MCID: DDN003
MIFTS: 37

Duodenum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Duodenum Adenocarcinoma

MalaCards integrated aliases for Duodenum Adenocarcinoma:

Name: Duodenum Adenocarcinoma 12 15
Duodenal Adenocarcinoma 12 6 17

Classifications:



External Ids:

Disease Ontology 12 DOID:10816
NCIt 50 C7889
SNOMED-CT 67 408644002
UMLS 70 C0278804

Summaries for Duodenum Adenocarcinoma

Disease Ontology : 12 A duodenum cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Duodenum Adenocarcinoma, also known as duodenal adenocarcinoma, is related to endometrial adenocarcinoma and endometrioid ovary carcinoma. An important gene associated with Duodenum Adenocarcinoma is MIR196A1 (MicroRNA 196a-1), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. Affiliated tissues include colon, lung and ovary, and related phenotypes are Decreased replication of vaccinia virus (VACV) and digestive/alimentary

Related Diseases for Duodenum Adenocarcinoma

Diseases related to Duodenum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 348)
# Related Disease Score Top Affiliating Genes
1 endometrial adenocarcinoma 30.0 MLH1 KRT7 KRAS
2 endometrioid ovary carcinoma 29.7 MSH6 MLH1 KRAS
3 intestinal obstruction 29.6 KRT7 CEACAM5 CDX2
4 papillary adenocarcinoma 29.5 KRT7 KRAS CEACAM5
5 tubular adenocarcinoma 29.5 MUC5AC KRT7 CEACAM5 CDX2
6 familial adenomatous polyposis 29.3 MSH6 MSH2 MLH1 KRAS HRAS
7 gastric adenocarcinoma 29.1 MLH1 KRAS HRAS CEACAM5 CDX2
8 lynch syndrome 29.1 PMS2 MSH6 MSH2 MLH1 KRAS HRAS
9 adenoma 29.0 MUC6 MUC5AC MSH6 MSH2 MLH1 KRT7
10 neurofibromatosis 28.8 PMS2 MSH6 MSH2 MLH1 KRAS HRAS
11 colon adenocarcinoma 28.8 PMS2 MSH6 MLH1 KRAS CEACAM5
12 villous adenoma 28.4 MUC6 MUC5AC MLH1 KRT7 KRAS HRAS
13 adenocarcinoma 28.3 MSH6 MSH2 MLH1 KRT7 KRAS HRAS
14 duodenum cancer 27.9 PMS2 MUC6 MUC5AC MSH6 MSH2 MLH1
15 small intestine cancer 27.2 PMS2 MUC6 MUC5AC MSH6 MSH2 MLH1
16 ovary neuroendocrine neoplasm 10.4 KRT7 CDX2
17 anal canal paget's disease 10.4 KRT7 CDX2
18 gastric signet ring cell adenocarcinoma 10.4 KRT7 CDX2
19 bartholin's gland disease 10.4 KRT7 CDX2
20 bartholin's gland carcinoma 10.4 KRT7 CDX2
21 cystitis cystica 10.4 KRT7 CDX2
22 ovarian seromucinous carcinoma 10.4 KRT7 CDX2
23 rectum neuroendocrine neoplasm 10.4 KRT7 CDX2
24 cervical mucinous adenocarcinoma 10.4 MUC6 KRT7
25 mucinous bronchioloalveolar adenocarcinoma 10.3 KRT7 CDX2
26 ethmoid sinus cancer 10.3 HRAS CDX2
27 spindle cell intraocular melanoma 10.3 PMS2 MLH1
28 jejunal neoplasm 10.3 MUC6 KRT7
29 mucinous stomach adenocarcinoma 10.3 KRT7 CDX2
30 vaginal adenoma 10.3 KRT7 CDX2
31 vaginal benign neoplasm 10.3 KRT7 CDX2
32 thymus clear cell carcinoma 10.3 KRT7 CDX2
33 bladder clear cell adenocarcinoma 10.3 KRT7 CDX2
34 mucinous tubular and spindle renal cell carcinoma 10.3 MUC6 KRT7
35 hepatic flexure cancer 10.3 KRAS HRAS
36 trachea carcinoma in situ 10.3 KRAS HRAS
37 cobblestone retinal degeneration 10.3 KRAS HRAS
38 peritoneal serous adenocarcinoma 10.3 KRT7 CDX2
39 breast neuroendocrine neoplasm 10.3 KRT7 CDX2
40 ampulla of vater benign neoplasm 10.3 KRAS HRAS
41 epididymis adenocarcinoma 10.3 KRT7 CDX2
42 epididymis cancer 10.3 KRT7 CDX2
43 chronic ethmoiditis 10.3 MUC6 MUC5AC
44 meckel diverticulum 10.3 KRT7 CDX2
45 bone giant cell sarcoma 10.3 KRAS HRAS
46 acneiform dermatitis 10.3 KRAS HRAS
47 adenosquamous lung carcinoma 10.3 KRAS HRAS
48 mucinous lung adenocarcinoma 10.3 KRAS HRAS
49 colorectal cancer, hereditary nonpolyposis, type 4 10.3 PMS2 MLH1
50 noonan syndrome-like disorder with loose anagen hair 1 10.3 KRAS HRAS

