MCID: DDN022
MIFTS: 23

Duodenum Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Duodenum Adenoma

MalaCards integrated aliases for Duodenum Adenoma:

Name: Duodenum Adenoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050927

Summaries for Duodenum Adenoma

Disease Ontology : 12 A duodenal benign neoplasm that has material basis in epithelial tissue with glandular origin.

MalaCards based summary : Duodenum Adenoma is related to signet ring basal cell carcinoma and pancreas lymphoma. An important gene associated with Duodenum Adenoma is PSMA7 (Proteasome 20S Subunit Alpha 7), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. Affiliated tissues include heart, colon and liver.

Related Diseases for Duodenum Adenoma

Diseases related to Duodenum Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 signet ring basal cell carcinoma 10.3 PTPRC CEACAM5
2 pancreas lymphoma 10.3 PTPRC GPT
3 vulvar apocrine adenocarcinoma 10.3 PTPRC CEACAM5
4 sarcomatous intrahepatic cholangiocarcinoma 10.2 GPT CEACAM5
5 liver inflammatory pseudotumor 10.2 CRP CEACAM5
6 external ear carcinoma 10.2 CRP CEACAM5
7 bile duct cysts 10.2 GPT CEACAM5
8 mediastinal cancer 10.2 PTPRC CEACAM5
9 tuberculous peritonitis 10.2 CRP CEACAM5
10 bicipital tenosynovitis 10.2 PTPRC CRP
11 pericardial tuberculosis 10.2 CRP CEACAM5
12 uvulitis 10.2 GPT CRP
13 emphysematous cholecystitis 10.2 GPT CRP
14 gummatous syphilis 10.2 GPT CRP
15 viral laryngitis 10.2 GPT CRP
16 ankylosing spondylitis 1 10.2 GPT CRP
17 duodenal obstruction 10.2 CRP CEACAM5
18 acalculous cholecystitis 10.2 GPT CRP
19 tinea unguium 10.2 GPT CRP
20 duodenal benign neoplasm 10.2 ZCCHC14 PSMA7 KRR1 APC
21 hydrops of gallbladder 10.2 GPT CRP
22 splenic abscess 10.2 GPT CRP
23 japanese spotted fever 10.2 CRP CCL4L1
24 critical illness polyneuropathy 10.2 GPT CRP
25 ascending cholangitis 10.2 GPT CRP
26 suppurative cholangitis 10.2 GPT CRP
27 lymphangitis 10.2 CRP CEACAM5
28 granulomatous hepatitis 10.2 GPT CRP
29 splenic tuberculosis 10.2 CRP CEACAM5
30 basidiobolomycosis 10.1 GPT CRP
31 gallbladder lymphoma 10.1 PTPRC CEACAM5
32 paralytic ileus 10.1 GPT CRP
33 coronary aneurysm 10.1 GPT CRP
34 lung leiomyosarcoma 10.1 KITLG CEACAM5
35 intrahepatic bile duct adenoma 10.1 GPT CEACAM5
36 heart aneurysm 10.1 GPT CRP
37 splenic infarction 10.1 GPT CRP
38 klatskin's tumor 10.1 GPT CEACAM5
39 pyuria 10.1 GPT CRP
40 t-cell non-hodgkin lymphoma 10.1 PTPRC CCR5
41 pleural empyema 10.1 GPT CRP
42 kwashiorkor 10.1 GPT CRP
43 volvulus of midgut 10.1 GPT CRP
44 gastrointestinal tuberculosis 10.1 GPT CRP CEACAM5
45 large intestine lipoma 10.1 GPT CRP CEACAM5
46 acute cholangitis 10.1 GPT CRP CEACAM5
47 cholecystolithiasis 10.1 GPT CRP CEACAM5
48 lipoma of colon 10.1 GPT CRP CEACAM5
49 common bile duct disease 10.1 GPT CRP CEACAM5
50 bile duct disease 10.1 GPT CRP CEACAM5

