MCID: DYS011
MIFTS: 41

Dyskinesia of Esophagus

Categories: Gastrointestinal diseases

Aliases & Classifications for Dyskinesia of Esophagus

MalaCards integrated aliases for Dyskinesia of Esophagus:

Name: Dyskinesia of Esophagus 12 15
Esophageal Motility Disorders 54 44 70
Dyskinesia of Oesophagus 12 32
Esophageal Motility Disorder 12
Oesophageal Motor Disorder 12
Oesophageal Dysmotility 12
Esophageal Dysmotility 12
Esophageal Spasm 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9192
ICD9CM 34 530.5
MeSH 44 D015154
SNOMED-CT 67 40846004
ICD10 32 K22.4
UMLS 70 C0014858 C0014863

Summaries for Dyskinesia of Esophagus

MalaCards based summary : Dyskinesia of Esophagus, also known as esophageal motility disorders, is related to crest syndrome and scleroderma, familial progressive, and has symptoms including spasm An important gene associated with Dyskinesia of Esophagus is CENPB (Centromere Protein B), and among its related pathways/superpathways is Secretion of Hydrochloric Acid in Parietal Cells. The drugs Guaifenesin and Codeine have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and spinal cord.

Related Diseases for Dyskinesia of Esophagus

Diseases related to Dyskinesia of Esophagus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 crest syndrome 31.2 TOP1 SNRNP70 FBL EXOSC10 CENPS CENPC
2 scleroderma, familial progressive 30.8 TOP1 FBL CENPB
3 gastroesophageal reflux 30.4 MLN HRH2 CCL26 ATP4A ATP12A
4 mediastinitis 30.4 ATP4A ATP12A
5 esophageal candidiasis 30.3 CCL26 ATP4A ATP12A
6 esophagitis 30.2 IL13 HRH2 CCL26 CAPN14
7 esophageal varix 30.1 ATP4A ATP12A
8 esophagitis, eosinophilic, 1 30.1 IL13 CCL26 CAPN14 ATP4A ATP12A
9 hernia, hiatus 30.1 MLN HRH2 ATP4A ATP12A
10 peptic esophagitis 30.0 MLN HRH2 CCL26 ATP4A ATP12A
11 esophageal disease 29.9 CCL26 ATP4A ATP12A
12 telangiectasis 29.6 TRIM21 TOP1 SNRNP70 FBL EXOSC10 CENPS
13 connective tissue disease 29.2 TOP1 SSB SNRNP70 FBL CENPC CENPB
14 diffuse scleroderma 29.0 TSSK1B TRIM21 TOP1 SNRNP70 FBL EXOSC10
15 systemic scleroderma 28.2 TSSK1B TRIM21 TOP1 SNRNP70 MLN IL13
16 paroxysmal nocturnal hemoglobinuria 11.1
17 dysphagia 10.6
18 achalasia 10.5
19 duodenitis 10.4 ATP4A ATP12A
20 vagus nerve disease 10.4 ATP4A ATP12A
21 raynaud phenomenon 10.4
22 necrotizing gastritis 10.4 ATP4A ATP12A
23 scalp dermatosis 10.4 ATP4A ATP12A
24 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
25 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
26 lingual goiter 10.4 ATP4A ATP12A
27 displacement of cardia through esophageal hiatus 10.4 ATP4A ATP12A
28 bacterial esophagitis 10.4 ATP4A ATP12A
29 benzylpenicillin allergy 10.4 ATP4A ATP12A
30 median arcuate ligament syndrome 10.4 ATP4A ATP12A
31 afferent loop syndrome 10.4 ATP4A ATP12A
32 cervix erosion 10.4 ATP4A ATP12A
33 angiodysplasia of intestine 10.4 ATP4A ATP12A
34 angiodysplasia 10.4 ATP4A ATP12A
35 granulomatous gastritis 10.4 ATP4A ATP12A
36 laryngeal tuberculosis 10.4 ATP4A ATP12A
37 fungal esophagitis 10.4 ATP4A ATP12A
38 dieulafoy lesion 10.4 ATP4A ATP12A
39 esophagus melanoma 10.4 ATP4A ATP12A
40 emphysematous cholecystitis 10.4 ATP4A ATP12A
41 gastric gastrinoma 10.4 ATP4A ATP12A
42 viral laryngitis 10.4 ATP4A ATP12A
43 gastroduodenal crohn's disease 10.4 ATP4A ATP12A
44 polyposis, skin pigmentation, alopecia, and fingernail changes 10.4 ATP4A ATP12A
45 central nervous system origin vertigo 10.4 ATP4A ATP12A
46 internal hemorrhoid 10.4 ATP4A ATP12A
47 hemorrhoid 10.4 ATP4A ATP12A
48 acute laryngitis 10.4 ATP4A ATP12A
49 chronic intestinal vascular insufficiency 10.4 ATP4A ATP12A
50 barbiturate abuse 10.4 ATP4A ATP12A

