MCID: ELS001
MIFTS: 46

Eales Disease

Categories: Cardiovascular diseases, Eye diseases, Rare diseases

Aliases & Classifications for Eales Disease

MalaCards integrated aliases for Eales Disease:

Name: Eales Disease 20 58 54 70
Idiopathic Recurrent Vitreal Hemorrhage 20
Idiopathic Obliterative Vasculopathy 20
Idiopathic Retinal Perivasculitis 58
Idiopathic Retinal Vasculitis 58

Characteristics:

Orphanet epidemiological data:

58
eales disease
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

MESH via Orphanet 45 C538011
ICD10 via Orphanet 33 H35.0
UMLS via Orphanet 71 C0271073
Orphanet 58 ORPHA40923
UMLS 70 C0271073

Summaries for Eales Disease

GARD : 20 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. This condition is most common among young males and normally affects both eyes. In most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. Treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. Visual prognosis is good if treatment begins early in the course of the disease.

MalaCards based summary : Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to retinal vasculitis and retinal ischemia. An important gene associated with Eales Disease is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Related Diseases for Eales Disease

Diseases related to Eales Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 714)
# Related Disease Score Top Affiliating Genes
1 retinal vasculitis 31.3 TNF SOD1 SAG RBP3 NOS2
2 retinal ischemia 30.4 VEGFA TNF SOD1
3 mycobacterium tuberculosis 1 30.2 TNF IL4 IL10 IFNG
4 retinal artery occlusion 30.2 VEGFA IL6 IL10
5 hand, foot and mouth disease 30.1 IL6 IL10 IFNG
6 myelitis 30.1 TNF IL6 IL10
7 microvascular complications of diabetes 5 30.1 VEGFA SERPINF1 NOS2
8 retinal detachment 30.0 VEGFA TNF SERPINF1 IL6 IL10 IFNG
9 pericarditis 29.9 TNF IL6 IL1B IFNG
10 meningoencephalitis 29.9 TNF IL6 IL1B IL10
11 myositis 29.9 TNF IL6 IL1B IFNG
12 macular holes 29.8 VEGFA SERPINF1 RBP3 IL6
13 pulmonary tuberculosis 29.7 TNF IL6 IL4 IL10 IFNG CP
14 allergic disease 29.7 TNF IL6 IL4 IL1B IL10 IFNG
15 retinal vascular occlusion 29.7 VEGFA SERPINF1 IL6
16 microvascular complications of diabetes 1 29.6 VEGFA TNF SERPINF1 IL6 IL1B
17 central retinal vein occlusion 29.6 VEGFA SERPINF1 IL6
18 optic nerve disease 29.6 VEGFA TNF IL6 IL1B
19 macular retinal edema 29.5 VEGFA TNF SERPINF1 IL6 IL1B
20 optic neuritis 29.5 VEGFA TNF IL6 IL1B IL10
21 retinal vascular disease 29.5 VEGFA TNF SERPINF1 IL6 IL1B
22 encephalitis 29.5 TNF NOS2 IL6 IL1B IL10
23 retinal vein occlusion 29.3 VEGFA TNF SERPINF1 IL6 IL1B
24 thyroiditis 29.3 TNF IL6 IL4 IL1B IL10 IFNG
25 ulcerative colitis 29.3 TNF IL6 IL4 IL1B IL10 IFNG
26 proteasome-associated autoinflammatory syndrome 1 29.2 TNF NOS2 IL6 IL4 IL1B IL10
27 choroiditis 29.2 VEGFA TNF SAG RBP3 IL10 IFNG
28 myocarditis 29.0 TNF NOS2 IL6 IL4 IL1B IL10
29 hypopyon 29.0 VEGFA TNF RBP3 IL6 IL1B IL10
30 vascular disease 29.0 VEGFA TNF SOD1 NOS2 IL6 IL10
31 neuritis 29.0 VEGFA TNF IL6 IL4 IL1B IL10
32 cataract 28.9 VEGFA TNF SOD1 SERPINF1 IL6 CP
33 connective tissue disease 28.9 VEGFA TNF IL6 IL4 IL1B IL10
34 peripheral nervous system disease 28.7 VEGFA TNF SOD1 IL6 IL4 IL1B
35 uveitis 28.6 TNF SERPINF1 SAG RBP3 IL6 IL4
36 chorioretinitis 28.5 VEGFA TNF SAG RBP3 IL6 IL1B
37 macular degeneration, age-related, 1 28.5 VEGFA TNF SERPINF1 SAG RBP3 IL6
38 irvan syndrome 11.6
39 aneurysm 10.8
40 vasculitis 10.7
41 punctate inner choroidopathy 10.4 TNF IL10
42 autoimmune myocarditis 10.4 TNF IFNG
43 meningitis and encephalitis 10.4 SOD1 CP
44 polyarticular juvenile idiopathic arthritis 10.4 TNF IFNG
45 multifocal choroiditis 10.4 TNF IL10
46 panophthalmitis 10.3 SAG IFNG
47 chronic graft versus host disease 10.3 IL10 IFNG
48 skeletal tuberculosis 10.3 TNF IFNG
49 pericardial tuberculosis 10.3 IL10 IFNG
50 chronic beryllium disease 10.3 TNF IFNG

