Early Invasive Cervical Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Early Invasive Cervical Adenocarcinoma

MalaCards integrated aliases for Early Invasive Cervical Adenocarcinoma:

Name: Early Invasive Cervical Adenocarcinoma ¹¹ ¹⁴ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:8307

NCIt ⁴⁹ C36096

UMLS ⁷¹ C1333369

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Summaries for Early Invasive Cervical Adenocarcinoma

Disease Ontology: ¹¹ A cervical adenocarcinoma that is characterized by tumor cells that are identical to those in adenocarcinoma in situ (ACIS) and mcroscopic findings that suggest invasion.

MalaCards based summary: Early Invasive Cervical Adenocarcinoma is related to cervical adenocarcinoma and adenocarcinoma. An important gene associated with Early Invasive Cervical Adenocarcinoma is INSM1 (INSM Transcriptional Repressor 1), and among its related pathways/superpathways are Intrinsic Pathway for Apoptosis and Senescence and autophagy in cancer. Affiliated tissues include cervix, and related phenotype is digestive/alimentary.

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Related Diseases for Early Invasive Cervical Adenocarcinoma

Diseases in the Cervical Adenocarcinoma family:

Early Invasive Cervical Adenocarcinoma

Diseases related to Early Invasive Cervical Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)

#	Related Disease	Score	Top Affiliating Genes
1	cervical adenocarcinoma	30.1	INSM1 CDKN2A
2	adenocarcinoma	10.0
3	suppressor of tumorigenicity 3	9.9	CDKN2A BCL2
4	gallbladder small cell carcinoma	9.9	CDKN2A BCL2
5	borst-jadassohn intraepidermal carcinoma	9.9	CDKN2A BCL2
6	hypopharynx cancer	9.9	CDKN2A BCL2
7	respiratory system benign neoplasm	9.9	CDKN2A BCL2
8	actinic keratosis	9.9	CDKN2A BCL2
9	keratosis	9.9	CDKN2A BCL2
10	uterine benign neoplasm	9.9	CDKN2A BCL2
11	reproductive organ benign neoplasm	9.9	CDKN2A BCL2
12	female breast cancer	9.9	CDKN2A BCL2
13	oropharynx cancer	9.8	CDKN2A BCL2
14	childhood acute lymphocytic leukemia	9.8	CDKN2A BCL2
15	muscle cancer	9.8	CDKN2A BCL2
16	intestinal benign neoplasm	9.8	CDKN2A BCL2
17	endometrial hyperplasia	9.8	CDKN2A BCL2
18	mature b-cell neoplasm	9.8	CDKN2A BCL2
19	leiomyosarcoma	9.8	CDKN2A BCL2
20	plasmacytoma	9.8	CDKN2A BCL2
21	teratoma	9.8	CDKN2A BCL2
22	liposarcoma	9.8	CDKN2A BCL2
23	retinal cancer	9.8	CDKN2A BCL2
24	colonic benign neoplasm	9.8	CDKN2A BCL2
25	malignant pleural mesothelioma	9.8	CDKN2A BCL2
26	tongue disease	9.8	CDKN2A BCL2
27	papillary squamous carcinoma	9.8	INSM1 CDKN2A
28	thymoma	9.8	CDKN2A BCL2
29	fallopian tube endometrioid adenocarcinoma	9.8	INSM1 CDKN2A
30	chronic cervicitis	9.8	INSM1 CDKN2A
31	li-fraumeni syndrome	9.8	CDKN2A BCL2
32	basaloid squamous cell carcinoma	9.8	INSM1 CDKN2A
33	vaginal cancer	9.8	INSM1 CDKN2A
34	tongue carcinoma	9.8	CDKN2A BCL2
35	uterus carcinoma in situ	9.8	INSM1 CDKN2A
36	cervix uteri carcinoma in situ	9.8	INSM1 CDKN2A
37	adenocarcinoma in situ	9.8	INSM1 CDKN2A
38	breast adenocarcinoma	9.8	CDKN2A BCL2
39	papilloma	9.8	CDKN2A BCL2
40	endocervical carcinoma	9.8	INSM1 CDKN2A
41	mantle cell lymphoma	9.8	CDKN2A BCL2
42	oligodendroglioma	9.8	CDKN2A BCL2
43	endocervical adenocarcinoma	9.8	INSM1 CDKN2A
44	gastric adenocarcinoma	9.8	CDKN2A BCL2
45	paraganglioma	9.8	CDKN2A BCL2
46	hemangioma	9.8	CDKN2A BCL2
47	adenoid cystic carcinoma	9.8	CDKN2A BCL2
48	follicular lymphoma	9.8	CDKN2A BCL2
49	laryngeal squamous cell carcinoma	9.8	CDKN2A BCL2
50	adrenal cortical carcinoma	9.8	CDKN2A BCL2

