DYX2
MCID: DYS120
MIFTS: 23

Dyslexia 2 (DYX2)

Categories: Genetic diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Dyslexia 2

MalaCards integrated aliases for Dyslexia 2:

Name: Dyslexia 2 57 74 29
Dyslexia, Susceptibility to, 2 57 13
Dyx2 57 74
Specific Reading Disability Type 2 74
Reading Disability, Specific, 2 57
Dyslexia, Type 2 40

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant quantitative trait locus (qtl) 6p21.3


HPO:

32
dyslexia 2:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 600202
MedGen 42 C1838436

Summaries for Dyslexia 2

UniProtKB/Swiss-Prot : 74 Dyslexia 2: A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability.

MalaCards based summary : Dyslexia 2, also known as dyslexia, susceptibility to, 2, is related to dyslexia and dyslexia 1. An important gene associated with Dyslexia 2 is DYX2 (Dyslexia Susceptibility 2). Affiliated tissues include brain, and related phenotype is dyslexia.

More information from OMIM: 600202

Related Diseases for Dyslexia 2

Diseases in the Dyslexia family:

Dyslexia 1 Dyslexia 9
Dyslexia 2 Dyslexia 3
Dyslexia 6 Dyslexia 5
Dyslexia 8

Diseases related to Dyslexia 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 dyslexia 31.2 KIAA0319 DYX2 DCDC2
2 dyslexia 1 10.2
3 learning disability 10.2
4 reading disorder 9.4 KIAA0319 DCDC2
5 specific developmental disorder 9.3 KIAA0319 DCDC2
6 attention deficit-hyperactivity disorder 9.1 KIAA0319 DCDC2

Graphical network of the top 20 diseases related to Dyslexia 2:



Diseases related to Dyslexia 2

Symptoms & Phenotypes for Dyslexia 2

Human phenotypes related to Dyslexia 2:

32
# Description HPO Frequency HPO Source Accession
1 dyslexia 32 HP:0010522

Symptoms via clinical synopsis from OMIM:

57
Neuro:
dyslexia
reading disability

Clinical features from OMIM:

600202

Drugs & Therapeutics for Dyslexia 2

Search Clinical Trials , NIH Clinical Center for Dyslexia 2

Genetic Tests for Dyslexia 2

Genetic tests related to Dyslexia 2:

# Genetic test Affiliating Genes
1 Dyslexia 2 29

Anatomical Context for Dyslexia 2

MalaCards organs/tissues related to Dyslexia 2:

41
Brain

Publications for Dyslexia 2

Articles related to Dyslexia 2:

(show all 48)
# Title Authors PMID Year
1
A dyslexia-associated variant in DCDC2 changes gene expression. 38 8
21042874 2011
2
DCDC2 is associated with reading disability and modulates neuronal development in the brain. 38 8
16278297 2005
3
Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language impairment. 8
23746548 2013
4
Cohort Profile: the 'children of the 90s'--the index offspring of the Avon Longitudinal Study of Parents and Children. 8
22507743 2013
5
Genetic variation in the KIAA0319 5' region as a possible contributor to dyslexia. 8
21207242 2011
6
Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia. 8
21046216 2011
7
Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample. 8
20068590 2010
8
A common variant associated with dyslexia reduces expression of the KIAA0319 gene. 8
19325871 2009
9
Association of the KIAA0319 dyslexia susceptibility gene with reading skills in the general population. 8
18829873 2008
10
Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. 8
16385449 2006
11
Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. 8
15717286 2005
12
A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States. 8
15514892 2004
13
Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses. 8
15138886 2004
14
Use of multivariate linkage analysis for dissection of a complex cognitive trait. 8
12587094 2003
15
A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression. 8
12384775 2002
16
Evidence for linkage and association with reading disability on 6p21.3-22. 8
11951179 2002
17
Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder. 8
11920845 2002
18
Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia. 8
11743577 2002
19
A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia. 8
9915953 1999
20
Quantitative-trait locus for specific language and reading deficits on chromosome 6p. 8
9915954 1999
21
Absence of linkage of phonological coding dyslexia to chromosome 6p23-p21.3 in a large family data set. 8
9792873 1998
22
Evidence for linkage of spelling disability to chromosome 15. 8
9634517 1998
23
Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. 8
8981944 1997
24
Quantitative trait locus for reading disability on chromosome 6. 8
7939663 1994
25
Empirical Insights of Individual Website Adjustments for People with Dyslexia. 38
31091827 2019
26
Morpheme-based Reading and Spelling in Italian Children with Developmental Dyslexia and Dysorthography. 38
28177182 2017
27
Enrichment of putatively damaging rare variants in the DYX2 locus and the reading-related genes CCDC136 and FLNC. 38
28866788 2017
28
Opposite Associations between Individual KIAA0319 Polymorphisms and Developmental Dyslexia Risk across Populations: A Stratified Meta-Analysis by the Study Population. 38
27464509 2016
29
Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children. 38
25953057 2016
30
The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains. 38
25778907 2015
31
Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders. 38
25448322 2015
32
Association study of developmental dyslexia candidate genes DCDC2 and KIAA0319 in Chinese population. 38
25230923 2014
33
Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ. 38
24509779 2014
34
Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population. 38
23677054 2013
35
Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. 38
22750057 2012
36
The joint effects of risk status, gender, early literacy and cognitive skills on the presence of dyslexia among a group of high-risk Chinese children. 38
22271420 2012
37
Relative burden of large CNVs on a range of neurodevelopmental phenotypes. 38
22102821 2011
38
Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21. 38
21184582 2011
39
The genetics of reading disability. 38
19302769 2009
40
Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample. 38
18810304 2008
41
The KIAA0319-like (KIAA0319L) gene on chromosome 1p34 as a candidate for reading disabilities. 38
19085271 2008
42
Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia. 38
17450541 2007
43
Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. 38
17033633 2006
44
Process dissociation of sight vocabulary and phonetic decoding in reading: a new perspective on surface and phonological dyslexias. 38
15629491 2005
45
[Clinical application of functional magnetic resonance imaging]. 38
11905006 2002
46
A new gene (DYX3) for dyslexia is located on chromosome 2. 38
10507721 1999
47
Possible relevance of phospholipid abnormalities and genetic interactions in psychiatric disorders: the relationship between dyslexia and schizophrenia. 38
8771057 1995
48
A review of learning disability problems. 38
6765834 1981

Variations for Dyslexia 2

Expression for Dyslexia 2

Search GEO for disease gene expression data for Dyslexia 2.

Pathways for Dyslexia 2

GO Terms for Dyslexia 2

Biological processes related to Dyslexia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 8.96 KIAA0319 DCDC2
2 neuron migration GO:0001764 8.62 KIAA0319 DCDC2

Sources for Dyslexia 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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