Aliases & Classifications for Duodenum Disease

MalaCards integrated aliases for Duodenum Disease:

Name: Duodenum Disease 12 15
Duodenal Diseases 54 44 70
Abnormality of the Duodenum 6
Duodenum Disorder 12
Duodenal Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4072
MeSH 44 D004378
SNOMED-CT 67 196598004
UMLS 70 C0013289

Summaries for Duodenum Disease

MalaCards based summary : Duodenum Disease, also known as duodenal diseases, is related to duodenitis and duodenal ulcer, and has symptoms including constipation and diarrhea. An important gene associated with Duodenum Disease is S100A8 (S100 Calcium Binding Protein A8), and among its related pathways/superpathways are Gastric cancer and Salivary secretion. The drug Pharmaceutical Solutions has been mentioned in the context of this disorder. Affiliated tissues include small intestine and pancreas, and related phenotypes are Reduced mammosphere formation and digestive/alimentary

Wikipedia : 73 The duodenum is the first section of the small intestine in most higher vertebrates, including mammals,... more...

Related Diseases for Duodenum Disease

Diseases related to Duodenum Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 408)
# Related Disease Score Top Affiliating Genes
1 duodenitis 30.2 S100A8 GAST ATP4A ATP12A
2 duodenal ulcer 30.2 SST SCT S100A8 GAST
3 gastroduodenitis 30.2 GAST ATP4A ATP12A
4 hernia, hiatus 30.1 GAST ATP4A ATP12A
5 gastric lymphoma 30.1 S100A8 ATP4A ATP12A
6 gastric ulcer 30.1 SST S100A8 GAST
7 dumping syndrome 30.1 SST SCT GAST
8 cholecystitis 30.1 S100A8 MUC6 MUC5AC MUC1
9 multiple endocrine neoplasia 30.0 SST SCT MEN1 GAST
10 peptic esophagitis 29.9 S100A8 GAST CDX2 ATP4A ATP12A
11 duodenal obstruction 29.8 SCT CEACAM5 ATP4A ATP12A
12 duodenogastric reflux 29.8 SST SCT GAST ATP4A ATP12A
13 gastritis 29.8 SST SCT S100A8 MUC6 GAST CDX2
14 atrophic gastritis 29.7 SST S100A8 MUC6 MEN1 GAST CDX2
15 zollinger-ellison syndrome 29.6 SST SCT MEN1 GAST ATP4A ATP12A
16 familial adenomatous polyposis 29.6 SMAD4 MUTYH MLH1 KRAS HRAS
17 multiple endocrine neoplasia, type i 29.6 SST SCT PPY MEN1 GAST
18 peptic ulcer disease 29.4 SST SCT S100A8 MUC5AC MEN1 HRAS
19 gastric adenocarcinoma 29.1 SMAD4 S100A8 MLH1 KRAS HRAS GAST
20 duodenum cancer 26.9 SST SMAD4 SCT PPY MUTYH MUC6
21 vagus nerve disease 10.4 ATP4A ATP12A
22 ovary neuroendocrine neoplasm 10.4 KRT7 CDX2
23 necrotizing gastritis 10.4 ATP4A ATP12A
24 scalp dermatosis 10.4 ATP4A ATP12A
25 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
26 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
27 lingual goiter 10.4 ATP4A ATP12A
28 bacterial esophagitis 10.4 ATP4A ATP12A
29 cascade stomach 10.4 ATP4A ATP12A
30 anal canal paget's disease 10.4 KRT7 CDX2
31 benzylpenicillin allergy 10.4 ATP4A ATP12A
32 gastric signet ring cell adenocarcinoma 10.4 KRT7 CDX2
33 median arcuate ligament syndrome 10.4 ATP4A ATP12A
34 afferent loop syndrome 10.4 ATP4A ATP12A
35 cervix erosion 10.4 ATP4A ATP12A
36 angiodysplasia of intestine 10.4 ATP4A ATP12A
37 laryngeal tuberculosis 10.4 ATP4A ATP12A
38 fungal esophagitis 10.4 ATP4A ATP12A
39 dieulafoy lesion 10.4 ATP4A ATP12A
40 cefuroxime allergy 10.4 ATP4A ATP12A
41 bartholin's gland disease 10.4 KRT7 CDX2
42 emphysematous cholecystitis 10.4 ATP4A ATP12A
43 bartholin's gland carcinoma 10.4 KRT7 CDX2
44 pancreatic serous cystic neoplasm 10.4 S100A8 MUC6
45 thymic neuroendocrine tumor 10.4 MEN1 HRAS
46 superior mesenteric artery syndrome 10.4 ATP4A ATP12A
47 pneumatosis cystoides intestinalis 10.4 ATP4A ATP12A
48 cystitis cystica 10.4 KRT7 CDX2
49 chronic laryngitis 10.4 ATP4A ATP12A
50 ovarian seromucinous carcinoma 10.4 KRT7 CDX2

