EAF
MCID: EF001
MIFTS: 26

Eaf (EAF)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Eaf

MalaCards integrated aliases for Eaf:

Name: Eaf 53
Eosinophilic Angiocentric Fibrosis 53 59
Igg4-Related Eosinophilic Angiocentric Fibrosis 59
Sinonasal Eosinophilic Angiocentric Fibrosis 53

Characteristics:

Orphanet epidemiological data:

59
eosinophilic angiocentric fibrosis
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA449566
ICD10 via Orphanet 34 J39.8

Summaries for Eaf

MalaCards based summary : Eaf, also known as eosinophilic angiocentric fibrosis, is related to deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures syndrome and leopard syndrome. An important gene associated with Eaf is AFF2 (AF4/FMR2 Family Member 2). The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin.

Related Diseases for Eaf

Diseases related to Eaf via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures syndrome 11.1
2 leopard syndrome 11.1
3 asthma 10.1
4 mastitis 10.1
5 orbital granuloma 10.0
6 lacrimal duct obstruction 10.0
7 optic nerve disease 10.0
8 compartment syndrome 10.0
9 neuropathy 10.0
10 idiopathic hypertrophic pachymeningitis 10.0
11 igg4-related pachymeningitis 10.0

Graphical network of the top 20 diseases related to Eaf:



Diseases related to Eaf

Symptoms & Phenotypes for Eaf

Drugs & Therapeutics for Eaf

Drugs for Eaf (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2 Angiogenesis Inhibitors Phase 2,Phase 1
3 Angiogenesis Modulating Agents Phase 2,Phase 1
4
Apremilast Approved, Investigational Phase 1 608141-41-9 11561674
5 Anti-Bacterial Agents Phase 1
6 Analgesics Phase 1
7 Immunologic Factors Phase 1
8 Analgesics, Non-Narcotic Phase 1
9 Anti-Inflammatory Agents, Non-Steroidal Phase 1
10 Anti-Inflammatory Agents Phase 1
11 Anti-Infective Agents Phase 1
12 Immunosuppressive Agents Phase 1
13 Antirheumatic Agents Phase 1
14 Peripheral Nervous System Agents Phase 1
15 Cola Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 DSC-MRI in Measuring Relative Cerebral Blood Volume for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma Recruiting NCT03115333 Phase 2
2 Study to Evaluate Pharmacokinetics of Apremilast in Heatlhy Male Subjects Completed NCT02236988 Phase 1 Apremilast
3 Study of Ventilatory Mechanics in Patients With Sickle Cell Anemia Completed NCT02565849
4 BowelScope: Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities Completed NCT03072472 Not Applicable

Search NIH Clinical Center for Eaf

Genetic Tests for Eaf

Anatomical Context for Eaf

MalaCards organs/tissues related to Eaf:

41
Bone, Lung, Skin, Testes, Spleen, Trachea

Publications for Eaf

Articles related to Eaf:

(show top 50) (show all 98)
# Title Authors Year
1
Structure function characterization of the ELL Associated Factor (EAF) from Schizosaccharomyces pombe. ( 29032152 )
2018
2
Ocular involvement in idiopathic hypertrophic pachymeningitis associated with eosinophilic angiocentric fibrosis: a case report. ( 29924200 )
2018
3
Selective metal cation concentration during the solidification of stainless steel EAF dust and slag mixtures from high temperatures for increased Cr recovery. ( 30029087 )
2018
4
Image Gallery: Concomitant eosinophilic angiocentric fibrosis and granuloma faciale. ( 29897116 )
2018
5
Eosinophilic angiocentric fibrosis : a sino-orbital masquerader. ( 30093462 )
2018
6
Eosinophilic Angiocentric Fibrosis: A Review and Update of Its Association With Immunoglobulin G4-Related Disease. ( 30289267 )
2018
7
Granuloma Faciale and Eosinophilic Angiocentric Fibrosis: Similar Entities in Different Anatomic Sites. ( 26808128 )
2017
8
Eosinophilic Angiocentric Fibrosis as a Stenosing Lesion in the Subglottis. ( 28251006 )
2017
9
Right ethmoid eosinophilic angiocentric fibrosis with orbital extension. ( 28359733 )
2017
10
A Case Report and Systematic Review of Eosinophilic Angiocentric Fibrosis of the Paranasal Sinuses. ( 28397561 )
2017
11
An unusual presentation of eosinophilic angiocentric fibrosis. ( 29250311 )
2017
12
A Concomitant Case of Orbital Granuloma Faciale and Eosinophilic Angiocentric Fibrosis. ( 27281484 )
2016
13
Health status of male steel workers at an electric arc furnace (EAF) in Trentino, Italy. ( 26900394 )
2016
14
Eosinophilic angiocentric fibrosis of the sinonasal tract. ( 30363608 )
2016
15
Studies on Antifungal Potential, Primary Characterization and Mode of Action of a De Novo Cytoplasmic Protein (EAF) from Human Commensal Escherichia coli Against Aspergillus spp. ( 26235093 )
2015
16
Eosinophilic Angiocentric Fibrosis of Sinonasal Region: A Rare &amp;amp; Under Reported Entity. ( 26674883 )
2015
17
Orbital Compartment Syndrome in Eosinophilic Angiocentric Fibrosis. ( 24828962 )
2015
18
Genetic analysis of enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid reveals a new deletion within the EAF probe sequence among O119 typical EPEC strains. ( 26438110 )
2015
19
Eosinophilic angiocentric fibrosis presenting as asymptomatic cutaneous nodules. ( 25196473 )
2015
20
A Study on Suitability of EAF Oxidizing Slag in Concrete: An Eco-Friendly and Sustainable Replacement for Natural Coarse Aggregate. ( 26421315 )
2015
21
CO2 sequestration using accelerated gas-solid carbonation of pre-treated EAF steel-making bag house dust. ( 25846002 )
2015
22
Nasal Eosinophilic Angiocentric Fibrosis with Orbital Extension. ( 25601283 )
2015
23
A surgical case of eosinophilic angiocentric fibrosis of the lung. ( 26366349 )
2015
24
Hydrometallurgical extraction of zinc from CaO treated EAF dust in ammonium chloride solution. ( 26448494 )
2015
25
Optic neuropathy secondary to eosinophilic angiocentric fibrosis. ( 25232841 )
2015
26
Eosinophilic angiocentric fibrosis of the orbit: a case report and review of literature. ( 25673599 )
2015
27
Study on simultaneous recycling of EAF dust and plastic waste containing TBBPA. ( 24945793 )
2014
28
Characterisation of the sintering behaviour of Waelz slag from electric arc furnace (EAF) dust recycling for use in the clay ceramics industry. ( 24321287 )
2014
29
Primary orbital eosinophilic angiocentric fibrosis with intranasal extension. ( 23733241 )
2014
30
Recycling of Malaysia's electric arc furnace (EAF) slag waste into heavy-duty green ceramic tile. ( 25242607 )
2014
31
Eosinophilic angiocentric fibrosis of the nose and sinuses. ( 25399547 )
2014
32
Accelerated ageing of an EAF black slag by carbonation and percolation for long-term behaviour assessment. ( 24726964 )
2014
33
Unexplained persistent dyspnea in a young woman with eosinophilic angiocentric fibrosis. ( 24149671 )
2014
34
Crystallization Control for Remediation of an FetO-rich CaO-SiO2-Al2O3-MgO EAF Waste Slag. ( 24410350 )
2014
35
The efficiency of quartz addition on electric arc furnace (EAF) carbon steel slag stability. ( 25113518 )
2014
36
Reduction behavior of zinc ferrite in EAF-dust recycling with CO gas as a reducing agent. ( 24921184 )
2014
37
Sinonasal eosinophilic angiocentric fibrosis: a systematic review. ( 25065665 )
2014
38
Eosinophilic angiocentric fibrosis of the nasal septum. ( 23634315 )
2013
39
Heavy metal adsorption changes of EAF steel slag after phosphorus adsorption. ( 22508118 )
2012
40
Eosinophilic angiocentric fibrosis is a form of IgG4-related systemic disease. ( 21502911 )
2011
41
Granuloma faciale with subglottic eosinophilic angiocentric fibrosis: case report and review of the literature. ( 21916274 )
2011
42
Nasal cavity eosinophilic angiocentric fibrosis: CT and MR imaging findings. ( 21998106 )
2011
43
Regulation of fertility, survival, and cuticle collagen function by the Caenorhabditis elegans eaf-1 and ell-1 genes. ( 21880729 )
2011
44
Intranasal eosinophilic angiocentric fibrosis: a case report and review. ( 20533005 )
2010
45
Eosinophilic angiocentric fibrosis of orbit. ( 21045443 )
2010
46
Virulence features of atypical enteropathogenic Escherichia coli identified by the eae(+) EAF-negative stx(-) genetic profile. ( 19442475 )
2009
47
Reproducing ten years of road ageing--accelerated carbonation and leaching of EAF steel slag. ( 19539979 )
2009
48
The use of EAF dust in cement composites: assessment of environmental impact. ( 19097693 )
2009
49
Pathology quiz case 2. Eosinophilic angiocentric fibrosis (EAF). ( 19620599 )
2009
50
A novel method to enhance polychlorinated dibenzo-p-dioxins and dibenzofurans removal by adding bio-solution in EAF dust treatment plant. ( 17532560 )
2008

Variations for Eaf

Expression for Eaf

Search GEO for disease gene expression data for Eaf.

Pathways for Eaf

GO Terms for Eaf

Cellular components related to Eaf according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.73 AFF1 AFF2 AFF3 AFF4 EAF1 EAF2
2 ELL-EAF complex GO:0032783 9.43 AFF1 AFF2 AFF3 AFF4 EAF1 EAF2
3 nuclear speck GO:0016607 9.33 AFF2 EAF1 EAF2
4 transcription elongation factor complex GO:0008023 9.1 AFF1 AFF2 AFF3 AFF4 EAF1 EAF2

Biological processes related to Eaf according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.33 AFF4 EAF1 EAF2
2 transcription elongation from RNA polymerase II promoter GO:0006368 9.13 AFF4 EAF1 EAF2
3 regulation of transcription, DNA-templated GO:0006355 9.1 AFF1 AFF2 AFF3 AFF4 EAF1 EAF2

Molecular functions related to Eaf according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.26 AFF1 AFF2 AFF3 AFF4
2 double-stranded DNA binding GO:0003690 8.92 AFF1 AFF2 AFF3 AFF4

Sources for Eaf

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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