Categories: Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Dysphagia

MalaCards integrated aliases for Dysphagia:

Name: Dysphagia 53 29 54 6 32
Deglutition Disorders 70


External Ids:

ICD10 32 R13
UMLS 70 C0011168

Summaries for Dysphagia

NINDS : 53 Having trouble swallowing (dysphagia) is a symptom that accompanies a number of neurological disorders. The problem can occur at any stage of the normal swallowing process as food and liquid move from the mouth, down the back of the throat, through the esophagus and into the stomach. Difficulties can range from a total inability to swallow, to coughing or choking because the food or liquid is entering the windpipe, which is referred to as aspiration. When aspiration is frequent a person can be at risk of developing pneumonia. Food may get "stuck" in the throat or individuals may drool because they cannot swallow their saliva. Neurological conditions that can cause swallowing difficulties are: stroke (the most common cause of dysphagia); traumatic brain injury; cerebral palsy; Parkinson disease and other degenerative neurological disorders such as amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), multiple sclerosis, progressive supranuclear palsy, Huntington disease, and myasthenia gravis. Muscular dystrophy and myotonic dystrophy are accompanied by dysphagia, which is also the cardinal symptom of oculopharyngeal muscular dystrophy, a rare, progressive genetic disorder.

MalaCards based summary : Dysphagia, also known as deglutition disorders, is related to mitochondrial dna depletion syndrome 4b and chronic progressive external ophthalmoplegia, and has symptoms including seizures, nausea and vomiting and constipation. An important gene associated with Dysphagia is ARID1B (AT-Rich Interaction Domain 1B), and among its related pathways/superpathways are Biosynthesis of cofactors and Porphyrin and chlorophyll metabolism. The drugs Fentanyl and Propofol have been mentioned in the context of this disorder. Affiliated tissues include tongue, colon and cortex, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 73 Dysphagia is difficulty in swallowing. Although classified under "symptoms and signs" in ICD-10, in some... more...

Related Diseases for Dysphagia

Diseases related to Dysphagia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1040)
# Related Disease Score Top Affiliating Genes
1 mitochondrial dna depletion syndrome 4b 31.5 TWNK POLG
2 chronic progressive external ophthalmoplegia 31.2 TWNK POLG PIK3C2A COX10
3 leigh syndrome 31.2 TWNK POLG COX15 COX10
4 ptosis 30.4 TWNK POLG PABPN1
5 kearns-sayre syndrome 30.2 TWNK POLG COX10
6 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1 30.1 TWNK POLG
7 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 4 30.0 TWNK POLG
8 neuromuscular disease 29.8 PABPN1 NEB EPRS1 DES
9 autosomal dominant progressive external ophthalmoplegia 29.7 TWNK POLG
10 speech disorder 29.6 PIK3C2A DES ARID1B
11 neuroleptic malignant syndrome 29.5 PIK3C2A DES
12 muscular dystrophy 29.4 RIF1 PIK3C2A PABPN1 NEB DES
13 early myoclonic encephalopathy 29.4 TWNK POLG EPRS1
14 sensory ataxic neuropathy, dysarthria, and ophthalmoparesis 29.2 TWNK POLG
15 batten-turner congenital myopathy 28.9 NEB DES
16 mitochondrial myopathy 28.8 TWNK POLG EPRS1 COX15 COX10
17 myopathy 28.2 TWNK RIF1 POLG PIK3C2A PABPN1 NEB
18 myopathy, areflexia, respiratory distress, and dysphagia, early-onset 11.7
19 plummer vinson syndrome 11.5
20 odontoma-dysphagia syndrome 11.5
21 dysphagia lusoria 11.4
22 opitz-gbbb syndrome 11.3
23 oculopharyngeal muscular dystrophy 11.2
24 swallowing disorders 11.2
25 aspiration pneumonia 11.1
26 opitz gbbb syndrome, type ii 11.1
27 thiamine metabolism dysfunction syndrome 2 11.0
28 amyotrophic lateral sclerosis 1 11.0
29 myasthenia gravis 11.0
30 inclusion body myositis 11.0
31 diffuse idiopathic skeletal hyperostosis 11.0
32 striatonigral degeneration, infantile 11.0
33 central pontine myelinolysis 11.0
34 distal myopathy with vocal cord weakness 11.0
35 supranuclear palsy, progressive, 1 10.9
36 esophagitis, eosinophilic, 1 10.9
37 jackhammer esophagus 10.9
38 basal ganglia calcification, idiopathic, 1 10.9
39 cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss 10.9
40 spinocerebellar ataxia 13 10.9
41 neurodegeneration with brain iron accumulation 3 10.9
42 chromosome 1p36 deletion syndrome 10.9
43 leukodystrophy, hypomyelinating, 15 10.9
44 biotin-thiamine-responsive basal ganglia disease 10.9
45 dyt-thap1 10.9
46 aberrant subclavian artery 10.9
47 systemic scleroderma 10.9
48 pseudobulbar palsy 10.8
49 esophageal tuberculosis 10.8
50 niemann-pick disease, type c1 10.8

