MCID: DDN004
MIFTS: 33

Duodenogastric Reflux

Categories: Gastrointestinal diseases

Aliases & Classifications for Duodenogastric Reflux

MalaCards integrated aliases for Duodenogastric Reflux:

Name: Duodenogastric Reflux 12 54 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4071
MeSH 43 D004383
SNOMED-CT 67 9733003
UMLS 71 C0013299

Summaries for Duodenogastric Reflux

MalaCards based summary : Duodenogastric Reflux is related to postcholecystectomy syndrome and cholelithiasis. An important gene associated with Duodenogastric Reflux is GAST (Gastrin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Salivary secretion. Affiliated tissues include liver, testes and eye, and related phenotype is homeostasis/metabolism.

Related Diseases for Duodenogastric Reflux

Diseases related to Duodenogastric Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 postcholecystectomy syndrome 30.9 MLN GAST CCK
2 cholelithiasis 30.8 SST GAST CCK
3 gastritis 30.8 SST SCT GAST ATP4A
4 duodenal ulcer 30.7 SST SCT MLN GAST CCK
5 cholecystolithiasis 30.5 SST CCK
6 irritable bowel syndrome 30.1 SST PYY MLN CCK
7 acute pancreatitis 30.1 SST SCT CCK
8 gastroparesis 30.0 SST MLN GAST CCK
9 gastrointestinal system disease 29.9 MLN GAST CCK
10 duodenitis 29.9 GAST ATP4A ATP12A
11 peptic ulcer disease 29.7 SST SCT GAST ATP4A ATP12A
12 hernia, hiatus 29.5 GAST ATP4A ATP12A
13 bile reflux 29.4 SCT GAST CCK CACNA1E ATP4A ATP12A
14 dumping syndrome 29.0 SST SCT PYY NTS MLN GAST
15 peptic esophagitis 28.9 SCT MLN GAST CACNA1E ATP4A ATP12A
16 gastroesophageal reflux 28.9 PYY NTS MLN GAST CCK ATP4A
17 duodenum disease 28.7 SST SCT GAST ATP4A ATP12A
18 biliary dyskinesia 28.6 SST SCT CCK ATP4A ATP12A
19 stomach disease 28.3 SST MLN GAST CCK ATP4A ATP12A
20 constipation 27.5 SST PYY NTS MLN GAST CCK
21 duodenal atresia 11.5
22 gastric ulcer 10.8
23 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.8
24 esophagitis 10.7
25 helicobacter pylori infection 10.6
26 barrett esophagus 10.6
27 atrophic gastritis 10.6
28 gallbladder disease 1 10.6
29 cholecystitis 10.4
30 adenocarcinoma 10.4
31 opisthorchiasis 10.4
32 gastrointestinal neuroendocrine benign tumor 10.3 SST GAST
33 non-functioning pancreatic endocrine tumor 10.3 SST GAST
34 rectum neuroendocrine neoplasm 10.3 SST GAST
35 gastric neuroendocrine neoplasm 10.3 SST GAST
36 appendix lymphoma 10.3 SST GAST
37 pancreatic steatorrhea 10.3 SCT CCK
38 diabetic autonomic neuropathy 10.3 MLN GAST
39 functional colonic disease 10.3 SST MLN
40 gastrointestinal neuroendocrine tumor 10.3 SST GAST
41 carcinoid tumors, intestinal 10.3 SST GAST
42 colonic pseudo-obstruction 10.3 SST MLN
43 enterokinase deficiency 10.3 SCT CCK
44 functionless pituitary adenoma 10.3 SST CCK
45 endometrial small cell carcinoma 10.3 PYY GAST
46 esophageal cancer 10.2
47 choledocholithiasis 10.2
48 48,xyyy 10.2
49 hypotonia 10.2
50 overgrowth syndrome 10.2

Graphical network of the top 20 diseases related to Duodenogastric Reflux:



Diseases related to Duodenogastric Reflux

Symptoms & Phenotypes for Duodenogastric Reflux

MGI Mouse Phenotypes related to Duodenogastric Reflux:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 ATP12A ATP4A CACNA1E CCK GAST NTS

