MCID: DYS101
MIFTS: 40

Dysgerminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Dysgerminoma

MalaCards integrated aliases for Dysgerminoma:

Name: Dysgerminoma 12 76 29 55 6 44 15

Classifications:



External Ids:

Disease Ontology 12 DOID:4441
MeSH 44 D004407
NCIt 50 C2996
SNOMED-CT 68 60718004
UMLS 73 C0013377

Summaries for Dysgerminoma

Disease Ontology : 12 A germ cell cancer that derives from cells that give rise to egg cells.

MalaCards based summary : Dysgerminoma is related to pediatric ovarian dysgerminoma and dysgerminoma of ovary. An important gene associated with Dysgerminoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Darbepoetin alfa and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include ovary, lung and breast, and related phenotype is neoplasm.

Wikipedia : 76 A dysgerminoma is a type of germ cell tumor; it usually is malignant and usually occurs in the... more...

Related Diseases for Dysgerminoma

Diseases related to Dysgerminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)
# Related Disease Score Top Affiliating Genes
1 pediatric ovarian dysgerminoma 33.9 ALPP ENO2
2 dysgerminoma of ovary 32.7 AFP ALPP BRCA1 ENO2 KIT PTHLH
3 gonadoblastoma 31.6 ALPP KIT SRY TSPY1 WT1
4 gonadal dysgenesis 30.4 SRY TSPY1 WT1
5 mixed germ cell tumor 30.1 AFP KIT
6 teratoma 30.1 AFP ENO2 KIT KRT7
7 papillary carcinoma 30.0 KRT20 KRT7 MUC1
8 malignant teratoma 29.9 AFP ENO2
9 seminoma 29.9 AFP ALPP ENO2 KIT TSPY1
10 cystadenoma 29.8 KRT20 KRT7 MUC1
11 pineal dysgerminoma 12.0
12 malignant dysgerminomatous germ cell tumor of the ovary 11.4
13 diencephalic syndrome 11.1
14 46,xy sex reversal 1 10.4
15 46 xy gonadal dysgenesis 10.4
16 malignant leydig cell tumor 10.3 KIT KRT7
17 necrotizing sialometaplasia 10.3 KIT KRT7
18 warthin tumor 10.3 KIT KRT7
19 prostate small cell carcinoma 10.3 ENO2 KIT
20 chondroid lipoma 10.3 ENO2 KRT7
21 breast adenomyoepithelioma 10.3 ENO2 KRT7
22 perivascular epithelioid cell tumor 10.3 KIT MUC1
23 breast myoepithelial neoplasm 10.3 ENO2 KRT7
24 sarcomatoid renal cell carcinoma 10.3 KIT MUC1
25 gastric squamous cell carcinoma 10.3 ENO2 KRT7
26 basaloid squamous cell carcinoma 10.3 ENO2 KRT7
27 lobular neoplasia 10.3 BRCA1 MUC1
28 gastric cardia carcinoma 10.3 KIT MUC1
29 adenomyoma 10.3 KRT7 MUC1
30 duodenal disease 10.3 KRT7 MUC1
31 spindle cell sarcoma 10.3 KRT7 MUC1
32 mucinous tubular and spindle renal cell carcinoma 10.3 KRT7 MUC1
33 ceruminoma 10.3 KIT KRT7
34 sclerosing hemangioma 10.3 KRT7 MUC1
35 lipoadenoma 10.3 KRT7 MUC1
36 monophasic synovial sarcoma 10.3 KRT7 MUC1
37 jejunal cancer 10.3 KIT KRT7
38 well-differentiated liposarcoma 10.3 KRT7 MUC1
39 jejunal adenocarcinoma 10.3 KRT20 KRT7
40 endocervical adenocarcinoma 10.3 KRT20 KRT7
41 immune system organ benign neoplasm 10.3 KRT20 KRT7
42 bladder lymphoma 10.3 KRT20 KRT7
43 chronic cystitis 10.3 KRT20 KRT7
44 eccrine sweat gland neoplasm 10.3 KRT20 KRT7
45 thymus lipoma 10.3 KRT20 KRT7
46 rectum adenocarcinoma 10.3 KRT20 KRT7
47 vulva adenocarcinoma 10.3 KRT20 KRT7
48 ovarian mucinous adenocarcinoma 10.3 KRT20 KRT7
49 bladder adenocarcinoma 10.3 KRT20 KRT7
50 infiltrative basal cell carcinoma 10.3 KRT20 KRT7