Graphical network of the top 20 diseases related to Dysphagia:

Diseases related to Dysphagia

Symptoms & Phenotypes for Dysphagia

UMLS symptoms related to Dysphagia:

seizures; nausea and vomiting; constipation; vomiting; abdominal pain; headache; diarrhea; pseudobulbar signs; nausea; dyspepsia; odynophagia; icterus; signs and symptoms, digestive; heartburn; gastrointestinal gas; digestive system symptom; flatulence, eructation, and gas pain; symptoms involving digestive system; other symptoms involving digestive system; pain in esophagus (finding); absent deglutition; swallowing problems; choking sensation; symptom as reason for upper g.i. examination; dysphagia, pharyngeal phase; dysphagia, pharyngoesophageal phase

MGI Mouse Phenotypes related to Dysphagia:

# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.96 COX10 COX15 DES EPRS1 MEGF10 PABPN1
2 homeostasis/metabolism MP:0005376 9.85 ARID1B COX10 COX15 DES EPRS1 NEB
3 mortality/aging MP:0010768 9.7 ARID1B COX10 COX15 DES EPRS1 NEB
4 muscle MP:0005369 9.17 ARID1B COX10 COX15 DES NEB PABPN1

Drugs & Therapeutics for Dysphagia

Drugs for Dysphagia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 208)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
Remifentanil Approved Phase 4 132875-61-7 60815
Acetaminophen Approved Phase 4 103-90-2 1983
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
13 Pharmaceutical Solutions Phase 4
14 Anesthetics Phase 4
15 Analgesics, Non-Narcotic Phase 4
16 Anesthetics, Local Phase 4
17 Carboxymethylcellulose Sodium Phase 4
18 Antipyretics Phase 4
19 Protective Agents Phase 4
20 Analgesics Phase 4
21 Narcotics Phase 4
22 Analgesics, Opioid Phase 4
23 Cardiotonic Agents Phase 4
24 Angiotensin-Converting Enzyme Inhibitors Phase 4
protease inhibitors Phase 4
26 HIV Protease Inhibitors Phase 4
27 Antihypertensive Agents Phase 4
Chlorhexidine Approved, Vet_approved Phase 3 55-56-1 2713 9552079
Rabeprazole Approved, Investigational Phase 2, Phase 3 117976-89-3 5029
Fluorouracil Approved Phase 3 51-21-8 3385
Ketorolac Approved Phase 3 74103-06-3, 66635-83-4 3826
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
Polaprezinc Experimental Phase 3 107667-60-7
34 Chlorhexidine gluconate Phase 3
35 Anti-Infective Agents, Local Phase 3
36 Antibiotics, Antitubercular Phase 3
37 Disinfectants Phase 3
38 Immunosuppressive Agents Phase 3
39 Immunologic Factors Phase 3
40 Antimetabolites Phase 3
41 Cyclooxygenase Inhibitors Phase 3
42 Antirheumatic Agents Phase 3
43 Anti-Inflammatory Agents, Non-Steroidal Phase 3
44 abobotulinumtoxinA Phase 2, Phase 3
45 Cholinergic Agents Phase 2, Phase 3
46 Botulinum Toxins Phase 2, Phase 3
47 Botulinum Toxins, Type A Phase 2, Phase 3
Menthol Approved Phase 2 2216-51-5 16666
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
Modafinil Approved, Investigational Phase 2 68693-11-8 4236