Graphical network of the top 20 diseases related to Duodenum Adenocarcinoma:



Diseases related to Duodenum Adenocarcinoma

Symptoms & Phenotypes for Duodenum Adenocarcinoma

GenomeRNAi Phenotypes related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased replication of vaccinia virus (VACV) GR00362-A 8.32 KRAS

MGI Mouse Phenotypes related to Duodenum Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CDX2 HRAS KRAS MLH1 MSH2 MUC5AC
2 neoplasm MP:0002006 9.17 CDX2 HRAS KRAS MLH1 MSH2 MSH6

Drugs & Therapeutics for Duodenum Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Duodenum Adenocarcinoma

Genetic Tests for Duodenum Adenocarcinoma

Anatomical Context for Duodenum Adenocarcinoma

MalaCards organs/tissues related to Duodenum Adenocarcinoma:

40
Colon, Lung, Ovary, Pancreas, Small Intestine, Appendix, Breast

Publications for Duodenum Adenocarcinoma

Articles related to Duodenum Adenocarcinoma:

(show top 50) (show all 362)
# Title Authors PMID Year
1
Investigation of patent foramen ovale as a mechanism for brain metastasis in patients without prior lung involvement. 61
32789774 2021
2
Current Oncologic Standards for Surgery of Small Bowel Cancers. 61
33788156 2021
3
Limited resection vs. pancreaticoduodenectomy for primary duodenal adenocarcinoma: a systematic review and meta-analysis. 61
33386555 2021
4
Prognostic factors for overall survival in patients with primary duodenal adenocarcinoma. 61
33549016 2021
5
Simple Versus Radical Resection for Duodenal Adenocarcinoma: A Propensity Score Matched Analysis of National Cancer Database. 61
32927979 2021
6
[A Case of Duodenal Adenocarcinoma in the Third Portion Treated with Partial Duodenectomy]. 61
33597385 2021
7
Nivolumab plus regorafenib in patients with small bowel adenocarcinoma: A case report. 61
33530218 2021
8
Surgical treatment and outcome for primary duodenal adenocarcinoma. Single center experience. 61
33746122 2021
9
Duodenal Adenocarcinoma Mimicking Metastasis of Prostate Cancer on 18F-Prostate-Specific Membrane Antigen-1007 PET/CT. 61
33208620 2021
10
Pancreatic ductal adenocarcinoma and distal cholangiocarcinoma: a proposal of preoperative diagnostic score for differential diagnosis. 61
33430887 2021
11
Time trends in incidence and survival of small intestinal cancer in Sweden. 61
33609370 2021
12
The structure - Activity correlation in the family of dicationic imidazolium surfactants: Antimicrobial properties and cytotoxic effect. 61
32898623 2020
13
Side-to-side duodenojejunostomy after resection of third and fourth duodenal portions with pancreatic preservation. 61
32504267 2020
14
The Role of Neoadjuvant Versus Adjuvant Therapy for Duodenal Adenocarcinoma: A National Cancer Database Propensity Score Matched Analysis. 61
33291951 2020
15
Comparative Analysis of Outcomes and Clinicopathological Characteristics of Duodenal Adenocarcinoma: A SEER Analysis. 61
33073637 2020
16
FOLFIRINOX or FOLFOXIRI in locally advanced duodenal adenocarcinoma: are we missing out? 61
33122352 2020
17
Ten-year impact of pancreaticoduodenectomy on bowel function and quality of life of patients with ileal pouch-anal anastomosis for familial adenomatous polyposis. 61
32019738 2020
18
Immune infiltrating cells in duodenal cancers. 61
32883314 2020
19
Clinicopathological features and risk factors for lymph node metastasis in early-stage non-ampullary duodenal adenocarcinoma. 61
32533301 2020
20
Clinical outcomes of patients with duodenal adenocarcinoma and intestinal-type papilla of Vater adenocarcinoma. 61
32206184 2020
21
[A Case of Primary Duodenal Adenocarcinoma in the Fourth Portion]. 61
32381985 2020
22
[Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells]. 61
32163398 2020
23
Primary Duodenal Adenocarcinoma: Uncommon Tumor, Uncommon Presentation. A Case Report and Review of the Literature. 61
32523384 2020
24
A case report of paraneoplastic syndrome in β-hCG-secreting duodenal adenocarcinoma. 61
31949933 2019
25
Duodenal adenocarcinoma: Surgical results of 27 patients treated at a single center. 61
31563268 2019
26
Does the Artery-first Approach Improve the Rate of R0 Resection in Pancreatoduodenectomy?: A Multicenter, Randomized, Controlled Trial. 61
31498183 2019
27
Mechanical Thrombectomy for Submassive Pulmonary Embolism in an Adult with Duodenal Adenocarcinoma and Brain Metastases. 61
31832290 2019
28
Duodenal Adenocarcinoma at the Ligament of Treitz: Management and Outcome. 61
31633113 2019
29
A pathological complete response by chemotherapy with S-1 and oxaliplatin for a locally advanced duodenal adenocarcinoma in Lynch syndrome: a case report. 61
31637551 2019
30
"Duodenal Adenocarcinoma Giving Rise to Rectal Metastasis" a Rare Disease with an Extremely Rare Metastatic Pattern. 61
29392602 2019
31
Percutaneous stereotactic image-guided microwave ablation for malignant liver lesions. 61
31554853 2019
32
Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis. 61
31423260 2019
33
A case report of three synchronous tumors in the same pancreatic specimen. 61
31341616 2019
34
Molecular alterations and PD-L1 expression in non-ampullary duodenal adenocarcinoma: Associations among clinicopathological, immunophenotypic and molecular features. 61
31324814 2019
35
Durable response for ampullary and duodenal adenocarcinoma with a nab-paclitaxel plus gemcitabine ± cisplatin combination. 61
31102323 2019
36
Functional Expression of Mucin1 in Human Duodenal Adenocarcinoma. 61
30763811 2019
37
Tumour stage and resection margin status are independent survival factors following partial pancreatoduodenectomy for duodenal adenocarcinoma. 61
30972486 2019
38
Assessment of tumor heterogeneity: Differentiation of periampullary neoplasms based on CT whole-lesion histogram analysis. 61
31084752 2019
39
Obstructing Duodenal Diffuse Large B-cell Lymphoma with Peritoneal Lymphomatosis with Exceptional Response to R-CHOP. 61
31312548 2019
40
Endoscopic submucosal dissection of duodenal adenocarcinoma arising from Brunner's gland. 61
31040631 2019
41
Underutilization of Surgery in Periampullary Cancer Treatment. 61
30088190 2019
42
Primary Small Bowel Adenocarcinoma Presenting with Duodenal Stricture and Hepatic and Gastroduodenal Artery Encasement: A Case Report. 61
31263642 2019
43
Synchronous Duodenal Adenocarcinoma and Colon Adenoma Following with Lynch Syndrome Requiring Pancreaticoduodenectomy and Completion Total Colectomy with Ileorectal Anastomosis. 61
32432215 2019
44
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy. 61
30713128 2019
45
Incidence and comparative outcomes of periampullary cancer: A population-based analysis demonstrating improved outcomes and increased use of adjuvant therapy from 2004 to 2012. 61
30561818 2019
46
Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma. 61
31080610 2019
47
A Case of Metastatic Biliary Tract Cancer Diagnosed Through Identification of an IDH1 Mutation. 61
30352944 2019
48
Rare case of small intestine bleeding. 61
30700455 2019
49
A Rare Case of Duodenal Adenocarcinoma Presenting as a Subepithelial Lesion in a Patient Undergoing Investigation for Iron Deficiency Anaemia. 61
31687224 2019
50
Clinicopathological Characteristics, Surgical Treatments, and Survival Outcomes of Patients with Duodenal Gastrointestinal Stromal Tumor. 61
29566369 2019

