Aliases & Classifications for Dyscalculia

MalaCards integrated aliases for Dyscalculia:

Name: Dyscalculia 12 73 6 44 15 70
Developmental Arithmetic Disorder 70
Disorder of Arithmetical Skills 12
Mathematics Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12568
MeSH 44 D060705
ICD10 32 F81.2
UMLS 70 C0869474 C1411876

Summaries for Dyscalculia

Disease Ontology : 12 A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page.

MalaCards based summary : Dyscalculia, also known as developmental arithmetic disorder, is related to inclusion body myopathy with paget disease of bone and frontotemporal dementia and gerstmann syndrome, and has symptoms including other symbolic dysfunction An important gene associated with Dyscalculia is CFAP47 (Cilia And Flagella Associated Protein 47), and among its related pathways/superpathways is Miscellaneous transport and binding events. Affiliated tissues include brain, parietal lobe and eye, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 73 Dyscalculia (/ˌdɪskælˈkjuːliə/) is a disability resulting in difficulty learning or comprehending... more...

Related Diseases for Dyscalculia

Diseases related to Dyscalculia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 inclusion body myopathy with paget disease of bone and frontotemporal dementia 31.4 VCP TARDBP CHMP2B
2 gerstmann syndrome 31.0 MAPT GRN APOE
3 frontotemporal dementia and/or amyotrophic lateral sclerosis 7 30.6 VCP TARDBP MAPT GRN CHMP2B
4 dyslexia 30.4 NRSN1 KIAA0319 DNAAF4 DCDC2 CFAP47
5 learning disability 30.1 PRODH MAPT KIAA0319 DNAAF4 DCDC2 CFAP47
6 apraxia 29.6 MAPT GRN APOE
7 fragile x syndrome 29.5 TUBGCP5 TARDBP PRODH NIPA2 NIPA1 CYFIP1
8 reading disorder 29.3 NRSN1 KIAA0319 DNAAF4 DCDC2 CFAP47
9 dysgraphia 28.9 TARDBP MAPT KIAA0319 GRN DNAAF4 DCDC2
10 aphasia 28.6 VCP TARDBP MAPT GRN CHMP2B APOE
11 nominal aphasia 28.3 VCP TARDBP MAPT GRN CHMP2B APOE
12 attention deficit-hyperactivity disorder 10.4
13 specific learning disability 10.4
14 atrial septal defect 9 10.3 PRODH CFAP47
15 amyotrophic lateral sclerosis type 14 10.2 VCP CHMP2B
16 x-linked monogenic disease 10.1 PRODH CYFIP1 CFAP47
17 dyslexia 2 10.1 KIAA0319 DCDC2
18 amyotrophic lateral sclerosis 16, juvenile 10.1 VCP CHMP2B
19 amusia 10.1 GRN DCDC2
20 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 10.1 MAPT GRN
21 succinic semialdehyde dehydrogenase deficiency 10.1 PRODH NRSN1 KIAA0319
22 childhood absence epilepsy 10.0 TUBGCP5 NIPA2 NIPA1 CYFIP1
23 echolalia 10.0 PRODH MAPT GRN
24 amyotrophic lateral sclerosis 11 10.0 TARDBP CHMP2B
25 anxiety 10.0
26 allergic disease 10.0
27 gonadal dysgenesis 10.0
28 turner syndrome 10.0
29 pica disease 9.9 TARDBP MAPT
30 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 9.9 TARDBP CHMP2B
31 akinetic mutism 9.9 TARDBP MAPT
32 progressive muscular atrophy 9.9 VCP TARDBP CHMP2B
33 amyotrophic lateral sclerosis type 6 9.9 VCP TARDBP CHMP2B
34 postencephalitic parkinson disease 9.9 TARDBP MAPT
35 prader-willi syndrome 9.9 TUBGCP5 PRODH NIPA2 NIPA1 CYFIP1
36 epilepsy, idiopathic generalized 2 9.9 TARDBP MAPT
37 subjective cognitive decline 9.8 MAPT APOE
38 specific language impairment 9.8 KIAA0319 DNAAF4 DCDC2 CFAP47
39 hand skill, relative 9.8
40 phenylketonuria 9.8
41 synesthesia 9.8
42 agenesis of corpus callosum, cardiac, ocular, and genital syndrome 9.8
43 finger agnosia 9.8
44 epilepsy 9.8
45 central nervous system origin vertigo 9.8
46 benign epilepsy with centrotemporal spikes 9.8
47 agnosia 9.8
48 head injury 9.8
49 seizure disorder 9.8
50 specific language disorder 9.8