Interventional clinical trials:

(show top 50) (show all 443)
# Name Status NCT ID Phase Drugs
1 Neuromuscular Electroestimulation and Respiratory Muscle Training in the Management of Dysphagia of Subacute Stroke Patients Completed NCT02473432 Phase 4
2 Effect of Pharyngeal Inhibition Induced by Repetitive Transcranial Stimulation in Post Stroke Dysphagia Completed NCT01081444 Phase 4
3 Pediatric Dysphagia Outcomes After Injection Laryngoplasty for Type I Laryngeal Cleft Completed NCT01507207 Phase 4
4 Evaluation of Two Different Thickening Products in Patients With Dysphagia Completed NCT01651975 Phase 4
5 Peritonsillar Infiltration With Levobupivacaine for Relief of Posttonsillectomy Pain: Does Concentration Have Any Effect? Completed NCT02322346 Phase 4 Group LL;Group HL
6 Does Opioid Induced Swallowing Difficulty Lead to Elevated Risk for Pulmonary Aspiration? Completed NCT01495377 Phase 4 Remifentanil;Placebo;Technetium
7 Efficacy of IV vs Oral Administration of Acetaminophen for Pain Control Following Tonsillectomy With or Without Adenoidectomy Completed NCT01721486 Phase 4 IV acetaminophen;PO acetaminophen
8 Comparing Hemodynamic Changes for Intubation With Shikani Intubating Stylet and Macintosh Laryngoscope Completed NCT01271543 Phase 4
9 Impact of Single Dose Perioperative Steroids on Dysphagia Following Anterior Cervical Spine Surgery: A Randomized, Prospective, Double-Blind Study Recruiting NCT03711474 Phase 4 Dexamethasone;Saline
10 A Pilot Study Assessing the Efficacy of Steroids in the Treatment of Achalasia Enrolling by invitation NCT01903486 Phase 4 Apo-Prednisone Cordorol, Detasone - Prednisone
11 A Randomized Placebo Controlled Trial of Low Dose Angiotensin Converting Enzyme Inhibitor to Prevent Pneumonia in Older People Who Require Tube Feeding Because of Neurological Dysphagia Terminated NCT02358642 Phase 4 Angiotensin converting enzyme inhibitor (Lisinopril);Placebo
12 Use of Xtampza ER to Overcome Difficulties in Swallowing Opioid Pills Terminated NCT03588806 Phase 4 Xtampza ER (oxycodone)
13 The Comparison of Value of Brachytherapy and Endoscopic Stenting With SEMS in Palliative Treatment of Dysphagia Resulting From Adenocarcinoma of the Esophago-Gastric Junction Unknown status NCT01786278 Phase 2, Phase 3
14 Self-Expandable Esophageal Radiation Stent:a Multicentric Randomized Controlled Trial in Patients With Advanced Esophageal Cancer Unknown status NCT01054274 Phase 3
15 Evaluation of the Effect of the Consumption of a Hypercaloric/Hyperproteic Formula in the Coverage of Nutritional Requirements in Patients With Chewing/Swallowing Problems That Require a Shredded Diet. Unknown status NCT03727191 Phase 3
16 Impact of Early Percutaneous Tracheostomy on the Incidence of Swallowing Dysfunction in Critically Ill Patients on Mechanical Ventilation. A Randomized Clinical Trial Unknown status NCT01268423 Phase 3
17 Predicting Oral Care Before Percutaneous Endoscopic Gastrostomy (PEG). The Influence of Oral Hygiene on Local Wound and Systemic Infection in Patients With PEG Placement Unknown status NCT00859235 Phase 3 Chlorhexidine gluconate 0.2%
18 A Randomized, Prospective Trial of Electrosurgical Incision Followed by Rabeprazole Versus Bougie Dilation Followed by Rabeprazole of Symptomatic Lower Esophageal (Schatzki's) Rings Completed NCT00204750 Phase 2, Phase 3
19 Study for the Evaluation of the Impact of HEPILOR on the Possible Delay in the Development of Dysphagia in Breast Cancer Patients Undergoing Adjuvant Radiotherapy on the Breast/Thoracic Wall and Lymph Node Drainage. Completed NCT03997188 Phase 3
20 A Randomised Controlled Trial of Dysphagia Therapies for Swallowing Disorders Following Stroke. Completed NCT00257764 Phase 2, Phase 3
21 The Effects of Intraoperative Local and Systemic Corticosteroid Administration on Postoperative Dysphagia After Anterior Cervical Fusion Completed NCT03311425 Phase 3 Methylprednisolone;Dexamethasone
22 Muscle Preservation and Swallow Function Following Radiotherapy: A Dose Response Study Completed NCT01279837 Phase 2, Phase 3
23 A Randomized Controlled Trial of NMES vs. Traditional Dysphagia Therapy After Stroke Completed NCT01279824 Phase 2, Phase 3
24 A Randomised Phase III Study in Advanced Oesophageal Cancer to Compare Quality of Life and Palliation of Dysphagia in Patients Treated With Radiotherapy vs ChemoRadiotherapy. Completed NCT00193882 Phase 3 Cisplatin;5-Fluorouracil
25 Palliative Radiotherapy in Addition to Self-expanding Metal Stent for Improving Dysphagia and Survival in Advanced Oesophageal Cancer: ROCS (Radiotherapy After Oesophageal Cancer Stenting) Study. Completed NCT01915693 Phase 3