Comorbidity relations with Dyskinesia of Esophagus via Phenotypic Disease Network (PDN): (show all 18)


Acute Cystitis Anxiety
Bronchitis Deficiency Anemia
Dysthymic Disorder Esophageal Disease
Esophagitis Gastroesophageal Reflux
Heart Disease Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Irritable Bowel Syndrome Megaesophagus
Mitral Valve Disease Osteoporosis
Protein-Energy Malnutrition Swallowing Disorders

Graphical network of the top 20 diseases related to Dyskinesia of Esophagus:



Diseases related to Dyskinesia of Esophagus

Symptoms & Phenotypes for Dyskinesia of Esophagus

UMLS symptoms related to Dyskinesia of Esophagus:


spasm

Drugs & Therapeutics for Dyskinesia of Esophagus

Drugs for Dyskinesia of Esophagus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
2
Codeine Approved, Illicit Phase 4 76-57-3 5284371
3
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
4
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
5
Edrophonium Approved Phase 4 312-48-1, 116-38-1 3202
6 Narcotics Phase 4
7 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
8 Antitussive Agents Phase 4
9 Analgesics, Opioid Phase 4
10 Adrenocorticotropic Hormone Phase 4
11 Corticotropin-Releasing Hormone Phase 4
12 Respiratory System Agents Phase 4
13 Anti-Arrhythmia Agents Phase 4
14 Anti-Asthmatic Agents Phase 4
15 Antidotes Phase 4
16 Parasympatholytics Phase 4
17 Cholinergic Antagonists Phase 4
18 Cholinesterase Inhibitors Phase 4
19 Anti-Inflammatory Agents Phase 4
20 Protective Agents Phase 4
21 Mydriatics Phase 4
22 Muscarinic Antagonists Phase 4
23 Bronchodilator Agents Phase 4
24
Azithromycin Approved Phase 2 83905-01-5 55185 447043
25
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2 7487-88-9 24083
26 Anti-Bacterial Agents Phase 2
27 Anti-Infective Agents Phase 2
28 Analgesics Phase 2
29 Hormones Phase 2
30 Anticonvulsants Phase 2
31 Tocolytic Agents Phase 2
32 Calcium, Dietary Phase 2
33 calcium channel blockers Phase 2
34
Calcium Nutraceutical Phase 2 7440-70-2 271
35
Bethanechol Approved Phase 1 674-38-4 2370
36 Pharmaceutical Solutions Phase 1
37 Muscarinic Agonists Phase 1
38
Cefazolin Approved 25953-19-9 656510 33255
39
Amoxicillin Approved, Vet_approved 26787-78-0 33613
40 Clavulanic Acids
41 Antibiotics, Antitubercular
42 Hemostatics

