MCID: DYS003
MIFTS: 36

Dysgraphia

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Dysgraphia

Summaries for Dysgraphia

NINDS : 53 Dysgraphia is a neurological disorder characterized by writing disabilities. Specifically, the disorder causes a person's writing to be distorted or incorrect. In children, the disorder generally emerges when they are first introduced to writing. They make inappropriately sized and spaced letters, or write wrong or misspelled words, despite thorough instruction. Children with the disorder may have other learning disabilities; however, they usually have no social or other academic problems. Cases of dysgraphia in adults generally occur after some trauma. In addition to poor handwriting, dysgraphia is characterized by wrong or odd spelling, and production of words that are not correct (i.e., using "boy" for "child"). The cause of the disorder is unknown, but in adults, it is usually associated with damage to the parietal lobe of the brain.

MalaCards based summary : Dysgraphia, also known as agraphia, is related to gerstmann syndrome and semantic dementia, and has symptoms including scanning speech and other symbolic dysfunction. An important gene associated with Dysgraphia is CELF4 (CUGBP Elav-Like Family Member 4). The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, parietal lobe and cortex, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper.

Wikipedia : 74 Dysgraphia is a deficiency in the ability to write, primarily handwriting, but also coherence.... more...

Related Diseases for Dysgraphia

Diseases related to Dysgraphia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 gerstmann syndrome 32.9 MAPT CBSL
2 semantic dementia 31.9 TARDBP MAPT GRN CHMP2B C9orf72
3 inclusion body myopathy with paget disease of bone and frontotemporal dementia 31.9 TARDBP CHMP2B C9orf72
4 progressive non-fluent aphasia 31.8 MAPT GRN CHMP2B C9orf72
5 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 31.0 MAPT GRN
6 apraxia 30.9 MAPT GRN C9orf72
7 anosognosia 30.8 CBSL C9orf72
8 alexia 30.7 MAPT GRN CBSL
9 visual agnosia 30.7 MAPT GRN CBSL
10 corticobasal degeneration 30.6 TARDBP MAPT
11 simultanagnosia 30.5 MAPT CBSL
12 finger agnosia 30.5 MAPT CBSL
13 prosopagnosia 30.4 TARDBP MAPT GRN
14 ideomotor apraxia 30.3 TARDBP MAPT GRN CBSL
15 agraphia 30.2 TARDBP MAPT GRN CBSL C9orf72
16 lateral sclerosis 30.1 TARDBP CHMP2B C9orf72
17 aphasia 30.0 TARDBP MAPT GRN CHMP2B CBSL C9orf72
18 dyscalculia 30.0 TARDBP GRN DNAAF4 CHMP2B CBSL
19 nominal aphasia 30.0 TARDBP MAPT GRN CHMP2B CBSL C9orf72
20 dementia 30.0 TARDBP MAPT GRN CHMP2B C9orf72
21 mutism 29.9 MAPT GRN CHMP2B C9orf72
22 frontotemporal dementia 29.8 TARDBP MAPT GRN CHMP2B C9orf72
23 movement disease 29.6 TARDBP MAPT GRN CBSL C9orf72
24 motor neuron disease 29.6 TARDBP MAPT GRN C9orf72
25 supranuclear palsy, progressive, 1 29.0 TARDBP MAPT GRN CHMP2B CBSL C9orf72
26 pick disease of brain 29.0 TARDBP MAPT GRN CHMP2B CBSL C9orf72
27 speech and communication disorders 28.7 TARDBP MAPT GRN DNAAF4 CHMP2B CELF4
28 writing disorder 28.1 TARDBP MAPT LINC00159 HYPK GRN DNAAF4
29 dyslexia 10.9
30 gait apraxia 10.4 GRN CBSL
31 yemenite deaf-blind hypopigmentation syndrome 10.4
32 alzheimer disease 10.3
33 learning disability 10.3
34 developmental coordination disorder 10.3
35 amyotrophic lateral sclerosis 1 10.3
36 hemiplegia 10.3
37 amyotrophic lateral sclerosis type 15 10.3 CHMP2B C9orf72
38 stroke, ischemic 10.3
39 developmental dyspraxia 10.3
40 specific language disorder 10.3
41 amyotrophic lateral sclerosis type 14 10.3 CHMP2B C9orf72
42 amyotrophic lateral sclerosis type 22 10.2 TARDBP C9orf72
43 amyotrophic lateral sclerosis 16, juvenile 10.2 CHMP2B C9orf72
44 ataxia and polyneuropathy, adult-onset 10.2
45 amusia 10.2
46 glioma 10.2
47 glial tumor 10.2
48 hand skill, relative 10.2
49 subacute delirium 10.2
50 tremor 10.2

