MCID: DYS017
MIFTS: 41

Dysgerminoma of Ovary

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Dysgerminoma of Ovary

MalaCards integrated aliases for Dysgerminoma of Ovary:

Name: Dysgerminoma of Ovary 12 15 73
Ovarian Dysgerminoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5511
NCIt 50 C8106
UMLS 73 C0346185

Summaries for Dysgerminoma of Ovary

Disease Ontology : 12 A dysgerminoma that is located in the ovary.

MalaCards based summary : Dysgerminoma of Ovary, also known as ovarian dysgerminoma, is related to pediatric ovarian dysgerminoma and gonadoblastoma, and has symptoms including abdominal pain An important gene associated with Dysgerminoma of Ovary is LNPEP (Leucyl And Cystinyl Aminopeptidase), and among its related pathways/superpathways is Gastric cancer. The drugs Paclitaxel and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include ovary, lung and kidney, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Dysgerminoma of Ovary

Diseases related to Dysgerminoma of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 pediatric ovarian dysgerminoma 32.2 ALPP ENO2
2 gonadoblastoma 30.4 ALPP KIT WT1
3 dysgerminoma 30.1 AFP ALPP BRCA1 ENO2 KIT PTHLH
4 malignant dysgerminomatous germ cell tumor of the ovary 11.6
5 mixed hepatoblastoma 10.3 AFP PGR
6 pediatric ovarian germ cell tumor 10.3 ALPP ENO2
7 sclerosing hepatic carcinoma 10.3 AFP PTHLH
8 mixed germ cell tumor 10.3 AFP KIT
9 testicular gonadoblastoma 10.3 KIT WT1
10 malignant sertoli cell tumor 10.3 AFP ENO2
11 testicular malignant germ cell cancer 10.3 AFP ALPP
12 hereditary site-specific ovarian cancer syndrome 10.3 BRCA1 BRCA2
13 lung meningioma 10.3 ENO2 PGR
14 hepatic angiomyolipoma 10.3 AFP KIT
15 breast medullary carcinoma 10.2 BRCA1 PGR
16 breast reconstruction 10.2 BRCA1 BRCA2
17 tuberculous salpingitis 10.2 BRCA1 BRCA2
18 cutaneous ganglioneuroma 10.2 ENO2 KIT
19 endosalpingiosis 10.2 PGR WT1
20 kidney sarcoma 10.2 DICER1 WT1
21 endometrial small cell carcinoma 10.2 AFP ENO2 KIT
22 angiomyoma 10.2 ENO2 KIT PTHLH
23 deep leiomyoma 10.2 GFAP KIT
24 epulis 10.2 ENO2 PGR
25 testicular granulosa cell tumor 10.2 AFP DICER1 WT1
26 juvenile type testicular granulosa cell tumor 10.2 AFP DICER1 WT1
27 germ cell cancer 10.2 AFP ALPP KIT
28 male reproductive organ benign neoplasm 10.2 AFP DICER1 WT1
29 testicular germ cell tumor 10.2 AFP ALPP KIT
30 heart sarcoma 10.2 ENO2 KIT WT1
31 intracranial cysts 10.2 ENO2 GFAP
32 nosophobia 10.2 BRCA1 BRCA2 PGR
33 cancerophobia 10.2 BRCA1 BRCA2 PGR
34 mediastinal cancer 10.2 AFP CD79A KIT
35 intratubular embryonal carcinoma 10.2 AFP KIT
36 lymphoplasmacyte-rich meningioma 10.2 CD79A PGR
37 synchronous bilateral breast carcinoma 10.2 BRCA1 BRCA2 PGR
38 glycogen-rich clear cell breast carcinoma 10.2 BRCA1 BRCA2 PGR
39 clear cell sarcoma 10.2 ENO2 KIT WT1
40 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 GFAP
41 breast-ovarian cancer, familial 1 10.2 BRCA1 BRCA2
42 central nervous system germ cell tumor 10.2 AFP GFAP
43 gastric leiomyosarcoma 10.2 ENO2 KIT
44 peritoneum cancer 10.2 BRCA1 BRCA2 WT1
45 bilateral breast cancer 10.2 BRCA1 BRCA2 PGR
46 primary peritoneal carcinoma 10.2 BRCA1 BRCA2 PGR
47 fallopian tube carcinoma 10.2 BRCA1 BRCA2 PGR
48 breast carcinoma in situ 10.2 BRCA1 BRCA2 PGR
49 female breast cancer 10.2 BRCA1 BRCA2 PGR
50 c1q nephropathy 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Dysgerminoma of Ovary:



Diseases related to Dysgerminoma of Ovary

Symptoms & Phenotypes for Dysgerminoma of Ovary

UMLS symptoms related to Dysgerminoma of Ovary:


abdominal pain

GenomeRNAi Phenotypes related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.55 MAPK8IP1
2 Decreased viability GR00221-A-1 9.55 KIT
3 Decreased viability GR00221-A-2 9.55 BRCA1
4 Decreased viability GR00221-A-3 9.55 BRCA1
5 Decreased viability GR00221-A-4 9.55 MAPK8IP1
6 Decreased viability GR00301-A 9.55 BRCA1 FGFR2 KIT MAPK8IP1
7 Decreased viability GR00342-S-1 9.55 FGFR2
8 Decreased viability GR00342-S-2 9.55 FGFR2
9 Decreased viability GR00342-S-3 9.55 FGFR2 MAPK8IP1
10 Decreased viability GR00402-S-2 9.55 BRCA1 FGFR2 KIT MAPK8IP1

MGI Mouse Phenotypes related to Dysgerminoma of Ovary:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.45 AFP ANXA2 BRCA1 BRCA2 CD40LG CD79A
2 cellular MP:0005384 10.42 BRCA1 BRCA2 CD40LG CD79A DICER1 ENO2
3 behavior/neurological MP:0005386 10.4 AFP BRCA1 BRCA2 CALB2 DICER1 ENO2
4 endocrine/exocrine gland MP:0005379 10.37 AFP BRCA1 BRCA2 CD40LG DICER1 FGFR2
5 growth/size/body region MP:0005378 10.36 ANXA2 BRCA1 BRCA2 DICER1 ENO2 FGFR2
6 cardiovascular system MP:0005385 10.32 ANXA2 BRCA1 CD40LG DICER1 FGFR2 GFAP
7 immune system MP:0005387 10.29 BRCA1 BRCA2 CD40LG CD79A DICER1 FGFR2
8 hematopoietic system MP:0005397 10.28 ANXA2 BRCA1 BRCA2 CD40LG CD79A DICER1
9 mortality/aging MP:0010768 10.25 AFP BRCA1 BRCA2 CD40LG DICER1 FGFR2
10 nervous system MP:0003631 10.18 BRCA1 BRCA2 CALB2 CD40LG CD79A DICER1
11 digestive/alimentary MP:0005381 10.11 BRCA1 BRCA2 FGFR2 GFAP INSM1 KIT
12 integument MP:0010771 10.1 BRCA1 BRCA2 CD40LG DICER1 FGFR2 KIT
13 neoplasm MP:0002006 10.1 AFP BRCA1 BRCA2 CD79A DICER1 FGFR2
14 liver/biliary system MP:0005370 10.06 AFP CD79A DICER1 FGFR2 KIT MAPK8IP1
15 limbs/digits/tail MP:0005371 10.02 BRCA1 BRCA2 DICER1 FGFR2 KIT PGR
16 normal MP:0002873 10 BRCA1 BRCA2 CALB2 CD79A DICER1 FGFR2
17 no phenotypic analysis MP:0003012 9.92 CD79A DICER1 FGFR2 INSM1 KIT LNPEP
18 renal/urinary system MP:0005367 9.76 BRCA1 CD40LG CD79A DICER1 FGFR2 KIT
19 reproductive system MP:0005389 9.7 AFP BRCA1 BRCA2 CD40LG DICER1 FGFR2
20 respiratory system MP:0005388 9.23 BRCA1 DICER1 ENO2 FGFR2 INSM1 KIT

Drugs & Therapeutics for Dysgerminoma of Ovary

Drugs for Dysgerminoma of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
2
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
3
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
4
Ifosfamide Approved Phase 2 3778-73-2 3690
5
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
6 Antineoplastic Agents, Alkylating Phase 2
7 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
8
Isophosphamide mustard Phase 2 0
9 Alkylating Agents Phase 2
10 Antimitotic Agents Phase 2,Phase 1
11 Albumin-Bound Paclitaxel Phase 2,Phase 1
12 Angiogenesis Modulating Agents Phase 2
13 Angiogenesis Inhibitors Phase 2
14 Protein Kinase Inhibitors Phase 2,Phase 1
15 Imatinib Mesylate Phase 2 220127-57-1 123596
16 Chorionic Gonadotropin Phase 2
17
Lapatinib Approved March 2007, Investigational Phase 1 388082-78-8, 231277-92-2 208908 9941095

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
2 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
3 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
4 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
5 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521

Search NIH Clinical Center for Dysgerminoma of Ovary

Genetic Tests for Dysgerminoma of Ovary

Anatomical Context for Dysgerminoma of Ovary

MalaCards organs/tissues related to Dysgerminoma of Ovary:

41
Ovary, Lung, Kidney, Heart, Breast, Cervix, Testis

The Foundational Model of Anatomy Ontology organs/tissues related to Dysgerminoma of Ovary:

19
The Ovary

Publications for Dysgerminoma of Ovary

Articles related to Dysgerminoma of Ovary:

(show all 24)
# Title Authors Year
1
Increased human Chorionic Gonadotropin levels five years before diagnosis of an ovarian dysgerminoma. ( 29150337 )
2018
2
Imaging findings of ovarian dysgerminoma with emphasis on multiplicity and vascular architecture: pathogenic implications. ( 29450608 )
2018
3
Disparities in fertility-sparing surgery in adolescent and young women with stage I ovarian dysgerminoma. ( 29506849 )
2018
4
Ovarian dysgerminoma in pregnancy: A case report and literature review. ( 29580145 )
2018
5
Pseudopapillary and Macrofollicular Microscopic Growth Patterns in an Advanced Stage Ovarian Dysgerminoma: A Case Report. ( 29731802 )
2018
6
Torsion of Ovarian Dysgerminoma in a Child: Role of Computed Tomography. ( 29942725 )
2018
7
Treatment of bilateral ovarian dysgerminoma with 11-year follow-up: A case report. ( 30186597 )
2018
8
Pediatric ovarian dysgerminoma with highly elevated serum neuron-specific enolase. ( 30345703 )
2018
9
Two Cases of Hypercalcemia in Pediatric Ovarian Dysgerminoma. ( 30551952 )
2018
10
Ovarian dysgerminoma presenting as a pregnancy: case report. ( 27448792 )
2017
11
Dual malignancy in adolescence: A rare case report of metachronous papillary carcinoma of thyroid following dysgerminoma of ovary. ( 27904567 )
2016
12
Death by bleomycin pulmonary toxicity in ovarian dysgerminoma with pathologic complete response to chemotherapy. A case report. ( 27330950 )
2016
13
Hemophagocytic lymphohistiocytosis as a paraneoplastic syndrome associated with ovarian dysgerminoma. ( 27354999 )
2016
14
Internal hemorrhage caused by a twisted malignant ovarian dysgerminoma: ultrasonographic findings of a rare case and review of the literature. ( 14998196 )
2004
15
Ovarian dysgerminoma presenting with hypercalcaemia. ( 11843397 )
2001
16
Primary ovarian dysgerminoma in a patient with a germline BRCA1 mutation. ( 11109172 )
2000
17
Advanced ovarian dysgerminoma with cure of tumor persistent in meninges. ( 2722068 )
1989
18
A clinical review of seventeen patients with ovarian dysgerminoma. ( 7153081 )
1982
19
Human chorionic gonadotrophin secretion in dysgerminoma of ovary. ( 497102 )
1979
20
A review of thirty-three cases of ovarian dysgerminoma emphasising the role of radiotherapy. ( 466963 )
1979
21
Ovarian dysgerminoma associated with masculinization. ( 13356255 )
1956
22
Ovarian dysgerminoma and pregnancy. ( 13238480 )
1955
23
An unusual case of precocious puberty associated with ovarian dysgerminoma. ( 15399552 )
1949
24
Dysgerminoma of ovary. ( 20271732 )
1947

Variations for Dysgerminoma of Ovary

Expression for Dysgerminoma of Ovary

Search GEO for disease gene expression data for Dysgerminoma of Ovary.

Pathways for Dysgerminoma of Ovary

Pathways related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.69 BRCA1 BRCA2 FGFR2 KIT PGR

GO Terms for Dysgerminoma of Ovary

Cellular components related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 AFP ANXA2 BRCA1 BRCA2 CALB2 DICER1
2 lateral element GO:0000800 8.96 BRCA1 BRCA2

Biological processes related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.77 CD40LG FGFR2 KIT MAPK8IP1 WT1
2 cell-cell signaling GO:0007267 9.46 FGFR2 LNPEP PGR PTHLH
3 regulation of protein complex assembly GO:0043254 9.32 GFAP INSM1
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.26 BRCA1 BRCA2
5 ovulation from ovarian follicle GO:0001542 8.96 AFP PGR
6 chordate embryonic development GO:0043009 8.62 BRCA1 BRCA2

Molecular functions related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.7 AFP ALPP BRCA1 CALB2 DICER1 ENO2
2 protein binding GO:0005515 9.55 AFP ALPP ANXA2 BRCA1 BRCA2 CD40LG
3 protease binding GO:0002020 9.33 ANXA2 BRCA2 KIT

Sources for Dysgerminoma of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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