MCID: DPY001
MIFTS: 53

Dupuytren Contracture

Categories: Genetic diseases, Rare diseases, Skin diseases

Aliases & Classifications for Dupuytren Contracture

MalaCards integrated aliases for Dupuytren Contracture:

Name: Dupuytren Contracture 58 26 17 74
Dupuytren Contracture 1 58 13 74
Dupuytren's Contracture 77 26
Contraction of Palmar Fascia 26
Familial Palmar Fibromatosis 26
Palmar Fascial Fibromatosis 26
Dupuytren Disease 26
Palmar Fibromas 26

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
progressive disorder
onset in fifth or sixth decade
earlier onset is associated with more aggressive disease course
male to female ratio is greater than 3:1
reduced penetrance
high risk of recurrence after surgery
associated with trauma and impaired wound repair (alcoholism, diabetes, substance abuse, liver disease)


HPO:

33
dupuytren contracture:
Onset and clinical course adult onset incomplete penetrance progressive
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Dupuytren Contracture

OMIM : 58 Dupuytren contracture is the most common heritable disorder of connective tissue. It is a disease of the soft tissues of the palm and fingers characterized by a progressive thickening and shortening of the fascial structures that normally provide support to the glabrous skin of the palm. Although it can also be a sporadic disorder, the inherited form is most frequently observed among people of Nordic descent. There is a male: female ratio of greater than 3:1 (Hu et al., 2005). Dupuytren contracture has been associated with multiple fibroproliferative conditions, including Peyronie disease (171000), knuckle pads (149100), congenital generalized fibromatosis (228550), juvenile fibromatosis (228600), and frozen shoulder, suggesting a common underlying defect in wound repair (Hu et al., 2005). (126900)

MalaCards based summary : Dupuytren Contracture, also known as dupuytren contracture 1, is related to carpal tunnel syndrome and familial dupuytren contracture. An important gene associated with Dupuytren Contracture is DUPC1 (Dupuytren Contracture 1), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Anesthetics and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include skin and liver, and related phenotypes are joint contracture of the hand and dupuytren contracture

Genetics Home Reference : 26 Dupuytren contracture is a deformity of the hand in which the joints of one or more fingers cannot be fully straightened (extended); their mobility is limited to a range of bent (flexed) positions. These joint problems generally get worse over time.

Wikipedia : 77 Dupuytren''s contracture is a condition in which one or more fingers become permanently bent in a flexed... more...

Related Diseases for Dupuytren Contracture

Diseases in the Dupuytren Contracture family:

Familial Dupuytren Contracture

Diseases related to Dupuytren Contracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 carpal tunnel syndrome 30.3 VEGFA TGFB1 IL1B
2 familial dupuytren contracture 12.3
3 plantar fascial fibromatosis 11.3
4 ledderhose disease 11.3
5 tenosynovitis 10.3
6 cholecystolithiasis 10.3 BMP6 TGFB1
7 fibromatosis 10.3
8 tuberculoid leprosy 10.2 BMP6 TGFB1
9 cataract 10.2
10 keloids 10.2
11 laryngitis 10.2 TGFB1 IL1B FGF2
12 autoimmune gastritis 10.2 IL1B TGFB1
13 gingival overgrowth 10.2 TGFB1 FGF2 DCN
14 fibromatosis, gingival, 1 10.2 SERPINH1 TGFB1
15 kashin-beck disease 10.2 IL1B VEGFA
16 epulis 10.2 DES NGFR
17 idiopathic hypercalciuria 10.2 IL1B FGF2 BMP6
18 hypertrophic scars 10.1 BMP6 TGFB1
19 mononeuropathy of the median nerve, mild 10.1
20 peyronie's disease 10.1
21 complex regional pain syndrome 10.1
22 connective tissue disease 10.1
23 chronic myocardial ischemia 10.1 FGF2 VEGFA
24 angiodysplasia 10.1 FGF2 VEGFA
25 radiation proctitis 10.1 FGF2 VEGFA
26 epidermoid cysts 10.1
27 knuckle pads 10.1
28 eosinophilic fasciitis 10.1
29 pulmonary alveolar microlithiasis 10.1
30 psoriatic arthritis 10.1
31 arthritis 10.1
32 hepatitis 10.1
33 liver disease 10.1
34 thrombocytopenia 10.1
35 endocarditis 10.1
36 gout 10.1
37 polyneuropathy 10.1
38 neuritis 10.1
39 enthesopathy 10.1
40 periarthritis 10.1
41 ischemia 10.1
42 mammary paget's disease 10.1
43 vasculitis 10.1
44 psoriasis 10.1
45 fasciitis 10.1
46 osteonecrosis of the jaw 10.1 TGFB1 VEGFA
47 nonspecific interstitial pneumonia 10.0 TGFB1 SERPINH1 FGF2
48 crouzon syndrome 10.0 TGFB1 FGF2 DCN BMP6
49 poems syndrome 10.0 VEGFA IL1B FGF2
50 respiratory system disease 10.0 VEGFA TGFB1 IL1B

