MCID: DPY001
MIFTS: 51

Dupuytren Contracture

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Dupuytren Contracture

MalaCards integrated aliases for Dupuytren Contracture:

Name: Dupuytren Contracture 57 25 73
Dupuytren Contracture 1 57 13 73
Dupuytren's Contracture 76 25
Contraction of Palmar Fascia 25
Familial Palmar Fibromatosis 25
Palmar Fascial Fibromatosis 25
Dupuytren Disease 25
Palmar Fibromas 25

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
onset in fifth or sixth decade
earlier onset is associated with more aggressive disease course
male to female ratio is greater than 3:1
reduced penetrance
progressive disorder
high risk of recurrence after surgery
associated with trauma and impaired wound repair (alcoholism, diabetes, substance abuse, liver disease)


HPO:

32
dupuytren contracture:
Inheritance autosomal dominant inheritance
Onset and clinical course adult onset progressive incomplete penetrance


Classifications:



Summaries for Dupuytren Contracture

OMIM : 57 Dupuytren contracture is the most common heritable disorder of connective tissue. It is a disease of the soft tissues of the palm and fingers characterized by a progressive thickening and shortening of the fascial structures that normally provide support to the glabrous skin of the palm. Although it can also be a sporadic disorder, the inherited form is most frequently observed among people of Nordic descent. There is a male: female ratio of greater than 3:1 (Hu et al., 2005). Dupuytren contracture has been associated with multiple fibroproliferative conditions, including Peyronie disease (171000), knuckle pads (149100), congenital generalized fibromatosis (228550), juvenile fibromatosis (228600), and frozen shoulder, suggesting a common underlying defect in wound repair (Hu et al., 2005). (126900)

MalaCards based summary : Dupuytren Contracture, also known as dupuytren contracture 1, is related to carpal tunnel syndrome and familial dupuytren contracture. An important gene associated with Dupuytren Contracture is DUPC1 (Dupuytren Contracture 1), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Menthol and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include skin and liver, and related phenotypes are dupuytren contracture and joint contracture of the hand

Genetics Home Reference : 25 Dupuytren contracture is a deformity of the hand in which the joints of one or more fingers cannot be fully straightened (extended); their mobility is limited to a range of bent (flexed) positions. These joint problems generally get worse over time.

Wikipedia : 76 Dupuytren\'s contracture is a condition in which one or more fingers become permanently bent in a flexed... more...

Related Diseases for Dupuytren Contracture

Diseases in the Dupuytren Contracture family:

Familial Dupuytren Contracture

Diseases related to Dupuytren Contracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 carpal tunnel syndrome 30.4 IL1B TGFB1 VEGFA
2 familial dupuytren contracture 12.1
3 ledderhose disease 11.1
4 penile disease 10.7 DCN TGFB1
5 cholecystolithiasis 10.7 BMP6 TGFB1
6 fibromatosis, gingival, 1 10.7 SERPINH1 TGFB1
7 tuberculoid leprosy 10.6 BMP6 TGFB1
8 funisitis 10.6 IL1B SERPINH1
9 poems syndrome 10.5 IL1B VEGFA
10 chronic myocardial ischemia 10.5 FGF2 VEGFA
11 melorheostosis 10.5 BMP6 FGF2
12 angiodysplasia 10.5 FGF2 VEGFA
13 radiation proctitis 10.4 FGF2 VEGFA
14 microcystic meningioma 10.4 TIMP2 VEGFA
15 hypertrophic scars 10.4 BMP6 TGFB1
16 adenomyosis 10.4 TIMP2 VEGFA
17 vaginal disease 10.4 IL1B SERPINH1
18 lipodermatosclerosis 10.4 TIMP2 VEGFA
19 epulis 10.3 DES NGFR
20 female reproductive system disease 10.3 IL1B SERPINH1 VEGFA
21 preterm premature rupture of the membranes 10.3 SERPINH1 TIMP2
22 juvenile nasopharyngeal angiofibroma 10.3 BMP6 FGF2 VEGFA
23 aortic aneurysm, familial abdominal, 1 10.3 DCN IL1B TIMP2
24 laryngitis 10.2 FGF2 IL1B TGFB1
25 idiopathic hypercalciuria 10.2 BMP6 FGF2 IL1B
26 endometrial disease 10.2 IL1B SERPINH1
27 keratitis, hereditary 10.2 FGF2 IL1B VEGFA
28 corneal neovascularization 10.1 FGF2 TIMP2 VEGFA
29 crouzon syndrome 10.0 BMP6 DCN FGF2 TGFB1
30 odontogenic myxoma 10.0 DCN VEGFA
31 immunodeficiency-centromeric instability-facial anomalies syndrome 1 9.9
32 paine syndrome 9.9
33 mononeuropathy of the median nerve, mild 9.9
34 peyronie's disease 9.9
35 complex regional pain syndrome 9.9
36 connective tissue disease 9.9
37 spindle cell sarcoma 9.9 DES VEGFA
38 fibrosarcoma 9.8 DES FGF2 TIMP2
39 de quervain disease 9.7
40 pulmonary fibrosis, idiopathic 9.6 BMP6 FGF2 IL1B SERPINH1 TGFB1
41 ewing sarcoma 9.3 DES FGF2 IL1B TGFB1 VEGFA
42 vascular disease 9.2 BMP6 FGF2 VEGFA XDH