Graphical network of the top 20 diseases related to Duodenum Disease:



Diseases related to Duodenum Disease

Symptoms & Phenotypes for Duodenum Disease

UMLS symptoms related to Duodenum Disease:


constipation; diarrhea

GenomeRNAi Phenotypes related to Duodenum Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 ATP4A HRAS KRAS KRT7 MEN1 MUC5AC

MGI Mouse Phenotypes related to Duodenum Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 ATP12A ATP4A CDX2 GAST HRAS KRAS
2 neoplasm MP:0002006 9.28 ATP4A CDX2 GAST HRAS KRAS MEN1

Drugs & Therapeutics for Duodenum Disease

Drugs for Duodenum Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Innate Response to and Changes in Intestinal Permeability 4 Hours After a Gluten Challenge in Subjects With Celiac Disease and Non Celiac Gluten Sensitivity Completed NCT03288831
2 A Correlation of the Endoscopic Characteristics of Duodenal and Ampullary Laterally Spreading Tumours With Their Somatic or Germline Mutations. Recruiting NCT01556399
3 Transnasal and Conventional Oral Diagnostic Gastroscopy. A Prospective Randomised Study. Terminated NCT00273117

Search NIH Clinical Center for Duodenum Disease

Cochrane evidence based reviews: duodenal diseases

Genetic Tests for Duodenum Disease

Anatomical Context for Duodenum Disease

MalaCards organs/tissues related to Duodenum Disease:

40
Small Intestine, Pancreas

Publications for Duodenum Disease

Articles related to Duodenum Disease:

(show top 50) (show all 157)
# Title Authors PMID Year
1
[cagA,vacA and iceA genotypes of Helicobacter pylori isolated from children in Shanghai]. 54 61
20416217 2010
2
[Genotypic study on the Helicobacter pylori vacA, cagA and iceA genes in the infected children in Guangzhou area]. 54 61
18021567 2007
3
Helicobacter pylori infection in children and adults: a single pathogen but a different pathology. 61 54
12603613 2003
4
Clinical comparative analysis of various duodenal diseases in different age groups. 61
32897221 2020
5
Comparison of Helicobacter pylori Detection Methods: It's Association with Leukocytosis and Monocytosis. 61
32634084 2020
6
Methotrexate-associated lymphoproliferative disorder in the stomach and duodenum: a case report. 61
31023238 2019
7
Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases. 61
30509760 2018
8
Imaging of non-neoplastic duodenal diseases. A pictorial review with emphasis on MDCT. 61
29388052 2018
9
Update on the management of Helicobacter pylori infection. Position paper from the Catalan Society of Digestology. 61
29426621 2018
10
The influence of vitamin D deficiency on eradication rates of Helicobacter pylori. 61
29442458 2017
11
Genetic characterization of Helicobacter pylori vacA and cagA genes in Thai gastro-duodenal and hepatobiliary patients. 61
28141589 2017
12
Imaging spectrum of nonneoplastic duodenal diseases. 61
27572283 2016
13
Functional profile of gastric epithelial cells infected with Helicobacter pylori strains. 61
27015934 2016
14
To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases. 61
25780285 2015
15
Magnified endoscopic features of duodenal follicular lymphoma and other whitish lesions. 61
25703169 2015
16
Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia. 61
25503415 2014
17
Helicobacter pylori: the balance between a role as colonizer and pathogen. 61
25439068 2014
18
Natural products and food components with anti-Helicobacter pylori activities. 61
25083070 2014
19
[Molecular-pathological analysis of Helicobacter pylori-associated disorders and clinical laboratory testing]. 61
25051658 2014
20
Antibacterial activity of a novel synthetic progesterone species carrying a linoleic acid molecule against Helicobacter pylori and the hormonal effect of its steroid on a murine macrophage-like cell line. 61
24189541 2014
21
[Primary coloduodenal fistula]. 61
24369408 2013
22
cagE as a biomarker of the pathogenicity of Helicobacter pylori. 61
23740068 2013
23
Helicobacter pylori: molecular detection of vacA gene and vacuolating activity in human gastric adenocarcinoma cells. 61
24045512 2013
24
Association of genetic polymorphisms in IL17A and IL17F with gastro-duodenal diseases. 61
23012664 2012
25
[The role of a workflow in diagnosing biliary causes for acute pancreatitis]. 61
22490809 2012
26
Association of Helicobacter pylori infection and gastric carcinoma. 61
22314459 2012
27
[Polymorphism of Helicobacter pylori vacA, isolated in China]. 61
21781481 2011
28
Helicobacter pylori induces activation of human peripheral γδ+ T lymphocytes. 61
21559446 2011
29
Stable surface expression of a gene for Helicobacter pylori toxic porin protein with pBAD expression system. 61
19662358 2009
30
Proteomic and functional characterization of the outer membrane vesicles from the gastric pathogen Helicobacter pylori. 61
21136987 2009
31
Effect of RANTES promoter genotype on the severity of intestinal metaplasia in Helicobacter pylori-infected Japanese subjects. 61
18958622 2009
32
GastroPanel: evaluation of the usefulness in the diagnosis of gastro-duodenal mucosal alterations in children. 61
19135434 2009
33
[Genetic type of Helicobacter pylori and the efficacy of eradication therapy]. 61
19388513 2009
34
Association of Helicobacter pylori restriction endonuclease-replacing gene, hrgA with overt gastrointestinal diseases. 61
18852951 2008
35
Toll-like receptor 2 (TLR) -196 to 174del polymorphism in gastro-duodenal diseases in Japanese population. 61
17934843 2008
36
Hiccups as a myocardial ischemia symptom. 61
18476462 2008
37
A simple multiplex PCR assay for diagnosing virulent Helicobacter pylori infection in human gastric biopsy specimens from subjects with gastric carcinoma and other gastro-duodenal diseases. 61
17850305 2007
38
Effect of fluoxetine on depression-induced changes in the expression of vasoactive intestinal polypeptide and corticotrophin releasing factor in rat duodenum. 61
18023100 2007
39
Anomalous opening of the common bile duct into the duodenal bulb: endoscopic treatment. 61
17610747 2007
40
[Relationship between the types of Helicobacter pylori strains and chronic upper gastrointestinal diseases in children]. 61
17582254 2007
41
[Relationship between iceA1, iceA2 and babA2 genes of Hp in Xi'an and gastroduodenal diseases]. 61
17553347 2007
42
[The clinical effectiveness of rabeprazole in patients with acid-related gastric and duodenal diseases with various sensitivity of different types of parietal gastric cell receptors]. 61
17523409 2007
43
[Gastric and duodenal peptic ulcer in automobile drivers: prevalence, clinical features and prophylaxis]. 61
17354599 2007
44
Gastroduodenal diseases of childhood. 61
17053441 2006
45
CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model. 61
16933206 2006
46
The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. 61
18039108 2006
47
NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection. 61
16273640 2005
48
[Frequency of Helicobacter pylori infection in patients with different clinical symptoms]. 61
16541715 2005
49
[Imaging of the stomach and the duodenum]. 61
15184795 2004
50
Illness experience before and after an initiative to identify, treat, and prevent Helicobacter pylori-related diseases in the workplace. 61
15091284 2004

Variations for Duodenum Disease

ClinVar genetic disease variations for Duodenum Disease:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 overlap with 22 genes GRCh37/hg19 17q12(chr17:34437475-36243028) copy number gain Pathogenic 997073 GRCh37: 17:34437475-36243028
GRCh38:

Expression for Duodenum Disease

Search GEO for disease gene expression data for Duodenum Disease.

Pathways for Duodenum Disease

GO Terms for Duodenum Disease

Cellular components related to Duodenum Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 SST SCT S100A8 PPY MUC6 MUC5AC
2 extracellular space GO:0005615 9.28 SST SCT S100A8 PPY MUC6 MUC5AC

Biological processes related to Duodenum Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP4A ATP12A
2 response to transforming growth factor beta GO:0071559 9.26 SMAD4 MEN1
3 response to isolation stress GO:0035900 9.16 KRAS HRAS
4 O-glycan processing GO:0016266 9.13 MUC6 MUC5AC MUC1
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 MUC6 MUC5AC MUC1 KRAS HRAS

Molecular functions related to Duodenum Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP4A ATP12A
2 MutSalpha complex binding GO:0032407 9.26 MUTYH MLH1
3 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
5 hormone activity GO:0005179 8.92 SST SCT PPY GAST

Sources for Duodenum Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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