Graphical network of the top 20 diseases related to Dupuytren Contracture:



Diseases related to Dupuytren Contracture

Symptoms & Phenotypes for Dupuytren Contracture

Human phenotypes related to Dupuytren Contracture:

33
# Description HPO Frequency HPO Source Accession
1 joint contracture of the hand 33 HP:0009473
2 dupuytren contracture 33 HP:0005679

Symptoms via clinical synopsis from OMIM:

58
Skeletal Hands:
contractures of the fingers (especially fifth finger)

Muscle Soft Tissue:
thickening of the fascial structures of the palm and fingers
shortening of the fascial structures of the palm and fingers
plantar fibromatosis

Clinical features from OMIM:

126900

MGI Mouse Phenotypes related to Dupuytren Contracture:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 COL15A1 DES FBLN1 FGF2 IL1B NGFR
2 mortality/aging MP:0010768 10.02 DCN DES FBLN1 FGF2 IL1B NGFR
3 craniofacial MP:0005382 9.95 DCN FBLN1 IL1B NGFR SERPINH1 TGFB1
4 integument MP:0010771 9.91 DCN FBLN1 IL1B NGFR TGFB1 VEGFA
5 muscle MP:0005369 9.91 COL15A1 DCN DES FBLN1 FGF2 NGFR
6 renal/urinary system MP:0005367 9.63 DCN FBLN1 NGFR TGFB1 VEGFA XDH
7 respiratory system MP:0005388 9.43 DCN FBLN1 NGFR SERPINH1 TGFB1 VEGFA
8 skeleton MP:0005390 9.28 BMP6 DCN FBLN1 FGF2 IL1B NGFR

Drugs & Therapeutics for Dupuytren Contracture

Drugs for Dupuytren Contracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
2 Anesthetics, Local Phase 4,Phase 3,Phase 2
3
Triamcinolone Approved, Vet_approved Phase 3,Phase 1 124-94-7 31307
4
Petrolatum Approved, Investigational Phase 2, Phase 3 8009-03-8
5
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
6
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
7 Calcium, Dietary Phase 3
8 glucocorticoids Phase 3,Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
10 triamcinolone acetonide Phase 3,Phase 1
11 Hormone Antagonists Phase 3,Phase 1
12 Immunologic Factors Phase 3,Phase 1
13 Triamcinolone diacetate Phase 3,Phase 1
14 Immunosuppressive Agents Phase 3,Phase 1
15 Hormones Phase 3,Phase 1
16 retinol Phase 3
17 Triamcinolone hexacetonide Phase 3,Phase 1
18 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
19 Retinol palmitate Phase 3
20 Anesthetics, General Phase 3
21
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
22
Acetaminophen Approved Phase 2 103-90-2 1983
23
Oxycodone Approved, Illicit, Investigational Phase 2 76-42-6 5284603
24
Ibuprofen Approved Phase 2 15687-27-1 3672
25
Adalimumab Approved Phase 2 331731-18-1 16219006
26 Central Nervous System Depressants Phase 2,Not Applicable
27 Peripheral Nervous System Agents Phase 2
28 Analgesics, Opioid Phase 2
29 Narcotics Phase 2
30 Anti-Inflammatory Agents, Non-Steroidal Phase 2
31 Antipyretics Phase 2
32 Cyclooxygenase Inhibitors Phase 2
33 Opiate Alkaloids Phase 2
34 Antirheumatic Agents Phase 2
35 Analgesics, Non-Narcotic Phase 2
36 Analgesics Phase 2,Not Applicable
37
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
38
tannic acid Approved Not Applicable 1401-55-4

