MCID: ELS001
MIFTS: 49

Eales Disease

Categories: Rare diseases, Eye diseases, Cardiovascular diseases

Aliases & Classifications for Eales Disease

MalaCards integrated aliases for Eales Disease:

Name: Eales Disease 53 59 55 73
Idiopathic Recurrent Vitreal Hemorrhage 53
Idiopathic Obliterative Vasculopathy 53
Idiopathic Retinal Perivasculitis 59
Idiopathic Retinal Vasculitis 59

Characteristics:

Orphanet epidemiological data:

59
eales disease
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA40923
MESH via Orphanet 45 C538011
UMLS via Orphanet 74 C0271073
ICD10 via Orphanet 34 H35.0
UMLS 73 C0271073

Summaries for Eales Disease

NIH Rare Diseases : 53 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. This condition is most common among young males and normally affects both eyes. In most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. Treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. Visual prognosis is good if treatment begins early in the course of the disease. 

MalaCards based summary : Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to retinal vasculitis and choroiditis. An important gene associated with Eales Disease is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Related Diseases for Eales Disease

Diseases related to Eales Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 320)
# Related Disease Score Top Affiliating Genes
1 retinal vasculitis 31.0 NOS2 SAG SOD1
2 choroiditis 30.9 IL10 TNF
3 retinal ischemia 30.2 SOD1 TNF VEGFA
4 macular retinal edema 29.2 IL6 SERPINF1 VEGFA
5 irvan syndrome 12.0
6 punctate inner choroidopathy 10.9 IL10 TNF
7 microscopic polyangiitis 10.8 IL10 TNF
8 multifocal choroiditis 10.8 IL10 TNF
9 transient hypogammaglobulinemia 10.8 IL10 TNF
10 meningitis and encephalitis 10.8 CP SOD1
11 sporotrichosis 10.8 IFNG IL10
12 trichosporonosis 10.8 IFNG TNF
13 chronic beryllium disease 10.7 IFNG TNF
14 granulocytopenia 10.7 CP TNF
15 clonorchiasis 10.7 IFNG IL10 TNF
16 spotted fever 10.6 IFNG IL10 TNF
17 mycoplasmal pneumonia 10.6 IFNG IL4
18 lepromatous leprosy 10.6 IFNG IL10 TNF
19 peyronie disease 10.6 NOS2 SOD1
20 plasmodium falciparum malaria 10.6 IFNG IL10 TNF
21 immunoglobulin a deficiency 1 10.5 IL10 IL4
22 skin sarcoidosis 10.5 SERPINF1 TNF
23 idiopathic achalasia 10.5 IL10 NOS2 TNF
24 melancholia 10.5 TF TNF
25 hemophagocytic lymphohistiocytosis 10.5 IFNG IL10 TNF
26 scorpion envenomation 10.5 IL6 TNF
27 celiac disease 1 10.5 IFNG IL10 TNF
28 retinitis pigmentosa 22 10.4 IL10 IL4
29 primary peritoneal carcinoma 10.4 IFNG IL10 VEGFA
30 leukomalacia 10.4 IL6 TNF
31 eye lymphoma 10.4 IL10 IL6
32 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
33 soft tissue sarcoma 10.4 IFNG TNF VEGFA
34 penicillin allergy 10.4 IFNG IL4
35 acute transverse myelitis 10.4 IL10 IL6
36 hyperlucent lung 10.4 IFNG IL10 IL4
37 tropical endomyocardial fibrosis 10.4 IL10 IL4 TNF
38 baylisascariasis 10.4 IFNG IL10 IL4
39 trichuriasis 10.4 IL10 TNF
40 tungiasis 10.4 IL10 IL4 TNF
41 endomyocardial fibrosis 10.4 IL10 IL4 TNF
42 buruli ulcer 10.4 IFNG IL10 IL4
43 streptococcal toxic-shock syndrome 10.4 IL6 TNF
44 radiation proctitis 10.4 TF TNF VEGFA
45 null-cell leukemia 10.3 IL6 TNF
46 paranasal sinus disease 10.3 IFNG IL10 IL4
47 aceruloplasminemia 10.3 CP SOD1 TF
48 retinitis 10.3
49 lichen disease 10.3 IFNG IL4 TNF
50 nose disease 10.3 IL10 IL4 TNF

