MCID: EF001
MIFTS: 30

Eaf

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Eaf

MalaCards integrated aliases for Eaf:

Name: Eaf 53
Eosinophilic Angiocentric Fibrosis 53 59
Igg4-Related Eosinophilic Angiocentric Fibrosis 59
Sinonasal Eosinophilic Angiocentric Fibrosis 53

Characteristics:

Orphanet epidemiological data:

59
eosinophilic angiocentric fibrosis
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA449566
ICD10 via Orphanet 34 J39.8

Summaries for Eaf

MalaCards based summary : Eaf, also known as eosinophilic angiocentric fibrosis, is related to deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures syndrome and leopard syndrome. An important gene associated with Eaf is AFF2 (AF4/FMR2 Family Member 2). The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and spleen.

Related Diseases for Eaf

Diseases related to Eaf via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures syndrome 11.0
2 leopard syndrome 11.0
3 aging 10.1
4 sinusitis 9.9
5 orbital granuloma 9.9
6 lacrimal duct obstruction 9.9
7 optic nerve disease 9.9
8 compartment syndrome 9.9
9 neuropathy 9.9
10 idiopathic hypertrophic pachymeningitis 9.9
11 igg4-related pachymeningitis 9.9
12 asthma 9.9
13 mastitis 9.9
14 lymphoblastic leukemia 9.0 AFF1 AFF4

Graphical network of the top 20 diseases related to Eaf:



Diseases related to Eaf

Symptoms & Phenotypes for Eaf

Drugs & Therapeutics for Eaf

Drugs for Eaf (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2 Angiogenesis Inhibitors Phase 2,Phase 1
3 Angiogenesis Modulating Agents Phase 2,Phase 1
4
Apremilast Approved, Investigational Phase 1 608141-41-9 11561674
5 Analgesics Phase 1
6 Analgesics, Non-Narcotic Phase 1
7 Peripheral Nervous System Agents Phase 1
8 Anti-Bacterial Agents Phase 1
9 Immunosuppressive Agents Phase 1
10 Anti-Infective Agents Phase 1
11 Anti-Inflammatory Agents Phase 1
12 Anti-Inflammatory Agents, Non-Steroidal Phase 1
13 Antirheumatic Agents Phase 1
14 Cola Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 DSC-MRI in Measuring Relative Cerebral Blood Volume for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma Recruiting NCT03115333 Phase 2
2 Study to Evaluate Pharmacokinetics of Apremilast in Heatlhy Male Subjects Completed NCT02236988 Phase 1 Apremilast
3 Study of Ventilatory Mechanics in Patients With Sickle Cell Anemia Completed NCT02565849
4 BowelScope: Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities Recruiting NCT03072472 Not Applicable

Search NIH Clinical Center for Eaf

Genetic Tests for Eaf

Anatomical Context for Eaf

MalaCards organs/tissues related to Eaf:

41
Bone, Testes, Spleen, Lung

Publications for Eaf

Articles related to Eaf:

(show top 50) (show all 62)
# Title Authors Year
1
Structure function characterization of the ELL Associated Factor (EAF) from Schizosaccharomyces pombe. ( 29032152 )
2018
2
Ocular involvement in idiopathic hypertrophic pachymeningitis associated with eosinophilic angiocentric fibrosis: a case report. ( 29924200 )
2018
3
Granuloma Faciale and Eosinophilic Angiocentric Fibrosis: Similar Entities in Different Anatomic Sites. ( 26808128 )
2017
4
A Concomitant Case of Orbital Granuloma Faciale and Eosinophilic Angiocentric Fibrosis. ( 27281484 )
2016
5
Health status of male steel workers at an electric arc furnace (EAF) in Trentino, Italy. ( 26900394 )
2016
6
Studies on Antifungal Potential, Primary Characterization and Mode of Action of a De Novo Cytoplasmic Protein (EAF) from Human Commensal Escherichia coli Against Aspergillus spp. ( 26235093 )
2015
7
Eosinophilic Angiocentric Fibrosis of Sinonasal Region: A Rare &amp;amp; Under Reported Entity. ( 26674883 )
2015
8
Orbital Compartment Syndrome in Eosinophilic Angiocentric Fibrosis. ( 24828962 )
2015
9
Genetic analysis of enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid reveals a new deletion within the EAF probe sequence among O119 typical EPEC strains. ( 26438110 )
2015
10
Eosinophilic angiocentric fibrosis presenting as asymptomatic cutaneous nodules. ( 25196473 )
2015
11
A Study on Suitability of EAF Oxidizing Slag in Concrete: An Eco-Friendly and Sustainable Replacement for Natural Coarse Aggregate. ( 26421315 )
2015
12
CO2 sequestration using accelerated gas-solid carbonation of pre-treated EAF steel-making bag house dust. ( 25846002 )
2015
13
Nasal Eosinophilic Angiocentric Fibrosis with Orbital Extension. ( 25601283 )
2015
14
A surgical case of eosinophilic angiocentric fibrosis of the lung. ( 26366349 )
2015
15
Hydrometallurgical extraction of zinc from CaO treated EAF dust in ammonium chloride solution. ( 26448494 )
2015
16
Optic neuropathy secondary to eosinophilic angiocentric fibrosis. ( 25232841 )
2015
17
Eosinophilic angiocentric fibrosis of the orbit: a case report and review of literature. ( 25673599 )
2015
18
Study on simultaneous recycling of EAF dust and plastic waste containing TBBPA. ( 24945793 )
2014
19
Characterisation of the sintering behaviour of Waelz slag from electric arc furnace (EAF) dust recycling for use in the clay ceramics industry. ( 24321287 )
2014
20
Primary orbital eosinophilic angiocentric fibrosis with intranasal extension. ( 23733241 )
2014
21
Recycling of Malaysia's electric arc furnace (EAF) slag waste into heavy-duty green ceramic tile. ( 25242607 )
2014
22
Eosinophilic angiocentric fibrosis of the nose and sinuses. ( 25399547 )
2014
23
Accelerated ageing of an EAF black slag by carbonation and percolation for long-term behaviour assessment. ( 24726964 )
2014
24
Unexplained persistent dyspnea in a young woman with eosinophilic angiocentric fibrosis. ( 24149671 )
2014
25
Crystallization Control for Remediation of an FetO-rich CaO-SiO2-Al2O3-MgO EAF Waste Slag. ( 24410350 )
2014
26
The efficiency of quartz addition on electric arc furnace (EAF) carbon steel slag stability. ( 25113518 )
2014
27
Reduction behavior of zinc ferrite in EAF-dust recycling with CO gas as a reducing agent. ( 24921184 )
2014
28
Sinonasal eosinophilic angiocentric fibrosis: a systematic review. ( 25065665 )
2014
29
Eosinophilic angiocentric fibrosis of the nasal septum. ( 23634315 )
2013
30
Heavy metal adsorption changes of EAF steel slag after phosphorus adsorption. ( 22508118 )
2012
31
Eosinophilic angiocentric fibrosis is a form of IgG4-related systemic disease. ( 21502911 )
2011
32
Granuloma faciale with subglottic eosinophilic angiocentric fibrosis: case report and review of the literature. ( 21916274 )
2011
33
Nasal cavity eosinophilic angiocentric fibrosis: CT and MR imaging findings. ( 21998106 )
2011
34
Intranasal eosinophilic angiocentric fibrosis: a case report and review. ( 20533005 )
2010
35
Eosinophilic angiocentric fibrosis of orbit. ( 21045443 )
2010
36
Virulence features of atypical enteropathogenic Escherichia coli identified by the eae(+) EAF-negative stx(-) genetic profile. ( 19442475 )
2009
37
Reproducing ten years of road ageing--accelerated carbonation and leaching of EAF steel slag. ( 19539979 )
2009
38
The use of EAF dust in cement composites: assessment of environmental impact. ( 19097693 )
2009
39
Pathology quiz case 2. Eosinophilic angiocentric fibrosis (EAF). ( 19620599 )
2009
40
A novel method to enhance polychlorinated dibenzo-p-dioxins and dibenzofurans removal by adding bio-solution in EAF dust treatment plant. ( 17532560 )
2008
41
Eosinophilic angiocentric fibrosis of the orbit. ( 18412598 )
2008
42
Role of extension arm in PEG-Hb conjugates on the stability of the tetramer: non-conservative EAF maleimide thio-PEG mediated PEGylation. ( 19085194 )
2008
43
New evidence for rejuvenation of phosphorus retention capacity in EAF steel slag. ( 18767686 )
2008
44
Eosinophilic angiocentric fibrosis: an unusual entity producing complete lacrimal duct obstruction. ( 16754230 )
2006
45
Use of EAF dust as heterogeneous catalyst in Fenton oxidation of PCP contaminated wastewaters. ( 16621261 )
2006
46
Hydrometallurgical processing of carbon steel EAF dust. ( 16442223 )
2006
47
Study of the presence of fluorine in the recycled fractions during carbothermal treatment of EAF dust. ( 12909089 )
2003
48
Combined glassification of EAF dust and incinerator fly ash. ( 12656228 )
2003
49
O-serogroups, eae gene and EAF plasmid in Escherichia coli isolates from cases of bovine mastitis in Brazil. ( 11844619 )
2002
50
Interactions of Escherichia coli strains of non-EPEC serogroups that carry eae and lack the EAF and stx gene sequences with undifferentiated and differentiated intestinal human Caco-2 cells. ( 11410359 )
2001

Variations for Eaf

Expression for Eaf

Search GEO for disease gene expression data for Eaf.

Pathways for Eaf

GO Terms for Eaf

Cellular components related to Eaf according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.73 AFF1 AFF2 AFF3 AFF4 EAF1 EAF2
2 transcription elongation factor complex GO:0008023 9.43 AFF1 AFF2 AFF3 AFF4 EAF1 EAF2
3 nuclear speck GO:0016607 9.33 AFF2 EAF1 EAF2
4 ELL-EAF complex GO:0032783 9.1 AFF1 AFF2 AFF3 AFF4 EAF1 EAF2

Biological processes related to Eaf according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription, DNA-templated GO:0006351 9.56 AFF3 AFF4 EAF1 EAF2
2 regulation of transcription, DNA-templated GO:0006355 9.35 AFF1 AFF3 AFF4 EAF1 EAF2
3 transcription by RNA polymerase II GO:0006366 9.33 AFF4 EAF1 EAF2
4 transcription elongation from RNA polymerase II promoter GO:0006368 8.8 AFF4 EAF1 EAF2

Molecular functions related to Eaf according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding transcription factor activity GO:0003700 9.26 AFF1 AFF2 AFF3 AFF4
2 double-stranded DNA binding GO:0003690 8.92 AFF1 AFF2 AFF3 AFF4

Sources for Eaf

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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