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Trial Comparing Treatment Strategies in Dupuytren's Contracture Recruiting NCT03192020 Phase 4 Collagenase Clostridium Histolyticum 2.9 MG/ML [Xiaflex]
2 Efficacy and Safety of Xiaflex Injection for Treatment of Dupuytren's Contracture of the Thumb Completed NCT01265420 Phase 4
3 Prospective Randomized Trial Between Needle Fasciotomy and Xiapex for Dupuytrens Contracture Recruiting NCT02476461 Phase 4 xiapex
4 MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex Completed NCT01450397 Phase 4
5 Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture Terminated NCT01226121 Phase 4
6 Retreatment of Recurrent Dupuytren's Contractures Completed NCT01498640 Phase 4
7 Dupuytren´s Disease Study. Primary Disease, MCP Joint, Xiapex, PNF Active, not recruiting NCT02647619 Phase 4 Xiapex
8 Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren's Disease Recruiting NCT03000114 Phase 4 XIAFLEX
9 Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease Enrolling by invitation NCT03406338 Phase 4 Collagenase Clostridium Histolyticum
10 Collagenase Option for Reduction of Dupuytren's Contracture in Japan Completed NCT01588353 Phase 3 Collagenase Clostridium Histolyticum
11 Administration of Two Injections for Multiple Dupuytren's Contractures Completed NCT01407068 Phase 3
12 Safety and Efficacy of Two Concurrent Injections of AA4500 in Adult Subjects With Multiple Dupuytren's Contractures Completed NCT01674634 Phase 3
13 AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Dupuytren's Contracture Completed NCT00528606 Phase 3
14 Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture Completed NCT00565019 Phase 3 Triamcinolone Acetonide
15 Treatment Of Dupuytren's Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex) Completed NCT01229436 Phase 3 Xiapex
16 Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease Withdrawn NCT01776892 Phase 3 Collegenase injection
17 Evaluation of the Efficiency of Autologous Platelet Gel (Platelet Rich Fibrin) Obtained From Own Patients' Blood Versus Vaselitulle in Dupuytren's Disease Postoperative Wound Healing Completed NCT00931567 Phase 2, Phase 3
18 Collagenase in the Treatment of Dupuytrens Disease Completed NCT00260429 Phase 3
19 Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease Completed NCT00014742 Phase 3 collagenase
20 Safety and Efficacy Study of AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease Completed NCT00528840 Phase 3
21 AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease Completed NCT00528424 Phase 3
22 Non-US Study of AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease Completed NCT00533273 Phase 3
23 Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren's Recruiting NCT02725528 Phase 3 collagenase injection
24 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
25 Liposome Bupivacaine for WRIST Blocks Recruiting NCT03106519 Phase 2 Liposome bupivacaine + bupivacaine
26 Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease Completed NCT00004409 Phase 2 collagenase
27 Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery Not yet recruiting NCT03111186 Phase 2 Oxycodone Hcl 5Mg;Ibuprofen 400 mg;Acetaminophen 650 mg
28 Repurposing Anti-TNF for Treating Dupuytren's Disease Recruiting NCT03180957 Phase 2 Adalimumab;Saline
29 Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules Completed NCT02193828 Phase 2
30 A Pharmacokinetic Study of AA4500 (XIAFLEX™, Proposed Name) in Subjects With Dupuytren's Contracture Completed NCT00528931 Phase 1
31 A Pilot Study of Intralesional Injection of Triamcinolone Acetonide for Desmoid Tumors Recruiting NCT03627741 Phase 1 Triamcinolone Acetonide
32 Knee Stiffness in Fibrosis Diathesis Unknown status NCT02294890
33 Validation of Two New Questionnaires for Dupuytren's Disease Unknown status NCT01446432
34 Short-term Function and Pain After Treatment for Dupuytren's Disease Unknown status NCT02301078 Collagenase clostridium histolyticum
35 Stiffness of the Skin and Joints in Relation to Carpal Tunnel Syndrome Unknown status NCT01081860
36 CORRECT: COmmunity RegistRy Study Evaluating Dupuytren's Contracture Treatment Completed NCT01715467
37 Hand Therapy or Not Following Collagenase Treatment for Dupuytren's Contracture? Recruiting NCT03580213 Not Applicable
38 Injectable Collagenase and Percutaneous Needle Fasciotomy for Dupuytren's Contracture Completed NCT01538017 Not Applicable Xiapex
39 Post Approval Commitment Study Completed NCT01444729 Xiapex
40 BOND Study: the Benefit Of Night Splinting in Dupuytrens' Active, not recruiting NCT03031080 Not Applicable
41 The Effects of Prophylactic Limited Palmar Fasciectomy on Surgical Outcomes and Scarring Recruiting NCT03155854 Not Applicable
42 Registry of Dupuytren's Contracture Treatment Outcomes Completed NCT01567397
43 Splinting for Dupuytren's Contracture Release Completed NCT00575458
44 Health-Related Quality of Life in Patients With Dupuytren's Disease Completed NCT00468949
45 Collagenase is a Common Treatment of MCP and PIP Joint Contractures in Dupuytrens Disease Active, not recruiting NCT03331926 Xiapex
46 Is wGRS Associated With DD Recurrence? Active, not recruiting NCT02983162
47 Treatment of Dupuytren's Disease With Minimal Invasive Surgery and VIVOSORB® Resorbable Implant Device Not yet recruiting NCT03741764 Not Applicable
48 Natural Disease Progress of Dupuytren Disease Active, not recruiting NCT01923103
49 Registry of Patient With M. Dupuytren and Validation of the Brief MHQ Completed NCT01876498
50 Longterm Observational Study in Subjects Treated With AA4500 in AUX-CC-854, 856, 857, 858 & 859 Completed NCT00954746