Graphical network of the top 20 diseases related to Dysgraphia:



Diseases related to Dysgraphia

Symptoms & Phenotypes for Dysgraphia

UMLS symptoms related to Dysgraphia:


scanning speech, other symbolic dysfunction

MGI Mouse Phenotypes related to Dysgraphia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 ABCB10 C9orf72 CBSL CELF4 DNAAF4 ELP1
2 hematopoietic system MP:0005397 9.97 ABCB10 C9orf72 CBSL DNAAF4 ELP1 GRN
3 immune system MP:0005387 9.91 C9orf72 CBSL CELF4 DNAAF4 ELP1 GRN
4 mortality/aging MP:0010768 9.9 ABCB10 C9orf72 CBSL CELF4 CHMP2B DNAAF4
5 nervous system MP:0003631 9.65 C9orf72 CBSL CELF4 CHMP2B DDO DNAAF4
6 vision/eye MP:0005391 9.17 CBSL CELF4 CHMP2B ELP1 GRN LSS

Drugs & Therapeutics for Dysgraphia

Drugs for Dysgraphia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved 1401-55-4
2
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Handwriting Intervention, With vs. Without a Rightward Bias, in a Junior High School-A Randomized Controlled Study Completed NCT03903614
2 The Center for the Neurobiology of Language Recovery (CNLR) Completed NCT01927302
3 Effectiveness of a Handwriting Intervention With At-Risk Kindergarteners Completed NCT02620098
4 The Effects of a Graphomotor Intervention Program According to a Psychomotor Approach on Quality and Speed of Handwriting in School-Age Children: A Randomized Controlled Trial Completed NCT03699800
5 The Effects of a Graphomotor Intervention Program According to a Psychomotor Approach on Graphomotor Competences in Preschool Children: A Randomized Controlled Trial Completed NCT03699787
6 Improving Electronic Written Communication in Persons With Aphasia: A Clinical Trial Recruiting NCT03773419
7 Treatment for Reading and Writing Deficits Following Acquired Brain Injury Enrolling by invitation NCT03662243
8 Assessing the Generalizability of the Tachidino Protocol for Intervention on Reading and Spelling Disorders to Different Clinical Contexts Not yet recruiting NCT04384718

Search NIH Clinical Center for Dysgraphia

Cochrane evidence based reviews: agraphia

Genetic Tests for Dysgraphia

Anatomical Context for Dysgraphia

MalaCards organs/tissues related to Dysgraphia:

40
Brain, Parietal Lobe, Cortex, Temporal Lobe, Occipital Lobe, Testes, Eye

Publications for Dysgraphia

Articles related to Dysgraphia:

(show top 50) (show all 1116)
# Title Authors PMID Year
1
Proactive interference apraxic agraphia: a writing and drawing disorder associated with corticobasal syndrome. 61
32323627 2020
2
Seeing is not believing. 61
30953621 2020
3
A case of myelin oligodendrocyte glycoprotein-antibody-associated disease presenting with tumefactive demyelinating lesion. 61
32474283 2020
4
Disorder of written expression and dysgraphia: definition, diagnosis, and management. 61
32206583 2020
5
Extending the Spectrum of Dysgraphia: A Data Driven Strategy to Estimate Handwriting Quality. 61
32081940 2020
6
Children 'At Risk' of Developing Specific Learning Disability in Primary Schools. 61
31865523 2020
7
Clinical phenotype heterogeneity in a family with ε-sarcoglycan gene mutation. 61
31956970 2020
8
Ictal multicomponent agraphia in left temporal lobe epilepsy. 61
31889011 2020
9
Agraphia manifesting during a WhatsApp conversation. 61
29169804 2020
10
Alexia Without Agraphia as the Initial Manifestation of Progressive Multifocal Leukoencephalopathy in Chronic Lymphocytic Leukemia. 61
31839871 2020
11
Does surface dyslexia/dysgraphia relate to semantic deficits in the semantic variant of primary progressive aphasia? 61
31682928 2019
12
A case of aneurysmal subarchnoid haemorrhage and superficial siderosis complicated by prospagnosia, simultagnosia and alexia without agraphia. 61
31790281 2019
13
Motor functions of higher education students with dysgraphia. 61
31518720 2019
14
Specific Learning Disabilities: The Family Physician's Role. 61
31730315 2019
15
[Progressive supranuclear palsy-Richardson syndrome with visual attention disturbance (Holmes and Horrax) and ataxie optique (Garcin): a case report]. 61
31656263 2019
16
Maximising recovery from aphasia with central and peripheral agraphia: The benefit of sequential treatments. 61
29298550 2019
17
[A Skilled Typist with Typing Disorder Following Resection of a Left Frontal Lobe Tumor]. 61
31588054 2019
18
History of cerebral localization and the emigration plight of three neuroscience giants from Nazi Germany: Josef Gerstmann, Adolf Wallenberg, and Franz Josef Kallmann. 61
31473673 2019
19
The making of a syndrome: The English translation of Gerstmann's first report. 61
31029874 2019
20
Alexia and Agraphia Intervention Following Traumatic Brain Injury: A Single Case Study. 61
31194917 2019
21
Academic accommodation strategies for pharmacy students with learning disabilities: What else can be done? 61
31227188 2019
22
Too harts, won sole: Using dysgraphia treatment to address homophone representation. 61
31257990 2019
23
Alexia without Agraphia-report of Five Cases and Review of Literature. 61
31559778 2019
24
High Prevalence of Dysgraphia in Elementary Through High School Students With ADHD and Autism. 61
28741400 2019
25
Quantitative assessment of drawing tests in children with dyslexia and dysgraphia. 61
29748041 2019
26
Effect of levodopa on handwriting tasks of different complexity in Parkinson's disease: a kinematic study. 61
30877380 2019
27
An Eye-Tracking Method for Directly Assessing Children's Visual-Motor Integration. 61
30806663 2019
28
Multi-step treatment for acquired alexia and agraphia (part II): a dual-route error scoring system. 61
28421910 2019
29
Multi-step treatment for acquired alexia and agraphia (Part I): efficacy, generalisation, and identification of beneficial treatment steps. 61
28421858 2019
30
Gray Matter Correlates of Finger Gnosis in Children: A VBM Study. 61
30699334 2019
31
Technology-enhanced writing therapy for people with aphasia: results of a quasi-randomized waitlist controlled study. 61
29749112 2019
32
Maurice Ravel's dementia: the silence of a genius. 61
30810599 2019
33
Cognitive Rehabilitation of Acquired Calculation Disturbances. 61
31093301 2019
34
Alexia and Agraphia from 1861 to 1965. 61
31220840 2019
35
Dural arteriovenous fistula associated with intratumor hemorrhage. 61
30391309 2019
36
Epilepsy phenotype in patients with Xp22.31 microduplication. 61
30603611 2019
37
Kanji (Morphogram) and Kana (Phonogram) Problem in Japanese Alexia and Agraphia. 61
31220841 2019
38
Psychometric Properties of Screening Questionnaires for Children With Handwriting Issues. 61
32038361 2019
39
The effects of lesion and treatment-related recovery on functional network modularity in post-stroke dysgraphia. 61
31146116 2019
40
Developmental coordination disorder and dysgraphia: signs and symptoms, diagnosis, and rehabilitation. 61
31371960 2019
41
Clinical Reasoning: A 61-year-old woman with acute onset dysgraphia. 61
30665917 2019
42
Methodological issues in the creation of a diagnosis tool for dysgraphia. 61
31304382 2019
43
Reply: Limitations in the creation of an automatic diagnosis tool for dysgraphia. 61
31304383 2019
44
Behavioral and brain evidence for language by ear, mouth, eye, and hand and motor skills in literacy learning. 61
32123644 2019
45
A phonetic radical account of the phonology-to-Orthography consistency effect on writing Chinese characters: Evidence from a Chinese Dysgraphic patient. 61
30145937 2018
46
Evaluating Spelling in Glioma Patients Undergoing Awake Surgery: a Systematic Review. 61
30578451 2018
47
Letter Specific Dysgraphia: A Silent Stutter. 61
30637286 2018
48
Emotional and Behavioral Correlates of Persisting Specific Learning Disabilities in Written Language during Middle Childhood and Early Adolescence. 61
30555207 2018
49
Developmental dysgraphia is often associated with minor neurological dysfunction in children with developmental coordination disorder (DCD). 61
29605507 2018
50
Here's How I Write-Hebrew: Psychometric Properties and Handwriting Self-Awareness Among Schoolchildren With and Without Dysgraphia. 61
30157018 2018

Variations for Dysgraphia

Expression for Dysgraphia

Search GEO for disease gene expression data for Dysgraphia.

Pathways for Dysgraphia

GO Terms for Dysgraphia

Cellular components related to Dysgraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 main axon GO:0044304 8.62 MAPT C9orf72

Biological processes related to Dysgraphia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stress granule assembly GO:0034063 8.62 MAPT C9orf72

Sources for Dysgraphia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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