MCID: DDN003
MIFTS: 38

Duodenum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Duodenum Adenocarcinoma

MalaCards integrated aliases for Duodenum Adenocarcinoma:

Name: Duodenum Adenocarcinoma 12 15
Duodenal Adenocarcinoma 12 30 6 17

Classifications:



External Ids:

Disease Ontology 12 DOID:10816
NCIt 51 C7889
UMLS 74 C0278804

Summaries for Duodenum Adenocarcinoma

Disease Ontology : 12 A duodenum cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Duodenum Adenocarcinoma, also known as duodenal adenocarcinoma, is related to villous adenoma and solid adenocarcinoma with mucin production. An important gene associated with Duodenum Adenocarcinoma is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are VEGF Pathway (Qiagen) and CLEC7A (Dectin-1) signaling. The drugs Pancrelipase and pancreatin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, liver and pancreas, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Duodenum Adenocarcinoma

Diseases related to Duodenum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 villous adenoma 29.5 CDX2 KRAS
2 solid adenocarcinoma with mucin production 10.2 KRT7 MUC6
3 bile duct cystadenocarcinoma 10.2 KRT7 MUC6
4 endocervical carcinoma 10.2 KRT7 MUC6
5 adenomyoma 10.2 KRT7 MUC6
6 cystadenoma 10.2 KRT7 MUC6
7 mucinous tubular and spindle renal cell carcinoma 10.2 KRT7 MUC6
8 sigmoid neoplasm 10.2 HRAS KRAS
9 apocrine adenoma 10.2 HRAS KRAS
10 periampullary adenoma 10.2 HRAS KRAS
11 paronychia 10.2 HRAS KRAS
12 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS KRAS
13 cervical adenosquamous carcinoma 10.1 KRT7 MUC6
14 bile duct cysts 10.1 HRAS KRAS
15 aggressive digital papillary adenocarcinoma 10.1 HRAS KRAS
16 lung adenoid cystic carcinoma 10.1 HRAS KRAS
17 secondary hypertrophic osteoarthropathy 10.1 HRAS KRAS
18 alveoli adenoma 10.1 KRAS KRT7
19 ovarian cystadenocarcinoma 10.1 HRAS KRAS
20 cystadenocarcinoma 10.1 HRAS KRT7
21 acneiform dermatitis 10.1 HRAS KRAS
22 colloid carcinoma of the pancreas 10.1 HRAS KRAS
23 prostate squamous cell carcinoma 10.1 HRAS KRT7
24 adenosquamous carcinoma 10.1 KRAS KRT7
25 core binding factor acute myeloid leukemia 10.1 HRAS KRAS
26 pancreatic ductal carcinoma 10.1 KRT7 MUC6
27 mucinous lung adenocarcinoma 10.1 HRAS KRAS
28 mucinous intrahepatic cholangiocarcinoma 10.1 CDX2 MUC6
29 epithelial-myoepithelial carcinoma 10.1 HRAS KRT7
30 cervical polyp 10.0 CDX2 MUC6
31 liver angiosarcoma 10.0 HRAS KRAS
32 pancreatic mucinous cystadenoma 10.0 HRAS KRT7
33 adenosquamous lung carcinoma 10.0 HRAS KRAS
34 mixed cell type cancer 10.0 HRAS KRT7
35 costello syndrome 10.0 HRAS KRAS
36 superior mesenteric artery syndrome 10.0 CDX2 MUC6
37 exanthem 10.0 HRAS KRAS
38 cervical adenocarcinoma 10.0 CDX2 KRT7
39 pulmonic stenosis 10.0 HRAS KRAS
40 ovary neuroendocrine neoplasm 10.0 CDX2 KRT7
41 appendix adenocarcinoma 9.9 CDX2 KRT7
42 ovarian clear cell carcinoma 9.9 KRAS KRT7
43 mucinous adenofibroma 9.9 CDX2 KRT7
44 anus adenocarcinoma 9.9 CDX2 KRT7
45 glandular cystitis 9.9 CDX2 KRT7
46 epithelial predominant wilms' tumor 9.9 CDX2 KRT7
47 jejunal adenocarcinoma 9.9 CDX2 KRT7
48 nasal cavity cancer 9.9 CDX2 KRT7
49 ovarian mucinous adenocarcinoma 9.9 CDX2 KRT7
50 thymus adenocarcinoma 9.9 CDX2 KRT7

Graphical network of the top 20 diseases related to Duodenum Adenocarcinoma:



Diseases related to Duodenum Adenocarcinoma

Symptoms & Phenotypes for Duodenum Adenocarcinoma

GenomeRNAi Phenotypes related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

