MCID: DDN003
MIFTS: 35

Duodenum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Duodenum Adenocarcinoma

MalaCards integrated aliases for Duodenum Adenocarcinoma:

Name: Duodenum Adenocarcinoma 12 15
Duodenal Adenocarcinoma 12 29 6
Adenocarcinoma of Duodenum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10816
NCIt 50 C7889
UMLS 73 C0278804

Summaries for Duodenum Adenocarcinoma

Disease Ontology : 12 A duodenum cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Duodenum Adenocarcinoma, also known as duodenal adenocarcinoma, is related to papillary adenocarcinoma and villous adenoma. An important gene associated with Duodenum Adenocarcinoma is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways is CLEC7A (Dectin-1) signaling. Affiliated tissues include colon, lymph node and pancreas.

Related Diseases for Duodenum Adenocarcinoma

Diseases related to Duodenum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 papillary adenocarcinoma 29.7 KRT7 MUC2
2 villous adenoma 29.7 CDX2 KRAS
3 cholecystitis 29.6 MUC2 MUC6
4 mucinous adenocarcinoma 29.3 CDX2 KRAS KRT7 MUC2
5 gastric cancer 29.2 CDX2 KRAS MUC2 MUC6
6 cervical polyp 10.1 CDX2 MUC6
7 solid adenocarcinoma with mucin production 10.1 KRT7 MUC6
8 endocervical carcinoma 10.1 KRT7 MUC6
9 adenomyoma 10.1 KRT7 MUC6
10 cervical adenosquamous carcinoma 10.1 KRT7 MUC6
11 tumor of exocrine pancreas 10.1 MUC2 MUC6
12 small intestine adenocarcinoma 10.1 MUC2 MUC6
13 pancreatic intraductal papillary-mucinous neoplasm 10.1 MUC2 MUC6
14 chronic ethmoiditis 10.1 MUC2 MUC6
15 teratoma 10.1 CDX2 KRT7
16 cervical adenocarcinoma 10.1 CDX2 KRT7
17 ethmoid sinusitis 10.1 MUC2 MUC6
18 ovary neuroendocrine neoplasm 10.1 CDX2 KRT7
19 alveoli adenoma 10.1 KRAS KRT7
20 appendix adenocarcinoma 10.1 CDX2 KRT7
21 mucinous adenofibroma 10.1 CDX2 KRT7
22 anus adenocarcinoma 10.1 CDX2 KRT7
23 glandular cystitis 10.1 CDX2 KRT7
24 epithelial predominant wilms' tumor 10.1 CDX2 KRT7
25 jejunal adenocarcinoma 10.1 CDX2 KRT7
26 nasal cavity cancer 10.1 CDX2 KRT7
27 thymus adenocarcinoma 10.1 CDX2 KRT7
28 gastric diffuse adenocarcinoma 10.1 CDX2 KRT7
29 adenosquamous carcinoma 10.1 KRAS KRT7
30 bladder adenocarcinoma 10.1 CDX2 KRT7
31 chronic cystitis 10.1 CDX2 KRT7
32 vulva adenocarcinoma 10.1 CDX2 KRT7
33 tn polyagglutination syndrome 10.1 MUC2 MUC6
34 rectum adenocarcinoma 10.1 CDX2 KRT7
35 mucinous ovarian cystadenoma 10.1 CDX2 KRT7
36 tubular adenocarcinoma 10.1 CDX2 MUC2
37 mucinous bronchioloalveolar adenocarcinoma 10.1 CDX2 KRT7
38 cystadenocarcinoma 10.1 KRT7 MUC2
39 gastrointestinal system benign neoplasm 10.1 KRAS KRT7
40 prostatic acinar adenocarcinoma 10.0 CDX2 KRT7
41 epstein-barr virus-associated gastric carcinoma 10.0 MUC2 MUC6
42 ovary adenocarcinoma 10.0 KRAS KRT7
43 colorectal cancer 1 10.0 MUC2 MUC6
44 colloid carcinoma of the pancreas 10.0 KRAS MUC2
45 eyelid carcinoma 10.0 KRT7 MUC2
46 horseshoe kidney 10.0 CDX2 KRT7
47 bile duct mucoepidermoid carcinoma 10.0 KRT7 MUC2
48 ovarian clear cell carcinoma 10.0 KRAS KRT7
49 mucoepidermoid carcinoma 10.0 KRT7 MUC2
50 anus cancer 10.0 CDX2 KRT7