Graphical network of the top 20 diseases related to Duodenum Adenoma:



Diseases related to Duodenum Adenoma

Symptoms & Phenotypes for Duodenum Adenoma

Drugs & Therapeutics for Duodenum Adenoma

Search Clinical Trials , NIH Clinical Center for Duodenum Adenoma

Genetic Tests for Duodenum Adenoma

Anatomical Context for Duodenum Adenoma

MalaCards organs/tissues related to Duodenum Adenoma:

40
Heart, Colon, Liver, Lung, Pancreas, Thyroid, Myeloid

Publications for Duodenum Adenoma

Articles related to Duodenum Adenoma:

# Title Authors PMID Year
1
Acute Pancreatitis Caused by Ampullary Duodenum Adenoma in a Patient with Adenomatous Polyposis Coli with Billroth II Reconstruction After Distal Gastrectomy. 61
30552312 2018

Variations for Duodenum Adenoma

Expression for Duodenum Adenoma

Search GEO for disease gene expression data for Duodenum Adenoma.

Pathways for Duodenum Adenoma

Pathways related to Duodenum Adenoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 THPO KITLG CSF1R CCR5 CCR2 CCL4L1
2
Show member pathways
13.15 THPO KITLG CSF1R CCR5 CCR2 CCL4L1
3
Show member pathways
13.06 PSMA7 KITLG FLT3LG CSF1R CCR5 CCR2
4
Show member pathways
12.93 THPO PTPRC KITLG CSF1R CCR5 CCR2
5 12.33 PTPRC KITLG CEACAM5 CCR2
6
Show member pathways
11.89 CSF1R CCR5 CCR2 CCL4L1 CCL4
7
Show member pathways
11.72 CCR5 CCL4L1 CCL4
8 11.48 PTPRC FLT3LG CSF1R
9 11.35 THPO KITLG GYPA FLT3LG CSF1R
10 11.23 CCR5 CCR2 CCL4
11 11.18 KITLG FLT3LG CSF1R
12 11.16 THPO PTPRC KITLG GYPA FLT3LG CEACAM5
13 10.78 THPO KITLG CSF1R CCL4L1 CCL4

GO Terms for Duodenum Adenoma

Cellular components related to Duodenum Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 PTPRC FLT3LG CSF1R CEACAM5 CCR5

Biological processes related to Duodenum Adenoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.88 PTPRC PSMA7 GYPA CCR5 CCR2
2 MAPK cascade GO:0000165 9.76 PSMA7 KITLG FLT3LG CCR5
3 cytokine-mediated signaling pathway GO:0019221 9.72 FLT3LG CSF1R CCR5 CCR2 CCL4
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.55 THPO PTPRC CSF1R CCL4L1 CCL4
5 eosinophil chemotaxis GO:0048245 9.52 CCL4L1 CCL4
6 embryonic hemopoiesis GO:0035162 9.51 KITLG FLT3LG
7 dendritic cell chemotaxis GO:0002407 9.49 CCR5 CCR2
8 positive regulation of alpha-beta T cell proliferation GO:0046641 9.43 PTPRC CCR2
9 inflammatory response GO:0006954 9.43 CSF1R CRP CCR5 CCR2 CCL4L1 CCL4
10 positive regulation of hematopoietic stem cell proliferation GO:1902035 9.4 THPO KITLG
11 regulation of interleukin-8 production GO:0032677 9.37 PTPRC CRP
12 positive regulation of hematopoietic stem cell migration GO:2000473 9.26 PTPRC CCR2
13 chemokine-mediated signaling pathway GO:0070098 8.92 CCR5 CCR2 CCL4L1 CCL4

Molecular functions related to Duodenum Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 PSMA7 GYPA CRP CEACAM5 CCR5 CCR2
2 cytokine activity GO:0005125 8.92 THPO KITLG FLT3LG CCL4

Sources for Duodenum Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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