Graphical network of the top 20 diseases related to Dupuytren Contracture:



Diseases related to Dupuytren Contracture

Symptoms & Phenotypes for Dupuytren Contracture

Symptoms via clinical synopsis from OMIM:

57
Skeletal Hands:
contractures of the fingers (especially fifth finger)

Muscle Soft Tissue:
thickening of the fascial structures of the palm and fingers
shortening of the fascial structures of the palm and fingers
plantar fibromatosis


Clinical features from OMIM:

126900

Human phenotypes related to Dupuytren Contracture:

32
# Description HPO Frequency HPO Source Accession
1 dupuytren contracture 32 HP:0005679
2 joint contracture of the hand 32 HP:0009473

MGI Mouse Phenotypes related to Dupuytren Contracture:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 COL15A1 DES FBLN1 FGF2 IL1B NGFR
2 mortality/aging MP:0010768 10.02 FGF2 IL1B NGFR SERPINH1 TGFB1 VEGFA
3 craniofacial MP:0005382 9.95 DCN FBLN1 IL1B NGFR SERPINH1 TGFB1
4 integument MP:0010771 9.91 DCN FBLN1 IL1B NGFR TGFB1 VEGFA
5 muscle MP:0005369 9.86 COL15A1 DCN DES FGF2 NGFR TGFB1
6 renal/urinary system MP:0005367 9.63 DCN FBLN1 NGFR TGFB1 VEGFA XDH
7 respiratory system MP:0005388 9.43 SERPINH1 TGFB1 VEGFA DCN FBLN1 NGFR
8 skeleton MP:0005390 9.28 IL1B NGFR SERPINH1 TGFB1 VEGFA BMP6

Drugs & Therapeutics for Dupuytren Contracture

Drugs for Dupuytren Contracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4 2216-51-5 16666
2 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
3 Anesthetics, Local Phase 4,Phase 3,Phase 2
4
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
5
Petrolatum Approved, Investigational Phase 2, Phase 3 8009-03-8
6
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
7 Calcium, Dietary Phase 3
8 Anti-Inflammatory Agents Phase 3,Phase 2
9 glucocorticoids Phase 3
10 Hormone Antagonists Phase 3
11 Hormones Phase 3
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
13 Immunosuppressive Agents Phase 3
14 Retinol palmitate Phase 3
15 triamcinolone acetonide Phase 3
16 Triamcinolone diacetate Phase 3
17 Triamcinolone hexacetonide Phase 3
18 Anesthetics, General Phase 3
19 retinol Nutraceutical Phase 3
20
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
21
Adalimumab Approved Phase 2 331731-18-1 16219006
22
Acetaminophen Approved Phase 2 103-90-2 1983
23
Ibuprofen Approved Phase 2 15687-27-1 3672
24
Oxycodone Approved, Illicit, Investigational Phase 2 76-42-6 5284603
25 Central Nervous System Depressants Phase 2
26 Peripheral Nervous System Agents Phase 2
27 Antirheumatic Agents Phase 2
28 Analgesics Phase 2
29 Analgesics, Non-Narcotic Phase 2
30 Analgesics, Opioid Phase 2
31 Anti-Inflammatory Agents, Non-Steroidal Phase 2
32 Antipyretics Phase 2
33 Cyclooxygenase Inhibitors Phase 2
34 Narcotics Phase 2
35 Opiate Alkaloids Phase 2