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to Eales Disease

Symptoms & Phenotypes for Eales Disease

MGI Mouse Phenotypes related to Eales Disease:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.3 IFNG IL1B IL10 CP NOS2 IL6
2 homeostasis/metabolism MP:0005376 10.29 CP IL10 IFNG IL1B IL4 NOS2
3 cardiovascular system MP:0005385 10.28 CP IL10 IFNG IL1B NOS2 IL6
4 growth/size/body region MP:0005378 10.24 IL10 IFNG IL1B IL6 IL4 NOS2
5 immune system MP:0005387 10.24 CP IL10 IFNG IL1B IL4 NOS2
6 cellular MP:0005384 10.23 CP IL10 IFNG IL6 IL4 NOS2
7 endocrine/exocrine gland MP:0005379 10.2 IL10 IFNG IL4 NOS2 IL6 SERPINF1
8 digestive/alimentary MP:0005381 10.16 IL10 IFNG IL4 NOS2 IL6 SERPINF1
9 integument MP:0010771 10.13 IL10 IFNG IL1B IL4 NOS2 IL6
10 mortality/aging MP:0010768 10.13 IL10 IFNG IL6 IL4 NOS2 IL1B
11 nervous system MP:0003631 10.13 IFNG IL1B IL10 CP NOS2 IL6
12 craniofacial MP:0005382 10.11 IL10 IFNG IL1B IL4 NOS2 TNF
13 liver/biliary system MP:0005370 10.11 IFNG IL10 CP IL4 NOS2 IL6
14 neoplasm MP:0002006 9.97 IFNG IL1B IL10 NOS2 IL6 TNF
15 muscle MP:0005369 9.95 IL10 IFNG NOS2 IL6 TNF SOD1
16 reproductive system MP:0005389 9.91 IL10 IFNG IL4 NOS2 IL6 SERPINF1
17 respiratory system MP:0005388 9.7 IL10 IFNG IL4 NOS2 IL6 TNF
18 skeleton MP:0005390 9.65 IFNG IL1B IL10 IL4 NOS2 IL6
19 vision/eye MP:0005391 9.4 IFNG IL10 CP NOS2 IL6 RBP3

Drugs & Therapeutics for Eales Disease

Drugs for Eales Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 2, Phase 3
3 Angiogenesis Modulating Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lucentis (Ranibizumab) for Eales' Disease Completed NCT00384449 Phase 2, Phase 3 Ranibizumab

Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

Anatomical Context for Eales Disease

MalaCards organs/tissues related to Eales Disease:

41
Retina, Eye, Endothelial, Thyroid, Monocytes

Publications for Eales Disease

Articles related to Eales Disease:

