MCID: DYS001
MIFTS: 31

Dyskinetic Cerebral Palsy

Categories: Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Dyskinetic Cerebral Palsy

MalaCards integrated aliases for Dyskinetic Cerebral Palsy:

Name: Dyskinetic Cerebral Palsy 12 15 32
Athetoid Cerebral Palsy 20 71
Athetoid Dyskinetic Cerebral Palsy 12
Cerebral Palsy Dyskinetic 20
Cerebral Palsy Athetoid 20

Classifications:



External Ids:

Disease Ontology 12 DOID:0050672
ICD10 32 G80.3
UMLS 71 C0270742

Summaries for Dyskinetic Cerebral Palsy

Disease Ontology : 12 A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

MalaCards based summary : Dyskinetic Cerebral Palsy, also known as athetoid cerebral palsy, is related to dystonia and movement disease, and has symptoms including abnormality of extrapyramidal motor function and bradykinesia. An important gene associated with Dyskinetic Cerebral Palsy is PCDH12 (Protocadherin 12), and among its related pathways/superpathways is LPA receptor mediated events. Affiliated tissues include brain, globus pallidus and eye.

Wikipedia : 74 Dyskinetic cerebral palsy (DCP) is a subtype of cerebral palsy (CP) and is characterized by impaired... more...

Related Diseases for Dyskinetic Cerebral Palsy

Diseases related to Dyskinetic Cerebral Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 dystonia 30.5 SGCE PCDH12 NKX2-1 ADCY5
2 movement disease 30.4 SGCE NKX2-1 GNAO1
3 chorea, benign hereditary 30.0 NKX2-1 ADCY5
4 choreatic disease 28.7 SGCE NKX2-1 GPR88 GNAO1 ATP8A2 ADCY5
5 intellectual disability - athetosis - microphthalmia 11.7
6 cerebral palsy 11.5
7 cerebral palsy, ataxic, autosomal recessive 11.2
8 spastic cerebral palsy 10.4
9 spondylosis 10.4
10 spasticity 10.4
11 radiculopathy 10.3
12 cervical dystonia 10.3
13 microcephaly 10.3
14 asphyxia neonatorum 10.3
15 epilepsy 10.3
16 kernicterus 10.3
17 bilirubin metabolic disorder 10.3
18 encephalopathy 10.3
19 spondylosis, cervical 10.2
20 torticollis 10.2
21 chorea, childhood-onset, with psychomotor retardation 10.2
22 learning disability 10.2
23 dysphagia 10.2
24 polydactyly 10.1
25 scoliosis 10.1
26 spinal disease 10.1
27 respiratory failure 10.1
28 quadriplegia 10.1
29 hyperuricemia 10.1
30 spondylolysis 10.1
31 spinal stenosis 10.1
32 speech disorder 10.1
33 pathologic nystagmus 10.1
34 hypotonia 10.1
35 multiple congenital anomalies/dysmorphic syndrome-intellectual disability 10.1
36 optic nerve hypoplasia, bilateral 10.0
37 septooptic dysplasia 10.0
38 schizencephaly 10.0
39 branchiootic syndrome 1 10.0
40 alacrima, achalasia, and mental retardation syndrome 10.0
41 pontocerebellar hypoplasia, type 2e 10.0
42 pontocerebellar hypoplasia 10.0
43 bone resorption disease 10.0
44 blood group incompatibility 10.0
45 placental abruption 10.0
46 nkx2-1-related disorders 10.0
47 absence of septum pellucidum 10.0
48 athetosis 10.0
49 anoxia 10.0
50 brain injury 10.0

Graphical network of the top 20 diseases related to Dyskinetic Cerebral Palsy:



Diseases related to Dyskinetic Cerebral Palsy

Symptoms & Phenotypes for Dyskinetic Cerebral Palsy

UMLS symptoms related to Dyskinetic Cerebral Palsy:


abnormality of extrapyramidal motor function, bradykinesia

Drugs & Therapeutics for Dyskinetic Cerebral Palsy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Placebo-Controlled Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents Recruiting NCT03813238 Phase 3 Deutetrabenazine;Placebo
2 An Open-Label, Long-Term Safety, Tolerability, and Efficacy Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents (Open RECLAIM-DCP) Recruiting NCT04200352 Phase 3 TEV-50717
3 Effect of Deep Brain Stimulation in the Globus Pallidus Internus on Quality of Life in Young Patients With Dyston-dyskinetic Cerebral Palsy Unknown status NCT02097693
4 Efficacy of Axial Stability on Improving Gait and Balance Performance in Children With Dyskinetic Cerebral Palsy Recruiting NCT03037697