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to Eales Disease

Symptoms & Phenotypes for Eales Disease

MGI Mouse Phenotypes related to Eales Disease:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.31 CP IFNG IL10 IL1B IL6 NOS2
2 homeostasis/metabolism MP:0005376 10.31 CP IFNG IL10 IL1B IL4 IL6
3 hematopoietic system MP:0005397 10.29 CP IFNG IL10 IL1B IL4 IL6
4 growth/size/body region MP:0005378 10.26 IFNG IL10 IL1B IL4 IL6 NOS2
5 immune system MP:0005387 10.26 CP IFNG IL10 IL1B IL4 IL6
6 endocrine/exocrine gland MP:0005379 10.19 IFNG IL10 IL4 IL6 NOS2 SERPINF1
7 nervous system MP:0003631 10.17 CP IFNG IL10 IL1B IL4 IL6
8 integument MP:0010771 10.16 IFNG IL10 IL1B IL4 IL6 NOS2
9 digestive/alimentary MP:0005381 10.15 IFNG IL10 IL4 IL6 NOS2 SERPINF1
10 craniofacial MP:0005382 10.1 IFNG IL10 IL1B IL4 NOS2 TNF
11 liver/biliary system MP:0005370 10.09 CP IFNG IL10 IL4 IL6 NOS2
12 neoplasm MP:0002006 9.97 IFNG IL10 IL1B IL6 NOS2 SOD1
13 muscle MP:0005369 9.95 IFNG IL10 IL6 NOS2 SOD1 TNF
14 reproductive system MP:0005389 9.91 IFNG IL10 IL4 IL6 NOS2 SERPINF1
15 respiratory system MP:0005388 9.7 IFNG IL10 IL4 IL6 NOS2 TNF
16 skeleton MP:0005390 9.7 IFNG IL10 IL1B IL4 IL6 NOS2
17 vision/eye MP:0005391 9.44 CP IFNG IL10 IL4 IL6 NOS2

Drugs & Therapeutics for Eales Disease

Drugs for Eales Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of a VEGF Inhibitor (Lucentis) in Refractory Macular Edema Due to Eales' Disease Completed NCT00384449 Phase 2, Phase 3 Ranibizumab

Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

Anatomical Context for Eales Disease

MalaCards organs/tissues related to Eales Disease:

40
Eye, Retina, Bone, Skin, Heart, Liver, Lung

Publications for Eales Disease

Articles related to Eales Disease:

(show top 50) (show all 393)
# Title Authors PMID Year
1
Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease. 54 61
15283219 2004
2
Eales' disease: increased oxidation and peroxidation products of membrane constituents chiefly lipids and decreased antioxidant enzymes and reduced glutathione in vitreous. 61 54
10487964 1999
3
Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients. 61 54
9873227 1999
4
Further evidence of the association of latent Mycobacterium tuberculosis in Eales' disease. 61
33200391 2021
5
Intravitreal Aflibercept as a Rescue Therapy for Retinal Neovascularization and Macular Edema due to Eales Disease. 61
33628552 2021
6
Comparison of fundus fluorescein angiography, optical coherence tomography and optical coherence tomography angiography features of macular changes in Eales disease: a case series. 61
33314007 2020
7
Is There a True Neuroretinitis in Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) Syndrome ? 61
33331800 2020
8
[Treatment of ocular tuberculosis-an update]. 61
32296921 2020
9
Role of Ultra-widefield Imaging in Eales' Disease: A Case Series. 61
32463328 2020
10
Mycophenolate sodium in the treatment of corticosteroid-refractory non-infectious inflammatory uveitis (MySTRI study). 61
32632297 2020
11
Multimodal imaging in IRVAN syndrome presenting with Branch Retinal Artery Occlusion. 61
33092394 2020
12
Ultrasound findings in a case of Eales' disease and ocular trauma with anterior chamber cholesterolosis. 61
33023541 2020
13
Optical Coherence Tomography Angiography in idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) syndrome: A case report. 61
32933314 2020
14
Extensive Dynamics of Aneurysms and Long-term Prognosis in IRVAN Syndrome: A Case Series. 61
32990491 2020
15
Papillophlebitis as an initial presentation of Eales' disease. 61
33542608 2020
16
Letter to the Editor: Reply to Manuscript "Role of Ultra-widefield Imaging in Eales' Disease: A Case Series". 61
32966156 2020
17
Young Male with Paraparesis and Vision Loss- A Rare Presentation of Eales' Disease. 61
33223685 2020
18
Efficacy of Intravitreal Aflibercept Injections in the Treatment of Idiopathic Retinal Vasculitis, Aneurysms and Neuroretinitis Syndrome. 61
32541433 2020
19
Choroidal Tuberculoma Manifesting in A Patient of Eales Disease 6 Years after Initial Presentation. 61
30339475 2020
20
TREATMENT OF IDIOPATHIC RETINAL VASCULITIS, ANEURYSMS, AND NEURORETINITIS (IRVAN) WITH PHOTOCOAGULATION IN COMBINATION WITH SYSTEMIC IMMUNOSUPPRESSION. 61
29261555 2020
21
Bilateral Congenital Prepapillary Retinal Arterial Loop. 61
33012926 2020
22
Diagnosis of Eales disease from a macular epiretinal membrane. 61
31331646 2019
23
The fluorescein angiographic photodiagnosis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: Outcome of combined therapy. 61
31260747 2019
24
A new perspective for analyzing clinical characteristics of idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome. 61
29934930 2019
25
Resolution of arterial aneurysms in idiopathic retinal vasculitis, aneurysms and neuroretinitis: a case report and review of literature. 61
29594790 2019
26
Idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN): case series of three patients with multimodal imaging. 61
30877369 2019
27
Wide-field angiography for diagnosis and follow-up of Eales disease: a case series. 61
31116318 2019
28
Long-Term Course in Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis. 61
31014692 2019
29
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) in a Patient Without IRVAN History. 61
30419083 2019
30
[IDIOPATHIC RETINAL VASCULITIS - THE INTERPLAY BETWEEN A CHRONIC IDIOPATHIC OCULAR DISEASE, ITS THERAPY AND THE PATIENT]. 61
30779487 2019
31
Evolution of a severe case of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) during pregnancy. 61
30389182 2018
32
Long-term outcomes in a series of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome. 61
30340706 2018
33
Progression of Eales' disease post-partum and long-term follow-up: a case report. 61
30326970 2018
34
Retinal vasculitis and Eales disease. 61
29599058 2018
35
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis Syndrome. 61
31047229 2018
36
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis. 61
30038179 2018
37
Ultra-widefield angiography in the diagnosis and management of uveitis. 61
30294529 2018
38
Pediatric Eales Disease: An Indian Tertiary Eye Center Experience. 61
29709043 2018
39
Pathogenesis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) or 'idiopathic retinal arteriolar aneurysms (IRAA)' with macular star. 61
29447942 2018
40
Spectral domain optical coherence tomography evaluation of macular changes in Eales disease. 61
29480258 2018
41
Multimodal imaging questions etiology of idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome (IRVAN syndrome). 61
29406987 2018
42
Outcomes of transconjunctival sutureless 27-gauge vitrectomy for vitreoretinal diseases. 61
29600174 2018
43
Adaptive Optics Imaging in Retinal Vasculitis. 61
28010147 2018
44
Long-Term Outcomes of a Large Cohort of Patients with Eales' Disease. 61
28448727 2018
45
Role of high-resolution computerized tomography chest in identifying tubercular etiology in patients diagnosed as Eales' disease. 61
28101723 2017
46
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis Syndrome Presenting With Branch Retinal Artery Occlusion. 61
29121367 2017
47
Widefield OCT Angiography of Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis. 61
31047460 2017
48
Eales disease in a young adult man Case report. 61
29516052 2017
49
Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. 61
28724375 2017
50
Unilateral Eales' disease a case report. 61
29450389 2017

Variations for Eales Disease

Expression for Eales Disease

Search GEO for disease gene expression data for Eales Disease.