Graphical network of the top 20 diseases related to Early Invasive Cervical Adenocarcinoma:

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Symptoms & Phenotypes for Early Invasive Cervical Adenocarcinoma

MGI Mouse Phenotypes related to Early Invasive Cervical Adenocarcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	8.8	BCL2 CDKN2A INSM1

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Drugs & Therapeutics for Early Invasive Cervical Adenocarcinoma

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Prevalence of Anal Dysplasia and Anal Cancer in Women With Cervical, Vaginal and Vulvar Dysplasia and Cancer	Recruiting	NCT02140021

Search NIH Clinical Center for Early Invasive Cervical Adenocarcinoma

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Genetic Tests for Early Invasive Cervical Adenocarcinoma

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Anatomical Context for Early Invasive Cervical Adenocarcinoma

Organs/tissues related to Early Invasive Cervical Adenocarcinoma:

MalaCards : Cervix

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Publications for Early Invasive Cervical Adenocarcinoma

Articles related to Early Invasive Cervical Adenocarcinoma:

#	Title	Authors	PMID	Year
1	Surgical treatment and outcome of early invasive adenocarcinoma of the uterine cervix (FIGO stage IA1). ⁶²	Yahata H...Kato K	28429457	2018
2	[Cervical glandular intraepithelial neoplasia: a clinicopathologic and immunohistochemical analysis of 80 cases]. ⁶²	Luo R...Zhu LY	23611270	2013
3	Early invasive cervical adenocarcinoma: its potential for nodal metastasis or recurrence. ⁶²	Hirai Y...Hasumi K	12628261	2003
4	Is the invasion depth in millimeters valid to determine the prognosis of early invasive cervical adenocarcinoma? A case of recurrent FIGO stage IA1 cervical adenocarcinoma. ⁶²	Utsugi K...Hasumi K	11426988	2001
5	Early invasive adenocarcinoma of the cervix. ⁶²	Lee KR...Flynn CE	10964335	2000
6	[Retrospective analysis of cytology in a case with early invasive cervical adenocarcinoma]. ⁶²	Utsugi K...Hiroi M	8568362	1995

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Genes for Early Invasive Cervical Adenocarcinoma

Genes related to Early Invasive Cervical Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	INSM1	INSM Transcriptional Repressor 1	Protein Coding	6.65	DISEASES inferred ¹⁴
2	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	4.13	DISEASES inferred ¹⁴
3	BCL2	BCL2 Apoptosis Regulator	Protein Coding	3.7	DISEASES inferred ¹⁴

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Variations for Early Invasive Cervical Adenocarcinoma

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Expression for Early Invasive Cervical Adenocarcinoma

Search GEO for disease gene expression data for Early Invasive Cervical Adenocarcinoma.

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Pathways for Early Invasive Cervical Adenocarcinoma

Pathways related to Early Invasive Cervical Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Intrinsic Pathway for Apoptosis ⁶⁶ Show member pathways Activation of BAD and translocation to mitochondria ⁶⁶ Activation of BH3-only proteins ⁶⁶ Activation of BIM and translocation to mitochondria ⁶⁶ Activation of BMF and translocation to mitochondria ⁶⁶ Activation of NOXA and translocation to mitochondria ⁶⁶ Activation of PUMA and translocation to mitochondria ⁶⁶ Activation, myristolyation of BID and translocation to mitochondria ⁶⁶ Apoptotic factor-mediated response ⁶⁶ BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members ⁶⁶ Cytochrome c-mediated apoptotic response ⁶⁶ Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function ⁶⁶ Release of apoptotic factors from the mitochondria ⁶⁶ SMAC, XIAP-regulated apoptotic response ⁶⁶	11.58	CDKN2A BCL2
2	Senescence and autophagy in cancer ⁷⁴	11.18	CDKN2A BCL2
3	Transcription_P53 signaling pathway ²²	10.99	CDKN2A BCL2
4	C-MYB transcription factor network ⁶¹	10.86	CDKN2A BCL2
5	TP53 network ⁷⁴ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁶	9.92	CDKN2A BCL2

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GO Terms for Early Invasive Cervical Adenocarcinoma

Biological processes related to Early Invasive Cervical Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell growth	GO:0030308	9.62	CDKN2A BCL2
2	negative regulation of cell population proliferation	GO:0008285	9.55	INSM1 CDKN2A BCL2
3	regulation of protein stability	GO:0031647	9.43	CDKN2A BCL2
4	regulation of cell cycle	GO:0051726	9.35	INSM1 CDKN2A BCL2
5	apoptotic mitochondrial changes	GO:0008637	8.62	CDKN2A BCL2

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Sources for Early Invasive Cervical Adenocarcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

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⁸ Cosmic

⁹ dbSNP

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¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ERL005 MIFTS: 22	Early Invasive Cervical Adenocarcinoma Categories: Cancer diseases, Rare diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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