DON
MCID: DYS013
MIFTS: 32

Dysbaric Osteonecrosis (DON)

Categories: Bone diseases

Aliases & Classifications for Dysbaric Osteonecrosis

MalaCards integrated aliases for Dysbaric Osteonecrosis:

Name: Dysbaric Osteonecrosis 12 15 72
Caisson Disease of Bone 12
Don 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080018
UMLS 72 C3494941

Summaries for Dysbaric Osteonecrosis

Disease Ontology : 12 An ischemic bone disease the has material basis in nitrogen embolization located in bone.

MalaCards based summary : Dysbaric Osteonecrosis, also known as caisson disease of bone, is related to osteonecrosis and conversion disorder. An important gene associated with Dysbaric Osteonecrosis is ECI1 (Enoyl-CoA Delta Isomerase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and IL-1 Family Signaling Pathways. Affiliated tissues include bone, bone and endothelial, and related phenotypes are cardiovascular system and embryo

Wikipedia : 75 Dysbaric osteonecrosis or DON is a form of avascular necrosis where there is death of a portion of the... more...

Related Diseases for Dysbaric Osteonecrosis

Diseases related to Dysbaric Osteonecrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 11.1
2 conversion disorder 10.5 COMT ALX3
3 ascaridiasis 10.5 STH PLG
4 leukodystrophy, hypomyelinating, 3 10.5 APOB APOA1
5 hyperlipoproteinemia, type v 10.5 APOB APOA1
6 hypolipoproteinemia 10.4 APOB APOA1
7 fetal macrosomia 10.4 APOB APOA1
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
9 hypobetalipoproteinemia, familial, 2 10.3 APOB APOA1
10 vitamin e, familial isolated deficiency of 10.3 APOB APOA1
11 chylomicron retention disease 10.3 APOB APOA1
12 tuberculous empyema 10.3 SERPINE1 PLG
13 acute cor pulmonale 10.2 SERPINE1 PLG
14 livedoid vasculitis 10.2 SERPINE1 PLG
15 hypertriglyceridemia, familial 10.2 APOB APOA1
16 carotid artery disease 10.2 PLG APOB APOA1
17 bone disease 10.2
18 disseminated intravascular coagulation 10.2
19 compartment syndrome 10.2
20 avascular necrosis 10.2
21 conjugate gaze palsy 10.2 PLG F3
22 cerebral falx meningioma 10.2 PLG F3
23 acute pulmonary heart disease 10.2 SERPINE1 PLG
24 intestinal impaction 10.2 PLG F3
25 leech infestation 10.2 PLG F3
26 giant hemangioma 10.2 PLG F3
27 femoral neuropathy 10.2 PLG F3
28 anterior cranial fossa meningioma 10.1 PLG F3
29 korean hemorrhagic fever 10.1 PLG F3
30 vertebral artery occlusion 10.1 PLG F3
31 coronary stenosis 10.1 SERPINE1 APOB APOA1
32 intracranial thrombosis 10.1 PLG F3
33 familial hyperlipidemia 10.1 SERPINE1 APOB APOA1
34 lipid metabolism disorder 10.1 SERPINE1 APOB APOA1
35 pneumoconiosis 10.1
36 anthracosis 10.1
37 osteoarthritis 10.1
38 acquired metabolic disease 10.1 SERPINE1 APOB APOA1
39 atherosclerosis susceptibility 10.1 SERPINE1 APOB APOA1
40 coronary heart disease 1 10.0 SERPINE1 APOB APOA1
41 endocardium disease 10.0 PLG F3
42 cerebrovascular disease 10.0 SERPINE1 APOB APOA1
43 intermediate coronary syndrome 10.0 PLG F3
44 catastrophic antiphospholipid syndrome 10.0 SERPINE1 F3
45 macular degeneration, age-related, 1 10.0 PLG C3 APOB
46 carotid artery thrombosis 10.0 SERPINE1 F3
47 factor xiii deficiency 10.0 SERPINE1 F3
48 pulmonary artery disease 9.9 PLG F3
49 hyperlipoproteinemia, type iii 9.9 APOB APOA1
50 coronary thrombosis 9.9 SERPINE1 F3

Graphical network of the top 20 diseases related to Dysbaric Osteonecrosis:



Diseases related to Dysbaric Osteonecrosis

Symptoms & Phenotypes for Dysbaric Osteonecrosis

MGI Mouse Phenotypes related to Dysbaric Osteonecrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 APOA1 APOB C3 COMT F3 PLG
2 embryo MP:0005380 9.43 ALX3 APOB C3 COMT F3 SHC1
3 homeostasis/metabolism MP:0005376 9.32 ALX3 APOA1 APOB C3 COMT ECI1

Drugs & Therapeutics for Dysbaric Osteonecrosis

Search Clinical Trials , NIH Clinical Center for Dysbaric Osteonecrosis

Genetic Tests for Dysbaric Osteonecrosis

Anatomical Context for Dysbaric Osteonecrosis

The Foundational Model of Anatomy Ontology organs/tissues related to Dysbaric Osteonecrosis:

19
Bone

MalaCards organs/tissues related to Dysbaric Osteonecrosis:

41
Bone, Endothelial

Publications for Dysbaric Osteonecrosis

Articles related to Dysbaric Osteonecrosis:

(show top 50) (show all 85)
# Title Authors PMID Year
1
Dysbaric osteonecrosis associated with decompression sickness in a fishing diver 38
31051069 2019
2
[The value of MRI in early diagnosis of dysbaric osteonecrosis]. 38
30248746 2018
3
Extravascular Hydrophobic Surfaces, Fat Droplets, and the Connection With Decompression Illness: Spinal, Joint Pain, and Dysbaric Osteonecrosis. 38
29636703 2018
4
Health effects of hyperbaric exposure on chamber attendants: a literature review. 38
29611615 2018
5
A case of a young diving fisherman with complicated dysbaric osteonecrosis. 38
28154292 2017
6
Predictive factors of dysbaric osteonecrosis following musculoskeletal decompression sickness in recreational SCUBA divers. 38
26454506 2016
7
Dysbaric osteonecrosis in professional divers: two case reports. 38
26403020 2015
8
Dysbaric osteonecrosis: a literature review of pathophysiology, clinical presentation, and management. 38
24662571 2015
9
Dysbaric osteonecrosis among professional divers: a literature review. 38
25562949 2014
10
Dysbaric osteonecrosis in divers: an editorial perspective. 38
25562940 2014
11
A study on dysbaric osteonecrosis in caisson workers. 38
24984318 2014
12
The use of Diagnostic Imaging for Identifying Abnormal Gas Accumulations in Cetaceans and Pinnipeds. 38
22685439 2012
13
[The image diagnosis of dysbaric osteonecrosis]. 38
22468304 2011
14
Paranasal sinus mucosal hypertrophy in experienced divers. 38
21961405 2011
15
Osteological pathology in a Humpback (Megaptera novaeangliae) and Fin (Balaenoptera physalus) whale skeleton. 38
29539319 2011
16
Dysbaric osteonecrosis in recreational divers: a study using magnetic resonance imaging. 38
20929185 2010
17
Musculoskeletal decompression sickness and risk of dysbaric osteonecrosis in recreational divers. 38
22752739 2009
18
Sponge divers of the Aegean and medical consequences of risky compressed-air dive profiles. 38
19378916 2009
19
Role of MRI in the detection of marrow bubbles after musculoskeletal decompression sickness predictive of subsequent dysbaric osteonecrosis. 38
18996270 2008
20
MRI screening of dysbaric osteonecrosis in hyperbaric-chamber inside attendants. 38
18380930 2008
21
Dysbaric osteonecrosis screening in Turkish Navy divers. 38
18225777 2008
22
Oxygen pre-breathing decreases dysbaric diseases in UW sheep undergoing hyperbaric exposure. 38
18351128 2008
23
Dysbaric osteonecrosis in experienced dive masters and instructors. 38
18064920 2007
24
Risk factors for dysbaric osteonecrosis. 38
16436490 2006
25
[Early detection of asymptomatic dysbaric osteonecrosis of the shoulder after type 1 decompression sickness: a case report]. 38
15936481 2005
26
Dysbaric osteonecrosis by X-ray and CT scan in Chinese divers. 38
16119308 2005
27
Detection of dysbaric osteonecrosis in military divers using magnetic resonance imaging. 38
15490180 2005
28
The role of radiology in dive-related disorders. 38
15724856 2005
29
Cumulative sperm whale bone damage and the bends. 38
15618509 2004
30
Aseptic bone necrosis in an amateur scuba diver. 38
15388563 2004
31
Dysbaric osteonecrosis screening in submarine escape instructors. 38
15328783 2004
32
Health and safety issues relating to Maine's fishing industry. 38
19785219 2004
33
Hyperbaric oxygen therapy in orthopedic conditions. 38
15233171 2004
34
Dysbaric osteonecrosis in Turkish sponge divers. 38
11908699 2001
35
Dysbaric osteonecrosis: a reassessment and hypothesis. 38
10859644 2000
36
Dysbaric osteonecrosis of the shoulder in a sport scuba diver. 38
9865412 1998
37
Diving pattern and work schedule of construction well divers in Taiwan. 38
9670435 1998
38
Dysbaric osteonecrosis in divers and caisson workers. An animal model. 38
9372784 1997
39
Compressed air tunneling and caisson work decompression procedures: development, problems, and solutions. 38
9444066 1997
40
Pathophysiology of dysbaric osteonecrosis: a magnetic resonance imaging study. 38
8840481 1996
41
Prevalence of decompression sickness among U-2 pilots. 38
8775396 1996
42
[Dysbaric osteonecrosis in professional divers: MRT as a screening method?]. 38
7948980 1994
43
The pathophysiologic role of fat in dysbaric osteonecrosis. 38
8222435 1993
44
Dysbaric osteonecrosis of the femoral diametaphysis. 38
8502403 1993
45
Delayed occurrence of dysbaric osteonecrosis: 17 cases. 38
1561720 1992
46
Dysbaric osteonecrosis in a compressed air tunnelling project in Hong Kong. 38
1571528 1992
47
Dysbaric osteonecrosis. 38
1859573 1991
48
Use of ultrasonography in the diagnosis of dysbaric osteonecrosis. 38
2288044 1990
49
Distribution of lesions in the head and neck of the humerus and the femur in dysbaric osteonecrosis. 38
2396333 1990
50
Does dysbaric osteonecrosis progress in the absence of further hyperbaric exposure? A 10-year radiologic follow-up of 15 patients. 38
2112875 1990

