MCID: DYS017
MIFTS: 37

Dysgerminoma of Ovary

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Dysgerminoma of Ovary

MalaCards integrated aliases for Dysgerminoma of Ovary:

Name: Dysgerminoma of Ovary 12 15 70
Ovarian Dysgerminoma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5511
NCIt 50 C8106
SNOMED-CT 67 254874008
UMLS 70 C0346185

Summaries for Dysgerminoma of Ovary

Disease Ontology : 12 A dysgerminoma that is located in the ovary.

MalaCards based summary : Dysgerminoma of Ovary, also known as ovarian dysgerminoma, is related to pediatric ovarian dysgerminoma and ovarian germ cell cancer, and has symptoms including abdominal pain An important gene associated with Dysgerminoma of Ovary is MIR371A (MicroRNA 371a), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Sunitinib and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and bone marrow, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Related Diseases for Dysgerminoma of Ovary

Diseases related to Dysgerminoma of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 pediatric ovarian dysgerminoma 32.1 PTHLH ALPP
2 ovarian germ cell cancer 30.6 KIT AFP
3 mixed germ cell tumor 30.6 KIT AFP
4 endodermal sinus tumor 30.2 MIR371A ALPP AFP
5 gonadoblastoma 30.1 POU5F1 KIT ALPP
6 central nervous system germinoma 29.9 POU5F1 ALPP
7 testicular germ cell tumor 29.9 MIR371A KITLG KIT AFP
8 brain germinoma 29.8 POU5F1 KIT AFP
9 germinoma 29.7 POU5F1 MIR371A KIT ALPP AFP
10 dysgerminoma 29.5 RNF139 PTHLH MIR371A KITLG KIT ALPP
11 seminoma 29.5 POU5F1 NANOG KIT ALPP AFP
12 spermatocytoma 29.2 POU5F1 NANOG MIR371A KIT AFP
13 embryonal carcinoma 29.2 POU5F1 NANOG KIT AFP
14 skin carcinoma 28.9 PTHLH POU5F1 KITLG KIT
15 germ cell cancer 28.4 POU5F1 NANOG MIR371A KITLG KIT ALPP
16 malignant dysgerminomatous germ cell tumor of the ovary 11.2
17 germ cells tumors 10.4
18 extragonadal seminoma 10.3 KIT AFP
19 pineal region teratoma 10.3 KIT AFP
20 childhood endodermal sinus tumor 10.3 MIR371A AFP
21 gallbladder leiomyosarcoma 10.3 KIT AFP
22 liver leiomyoma 10.3 KIT AFP
23 esophageal adenoid cystic carcinoma 10.3 KIT AFP
24 ovarian mixed germ cell neoplasm 10.3 KIT AFP
25 extracutaneous mastocytoma 10.3 KITLG KIT
26 sarcomatous intrahepatic cholangiocarcinoma 10.3 KIT AFP
27 cutaneous solitary mastocytoma 10.3 KITLG KIT
28 endometrial small cell carcinoma 10.3 KIT AFP
29 liver leiomyosarcoma 10.3 KIT AFP
30 sclerosing hepatic carcinoma 10.3 PTHLH AFP
31 pediatric germ cell cancer 10.3 MIR371A AFP
32 sm-ahnmd 10.3 KITLG KIT
33 testicular fibroma 10.3 KITLG AFP
34 mast-cell sarcoma 10.3 KITLG KIT
35 mediastinal cancer 10.2 KIT AFP
36 lung leiomyosarcoma 10.2 KITLG KIT
37 seminal vesicle adenocarcinoma 10.2 KIT AFP
38 pediatric ovarian germ cell tumor 10.2 PTHLH ALPP
39 dowling-degos disease 1 10.2 KITLG KIT
40 waardenburg syndrome, type 4b 10.2 KITLG KIT
41 indolent systemic mastocytosis 10.2 KITLG KIT
42 pancreatic endocrine carcinoma 10.2 PTHLH AFP
43 tietz albinism-deafness syndrome 10.2 KITLG KIT
44 hydrocele 10.2 MIR371A AFP
45 hepatic tuberculosis 10.1 ALPP AFP
46 rare tumor 10.1
47 mixed cell type cancer 10.1 KIT AFP
48 pediatric testicular germ cell tumor 10.1 POU5F1 AFP
49 ovarian embryonal carcinoma 10.1 POU5F1 AFP
50 ovarian primitive germ cell tumor 10.1 POU5F1 AFP

Graphical network of the top 20 diseases related to Dysgerminoma of Ovary:



Diseases related to Dysgerminoma of Ovary

Symptoms & Phenotypes for Dysgerminoma of Ovary

UMLS symptoms related to Dysgerminoma of Ovary:


abdominal pain

MGI Mouse Phenotypes related to Dysgerminoma of Ovary:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 AFP KIT KITLG LNPEP POU5F1 PTHLH
2 liver/biliary system MP:0005370 9.43 AFP KIT KITLG POU5F1 PTHLH RNF139
3 reproductive system MP:0005389 9.17 AFP KIT KITLG LNPEP POU5F1 PTHLH

Drugs & Therapeutics for Dysgerminoma of Ovary

Drugs for Dysgerminoma of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Ifosfamide Approved Phase 2 3778-73-2 3690
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5 Angiogenesis Inhibitors Phase 2
6 Tubulin Modulators Phase 2
7 Alkylating Agents Phase 2
8 Antimitotic Agents Phase 2
9 Albumin-Bound Paclitaxel Phase 2
10
Isophosphamide mustard Phase 2 100427
11 Protein Kinase Inhibitors Phase 2
12 Imatinib Mesylate Phase 2 220127-57-1 123596
13 Chorionic Gonadotropin Phase 2
14
Lapatinib Approved, Investigational Phase 1 231277-92-2, 388082-78-8 208908 9941095

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
2 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
3 A Phase II Study Of Imatinib Mesylate (Gleevec, Formerly Known As STI571; IND 61,135, NSC #716051) In Patients With Refractory Seminoma Terminated NCT00042952 Phase 2 imatinib mesylate
4 A Phase I Dose Escalation Study of a 2 Day Oral Lapatinib Chemosensitization Pulse Given Prior To Weekly Intravenous Abraxane™ in Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel

Search NIH Clinical Center for Dysgerminoma of Ovary

Genetic Tests for Dysgerminoma of Ovary

Anatomical Context for Dysgerminoma of Ovary

The Foundational Model of Anatomy Ontology organs/tissues related to Dysgerminoma of Ovary:

19
Ovary

MalaCards organs/tissues related to Dysgerminoma of Ovary:

40
Ovary, Uterus, Bone Marrow, Lymph Node, Placenta

Publications for Dysgerminoma of Ovary

Articles related to Dysgerminoma of Ovary:

(show top 50) (show all 257)
# Title Authors PMID Year
1
Ovarian Dysgerminoma in Pregnant Women with Viable Fetus: A Rare Case Report. 61
33776695 2021
2
Dysgerminoma with a Somatic Exon 17 KIT Mutation and SHH Pathway Activation in a Girl with Turner Syndrome. 61
33321690 2020
3
Ovarian dysgerminoma detected by 18F-FDG PET/CT technique: A case report. 61
33157971 2020
4
An aggressive systemic mastocytosis preceded by ovarian dysgerminoma. 61
33246418 2020
5
Pregnancy with giant ovarian dysgerminoma: A case report and literature review. 61
33031254 2020
6
Ovarian Dysgerminoma: A Tertiary Center Experience. 61
32762565 2020
7
Pure dysgerminoma of the ovary: CT and MRI features with pathological correlation in 13 tumors. 61
32552845 2020
8
Cervical lymph node metastasis of ovarian dysgerminoma: A case report with fine needle aspiration cytology. 61
31886634 2020
9
Late Recurrence in Ovarian Dysgerminoma Presenting as a Primary Retroperitoneal Tumor: A Case Report and Review of the Literature. 61
32110457 2020
10
Ovarian dysgerminoma with Müllerian anomaly: a case report. 61
31970134 2020
11
Role of optimal cytoreduction in patients with dysgerminoma. 61
31594835 2019
12
Cranial and intra-axial metastasis originating from a primary ovarian Dysgerminoma. 61
31317066 2019
13
Outcome of Metastatic and Recurrent Ovarian Dysgerminoma Using Radiation Therapy and Chemotherapy in a Dog. 61
31099610 2019
14
Two Cases of Hypercalcemia in Pediatric Ovarian Dysgerminoma. 61
30551952 2019
15
Pediatric ovarian dysgerminoma with highly elevated serum neuron-specific enolase. 61
30345703 2018
16
Treatment of bilateral ovarian dysgerminoma with 11-year follow-up: A case report. 61
30186597 2018
17
Ovarian dysgerminoma in pregnancy: A case report and literature review. 61
29580145 2018
18
Imaging findings of ovarian dysgerminoma with emphasis on multiplicity and vascular architecture: pathogenic implications. 61
29450608 2018
19
Disparities in fertility-sparing surgery in adolescent and young women with stage I ovarian dysgerminoma. 61
29506849 2018
20
Torsion of Ovarian Dysgerminoma in a Child: Role of Computed Tomography. 61
29942725 2018
21
Increased human Chorionic Gonadotropin levels five years before diagnosis of an ovarian dysgerminoma. 61
29150337 2018
22
Pseudopapillary and Macrofollicular Microscopic Growth Patterns in an Advanced Stage Ovarian Dysgerminoma: A Case Report. 61
29731802 2018
23
A retrospective pathology study of two Neotropical deer species (1995-2015), Brazil: Marsh deer (Blastocerus dichotomus) and brown brocket deer (Mazama gouazoubira). 61
29879222 2018
24
Ovarian dysgerminoma presenting as a pregnancy: case report. 61
27448792 2017
25
Hemophagocytic lymphohistiocytosis as a paraneoplastic syndrome associated with ovarian dysgerminoma. 61
27354999 2016
26
Hyper IgM Syndrome: a Report from the USIDNET Registry. 61
27189378 2016
27
Expression and mutation of c-Kit in intracranial germ cell tumors: A single-centre retrospective study of 30 cases in China. 61
27123048 2016
28
Dual malignancy in adolescence: A rare case report of metachronous papillary carcinoma of thyroid following dysgerminoma of ovary. 61
27904567 2016
29
Death by bleomycin pulmonary toxicity in ovarian dysgerminoma with pathologic complete response to chemotherapy. A case report. 61
27330950 2016
30
Pelvic mass in a young woman with a background of ovarian dysgerminoma: differential diagnosis. 61
26578506 2015
31
Fertility Preservation Through Oocyte Cryopreservation in a Patient with Ovarian Dysgerminocarcinoma: A Case Report. 61
26592073 2015
32
Paraneoplastic Cholestasis Associated With Ovarian Dysgerminoma. 61
25923022 2015
33
Ovarian dysgerminoma with normal serum tumour markers presenting in a child with precocious puberty. 61
26458677 2015
34
A case of swyer syndrome associated with advanced gonadal dysgerminoma involving long survival. 61
25960730 2015
35
Ovarian germinoma accelerating the presentation of diabetes mellitus. 61
25171445 2015
36
[Ovarian germ cell tumors in girls]. 61
26087605 2015
37
Elevated human chorionic gonadotropin and hyperandrogenemia in a woman with Müllerian agenesis. 61
24413227 2014
38
In vitro assessment of antitumor activities of the PI3K/mTOR inhibitor GSK2126458. 61
25298748 2014
39
Advanced ovarian dysgerminoma infiltrating both ovaries and uterus in a 7-year-old girl. 61
24716051 2014
40
Pediatric ovarian dysgerminoma presenting with hypercalcemia and chronic constipation: a case report. 61
23799522 2013
41
Current controversies in the management of germ cell ovarian tumours. 61
23942298 2013
42
Ovarian dysgerminoma: a case report and literature review. 61
23929062 2013
43
Burkitt lymphoma of the ovary: a case report and literature review. 61
23800271 2013
44
Bleomycin-induced flagellate hyperpigmentation. 61
23744859 2013
45
Ovarian dysgerminoma in an adolescent: a case report. 61
24377208 2013
46
Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1. 61
23618579 2013
47
Mediastinal mass following successful chemotherapy for ovary dysgerminoma: benign process or disease relapse? A case report. 61
23332198 2013
48
Pure dysgerminoma of the ovary: a single institutional experience of 65 patients. 61
22407668 2012
49
Ovarian dysgerminoma and synchronic contralateral tubal pregnancy followed by normal intra-uterine gestation: a case report. 61
23176153 2012
50
A pelvic mass on ultrasonography and high human chorionic gonadotropin level: not always an ectopic pregnancy. 61
22669919 2012

Variations for Dysgerminoma of Ovary

Expression for Dysgerminoma of Ovary

Search GEO for disease gene expression data for Dysgerminoma of Ovary.

Pathways for Dysgerminoma of Ovary

GO Terms for Dysgerminoma of Ovary

Biological processes related to Dysgerminoma of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.56 YBX2 PTHLH POU5F1 NANOG
2 embryonic hemopoiesis GO:0035162 9.32 KITLG KIT
3 ectopic germ cell programmed cell death GO:0035234 9.16 KITLG KIT
4 somatic stem cell population maintenance GO:0035019 9.13 POU5F1 NANOG KIT
5 endodermal cell fate specification GO:0001714 8.62 POU5F1 NANOG

Sources for Dysgerminoma of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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