Pathways for Eales Disease

Pathways related to Eales Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 TNF SERPINF1 NOS2 IL6 IL4 IL1B
2
Show member pathways
13.52 VEGFA TNF IL6 IL4 IL1B IL10
3
Show member pathways
13.38 VEGFA TNF NOS2 IL6 IL4 IL1B
4
Show member pathways
13.2 TNF NOS2 IL6 IL1B IL10 IFNG
5
Show member pathways
12.9 VEGFA TNF IL6 IL4 IL1B IL10
6 12.85 VEGFA NOS2 IL6 IL4 IFNG
7
Show member pathways
12.67 TNF IL6 IL4 IL1B IL10 IFNG
8
Show member pathways
12.66 TNF IL6 IL4 IL1B IL10 IFNG
9
Show member pathways
12.64 TNF NOS2 IL6 IL1B IL10 IFNG
10 12.61 TNF IL4 IL1B IL10 IFNG
11
Show member pathways
12.43 IL6 IL4 IL10 IFNG
12
Show member pathways
12.4 TNF IL6 IL4 IL1B IFNG
13
Show member pathways
12.4 TNF SOD1 IL6 IL4 IL1B IFNG
14
Show member pathways
12.37 TNF NOS2 IL6 IL1B IFNG
15
Show member pathways
12.32 TNF IL6 IL4 IL1B IL10 IFNG
16
Show member pathways
12.3 TNF NOS2 IL6 IL1B CP
17
Show member pathways
12.3 TNF NOS2 IL4 IL1B IL10 IFNG
18 12.27 VEGFA TNF NOS2 IL6 IFNG
19 12.26 TNF NOS2 IL6 IL1B IL10 IFNG
20
Show member pathways
12.25 TNF IL6 IL1B IL10
21
Show member pathways
12.19 TNF NOS2 IL6 IL4 IL1B IFNG
22 12.16 VEGFA TNF TF IL6 IL1B IL10
23 12.14 VEGFA TNF IL1B IFNG
24 12.14 TNF IL6 IL1B IL10
25 12.08 TNF IL6 IL4 IL10 IFNG
26
Show member pathways
12.04 NOS2 IL4 IL1B IFNG
27 12.03 VEGFA TF NOS2 IL6 IFNG
28 11.99 VEGFA TNF IL6 IL1B
29 11.98 TNF IL6 IL4 IL1B
30 11.97 TNF IL6 IL1B
31 11.96 VEGFA TNF IL6 IL1B IFNG
32 11.96 TNF NOS2 IL6 IL4 IL1B IFNG
33 11.94 IL6 IL1B IFNG
34
Show member pathways
11.94 IL6 IL4 IL1B IFNG
35 11.88 TNF IL4 IL1B IL10 IFNG
36
Show member pathways
11.85 TNF IL6 IL1B IL10 IFNG
37 11.84 TNF NOS2 IL6 IL1B IL10
38 11.83 IL6 IL4 IFNG
39 11.81 TNF NOS2 IL6 IL1B IL10 IFNG
40 11.8 TNF IL6 IL1B IL10 IFNG
41
Show member pathways
11.79 TNF IL4 IFNG
42 11.78 VEGFA TF NOS2 CP
43 11.76 TNF IL6 IL4 IL1B
44 11.73 TNF NOS2 IL6 IL4 IL10
45
Show member pathways
11.67 SOD1 NOS2 CP
46 11.65 TNF IL6 IL1B
47 11.64 NOS2 IL6 IFNG
48 11.61 TNF NOS2 IL1B IFNG
49 11.6 TNF IL6 IFNG
50 11.6 VEGFA NOS2 IL6

GO Terms for Eales Disease

Cellular components related to Eales Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VEGFA TNF TF SOD1 SERPINF1 RBP3
2 extracellular space GO:0005615 9.4 VEGFA TNF TF SOD1 SERPINF1 RBP3