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Effect of Codeine on Pharyngeal and Esophageal Motility in Healthy Subjects: a Double-blind, Placebo-controlled, Randomized, Cross-over Study Completed NCT03784105 Phase 4 Codeine Phosphate;Siripus simplex
2 The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy Volunteers Completed NCT02736734 Phase 4 CRH
3 Comprehensive Assessment of Histopathologic and Physiologic Profile in Esophageal Motility Disorders Recruiting NCT04641702 Phase 4 Edrophonium challenge;Atropine challenge
4 Comparison of Solid-State Esophageal Manometry and Water Perfused Anorectal Manometry Catheters With Air Filled Multi-Balloon Esophageal and Anorectal Manometry Catheters Terminated NCT00204763 Phase 4
5 Endoscopic Submucosal Tunnel Dissection for Endolumenal Partial Myotomy of the Lower Esophageal Sphincter for Atypical Primary Motility Disorders Such as Achalasia and Esophageal Spasm Unknown status NCT01302301 Phase 2
6 Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Unknown status NCT01524458 Phase 1, Phase 2
7 Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Unknown status NCT01524471 Phase 2
8 Effect Of Azithromycin On Oesophageal Function In Patients With Dysphagia Or Gastro-Oesophageal Reflux Associated With Frequent Oesophageal Hypomotility Completed NCT01448993 Phase 2 Azithromycin;Placebo
9 Endoscopic Injection of Botulinum Toxin in Patients With Hypercontractile Esophageal Motility Disorders: a Prospective, Randomized, Double-blind, Controlled Study Completed NCT01955174 Phase 2 Esophageal endoscopic injection of botulinum toxin
10 A Prospective, Randomized, Double-blind, Placebo-controlled Trial of the Effects of Magnesium Sulfate on Postoperative Esophageal Spasm-associated Pain Following Peroral Endoscopic Myotomy Recruiting NCT04638881 Phase 2 Magnesium sulfate;Normal Saline
11 Topical Bethanechol for Improvement of Esophageal Dysmotility: A Pilot Study Completed NCT01031043 Phase 1 Bethanechol
12 Observational Field Study of Acute Esophageal Food Bolus Impaction by Mean Esophageal Manometry and 24h-pH-monitoring Unknown status NCT01447823
13 Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery - a Prospective Cohort Study Unknown status NCT03100357
14 Assessment of Esophageal Motility With Transnasal Endoscopy Unknown status NCT01658865
15 Reversibility of Esophageal Dysmotilities Associated With Gastric Banding After Conversion to Gastric Bypass Unknown status NCT00680030
16 Prospective Randomised Double-blind Sham Study on the Use of Botox for the Treatment of Diffuse Esophageal Spasm Unknown status NCT01432782 Placebo;Botulinum Toxin Type A
17 Esophageal Dysmotility Disorders Following Laparoscopic Gastric Banding - An Underestimated Complication. Completed NCT01234428
18 Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease Completed NCT03347903
19 Quality of Life Among Patients With Chronic Esophageal Disorders : Spanish Translation and Validation of the Survey "Northwestern Esophageal Quality of Life Scale" in Hispanics Completed NCT02959424
20 Prospective Study on the Feasibility and Effectiveness of Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders Completed NCT01525732
21 Impact of Antibiotic Prophylaxis and Conditioning Modalities in Per Oral Endoscopic Myotomy for Esophageal Motor Disorders Completed NCT03944863 Antibiotics
22 Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) as Additional Endoscopic Treatment Options for Achalasia and Other Esophageal Motility Disorders Recruiting NCT02518542
23 Different Surgical Procedures of Peroral Endoscopic Myotomy(POEM) for Esophageal Achalasia: a Multicenter Prospective Randomized Controlled Trial Recruiting NCT03012854
24 Impact of Peroral Endoscopic Myotomy and Other Treatments for Oesophageal Motility Disorders on Bolus Transport and Gastro-oesophageal Reflux. The pFlow Study Not yet recruiting NCT03904004
25 Correlation Between Clinical Signs and High-resolution Manometry Data in Children Not yet recruiting NCT03662490
26 Prospective Evaluation of the Use of TIF (Transoral Incisionless Fundoplication) to Treat Post-poem GERD Not yet recruiting NCT04770441
27 Is Visceral Hyperalgesia the Culprit of Noncardiac Chest Pian in Chinese? Part I: The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients Terminated NCT00164814
28 Effectiveness of Semi-rigid Savary Dilators vs. Balloon Dilators During Esophageal Dilation in the Treatment of Esophageal Dysmotility Terminated NCT03604523
29 Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in the Treatment of Medical Refractory Spastic Esophageal Disorders Withdrawn NCT02663206

Search NIH Clinical Center for Dyskinesia of Esophagus

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Isosorbide
Isosorbide Dinitrate
Isosorbide Mononitrate
Nitroglycerin

Cochrane evidence based reviews: esophageal motility disorders

Genetic Tests for Dyskinesia of Esophagus

Anatomical Context for Dyskinesia of Esophagus

MalaCards organs/tissues related to Dyskinesia of Esophagus:

40
Heart, Smooth Muscle, Spinal Cord, Liver, Lung, Thyroid, Skin

Publications for Dyskinesia of Esophagus

Articles related to Dyskinesia of Esophagus:

(show top 50) (show all 665)
# Title Authors PMID Year
1
Achalasia and esophageal cancer: a large database analysis in Japan. 61
33538893 2021
2
Chicago classification version 4.0© technical review: Update on standard high-resolution manometry protocol for the assessment of esophageal motility. 61
33729668 2021
3
Multiple rapid swallows and rapid drink challenge in patients with esophagogastric junction outflow obstruction on high-resolution manometry. 61
33043557 2021
4
Population trends in achalasia diagnosis and management: a changing paradigm. 61
33728431 2021
5
Is it necessary to perform a morphological assessment for an esophageal motility disorder? A retrospective descriptive study. 61
33662774 2021
6
Importance of second-look endoscopy after per-oral endoscopic myotomy for safe postoperative management. 61
32544261 2021
7
Optimal cutoff value of integrated relaxation pressure on the esophagogastric junction to detect outflow obstruction using starlet high-resolution manometry system. 61
33423114 2021
8
Changes in the Treatment of Primary Esophageal Motility Disorders Imposed by the New Classification for Esophageal Motility Disorders on High Resolution Manometry (Chicago Classification 4.0). 61
33772739 2021
9
Rheumatologic disorders in patients undergoing esophageal manometry: prevalence, symptom characteristics, and manometric findings. 61
33558877 2021
10
Development of a preoperative risk-scoring system for predicting poor responders to peroral endoscopic myotomy. 61
32565185 2021
11
[Diagnosis of Dysphagia: High Resolution Manometry & EndoFLIP]. 61
33632996 2021
12
The Modern Age of POEM: the Past, Present and Future of Per-Oral Endoscopic Myotomy. 61
33140317 2021
13
[Endoscopic Management of Dysphagia]. 61
33632998 2021
14
A deep-learning-based unsupervised model on esophageal manometry using variational autoencoder. 61
33581826 2021
15
Normal Functional Luminal Imaging Probe Panometry Findings Associate With Lack of Major Esophageal Motility Disorder on High-Resolution Manometry. 61
32205217 2021
16
Solid Swallow Examination During High Resolution Manometry and EGJ-Distensibility Help Identify Esophageal Outflow Obstruction in Non-obstructive Dysphagia. 61
33609164 2021
17
Utilization of Magnesium in Opioid-Free Anesthesia for Peroral Endoscopic Myotomy: A Case Report. 61
33449540 2021
18
Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0©. 61
33373111 2021
19
Opioid-induce esophageal dysfunction, prevalence and manometric findings. 61
33486967 2021
20
Comparison of the safety and efficacy of peroral endoscopic myotomy between octogenarians and non-octogenarians. 61
32274834 2021
21
A complex modality of achalasia, diverticulum and paraesophageal hernia treated through three-dimensional left thoracoscopy. 61
33353894 2021
22
POEM: clinical outcomes beyond 5 years. 61
33398572 2021
23
Radio-induced esophageal motility disorders: An unrecognized diagnosis. 61
33454192 2021
24
Dysphagia: Evaluation and Collaborative Management. 61
33448766 2021
25
Effects of Pyridostigmine on Esophageal and Pharyngeal Motility in Dysphagic Patients Undergoing High-Resolution Manometry. 61
33452552 2021
26
Inflammatory conditions of the esophagus: an update. 61
32783223 2020
27
Peroral endoscopic myotomy alone is effective for esophageal motility disorders and esophageal epiphrenic diverticulum: a retrospective single-center study. 61
31993815 2020
28
Spectrum of esophageal motility disorders in patients with liver cirrhosis. 61
33442445 2020
29
Silent Gastroesophageal Reflux Disease in Patients with Morbid Obesity Prior to Primary Metabolic Surgery. 61
32910407 2020
30
Prevalence and clinical significance of esophageal motility disorders in patients with laryngopharyngeal reflux symptoms. 61
33373479 2020
31
Jackhammer Esophagus: Current Concepts and Dilemmas. 61
33337637 2020
32
Spectrum and Clinical Outcome of Motility Disorders on High-Resolution Esophageal Manometry: A Study From a Tertiary Center on Patients With Dysphagia in Pakistan. 61
33489506 2020
33
Treatment experience with a novel 30-mm hydrostatic balloon in esophageal dysmotility: a multicenter retrospective analysis. 61
32417296 2020
34
Efficacy of per-oral endoscopic myotomy for the treatment of non-achalasia esophageal motor disorders. 61
31932930 2020
35
How to Cope with Big Data in Functional Analysis of the Esophagus. 61
33447599 2020
36
Can esophageal motility disorders be detected by esophagogastroduodenoscopy? 61
33377566 2020
37
Diagnostic yield of adding solid food swallows during high-resolution manometry in esophageal motility disorders. 61
33314459 2020
38
Effects of Posture and Swallow Volume on Esophageal Motility Morphology and Probability of Bolus Clearance: A Study Using High-Resolution Impedance Manometry. 61
33259432 2020
39
Peroral Endoscopic Myotomy for Esophageal Motility Disorders. 61
33212547 2020
40
Assessment of esophageal motility disorders by real-time MRI. 61
33010683 2020
41
Esophageal motility disorders in children with dysphagia: the utility of the Chicago classification. 61
33054306 2020
42
Esophageal Motility Disorders and Gastroesophageal Reflux Disease. 61
33176086 2020
43
Comparison of Objective Intermediate-Term Outcomes Between per-Oral Endoscopic Myotomy and Laparoscopic Heller Myotomy Show Equivalence. 61
33153391 2020
44
The role of ambulatory 24-hour esophageal manometry in clinical practice. 61
32391594 2020
45
Postobesity Surgery Esophageal Dysfunction: A Combined Cross-Sectional Prevalence Study and Retrospective Analysis. 61
32558689 2020
46
An evaluation of the complication risks following peroral endoscopic myotomy in patients on antithrombotic therapy. 61
33033912 2020
47
Relationship between distension-contraction waveforms during esophageal peristalsis: effect of bolus volume, viscosity, and posture. 61
32755311 2020
48
Computerized Learning Is a Building Block But We Still Have Far to Go. 61
32675589 2020
49
Clinical significance of esophagogastroduodenoscopy in patients with esophageal motility disorders. 61
32892432 2020
50
Esophageal Motility Disorders. 61
32866357 2020

