MCID: DYS001
MIFTS: 36

Dyskinetic Cerebral Palsy

Categories: Neuronal diseases, Rare diseases
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Aliases & Classifications for Dyskinetic Cerebral Palsy

MalaCards integrated aliases for Dyskinetic Cerebral Palsy:

Name: Dyskinetic Cerebral Palsy 11 14 31 33
Athetoid Cerebral Palsy 19 71 33
Athetoid Dyskinetic Cerebral Palsy 11
Dyskinetic Cerebral Paralysis 33
Athetoid Cerebral Paralysis 33
Cerebral Palsy Dyskinetic 19
Double Athetosis Syndrome 33
Cerebral Palsy Athetoid 19
Athetoid Cerebrum Palsy 33
Vogt Disease 33
État Marbré 33

Classifications:



External Ids:

Disease Ontology 11 DOID:0050672
ICD10 31 G80.3
ICD11 33 812740125
UMLS 71 C0270742

Summaries for Dyskinetic Cerebral Palsy

Disease Ontology: 11 A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

MalaCards based summary: Dyskinetic Cerebral Palsy, also known as athetoid cerebral palsy, is related to dystonia and movement disease, and has symptoms including bradykinesia and abnormality of extrapyramidal motor function. An important gene associated with Dyskinetic Cerebral Palsy is MRPS25 (Mitochondrial Ribosomal Protein S25), and among its related pathways/superpathways are Metabolism of proteins and Viral mRNA Translation. Affiliated tissues include globus pallidus, brain and eye, and related phenotypes are no effect and no effect

GARD: 19 A form of dyskinetic cerebral palsy with slow, writhing movements that are often repetitive, sinuous, and rhythmic.

Related Diseases for Dyskinetic Cerebral Palsy

Diseases related to Dyskinetic Cerebral Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 dystonia 30.7 SGCE PCDH12 GCDH ADCY5
2 movement disease 30.4 SGCE GNAO1 GCDH ADCY5
3 choreatic disease 29.8 SGCE GPR88 GNAO1 ADCY5
4 intellectual disability - athetosis - microphthalmia 11.8
5 cerebral palsy 11.6
6 ceroid lipofuscinosis, neuronal, 3 11.5
7 cerebral palsy, ataxic, autosomal recessive 11.2
8 papillon-lefevre syndrome 11.1
9 asphyxia neonatorum 10.5
10 cardiofaciocutaneous syndrome 1 10.4
11 spastic paraplegia 35, autosomal recessive, with or without neurodegeneration 10.4
12 spastic cerebral palsy 10.4
13 hereditary spastic paraplegia 35 10.4
14 bilirubin metabolic disorder 10.4
15 neonatal hypoxic and ischemic brain injury 10.4
16 macs syndrome 10.4
17 spasticity 10.4
18 neuronal ceroid lipofuscinosis 10.4
19 spondylosis 10.4
20 radiculopathy 10.3
21 cervical dystonia 10.3
22 microcephaly 10.3
23 kernicterus 10.3
24 encephalopathy 10.3
25 spondylosis, cervical 10.2
26 spinal stenosis 10.2
27 torticollis 10.2
28 ocular motility disease 10.2
29 epilepsy 10.2
30 learning disability 10.2
31 behcet syndrome 10.1
32 polycystic liver disease 1 with or without kidney cysts 10.1
33 ataxia with vitamin e deficiency 10.1
34 polydactyly 10.1
35 scoliosis 10.1
36 spinal disease 10.1
37 respiratory failure 10.1
38 quadriplegia 10.1
39 hyperuricemia 10.1
40 exostosis 10.1
41 spondylolysis 10.1
42 nutritional deficiency disease 10.1
43 speech disorder 10.1
44 pathologic nystagmus 10.1
45 multiple congenital anomalies/dysmorphic syndrome-intellectual disability 10.1
46 chorea, benign hereditary 10.1
47 huntington disease 10.1
48 optic nerve hypoplasia, bilateral 10.1
49 septooptic dysplasia 10.1
50 corpus callosum, agenesis of 10.1

