MCID: ELS001
MIFTS: 45

Eales Disease

Categories: Cardiovascular diseases, Eye diseases, Rare diseases

Aliases & Classifications for Eales Disease

MalaCards integrated aliases for Eales Disease:

Name: Eales Disease 52 58 54 71
Idiopathic Recurrent Vitreal Hemorrhage 52
Idiopathic Obliterative Vasculopathy 52
Idiopathic Retinal Perivasculitis 58
Idiopathic Retinal Vasculitis 58

Characteristics:

Orphanet epidemiological data:

58
eales disease
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

MESH via Orphanet 44 C538011
ICD10 via Orphanet 33 H35.0
UMLS via Orphanet 72 C0271073
Orphanet 58 ORPHA40923
UMLS 71 C0271073

Summaries for Eales Disease

NIH Rare Diseases : 52 Eales disease is a rare vision disorder that appears as an inflammation and white haze around the outercoat of the veins in the retina. This condition is most common among young males and normally affects both eyes. In most cases, vision becomes suddenly blurred because the vitreous, the clear jelly that fills the eyeball behind the lens of the eye, seeps out. Treatment includes corticosteroids in the inflammation stage and photocoagulation in the proliferative stage of the disease. Visual prognosis is good if treatment begins early in the course of the disease.

MalaCards based summary : Eales Disease, also known as idiopathic recurrent vitreal hemorrhage, is related to retinal vasculitis and allergic hypersensitivity disease. An important gene associated with Eales Disease is SOD1 (Superoxide Dismutase 1), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and t cells, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 74 Eales disease is a type of obliterative vasculopathy, also known as angiopathia retinae juvenilis,... more...

Related Diseases for Eales Disease

Diseases related to Eales Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 684)
# Related Disease Score Top Affiliating Genes
1 retinal vasculitis 32.6 TNF SAG RBP3
2 allergic hypersensitivity disease 30.3 TNF IL4 IL10 IFNG
3 myelitis 30.2 TNF IL6 IL10
4 retinal ischemia 30.2 VEGFA TNF SOD1 IL1B
5 hand, foot and mouth disease 30.1 IL6 IL10 IFNG
6 mycobacterium tuberculosis 1 30.1 TNF IL4 IL10 IFNG
7 retinal artery occlusion 30.0 VEGFA IL6 IL10
8 microvascular complications of diabetes 5 29.9 VEGFA SOD1 SERPINF1 NOS2
9 thyroiditis 29.8 TNF IL6 IL4 IL10
10 pericarditis 29.8 TNF IL6 IL1B IFNG
11 myositis 29.7 TNF IL6 IL1B IFNG
12 migraine with or without aura 1 29.7 TNF IL6 IL1B IL10
13 retinal detachment 29.7 VEGFA TNF SERPINF1 IL6 IL10 IFNG
14 stroke, ischemic 29.6 VEGFA TNF IL6 IL1B
15 central retinal vein occlusion 29.5 VEGFA SERPINF1 IL6
16 optic nerve disease 29.5 VEGFA TNF IL6 IL1B
17 retinal vascular occlusion 29.4 VEGFA SERPINF1 IL6
18 meningoencephalitis 29.4 TNF IL6 IL4 IL1B IL10
19 retinal vascular disease 29.2 VEGFA TNF SERPINF1 IL6 IL1B
20 optic neuritis 29.2 VEGFA TNF IL6 IL1B IL10
21 choroiditis 29.1 VEGFA TNF SAG RBP3 IL10 IFNG
22 ulcerative colitis 29.1 TNF IL6 IL4 IL1B IL10 IFNG
23 macular retinal edema 29.1 VEGFA TNF SERPINF1 IL6 IL1B
24 neuritis 29.1 TNF IL6 IL4 IL1B IL10 IFNG
25 retinal vein occlusion 29.1 VEGFA TNF SERPINF1 IL6 IL1B
26 hypopyon 29.1 VEGFA TNF RBP3 IL6 IL10
27 pulmonary tuberculosis 29.0 TNF IL6 IL4 IL1B IL10 IFNG
28 encephalitis 28.9 TNF NOS2 IL6 IL4 IL1B IL10
29 proteasome-associated autoinflammatory syndrome 1 28.9 TNF NOS2 IL6 IL4 IL1B IL10
30 vascular disease 28.7 VEGFA TNF SOD1 NOS2 IL6 IL10
31 multiple sclerosis 28.6 TNF SAG NOS2 IL6 IL4 IL1B
32 colitis 28.6 TNF NOS2 IL6 IL4 IL1B IL10
33 myocarditis 28.6 TNF NOS2 IL6 IL4 IL1B IL10
34 connective tissue disease 28.5 VEGFA TNF IL6 IL4 IL1B IL10
35 cataract 28.5 VEGFA TNF SOD1 SERPINF1 IL6 CP
36 chorioretinitis 28.5 VEGFA TNF SAG RBP3 IL6 IL10
37 peripheral nervous system disease 28.3 VEGFA TNF SOD1 IL6 IL4 IL1B
38 macular degeneration, age-related, 1 28.1 VEGFA TNF SERPINF1 SAG RBP3 IL6
39 uveitis 28.0 TNF SERPINF1 SAG RBP3 IL6 IL4
40 irvan syndrome 12.3
41 aneurysm 10.8
42 vasculitis 10.7
43 punctate inner choroidopathy 10.5 TNF IL10
44 autoimmune myocarditis 10.5 TNF IFNG
45 meningitis and encephalitis 10.5 SOD1 CP
46 multifocal choroiditis 10.5 TNF IL10
47 polyarticular juvenile idiopathic arthritis 10.5 TNF IFNG
48 physiological polycythemia 10.4 TNF IL1B
49 chronic graft versus host disease 10.4 IL10 IFNG
50 chronic beryllium disease 10.4 TNF IFNG

