DYX1
MCID: DYS121
MIFTS: 20

Dyslexia 1 (DYX1)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Dyslexia 1

MalaCards integrated aliases for Dyslexia 1:

Name: Dyslexia 1 58 76 30 6
Dyslexia, Susceptibility to, 1 58 13
Dyx1 58 76
Specific Reading Disability Type 1 76
Reading Disability, Specific, 1 58
Word-Blindness, Congenital 58
Congenital Word-Blindness 76
Dyslexia, Type 1 41
Dyslexia 4 76
Dyslexia 7 76
Dyx4 76
Dyx7 76

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
dyslexia 1:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 127700

Summaries for Dyslexia 1

OMIM : 58 Dyslexia is a disorder manifested by difficulty learning to read despite conventional instruction, adequate intelligence, and sociocultural opportunity. It is among the most common neurodevelopmental disorders, with a prevalence of 5 to 12%. Although there is evidence for familial clustering and heritability, the disorder is considered a complex multifactorial trait (Schumacher et al., 2007). (127700)

MalaCards based summary : Dyslexia 1, also known as dyslexia, susceptibility to, 1, is related to dyslexia and perrault syndrome 1. An important gene associated with Dyslexia 1 is DNAAF4 (Dynein Axonemal Assembly Factor 4). Related phenotypes are neurological speech impairment and dyslexia

UniProtKB/Swiss-Prot : 76 Dyslexia 1: A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability.

Related Diseases for Dyslexia 1

Diseases in the Dyslexia family:

Dyslexia 1 Dyslexia 9
Dyslexia 2 Dyslexia 3
Dyslexia 6 Dyslexia 5
Dyslexia 8

Diseases related to Dyslexia 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dyslexia 29.1 DNAAF4-CCPG1 DNAAF4
2 perrault syndrome 1 11.1
3 aphasia 9.9
4 alexia 9.9

Symptoms & Phenotypes for Dyslexia 1

Human phenotypes related to Dyslexia 1:

33
# Description HPO Frequency HPO Source Accession
1 neurological speech impairment 33 HP:0002167
2 dyslexia 33 HP:0010522

Symptoms via clinical synopsis from OMIM:

58
Neuro:
dyslexia
speech defects

Clinical features from OMIM:

127700

Drugs & Therapeutics for Dyslexia 1

Search Clinical Trials , NIH Clinical Center for Dyslexia 1

Genetic Tests for Dyslexia 1

Genetic tests related to Dyslexia 1:

# Genetic test Affiliating Genes
1 Dyslexia 1 30 DNAAF4

Anatomical Context for Dyslexia 1

Publications for Dyslexia 1

Articles related to Dyslexia 1:

# Title Authors Year
1
The effect of contrast on reading speed in dyslexia(1) ( 11024448 )
2000

Variations for Dyslexia 1

ClinVar genetic disease variations for Dyslexia 1:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DNAAF4 NM_130810.3(DNAAF4): c.-3G> A single nucleotide variant Benign rs3743205 GRCh37 Chromosome 15, 55790530: 55790530
2 DNAAF4 NM_130810.3(DNAAF4): c.-3G> A single nucleotide variant Benign rs3743205 GRCh38 Chromosome 15, 55498332: 55498332
3 DNAAF4 NM_130810.3(DNAAF4): c.1249G> T (p.Glu417Ter) single nucleotide variant Benign rs57809907 GRCh37 Chromosome 15, 55722882: 55722882
4 DNAAF4 NM_130810.3(DNAAF4): c.1249G> T (p.Glu417Ter) single nucleotide variant Benign rs57809907 GRCh38 Chromosome 15, 55430684: 55430684

Expression for Dyslexia 1

Search GEO for disease gene expression data for Dyslexia 1.

Pathways for Dyslexia 1

GO Terms for Dyslexia 1

Sources for Dyslexia 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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