27 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.6 KRAS
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.6 RAD17
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.6 KRAS
4 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.6 RAD17
5 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.6 KRAS
6 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.6 KRAS
7 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.6 HRAS
8 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.6 HRAS KRAS RAD17
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.6 RAD17
10 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.6 KRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.6 KRAS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.6 HRAS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.6 KRAS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.6 KRAS
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.6 KRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.6 HRAS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.6 KRAS

Drugs & Therapeutics for Duodenum Adenocarcinoma

Drugs for Duodenum Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
2 pancreatin Not Applicable
3 Gastrointestinal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis (FAP) Unknown status NCT02656134
2 Pancreatic Head and Peri-ampullary Cancer Laparoscopic vs Open Surgical Treatment Trial (PLOT) Completed NCT02081131 Not Applicable
3 Periampullary Lesions Via ERCP in Assuit University Hospital Recruiting NCT03185390 Not Applicable
4 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable

Search NIH Clinical Center for Duodenum Adenocarcinoma

Genetic Tests for Duodenum Adenocarcinoma

Genetic tests related to Duodenum Adenocarcinoma:

# Genetic test Affiliating Genes
1 Duodenal Adenocarcinoma 30

Anatomical Context for Duodenum Adenocarcinoma

MalaCards organs/tissues related to Duodenum Adenocarcinoma:

42
Lymph Node, Liver, Pancreas, Breast, Cervix, Thyroid

Publications for Duodenum Adenocarcinoma

Articles related to Duodenum Adenocarcinoma:

