible link between duodenogastric reflux and neoplasms in the stomach of rats. ( 12429172 )
2002
48
Reproducibility and intragastric variation of duodenogastric reflux using ambulatory gastric bilirubin monitoring. ( 11270798 )
2001
49
Duodenogastric reflux on (99m)Tc-tetrofosmin myocardial SPECT mimics left ventricle inferior wall reverse redistribution and falsely decreases ejection fraction: a case report. ( 11756531 )
2001
50
Hepatobiliary scintigraphy to detect duodenogastric reflux: intravenous administration of Tc-99m pertechnetate to define the location of the stomach. ( 11290908 )
2001

Variations for Duodenogastric Reflux

Expression for Duodenogastric Reflux

Search GEO for disease gene expression data for Duodenogastric Reflux.

Pathways for Duodenogastric Reflux

GO Terms for Duodenogastric Reflux

Cellular components related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CCK GAST PYY SCT SST
2 extracellular region GO:0005576 9.17 CCK GAST MLN NTS PYY SCT

Biological processes related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.5 CCK GAST MLN NTS PYY SCT
2 regulation of signaling receptor activity GO:0010469 9.17 CCK GAST MLN NTS PYY SCT

Molecular functions related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor binding GO:0001664 9.16 PYY SCT
2 neuropeptide hormone activity GO:0005184 9.13 CCK NTS PYY
3 hormone activity GO:0005179 9.1 CCK GAST MLN PYY SCT SST

Sources for Duodenogastric Reflux

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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