Biological processes related to Eales Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.1 VEGFA IL6 IL4 IL1B IFNG
2 negative regulation of apoptotic process GO:0043066 10.1 VEGFA SOD1 IL6 IL4 IL10
3 positive regulation of transcription, DNA-templated GO:0045893 10.1 TNF TF IL6 IL4 IL1B IL10
4 positive regulation of gene expression GO:0010628 10.03 VEGFA TNF IL6 IL4 IL1B IFNG
5 immune response GO:0006955 10.01 TNF IL6 IL4 IL1B IL10 IFNG
6 positive regulation of protein phosphorylation GO:0001934 9.98 VEGFA TNF IL1B IFNG
7 negative regulation of gene expression GO:0010629 9.98 VEGFA TNF SERPINF1 NOS2 IFNG
8 negative regulation of inflammatory response GO:0050728 9.91 SOD1 SERPINF1 IL4 IL10
9 positive regulation of inflammatory response GO:0050729 9.89 TNF IL1B IFNG
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.89 VEGFA TNF IL6
11 response to organic substance GO:0010033 9.89 TNF SOD1 IL10
12 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL10
13 positive regulation of T cell proliferation GO:0042102 9.87 IL6 IL4 IL1B
14 positive regulation of DNA-binding transcription factor activity GO:0051091 9.87 TNF IL6 IL1B IL10
15 cellular iron ion homeostasis GO:0006879 9.86 TF SOD1 CP
16 positive regulation of interleukin-8 production GO:0032757 9.86 TNF IL6 IL1B
17 humoral immune response GO:0006959 9.85 TNF IL6 IFNG
18 positive regulation of interleukin-1 beta production GO:0032731 9.85 TNF IL6 IFNG
19 positive regulation of interleukin-6 production GO:0032755 9.85 TNF IL6 IL1B IFNG
20 positive regulation of protein complex assembly GO:0031334 9.83 VEGFA TNF IFNG
21 cellular response to lipopolysaccharide GO:0071222 9.83 TNF NOS2 IL6 IL1B IL10
22 interleukin-12-mediated signaling pathway GO:0035722 9.82 SOD1 IL10 IFNG
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 TNF IL1B IFNG
24 positive regulation of chemokine production GO:0032722 9.8 TNF IL6 IFNG
25 positive regulation of JAK-STAT cascade GO:0046427 9.79 TNF IL6 IL10
26 microglial cell activation GO:0001774 9.78 TNF IL4 IFNG
27 negative regulation of neurogenesis GO:0050768 9.75 TNF IL6 IL1B
28 astrocyte activation GO:0048143 9.72 TNF IFNG
29 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.72 TNF IL6
30 positive regulation of signaling receptor activity GO:2000273 9.72 IL10 IFNG
31 negative regulation of amyloid-beta clearance GO:1900222 9.72 TNF IFNG
32 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
33 negative regulation of lipid storage GO:0010888 9.71 TNF IL6
34 endothelial cell apoptotic process GO:0072577 9.71 TNF IL10
35 positive regulation of cytokine production GO:0001819 9.71 TNF SOD1 IL10 IFNG
36 positive regulation of glial cell proliferation GO:0060252 9.7 TNF IL6 IL1B
37 positive regulation of mononuclear cell migration GO:0071677 9.69 TNF IL4
38 positive regulation of killing of cells of other organism GO:0051712 9.69 NOS2 IFNG
39 negative regulation of cytokine production involved in immune response GO:0002719 9.69 TNF IL10
40 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 TNF IL1B IFNG
41 positive regulation of cellular respiration GO:1901857 9.67 IL4 IFNG
42 neuroinflammatory response GO:0150076 9.67 IL4 IFNG
43 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 TNF IL1B IL10
44 positive regulation of phagocytosis GO:0050766 9.67 TNF SOD1 IL1B IFNG
45 type 2 immune response GO:0042092 9.66 IL4 IL10
46 positive regulation of fever generation GO:0031622 9.66 TNF IL1B
47 sequestering of triglyceride GO:0030730 9.65 TNF IL1B
48 positive regulation of neuroinflammatory response GO:0150078 9.65 TNF IL6 IL1B
49 regulation of isotype switching GO:0045191 9.64 IL4 IL10
50 response to carbon monoxide GO:0034465 9.63 SOD1 IL10

Molecular functions related to Eales Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 VEGFA IL6 IL4 IL10
2 cytokine activity GO:0005125 9.17 VEGFA TNF IL6 IL4 IL1B IL10

Sources for Eales Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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