Search NIH Clinical Center for Dyskinetic Cerebral Palsy

Genetic Tests for Dyskinetic Cerebral Palsy

Anatomical Context for Dyskinetic Cerebral Palsy

MalaCards organs/tissues related to Dyskinetic Cerebral Palsy:

40
Brain, Globus Pallidus, Eye, Spinal Cord, Thyroid

Publications for Dyskinetic Cerebral Palsy

Articles related to Dyskinetic Cerebral Palsy:

(show top 50) (show all 260)
# Title Authors PMID Year
1
'Imaging and genetic information link aetiological mechanisms, structural brain injury patterns and functional outcomes in dyskinetic cerebral palsy in Osaka.' 61
33556747 2021
2
Combined Anterior-Posterior Fusion Versus Posterior Alone Fusion for Cervical Myelopathy in Athetoid-Cerebral Palsy. 61
33487049 2021
3
Clinical Presentation of Spasticity and Passive Range of Motion Deviations in Dyskinetic Cerebral Palsy in Relation to Dystonia, Choreoathetosis, and Functional Classification Systems. 61
33356718 2020
4
Eye Gaze Gaming Intervention in Children with Dyskinetic Cerebral Palsy: A Pilot Study of Task Performance and Its Relation with Dystonia and Choreoathetosis. 61
32496837 2020
5
Functional outcomes of children with dyskinetic cerebral palsy depend on etiology and gestational age. 61
33246885 2020
6
Dystonia and choreoathetosis presence and severity in relation to powered wheelchair mobility performance in children and youth with dyskinetic cerebral palsy. 61
32868197 2020
7
Chorea in children: etiology, diagnostic approach and management. 61
32776155 2020
8
Dyskinesia Impairment Scale scores in Dutch pre-school children after neonatal therapeutic hypothermia. 61
32950367 2020
9
Reliability and Validity of the Dyskinesia Impairment Scale in Children and Young Adults with Inherited or Idiopathic Dystonia. 61
32796550 2020
10
Deep brain stimulation reduces pain in children with dystonia, including in dyskinetic cerebral palsy. 61
32386250 2020
11
Delayed Diagnoses of SGCE Myoclonus-Dystonia. 61
32775037 2020
12
Congenital Malformations in Children With Cerebral Palsy: Is Prematurity Protective? 61
32386793 2020
13
Presence and severity of dystonia and choreoathetosis overflow movements in participants with dyskinetic cerebral palsy and their relation with functional classification scales. 61
30620229 2020
14
Movement Disorders - Childhood Rating Scale 4-18 revised in children with dyskinetic cerebral palsy. 61
31976641 2020
15
Acquired Os Odentoideum Due to Cervical Dystonia in a Child With Dyskinetic Cerebral Palsy. 61
32543019 2020
16
More Than 10-year Follow-up After Laminoplasty and Pedicle Screw Fixation for Cervical Myelopathy Associated With Athetoid Cerebral Palsy. 61
31977680 2020
17
A motor learning therapeutic intervention for a child with cerebral palsy through a social assistive robot. 61
30806105 2020
18
Test-retest reliability of the Dyskinesia Impairment Scale: measuring dystonia and choreoathetosis in dyskinetic cerebral palsy. 61
31833574 2020
19
Use of the Dyskinesia Impairment Scale in non-ambulatory dyskinetic cerebral palsy. 61
31784988 2020
20
A questionnaire survey on the efficacy of various treatments for dyskinetic cerebral palsy due to preterm bilirubin encephalopathy. 61
32063420 2020
21
Instrumented assessment of motor function in dyskinetic cerebral palsy: a systematic review. 61
32138731 2020
22
BCAP31-related syndrome: The first de novo report. 61
31330203 2020
23
Diagnosis of Bilirubin Encephalopathy in Preterm Infants with Dyskinetic Cerebral Palsy. 61
31587006 2020
24
Cognitive Strategy Training in Childhood-Onset Movement Disorders: Replication Across Therapists. 61
33553070 2020
25
Development of a Data Logger for Capturing Human-Machine Interaction in Wheelchair Head-Foot Steering Sensor System in Dyskinetic Cerebral Palsy. 61
31817941 2019
26
GNAO1 mutation presenting as dyskinetic cerebral palsy. 61
31190250 2019
27