Variations for Dyskinesia of Esophagus

Expression for Dyskinesia of Esophagus

Search GEO for disease gene expression data for Dyskinesia of Esophagus.

Pathways for Dyskinesia of Esophagus

Pathways related to Dyskinesia of Esophagus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.32 HRH2 ATP4A

GO Terms for Dyskinesia of Esophagus

Cellular components related to Dyskinesia of Esophagus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromosome GO:0005694 9.63 TOP1 FBL CENPS CENPC CENPB CENPA
2 kinetochore GO:0000776 9.58 CENPS CENPC CENPA
3 chromosome, centromeric region GO:0000775 9.56 CENPS CENPC CENPB CENPA
4 condensed chromosome kinetochore GO:0000777 9.54 CENPS CENPC CENPA
5 condensed nuclear chromosome kinetochore GO:0000778 9.32 CENPC CENPA
6 condensed chromosome, centromeric region GO:0000779 9.13 CENPC CENPB CENPA
7 pericentric heterochromatin GO:0005721 8.8 CENPC CENPB CENPA

Biological processes related to Dyskinesia of Esophagus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular sodium ion homeostasis GO:0006883 9.37 ATP4A ATP12A
2 sodium ion export across plasma membrane GO:0036376 9.32 ATP4A ATP12A
3 cellular potassium ion homeostasis GO:0030007 9.26 ATP4A ATP12A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP4A ATP12A
5 CENP-A containing nucleosome assembly GO:0034080 9.13 CENPS CENPC CENPA
6 kinetochore assembly GO:0051382 8.8 CENPS CENPC CENPA

Molecular functions related to Dyskinesia of Esophagus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
3 centromeric DNA binding GO:0019237 8.96 CENPC CENPB
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Dyskinesia of Esophagus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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