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Xiaflex Injection for Treatment of Dupuytren's Contracture of the Thumb Completed NCT01265420 Phase 4
2 MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex Completed NCT01450397 Phase 4
3 Retreatment of Recurrent Dupuytren's Contractures Completed NCT01498640 Phase 4
4 Trial Comparing Treatment Strategies in Dupuytren's Contracture Recruiting NCT03192020 Phase 4 Collagenase Clostridium Histolyticum 2.9 MG/ML [Xiaflex]
5 Prospective Randomized Trial Between Needle Fasciotomy and Xiapex for Dupuytrens Contracture Recruiting NCT02476461 Phase 4 xiapex
6 Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren's Disease Recruiting NCT03000114 Phase 4 XIAFLEX
7 Dupuytren´s Disease Study. Primary Disease, MCP Joint, Xiapex, PNF Active, not recruiting NCT02647619 Phase 4 Xiapex
8 Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease Enrolling by invitation NCT03406338 Phase 4 Collagenase Clostridium Histolyticum
9 Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture Terminated NCT01226121 Phase 4
10 Collagenase Option for Reduction of Dupuytren's Contracture in Japan Completed NCT01588353 Phase 3 Collagenase Clostridium Histolyticum
11 Administration of Two Injections for Multiple Dupuytren's Contractures Completed NCT01407068 Phase 3
12 Safety and Efficacy of Two Concurrent Injections of AA4500 in Adult Subjects With Multiple Dupuytren's Contractures Completed NCT01674634 Phase 3
13 AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren's Contracture Completed NCT00528606 Phase 3
14 Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture Completed NCT00565019 Phase 3 Triamcinolone Acetonide
15 Treatment Of Dupuytren's Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex) Completed NCT01229436 Phase 3 Xiapex
16 Evaluation of the Efficiency of Autologous Platelet Gel (Platelet Rich Fibrin) Obtained From Own Patients' Blood Versus Vaselitulle in Dupuytren's Disease Postoperative Wound Healing Completed NCT00931567 Phase 2, Phase 3
17 Collagenase in the Treatment of Dupuytrens Disease Completed NCT00260429 Phase 3
18 Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease Completed NCT00014742 Phase 3 collagenase
19 Safety and Efficacy Study of AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease Completed NCT00528840 Phase 3
20 AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease Completed NCT00528424 Phase 3
21 Non-US Study of AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease Completed NCT00533273 Phase 3
22 Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren's Recruiting NCT02725528 Phase 3 collagenase injection
23 Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease Withdrawn NCT01776892 Phase 3 Collegenase injection
24 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
25 Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease Completed NCT00004409 Phase 2 collagenase
26 Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules Completed NCT02193828 Phase 2
27 Liposome Bupivacaine for WRIST Blocks Recruiting NCT03106519 Phase 2 Liposome bupivacaine + bupivacaine
28 Repurposing Anti-TNF for Treating Dupuytren's Disease Recruiting NCT03180957 Phase 2 Adalimumab;Saline
29 Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery Not yet recruiting NCT03111186 Phase 2 Oxycodone Hcl 5Mg;Ibuprofen 400 mg;Acetaminophen 650 mg
30 A Pharmacokinetic Study of AA4500 (XIAFLEX™, Proposed Name) in Subjects With Dupuytren's Contracture Completed NCT00528931 Phase 1
31 Knee Stiffness in Fibrosis Diathesis Unknown status NCT02294890
32 Validation of Two New Questionnaires for Dupuytren's Disease Unknown status NCT01446432
33 Stiffness of the Skin and Joints in Relation to Carpal Tunnel Syndrome Unknown status NCT01081860
34 CORRECT: COmmunity RegistRy Study Evaluating Dupuytren's Contracture Treatment Completed NCT01715467
35 Injectable Collagenase and Percutaneous Needle Fasciotomy for Dupuytren's Contracture Completed NCT01538017 Not Applicable Xiapex
36 Post Approval Commitment Study Completed NCT01444729 Xiapex
37 Registry of Dupuytren's Contracture Treatment Outcomes Completed NCT01567397
38 Splinting for Dupuytren's Contracture Release Completed NCT00575458
39 Health-Related Quality of Life in Patients With Dupuytren's Disease Completed NCT00468949
40 Registry of Patient With M. Dupuytren and Validation of the Brief MHQ Completed NCT01876498
41 Longterm Observational Study in Subjects Treated With AA4500 in AUX-CC-854, 856, 857, 858 & 859 Completed NCT00954746
42 Epidemiology and Outcomes of Upper Limb Surgery: Analysis of Routine Data Completed NCT03573765
43 Hand Therapy or Not Following Collagenase Treatment for Dupuytren's Contracture? Recruiting NCT03580213 Not Applicable
44 The Effects of Prophylactic Limited Palmar Fasciectomy on Surgical Outcomes and Scarring Recruiting NCT03155854 Not Applicable
45 Short-term Function and Pain After Treatment for Dupuytren's Disease Recruiting NCT02301078 Collagenase clostridium histolyticum
46 Different Sutures in Hand Surgery Recruiting NCT03407820 Not Applicable
47 BOND Study: the Benefit Of Night Splinting in Dupuytrens' Active, not recruiting NCT03031080 Not Applicable
48 Collagenase is a Common Treatment of MCP and PIP Joint Contractures in Dupuytrens Disease Active, not recruiting NCT03331926 Xiapex
49 Natural Disease Progress of Dupuytren Disease Active, not recruiting NCT01923103
50 Percutaneous Aponeurotomy in the Treatment of Dupuytren's Disease Active, not recruiting NCT02474576 Not Applicable