Search NIH Clinical Center for Dupuytren Contracture

Genetic Tests for Dupuytren Contracture

Anatomical Context for Dupuytren Contracture

MalaCards organs/tissues related to Dupuytren Contracture:

42
Skin, Liver

Publications for Dupuytren Contracture

Articles related to Dupuytren Contracture:

(show top 50) (show all 73)
# Title Authors Year
1
Dupuytren Disease: Is Collagenase Better Than Needling?: Commentary on an article by Joakim StrAPmberg, MD, et al.: "Percutaneous Needle Fasciotomy Versus Collagenase Treatment for Dupuytren Contracture. A Randomized Controlled Trial with a Two-Year Follow-up". ( 29975278 )
2018
2
Percutaneous Needle Fasciotomy Versus Collagenase Treatment for Dupuytren Contracture: A Randomized Controlled Trial with a Two-Year Follow-up. ( 29975270 )
2018
3
Fasciectomy for Dupuytren Contracture. ( 30012295 )
2018
4
Ultrasound Features of Palmar Fibromatosis or Dupuytren Contracture. ( 30027660 )
2018
5
A post hoc analysis of Dupuytren contracture treated with collagenase Clostridium histolyticum across disease stages. ( 30039732 )
2018
6
Collagenase Clostridium Histolyticum Injection with Precise Needle Length Adjusted by Silicone Tube Interposition for Dupuytren Contracture. ( 30282547 )
2018
7
The Incidence of Complex Regional Pain Syndrome in Simultaneous Surgical Treatment of Carpal Tunnel Syndrome and Dupuytren Contracture. ( 28691512 )
2017
8
Pain Associated With Treatment of Dupuytren Contracture With Collagenase Clostridium histolyticum. ( 28160905 )
2017
9
Injectable Collagenase Versus Percutaneous Needle Fasciotomy for Dupuytren Contracture in Proximal Interphalangeal Joints: AA Randomized Controlled Trial. ( 28473158 )
2017
10
Complications Following Collagenase Treatment for Dupuytren Contracture. ( 28635316 )
2017
11
Modified McCash Technique for Management of Dupuytren Contracture. ( 28259564 )
2017
12
Treatment of Recurrent Dupuytren Contracture in Joints Previously Effectively Treated With Collagenase Clostridium histolyticum. ( 28341067 )
2017
13
Needle aponeurotomy for Dupuytren contracture: Effectiveness of postoperative night extension splinting. ( 27054134 )
2016
14
Comparison of Treatment Outcome After Collagenase and Needle Fasciotomy for Dupuytren Contracture: A Randomized, Single-Blinded, Clinical Trial With a 1-Year Follow-Up. ( 27473921 )
2016
15
Treatment of Dupuytren Contracture With Injectable Collagenase Within the Veterans Affairs System. ( 27760243 )
2016
16
The "Bowstring Arch Bridge" Analogy to Guide Sequential Portal Placement during Needle Aponeurotomy in the Treatment of Dupuytren Contracture. ( 27999467 )
2016
17
Measurement Properties of the Brief Michigan Hand Outcomes Questionnaire in Patients With Dupuytren Contracture. ( 27469936 )
2016
18
Collagenase Dupuytren Contracture: Achieving Single Treatment Success with a Hand Therapist-Based Protocol. ( 27014558 )
2016
19
Letter Regarding "Dupuytren Contracture Recurrence Following Treatment With Collagenase Clostridium Histolyticum (CORDLESS [Collagenase Option for Reduction of Dupuytren Long-Term Evaluation of Safety Study]): 5-Year Data". ( 26518325 )
2015
20
Connective tissue diseases: Blood vessel microenvironment sustains cell renewal in Dupuytren contracture nodules. ( 26077921 )
2015
21
Efficacy and safety of collagenase clostridium histolyticum in the treatment of proximal interphalangeal joints in dupuytren contracture: combined analysis of 4 phase 3 clinical trials. ( 25843533 )
2015
22
Management of complications of Dupuytren contracture. ( 25934208 )
2015
23