(show top 50) (show all 73)
# Title Authors Year
1
Spectral domain optical coherence tomography evaluation of macular changes in Eales disease. ( 29480258 )
2018
2
Retinal vasculitis and Eales disease. ( 29599058 )
2018
3
Pediatric Eales Disease: An Indian Tertiary Eye Center Experience. ( 29709043 )
2018
4
Unilateral Eales' disease a case report. ( 29450389 )
2017
5
Long-Term Outcomes of a Large Cohort of Patients with Eales' Disease. ( 28448727 )
2017
6
Role of high-resolution computerized tomography chest in identifying tubercular etiology in patients diagnosed as Eales' disease. ( 28101723 )
2017
7
A rare presentation of exudative macroaneurysms in unilateral Eales' disease. ( 29022965 )
2017
8
Eales disease in a young adult man Case report. ( 29516052 )
2017
9
Detection of Mycobacterium tuberculosis with nested polymerase chain reaction analysis in enucleated eye ball in Eales' disease. ( 26499903 )
2016
10
Ultra-wide field angiography in the management of Eales disease. ( 27609162 )
2016
11
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both? ( 26842710 )
2016
12
Eales Disease. ( 28586583 )
2016
13
Localization of Human Copper Transporter 1 in the Eye and its Role in Eales Disease. ( 26807780 )
2016
14
Association of Mycobacterium tuberculosis in the causation of Eales' disease: an institutional experience. ( 25657155 )
2015
15
Angiogenic potential of vitreous from proliferative diabetic retinopathy and eales' disease patients. ( 25310689 )
2014
16
Eales disease: no typical clinical presentation. ( 25374641 )
2014
17
Combination of intravitreal bevacizumab and peripheral photocoagulation: an alternative treatment in eales disease. ( 24600639 )
2013
18
Profiling of human leukocyte antigens in Eales disease and tuberculosis. ( 23386050 )
2013
19
Surgical outcomes of minimally invasive vitrectomy surgery in Eales' disease. ( 24172552 )
2013
20
Eales' disease - current concepts in diagnosis and management. ( 23514227 )
2013
21
Eales' disease with neurological complications. ( 24005742 )
2013
22
Increased homocysteine, homocysteine-thiolactone, protein homocysteinylation and oxidative stress in the circulation of patients with Eales' disease. ( 23761385 )
2013
23
The use of a vascular endothelial growth factor inhibitor (ranibizumab) in macular edema due to eales disease. ( 25390730 )
2012
24
Quantitative polymerase chain reaction for Mycobacterium tuberculosis in so-called Eales' disease. ( 22486260 )
2012
25
Protein-ligand interaction studies of retinol-binding protein 3 with herbal molecules using AutoDock for the management of Eales' disease. ( 24376904 )
2012
26
Eales disease associated with serpiginous choroiditis. ( 23143459 )
2012
27
Intravitreal bevacizumab as an adjunct to vitrectomy in advanced Eales' disease. ( 22089976 )
2012
28
Secondary rhegmatogenous retinal detachment following intravitreal bevacizumab in patients with vitreous hemorrhage or tractional retinal detachment secondary to Eales' disease. ( 22169980 )
2012
29
Vitreopapillary and vitreomacular traction in proliferative Eales' disease. ( 23109416 )
2012
30
Eales' disease following hypothyroidism secondary to Hashimotos thyroiditis. ( 23198627 )
2012
31
Assessment of gelatinase and tumor necrosis factor-I+ level in the vitreous and serum of patients with Eales disease: role of inflammation-mediated angiogenesis in the pathogenesis of Eales disease. ( 21394064 )
2011
32
Role of intravitreal bevacizumab in Eales disease with dense vitreous hemorrhage: a prospective randomized control study. ( 21301382 )
2011
33
Case report: ampiginous chorioretinopathy associated with eales disease in a patient with presumed tuberculosis. ( 25390176 )
2011
34
Association of interferon-gamma, interleukin-10, and tumor necrosis factor-alpha gene polymorphisms with occurrence and severity of Eales' disease. ( 20720222 )
2011
35
Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. ( 21849807 )
2011
36
Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease. ( 22025890 )
2011
37
Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). ( 20973744 )
2010
38
Serum interferon-gamma/interleukin-4 imbalance in patients with Eales' disease. ( 20533927 )
2010
39
Ratio of the vitreous vascular endothelial growth factor and pigment epithelial-derived factor in Eales disease. ( 20072643 )
2009
40
Proinflammatory cytokines and angiogenic and antiangiogenic factors in vitreous of patients with proliferative diabetic retinopathy and Eales' disease (ED). ( 18936719 )
2009
41
Spontaneous relief of vitreomacular traction and regression of neovascularization in eales disease after intravitreal injection of bevacizumab. ( 25391054 )
2009
42
Interleukin-1 and tumor necrosis factor-alpha: novel targets for immunotherapy in Eales disease. ( 19585364 )
2009
43
Intravitreal injection of bevacizumab in Eales disease. ( 18379947 )
2008
44
Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. ( 18536597 )
2008
45
Intravitreal steroids may facilitate treatment of Eales' disease (idiopathic retinal vasculitis): an interventional case series. ( 16980931 )
2007
46
Eales' disease: oxidant stress and weak antioxidant defence. ( 17322597 )
2007
47
Rapid regression of disc and retinal neovascularization in a case of Eales disease after intravitreal bevacizumab. ( 17392871 )
2007
48
Increase in Fe3+/Fe2+ ratio and iron-induced oxidative stress in Eales disease and presence of ferrous iron in circulating transferrin. ( 17852192 )
2007
49
Respiratory disease in the ophthalmology department. Diagnosis: retinal vasculitis associated with tuberculoprotein hypersensitivity (Eales' disease). ( 17536031 )
2007
50
Association of retinal vasculitis (Eales' disease) and Meniere-like vestibulocochlear symptoms. ( 16133465 )
2006