Graphical network of the top 20 diseases related to Eales Disease:



Diseases related to Eales Disease

Symptoms & Phenotypes for Eales Disease

MGI Mouse Phenotypes related to Eales Disease:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.29 CP IFNG IL10 IL1B IL4 IL6
2 cardiovascular system MP:0005385 10.27 CP IFNG IL10 IL1B IL6 NOS2
3 homeostasis/metabolism MP:0005376 10.27 CP IFNG IL10 IL1B IL4 IL6
4 immune system MP:0005387 10.26 CP IFNG IL10 IL1B IL4 IL6
5 growth/size/body region MP:0005378 10.22 IFNG IL10 IL1B IL4 IL6 NOS2
6 endocrine/exocrine gland MP:0005379 10.19 IFNG IL10 IL4 IL6 NOS2 SERPINF1
7 digestive/alimentary MP:0005381 10.15 IFNG IL10 IL4 IL6 NOS2 SERPINF1
8 nervous system MP:0003631 10.13 CP IFNG IL10 IL1B IL4 IL6
9 integument MP:0010771 10.11 IFNG IL10 IL1B IL4 IL6 NOS2
10 craniofacial MP:0005382 10.1 IFNG IL10 IL1B IL4 NOS2 TNF
11 liver/biliary system MP:0005370 10.09 CP IFNG IL10 IL4 IL6 NOS2
12 neoplasm MP:0002006 9.97 IFNG IL10 IL1B IL6 NOS2 SOD1
13 muscle MP:0005369 9.95 IFNG IL10 IL6 NOS2 SOD1 TNF
14 reproductive system MP:0005389 9.91 IFNG IL10 IL4 IL6 NOS2 SERPINF1
15 respiratory system MP:0005388 9.7 IFNG IL10 IL4 IL6 NOS2 TNF
16 skeleton MP:0005390 9.65 IFNG IL10 IL1B IL4 IL6 NOS2
17 vision/eye MP:0005391 9.4 CP IFNG IL10 IL4 IL6 NOS2

Drugs & Therapeutics for Eales Disease

Drugs for Eales Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of a VEGF Inhibitor (Lucentis) in Refractory Macular Edema Due to Eales' Disease Completed NCT00384449 Phase 2, Phase 3 Ranibizumab
2 Treatment of the Bilateral Severe Uveitis by IVT of Regulator T-cells: Study of Tolerance of Dose Suspended NCT02494492 Phase 1, Phase 2

Search NIH Clinical Center for Eales Disease

Genetic Tests for Eales Disease

Anatomical Context for Eales Disease

MalaCards organs/tissues related to Eales Disease:

40
Eye, Retina, T Cells, Endothelial, Testes, Monocytes, Brain

Publications for Eales Disease

Articles related to Eales Disease:

(show top 50) (show all 380)
# Title Authors PMID Year
1
Determination of carbonyl group content in plasma proteins as a useful marker to assess impairment in antioxidant defense in patients with Eales' disease. 61 54
15283219 2004
2
Eales' disease: increased oxidation and peroxidation products of membrane constituents chiefly lipids and decreased antioxidant enzymes and reduced glutathione in vitreous. 54 61
10487964 1999
3
Cellular immune response to retinal S-antigen and interphotoreceptor retinoid-binding protein fragments in Eales' disease patients. 61 54
9873227 1999
4
Efficacy of Intravitreal Aflibercept Injections in the Treatment of Idiopathic Retinal Vasculitis, Aneurysms and Neuroretinitis Syndrome. 61
32541433 2020
5
Role of Ultra-widefield Imaging in Eales' Disease: A Case Series. 61
32463328 2020
6
[Treatment of ocular tuberculosis-an update]. 61
32296921 2020
7
Choroidal Tuberculoma Manifesting in A Patient of Eales Disease 6 Years after Initial Presentation. 61
30339475 2020
8
Diagnosis of Eales disease from a macular epiretinal membrane. 61
31331646 2019
9
The fluorescein angiographic photodiagnosis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: Outcome of combined therapy. 61
31260747 2019
10
A new perspective for analyzing clinical characteristics of idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome. 61
29934930 2019
11
Idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN): case series of three patients with multimodal imaging. 61
30877369 2019
12
Resolution of arterial aneurysms in idiopathic retinal vasculitis, aneurysms and neuroretinitis: a case report and review of literature. 61
29594790 2019
13
Wide-field angiography for diagnosis and follow-up of Eales disease: a case series. 61
31116318 2019
14
Long-Term Course in Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis. 61
31014692 2019
15
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) in a Patient Without IRVAN History. 61
30419083 2019
16
[IDIOPATHIC RETINAL VASCULITIS - THE INTERPLAY BETWEEN A CHRONIC IDIOPATHIC OCULAR DISEASE, ITS THERAPY AND THE PATIENT]. 61
30779487 2019
17
Evolution of a severe case of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) during pregnancy. 61
30389182 2018
18
Long-term outcomes in a series of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome. 61
30340706 2018
19
Retinal vasculitis and Eales disease. 61
29599058 2018
20
Progression of Eales' disease post-partum and long-term follow-up: a case report. 61
30326970 2018
21
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis Syndrome. 61
31047229 2018
22
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis. 61
30038179 2018
23
Pediatric Eales Disease: An Indian Tertiary Eye Center Experience. 61
29709043 2018
24
Ultra-widefield angiography in the diagnosis and management of uveitis. 61
30294529 2018
25
Pathogenesis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) or 'idiopathic retinal arteriolar aneurysms (IRAA)' with macular star. 61
29447942 2018
26
Spectral domain optical coherence tomography evaluation of macular changes in Eales disease. 61
29480258 2018
27
Multimodal imaging questions etiology of idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome (IRVAN syndrome). 61
29406987 2018
28
Outcomes of transconjunctival sutureless 27-gauge vitrectomy for vitreoretinal diseases. 61
29600174 2018
29
Adaptive Optics Imaging in Retinal Vasculitis. 61
28010147 2018
30
Long-Term Outcomes of a Large Cohort of Patients with Eales' Disease. 61
28448727 2018
31
TREATMENT OF IDIOPATHIC RETINAL VASCULITIS, ANEURYSMS, AND NEURORETINITIS (IRVAN) WITH PHOTOCOAGULATION IN COMBINATION WITH SYSTEMIC IMMUNOSUPPRESSION. 61
29261555 2017
32
Role of high-resolution computerized tomography chest in identifying tubercular etiology in patients diagnosed as Eales' disease. 61
28101723 2017
33
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis Syndrome Presenting With Branch Retinal Artery Occlusion. 61
29121367 2017
34
Widefield OCT Angiography of Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis. 61
31047460 2017
35
Eales disease in a young adult man Case report. 61
29516052 2017
36
Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. 61
28724375 2017
37
Unilateral Eales' disease a case report. 61
29450389 2017
38
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both? 61
26842710 2017
39
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: clinical perspectives. 61
29062224 2017
40
A rare presentation of exudative macroaneurysms in unilateral Eales' disease. 61
29022965 2017
41
The 88-kDa Eales' protein in serum is a complex of haptoglobin, complement C3, and galectin-1 as identified by liquid chromatography coupled mass spectrometry. 61
27739660 2017
42
Localization of Human Copper Transporter 1 in the Eye and its Role in Eales Disease. 61
26807780 2016
43
Fluorescein photodiagnosis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: A case report and long-term outcome of photocoagulation therapy. 61
27491854 2016
44
Vanishing retinal arterial aneurysms with anti-tubercular treatment in a patient presenting with idiopathic retinal vasculitis, aneurysms, and neuroretinitis. 61
26922651 2016
45
Eales Disease. 61
28586583 2016
46
VISUAL OUTCOME AND POOR PROGNOSTIC FACTORS IN ISOLATED IDIOPATHIC RETINAL VASCULITIS. 61
26991648 2016
47
Management of postvitrectomy retinal detachment due to multiple laser-induced retinal holes. 61
27664228 2016
48
Ultra-wide field angiography in the management of Eales disease. 61
27609162 2016
49
Idiopathic retinal vasculitis, aneurysms and neuroretinitis case report. 61
29503895 2016
50
Detection of Mycobacterium tuberculosis with nested polymerase chain reaction analysis in enucleated eye ball in Eales' disease. 61
26499903 2016

Variations for Eales Disease

Expression for Eales Disease

Search GEO for disease gene expression data for Eales Disease.