Collagenase enzymatic fasciotomy for Dupuytren contracture in patients on chronic immunosuppression. ( 26566553 )
2015
24
Dupuytren Contracture Recurrence Following Treatment With Collagenase Clostridium histolyticum (CORDLESS [Collagenase Option for Reduction of Dupuytren Long-Term Evaluation of Safety Study]): 5-Year Data. ( 26096221 )
2015
25
Delayed manipulation after collagenase clostridium histolyticum injection for Dupuytren contracture. ( 26330801 )
2015
26
Percutaneous Aponeurotomy and Lipofilling (PALF): A Regenerative Approach to Dupuytren Contracture. ( 26116943 )
2015
27
Dupuytren contracture in the pediatric population: a systematic review. ( 24163199 )
2015
28
Contemporary management of dupuytren contracture. ( 24720301 )
2014
29
Evidence-based medicine: Dupuytren contracture. ( 24776555 )
2014
30
Prospective randomized controlled trial comparing 1- versus 7-day manipulation following collagenase injection for dupuytren contracture. ( 25194768 )
2014
31
Technical tips for collagenase injection treatment for Dupuytren contracture. ( 24862115 )
2014
32
Cold intolerance following collagenase Clostridium histolyticum treatment for Dupuytren contracture: a molecular mechanism. ( 25154579 )
2014
33
Analysis of efficacy and safety of treatment with collagenase Clostridium histolyticum among subgroups of patients with Dupuytren contracture. ( 23511746 )
2014
34
Cold intolerance following collagenase Clostridium histolyticum treatment for Dupuytren contracture. ( 24679915 )
2014
35
Dupuytren contracture recurrence project: reaching consensus on a definition of recurrence. ( 25412239 )
2014
36
Hand function and quality of life before and after fasciectomy for Dupuytren contracture. ( 24969497 )
2014
37
Efficacy and safety of collagenase Clostridium histolyticum injection for Dupuytren contracture: report of 40 cases. ( 24254968 )
2014
38
The effect of night extension orthoses following surgical release of Dupuytren contracture: a single-center, randomized, controlled trial. ( 23790420 )
2013
39
Dupuytren contracture recurrence following treatment with collagenase clostridium histolyticum (CORDLESS study): 3-year data. ( 23200951 )
2013
40
Efficacy and safety of collagenase clostridium histolyticum injection for Dupuytren contracture: short-term results from 2 open-label studies. ( 23218556 )
2013
41
Skin graft loss resulting from collagenase clostridium histolyticum treatment of Dupuytren contracture: case report and review of the literature. ( 23391354 )
2013
42
Cost comparison of open fasciectomy versus percutaneous needle aponeurotomy for treatment of Dupuytren contracture. ( 23486126 )
2013
43
Collagenase for recurrent dupuytren contracture with skin grafts. ( 23707028 )
2013
44
Collagenase clostridium histolyticum for dupuytren contracture: patterns of use and effectiveness in clinical practice. ( 24140362 )
2013
45
Injectable Collagenase for the Treatment of Dupuytren Contracture: A Critical Analysis Review. ( 27490506 )
2013
46
Skin laceration as a serious adverse sequela of injectable collagenase for Dupuytren contracture. ( 22186568 )
2012
47
Cost of open partial fasciectomy, needle aponeurotomy, and collagenase injection for dupuytren contracture. ( 22281175 )
2012
48
Results of needle aponeurotomy for Dupuytren contracture in over 1,000 fingers. ( 22464232 )
2012
49
Partial improvement of Dupuytren contracture following a wasp sting. ( 22541160 )
2012
50
German version of the brief Michigan Hand Outcomes Questionnaire: implications for early quality of life following collagenase injection in dupuytren contracture. ( 22544146 )
2012

