MCID: DYS013
MIFTS: 34

Dysbaric Osteonecrosis

Categories: Bone diseases

Aliases & Classifications for Dysbaric Osteonecrosis

MalaCards integrated aliases for Dysbaric Osteonecrosis:

Name: Dysbaric Osteonecrosis 12 15 73
Caisson Disease of Bone 12
Don 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080018
UMLS 73 C3494941

Summaries for Dysbaric Osteonecrosis

Disease Ontology : 12 An ischemic bone disease the has material basis in nitrogen embolization located in bone.

MalaCards based summary : Dysbaric Osteonecrosis, also known as caisson disease of bone, is related to osteonecrosis and conversion disorder. An important gene associated with Dysbaric Osteonecrosis is ECI1 (Enoyl-CoA Delta Isomerase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include bone and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Dysbaric osteonecrosis or DON is a form of avascular necrosis where there is death of a portion of the... more...

Related Diseases for Dysbaric Osteonecrosis

Diseases related to Dysbaric Osteonecrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 10.9
2 conversion disorder 10.6 ALX3 COMT
3 leukodystrophy, hypomyelinating, 3 10.6 APOA1 APOB
4 hyperlipidemia, familial combined 10.6 APOA1 APOB
5 hypobetalipoproteinemia, familial, 1 10.5 APOA1 APOB
6 ischemic heart disease 10.5 APOA1 APOB
7 hypolipoproteinemia 10.5 APOA1 APOB
8 fetal macrosomia 10.5 APOA1 APOB
9 vitamin e, familial isolated deficiency of 10.4 APOA1 APOB
10 chylomicron retention disease 10.4 APOA1 APOB
11 hypoalphalipoproteinemia, primary 10.4 APOA1 APOB
12 hypertriglyceridemia, familial 10.4 APOA1 APOB
13 hyperlipoproteinemia, type iii 10.3 APOA1 APOB
14 arcus corneae 10.3 APOA1 APOB
15 ascaridiasis 10.1 PLG STH
16 catastrophic antiphospholipid syndrome 10.1 F3 SERPINE1
17 carotid artery thrombosis 10.1 F3 SERPINE1
18 angina pectoris 10.0 F3 SERPINE1
19 bone disease 10.0
20 hyperlipoproteinemia, type iv 10.0 APOA1 APOB SERPINE1
21 factor xiii deficiency 10.0 F3 SERPINE1
22 coronary stenosis 10.0 APOA1 APOB SERPINE1
23 coronary heart disease 1 10.0 APOA1 APOB SERPINE1
24 familial hyperlipidemia 10.0 APOA1 APOB SERPINE1
25 lipid metabolism disorder 10.0 APOA1 APOB SERPINE1
26 atherosclerosis susceptibility 10.0 APOA1 APOB SERPINE1
27 coronary thrombosis 10.0 F3 SERPINE1
28 cerebrovascular disease 10.0 APOA1 APOB SERPINE1
29 hyperalphalipoproteinemia 1 10.0 APOA1 APOB
30 shwartzman phenomenon 10.0 F3 SERPINE1
31 tuberculous empyema 9.8 PLG SERPINE1
32 acute cor pulmonale 9.8 PLG SERPINE1
33 acute pulmonary heart disease 9.8 PLG SERPINE1
34 conjugate gaze palsy 9.8 F3 PLG
35 intestinal impaction 9.7 F3 PLG
36 afibrinogenemia, congenital 9.7 C3 F3
37 leech infestation 9.7 F3 PLG
38 giant hemangioma 9.7 F3 PLG
39 intracranial embolism 9.7 F3 PLG
40 intracranial hypertension 9.7 F3 SERPINE1
41 femoral neuropathy 9.7 F3 PLG
42 korean hemorrhagic fever 9.7 F3 PLG
43 vertebral artery occlusion 9.7 F3 PLG
44 carotid artery disease 9.6 APOA1 APOB PLG
45 degeneration of macula and posterior pole 9.6 C3 PLG
46 intermediate coronary syndrome 9.6 F3 PLG
47 vein disease 9.5 F3 PLG
48 cerebral falx meningioma 9.4 F3 PGRMC1 PLG
49 anterior cranial fossa meningioma 9.4 F3 PGRMC1 PLG
50 body mass index quantitative trait locus 11 9.4 APOA1 APOB C3 SERPINE1

Graphical network of the top 20 diseases related to Dysbaric Osteonecrosis:



Diseases related to Dysbaric Osteonecrosis

Symptoms & Phenotypes for Dysbaric Osteonecrosis

MGI Mouse Phenotypes related to Dysbaric Osteonecrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 PLG SERPINE1 APOA1 APOB C3 COMT
2 homeostasis/metabolism MP:0005376 9.61 SERPINE1 ALX3 APOA1 APOB C3 COMT
3 renal/urinary system MP:0005367 9.02 PLG SERPINE1 C3 COMT ECI1

Drugs & Therapeutics for Dysbaric Osteonecrosis

Search Clinical Trials , NIH Clinical Center for Dysbaric Osteonecrosis

Genetic Tests for Dysbaric Osteonecrosis

Anatomical Context for Dysbaric Osteonecrosis

The Foundational Model of Anatomy Ontology organs/tissues related to Dysbaric Osteonecrosis:

19
Bone

MalaCards organs/tissues related to Dysbaric Osteonecrosis:

41
Bone

Publications for Dysbaric Osteonecrosis

Articles related to Dysbaric Osteonecrosis:

(show all 47)
# Title Authors Year
1
Diving, Dysbaric Osteonecrosis ( 29493935 )
2018
2
Extravascular Hydrophobic Surfaces, Fat Droplets, and the Connection With Decompression Illness: Spinal, Joint Pain, and Dysbaric Osteonecrosis. ( 29636703 )
2018
3
A case of a young diving fisherman with complicated dysbaric osteonecrosis. ( 28154292 )
2017
4
Dysbaric osteonecrosis in professional divers: two case reports. ( 26403020 )
2015
5
Predictive factors of dysbaric osteonecrosis following musculoskeletal decompression sickness in recreational SCUBA divers. ( 26454506 )
2015
6
Dysbaric Osteonecrosis: A Literature Review of Pathophysiology, Clinical Presentation, and Management. ( 24662571 )
2014
7
A study on dysbaric osteonecrosis in caisson workers. ( 24984318 )
2014
8
Dysbaric osteonecrosis in divers: an editorial perspective. ( 25562940 )
2014
9
Dysbaric osteonecrosis among professional divers: a literature review. ( 25562949 )
2014
10
Dysbaric osteonecrosis in recreational divers: a study using magnetic resonance imaging. ( 20929185 )
2010
11
Musculoskeletal decompression sickness and risk of dysbaric osteonecrosis in recreational divers. ( 22752739 )
2009
12
MRI screening of dysbaric osteonecrosis in hyperbaric-chamber inside attendants. ( 18380930 )
2008
13
Dysbaric osteonecrosis screening in Turkish Navy divers. ( 18225777 )
2008
14
Role of MRI in the detection of marrow bubbles after musculoskeletal decompression sickness predictive of subsequent dysbaric osteonecrosis. ( 18996270 )
2008
15
Dysbaric osteonecrosis in experienced dive masters and instructors. ( 18064920 )
2007
16
Risk factors for dysbaric osteonecrosis. ( 16436490 )
2006
17
Dysbaric osteonecrosis by X-ray and CT scan in Chinese divers. ( 16119308 )
2005
18
Detection of dysbaric osteonecrosis in military divers using magnetic resonance imaging. ( 15490180 )
2005
19
Dysbaric osteonecrosis screening in submarine escape instructors. ( 15328783 )
2004
20
Dysbaric osteonecrosis in Turkish sponge divers. ( 11908699 )
2001
21
Dysbaric osteonecrosis: a reassessment and hypothesis. ( 10859644 )
2000
22
Dysbaric osteonecrosis of the shoulder in a sport scuba diver. ( 9865412 )
1998
23
Dysbaric osteonecrosis in divers and caisson workers. An animal model. ( 9372784 )
1997
24
Pathophysiology of dysbaric osteonecrosis: a magnetic resonance imaging study. ( 8840481 )
1996
25
Dysbaric osteonecrosis of the femoral diametaphysis. ( 8502403 )
1993
26
The pathophysiologic role of fat in dysbaric osteonecrosis. ( 8222435 )
1993
27
Delayed occurrence of dysbaric osteonecrosis: 17 cases. ( 1561720 )
1992
28
Dysbaric osteonecrosis in a compressed air tunnelling project in Hong Kong. ( 1571528 )
1992
29
Dysbaric osteonecrosis. ( 1859573 )
1991
30
Distribution of lesions in the head and neck of the humerus and the femur in dysbaric osteonecrosis. ( 2396333 )
1990
31
Does dysbaric osteonecrosis progress in the absence of further hyperbaric exposure? A 10-year radiologic follow-up of 15 patients. ( 2112875 )
1990
32
Use of ultrasonography in the diagnosis of dysbaric osteonecrosis. ( 2288044 )
1990
33
Dysbaric osteonecrosis (caisson disease). ( 3268097 )
1988
34
Bone imaging and skeletal radiology in dysbaric osteonecrosis. ( 3690960 )
1987
35
Dysbaric osteonecrosis (caisson disease of bone): are active oxygen species and the endocrine system responsible, and can control of the production of free radicals and their reaction products confer protection? ( 3333753 )
1987
36
Dysbaric osteonecrosis in differential diagnosis of malignant bone disease. ( 3999085 )
1985
37
Functional imaging in the early diagnosis of dysbaric osteonecrosis. ( 7150897 )
1982
38
Bone scintigraphy as an investigative aid for dysbaric osteonecrosis in divers. ( 7131370 )
1982
39
Animal model of human disease: dysbaric osteonecrosis. ( 7234968 )
1981
40
Prevention of dysbaric osteonecrosis in compressed-air workers. ( 639383 )
1978
41
Dysbaric osteonecrosis. Etiological and pathogenetic concepts. ( 639412 )
1978
42
Incidence of dysbaric osteonecrosis in Hawaii's diving fishermen. ( 675879 )
1978
43
The significance of bone islands, cystic areas and sclerotic areas in dysbaric osteonecrosis. ( 872504 )
1977
44
Bone collagen in dysbaric osteonecrosis. ( 598134 )
1977
45
Serum ferritin and dysbaric osteonecrosis. ( 855015 )
1977
46
Dysbaric osteonecrosis in mice. ( 951827 )
1976
47
Radiology of Dysbaric osteonecrosis. ( 4648523 )
1972