(show top 50) (show all 118)
# Title Authors Year
1
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy. ( 30713128 )
2019
2
Functional Expression of Mucin1 in Human Duodenal Adenocarcinoma. ( 30763811 )
2019
3
Outcomes of surgical resection for primary duodenal adenocarcinoma: A systematic review. ( 29802028 )
2019
4
Duodenal Adenocarcinoma in a Patient with Partial Intestinal Malrotation. ( 30631855 )
2018
5
ASO Author Reflections: Current Treatment Options for Duodenal Adenocarcinoma-A Call for Collaborative Studies. ( 30327972 )
2018
6
Personalized treatment based on mini patient-derived xenografts and WES/RNA sequencing in a patient with metastatic duodenal adenocarcinoma. ( 30139386 )
2018
7
Prognostic factors of non-ampullary duodenal adenocarcinoma. ( 29931295 )
2018
8
Outcomes and Treatment Options for Duodenal Adenocarcinoma: A Systematic Review and Meta-Analysis. ( 29946997 )
2018
9
Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma. ( 29956011 )
2018
10
Duodenal adenocarcinoma successfully diagnosed with transabdominal ultrasonography. ( 28439673 )
2018
11
Effect of postoperative radiotherapy on survival in duodenal adenocarcinoma: a propensity score-adjusted analysis of Surveillance, Epidemiology, and End Results database. ( 29260430 )
2018
12
Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report. ( 29281782 )
2018
13
"Duodenal Adenocarcinoma Giving Rise to Rectal Metastasis" a Rare Disease with an Extremely Rare Metastatic Pattern. ( 29392602 )
2018
14
Pancreas-sparing and superior mesenteric artery first approach in duodenal adenocarcinoma of the fourth portion of duodenum: A case report. ( 29558711 )
2018
15
Neoadjuvant chemotherapy in locally advanced duodenal adenocarcinoma. ( 29662529 )
2018
16
Prognosis and nomogram for predicting postoperative survival of duodenal adenocarcinoma: A retrospective study in China and the SEER database. ( 29786691 )
2018
17
Helical tomotherapy for duodenal adenocarcinoma in an elderly patient: A case report. ( 28255431 )
2017
18
Adjuvant chemotherapy versus chemoradiotherapy in the management of patients with surgically resected duodenal adenocarcinoma: A propensity score-matched analysis of a nationwide clinical oncology database. ( 28263387 )
2017
19
Optimal Lymphadenectomy for Duodenal Adenocarcinoma: Does the Number Alone Matter? ( 28799027 )
2017
20
Characteristics and risk factors for sporadic non-ampullary duodenal adenocarcinoma. ( 28830268 )
2017
21
Pathologic Response to Preoperative Therapy as a Novel Prognosticator for Ampullary and Duodenal Adenocarcinoma. ( 28980211 )
2017
22
Accuracy of biopsy for the preoperative diagnosis of superficial nonampullary duodenal adenocarcinoma. ( 28003118 )
2017
23
Clival Metastasis of a Duodenal Adenocarcinoma: A Case Report and Literature Review. ( 28034818 )
2017
24
Stereotactic ablative radiation therapy as a potential curative treatment in duodenal adenocarcinoma: a case report. ( 28218383 )
2017
25
Methylation of MGMT Is Associated with Poor Prognosis in Patients with Stage III Duodenal Adenocarcinoma. ( 27643594 )
2016
26
Duodenal Adenocarcinoma Metastatic to the Breast: A Case Report. ( 26986146 )
2016
27
Whole-exome sequencing of duodenal adenocarcinoma identifies recurrent Wnt/β-catenin signaling pathway mutations. ( 26998897 )
2016
28
Duodenal adenocarcinoma: Advances in diagnosis and surgical management. ( 27022448 )
2016
29
Metastasis of extra-ampullary duodenal adenocarcinoma to the uterine cervix. ( 27126664 )
2016
30
Duodenal Adenocarcinoma Diagnosed from a Biopsy Specimen of a Depressed Lesion Obtained by Magnifying Endoscopy. ( 27403120 )
2016
31
Lymph node evaluation and survival after curative-intent resection of duodenal adenocarcinoma: A matched cohort study. ( 27821316 )
2016
32
Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from China. ( 28116301 )
2016
33
Duodenal adenocarcinoma: A rare cause of chyloperitoneum (chylous ascites). ( 26837993 )
2015
34
Clinicopathological characterisation of duodenal adenocarcinoma with high CD44 variant 9 expression. ( 26517627 )
2015
35
Does the extent of resection impact survival for duodenal adenocarcinoma? Analysis of 1,611 cases. ( 25160736 )
2015
36
Outcome after surgical resection for duodenal adenocarcinoma in the UK. ( 25776995 )
2015
37
Human Epidermal Growth Factor Receptor 2-Positive Duodenal Adenocarcinoma: A Case Report and Review of the Literature. ( 26351435 )
2015
38
S-1 treatment leading to complete remission of advanced duodenal adenocarcinoma: A case report. ( 26623074 )
2015
39
Duodenal Adenocarcinoma: Profile and Predictors of Survival Outcomes. ( 26672582 )
2015
40
Prognosis value of mitotic kinase Aurora-A for primary duodenal adenocarcinoma. ( 24943686 )
2014
41
Duodenal adenocarcinoma following a neuroendocrine tumor in the duodenum. ( 24574838 )
2014
42
Long-term outcomes in patients with duodenal adenocarcinoma. ( 23656271 )
2014
43
Duodenal adenocarcinoma presenting as a mass with aneurismal dilatation. ( 24411203 )
2014
44
Complete response and prolonged disease-free survival in a patient with recurrent duodenal adenocarcinoma treated with bevacizumab plus FOLFOX6. ( 24490045 )
2014
45
Defining the role of adjuvant therapy: ampullary and duodenal adenocarcinoma. ( 24635865 )
2014
46
Duodenal adenocarcinoma in a 10-year-old boy. ( 24647303 )
2014
47
Clinicopathological analysis and survival outcome of duodenal adenocarcinoma. ( 24751389 )
2014
48
Primary Duodenal Adenocarcinoma without Stenosis: A Case Report with a Brief Literature Review. ( 25120470 )
2014
49
Duodenal adenocarcinoma: why the extreme rarity of duodenal bulb primary tumors? ( 25264638 )
2014
50
Wilkie's Syndrome and Left Adnexal Mass: Unusual Presentation of Duodenal Adenocarcinoma. ( 25302201 )
2014

Variations for Duodenum Adenocarcinoma

ClinVar genetic disease variations for Duodenum Adenocarcinoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_001127511.2(APC): c.2504A> G (p.Glu835Gly) single nucleotide variant Uncertain significance rs1554084263 GRCh38 Chromosome 5, 112838152: 112838152
2 APC NM_001127511.2(APC): c.2504A> G (p.Glu835Gly) single nucleotide variant Uncertain significance rs1554084263 GRCh37 Chromosome 5, 112173849: 112173849
3 APC NM_000038.5(APC): c.1984C> A (p.Leu662Ile) single nucleotide variant Uncertain significance rs756859993 GRCh38 Chromosome 5, 112837578: 112837578
4 APC NM_000038.5(APC): c.1984C> A (p.Leu662Ile) single nucleotide variant Uncertain significance rs756859993 GRCh37 Chromosome 5, 112173275: 112173275

Expression for Duodenum Adenocarcinoma

Search GEO for disease gene expression data for Duodenum Adenocarcinoma.

Pathways for Duodenum Adenocarcinoma

GO Terms for Duodenum Adenocarcinoma

Biological processes related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitotic cell cycle checkpoint GO:0007093 9.26 HRAS RAD17
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 HRAS KRAS
3 response to isolation stress GO:0035900 8.96 HRAS KRAS
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.8 HRAS KRAS MUC6

Sources for Duodenum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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