Graphical network of the top 20 diseases related to Dyskinetic Cerebral Palsy:



Diseases related to Dyskinetic Cerebral Palsy

Symptoms & Phenotypes for Dyskinetic Cerebral Palsy

UMLS symptoms related to Dyskinetic Cerebral Palsy:


bradykinesia; abnormality of extrapyramidal motor function

GenomeRNAi Phenotypes related to Dyskinetic Cerebral Palsy according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.05 ADCY5 ATAD3A ATP8A2 GCDH GNAO1 GPR88
2 no effect GR00402-S-2 10.05 ADCY5 ATP8A2 GCDH GNAO1 MRPL11 MRPL24

Drugs & Therapeutics for Dyskinetic Cerebral Palsy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Placebo-Controlled Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents Completed NCT03813238 Phase 3 Deutetrabenazine;Placebo
2 An Open-Label, Long-Term Safety, Tolerability, and Efficacy Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents (Open RECLAIM-DCP) Recruiting NCT04200352 Phase 3 TEV-50717
3 Efficacy of Axial Stability on Improving Gait and Balance Performance in Children With Dyskinetic Cerebral Palsy Completed NCT03037697
4 Functional Benefits of Multisite Surgery for the Upper Limb of Children With Cerebral Palsy Recruiting NCT04395729
5 Effect of Deep Brain Stimulation in the Globus Pallidus Internus on Quality of Life in Young Patients With Dyston-dyskinetic Cerebral Palsy Active, not recruiting NCT02097693

Search NIH Clinical Center for Dyskinetic Cerebral Palsy

Genetic Tests for Dyskinetic Cerebral Palsy

Anatomical Context for Dyskinetic Cerebral Palsy

Organs/tissues related to Dyskinetic Cerebral Palsy:

MalaCards : Globus Pallidus, Brain, Eye, Spinal Cord, Appendix, Thyroid, Lung

Publications for Dyskinetic Cerebral Palsy

Articles related to Dyskinetic Cerebral Palsy:

(show top 50) (show all 326)
# Title Authors PMID Year
1
Eye movements and stress during eye-tracking gaming performance in children with dyskinetic cerebral palsy. 62
35393636 2022
2
A novel investigation of eye-gaze as an access method for children with dyskinetic cerebral palsy. 62
35598090 2022
3
Combined Anterior-Posterior Fusion Versus Posterior Alone Fusion for Cervical Myelopathy in Athetoid-Cerebral Palsy. 62
33487049 2022
4
Surgical outcomes of cervical myelopathy in patients with athetoid cerebral palsy. 62
34455477 2022
5
Exercise load and physical activity intensity in relation to dystonia and choreoathetosis during powered wheelchair mobility in children and youth with dyskinetic cerebral palsy. 62
33970729 2022
6
Gabapentin as Add-on Therapy to Trihexyphenidyl in Children with Dyskinetic Cerebral Palsy: A Randomized, Controlled Trial. 62
35867274 2022
7
A retrospective cohort study about hip luxation in non-ambulatory cerebral palsy patients: The point of no return. 62
35800654 2022
8
Home-Based Measurements of Dystonia in Cerebral Palsy Using Smartphone-Coupled Inertial Sensor Technology and Machine Learning: A Proof-of-Concept Study. 62
35746168 2022
9
Brivaracetam for dyskinetic cerebral palsy. 62
35653104 2022
10
Accommodations to cognitive assessment for a child with dyskinetic cerebral palsy: case study. 62
35730760 2022
11
Effect of targeted movement interventions on pain and quality of life in children with dyskinetic cerebral palsy: a pilot single subject research design to test feasibility of parent-reported assessments. 62
35544592 2022
12
A Novel Technique for Occipitocervical Fusion with Triple Rod Connection to Prevent Implant Failure. 62
35693373 2022
13
Two Siblings with Cerebellar Ataxia, Mental Retardation, and Disequilibrium Syndrome 4 and a Novel Variant of ATP8A2. 62
35321980 2022
14
Quality of Life After Deep Brain Stimulation of Pediatric Patients with Dyskinetic Cerebral Palsy: A Prospective, Single-Arm, Multicenter Study with a Subsequent Randomized Double-Blind Crossover (STIM-CP). 62
34967053 2022
15
Attainment of personal goals in the first year of intrathecal baclofen treatment in dyskinetic cerebral palsy: a prospective cohort study. 62
35387541 2022
16
Using both electromyography and movement disorder assessment improved the classification of children with dyskinetic cerebral palsy. 62
34655503 2022
17
Psychometric properties of upper limb kinematics during functional tasks in children and adolescents with dyskinetic cerebral palsy. 62
36149848 2022
18
Measuring the impact of dyskinesia on function in children with dyskinetic cerebral palsy. 62
34297844 2021
19
The Dyskinetic Cerebral Palsy Functional Impact Scale: development and validation of a new tool. 62
34145577 2021
20
The immediate effect of different loads does not alter muscle co-activation of the upper limb in young adults with dyskinetic cerebral palsy. 62
34482220 2021
21
Secondary biogenic amine deficiencies: genetic etiology, therapeutic interventions, and clinical effects. 62
34213677 2021
22
Hyperbilirubinemia and Asphyxia in Children With Dyskinetic Cerebral Palsy. 62
34023554 2021
23
Acquired Os Odentoideum Due to Cervical Dystonia in a Child With Dyskinetic Cerebral Palsy. 62
32543019 2021
24
Childhood neurodevelopmental outcomes of survivors of acute bilirubin encephalopathy: A retrospective cohort study. 62
33990043 2021
25
Clinical Profile and Outcome of Indian Children with Aromatic L-Amino Acid Decarboxylase Deficiency: A primary CSF Neurotransmitter Disorder Mimicking as Dyskinetic Cerebral Palsy. 62
33996177 2021
26
Clinical Presentation of Spasticity and Passive Range of Motion Deviations in Dyskinetic Cerebral Palsy in Relation to Dystonia, Choreoathetosis, and Functional Classification Systems. 62
33356718 2021
27
Upper Extremity Strengthening for an Individual With Dyskinetic Cerebral Palsy: A Case Report. 62
33653985 2021
28
Low excretor glutaric aciduria type 1 of insidious onset with dystonia and atypical clinical features, a diagnostic dilemma. 62
33728242 2021
29
Functional outcomes of children with dyskinetic cerebral palsy depend on etiology and gestational age. 62
33246885 2021
30
'Imaging and genetic information link aetiological mechanisms, structural brain injury patterns and functional outcomes in dyskinetic cerebral palsy in Osaka.' 62
33556747 2021
31
Risk factors for hip dislocation in dyskinetic cerebral palsy. 62
33745368 2021
32
A Retrospective Longitudinal Study in a Cohort of Children With Dyskinetic Cerebral Palsy Treated With Tetrabenazine. 62
33716922 2021
33
Can spatial filtering separate voluntary and involuntary components in children with dyskinetic cerebral palsy? 62
33852638 2021
34
Dystonia and choreoathetosis presence and severity in relation to powered wheelchair mobility performance in children and youth with dyskinetic cerebral palsy. 62
32868197 2020
35
Eye Gaze Gaming Intervention in Children with Dyskinetic Cerebral Palsy: A Pilot Study of Task Performance and Its Relation with Dystonia and Choreoathetosis. 62
32496837 2020
36
Chorea in children: etiology, diagnostic approach and management. 62
32776155 2020
37
Dyskinesia Impairment Scale scores in Dutch pre-school children after neonatal therapeutic hypothermia. 62
32950367 2020
38
Deep brain stimulation reduces pain in children with dystonia, including in dyskinetic cerebral palsy. 62
32386250 2020
39
Reliability and Validity of the Dyskinesia Impairment Scale in Children and Young Adults with Inherited or Idiopathic Dystonia. 62
32796550 2020
40
Congenital Malformations in Children With Cerebral Palsy: Is Prematurity Protective? 62
32386793 2020
41
Delayed Diagnoses of SGCE Myoclonus-Dystonia. 62
32775037 2020
42
Movement Disorders - Childhood Rating Scale 4-18 revised in children with dyskinetic cerebral palsy. 62
31976641 2020
43
More Than 10-year Follow-up After Laminoplasty and Pedicle Screw Fixation for Cervical Myelopathy Associated With Athetoid Cerebral Palsy. 62
31977680 2020
44
Presence and severity of dystonia and choreoathetosis overflow movements in participants with dyskinetic cerebral palsy and their relation with functional classification scales. 62
30620229 2020
45
Use of the Dyskinesia Impairment Scale in non-ambulatory dyskinetic cerebral palsy. 62
31784988 2020
46
Test-retest reliability of the Dyskinesia Impairment Scale: measuring dystonia and choreoathetosis in dyskinetic cerebral palsy. 62
31833574 2020
47
A questionnaire survey on the efficacy of various treatments for dyskinetic cerebral palsy due to preterm bilirubin encephalopathy. 62
32063420 2020
48
A motor learning therapeutic intervention for a child with cerebral palsy through a social assistive robot. 62
30806105 2020
49
Instrumented assessment of motor function in dyskinetic cerebral palsy: a systematic review. 62
32138731 2020
50
BCAP31-related syndrome: The first de novo report. 62
31330203 2020