Drugs & Therapeutics for Duodenogastric Reflux

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gastrointestinal Complications in Association With Oropharyngeal and Respiratory Infections in Mechanical Ventilation Unknown status NCT03267693
2 Study of Prognostic Factors for Long Term Results of Total Laparoscopic Fundoplication for Weakly Acidic or Mixed Reflux Completed NCT01741441

Search NIH Clinical Center for Duodenogastric Reflux

Cochrane evidence based reviews: duodenogastric reflux

Genetic Tests for Duodenogastric Reflux

Anatomical Context for Duodenogastric Reflux

MalaCards organs/tissues related to Duodenogastric Reflux:

40
Liver, Testes, Eye, Brain, Heart, Smooth Muscle, Small Intestine

Publications for Duodenogastric Reflux

Articles related to Duodenogastric Reflux:

(show top 50) (show all 836)
# Title Authors PMID Year
1
Effects of duodenogastric reflux on gastrin cells, somatostatin cells and serotonin cells in human antral gastric mucosa. 61 54
15310146 2004
2
Abnormal plasma gut hormones in pathologic duodenogastric reflux and their response to surgery. 54 61
8418694 1993
3
Duodenogastric reflux of bile acids, gastrin and parietal cells, and gastric acid secretion before and 6 months after cholecystectomy. 54 61
2349983 1990
4
Columnar epithelium morphology after esophagectomy: clinical insight into the development of Barrett's esophagus. 61
32383128 2020
5
An Unfortunate Consequence of Duodenogastric Reflux. 61
31404534 2020
6
Clinical, Endoscopic, and Histologic Findings at the Distal Esophagus and Stomach Before and Late (10.5 Years) After Laparoscopic Sleeve Gastrectomy: Results of a Prospective Study with 93% Follow-Up. 61
31583514 2019
7
The Effect of Primary Duodenogastric Bile Reflux on the Presence and Density of Helicobacter pylori and on Gastritis in Childhood. 61
31817518 2019
8
PECULIARITIES OF ACID PRODUCTION AND PATHOGENESIS OF PYLORIC AND PREPYLORIC GASTRIC ULCER COMPLICATIONS. 61
31418722 2019
9
Late esophagogastric anatomic and functional changes after sleeve gastrectomy and its clinical consequences with regards to gastroesophageal reflux disease. 61
31076757 2019
10
Prevalence of Helicobacter pylori is still high among symptomatic Bulgarian children. 61
30585499 2019
11
[CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF THE GASTRODUODENAL MUCOSAL LESIONS IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION WITH DIFFERENT BODY MASS STATUS]. 61
31101780 2019
12
Twenty-four-hour oesophageal pH studies in rural Eastern Cape Province, South Africa. 61
30645964 2018
13
[Progress and controversy on diagnosis and treatment of gastric stump cancer]. 61
29774942 2018
14
Non-Helicobacter pylori Gastric Intestinal Metaplasia in Children: A Series of Cases and Review of the Literature. 61
29850294 2018
15
Oxidative stress from reflux esophagitis to esophageal cancer: the alleviation with antioxidants. 61
27109388 2016
16
Influence of duodenogastric reflux in the gastric mucosa histological changes of rats infected with Helicobacter pylori. 61
27679942 2016
17
Durable Flap-Valve Mitigation of Duodenogastric Reflux,  Remnant Gastritis and Dumping Syndrome Following Billroth I Reconstruction. 61
26666548 2016
18
Considerations on risk factors correlated to the occurrence of gastric stump cancer. 61
27453741 2016
19
Current status in remnant gastric cancer after distal gastrectomy. 61
26937131 2016
20
[Biliary reflux-gastritis: etiology, pathogenesis and modern principles of treatment]. 61
30289664 2016
21
Deoxycholic Acid Could Induce Apoptosis and Trigger Gastric Carcinogenesis on Gastric Epithelial Cells by Quantitative Proteomic Analysis. 61
28070185 2016
22
Cholecystectomy and duodenogastric reflux: interacting effects over the gastric mucosa. 61
27917345 2016
23
[MECHANISMS OF GASTRODUODENAL DYSMOTILITY UNDER STRESS]. 61
27301116 2016
24
[Diagnosis of sphincter of Oddi dysfunction in patients with postcholecystectomy syndrome from hepatobiliary scintigraphic findings]. 61
26999929 2015
25
Heterotopic Gastric Mucosa in the Distal Part of Esophagus in a Teenager: Case Report. 61
26496283 2015
26
Common Mechanism of Pathogenesis in Gastrointestinal Diseases Implied by Consistent Efficacy of Single Chinese Medicine Formula: A PRISMA-Compliant Systematic Review and Meta-Analysis. 61