Variations for Dupuytren Contracture

Expression for Dupuytren Contracture

Search GEO for disease gene expression data for Dupuytren Contracture.

Pathways for Dupuytren Contracture

Pathways related to Dupuytren Contracture according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 BMP6 COL15A1 DES FGF2 IL1B NGFR
2
Show member pathways
13.39 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
3
Show member pathways
13.26 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
4
Show member pathways
13.16 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
5
Show member pathways
12.91 BMP6 FGF2 NGFR TGFB1 TIMP2
6
Show member pathways
12.88 BMP6 COL15A1 FGF2 NGFR TGFB1 TIMP2
7 12.61 FGF2 IL1B NGFR TGFB1 VEGFA
8
Show member pathways
12.47 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
9
Show member pathways
12.15 COL15A1 DCN FBLN1 FGF2 SERPINH1 TGFB1
10 12.14 DCN FGF2 TGFB1 VEGFA
11
Show member pathways
11.94 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
12 11.9 FGF2 NGFR TGFB1 VEGFA
13 11.88 IL1B NGFR TGFB1
14 11.81 FGF2 IL1B TGFB1 VEGFA
15
Show member pathways
11.81 BMP6 FGF2 IL1B NGFR TGFB1 TIMP2
16 11.78 IL1B TGFB1 VEGFA
17 11.73 IL1B TGFB1 VEGFA
18 11.71 FGF2 TGFB1 TIMP2
19 11.71 BMP6 DCN TGFB1
20 11.59 BMP6 FGF2 TGFB1 TIMP2
21 11.53 FGF2 IL1B TGFB1
22 11.39 FGF2 TGFB1 VEGFA
23 11.35 FGF2 TGFB1 VEGFA
24 11.04 IL1B TIMP2
25 11.02 FGF2 TGFB1 VEGFA
26 10.96 FGF2 NGFR VEGFA
27 10.96 FGF2 TIMP2 VEGFA
28 10.83 BMP6 FGF2 SERPINH1 TGFB1 VEGFA
29 10.6 BMP6 COL15A1 DES FGF2 IL1B TGFB1

