MCID: DDN003
MIFTS: 37

Duodenum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Duodenum Adenocarcinoma

MalaCards integrated aliases for Duodenum Adenocarcinoma:

Name: Duodenum Adenocarcinoma 12 15
Duodenal Adenocarcinoma 12 6 17

Classifications:



External Ids:

Disease Ontology 12 DOID:10816
NCIt 51 C7889
UMLS 74 C0278804

Summaries for Duodenum Adenocarcinoma

Disease Ontology : 12 A duodenum cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Duodenum Adenocarcinoma, also known as duodenal adenocarcinoma, is related to villous adenoma and adenocarcinoma. An important gene associated with Duodenum Adenocarcinoma is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are VEGF Pathway (Qiagen) and CLEC7A (Dectin-1) signaling. The drugs Pancrelipase and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, pancreas and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Duodenum Adenocarcinoma

Diseases related to Duodenum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 villous adenoma 29.5 CDX2 KRAS
2 adenocarcinoma 10.8
3 solid adenocarcinoma with mucin production 10.3 KRT7 MUC6
4 bile duct cystadenocarcinoma 10.3 KRT7 MUC6
5 endocervical carcinoma 10.2 KRT7 MUC6
6 adenomyoma 10.2 KRT7 MUC6
7 cystadenoma 10.2 KRT7 MUC6
8 mucinous tubular and spindle renal cell carcinoma 10.2 KRT7 MUC6
9 cervical adenosquamous carcinoma 10.2 KRT7 MUC6
10 cystadenocarcinoma 10.1 HRAS KRT7
11 sigmoid neoplasm 10.1 HRAS KRAS
12 apocrine adenoma 10.1 HRAS KRAS
13 prostate squamous cell carcinoma 10.1 HRAS KRT7
14 periampullary adenoma 10.1 HRAS KRAS
15 paronychia 10.1 HRAS KRAS
16 alveoli adenoma 10.1 KRAS KRT7
17 schimmelpenning-feuerstein-mims syndrome 10.1 HRAS KRAS
18 bile duct cysts 10.1 HRAS KRAS
19 aggressive digital papillary adenocarcinoma 10.1 HRAS KRAS
20 pancreatic ductal carcinoma 10.1 KRT7 MUC6
21 lung adenoid cystic carcinoma 10.1 HRAS KRAS
22 epithelial-myoepithelial carcinoma 10.1 HRAS KRT7
23 secondary hypertrophic osteoarthropathy 10.1 HRAS KRAS
24 adenosquamous carcinoma 10.1 KRAS KRT7
25 pancreatic mucinous cystadenoma 10.1 HRAS KRT7
26 ovarian cystadenocarcinoma 10.1 HRAS KRAS
27 acneiform dermatitis 10.1 HRAS KRAS
28 colloid carcinoma of the pancreas 10.1 HRAS KRAS
29 mucinous intrahepatic cholangiocarcinoma 10.1 CDX2 MUC6
30 mixed cell type cancer 10.1 HRAS KRT7
31 cervical polyp 10.1 CDX2 MUC6
32 core binding factor acute myeloid leukemia 10.0 HRAS KRAS
33 mucinous lung adenocarcinoma 10.0 HRAS KRAS
34 cervical adenocarcinoma 10.0 CDX2 KRT7
35 liver angiosarcoma 10.0 HRAS KRAS
36 adenosquamous lung carcinoma 10.0 HRAS KRAS
37 ovary neuroendocrine neoplasm 10.0 CDX2 KRT7
38 superior mesenteric artery syndrome 10.0 CDX2 MUC6
39 appendix adenocarcinoma 10.0 CDX2 KRT7
40 mucinous adenofibroma 10.0 CDX2 KRT7
41 anus adenocarcinoma 10.0 CDX2 KRT7
42 glandular cystitis 10.0 CDX2 KRT7
43 epithelial predominant wilms' tumor 10.0 CDX2 KRT7
44 costello syndrome 10.0 HRAS KRAS
45 jejunal adenocarcinoma 10.0 CDX2 KRT7
46 nasal cavity cancer 10.0 CDX2 KRT7
47 ovarian mucinous adenocarcinoma 10.0 CDX2 KRT7
48 thymus adenocarcinoma 10.0 CDX2 KRT7
49 gastric diffuse adenocarcinoma 10.0 CDX2 KRT7
50 chronic cystitis 10.0 CDX2 KRT7

Graphical network of the top 20 diseases related to Duodenum Adenocarcinoma:



Diseases related to Duodenum Adenocarcinoma

Symptoms & Phenotypes for Duodenum Adenocarcinoma

GenomeRNAi Phenotypes related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