Children with dyskinetic cerebral palsy are severely affected as compared to bilateral spastic cerebral palsy. 61
30933377 2019
28
MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy. 61
31039582 2019
29
Executive function and general intellectual functioning in dyskinetic cerebral palsy: Comparison with spastic cerebral palsy and typically developing controls. 61
31202597 2019
30
There is more to individuals with dyskinetic cerebral palsy than meets the eye. 61
31324274 2019
31
The Effect of Intrathecal Baclofen in Dyskinetic Cerebral Palsy: The IDYS Trial. 61
31050023 2019
32
Adult dyskinetic cerebral palsy: Upper limb movement and muscle function. 61
30810219 2019
33
[Neurosurgical treatment of dystonia]. 61
31124449 2019
34
Effect of Positioning on Tonic Labyrinthine Reflex in Cerebral Palsy: A Single-centre Study from Lahore. 61
31000848 2019
35
Cognitive approach to rehabilitation in children with hyperkinetic movement disorders post-DBS. 61
30796136 2019
36
Oropharyngeal Dysphagia in Adults With Dyskinetic Cerebral Palsy and Cervical Dystonia: A Preliminary Study. 61
29958905 2019
37
Eyes on communication: trialling eye-gaze control technology in young children with dyskinetic cerebral palsy. 61
30252561 2019
38
Aberrant Interhemispheric Functional Organization in Children with Dyskinetic Cerebral Palsy. 61
31011574 2019
39
Status dystonicus: a diagnosis delayed. 61
30209149 2018
40
A commentary on a case of new PCDH12 gene variants presented as dyskinetic cerebral palsy with epilepsy. 61
29904113 2018
41
Safety and immediate effect of gait training using a Hybrid Assistive Limb in patients with cerebral palsy. 61
30154591 2018
42
A Model to Estimate the Optimal Layout for Assistive Communication Touchscreen Devices in Children With Dyskinetic Cerebral Palsy. 61
29985146 2018
43
Posture-Dependent Dysphagia After Botulinum Toxin Type A Injection at Sternocleidomastoid in a Patient With Athetoid Cerebral Palsy. 61
28604409 2018
44
A case of new PCDH12 gene variants presented as dyskinetic cerebral palsy with epilepsy. 61
29556033 2018
45
Anti-N-methyl-d-aspartate receptor encephalitis in children: Incidence and experience in Hong Kong. 61
29599011 2018
46
Protocol for N-of-1 trials proof of concept for rehabilitation of childhood-onset dystonia: Study 1: Protocole des essais de validation à effectif unique pour la réadaptation de la dystonie débutant dans l'enfance : Étude 1. 61
29972044 2018
47
Protocol for N-of-1 trials with replications across therapists for childhood-onset dystonia rehabilitation: Study 2: Protocole des essais à effectif unique avec répétitions par différents ergothérapeutes pour la réadaptation de la dystonie débutant dans l'enfance : Étude 2. 61
29972046 2018
48
Clinical characteristics and functional status of children with different subtypes of dyskinetic cerebral palsy. 61
29794768 2018
49
Botulinum Toxin Type A Injection for Cervical Dystonia in Adults with Dyskinetic Cerebral Palsy. 61
29772695 2018
50
Comparison of Morphological Characteristics of the Subaxial Cervical Spine between Athetoid Cerebral Palsy and Normal Control. 61
29526068 2018

Variations for Dyskinetic Cerebral Palsy

Expression for Dyskinetic Cerebral Palsy

Search GEO for disease gene expression data for Dyskinetic Cerebral Palsy.

Pathways for Dyskinetic Cerebral Palsy

Pathways related to Dyskinetic Cerebral Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 GNAO1 ADCY5

GO Terms for Dyskinetic Cerebral Palsy

Biological processes related to Dyskinetic Cerebral Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 forebrain development GO:0030900 9.16 NKX2-1 GNAO1
2 neuromuscular process controlling balance GO:0050885 8.96 GPR88 ADCY5
3 locomotory behavior GO:0007626 8.92 NKX2-1 GPR88 GNAO1 ADCY5

Sources for Dyskinetic Cerebral Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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