26 A Phase 2b/3 Prospective, Randomized, Double-Blind, Sham-Controlled 3-Part Trial of VTS-270 (2-hydroxypropyl-β-cyclodextrin) in Subjects With Neurologic Manifestations of Niemann-Pick Type C1 (NPC1) Disease Active, not recruiting NCT02534844 Phase 2, Phase 3 VTS-270
27 The Effect of Intravenous Non-steroidal Anti-inflammatory Drugs and Intravenous Corticosteroids on the Likelihood of Dysphagia and Dysphonia Following Anterior Cervical Discectomy and Fusion Not yet recruiting NCT04650893 Phase 3 Intravenous Ketorolac;Intravenous Dexamethasone;Placebo
28 Efficacy and Safety of Onabotulinum Toxin A (Botox) Injections in the Upper Esophageal Sphincter for the Treatment of Pharyngo-esophageal Dysphagia Due to Cricopharyngeal Dysfunction- A Randomized Double Blinded Placebo Controlled Trial Not yet recruiting NCT04695600 Phase 2, Phase 3 Botulinum Toxin Type A Injection [Botox]
29 Effect of Intravenous Corticosteroid Injections on Dysphagia After Anterior Cervical Spine Surgery: a Randomized, Double-blind, Placebo-controlled Study Terminated NCT02266797 Phase 3 Dexamethasone
30 Evaluation of Transcutaneous Electrical Stimulation in Post Stroke Dysphagia Terminated NCT01971320 Phase 3
31 Palliation of Dysphagia in Patients With Advanced Cancer of the Oesophagus by Comparing Stent Followed by 3 Courses of Brachytherapy With 3 Courses of Brachytherapy Only. A Randomised Phase III Study (PACO) Terminated NCT00653107 Phase 3
32 Phase 2 Study of rTMS on Poststroke Dysphagia Unknown status NCT02090231 Phase 2
33 Swallowing Rehabilitation of Dysphagic Tracheostomized Patients Under Mechanical Ventilation at Intensive Care Unit Unknown status NCT01496924 Phase 2
34 Effectiveness of Acupuncture-like Transcutaneous Nerve Stimulation (ALTENS) in Improving Dysphagia and Associated Symptoms of Chemotherapy and/or Intensity Modulated Radiation Therapy (IMRT) for Head and Neck Cancers: A Pilot Study Unknown status NCT01697891 Phase 1, Phase 2
35 Phase II Randomized Trial of Prophylactic Manuka Honey for the Reduction of Chemoradiation Therapy Induced Esophagitis-Related Pain During the Treatment of Lung Cancer Completed NCT01262560 Phase 2 Manuka honey in liquid form;Manuka honey in lozenge form;Standard supportive care
36 A Phase 2 Study to Evaluate the Efficacy and Safety of Palifermin (Recombinant Human Keratinocyte Growth Factor) in the Reduction of Dysphagia in Patients Receiving Concurrent Chemoradiotherapy Followed by Consolidation Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer (NSCLC) Completed NCT00094861 Phase 2 Palifermin;Placebo;Paclitaxel;Carboplatin
37 Effectiveness of a New Neuromuscular Electrical Stimulation (NMES) Treatment Technique (VitalStim® Therapy) in the Management of Young Infants With Severe Dysphagia: a Prospective Pilot Study Completed NCT01723358 Phase 2
38 Cough and Swallow Rehabilitation Following Stroke Completed NCT01907321 Phase 1, Phase 2 Measures performed on all subjects
39 Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging Completed NCT03050957 Phase 2
40 Effect of Natural Agonists of TRPV1 in the Treatment of Functional Oropharyngeal Dysphagia in Neurological Diseases and the Elderly: Piperine Completed NCT01383694 Phase 1, Phase 2 Piperine
41 A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia Completed NCT00376506 Phase 2
42 Effects of Age and Age-Related Diseases on Swallowing Completed NCT00038350 Phase 2
43 Respiratory-Swallow Training in Veterans With Oropharyngeal Cancer Completed NCT01032928 Phase 2
44 Effect of Afferent Oropharyngeal Pharmacological and Electrical Stimulation on Swallow Response and on Activation of Human Cortex in Stroke Patients With Oropharyngeal Dysphagia (OD). A Randomized Controlled Trial. Completed NCT01777672 Phase 2
45 Pilot Study of Transcranial Direct Current Stimulation for Facilitating Swallowing Improvement After an Acute Unilateral Hemispheric Infarction Completed NCT01132066 Phase 1, Phase 2
46 Tongue Pressure Profile Training for Dysphagia Post Stroke Completed NCT01370083 Phase 2
47 Efficacy of Functional Electrical Stimulation in Dysphagia of Nasopharyngeal Cancer Post Radiotherapy Completed NCT00815087 Phase 2
48 Swallow Exercise as Prophylaxis of Dysphagia After Radiotherapy Completed NCT00332865 Phase 1, Phase 2
49 Induction of Volitional Swallowing in Chronic Dysphagia Post Stroke: A Novel Mechanism-Based Intervention Completed NCT00306501 Phase 2
50 Identifying and Treating Arousal Related Deficits in Neglect and Dysphagia Completed NCT01085903 Phase 2 Modafinil;Placebo