Variations for Eales Disease

Expression for Eales Disease

Search GEO for disease gene expression data for Eales Disease.

Pathways for Eales Disease

Pathways related to Eales Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 IFNG IL10 IL1B IL4 IL6 NOS2
2
Show member pathways
13.51 IFNG IL10 IL1B IL4 IL6 TNF
3
Show member pathways
13.38 IFNG IL10 IL1B IL4 IL6 NOS2
4
Show member pathways
13.03 IFNG IL10 IL1B IL6 NOS2 TNF
5
Show member pathways
12.92 IFNG IL10 IL1B IL4 IL6 TNF
6 12.85 IFNG IL4 IL6 NOS2 VEGFA
7
Show member pathways
12.81 IFNG IL1B IL4 IL6 TNF
8
Show member pathways
12.69 IFNG IL10 IL1B IL4 IL6 TNF
9
Show member pathways
12.64 IFNG IL10 IL1B IL6 NOS2 TNF
10 12.6 IFNG IL10 IL1B IL4 TNF
11
Show member pathways
12.5 IFNG IL10 IL1B IL4 IL6 TNF
12
Show member pathways
12.48 IFNG IL10 IL1B IL4 IL6 TNF
13
Show member pathways
12.4 IFNG IL1B IL4 IL6 TNF
14
Show member pathways
12.38 IFNG IL1B IL4 IL6 SOD1 TNF
15
Show member pathways
12.34 IFNG IL1B IL6 NOS2 TNF
16
Show member pathways
12.33 IFNG IL10 IL1B IL6 TNF
17
Show member pathways
12.29 CP IL1B IL6 NOS2 TNF
18
Show member pathways
12.29 IFNG IL10 IL1B IL4 NOS2 TNF
19 12.26 IFNG IL6 NOS2 TNF VEGFA
20
Show member pathways
12.24 IL10 IL1B IL6 TNF
21 12.24 IFNG IL10 IL1B IL6 NOS2 TNF
22
Show member pathways
12.19 IFNG IL1B IL4 IL6 NOS2 TNF
23 12.17 IL10 IL1B IL6 TF TNF VEGFA
24 12.14 IFNG IL1B TNF VEGFA
25
Show member pathways
12.11 IFNG IL10 IL1B IL4 IL6
26 12.07 IFNG IL10 IL4 IL6 TNF
27
Show member pathways
12.04 IFNG IL1B IL4 NOS2
28 12.02 IFNG IL1B TNF
29 11.98 IL1B IL6 TNF VEGFA
30 11.98 IFNG IL6 NOS2 TF VEGFA
31 11.96 IL1B IL4 IL6 TNF
32 11.96 IFNG IL1B IL4 IL6 NOS2 TNF
33 11.95 IL1B IL6 TNF
34 11.94 IFNG IL1B IL6
35 11.93 IFNG IL1B IL6 TNF VEGFA
36 11.91 IFNG IL1B IL6 NOS2
37 11.86 IFNG IL10 IL1B IL4 TNF
38 11.83 IL10 IL1B IL6 NOS2 TNF
39 11.82 IFNG IL4 IL6
40
Show member pathways
11.79 IFNG IL4 TNF
41 11.79 IFNG IL10 IL1B IL6 TNF
42 11.78 IFNG IL10 IL1B IL6 NOS2 TNF
43 11.77 CP NOS2 TF VEGFA
44 11.76 IL1B IL4 IL6 TNF
45
Show member pathways
11.67 CP NOS2 SOD1
46 11.64 IFNG IL6 NOS2
47 11.63 IL1B IL6 TNF
48 11.61 IFNG IL1B NOS2 TNF
49 11.6 IL6 NOS2 VEGFA
50 11.6 IFNG IL6 TNF