Search NIH Clinical Center for Dupuytren Contracture

Genetic Tests for Dupuytren Contracture

Anatomical Context for Dupuytren Contracture

MalaCards organs/tissues related to Dupuytren Contracture:

41
Skin, Liver

Publications for Dupuytren Contracture

Articles related to Dupuytren Contracture:

(show all 37)
# Title Authors Year
1
Dupuytren Disease: Is Collagenase Better Than Needling?: Commentary on an article by Joakim StrAPmberg, MD, et al.: "Percutaneous Needle Fasciotomy Versus Collagenase Treatment for Dupuytren Contracture. A Randomized Controlled Trial with a Two-Year Follow-up". ( 29975278 )
2018
2
Percutaneous Needle Fasciotomy Versus Collagenase Treatment for Dupuytren Contracture: A Randomized Controlled Trial with a Two-Year Follow-up. ( 29975270 )
2018
3
The Incidence of Complex Regional Pain Syndrome in Simultaneous Surgical Treatment of Carpal Tunnel Syndrome and Dupuytren Contracture. ( 28691512 )
2017
4
Pain Associated With Treatment of Dupuytren Contracture With Collagenase Clostridium histolyticum. ( 28160905 )
2017
5
Injectable Collagenase Versus Percutaneous Needle Fasciotomy for Dupuytren Contracture in Proximal Interphalangeal Joints: AA Randomized Controlled Trial. ( 28473158 )
2017
6
Prevalence of Peyronie's Disease-Like Symptoms in Men Presenting With Dupuytren Contractures. ( 28676223 )
2017
7
Complications Following Collagenase Treatment for Dupuytren Contracture. ( 28635316 )
2017
8
Modified McCash Technique for Management of Dupuytren Contracture. ( 28259564 )
2017
9
Treatment of Recurrent Dupuytren Contracture in Joints Previously Effectively Treated With Collagenase Clostridium histolyticum. ( 28341067 )
2017
10
Needle aponeurotomy for Dupuytren contracture: Effectiveness of postoperative night extension splinting. ( 27054134 )
2016
11
Comparison of Treatment Outcome After Collagenase and Needle Fasciotomy for Dupuytren Contracture: A Randomized, Single-Blinded, Clinical Trial With a 1-Year Follow-Up. ( 27473921 )
2016
12
Treatment of Dupuytren Contracture With Injectable Collagenase Within the Veterans Affairs System. ( 27760243 )
2016
13
The "Bowstring Arch Bridge" Analogy to Guide Sequential Portal Placement during Needle Aponeurotomy in the Treatment of Dupuytren Contracture. ( 27999467 )
2016
14
Measurement Properties of the Brief Michigan Hand Outcomes Questionnaire in Patients With Dupuytren Contracture. ( 27469936 )
2016
15
Collagenase Dupuytren Contracture: Achieving Single Treatment Success with a Hand Therapist-Based Protocol. ( 27014558 )
2016
16
Letter Regarding "Dupuytren Contracture Recurrence Following Treatment With Collagenase Clostridium Histolyticum (CORDLESS [Collagenase Option for Reduction of Dupuytren Long-Term Evaluation of Safety Study]): 5-Year Data". ( 26518325 )
2015
17
Connective tissue diseases: Blood vessel microenvironment sustains cell renewal in Dupuytren contracture nodules. ( 26077921 )
2015
18
Efficacy and safety of collagenase clostridium histolyticum in the treatment of proximal interphalangeal joints in dupuytren contracture: combined analysis of 4 phase 3 clinical trials. ( 25843533 )
2015
19
Management of complications of Dupuytren contracture. ( 25934208 )
2015
20
Collagenase enzymatic fasciotomy for Dupuytren contracture in patients on chronic immunosuppression. ( 26566553 )
2015
21
