DYX2
MCID: DYS120
MIFTS: 23

Dyslexia 2 (DYX2)

Categories: Genetic diseases, Mental diseases

Aliases & Classifications for Dyslexia 2

MalaCards integrated aliases for Dyslexia 2:

Name: Dyslexia 2 58 76 30
Dyslexia, Susceptibility to, 2 58 13
Dyx2 58 76
Specific Reading Disability Type 2 76
Reading Disability, Specific, 2 58
Dyslexia, Type 2 41

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant quantitative trait locus (qtl) 6p21.3


HPO:

33
dyslexia 2:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 600202
MedGen 43 C1838436

Summaries for Dyslexia 2

UniProtKB/Swiss-Prot : 76 Dyslexia 2: A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability.

MalaCards based summary : Dyslexia 2, also known as dyslexia, susceptibility to, 2, is related to dyslexia and dyslexia 1. An important gene associated with Dyslexia 2 is DYX2 (Dyslexia Susceptibility 2). Affiliated tissues include brain, and related phenotype is dyslexia.

Description from OMIM: 600202

Related Diseases for Dyslexia 2

Diseases in the Dyslexia family:

Dyslexia 1 Dyslexia 9
Dyslexia 2 Dyslexia 3
Dyslexia 6 Dyslexia 5
Dyslexia 8

Diseases related to Dyslexia 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dyslexia 31.6 DCDC2 DYX2 KIAA0319
2 dyslexia 1 10.1
3 reading disorder 9.6 DCDC2 KIAA0319
4 specific developmental disorder 9.6 DCDC2 KIAA0319
5 attention deficit-hyperactivity disorder 9.4 DCDC2 KIAA0319

Graphical network of the top 20 diseases related to Dyslexia 2:



Diseases related to Dyslexia 2

Symptoms & Phenotypes for Dyslexia 2

Human phenotypes related to Dyslexia 2:

33
# Description HPO Frequency HPO Source Accession
1 dyslexia 33 HP:0010522

Symptoms via clinical synopsis from OMIM:

58
Neuro:
dyslexia
reading disability

Clinical features from OMIM:

600202

Drugs & Therapeutics for Dyslexia 2

Search Clinical Trials , NIH Clinical Center for Dyslexia 2

Genetic Tests for Dyslexia 2

Genetic tests related to Dyslexia 2:

# Genetic test Affiliating Genes
1 Dyslexia 2 30

Anatomical Context for Dyslexia 2

MalaCards organs/tissues related to Dyslexia 2:

42
Brain

Publications for Dyslexia 2

Articles related to Dyslexia 2:

# Title Authors Year
1
Enrichment of putatively damaging rare variants in the DYX2 locus and the reading-related genes CCDC136 and FLNC. ( 28866788 )
2017
2
The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains. ( 25778907 )
2015
3
Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ. ( 24509779 )
2014
4
Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. ( 22750057 )
2012
5
Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia. ( 17450541 )
2007

Variations for Dyslexia 2

Expression for Dyslexia 2

Search GEO for disease gene expression data for Dyslexia 2.

Pathways for Dyslexia 2

GO Terms for Dyslexia 2

Biological processes related to Dyslexia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 8.96 DCDC2 KIAA0319
2 neuron migration GO:0001764 8.62 DCDC2 KIAA0319

Sources for Dyslexia 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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