Graphical network of the top 20 diseases related to Dysgerminoma:



Diseases related to Dysgerminoma

Symptoms & Phenotypes for Dysgerminoma

MGI Mouse Phenotypes related to Dysgerminoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 AFP BRCA1 KIT PTHLH WT1

Drugs & Therapeutics for Dysgerminoma

Drugs for Dysgerminoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2
2
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
3
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
4
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
5
Ifosfamide Approved Phase 2 3778-73-2 3690
6
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
7
Tremelimumab Investigational Phase 2 745013-59-6
8 Hematinics Phase 2
9 Antineoplastic Agents, Alkylating Phase 2
10 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
11
Isophosphamide mustard Phase 2 0
12 Alkylating Agents Phase 2
13 Antimitotic Agents Phase 2,Phase 1
14 Albumin-Bound Paclitaxel Phase 2,Phase 1
15 Angiogenesis Modulating Agents Phase 2
16 Angiogenesis Inhibitors Phase 2
17 Protein Kinase Inhibitors Phase 2,Phase 1
18 Antibodies Phase 2
19 Immunoglobulins Phase 2
20 Immunologic Factors Phase 2
21 Antibodies, Monoclonal Phase 2
22 Imatinib Mesylate Phase 2 220127-57-1 123596
23 Chorionic Gonadotropin Phase 2
24
Lapatinib Approved March 2007, Investigational Phase 1 388082-78-8, 231277-92-2 208908 9941095

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Darbepoetin Alfa in Patients With "Poor Prognosis" Germ Cell Tumor Treated With High-Dose Chemotherapy (HD-VIP) Completed NCT00204633 Phase 2 Darbepoetin alfa
2 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
3 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
4 Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors Recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
5 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
6 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
7 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521

Search NIH Clinical Center for Dysgerminoma

Cochrane evidence based reviews: dysgerminoma

Genetic Tests for Dysgerminoma

Genetic tests related to Dysgerminoma:

# Genetic test Affiliating Genes
1 Dysgerminoma 29

Anatomical Context for Dysgerminoma

MalaCards organs/tissues related to Dysgerminoma:

41
Ovary, Lung, Breast, Myeloid, Kidney, Testis, Appendix

Publications for Dysgerminoma

Articles related to Dysgerminoma:

(show top 50) (show all 445)
# Title Authors Year
1
Unexpected diagnosis of stage IIA dysgerminoma in streak gonad in a patient with Swyer syndrome: a case report. ( 29084462 )
2018
2
Increased human Chorionic Gonadotropin levels five years before diagnosis of an ovarian dysgerminoma. ( 29150337 )
2018
3
Paediatric dysgerminoma: Results of three consecutive French germ cell tumours clinical studies (TGM-85/90/95) with late effects study. ( 29331749 )
2018
4
Imaging findings of ovarian dysgerminoma with emphasis on multiplicity and vascular architecture: pathogenic implications. ( 29450608 )
2018
5
Disparities in fertility-sparing surgery in adolescent and young women with stage I ovarian dysgerminoma. ( 29506849 )
2018
6
Ovarian dysgerminoma in pregnancy: A case report and literature review. ( 29580145 )
2018
7
Pseudopapillary and Macrofollicular Microscopic Growth Patterns in an Advanced Stage Ovarian Dysgerminoma: A Case Report. ( 29731802 )
2018
8
Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? ( 29884437 )
2018
9
Torsion of Ovarian Dysgerminoma in a Child: Role of Computed Tomography. ( 29942725 )
2018
10
Treatment of bilateral ovarian dysgerminoma with 11-year follow-up: A case report. ( 30186597 )
2018
11
Primary intrauterine dysgerminoma in a pregnant woman: A rare case report. ( 30303159 )
2018
12
Pediatric ovarian dysgerminoma with highly elevated serum neuron-specific enolase. ( 30345703 )
2018
13
Pitfalls of Frozen Section in Gynecological Pathology: A Rare Case of Ovarian Lymphoma in an HIV-Positive Woman Resembling Dysgerminoma on Frozen Section. ( 30474462 )
2018
14
Two Cases of Hypercalcemia in Pediatric Ovarian Dysgerminoma. ( 30551952 )
2018
15
Dysgerminoma and Gonadoblastoma with Para-aortic Lymph Node Metastasis in a Patient with Swyer Syndrome. ( 28748865 )
2017
16
Case Report: Use of Tumor and Germline Y Chromosomal Analysis to Guide Surgical Management in a 46, XX Female Presenting With Gonadoblastoma With Dysgerminoma. ( 28800577 )
2017
17
Complications of dysgerminoma: meeting the health needs of patients in conflict zones. ( 28137901 )
2017
18
Adolescent Female With Turner's Syndrome and 46,X,der(Y) del(Y)(p11.2)del(q11.2) Karyotype With Gonadoblastoma and Dysgerminoma. ( 29187016 )
2017
19
Ovarian dysgerminoma presenting as a pregnancy: case report. ( 27448792 )
2017
20
Dysgerminoma and gonadoblastoma in the course of Swyer syndrome. ( 28547971 )
2016
21
Unilateral gonadoblastoma with dysgerminoma in normal fertile woman having a child: Extremely rare occurrence with characteristic immunohistomorphology. ( 27721289 )
2016
22
Dual malignancy in adolescence: A rare case report of metachronous papillary carcinoma of thyroid following dysgerminoma of ovary. ( 27904567 )
2016
23
Dysgerminoma developing from an ectopic ovary in a patient with WAGR syndrome: A case report. ( 27882234 )
2016
24
Parinaud A<plusA> syndrome in a patient with dysgerminoma. ( 26900044 )
2016
25
Imaging Findings in Dysgerminoma in a Case of 46 XY, Complete Gonadal Dysgenesis (Swyer syndrome). ( 27790550 )
2016
26
Nevoid Basal Cell Carcinoma Syndrome and dysgerminoma: an incidental association? ( 26333390 )
2016
27
The role of mathematical models and scoring systems in detecting dysgerminoma in a young patient. ( 27723077 )
2016
28
Is fertility sparing surgery a treatment option for premenopausal patients with dysgerminoma? ( 28127973 )
2016
29
Death by bleomycin pulmonary toxicity in ovarian dysgerminoma with pathologic complete response to chemotherapy. A case report. ( 27330950 )
2016
30
Hemophagocytic lymphohistiocytosis as a paraneoplastic syndrome associated with ovarian dysgerminoma. ( 27354999 )
2016
31
An Incidental Finding of Bilateral Dysgerminoma During Cesarean Section: Dilemmas in Management. ( 27656514 )
2016
32
A case of swyer syndrome associated with advanced gonadal dysgerminoma involving long survival. ( 25960730 )
2015
33
PRESUMPTIVE DYSGERMINOMA IN AN ORANGE-SPOT FRESHWATER STINGRAY (POTAMOTRYGON MOTORO). ( 26056900 )
2015
34
Pelvic mass in a young woman with a background of ovarian dysgerminoma: differential diagnosis. ( 26578506 )
2015
35
Paraneoplastic Cholestasis Associated With Ovarian Dysgerminoma. ( 25923022 )
2015
36
Ovarian dysgerminoma with normal serum tumour markers presenting in a child with precocious puberty. ( 26458677 )
2015
37
Gonadoblastoma with Dysgerminoma in a Phenotypically Turner-Like Girl with 45,X/46,XY Karyotype. ( 26777047 )
2015
38
Dysgerminoma on a gonadoblastoma in a patient with Swyer syndrome treated with single incision laparoscopic surgery. ( 24960113 )
2014
39
46,XY female sex reversal syndrome with bilateral gonadoblastoma and dysgerminoma. ( 25187804 )
2014
40
Characterization of common marmoset dysgerminoma-like tumor induced by the lentiviral expression of reprogramming factors. ( 24521492 )
2014
41
Advanced ovarian dysgerminoma infiltrating both ovaries and uterus in a 7-year-old girl. ( 24716051 )
2014
42
Anti-Ma-associated encephalitis due to dysgerminoma in a woman with Swyer syndrome. ( 24711536 )
2014
43
Ovarian dysgerminoma in an adolescent: a case report. ( 24377208 )
2013
44
Anti-Ma-associated encephalitis due to dysgerminoma in a woman with Swyer syndrome. ( 23486885 )
2013
45
Novel mutation of the sex-determining region on the Y chromosome in a 46,XY female patient with monolateral dysgerminoma: a case report. ( 22889418 )
2013
46
Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1. ( 23618579 )
2013
47
Mediastinal mass following successful chemotherapy for ovary dysgerminoma: benign process or disease relapse? A case report. ( 23332198 )
2013
48
Ovarian Gonadoblastoma with Dysgerminoma in a Young Girl with 46, XX Karyotype: A Case Report. ( 24179931 )
2013
49
Ovarian dysgerminoma: a case report and literature review. ( 23929062 )
2013
50
Fine needle aspiration cytology of Sertoli-Leydig cell tumors of ovary masquerading as dysgerminoma. ( 22102529 )
2013