GO Terms for Dupuytren Contracture

Cellular components related to Dupuytren Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.73 COL15A1 DCN FBLN1 TGFB1 TIMP2 VEGFA
2 extracellular region GO:0005576 9.7 BMP6 COL15A1 DCN FBLN1 FGF2 IL1B
3 collagen-containing extracellular matrix GO:0062023 9.63 COL15A1 DCN FBLN1 SERPINH1 TGFB1 TIMP2
4 secretory granule GO:0030141 9.5 IL1B TGFB1 VEGFA
5 extracellular space GO:0005615 9.36 BMP6 COL15A1 DCN FBLN1 FGF2 IL1B

Biological processes related to Dupuytren Contracture according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.89 BMP6 FGF2 IL1B TGFB1 VEGFA
2 cytokine-mediated signaling pathway GO:0019221 9.83 FGF2 IL1B TGFB1 VEGFA
3 positive regulation of angiogenesis GO:0045766 9.8 FGF2 IL1B VEGFA
4 kidney development GO:0001822 9.75 BMP6 DCN VEGFA
5 regulation of signaling receptor activity GO:0010469 9.72 BMP6 FGF2 IL1B TGFB1 VEGFA
6 cellular response to mechanical stimulus GO:0071260 9.69 BMP6 IL1B TGFB1
7 extracellular matrix organization GO:0030198 9.67 COL15A1 DCN FBLN1 FGF2
8 negative regulation of protein phosphorylation GO:0001933 9.65 FBLN1 TGFB1 XDH
9 positive regulation of vascular endothelial growth factor production GO:0010575 9.64 IL1B TGFB1
10 positive regulation of protein complex assembly GO:0031334 9.64 TGFB1 VEGFA
11 positive regulation of protein localization to nucleus GO:1900182 9.63 NGFR TGFB1
12 positive regulation of endothelial cell proliferation GO:0001938 9.63 BMP6 FGF2 VEGFA
13 cell migration involved in sprouting angiogenesis GO:0002042 9.62 FGF2 VEGFA
14 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 TGFB1 VEGFA
15 positive regulation of epithelial cell proliferation GO:0050679 9.61 BMP6 TGFB1 VEGFA
16 positive regulation of histone acetylation GO:0035066 9.6 IL1B TGFB1
17 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.59 IL1B VEGFA
18 hyaluronan catabolic process GO:0030214 9.58 FGF2 TGFB1
19 positive regulation of MAP kinase activity GO:0043406 9.58 FGF2 TGFB1 VEGFA
20 membrane protein intracellular domain proteolysis GO:0031293 9.57 NGFR TGFB1
21 negative regulation of vascular endothelial growth factor signaling pathway GO:1900747 9.56 DCN XDH
22 positive regulation of SMAD protein signal transduction GO:0060391 9.54 BMP6 TGFB1
23 positive regulation of blood vessel endothelial cell migration GO:0043536 9.43 FGF2 TGFB1 VEGFA
24 response to immobilization stress GO:0035902 9.33 TGFB1
25 positive regulation of p38MAPK cascade GO:1900745 9.33 IL1B VEGFA XDH
26 response to vitamin D GO:0033280 9.31 TGFB1
27 wound healing GO:0042060 9.13 DCN FGF2 TGFB1
28 positive regulation of cell division GO:0051781 8.92 FGF2 IL1B TGFB1 VEGFA
29 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 BMP6 DCN FGF2 IL1B TGFB1 VEGFA

Molecular functions related to Dupuytren Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.33 FGF2 IL1B TIMP2
2 growth factor activity GO:0008083 9.26 BMP6 FGF2 TGFB1 VEGFA
3 cytokine activity GO:0005125 9.02 BMP6 FGF2 IL1B TGFB1 VEGFA

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