Dupuytren Contracture Recurrence Following Treatment With Collagenase Clostridium histolyticum (CORDLESS [Collagenase Option for Reduction of Dupuytren Long-Term Evaluation of Safety Study]): 5-Year Data. ( 26096221 )
2015
22
Delayed manipulation after collagenase clostridium histolyticum injection for Dupuytren contracture. ( 26330801 )
2015
23
Percutaneous Aponeurotomy and Lipofilling (PALF): A Regenerative Approach to Dupuytren Contracture. ( 26116943 )
2015
24
Contemporary management of dupuytren contracture. ( 24720301 )
2014
25
Evidence-based medicine: Dupuytren contracture. ( 24776555 )
2014
26
Prospective randomized controlled trial comparing 1- versus 7-day manipulation following collagenase injection for dupuytren contracture. ( 25194768 )
2014
27
Technical tips for collagenase injection treatment for Dupuytren contracture. ( 24862115 )
2014
28
Cold intolerance following collagenase Clostridium histolyticum treatment for Dupuytren contracture: a molecular mechanism. ( 25154579 )
2014
29
Analysis of efficacy and safety of treatment with collagenase Clostridium histolyticum among subgroups of patients with Dupuytren contracture. ( 23511746 )
2014
30
Cold intolerance following collagenase Clostridium histolyticum treatment for Dupuytren contracture. ( 24679915 )
2014
31
Dupuytren contracture recurrence project: reaching consensus on a definition of recurrence. ( 25412239 )
2014
32
Hand function and quality of life before and after fasciectomy for Dupuytren contracture. ( 24969497 )
2014
33
The effect of night extension orthoses following surgical release of Dupuytren contracture: a single-center, randomized, controlled trial. ( 23790420 )
2013
34
Imiquimod: a potential weapon against Dupuytren contracture. ( 16368197 )
2006
35
[Preoperative intermittent pneumatic extension treatment stage III and IV Dupuytren contracture]. ( 10763127 )
2000
36
Cytogenetic and interphase cytogenetic analyses reveal chromosome instability but no clonal trisomy 8 in Dupuytren contracture. ( 9352799 )
1997
37
[2-stage operative treatment of Dupuytren contracture]. ( 4007639 )
1985

Variations for Dupuytren Contracture

Expression for Dupuytren Contracture

Search GEO for disease gene expression data for Dupuytren Contracture.

Pathways for Dupuytren Contracture

Pathways related to Dupuytren Contracture according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 BMP6 COL15A1 DES FGF2 IL1B NGFR
2
Show member pathways
13.33 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
3
Show member pathways
13.24 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
4
Show member pathways
13.14 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
5
Show member pathways
12.89 BMP6 FGF2 NGFR TGFB1 TIMP2
6
Show member pathways
12.86 BMP6 COL15A1 FGF2 NGFR TGFB1 TIMP2
7 12.59 FGF2 IL1B NGFR TGFB1 VEGFA
8
Show member pathways
12.35 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
9
Show member pathways
12.15 COL15A1 DCN FBLN1 FGF2 SERPINH1 TGFB1
10 12.11 DCN FGF2 TGFB1 VEGFA
11 11.86 IL1B NGFR TGFB1
12 11.86 FGF2 NGFR TGFB1 VEGFA
13 11.76 IL1B TGFB1 VEGFA
14 11.76 FGF2 IL1B TGFB1 VEGFA
15 11.71 IL1B TGFB1 VEGFA
16 11.7 FGF2 TGFB1 TIMP2
17 11.67 BMP6 DCN TGFB1
18
Show member pathways
11.65 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
19 11.51 FGF2 IL1B TGFB1
20 11.34 FGF2 TGFB1 VEGFA
21 11.31 FGF2 TGFB1 VEGFA
22 11.02 IL1B TIMP2
23 10.96 FGF2 TGFB1 VEGFA
24 10.88 FGF2 TIMP2 VEGFA
25 10.83 BMP6 FGF2 SERPINH1 TGFB1 VEGFA