Variations for Dysgerminoma

ClinVar genetic disease variations for Dysgerminoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 KIT NM_000222.2(KIT): c.2447A> T (p.Asp816Val) single nucleotide variant Uncertain significance rs121913507 GRCh37 Chromosome 4, 55599321: 55599321
2 KIT NM_000222.2(KIT): c.2447A> T (p.Asp816Val) single nucleotide variant Uncertain significance rs121913507 GRCh38 Chromosome 4, 54733155: 54733155
3 KIT NM_000222.2(KIT): c.2446G> C (p.Asp816His) single nucleotide variant Pathogenic rs121913506 GRCh37 Chromosome 4, 55599320: 55599320
4 KIT NM_000222.2(KIT): c.2446G> C (p.Asp816His) single nucleotide variant Pathogenic rs121913506 GRCh38 Chromosome 4, 54733154: 54733154
5 BRCA1 NM_007294.3(BRCA1): c.1504_1508delTTAAA (p.Leu502Alafs) deletion Pathogenic rs80357888 GRCh37 Chromosome 17, 41246040: 41246044
6 BRCA1 NM_007294.3(BRCA1): c.1504_1508delTTAAA (p.Leu502Alafs) deletion Pathogenic rs80357888 GRCh38 Chromosome 17, 43094023: 43094027
7 KIT NM_000222.2(KIT): c.2850_2851insGT (p.Asp952Terfs) insertion other GRCh37 Chromosome 4, 55604642: 55604643
8 KIT NM_000222.2(KIT): c.2850_2851insGT (p.Asp952Terfs) insertion other GRCh38 Chromosome 4, 54738476: 54738477
9 SET NM_001122821.1(SET): c.814_815insA (p.Asp273Argfs) insertion other GRCh37 Chromosome 9, 131456287: 131456287
10 SET NM_001122821.1(SET): c.814_815insA (p.Asp273Argfs) insertion other GRCh38 Chromosome 9, 128694007: 128694008

Expression for Dysgerminoma

Search GEO for disease gene expression data for Dysgerminoma.

Pathways for Dysgerminoma

Pathways related to Dysgerminoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 AFP ALPP WT1

GO Terms for Dysgerminoma

Cellular components related to Dysgerminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.36 AFP BRCA1 ENO2 KIT KRT20 KRT7

Biological processes related to Dysgerminoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sex differentiation GO:0007548 9.16 SRY TSPY1
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 BRCA1 MUC1
3 positive regulation of male gonad development GO:2000020 8.62 SRY WT1

Sources for Dysgerminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....