MCID: DYS017
MIFTS: 37

Dysgerminoma of Ovary

Categories: Endocrine diseases, Reproductive diseases, Cancer diseases

Aliases & Classifications for Dysgerminoma of Ovary

MalaCards integrated aliases for Dysgerminoma of Ovary:

Name: Dysgerminoma of Ovary 12 15 73
Ovarian Dysgerminoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5511
NCIt 50 C8106
SNOMED-CT 68 254874008
UMLS 73 C0346185

Summaries for Dysgerminoma of Ovary

Disease Ontology : 12 A dysgerminoma that is located in the ovary.

MalaCards based summary : Dysgerminoma of Ovary, also known as ovarian dysgerminoma, is related to pediatric ovarian dysgerminoma and pediatric ovarian germ cell tumor, and has symptoms including abdominal pain An important gene associated with Dysgerminoma of Ovary is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways is Gastric cancer. The drugs Cisplatin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include the ovary, ovary and brain, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Dysgerminoma of Ovary

Diseases related to Dysgerminoma of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 pediatric ovarian dysgerminoma 33.0 ALPP ENO2
2 pediatric ovarian germ cell tumor 11.0 ALPP ENO2
3 testicular malignant germ cell cancer 10.9 AFP ALPP
4 sclerosing hepatic carcinoma 10.9 AFP PTHLH
5 malignant sertoli cell tumor 10.9 AFP ENO2
6 mixed germ cell tumor 10.9 AFP KIT
7 mixed hepatoblastoma 10.9 AFP PGR
8 hepatic angiomyolipoma 10.9 AFP KIT
9 testicular gonadoblastoma 10.9 KIT WT1
10 cutaneous ganglioneuroma 10.9 ENO2 KIT
11 lung meningioma 10.8 ENO2 PGR
12 breast medullary carcinoma 10.8 BRCA1 PGR
13 gastric leiomyosarcoma 10.8 ENO2 KIT
14 epulis 10.8 ENO2 PGR
15 cribriform carcinoma 10.8 KIT PGR
16 malignant mixed mullerian tumor 10.8 KIT PGR
17 benign breast phyllodes tumor 10.8 KIT PGR
18 hereditary site-specific ovarian cancer syndrome 10.8 BRCA1 BRCA2
19 intratubular embryonal carcinoma 10.8 AFP KIT
20 endosalpingiosis 10.8 PGR WT1
21 female reproductive endometrioid cancer 10.7 PGR WT1
22 pleomorphic adenoma carcinoma 10.7 ENO2 PTHLH
23 breast reconstruction 10.7 BRCA1 BRCA2
24 adenoid basal cell carcinoma 10.7 KIT PGR
25 tuberculous salpingitis 10.7 BRCA1 BRCA2
26 kidney sarcoma 10.7 DICER1 WT1
27 sarcomatoid squamous cell skin carcinoma 10.7 KIT MAPK8IP1
28 ovarian small cell carcinoma 10.7 PTHLH WT1
29 kidney rhabdoid cancer 10.7 ENO2 WT1
30 angiomyoma 10.7 ENO2 KIT PTHLH
31 uterine corpus serous adenocarcinoma 10.7 BRCA1 BRCA2
32 endometrial small cell carcinoma 10.7 AFP ENO2 KIT
33 cauda equina neoplasm 10.7 ENO2 WT1
34 deep leiomyoma 10.7 GFAP KIT
35 breast angiosarcoma 10.6 KIT PGR
36 malignant teratoma 10.6 AFP ENO2
37 gonadoblastoma 10.6 ALPP KIT WT1
38 intracranial cysts 10.6 ENO2 GFAP
39 epithelioid cell melanoma 10.6 ENO2 WT1
40 primitive neuroectodermal tumor of the cervix uteri 10.6 ENO2 GFAP
41 breast-ovarian cancer, familial 1 10.6 BRCA1 BRCA2
42 central nervous system germ cell tumor 10.6 AFP GFAP
43 liver sarcoma 10.6 AFP PTHLH
44 mixed cell type cancer 10.6 ENO2 KIT PGR
45 heart sarcoma 10.6 ENO2 KIT WT1
46 ocular melanoma 10.6 BRCA2 KIT
47 organ system benign neoplasm 10.6 ENO2 KIT PGR
48 cerebellar medulloblastoma 10.6 ENO2 GFAP
49 clear cell sarcoma 10.6 ENO2 KIT WT1
50 subependymal glioma 10.5 ENO2 GFAP

Graphical network of the top 20 diseases related to Dysgerminoma of Ovary:



Diseases related to Dysgerminoma of Ovary

Symptoms & Phenotypes for Dysgerminoma of Ovary

UMLS symptoms related to Dysgerminoma of Ovary:


abdominal pain

GenomeRNAi Phenotypes related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.55 MAPK8IP1
2 Decreased viability GR00221-A-1 9.55 KIT
3 Decreased viability GR00221-A-2 9.55 BRCA1
4 Decreased viability GR00221-A-3 9.55 BRCA1
5 Decreased viability GR00221-A-4 9.55 MAPK8IP1
6 Decreased viability GR00301-A 9.55 FGFR2 KIT MAPK8IP1 BRCA1
7 Decreased viability GR00342-S-1 9.55 FGFR2
8 Decreased viability GR00342-S-2 9.55 FGFR2
9 Decreased viability GR00342-S-3 9.55 FGFR2 MAPK8IP1
10 Decreased viability GR00402-S-2 9.55 FGFR2 KIT MAPK8IP1 BRCA1