GO Terms for Eales Disease

Cellular components related to Eales Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CP IFNG IL10 IL1B IL4 IL6
2 extracellular space GO:0005615 9.4 CP IFNG IL10 IL1B IL4 IL6
3 secretory granule GO:0030141 9.33 IL1B SOD1 VEGFA

Biological processes related to Eales Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.97 IL10 IL1B IL6 NOS2 TNF
2 positive regulation of gene expression GO:0010628 9.96 IFNG IL1B IL6 TNF VEGFA
3 immune response GO:0006955 9.91 IFNG IL10 IL1B IL4 IL6 TNF
4 platelet degranulation GO:0002576 9.87 SOD1 TF VEGFA
5 activation of MAPK activity GO:0000187 9.87 IL1B SOD1 TNF
6 positive regulation of protein phosphorylation GO:0001934 9.87 IFNG IL1B TNF VEGFA
7 response to organic substance GO:0010033 9.86 IL10 SOD1 TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 IL6 TNF VEGFA
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IFNG IL6 VEGFA
10 response to glucocorticoid GO:0051384 9.82 IL10 IL6 TNF
11 positive regulation of T cell proliferation GO:0042102 9.82 IL1B IL4 IL6
12 cellular iron ion homeostasis GO:0006879 9.81 CP SOD1 TF
13 cellular response to lipopolysaccharide GO:0071222 9.81 IL10 IL6 NOS2 TNF
14 humoral immune response GO:0006959 9.8 IFNG IL6 TNF
15 negative regulation of gene expression GO:0010629 9.8 IFNG NOS2 SERPINF1 TNF VEGFA
16 positive regulation of interleukin-6 production GO:0032755 9.79 IL1B IL6 TNF
17 interleukin-12-mediated signaling pathway GO:0035722 9.78 IFNG IL10 SOD1
18 positive regulation of DNA binding transcription factor activity GO:0051091 9.78 IL10 IL1B IL6 TNF
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.72 IFNG IL1B TNF
20 positive regulation of chemokine production GO:0032722 9.7 IL6 TNF
21 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.7 IL1B VEGFA
22 regulation of signaling receptor activity GO:0010469 9.7 IFNG IL10 IL1B IL4 IL6 TNF
23 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
24 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 TNF
25 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
26 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
27 endothelial cell apoptotic process GO:0072577 9.66 IL10 TNF
28 positive regulation of MHC class II biosynthetic process GO:0045348 9.66 IL10 IL4
29 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
30 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
31 type 2 immune response GO:0042092 9.63 IL10 IL4
32 positive regulation of protein complex assembly GO:0031334 9.63 IFNG TNF VEGFA
33 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
34 regulation of insulin secretion GO:0050796 9.62 IFNG IL1B NOS2 TNF
35 regulation of isotype switching GO:0045191 9.6 IL10 IL4
36 positive regulation of killing of cells of other organism GO:0051712 9.59 IFNG NOS2
37 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
38 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
39 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.54 IFNG IL1B TNF
40 response to carbon monoxide GO:0034465 9.52 IL10 SOD1
41 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 IFNG TNF
42 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.43 IL10 IL1B TNF
43 cytokine-mediated signaling pathway GO:0019221 9.17 IL10 IL1B IL4 IL6 NOS2 TNF
44 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.13 IFNG IL1B TNF
45 positive regulation of transcription by RNA polymerase II GO:0045944 10.16 IL10 IL1B IL4 IL6 TNF VEGFA
46 positive regulation of transcription, DNA-templated GO:0045893 10.08 IL10 IL1B IL4 IL6 TNF
47 negative regulation of apoptotic process GO:0043066 10.07 IL10 IL4 IL6 SOD1 VEGFA

Molecular functions related to Eales Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL10 IL4 IL6 VEGFA
2 cytokine activity GO:0005125 9.17 IFNG IL10 IL1B IL4 IL6 TNF

Sources for Eales Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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