Variations for Dysbaric Osteonecrosis

Expression for Dysbaric Osteonecrosis

Search GEO for disease gene expression data for Dysbaric Osteonecrosis.

Pathways for Dysbaric Osteonecrosis

GO Terms for Dysbaric Osteonecrosis

Cellular components related to Dysbaric Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.88 APOA1 APOB C3 F3 PLG SERPINE1
2 extracellular matrix GO:0031012 9.63 APOA1 F3 SERPINE1
3 blood microparticle GO:0072562 9.61 APOA1 C3 PLG
4 very-low-density lipoprotein particle GO:0034361 9.37 APOA1 APOB
5 endocytic vesicle lumen GO:0071682 9.32 APOA1 APOB
6 extracellular exosome GO:0070062 9.28 APOA1 APOB C3 COMT ECI1 F3
7 low-density lipoprotein particle GO:0034362 9.26 APOA1 APOB
8 chylomicron GO:0042627 9.16 APOA1 APOB
9 intermediate-density lipoprotein particle GO:0034363 8.96 APOA1 APOB

Biological processes related to Dysbaric Osteonecrosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.84 APOA1 APOB C3 ECI1
2 positive regulation of angiogenesis GO:0045766 9.61 C3 F3 SERPINE1
3 platelet degranulation GO:0002576 9.58 APOA1 PLG SERPINE1
4 cholesterol transport GO:0030301 9.52 APOA1 APOB
5 triglyceride catabolic process GO:0019433 9.51 APOA1 APOB
6 cholesterol efflux GO:0033344 9.49 APOA1 APOB
7 lipoprotein metabolic process GO:0042157 9.48 APOA1 APOB
8 fibrinolysis GO:0042730 9.46 PLG SERPINE1
9 positive regulation of lipid storage GO:0010884 9.37 APOB C3
10 chylomicron assembly GO:0034378 9.32 APOA1 APOB
11 negative regulation of fibrinolysis GO:0051918 9.26 PLG SERPINE1
12 chylomicron remodeling GO:0034371 9.16 APOA1 APOB
13 lipoprotein biosynthetic process GO:0042158 8.96 APOA1 APOB
14 cellular protein metabolic process GO:0044267 8.92 APOA1 APOB C3 PLG

Molecular functions related to Dysbaric Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 9.16 APOA1 APOB
2 cholesterol transporter activity GO:0017127 8.96 APOA1 APOB
3 phospholipid binding GO:0005543 8.8 APOA1 APOB F3

Sources for Dysbaric Osteonecrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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