GO Terms for Dupuytren Contracture

Cellular components related to Dupuytren Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 BMP6 COL15A1 DCN FBLN1 FGF2 IL1B
2 extracellular matrix GO:0031012 9.55 COL15A1 DCN FBLN1 TGFB1 TIMP2
3 secretory granule GO:0030141 9.43 IL1B TGFB1 VEGFA
4 extracellular space GO:0005615 9.36 BMP6 COL15A1 DCN FBLN1 FGF2 IL1B

Biological processes related to Dupuytren Contracture according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.91 BMP6 IL1B NGFR TGFB1
2 positive regulation of cell proliferation GO:0008284 9.88 BMP6 FGF2 IL1B TGFB1 VEGFA
3 positive regulation of angiogenesis GO:0045766 9.79 FGF2 IL1B VEGFA
4 kidney development GO:0001822 9.73 BMP6 DCN VEGFA
5 regulation of signaling receptor activity GO:0010469 9.72 BMP6 FGF2 IL1B TGFB1 VEGFA
6 wound healing GO:0042060 9.7 DCN FGF2 TGFB1
7 cellular response to mechanical stimulus GO:0071260 9.69 BMP6 IL1B TGFB1
8 positive regulation of vascular endothelial growth factor production GO:0010575 9.64 IL1B TGFB1
9 positive regulation of sprouting angiogenesis GO:1903672 9.64 FGF2 VEGFA
10 positive regulation of protein localization to nucleus GO:1900182 9.63 NGFR TGFB1
11 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.63 NGFR TGFB1
12 negative regulation of protein phosphorylation GO:0001933 9.63 FBLN1 TGFB1 XDH
13 positive regulation of protein complex assembly GO:0031334 9.62 TGFB1 VEGFA
14 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 TGFB1 VEGFA
15 positive regulation of endothelial cell proliferation GO:0001938 9.61 BMP6 FGF2 VEGFA
16 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.6 IL1B VEGFA
17 membrane protein intracellular domain proteolysis GO:0031293 9.59 NGFR TGFB1
18 positive regulation of histone acetylation GO:0035066 9.58 IL1B TGFB1
19 hyaluronan catabolic process GO:0030214 9.58 FGF2 TGFB1
20 positive regulation of MAP kinase activity GO:0043406 9.58 FGF2 TGFB1 VEGFA
21 cell migration involved in sprouting angiogenesis GO:0002042 9.57 FGF2 VEGFA
22 cytokine-mediated signaling pathway GO:0019221 9.55 DCN FGF2 IL1B TGFB1 VEGFA
23 positive regulation of SMAD protein signal transduction GO:0060391 9.54 BMP6 TGFB1
24 positive regulation of epithelial cell proliferation GO:0050679 9.54 BMP6 TGFB1 VEGFA
25 negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 9.49 DCN XDH
26 positive regulation of blood vessel endothelial cell migration GO:0043536 9.43 FGF2 TGFB1 VEGFA
27 positive regulation of p38MAPK cascade GO:1900745 9.13 IL1B VEGFA XDH
28 positive regulation of cell division GO:0051781 8.92 FGF2 IL1B TGFB1 VEGFA
29 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 BMP6 DCN FGF2 IL1B TGFB1 VEGFA

Molecular functions related to Dupuytren Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.43 FGF2 IL1B TIMP2
2 fibronectin binding GO:0001968 9.32 FBLN1 VEGFA
3 growth factor activity GO:0008083 9.26 BMP6 FGF2 TGFB1 VEGFA
4 BMP receptor binding GO:0070700 9.16 BMP6 TGFB1
5 cytokine activity GO:0005125 9.02 BMP6 FGF2 IL1B TGFB1 VEGFA

Sources for Dupuytren Contracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....