27 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.58 KRAS
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.58 RAD17
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.58 KRAS
4 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.58 RAD17
5 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.58 KRAS
6 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.58 KRAS
7 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.58 HRAS
8 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.58 HRAS KRAS RAD17
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.58 RAD17
10 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.58 KRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.58 HRAS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.58 KRAS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.58 KRAS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.58 KRAS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.58 HRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.58 KRAS

Drugs & Therapeutics for Duodenum Adenocarcinoma

Drugs for Duodenum Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
2 Gastrointestinal Agents Not Applicable
3 pancreatin Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis (FAP) Unknown status NCT02656134
2 Pancreatic Head and Peri-ampullary Cancer Laparoscopic vs Open Surgical Treatment Trial (PLOT) Completed NCT02081131 Not Applicable
3 Periampullary Lesions Via ERCP in Assuit University Hospital Recruiting NCT03185390 Not Applicable
4 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable

Search NIH Clinical Center for Duodenum Adenocarcinoma

Genetic Tests for Duodenum Adenocarcinoma

Anatomical Context for Duodenum Adenocarcinoma

MalaCards organs/tissues related to Duodenum Adenocarcinoma:

42
Lung, Pancreas, Ovary, Appendix, Liver, Lymph Node, Prostate

Publications for Duodenum Adenocarcinoma

Articles related to Duodenum Adenocarcinoma:

(show top 50) (show all 121)
# Title Authors Year
1
Durable response for ampullary and duodenal adenocarcinoma with a nab-paclitaxel plus gemcitabine ± cisplatin combination. ( 31102323 )
2019
2
Tumour stage and resection margin status are independent survival factors following partial pancreatoduodenectomy for duodenal adenocarcinoma. ( 30972486 )
2019
3
Outcomes of surgical resection for primary duodenal adenocarcinoma: A systematic review. ( 29802028 )
2019
4
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy. ( 30713128 )
2019
5
Functional Expression of Mucin1 in Human Duodenal Adenocarcinoma. ( 30763811 )
2019
6
Endoscopic submucosal dissection of duodenal adenocarcinoma arising from Brunner's gland. ( 31040631 )
2019
7
Duodenal adenocarcinoma successfully diagnosed with transabdominal ultrasonography. ( 28439673 )
2018
8
Effect of postoperative radiotherapy on survival in duodenal adenocarcinoma: a propensity score-adjusted analysis of Surveillance, Epidemiology, and End Results database. ( 29260430 )
2018
9
Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report. ( 29281782 )
2018
10
"Duodenal Adenocarcinoma Giving Rise to Rectal Metastasis" a Rare Disease with an Extremely Rare Metastatic Pattern. ( 29392602 )
2018
11
Pancreas-sparing and superior mesenteric artery first approach in duodenal adenocarcinoma of the fourth portion of duodenum: A case report. ( 29558711 )
2018
12
Neoadjuvant chemotherapy in locally advanced duodenal adenocarcinoma. ( 29662529 )
2018
13
Prognosis and nomogram for predicting postoperative survival of duodenal adenocarcinoma: A retrospective study in China and the SEER database. ( 29786691 )
2018
14
Prognostic factors of non-ampullary duodenal adenocarcinoma. ( 29931295 )
2018
15
Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma. ( 29956011 )
2018
16
Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis. ( 29946997 )
2018
17
Personalized treatment based on mini patient-derived xenografts and WES/RNA sequencing in a patient with metastatic duodenal adenocarcinoma. ( 30139386 )
2018
18
ASO Author Reflections: Current Treatment Options for Duodenal Adenocarcinoma-A Call for Collaborative Studies. ( 30327972 )
2018
19
Duodenal Adenocarcinoma in a Patient with Partial Intestinal Malrotation. ( 30631855 )
2018
20
Accuracy of biopsy for the preoperative diagnosis of superficial nonampullary duodenal adenocarcinoma. ( 28003118 )
2017
21
Clival Metastasis of a Duodenal Adenocarcinoma: A Case Report and Literature Review. ( 28034818 )
2017
22
Stereotactic ablative radiation therapy as a potential curative treatment in duodenal adenocarcinoma: a case report. ( 28218383 )
2017
23
Helical tomotherapy for duodenal adenocarcinoma in an elderly patient: A case report. ( 28255431 )
2017
24
Adjuvant chemotherapy versus chemoradiotherapy in the management of patients with surgically resected duodenal adenocarcinoma: A propensity score-matched analysis of a nationwide clinical oncology database. ( 28263387 )
2017
25
Optimal Lymphadenectomy for Duodenal Adenocarcinoma: Does the Number Alone Matter? ( 28799027 )
2017
26
Characteristics and risk factors for sporadic non-ampullary duodenal adenocarcinoma. ( 28830268 )
2017
27
Pathologic Response to Preoperative Therapy as a Novel Prognosticator for Ampullary and Duodenal Adenocarcinoma. ( 28980211 )
2017
28
Duodenal Adenocarcinoma Metastatic to the Breast: A Case Report. ( 26986146 )
2016
29
Whole-exome sequencing of duodenal adenocarcinoma identifies recurrent Wnt/β-catenin signaling pathway mutations. ( 26998897 )
2016
30
Duodenal adenocarcinoma: Advances in diagnosis and surgical management. ( 27022448 )
2016
31
Metastasis of extra-ampullary duodenal adenocarcinoma to the uterine cervix. ( 27126664 )
2016
32
Duodenal Adenocarcinoma Diagnosed from a Biopsy Specimen of a Depressed Lesion Obtained by Magnifying Endoscopy. ( 27403120 )
2016
33
Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma. ( 27643594 )
2016
34
Lymph node evaluation and survival after curative-intent resection of duodenal adenocarcinoma: A matched cohort study. ( 27821316 )
2016
35
Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from China. ( 28116301 )
2016
36
Human Epidermal Growth Factor Receptor 2-Positive Duodenal Adenocarcinoma: A Case Report and Review of the Literature. ( 26351435 )
2015
37
Clinicopathological characterisation of duodenal adenocarcinoma with high CD44 variant 9 expression. ( 26517627 )
2015
38
S-1 treatment leading to complete remission of advanced duodenal adenocarcinoma: A case report. ( 26623074 )
2015
39
Duodenal Adenocarcinoma: Profile and Predictors of Survival Outcomes. ( 26672582 )
2015
40
Duodenal adenocarcinoma: A rare cause of chyloperitoneum (chylous ascites). ( 26837993 )
2015
41
Outcome after surgical resection for duodenal adenocarcinoma in the UK. ( 25776995 )
2015
42
Does the extent of resection impact survival for duodenal adenocarcinoma? Analysis of 1,611 cases. ( 25160736 )
2015
43
Duodenal adenocarcinoma following a neuroendocrine tumor in the duodenum. ( 24574838 )
2014
44
Radical surgical management of periampullary duodenal adenocarcinoma: a single institution experience. ( 25831642 )
2014
45
A safe approach to perform endoscopic mucosal resection of a duodenal adenocarcinoma located close to a duodenal diverticulum. ( 25526422 )
2014
46
Extra-ampullary duodenal adenocarcinoma. ( 25310836 )
2014
47
Wilkie's Syndrome and Left Adnexal Mass: Unusual Presentation of Duodenal Adenocarcinoma. ( 25302201 )
2014
48
Duodenal adenocarcinoma: why the extreme rarity of duodenal bulb primary tumors? ( 25264638 )
2014
49
Primary Duodenal Adenocarcinoma without Stenosis: A Case Report with a Brief Literature Review. ( 25120470 )
2014
50
Prognosis value of mitotic kinase Aurora-A for primary duodenal adenocarcinoma. ( 24943686 )
2014

Variations for Duodenum Adenocarcinoma

ClinVar genetic disease variations for Duodenum Adenocarcinoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.1984C> A (p.Leu662Ile) single nucleotide variant Uncertain significance rs756859993 GRCh37 Chromosome 5, 112173275: 112173275
2 APC NM_000038.5(APC): c.1984C> A (p.Leu662Ile) single nucleotide variant Uncertain significance rs756859993 GRCh38 Chromosome 5, 112837578: 112837578
3 APC NM_001127511.2(APC): c.2504A> G (p.Glu835Gly) single nucleotide variant Uncertain significance rs1554084263 GRCh37 Chromosome 5, 112173849: 112173849
4 APC NM_001127511.2(APC): c.2504A> G (p.Glu835Gly) single nucleotide variant Uncertain significance rs1554084263 GRCh38 Chromosome 5, 112838152: 112838152

Expression for Duodenum Adenocarcinoma

Search GEO for disease gene expression data for Duodenum Adenocarcinoma.

Pathways for Duodenum Adenocarcinoma

GO Terms for Duodenum Adenocarcinoma

Biological processes related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitotic cell cycle checkpoint GO:0007093 9.26 HRAS RAD17
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 HRAS KRAS
3 response to isolation stress GO:0035900 8.96 HRAS KRAS
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.8 HRAS KRAS MUC6

Sources for Duodenum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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