Graphical network of the top 20 diseases related to Duodenum Adenocarcinoma:



Diseases related to Duodenum Adenocarcinoma

Symptoms & Phenotypes for Duodenum Adenocarcinoma

Drugs & Therapeutics for Duodenum Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Duodenum Adenocarcinoma

Genetic Tests for Duodenum Adenocarcinoma

Genetic tests related to Duodenum Adenocarcinoma:

# Genetic test Affiliating Genes
1 Duodenal Adenocarcinoma 29

Anatomical Context for Duodenum Adenocarcinoma

MalaCards organs/tissues related to Duodenum Adenocarcinoma:

41
Colon, Lymph Node, Pancreas, Lung, Ovary, Small Intestine, Appendix

Publications for Duodenum Adenocarcinoma

Articles related to Duodenum Adenocarcinoma:

(show top 50) (show all 115)
# Title Authors Year
1
ASO Author Reflections: Current Treatment Options for Duodenal Adenocarcinoma-A Call for Collaborative Studies. ( 30327972 )
2018
2
Personalized treatment based on mini patient-derived xenografts and WES/RNA sequencing in a patient with metastatic duodenal adenocarcinoma. ( 30139386 )
2018
3
Duodenal adenocarcinoma successfully diagnosed with transabdominal ultrasonography. ( 28439673 )
2018
4
Effect of postoperative radiotherapy on survival in duodenal adenocarcinoma: a propensity score-adjusted analysis of Surveillance, Epidemiology, and End Results database. ( 29260430 )
2018
5
Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report. ( 29281782 )
2018
6
"Duodenal Adenocarcinoma Giving Rise to Rectal Metastasis" a Rare Disease with an Extremely Rare Metastatic Pattern. ( 29392602 )
2018
7
Pancreas-sparing and superior mesenteric artery first approach in duodenal adenocarcinoma of the fourth portion of duodenum: A case report. ( 29558711 )
2018
8
Neoadjuvant chemotherapy in locally advanced duodenal adenocarcinoma. ( 29662529 )
2018
9
Prognosis and nomogram for predicting postoperative survival of duodenal adenocarcinoma: A retrospective study in China and the SEER database. ( 29786691 )
2018
10
Outcomes of surgical resection for primary duodenal adenocarcinoma: A systematic review. ( 29802028 )
2018
11
Prognostic factors of non-ampullary duodenal adenocarcinoma. ( 29931295 )
2018
12
Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis. ( 29946997 )
2018
13
Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma. ( 29956011 )
2018
14
Accuracy of biopsy for the preoperative diagnosis of superficial nonampullary duodenal adenocarcinoma. ( 28003118 )
2017
15
Clival Metastasis of a Duodenal Adenocarcinoma: A Case Report and Literature Review. ( 28034818 )
2017
16
Stereotactic ablative radiation therapy as a potential curative treatment in duodenal adenocarcinoma: a case report. ( 28218383 )
2017
17
Helical tomotherapy for duodenal adenocarcinoma in an elderly patient: A case report. ( 28255431 )
2017
18
Adjuvant chemotherapy versus chemoradiotherapy in the management of patients with surgically resected duodenal adenocarcinoma: A propensity score-matched analysis of a nationwide clinical oncology database. ( 28263387 )
2017
19
Optimal Lymphadenectomy for Duodenal Adenocarcinoma: Does the Number Alone Matter? ( 28799027 )
2017
20
Characteristics and risk factors for sporadic non-ampullary duodenal adenocarcinoma. ( 28830268 )
2017
21
Pathologic Response to Preoperative Therapy as a Novel Prognosticator for Ampullary and Duodenal Adenocarcinoma. ( 28980211 )
2017
22
Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma. ( 27643594 )
2016
23
Duodenal Adenocarcinoma Metastatic to the Breast: A Case Report. ( 26986146 )
2016
24
Whole-exome sequencing of duodenal adenocarcinoma identifies recurrent Wnt/β-catenin signaling pathway mutations. ( 26998897 )
2016
25
Duodenal adenocarcinoma: Advances in diagnosis and surgical management. ( 27022448 )
2016
26
Metastasis of extra-ampullary duodenal adenocarcinoma to the uterine cervix. ( 27126664 )
2016
27
Duodenal Adenocarcinoma Diagnosed from a Biopsy Specimen of a Depressed Lesion Obtained by Magnifying Endoscopy. ( 27403120 )
2016
28
Lymph node evaluation and survival after curative-intent resection of duodenal adenocarcinoma: A matched cohort study. ( 27821316 )
2016
29
Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from China. ( 28116301 )
2016
30
Duodenal adenocarcinoma: A rare cause of chyloperitoneum (chylous ascites). ( 26837993 )
2015
31
Clinicopathological characterisation of duodenal adenocarcinoma with high CD44 variant 9 expression. ( 26517627 )
2015
32
Does the extent of resection impact survival for duodenal adenocarcinoma? Analysis of 1,611 cases. ( 25160736 )
2015
33
Outcome after surgical resection for duodenal adenocarcinoma in the UK. ( 25776995 )
2015
34
Human Epidermal Growth Factor Receptor 2-Positive Duodenal Adenocarcinoma: A Case Report and Review of the Literature. ( 26351435 )
2015
35
S-1 treatment leading to complete remission of advanced duodenal adenocarcinoma: A case report. ( 26623074 )
2015
36
Duodenal Adenocarcinoma: Profile and Predictors of Survival Outcomes. ( 26672582 )
2015
37
Prognosis value of mitotic kinase Aurora-A for primary duodenal adenocarcinoma. ( 24943686 )
2014
38
Long-term outcomes in patients with duodenal adenocarcinoma. ( 23656271 )
2014
39
Duodenal adenocarcinoma presenting as a mass with aneurismal dilatation. ( 24411203 )
2014
40
Duodenal adenocarcinoma following a neuroendocrine tumor in the duodenum. ( 24574838 )
2014
41
Complete response and prolonged disease-free survival in a patient with recurrent duodenal adenocarcinoma treated with bevacizumab plus FOLFOX6. ( 24490045 )
2014
42
Defining the role of adjuvant therapy: ampullary and duodenal adenocarcinoma. ( 24635865 )
2014
43
Duodenal adenocarcinoma in a 10-year-old boy. ( 24647303 )
2014
44
Clinicopathological analysis and survival outcome of duodenal adenocarcinoma. ( 24751389 )
2014
45
Primary Duodenal Adenocarcinoma without Stenosis: A Case Report with a Brief Literature Review. ( 25120470 )
2014
46
Duodenal adenocarcinoma: why the extreme rarity of duodenal bulb primary tumors? ( 25264638 )
2014
47
Wilkie's Syndrome and Left Adnexal Mass: Unusual Presentation of Duodenal Adenocarcinoma. ( 25302201 )
2014
48
Extra-ampullary duodenal adenocarcinoma. ( 25310836 )
2014
49
A safe approach to perform endoscopic mucosal resection of a duodenal adenocarcinoma located close to a duodenal diverticulum. ( 25526422 )
2014
50
Radical surgical management of periampullary duodenal adenocarcinoma: a single institution experience. ( 25831642 )
2014