Search NIH Clinical Center for Dysphagia

Genetic Tests for Dysphagia

Genetic tests related to Dysphagia:

# Genetic test Affiliating Genes
1 Dysphagia 29

Anatomical Context for Dysphagia

MalaCards organs/tissues related to Dysphagia:

Tongue, Colon, Cortex, Salivary Gland, Lymph Node, Spinal Cord, Tonsil

Publications for Dysphagia

Articles related to Dysphagia:

(show top 50) (show all 28947)
# Title Authors PMID Year
A de novo PABPN1 germline mutation in a patient with oculopharyngeal muscular dystrophy. 54 61
16481821 2006
Oculopharyngeal muscular dystrophy with PABPN1 mutation in a Chinese Malaysian woman. 61 54
15725589 2005
[Oculopharyngeal muscular dystrophy: study of patients from seven Spanish families with different GCG expansions in PABP2 gene]. 54 61
15150706 2004
Spinocerebellar ataxia type 1 (SCA1): phenotype-genotype correlation studies in intermediate alleles. 54 61
11973625 2002
[The clinical characters of myopatic pharyngoparalysis and laryngoparalysis with 3 cases report]. 54 61
12563974 1999
Oculopharyngeal muscular dystrophy: non-French-Canadian pedigrees. 61 54
9585341 1998
Autosomal dominant cerebellar ataxia type I clinical features and MRI in families with SCA1, SCA2 and SCA3. 54 61
8931575 1996
Chondrosarcoma of the parapharyngeal space: Case report and literature review of an extremely rare location. 61
33717391 2021
A novel soft surimi gel with functionality prepared using alcalase for people suffering from dysphagia. 61
33229153 2021
Neuroprotective Effects of Testosterone in Male Wobbler Mouse, a Model of Amyotrophic Lateral Sclerosis. 61
33411236 2021
Astrocytes contribute to the neuronal recovery promoted by high-frequency repetitive magnetic stimulation in in vitro models of ischemia. 61
33522025 2021
Whiplash-Associated Dysphagia and Dysphonia: A Scoping Review. 61
32445061 2021
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial. 61
33794205 2021
Status dystonicus associated with CLN8 disease. 61
33358637 2021
Diagnostic Accuracy of Dysphagia Screening in Stroke Care: Answer to the Letter by Toscano et al. 61
33581987 2021
Hard to Swallow: Dysphagia and Feeding After Ischemic Stroke in Children and Neonates. 61
33641381 2021
Swallowing, Oral Motor, Motor Speech, and Language Impairments Following Acute Pediatric Ischemic Stroke. 61
33641384 2021
Surface Electromyographic Biofeedback and the Effortful Swallow Exercise for Stroke-Related Dysphagia and in Healthy Ageing. 61
32445060 2021
A Nationwide Multi-Center Questionnaire Survey on the Real-World State and Issues Regarding Post-Stroke Complications in Japan. 61
33571877 2021
Clinical and anatomopathological aspects of Stryphnodendron fissuratum poisoning in cattle and sheep. 61
33524427 2021
A case of eosinophilic esophagitis with autoimmune polyendocrine syndrome type 2, including autoimmune gastritis. 61
33411318 2021
Improvements in Dysphagia and Pain With Swallowing in Patients With Eosinophilic Esophagitis Receiving Budesonide Oral Suspension. 61
32272243 2021
Vocal Fold Motion Impairment Following Chemotherapy Administration: Case Reports and Review of the Literature. 61
33501843 2021
Repair of post-bariatric surgery, recurrent, and de novo hiatal hernias improves bloating, abdominal pain, regurgitation, and food intolerance. 61