Pathways for Eales Disease

Pathways related to Eales Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 TNF SERPINF1 NOS2 IL6 IL4 IL1B
2
Show member pathways
13.52 VEGFA TNF IL6 IL4 IL1B IL10
3
Show member pathways
13.38 VEGFA TNF NOS2 IL6 IL4 IL1B
4
Show member pathways
13.07 TNF NOS2 IL6 IL1B IL10 IFNG
5
Show member pathways
12.89 VEGFA TNF IL6 IL4 IL1B IL10
6 12.85 VEGFA NOS2 IL6 IL4 IFNG
7
Show member pathways
12.74 TNF NOS2 IL6 IL1B CP
8
Show member pathways
12.66 TNF IL6 IL4 IL1B IL10 IFNG
9
Show member pathways
12.65 TNF IL6 IL4 IL1B IL10 IFNG
10
Show member pathways
12.64 TNF NOS2 IL6 IL1B IL10 IFNG
11 12.6 TNF IL4 IL1B IL10 IFNG
12
Show member pathways
12.44 IL6 IL4 IL10 IFNG
13
Show member pathways
12.39 TNF IL6 IL4 IL1B IFNG
14
Show member pathways
12.38 TNF SOD1 IL6 IL4 IL1B IFNG
15
Show member pathways
12.37 TNF NOS2 IL6 IL1B IFNG
16
Show member pathways
12.32 TNF IL6 IL4 IL1B IL10 IFNG
17
Show member pathways
12.29 TNF NOS2 IL4 IL1B IL10 IFNG
18 12.26 VEGFA TNF NOS2 IL6 IFNG
19
Show member pathways
12.25 TNF IL6 IL1B IL10
20 12.24 TNF NOS2 IL6 IL1B IL10 IFNG
21
Show member pathways
12.19 TNF NOS2 IL6 IL4 IL1B IFNG
22 12.16 VEGFA TNF TF IL6 IL1B IL10
23 12.14 VEGFA TNF IL1B IFNG
24 12.07 TNF IL6 IL1B IL10
25 12.07 TNF IL6 IL4 IL10 IFNG
26
Show member pathways
12.04 NOS2 IL4 IL1B IFNG
27 12.03 VEGFA TF NOS2 IL6 IFNG
28
Show member pathways
12.01 TNF IL6 IL1B IL10 IFNG
29 11.98 VEGFA TNF IL6 IL1B
30 11.97 TNF IL6 IL4 IL1B
31 11.96 TNF IL6 IL1B
32 11.96 TNF NOS2 IL6 IL4 IL1B IFNG
33 11.94 IL6 IL1B IFNG
34 11.94 VEGFA TNF IL6 IL1B IFNG
35
Show member pathways
11.93 IL6 IL4 IL1B IFNG
36 11.86 TNF IL4 IL1B IL10 IFNG
37 11.83 TNF NOS2 IL6 IL1B IL10
38 11.82 IL6 IL4 IFNG
39 11.81 TNF NOS2 IL6 IL1B IL10 IFNG
40
Show member pathways
11.79 TNF IL4 IFNG
41 11.79 TNF IL6 IL1B IL10 IFNG
42 11.77 VEGFA TF NOS2 CP
43 11.75 TNF IL6 IL4 IL1B
44
Show member pathways
11.67 SOD1 NOS2 CP
45 11.66 TNF IL6 IL1B
46 11.64 NOS2 IL6 IFNG
47 11.6 TNF IL6 IFNG
48 11.6 VEGFA NOS2 IL6
49 11.6 TNF NOS2 IL1B IFNG
50 11.57 VEGFA TF IL6

GO Terms for Eales Disease

Cellular components related to Eales Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VEGFA TNF TF SOD1 SERPINF1 RBP3
2 cell GO:0005623 9.63 TF SOD1 SERPINF1 NOS2 IL6 CP
3 secretory granule GO:0030141 9.43 VEGFA SOD1 IL1B
4 extracellular space GO:0005615 9.4 VEGFA TNF TF SOD1 SERPINF1 RBP3