Variations for Dyskinetic Cerebral Palsy

Expression for Dyskinetic Cerebral Palsy

Search GEO for disease gene expression data for Dyskinetic Cerebral Palsy.

Pathways for Dyskinetic Cerebral Palsy

Pathways related to Dyskinetic Cerebral Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 MRPS25 MRPS22 MRPS18C MRPS14 MRPL44 MRPL4
2
Show member pathways
12.93 MRPS25 MRPS22 MRPS18C MRPS14 MRPL44 MRPL4
3
Show member pathways
11.77 MRPS25 MRPS22 MRPS18C MRPS14 MRPL44 MRPL4

GO Terms for Dyskinetic Cerebral Palsy

Cellular components related to Dyskinetic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 10.35 MRPS25 MRPS22 MRPS18C MRPS14 MRPL44 MRPL4
2 mitochondrial large ribosomal subunit GO:0005762 9.92 MRPL44 MRPL4 MRPL24 MRPL11
3 mitochondrial inner membrane GO:0005743 9.91 MRPS25 MRPS22 MRPS18C MRPS14 MRPL44 MRPL4
4 mitochondrial ribosome GO:0005761 9.88 MRPS22 MRPS14 MRPL11
5 mitochondrial small ribosomal subunit GO:0005763 9.86 MRPS14 MRPS18C MRPS22 MRPS25
6 ribosome GO:0005840 9.76 MRPS25 MRPS22 MRPS18C MRPS14 MRPL44 MRPL4
7 ribonucleoprotein complex GO:1990904 9.23 MRPS25 MRPS22 MRPS18C MRPS14 MRPL44 MRPL4

Biological processes related to Dyskinetic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 translation GO:0006412 9.61 MRPS18C MRPS14 MRPL4 MRPL24 MRPL11
2 mitochondrial translation GO:0032543 9.53 MRPS25 MRPS22 MRPS18C MRPS14 MRPL44 MRPL4

Molecular functions related to Dyskinetic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of ribosome GO:0003735 9.53 MRPS25 MRPS22 MRPS18C MRPS14 MRPL44 MRPL4

Sources for Dyskinetic Cerebral Palsy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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