33483233 2021
Tracking Hyoid Bone Displacement During Swallowing Without Videofluoroscopy Using Machine Learning of Vibratory Signals. 61
32419103 2021
Moving Forward with Dysphagia Care: Implementing Strategies during the COVID-19 Pandemic and Beyond. 61
32519150 2021
Dysphagia Care Across the Continuum: A Multidisciplinary Dysphagia Research Society Taskforce Report of Service-Delivery During the COVID-19 Global Pandemic. 61
32654059 2021
The role of electrochemotherapy with intratumoral bleomycin for early tongue carcinoma. 61
33591860 2021
Lactose Sensitivity and Lactose Malabsorption: The 2 Faces of Lactose Intolerance. 61
33361550 2021
A Rare and Unusual Cause of Tenth Cranial Nerve Palsy Leading to Dysphagia. 61
33811519 2021
Dysphagia Induced by Acromegalic Arthropathy. 61
33116014 2021
Effect of Topical Steroid on Swallowing Following ACDF: Results of a Prospective Double-Blind Randomized Control Trial. 61
33273438 2021
Bronchial fistula and esophageal stricture following endoscopic trans-gastric drainage for a mediastinal pancreatic pseudocyst. 61
33598790 2021
Self-Reported Trismus: prevalence, severity and impact on quality of life in oropharyngeal cancer survivorship: a cross-sectional survey report from a comprehensive cancer center. 61
32779007 2021
The Dysphagia in Multiple Sclerosis Questionnaire Correlates with Fiber-Optic Endoscopic Examination for Detecting Swallowing Deficits in MS. 61
32355992 2021
Impact of gastrointestinal symptoms on quality of life in MEN2. 61
33171530 2021
A Prospective Evaluation of Swallowing and Speech in Patients with Neurofibromatosis Type 2. 61
33777639 2021
Laparoscopic Heller myotomy or pneumatic dilatation in achalasia: results of a prospective, randomized study with at least a decade of follow-up. 61
32303839 2021
[Functional Exams in the gastroenterology - new developments and tips for the common practice]. 61
33780988 2021
Surgical rehabilitation of swallowing with polydimethylsiloxane injections after open partial horizontal laryngectomy: Long-term functional results and quality of life. 61
33355954 2021
Laryngeal Injury and Upper Airway Symptoms After Endotracheal Intubation During Surgery: A Systematic Review and Meta-analysis. 61
33196479 2021
Association between swallowing function and muscle strength in elderly individuals with dysphagia. 61
32978005 2021
[Outcome of Phoniatric Rehabilitation of Dysphagia in Patients with Head and Neck Cancer]. 61
33513621 2021
Ventrally exophytic pontine mass in a patient with dysarthria, dysphagia and diplopia - Question. 61
33612415 2021
Does Local Steroid Reduce Dysphagia After Cervical Disc Replacement? A Prospective, Randomized, Placebo-controlled, Double-blinded Study. 61
33797427 2021
Dysphagia and Epigastric Pain in an Adolescent Boy. 61
33795468 2021
Letter to the Editor in Reference to the Article Entitled "Effects of Carbonated Liquids on Oropharyngeal Swallowing Measures in People with Neurogenic Dysphagia". 61
32430589 2021
An Uncommon Cause of Esophageal Dysphagia and Food Impaction. 61
32772150 2021
Pharyngeal Swallowing Pressures in Patients with Radiation-Associated Dysphagia. 61
32415490 2021
A Prospective Cohort Study of Dysphagia After Subaxial Cervical Spine Surgery. 61
33306616 2021

