DON
MCID: DYS013
MIFTS: 37

Dysbaric Osteonecrosis (DON)

Categories: Bone diseases

Aliases & Classifications for Dysbaric Osteonecrosis

MalaCards integrated aliases for Dysbaric Osteonecrosis:

Name: Dysbaric Osteonecrosis 12 15 73
Caisson Disease of Bone 12
Don 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080018
UMLS 73 C3494941

Summaries for Dysbaric Osteonecrosis

Disease Ontology : 12 An ischemic bone disease the has material basis in nitrogen embolization located in bone.

MalaCards based summary : Dysbaric Osteonecrosis, also known as caisson disease of bone, is related to osteonecrosis and conversion disorder. An important gene associated with Dysbaric Osteonecrosis is ECI1 (Enoyl-CoA Delta Isomerase 1), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Selenium Micronutrient Network. Affiliated tissues include bone, bone and endothelial, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 Dysbaric osteonecrosis or DON is a form of avascular necrosis where there is death of a portion of the... more...

Related Diseases for Dysbaric Osteonecrosis

Diseases related to Dysbaric Osteonecrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 11.0
2 conversion disorder 10.2 COMT ALX3
3 hyperlipoproteinemia, type v 10.2 APOA1 APOB
4 leukodystrophy, hypomyelinating, 3 10.2 APOA1 APOB
5 hyperlipidemia, familial combined 10.2 APOA1 APOB
6 thrombosis 10.2
7 bone disease 10.2
8 ischemic heart disease 10.2 APOA1 APOB
9 hypolipoproteinemia 10.2 APOA1 APOB
10 fetal macrosomia 10.2 APOA1 APOB
11 hypoalphalipoproteinemia, primary 10.1 APOA1 APOB
12 chylomicron retention disease 10.1 APOA1 APOB
13 vitamin e, familial isolated deficiency of 10.1 APOA1 APOB
14 hypobetalipoproteinemia, familial, 2 10.1 APOA1 APOB
15 ascaridiasis 10.1 STH PLG
16 catastrophic antiphospholipid syndrome 10.1 F3 SERPINE1
17 carotid artery thrombosis 10.1 F3 SERPINE1
18 hypertriglyceridemia, familial 10.1 APOA1 APOB
19 pneumoconiosis 10.1
20 factor xiii deficiency 10.1 F3 SERPINE1
21 tuberculous empyema 10.0 SERPINE1 PLG
22 coronary stenosis 10.0 SERPINE1 APOB APOA1
23 familial hyperlipidemia 10.0 SERPINE1 APOB APOA1
24 conjugate gaze palsy 10.0 PLG F3
25 livedoid vasculitis 10.0 PLG SERPINE1
26 acute cor pulmonale 10.0 PLG SERPINE1
27 intestinal impaction 10.0 PLG F3
28 leech infestation 10.0 PLG F3
29 giant hemangioma 10.0 F3 PLG
30 acute pulmonary heart disease 10.0 PLG SERPINE1
31 femoral neuropathy 10.0 F3 PLG
32 korean hemorrhagic fever 10.0 F3 PLG
33 coronary thrombosis 10.0 F3 SERPINE1
34 vertebral artery occlusion 10.0 F3 PLG
35 vertebrobasilar insufficiency 10.0 C3 F3
36 arteriolosclerosis 10.0 ADIPOQ C3
37 intracranial thrombosis 10.0 F3 PLG
38 endocardium disease 10.0 F3 PLG
39 carotid artery disease 10.0 PLG APOB APOA1
40 intermediate coronary syndrome 10.0 F3 PLG
41 abdominal obesity-metabolic syndrome 1 10.0 ADIPOQ SERPINE1
42 cerebral falx meningioma 9.9 PLG PGRMC1 F3
43 hyperlipoproteinemia, type iii 9.9 APOA1 APOB
44 anterior cranial fossa meningioma 9.9 PLG PGRMC1 F3
45 prediabetes syndrome 9.9 ADIPOQ APOB
46 pulmonary artery disease 9.9 F3 PLG
47 inherited metabolic disorder 9.9 APOB APOA1 ADIPOQ
48 macular degeneration, age-related, 1 9.9 APOB C3 PLG
49 blue toe syndrome 9.9 SERPINE1 PLG F3
50 hepatic vascular disease 9.9 SERPINE1 PLG F3

Graphical network of the top 20 diseases related to Dysbaric Osteonecrosis:



Diseases related to Dysbaric Osteonecrosis

Symptoms & Phenotypes for Dysbaric Osteonecrosis

MGI Mouse Phenotypes related to Dysbaric Osteonecrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 ADIPOQ ALX3 APOA1 APOB C3 COMT
2 cardiovascular system MP:0005385 10.01 ADIPOQ APOA1 APOB C3 COMT F3
3 endocrine/exocrine gland MP:0005379 9.91 ADIPOQ ALX3 APOA1 C3 COMT PGRMC1
4 nervous system MP:0003631 9.76 ADIPOQ ALX3 APOB C3 COMT F3
5 liver/biliary system MP:0005370 9.73 ADIPOQ APOA1 APOB C3 PLG SERPINE1
6 renal/urinary system MP:0005367 9.43 ADIPOQ C3 COMT ECI1 PLG SERPINE1
7 respiratory system MP:0005388 9.1 ADIPOQ ALX3 COMT F3 PLG SERPINE1

Drugs & Therapeutics for Dysbaric Osteonecrosis

Search Clinical Trials , NIH Clinical Center for Dysbaric Osteonecrosis

Genetic Tests for Dysbaric Osteonecrosis

Anatomical Context for Dysbaric Osteonecrosis

The Foundational Model of Anatomy Ontology organs/tissues related to Dysbaric Osteonecrosis:

19
Bone

MalaCards organs/tissues related to Dysbaric Osteonecrosis:

41
Bone, Endothelial, Heart, Pancreas

Publications for Dysbaric Osteonecrosis

Articles related to Dysbaric Osteonecrosis:

(show all 49)
# Title Authors Year
1
Diving, Dysbaric Osteonecrosis ( 29493935 )
2018
2
Extravascular Hydrophobic Surfaces, Fat Droplets, and the Connection With Decompression Illness: Spinal, Joint Pain, and Dysbaric Osteonecrosis. ( 29636703 )
2018
3
A case of a young diving fisherman with complicated dysbaric osteonecrosis. ( 28154292 )
2017
4
Predictive factors of dysbaric osteonecrosis following musculoskeletal decompression sickness in recreational SCUBA divers. ( 26454506 )
2016
5
Dysbaric osteonecrosis in professional divers: two case reports. ( 26403020 )
2015
6
Dysbaric Osteonecrosis: A Literature Review of Pathophysiology, Clinical Presentation, and Management. ( 24662571 )
2014
7
A study on dysbaric osteonecrosis in caisson workers. ( 24984318 )
2014
8
Dysbaric osteonecrosis in divers: an editorial perspective. ( 25562940 )
2014
9
Dysbaric osteonecrosis among professional divers: a literature review. ( 25562949 )
2014
10
Dysbaric osteonecrosis in recreational divers: a study using magnetic resonance imaging. ( 20929185 )
2010
11
Musculoskeletal decompression sickness and risk of dysbaric osteonecrosis in recreational divers. ( 22752739 )
2009
12
MRI screening of dysbaric osteonecrosis in hyperbaric-chamber inside attendants. ( 18380930 )
2008
13
Dysbaric osteonecrosis screening in Turkish Navy divers. ( 18225777 )
2008
14
Role of MRI in the detection of marrow bubbles after musculoskeletal decompression sickness predictive of subsequent dysbaric osteonecrosis. ( 18996270 )
2008
15
Dysbaric osteonecrosis in experienced dive masters and instructors. ( 18064920 )
2007
16
Risk factors for dysbaric osteonecrosis. ( 16436490 )
2006
17
Dysbaric osteonecrosis by X-ray and CT scan in Chinese divers. ( 16119308 )
2005
18
Detection of dysbaric osteonecrosis in military divers using magnetic resonance imaging. ( 15490180 )
2005
19
Dysbaric osteonecrosis screening in submarine escape instructors. ( 15328783 )
2004
20
Dysbaric osteonecrosis in Turkish sponge divers. ( 11908699 )
2001
21
Dysbaric osteonecrosis: a reassessment and hypothesis. ( 10859644 )
2000
22
Dysbaric osteonecrosis of the shoulder in a sport scuba diver. ( 9865412 )
1998
23
Dysbaric osteonecrosis in divers and caisson workers. An animal model. ( 9372784 )
1997
24
Pathophysiology of dysbaric osteonecrosis: a magnetic resonance imaging study. ( 8840481 )
1996
25
Dysbaric osteonecrosis of the femoral diametaphysis. ( 8502403 )
1993
26
The pathophysiologic role of fat in dysbaric osteonecrosis. ( 8222435 )
1993
27
Delayed occurrence of dysbaric osteonecrosis: 17 cases. ( 1561720 )
1992
28
Dysbaric osteonecrosis in a compressed air tunnelling project in Hong Kong. ( 1571528 )
1992
29
Dysbaric osteonecrosis. ( 1859573 )
1991
30
Distribution of lesions in the head and neck of the humerus and the femur in dysbaric osteonecrosis. ( 2396333 )
1990
31
Does dysbaric osteonecrosis progress in the absence of further hyperbaric exposure? A 10-year radiologic follow-up of 15 patients. ( 2112875 )
1990
32
Use of ultrasonography in the diagnosis of dysbaric osteonecrosis. ( 2288044 )
1990
33
Dysbaric osteonecrosis (caisson disease). ( 3268097 )
1988
34
Dysbaric osteonecrosis and its radiographic classification in China. ( 3201635 )
1988
35
Bone imaging and skeletal radiology in dysbaric osteonecrosis. ( 3690960 )
1987
36
Dysbaric osteonecrosis (caisson disease of bone): are active oxygen species and the endocrine system responsible, and can control of the production of free radicals and their reaction products confer protection? ( 3333753 )
1987
37
Dysbaric osteonecrosis in differential diagnosis of malignant bone disease. ( 3999085 )
1985
38
Functional imaging in the early diagnosis of dysbaric osteonecrosis. ( 7150897 )
1982
39
Bone scintigraphy as an investigative aid for dysbaric osteonecrosis in divers. ( 7131370 )
1982
40
Animal model of human disease: dysbaric osteonecrosis. ( 7234968 )
1981
41
Dysbaric osteonecrosis: a consequence of intravascular bubble formation, endothelial damage, and platelet thrombosis. ( 7288270 )
1981
42
Prevention of dysbaric osteonecrosis in compressed-air workers. ( 639383 )
1978
43
Dysbaric osteonecrosis. Etiological and pathogenetic concepts. ( 639412 )
1978
44
Incidence of dysbaric osteonecrosis in Hawaii's diving fishermen. ( 675879 )
1978
45
The significance of bone islands, cystic areas and sclerotic areas in dysbaric osteonecrosis. ( 872504 )
1977
46
Bone collagen in dysbaric osteonecrosis. ( 598134 )
1977
47
Serum ferritin and dysbaric osteonecrosis. ( 855015 )
1977
48
Dysbaric osteonecrosis in mice. ( 951827 )
1976
49
Radiology of Dysbaric osteonecrosis. ( 4648523 )
1972

