MCID: ERL002
MIFTS: 32

Early Congenital Syphilis

Categories: Bone diseases, Fetal diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Early Congenital Syphilis

MalaCards integrated aliases for Early Congenital Syphilis:

Name: Early Congenital Syphilis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050488
ICD10 32 A50.2
UMLS 70 C0275859

Summaries for Early Congenital Syphilis

Disease Ontology : 12 A congenital syphilis that is manifested during the first 3 months of life. The infection has symptom skin lesions, has symptom lymphadenopathy, has symptom hepatosplenomegaly, has symptom failure to thrive, has symptom blood-stained nasal discharge, has symptom perioral fissures, has symptom meningitis, has symptom choroiditis, has symptom hydrocephalus, has symptom seizures, has symptom intellectual disability, has symptom osteochondritis, and has symptom pseudoparalysis.

MalaCards based summary : Early Congenital Syphilis is related to congenital syphilis and syphilis, and has symptoms including intellectual disability, seizures and failure to thrive. An important gene associated with Early Congenital Syphilis is POLA1 (DNA Polymerase Alpha 1, Catalytic Subunit), and among its related pathways/superpathways are IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Angiogenesis (WikiPathways). Affiliated tissues include bone, heart and small intestine, and related phenotype is cardiovascular system.

Related Diseases for Early Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Early Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 congenital syphilis 31.8 TPR POLA1
2 syphilis 30.7 TPR POLA1 FOXP3 F2 CRP
3 orchitis 30.1 FOXP3 CRP
4 thrombocytopenia 28.9 FOXP3 F2 ENG CRP ANGPT1
5 latent syphilis 10.3 TPR POLA1
6 exanthem 10.3
7 yaws 10.3 TPR POLA1
8 gummatous syphilis 10.3 TPR CRP
9 bicipital tenosynovitis 10.2 ENG CRP
10 capillary lymphangioma 10.2 ENG CRP
11 pulmonary arterial hypertension associated with congenital heart disease 10.2 ENG CRP
12 rhinitis 10.2
13 mobitz type ii atrioventricular block 10.2 ENG CRP
14 glomeruloid hemangioma 10.1 FLT1 ENG
15 primary syphilis 10.1 TPR POLA1 CRP
16 secondary syphilis 10.1 TPR POLA1 CRP
17 neonatal anemia 10.1 FLT1 ENG
18 tertiary syphilis 10.1 TTPA TPR CRP
19 macrophage activation syndrome 10.1 CRP ANGPT1
20 mild pre-eclampsia 10.1 FLT1 ENG
21 orbital osteomyelitis 10.1 F2 CRP
22 achenbach syndrome 10.1 F2 CRP
23 small intestine diverticulitis 10.1 F2 CRP
24 renal pelvis squamous cell carcinoma 10.1 F2 CRP
25 synovial angioma 10.1 F2 CRP
26 hematocele of tunica vaginalis testis 10.1 F2 CRP
27 emphysematous cholecystitis 10.1 F2 CRP
28 ankylosing spondylitis 1 10.1 F2 CRP
29 funisitis 10.1 CRP ANGPT1
30 cavernous sinus thrombosis 10.1 F2 CRP
31 subdural empyema 10.1 F2 CRP
32 epidural abscess 10.1 F2 CRP
33 blood group, globoside system 10.1 FLT1 CRP
34 lemierre's syndrome 10.1 F2 CRP
35 internal hemorrhoid 10.1 F2 CRP
36 hemorrhoid 10.1 F2 CRP
37 acute cor pulmonale 10.1 F2 CRP
38 acalculous cholecystitis 10.1 F2 CRP
39 intracranial sinus thrombosis 10.1 F2 CRP
40 splenic abscess 10.1 F2 CRP
41 ascending cholangitis 10.1 F2 CRP
42 hemopericardium 10.1 F2 CRP
43 abducens nerve disease 10.1 F2 CRP
44 mediastinitis 10.1 F2 CRP
45 cholesterol embolism 10.1 F2 CRP
46 cauda equina syndrome 10.1 F2 CRP
47 lipodermatosclerosis 10.1 FLT1 ANGPT1
48 splenic tuberculosis 10.1 F2 CRP
49 angiokeratoma circumscriptum 10.1 FLT1 ANGPT1
50 paralytic ileus 10.1 F2 CRP

Graphical network of the top 20 diseases related to Early Congenital Syphilis:



Diseases related to Early Congenital Syphilis

Symptoms & Phenotypes for Early Congenital Syphilis

Symptoms:

12 (show all 13)
  • intellectual disability
  • seizures
  • failure to thrive
  • hydrocephalus
  • meningitis
  • lymphadenopathy
  • hepatosplenomegaly
  • skin lesions
  • blood-stained nasal discharge
  • perioral fissures
  • choroiditis
  • osteochondritis
  • pseudoparalysis

MGI Mouse Phenotypes related to Early Congenital Syphilis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.23 ANGPT1 CRP ENG F2 FLT1 FOXP3

Drugs & Therapeutics for Early Congenital Syphilis

Search Clinical Trials , NIH Clinical Center for Early Congenital Syphilis

Genetic Tests for Early Congenital Syphilis

Anatomical Context for Early Congenital Syphilis

MalaCards organs/tissues related to Early Congenital Syphilis:

40
Bone, Heart, Small Intestine, Placenta, Testis, Skin, Liver

Publications for Early Congenital Syphilis

Articles related to Early Congenital Syphilis:

(show top 50) (show all 119)
# Title Authors PMID Year
1
[Early congenital syphilis, inadequate screening. Case report]. 61
32421271 2020
2
An unusual presentation of early congenital syphilis with annular configuration of blisters resembling "string-of-pearls". 61
31177579 2019
3
Congenital Syphilis and the Prozone Phenomenon: A Case Study. 61
30499825 2018
4
Infectious and congenital syphilis in Canada, 2010-2015. 61
29770098 2018
5
Early Congenital Syphilis: Recognising Symptoms of an Increasingly Prevalent Disease. 61
28821219 2018
6
Skin rash: a manifestation of early congenital syphilis. 61
27268292 2016
7
Syphilis Infection: An Uncommon Etiology of Infectious Nonimmune Fetal Hydrops with Anemia. 61
25138225 2016
8
Symptomatic Early Congenital Syphilis: A Common but Forgotten Disease. 61
26522203 2015
9
Congenital syphilis: The continuing scourge. 61
26396451 2014
10
Early congenital syphilis presenting with vesicobullous eruptions beyond palmoplantar regions. 61
24037177 2014
11
[Early congenital syphilis: a case report]. 61
25079189 2014
12
Varied presentations of early congenital syphilis. 61
23306406 2013
13
Seroreversion of treponemal tests in infants meeting canadian surveillance criteria for confirmed early congenital syphilis. 61
22976052 2013
14
Early congenital syphilis in a premature newborn: typical cutaneous manifestations in atypical skin areas. 61
22331208 2012
15
Picture of the month-quiz case. Early congenital syphilis. 61
22869409 2012
16
Syphilis Infection during pregnancy: fetal risks and clinical management. 61
22829747 2012
17
Symptomatic early congenital syphilis: a common but forgotten disease. 61
23094175 2012
18
Early congenital syphilis presenting with skin eruption alone: a case report. 61
22323908 2011
19
Early congenital syphilis in a premature baby. 61
21107603 2011
20
Congenital syphilis, case report and epidemiologic features in Spain. 61
20609158 2010
21
A systematic review of pediatric sensorineural hearing loss in congenital syphilis. 61
19321207 2009
22
Early congenital syphilis with isolated bone involvement: a case report. 61
19480330 2009
23
[Follow-up of auditory function in children with early congenital syphilis]. 61
19102845 2008
24
[Syphilis and pregnancy]. 61
18006242 2008
25
Early congenital syphilis. 61
17893354 2007
26
Resurgence of early congenital syphilis in Alberta. 61
17606936 2007
27
Early congenital syphilis presented with exclusive bending pain of extremity: case report. 61
17291306 2007
28
Early diffuse alopecia in a neonate with congenital syphilis. 61
17155999 2006
29
Early congenital syphilis and erythema multiforme-like bullous targetoid lesions in a 1-day-old newborn: detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction. 61
16843116 2006
30
[Molecular detection and subtyping of Treponema pallidum subsp. pallidum in clinical specimens]. 61
16970074 2006
31
[Issues of congenital syphilis in the past twenty years. II. Clinical picture]. 61
16649151 2006
32
[Direct detection of Treponema pallidum in diagnosis of syphilis]. 61
15524270 2004
33
EARLY CONGENITAL SYPHILIS: FORGOTTEN BUT NOT. 61
27407631 2004
34
[Sepsis, disseminated intravascular coagulation (DIC) and hematological aspects as an unusual manifestation of congenital syphilis]. 61
12696466 2003
35
Early congenital syphilis in the new millennium. 61
12047653 2002
36
Congenital syphilis following negative antenatal screening. 61
12070982 2002
37
A case of early congenital syphilis. 61
12077542 2002
38
Early congenital syphilis. 61
11422526 2001
39
[Clinical picture of early congenital syphilis in 2,5-month-old infant]. 61
11928561 2001
40
[Syphilis in Europe in antiquity: the fetus of Costebelle and other new gifts from osteoarchaeology]. 61
11624590 2000
41
Unusual presentation of congenital syphilis. 61
10945059 2000
42
Haemophagocytosis in early congenital syphilis. 61
10412813 1999
43
Syphilis in pregnant women and their children in the United Kingdom: results from national clinician reporting surveys 1994-7. 61
9848899 1998
44
Early congenital syphilis--a continuing problem in Malaysia. 61
7565181 1995
45
Skeletal lesions in early congenital syphilis (a review of 86 cases). 61
7552208 1995
46
Brief communication: a case of congenital syphilis during the colonial period in Mexico City. 61
7653507 1995
47
Unusual presentation in early congenital syphilis. 61
7890350 1994
48
Congenital syphilitic skeletal manifestations in a premature infant revisited. 61
8324979 1993
49
Criteria for early congenital syphilis--a perspective from Africa. 61
1427797 1992
50
Neonatal and post-neonatal onset of early congenital syphilis: a report from Mozambique. 61
1283676 1992

Variations for Early Congenital Syphilis

Expression for Early Congenital Syphilis

Search GEO for disease gene expression data for Early Congenital Syphilis.

Pathways for Early Congenital Syphilis

Pathways related to Early Congenital Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.51 FOXP3 CCL4
2 10 FLT1 ANGPT1

GO Terms for Early Congenital Syphilis

Cellular components related to Early Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 FLT1 F2 ENG CRP CCL4 ANGPT1

Biological processes related to Early Congenital Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.43 F2 ENG ANGPT1
2 sprouting angiogenesis GO:0002040 9.32 ENG ANGPT1
3 positive regulation of gene expression GO:0010628 9.26 FOXP3 ENG CRP ANGPT1
4 positive regulation of collagen biosynthetic process GO:0032967 9.16 F2 ENG
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.8 FLT1 F2 ANGPT1

Sources for Early Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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