Variations for Dysphagia

ClinVar genetic disease variations for Dysphagia:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NEB , RIF1 NM_001271208.2(NEB):c.24632_24633del (p.Pro8211fs) Deletion Pathogenic 265493 rs555445835 GRCh37: 2:152350726-152350727
GRCh38: 2:151494212-151494213
2 ARID1B NM_020732.3(ARID1B):c.5968C>T (p.Arg1990Ter) SNV Pathogenic 210306 rs797045283 GRCh37: 6:157528243-157528243
GRCh38: 6:157207109-157207109
3 ZGRF1 NM_001350397.1(ZGRF1):c.3420_3421CT[1] (p.Ser1141fs) Microsatellite Uncertain significance 374091 rs1057518892 GRCh37: 4:113508616-113508617
GRCh38: 4:112587460-112587461
4 DNMT1 NM_001130823.3(DNMT1):c.2718C>G (p.Phe906Leu) SNV Uncertain significance 373927 rs1057518774 GRCh37: 19:10259562-10259562
GRCh38: 19:10148886-10148886
5 SLC6A3 NM_001044.5(SLC6A3):c.1139_1150del (p.Gly380_Lys384delinsGlu) Deletion Uncertain significance 692102 rs1579709871 GRCh37: 5:1414812-1414823
GRCh38: 5:1414697-1414708

Expression for Dysphagia

Search GEO for disease gene expression data for Dysphagia.

Pathways for Dysphagia

GO Terms for Dysphagia

Cellular components related to Dysphagia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial nucleoid GO:0042645 9.16 TWNK POLG
2 contractile fiber GO:0043292 8.96 NEB DES
3 cytochrome complex GO:0070069 8.62 COX15 COX10

Biological processes related to Dysphagia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 9.4 NEB DES
2 heme biosynthetic process GO:0006783 9.37 COX15 COX10
3 mitochondrial electron transport, cytochrome c to oxygen GO:0006123 9.32 COX15 COX10
4 cellular respiration GO:0045333 9.26 COX15 COX10
5 mitochondrial DNA replication GO:0006264 9.16 TWNK POLG
6 respiratory chain complex IV assembly GO:0008535 8.96 COX15 COX10
7 heme a biosynthetic process GO:0006784 8.62 COX15 COX10

Molecular functions related to Dysphagia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytochrome-c oxidase activity GO:0004129 8.62 COX15 COX10

Sources for Dysphagia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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