MCID: ERL002
MIFTS: 22

Early Congenital Syphilis

Categories: Bone diseases, Fetal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Early Congenital Syphilis

MalaCards integrated aliases for Early Congenital Syphilis:

Name: Early Congenital Syphilis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050488
UMLS 74 C0275859

Summaries for Early Congenital Syphilis

Disease Ontology : 12 A congenital syphilis that is manifested during the first 3 months of life. The infection has symptom skin lesions, has symptom lymphadenopathy, has symptom hepatosplenomegaly, has symptom failure to thrive, has symptom blood-stained nasal discharge, has symptom perioral fissures, has symptom meningitis, has symptom choroiditis, has symptom hydrocephalus, has symptom seizures, has symptom intellectual disability, has symptom osteochondritis, and has symptom pseudoparalysis.

MalaCards based summary : Early Congenital Syphilis is related to syphilis and congenital syphilis, and has symptoms including hydrocephalus, intellectual disability and seizures. An important gene associated with Early Congenital Syphilis is MYH9 (Myosin Heavy Chain 9). Affiliated tissues include skin, bone and liver.

Related Diseases for Early Congenital Syphilis

Diseases in the Syphilis family:

Early Congenital Syphilis Late Congenital Syphilis
Primary Syphilis Secondary Syphilis
Congenital Syphilis

Diseases related to Early Congenital Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 syphilis 10.7
2 congenital syphilis 10.7
3 thrombocytopenia 9.8
4 erythema multiforme 9.8

Symptoms & Phenotypes for Early Congenital Syphilis

Symptoms:

12 (show all 13)
  • hydrocephalus
  • intellectual disability
  • seizures
  • failure to thrive
  • meningitis
  • lymphadenopathy
  • hepatosplenomegaly
  • skin lesions
  • blood-stained nasal discharge
  • perioral fissures
  • choroiditis
  • osteochondritis
  • pseudoparalysis

Drugs & Therapeutics for Early Congenital Syphilis

Search Clinical Trials , NIH Clinical Center for Early Congenital Syphilis

Genetic Tests for Early Congenital Syphilis

Anatomical Context for Early Congenital Syphilis

MalaCards organs/tissues related to Early Congenital Syphilis:

42
Skin, Bone, Liver, Testes

Publications for Early Congenital Syphilis

Articles related to Early Congenital Syphilis:

(show all 48)
# Title Authors Year
1
Early Congenital Syphilis: Recognising Symptoms of an Increasingly Prevalent Disease. ( 28821219 )
2018
2
Skin rash: a manifestation of early congenital syphilis. ( 27268292 )
2016
3
Symptomatic Early Congenital Syphilis: A Common but Forgotten Disease. ( 26522203 )
2015
4
Early congenital syphilis presenting with vesicobullous eruptions beyond palmoplantar regions. ( 24037177 )
2014
5
Seroreversion of treponemal tests in infants meeting canadian surveillance criteria for confirmed early congenital syphilis. ( 22976052 )
2013
6
Varied presentations of early congenital syphilis. ( 23306406 )
2013
7
Early congenital syphilis in a premature newborn: typical cutaneous manifestations in atypical skin areas. ( 22331208 )
2012
8
Picture of the month-quiz case. Early congenital syphilis. ( 22869409 )
2012
9
Symptomatic early congenital syphilis: a common but forgotten disease. ( 23094175 )
2012
10
Early congenital syphilis in a premature baby. ( 21107603 )
2011
11
Early congenital syphilis presenting with skin eruption alone: a case report. ( 22323908 )
2011
12
Early congenital syphilis with isolated bone involvement: a case report. ( 19480330 )
2009
13
Early congenital syphilis presented with exclusive bending pain of extremity: case report. ( 17291306 )
2007
14
Resurgence of early congenital syphilis in Alberta. ( 17606936 )
2007
15
Early congenital syphilis. ( 17893354 )
2007
16
Early congenital syphilis and erythema multiforme-like bullous targetoid lesions in a 1-day-old newborn: detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction. ( 16843116 )
2006
17
EARLY CONGENITAL SYPHILIS: FORGOTTEN BUT NOT. ( 27407631 )
2004
18
Early congenital syphilis in the new millennium. ( 12047653 )
2002
19
A case of early congenital syphilis. ( 12077542 )
2002
20
Early congenital syphilis. ( 11422526 )
2001
21
Haemophagocytosis in early congenital syphilis. ( 10412813 )
1999
22
Skeletal lesions in early congenital syphilis (a review of 86 cases). ( 7552208 )
1995
23
Early congenital syphilis--a continuing problem in Malaysia. ( 7565181 )
1995
24
Unusual presentation in early congenital syphilis. ( 7890350 )
1994
25
Neonatal and post-neonatal onset of early congenital syphilis: a report from Mozambique. ( 1283676 )
1992
26
Criteria for early congenital syphilis--a perspective from Africa. ( 1427797 )
1992
27
Early congenital syphilis: experience with 13 consecutive cases seen at the University Hospital, Kuala Lumpur. ( 1775999 )
1991
28
Liver function in early congenital syphilis: does penicillin cause a deterioration? ( 2072220 )
1991
29
Early congenital syphilis and severe haematological disturbance. ( 3674927 )
1987
30
Failure of benzathine penicillin G treatment in early congenital syphilis. ( 3696844 )
1987
31
Early congenital syphilis still occurs. ( 3707199 )
1986
32
Palmoplantar milia: sequelae of early congenital syphilis. ( 3809024 )
1986
33
Early congenital syphilis still occurs. ( 3841473 )
1985
34
Early congenital syphilis: clinico-radiologic features in 202 patients. ( 4081939 )
1985
35
Early congenital syphilis (a review). ( 6673413 )
1983
36
Questionnaire survey of reported early congenital syphilis: problems in diagnosis, prevention, and treatment. ( 594857 )
1977
37
Early congenital syphilis. ( 1061882 )
1976
38
Bone lesions in early congenital syphilis. ( 1251290 )
1976
39
The re-emergence of early congenital syphilis. ( 4765579 )
1973
40
Early congenital syphilis and thrombocytopenia. ( 4171288 )
1968
41
Jarisch-Herxheimer reaction following penicillin treatment of early congenital syphilis. ( 13364287 )
1956
42
Penicillin treatment for early congenital syphilis. ( 14350886 )
1955
43
Fever in early congenital syphilis. ( 13196895 )
1954
44
On the significance of growth in the roentgenological skeletal changes in early congenital syphilis. ( 13030910 )
1953
45
The Jarisch-Herxheimer reaction in early congenital syphilis; a study of 93 patients treated with penicillin alone. ( 18121295 )
1949
46
Penicillin treatment of early congenital syphilis. ( 18864494 )
1948
47
An evaluation of the penicillin treatment in early congenital syphilis. ( 18916945 )
1948
48
Early congenital syphilis; treatment of two hundred and fifty-two patients with penicillin. ( 20277553 )
1947

Variations for Early Congenital Syphilis

Expression for Early Congenital Syphilis

Search GEO for disease gene expression data for Early Congenital Syphilis.

Pathways for Early Congenital Syphilis

GO Terms for Early Congenital Syphilis

Sources for Early Congenital Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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