Variations for Dysbaric Osteonecrosis

Expression for Dysbaric Osteonecrosis

Search GEO for disease gene expression data for Dysbaric Osteonecrosis.

Pathways for Dysbaric Osteonecrosis

GO Terms for Dysbaric Osteonecrosis

Cellular components related to Dysbaric Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 SERPINE1 PLG F3 C3 APOB APOA1
2 blood microparticle GO:0072562 9.58 PLG C3 APOA1
3 very-low-density lipoprotein particle GO:0034361 9.37 APOB APOA1
4 endocytic vesicle lumen GO:0071682 9.32 APOB APOA1
5 low-density lipoprotein particle GO:0034362 9.26 APOB APOA1
6 collagen-containing extracellular matrix GO:0062023 9.26 SERPINE1 PLG F3 APOA1
7 chylomicron GO:0042627 9.16 APOB APOA1
8 intermediate-density lipoprotein particle GO:0034363 8.62 APOB APOA1

Biological processes related to Dysbaric Osteonecrosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 9.84 ECI1 C3 APOB APOA1
2 positive regulation of angiogenesis GO:0045766 9.61 SERPINE1 F3 C3
3 platelet degranulation GO:0002576 9.58 SERPINE1 PLG APOA1
4 triglyceride catabolic process GO:0019433 9.52 APOB APOA1
5 cholesterol transport GO:0030301 9.51 APOB APOA1
6 lipoprotein metabolic process GO:0042157 9.49 APOB APOA1
7 cholesterol efflux GO:0033344 9.48 APOB APOA1
8 fibrinolysis GO:0042730 9.46 SERPINE1 PLG
9 positive regulation of lipid storage GO:0010884 9.37 C3 APOB
10 negative regulation of fibrinolysis GO:0051918 9.32 SERPINE1 PLG
11 chylomicron assembly GO:0034378 9.26 APOB APOA1
12 chylomicron remodeling GO:0034371 9.16 APOB APOA1
13 lipoprotein biosynthetic process GO:0042158 8.96 APOB APOA1
14 cellular protein metabolic process GO:0044267 8.92 PLG C3 APOB APOA1

Molecular functions related to Dysbaric Osteonecrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 9.16 APOB APOA1
2 cholesterol transporter activity GO:0017127 8.96 APOB APOA1
3 phospholipid binding GO:0005543 8.92 SHC1 F3 APOB APOA1

Sources for Dysbaric Osteonecrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....