MGI Mouse Phenotypes related to Dysgerminoma of Ovary:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.38 AFP CALB2 BRCA1 DICER1 BRCA2 ENO2
2 homeostasis/metabolism MP:0005376 10.37 ANXA2 BRCA1 DICER1 BRCA2 AFP INSM1
3 cellular MP:0005384 10.33 BRCA2 BRCA1 DICER1 ENO2 INSM1 FGFR2
4 growth/size/body region MP:0005378 10.32 ANXA2 BRCA1 DICER1 BRCA2 ENO2 INSM1
5 endocrine/exocrine gland MP:0005379 10.3 BRCA1 DICER1 BRCA2 AFP INSM1 FGFR2
6 cardiovascular system MP:0005385 10.26 ANXA2 BRCA1 DICER1 FGFR2 KIT GFAP
7 mortality/aging MP:0010768 10.21 AFP BRCA2 BRCA1 DICER1 GFAP INSM1
8 immune system MP:0005387 10.18 BRCA2 BRCA1 DICER1 WT1 GFAP FGFR2
9 digestive/alimentary MP:0005381 10.08 BRCA2 BRCA1 GFAP INSM1 FGFR2 PTHLH
10 nervous system MP:0003631 10.06 BRCA2 CALB2 BRCA1 DICER1 ENO2 INSM1
11 limbs/digits/tail MP:0005371 10 BRCA2 BRCA1 DICER1 FGFR2 KIT PTHLH
12 neoplasm MP:0002006 9.97 AFP BRCA1 DICER1 BRCA2 FGFR2 KIT
13 muscle MP:0005369 9.95 BRCA1 WT1 GFAP FGFR2 DICER1 KIT
14 normal MP:0002873 9.81 BRCA2 CALB2 BRCA1 DICER1 FGFR2 KIT
15 no phenotypic analysis MP:0003012 9.8 DICER1 WT1 INSM1 FGFR2 LNPEP PGR
16 reproductive system MP:0005389 9.65 BRCA2 AFP BRCA1 DICER1 FGFR2 KIT
17 respiratory system MP:0005388 9.23 BRCA1 DICER1 ENO2 INSM1 FGFR2 KIT

Drugs & Therapeutics for Dysgerminoma of Ovary

Drugs for Dysgerminoma of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
3
Ifosfamide Approved Phase 2 3778-73-2 3690
4
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
5
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
6
Isophosphamide mustard Phase 2 0
7 Alkylating Agents Phase 2
8 Albumin-Bound Paclitaxel Phase 2,Phase 1
9 Angiogenesis Inhibitors Phase 2
10 Angiogenesis Modulating Agents Phase 2
11 Protein Kinase Inhibitors Phase 2,Phase 1
12 Antimitotic Agents Phase 2,Phase 1
13 Antineoplastic Agents, Alkylating Phase 2
14 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
15 Imatinib Mesylate Phase 2 220127-57-1 123596
16 Chorionic Gonadotropin Phase 2
17
Lapatinib Approved March 2007, Investigational Phase 1 231277-92-2, 388082-78-8 208908 9941095

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
2 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
3 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
4 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
5 Changes in Brain Function in Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Who Are Receiving Chemotherapy Completed NCT01080521

Search NIH Clinical Center for Dysgerminoma of Ovary

Genetic Tests for Dysgerminoma of Ovary

Anatomical Context for Dysgerminoma of Ovary

The Foundational Model of Anatomy Ontology organs/tissues related to Dysgerminoma of Ovary:

19
The Ovary

MalaCards organs/tissues related to Dysgerminoma of Ovary:

41
Ovary, Brain, Thyroid

Publications for Dysgerminoma of Ovary

Articles related to Dysgerminoma of Ovary:

# Title Authors Year
1
Dual malignancy in adolescence: A rare case report of metachronous papillary carcinoma of thyroid following dysgerminoma of ovary. ( 27904567 )
2016
2
Human chorionic gonadotrophin secretion in dysgerminoma of ovary. ( 497102 )
1979
3
Dysgerminoma of ovary. ( 20271732 )
1947

Variations for Dysgerminoma of Ovary

Expression for Dysgerminoma of Ovary

Search GEO for disease gene expression data for Dysgerminoma of Ovary.

Pathways for Dysgerminoma of Ovary

Pathways related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.69 BRCA1 BRCA2 FGFR2 KIT PGR

GO Terms for Dysgerminoma of Ovary

Cellular components related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 AFP ANXA2 BRCA1 BRCA2 CALB2 DICER1
2 lateral element GO:0000800 8.96 BRCA1 BRCA2

Biological processes related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.62 FGFR2 LNPEP PGR PTHLH
2 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.26 BRCA1 BRCA2
3 regulation of protein complex assembly GO:0043254 9.16 GFAP INSM1
4 ovulation from ovarian follicle GO:0001542 8.96 AFP PGR
5 chordate embryonic development GO:0043009 8.62 BRCA1 BRCA2

Molecular functions related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.36 AFP ALPP BRCA1 CALB2 DICER1 ENO2
2 protease binding GO:0002020 9.33 ANXA2 BRCA2 KIT
3 mitogen-activated protein kinase kinase binding GO:0031434 9.13 FGFR2 KIT MAPK8IP1

Sources for Dysgerminoma of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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