Biological processes related to Eales Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.2 VEGFA TNF IL6 IL4 IL1B IL10
2 positive regulation of cell proliferation GO:0008284 10.1 VEGFA IL6 IL4 IL1B IFNG
3 negative regulation of apoptotic process GO:0043066 10.1 VEGFA SOD1 IL6 IL4 IL10
4 positive regulation of transcription, DNA-templated GO:0045893 10.09 TNF TF IL6 IL4 IL1B IL10
5 immune response GO:0006955 10.01 TNF IL6 IL4 IL1B IL10 IFNG
6 positive regulation of gene expression GO:0010628 10 VEGFA TNF IL6 IL4 IL1B IFNG
7 negative regulation of gene expression GO:0010629 9.97 VEGFA TNF SERPINF1 NOS2 IFNG
8 positive regulation of protein phosphorylation GO:0001934 9.96 VEGFA TNF IL1B IFNG
9 negative regulation of inflammatory response GO:0050728 9.92 SOD1 SERPINF1 IL4 IL10
10 platelet degranulation GO:0002576 9.91 VEGFA TF SOD1
11 positive regulation of inflammatory response GO:0050729 9.9 TNF IL1B IFNG
12 response to organic substance GO:0010033 9.9 TNF SOD1 IL10
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.89 VEGFA TNF IL6
14 response to glucocorticoid GO:0051384 9.88 TNF IL6 IL10
15 positive regulation of T cell proliferation GO:0042102 9.87 IL6 IL4 IL1B
16 cellular iron ion homeostasis GO:0006879 9.86 TF SOD1 CP
17 humoral immune response GO:0006959 9.86 TNF IL6 IFNG
18 positive regulation of DNA-binding transcription factor activity GO:0051091 9.86 TNF IL6 IL1B IL10
19 positive regulation of interleukin-6 production GO:0032755 9.84 TNF IL6 IL1B
20 positive regulation of protein complex assembly GO:0031334 9.84 VEGFA TNF IFNG
21 interleukin-12-mediated signaling pathway GO:0035722 9.82 SOD1 IL10 IFNG
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 TNF IL1B IFNG
23 positive regulation of interleukin-6 secretion GO:2000778 9.81 TNF IL1B IFNG
24 cellular response to lipopolysaccharide GO:0071222 9.8 TNF NOS2 IL6 IL1B IL10
25 positive regulation of cytokine secretion GO:0050715 9.79 TNF IL10 IFNG
26 positive regulation of JAK-STAT cascade GO:0046427 9.78 TNF IL6 IL10
27 microglial cell activation GO:0001774 9.77 TNF IL4 IFNG
28 regulation of insulin secretion GO:0050796 9.76 TNF NOS2 IL1B IFNG
29 negative regulation of neurogenesis GO:0050768 9.75 TNF IL6 IL1B
30 negative regulation of lipid catabolic process GO:0050995 9.73 TNF IL1B
31 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.73 TNF IL1B
32 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.73 TNF IL6
33 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.72 IL4 IL10
34 negative regulation of amyloid-beta clearance GO:1900222 9.72 TNF IFNG
35 positive regulation of glial cell proliferation GO:0060252 9.72 TNF IL6 IL1B
36 negative regulation of lipid storage GO:0010888 9.71 TNF IL6
37 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.71 TNF IFNG
38 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
39 endothelial cell apoptotic process GO:0072577 9.71 TNF IL10
40 positive regulation of mononuclear cell migration GO:0071677 9.7 TNF IL4
41 positive regulation of killing of cells of other organism GO:0051712 9.69 NOS2 IFNG
42 type 2 immune response GO:0042092 9.69 IL4 IL10
43 negative regulation of cytokine production involved in immune response GO:0002719 9.69 TNF IL10
44 astrocyte activation GO:0048143 9.69 TNF IL1B IFNG
45 positive regulation of cellular respiration GO:1901857 9.68 IL4 IFNG
46 neuroinflammatory response GO:0150076 9.68 IL4 IFNG
47 positive regulation of fever generation GO:0031622 9.67 TNF IL1B
48 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 TNF IL10
49 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 TNF IL1B IFNG
50 regulation of isotype switching GO:0045191 9.65 IL4 IL10

Molecular functions related to Eales Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 VEGFA IL6 IL4 IL10
2 cytokine activity GO:0005125 9.17 VEGFA TNF IL6 IL4 IL1B IL10

Sources for Eales Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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