Variations for Dysbaric Osteonecrosis

Expression for Dysbaric Osteonecrosis

Search GEO for disease gene expression data for Dysbaric Osteonecrosis.

Pathways for Dysbaric Osteonecrosis

GO Terms for Dysbaric Osteonecrosis

Cellular components related to Dysbaric Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ADIPOQ APOA1 APOB C3 F3 PLG
2 blood microparticle GO:0072562 9.61 APOA1 C3 PLG
3 very-low-density lipoprotein particle GO:0034361 9.4 APOA1 APOB
4 endocytic vesicle lumen GO:0071682 9.37 APOA1 APOB
5 low-density lipoprotein particle GO:0034362 9.32 APOA1 APOB
6 chylomicron GO:0042627 9.26 APOA1 APOB
7 collagen-containing extracellular matrix GO:0062023 9.02 ADIPOQ APOA1 F3 PLG SERPINE1
8 intermediate-density lipoprotein particle GO:0034363 8.96 APOA1 APOB
9 extracellular region GO:0005576 10 ADIPOQ APOA1 APOB C3 F3 PLG

Biological processes related to Dysbaric Osteonecrosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.88 APOA1 APOB C3 ECI1
2 positive regulation of angiogenesis GO:0045766 9.63 C3 F3 SERPINE1
3 platelet degranulation GO:0002576 9.61 APOA1 PLG SERPINE1
4 positive regulation of interleukin-8 production GO:0032757 9.57 ADIPOQ SERPINE1
5 cholesterol transport GO:0030301 9.56 APOA1 APOB
6 triglyceride catabolic process GO:0019433 9.55 APOA1 APOB
7 cholesterol efflux GO:0033344 9.54 APOA1 APOB
8 lipoprotein metabolic process GO:0042157 9.52 APOA1 APOB
9 low-density lipoprotein particle clearance GO:0034383 9.51 ADIPOQ APOB
10 fibrinolysis GO:0042730 9.49 PLG SERPINE1
11 negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 9.48 ADIPOQ APOA1
12 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.4 ADIPOQ APOA1
13 positive regulation of lipid storage GO:0010884 9.37 APOB C3
14 chylomicron assembly GO:0034378 9.32 APOA1 APOB
15 negative regulation of fibrinolysis GO:0051918 9.26 PLG SERPINE1
16 chylomicron remodeling GO:0034371 9.16 APOA1 APOB
17 lipoprotein biosynthetic process GO:0042158 8.96 APOA1 APOB
18 cellular protein metabolic process GO:0044267 8.92 APOA1 APOB C3 PLG

Molecular functions related to Dysbaric Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 9.26 APOA1 APOB
2 signaling receptor binding GO:0005102 9.26 ADIPOQ C3 PLG SERPINE1
3 cholesterol transporter activity GO:0017127 9.16 APOA1 APOB
4 phospholipid binding GO:0005543 8.8 APOA1 APOB F3

Sources for Dysbaric Osteonecrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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