Variations for Duodenum Adenocarcinoma

ClinVar genetic disease variations for Duodenum Adenocarcinoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 APC NM_000038.6(APC):c.1984C>A (p.Leu662Ile) SNV Uncertain significance 232098 rs756859993 GRCh37: 5:112173275-112173275
GRCh38: 5:112837578-112837578
2 APC NM_000038.6(APC):c.2558A>G (p.Glu853Gly) SNV Uncertain significance 559955 rs1554084263 GRCh37: 5:112173849-112173849
GRCh38: 5:112838152-112838152

Expression for Duodenum Adenocarcinoma

Search GEO for disease gene expression data for Duodenum Adenocarcinoma.

Pathways for Duodenum Adenocarcinoma

Pathways related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1 12.53 MSH6 MSH2 MLH1 KRAS HRAS
2
Show member pathways
12.41 MSH6 MSH2 MLH1 KRAS HRAS
3
Show member pathways
12.25 MSH6 MSH2 MLH1 KRAS HRAS
4
Show member pathways
12.15 MUC6 MUC5AC KRAS HRAS
5 11.74 KRAS HRAS CHN2
6 11.67 MSH6 MSH2 MLH1 KRAS
7 11.41 MSH6 MSH2 MLH1
8
Show member pathways
11.23 PMS2 MSH6 MSH2 MLH1
10 10.57 KRAS HRAS
11 10.39 PMS2 MSH6 MSH2 MLH1

GO Terms for Duodenum Adenocarcinoma

Cellular components related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 PMS2 MLH1
2 MutSalpha complex GO:0032301 8.96 MSH6 MSH2
3 mismatch repair complex GO:0032300 8.92 PMS2 MSH6 MSH2 MLH1

Biological processes related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.62 MUC6 MUC5AC KRAS HRAS
2 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 MSH6 MSH2 MLH1
3 determination of adult lifespan GO:0008340 9.55 MSH6 MSH2
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.54 KRAS HRAS
5 negative regulation of DNA recombination GO:0045910 9.52 MSH6 MSH2
6 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 MSH2 MLH1
7 response to isolation stress GO:0035900 9.49 KRAS HRAS
8 positive regulation of helicase activity GO:0051096 9.48 MSH6 MSH2
9 positive regulation of isotype switching to IgA isotypes GO:0048298 9.46 MSH2 MLH1
10 mismatch repair GO:0006298 9.46 PMS2 MSH6 MSH2 MLH1
11 maintenance of DNA repeat elements GO:0043570 9.43 MSH6 MSH2
12 isotype switching GO:0045190 9.43 MSH6 MSH2 MLH1
13 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MSH2 MLH1
14 somatic recombination of immunoglobulin gene segments GO:0016447 9.13 MSH6 MSH2 MLH1
15 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 PMS2 MSH6 MSH2 MLH1

Molecular functions related to Duodenum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.73 PMS2 MSH6 MSH2 MLH1
2 single-stranded DNA binding GO:0003697 9.63 PMS2 MSH2 MLH1
3 four-way junction DNA binding GO:0000400 9.48 MSH6 MSH2
4 MutSalpha complex binding GO:0032407 9.4 PMS2 MLH1
5 MutLalpha complex binding GO:0032405 9.37 MSH6 MSH2
6 oxidized purine DNA binding GO:0032357 9.32 MSH6 MSH2
7 single guanine insertion binding GO:0032142 9.26 MSH6 MSH2
8 single thymine insertion binding GO:0032143 9.16 MSH6 MSH2
9 guanine/thymine mispair binding GO:0032137 9.13 MSH6 MSH2 MLH1
10 mismatched DNA binding GO:0030983 8.92 PMS2 MSH6 MSH2 MLH1

Sources for Duodenum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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