26166106 2015
27
Pepsin and bile acids in saliva in patients with laryngopharyngeal reflux - a prospective comparative study. 61
25516364 2015
28
[DISSEMINATION BY H. PYLORI IN PATIENTS, SUFFERING VARIOUS FORMS OF CHOLECYSTITIS]. 61
26419024 2015
29
Defective upper gastrointestinal function after repair of combined esophageal and duodenal atresia. 61
25840057 2015
30
24-Hour Measurement of Gastric pH in Rural South Africa. 61
25861260 2015
31
Current status of function-preserving surgery for gastric cancer. 61
25516640 2014
32
Potential mechanism of corpus-predominant gastritis after PPI therapy in Helicobacter pylori-positive patients with GERD. 61
25232231 2014
33
Peculiarities of gastrointestinal disease concomitant to heart connective tissue dysplasia in children born from persons exposed to ionizing radiation in childhood after the ChNPP accident. 61
25536566 2014
34
LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3. 61
24674670 2014
35
[Gastroesophageal reflux disease associated with duodenogastroesophageal reflux in patients with biliary pathology: the specific features of the course and esophagogastroduodenal microbial biocenosis]. 61
24772502 2014
36
[Indications for surgical treatment of hard scarring gastric ulcers]. 61
24781063 2014
37
Automatic motion analysis system for pyloric flow in ultrasonic videos. 61
24403410 2014
38
Elevated serum dopamine increases while coffee consumption decreases the occurrence of reddish streaks in the intact stomach. 61
23800237 2013
39
Operatively induced chronic reflux in rats: a suitable model for studying esophageal carcinogenesis? 61
24084597 2013
40
A flow visualization model of duodenogastric reflux after esophagectomy with gastric interposition. 61
24067071 2013
41
The role of duodenogastric reflux in formation of precarcinogenic gastric lesions--an experimental study. 61
24069809 2013
42
Spontaneous clearance of Helicobacter pylori after pylorus-preserving gastrectomy for gastric cancer. 61
23673508 2013
43
Late administration of a specific COX-2 inhibitor does not treat and/or prevent progression of gastric tumors in rats submitted to duodenogastric reflux procedure. 61
23743684 2013
44
Weighted cross-correlation based variational optical flow for gastric flow analysis in ultrasonic videos. 61
23635294 2013
45
Endotoxin-induced changes in phospholipid dynamics of the stomach. 61
23158407 2013
46
Atrophic gastritis: Helicobacter pylori versus duodenogastric reflux. 61
26527935 2013
47
Comparative evaluation of intragastric bile acids and hepatobiliary scintigraphy in the diagnosis of duodenogastric reflux. 61
23599645 2013
48
Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract. 61
22928604 2012
49
Transposed intrathoracic stomach: functional evaluation. 61
23250242 2012
50
Patients with partial gastrectomy and Barrett esophagus are in higher risk to develop esophageal adenocarcinoma than those with Barretts without gastrectomy. 61
22580662 2012

Variations for Duodenogastric Reflux

Expression for Duodenogastric Reflux

Search GEO for disease gene expression data for Duodenogastric Reflux.

Pathways for Duodenogastric Reflux

GO Terms for Duodenogastric Reflux

Cellular components related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 SST SCT PYY GAST CCK ATP4A
2 extracellular region GO:0005576 9.17 SST SCT PYY NTS MLN GAST

Biological processes related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.4 ATP4A ATP12A
2 digestion GO:0007586 9.37 SST CCK
3 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.26 ATP4A ATP12A
5 G protein-coupled receptor signaling pathway GO:0007186 9.17 SST SCT PYY NTS MLN GAST
6 cellular potassium ion homeostasis GO:0030007 9.16 ATP4A ATP12A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.96 ATP4A ATP12A

Molecular functions related to Duodenogastric Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 9.26 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 9.16 ATP4A ATP12A
4 neuropeptide hormone activity GO:0005184 9.13 PYY NTS CCK
5 hormone activity GO:0005179 9.1 SST SCT PYY MLN GAST CCK

Sources for Duodenogastric Reflux

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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