Variations for Duodenum Adenocarcinoma

ClinVar genetic disease variations for Duodenum Adenocarcinoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_001127511.2(APC): c.2504A> G (p.Glu835Gly) single nucleotide variant Uncertain significance GRCh37 Chromosome 5, 112173849: 112173849
2 APC NM_001127511.2(APC): c.2504A> G (p.Glu835Gly) single nucleotide variant Uncertain significance GRCh38 Chromosome 5, 112838152: 112838152
3 APC NM_000038.5(APC): c.1984C> A (p.Leu662Ile) single nucleotide variant Uncertain significance rs756859993 GRCh38 Chromosome 5, 112837578: 112837578
4 APC NM_000038.5(APC): c.1984C> A (p.Leu662Ile) single nucleotide variant Uncertain significance rs756859993 GRCh37 Chromosome 5, 112173275: 112173275

Expression for Duodenum Adenocarcinoma

Search GEO for disease gene expression data for Duodenum Adenocarcinoma.

Pathways for Duodenum Adenocarcinoma

Pathways related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.21 KRAS MUC2 MUC6

GO Terms for Duodenum Adenocarcinoma

Biological processes related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 O-glycan processing GO:0016266 9.16 MUC2 MUC6
2 maintenance of gastrointestinal epithelium GO:0030277 8.96 MUC2 MUC6
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.8 KRAS MUC2 MUC6

Sources for Duodenum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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