Graphical network of the top 20 diseases related to Dyscalculia:



Diseases related to Dyscalculia

Symptoms & Phenotypes for Dyscalculia

UMLS symptoms related to Dyscalculia:


other symbolic dysfunction

MGI Mouse Phenotypes related to Dyscalculia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 APOE CYFIP1 DCDC2 DNAAF4 GRN KIAA0319
2 nervous system MP:0003631 9.36 APOE CHMP2B CYFIP1 DCDC2 DNAAF4 GRN

Drugs & Therapeutics for Dyscalculia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Automatization of Counting Procedures in Children With Dyscalculia Completed NCT03354481
2 Improving Math Deficits in Children With Dyscalculia by tRNS: a Randomized, Double-blind Study Recruiting NCT04242680
3 Improving the Academic Performance of First-Grade Students With Reading and Math Difficulty Enrolling by invitation NCT03991234
4 Facilitating Numerical Processing With Transcranial DC Stimulation in Developmental Dyscalculia Withdrawn NCT01195961

Search NIH Clinical Center for Dyscalculia

Cochrane evidence based reviews: dyscalculia

Genetic Tests for Dyscalculia

Anatomical Context for Dyscalculia

MalaCards organs/tissues related to Dyscalculia:

40
Brain, Parietal Lobe, Eye, Bone, Cerebellum, Skin, Temporal Lobe

Publications for Dyscalculia

Articles related to Dyscalculia:

(show top 50) (show all 448)
# Title Authors PMID Year
1
The co-occurrence of Attention-Deficit/Hyperactivity Disorder and mathematical difficulties: An investigation of the role of basic numerical skills. 61
33607486 2021
2
No evidence for a core deficit in developmental dyscalculia or mathematical learning disabilities. 61
33684972 2021
3
Language difficulties are a shared risk factor for both reading disorder and mathematics disorder. 61
33126134 2021
4
Underpinning implications of instructional strategies on assistive technology for learning disability: a meta-synthesis review. 61
33449814 2021
5
Clinical and radiological features of posterior cortical atrophy (PCA) in a GRN mutation carrier: a case report. 61
33030763 2021
6
Arithmetic processing in children with dyscalculia: an event-related potential study. 61
33569247 2021
7
Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). 61
32692463 2021
8
Cognitive correlates of dyslexia, dyscalculia and comorbid dyslexia/dyscalculia: Effects of numerical magnitude processing and phonological processing. 61
33152663 2020
9
The ratio processing system and its role in fraction understanding: Evidence from a match-to-sample task in children and adults with and without dyscalculia. 61
32567513 2020
10
An epidemiological study of prevalence and comorbidity of non-clinical Dyslexia, Dysgraphia and Dyscalculia symptoms in Public and Private Schools of Pakistan. 61
33235593 2020
11
Do children have Bayesian intuitions? 61
33119349 2020
12
Excessive visual crowding effects in developmental dyscalculia. 61
32756882 2020
13
Mathematical Profile Test: A Preliminary Evaluation of an Online Assessment for Mathematics Skills of Children in Grades 1-6. 61
32759837 2020
14
Short-term numerosity training promotes symbolic arithmetic in children with developmental dyscalculia: The mediating role of visual form perception. 61
31599035 2020
15
Efficacy of neuropsychological rehabilitation on numerical and calculation abilities: A developmental case study. 61
30609908 2020
16
Specific learning disorders in sex chromosome aneuploidies: Neural circuits of literacy and mathematics. 61
32463563 2020
17
Different neural activations for an approaching friend versus stranger: Linking personal space to numerical cognition. 61
32342617 2020
18
Summer-born struggle: The effect of school starting age on health, education, and work. 61
32052533 2020
19
Dyscalculia and Typical Math Achievement Are Associated With Individual Differences in Number-Specific Executive Function. 61
30597527 2020
20
Substantiating synesthesia: a novel aid in a case of grapheme-colour synesthesia and concomitant dyscalculia. 61
31774036 2020
21
Impaired large numerosity estimation and intact subitizing in developmental dyscalculia. 61
33382740 2020
22
Report of a Case of Creutzfeldt-Jakob Disease With an Unusual Clinical Presentation. 61
32327983 2020
23
Persistent Differences in Brain Structure in Developmental Dyscalculia: A Longitudinal Morphometry Study. 61
32765241 2020
24
Learning disabilities: Developmental dyscalculia. 61
32977896 2020
25
IDH1-mutant primary intraventricular gliosarcoma: Case report and systematic review of a rare location and molecular profile. 61
33408906 2020
26
Efficacy of a Computer-Based Learning Program in Children With Developmental Dyscalculia. What Influences Individual Responsiveness? 61
32760306 2020
27
From Schools to Scans: A Neuroeducational Approach to Comorbid Math and Reading Disabilities. 61
33194932 2020
28
Modal-independent Pattern Recognition Deficit in Developmental Dyscalculia Adults: Evidence from Tactile and Visual Enumeration. 61
31682944 2019
29
Are specific learning disorders truly specific, and are they disorders? 61
31685130 2019
30
Teachers, not parents, are able to predict time processing skills in preschoolers. 61
31264234 2019
31
Near optimal encoding of numerosity in typical and dyscalculic development. 61
31520845 2019
32
Specific Learning Disabilities: The Family Physician's Role. 61
31730315 2019
33
The Effectiveness of Web-Based Interventions Delivered to Children and Young People With Neurodevelopmental Disorders: Systematic Review and Meta-Analysis. 61
31682573 2019
34
Safety concerns with human papilloma virus immunization in Japan: Analysis and evaluation of Nagoya City's surveillance data for adverse events. 61
30693675 2019
35
Mathematics Anxiety and Cognitive Performance in Adolescent Students. 61
31488776 2019
36
Academic accommodation strategies for pharmacy students with learning disabilities: What else can be done? 61
31227188 2019
37
Electrophysiological markers of poor versus superior math abilities in healthy individuals. 61
30706598 2019
38
Numerical processing profiles in children with varying degrees of arithmetical achievement. 61
31220772 2019
39
Individual differences in basic numerical skills: The role of executive functions and motor skills. 61
30831383 2019
40
Spontaneous representation of numerosity in typical and dyscalculic development. 61
30683323 2019
41
Volumetric and surface characteristics of gray matter in adult dyslexia and dyscalculia. 61
30738813 2019
42
Multi-method brain imaging reveals impaired representations of number as well as altered connectivity in adults with dyscalculia. 61
29885484 2019
43
A Case of Overlap Posterior Cortical Atrophy and Logopenic Variant Primary Progressive Aphasia. 61
30817493 2019
44
Understanding comorbidity of learning disorders: task-dependent estimates of prevalence. 61
30144072 2019
45
The Diagnosis and Treatment of Dyscalculia. 61
30905334 2019
46
Correction to: Effectiveness of working memory training among children with dyscalculia: evidence for transfer effects on mathematical achievement-a pilot study. 61
30734875 2019
47
Enumeration and Alertness in Developmental Dyscalculia. 61
31517227 2019
48
Persistent Effects of Musical Training on Mathematical Skills of Children With Developmental Dyscalculia. 61
31998179 2019
49
Epilepsy phenotype in patients with Xp22.31 microduplication. 61
30603611 2019
50
Neurostructural correlate of math anxiety in the brain of children. 61
30531959 2018

Variations for Dyscalculia

Expression for Dyscalculia

Search GEO for disease gene expression data for Dyscalculia.

Pathways for Dyscalculia

Pathways related to Dyscalculia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 NIPA2 NIPA1

GO Terms for Dyscalculia

Cellular components related to Dyscalculia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.46 NRSN1 MAPT CYFIP1 APOE
2 endosome GO:0005768 9.35 NIPA2 NIPA1 KIAA0319 GRN CHMP2B
3 early endosome GO:0005769 8.92 NIPA2 NIPA1 KIAA0319 APOE

Biological processes related to Dyscalculia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection development GO:0031175 9.54 MAPT CYFIP1 APOE
2 neuron migration GO:0001764 9.43 KIAA0319 DNAAF4 DCDC2
3 regulation of synapse organization GO:0050807 9.4 VCP APOE
4 regulation of proteasomal protein catabolic process GO:0061136 9.32 DNAAF4 APOE
5 magnesium ion transmembrane transport GO:1903830 9.16 NIPA2 NIPA1
6 nervous system development GO:0007399 9.02 NRSN1 KIAA0319 DNAAF4 DCDC2 CYFIP1
7 magnesium ion transport GO:0015693 8.96 NIPA2 NIPA1

Molecular functions related to Dyscalculia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion transmembrane transporter activity GO:0015095 8.96 NIPA2 NIPA1
2 lipoprotein particle binding GO:0071813 8.62 MAPT APOE

Sources for Dyscalculia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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