MCID: ERL056
MIFTS: 39

Early-Onset Parkinson's Disease

Categories: Genetic diseases, Mental diseases, Metabolic diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Early-Onset Parkinson's Disease

MalaCards integrated aliases for Early-Onset Parkinson's Disease:

Name: Early-Onset Parkinson's Disease 12 15
Early-Onset Parkinson Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060894

Summaries for Early-Onset Parkinson's Disease

Disease Ontology : 12 A Parkinson's disease characterized by onset of motor symptoms early than typically seen, usually prior to 50 years of age.

MalaCards based summary : Early-Onset Parkinson's Disease, also known as early-onset parkinson disease, is related to parkinson disease 6, autosomal recessive early-onset and parkinson disease 15, autosomal recessive early-onset. An important gene associated with Early-Onset Parkinson's Disease is PINK1 (PTEN Induced Kinase 1), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Neuroscience. The drugs insulin and Insulin, Globin Zinc have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and skin, and related phenotypes are behavior/neurological and cellular

Related Diseases for Early-Onset Parkinson's Disease

Diseases in the Parkinson Disease, Late-Onset family:

Parkinson Disease 1, Autosomal Dominant Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinson Disease 12 Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinson Disease 3, Autosomal Dominant Parkinson Disease 4, Autosomal Dominant
Parkinson Disease 6, Autosomal Recessive Early-Onset Parkinson Disease 7, Autosomal Recessive Early-Onset
Parkinson Disease 10 Parkinson Disease 8, Autosomal Dominant
Parkinson Disease 11, Autosomal Dominant Parkinson Disease 13, Autosomal Dominant
Parkinson Disease 14, Autosomal Recessive Parkinson Disease 16
Parkinson Disease 5, Autosomal Dominant Parkinson Disease 17
Parkinson Disease 18, Autosomal Dominant Parkinson Disease 19a, Juvenile-Onset
Parkinson Disease 20, Early-Onset Parkinson Disease 21
Parkinson Disease 22, Autosomal Dominant Parkinson Disease 23, Autosomal Recessive Early-Onset
Juvenile-Onset Parkinson's Disease Early-Onset Parkinson's Disease
Vps35-Related Parkinson Disease Hereditary Late-Onset Parkinson Disease

Diseases related to Early-Onset Parkinson's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 parkinson disease 6, autosomal recessive early-onset 34.2 PINK1-AS PINK1 PARK7
2 parkinson disease 15, autosomal recessive early-onset 32.4 SNCA PRKN PLA2G6 PINK1 PARK7 LRRK2
3 parkinson disease 2, autosomal recessive juvenile 32.0 VPS13C SNCA PRKN PINK1 PARK7 LRRK2
4 kufor-rakeb syndrome 31.8 SNCA PRKN PLA2G6 PINK1 PARK7 LRRK2
5 juvenile-onset parkinson's disease 31.6 SNCA PRKN PLA2G6 PINK1 PARK7 LRRK2
6 tremor 31.0 SNCA PRKN LRRK2 GBA
7 lrrk2 parkinson disease 30.5 SNCA PRKN LRRK2
8 parkinson disease 3, autosomal dominant 30.3 SNCA PRKN PARK7 LRRK2
9 hyperphenylalaninemia, bh4-deficient, b 30.3 TH GCH1
10 gaucher's disease 30.2 SNCA PRKN GBA
11 essential tremor 30.2 SNCA PRKN LRRK2 GBA
12 hereditary late-onset parkinson disease 30.2 SNCA LRRK2 GIGYF2 GBA
13 dystonia 29.9 TH PRKN PLA2G6 PINK1 PARK7 LRRK2
14 postencephalitic parkinson disease 29.8 TH SNCA PRKN PINK1 PARK7 LRRK2
15 dementia, lewy body 29.3 TH SNCA PRKN PINK1 PARK7 LRRK2
16 movement disease 29.2 TH SNCA PRKN PLA2G6 PINK1 PARK7
17 neurodegeneration with brain iron accumulation 28.7 TH SNCA PRKN PLA2G6 PINK1 PARK7
18 parkinson disease, late-onset 27.3 VPS13C TH SNCA RAB39B PRKN PLA2G6
19 parkinson disease 7, autosomal recessive early-onset 12.1
20 parkinson disease 19a, juvenile-onset 11.9
21 waisman syndrome 11.7
22 parkinson disease 23, autosomal recessive early-onset 11.7
23 parkinson disease 20, early-onset 11.5
24 hyperphenylalaninemia, mild, non-bh4-deficient 11.2
25 parkin type of early-onset parkinson disease 10.4
26 parkinson disease, mitochondrial 10.4 PRKN LRRK2
27 muscular dystrophy, congenital, megaconial type 10.4 PRKN PINK1
28 glottis squamous cell carcinoma 10.3 PTEN PARK7
29 rem sleep behavior disorder 10.3 SNCA LRRK2 GBA
30 neurodegeneration with brain iron accumulation 2a 10.3 SNCA PLA2G6 ATP13A2
31 neurodegeneration with brain iron accumulation 1 10.3 SNCA PLA2G6 ATP13A2
32 neuroaxonal dystrophy 10.2 SNCA PLA2G6 ATP13A2
33 krabbe disease 10.2 SNCA PLA2G6 GBA
34 testicular disease 10.2 PRKN PACRG LRRK2
35 pick disease of brain 10.2 SNCA PRKN PARK7 LRRK2
36 segawa syndrome, autosomal recessive 10.2 TH GCH1
37 leprosy 3 10.2 PRKN PACRG LRRK2
38 dopamine beta-hydroxylase deficiency 10.2 TH GCH1
39 hereditary dystonia 10.2 TH GCH1 ATP13A2
40 parkinson disease 10 10.2 SNCA PRKN PINK1 PARK7 LRRK2
41 tetrahydrobiopterin deficiency 10.1 TH GCH1
42 oromandibular dystonia 10.1 PLA2G6 GCH1
43 leber optic atrophy 10.1 SNCA PRKN PINK1 PARL
44 multiple system atrophy 1 10.1 TH SNCA PRKN LRRK2
45 alacrima, achalasia, and mental retardation syndrome 10.1
46 digeorge syndrome 10.1
47 pink1 type of young-onset parkinson disease 10.1
48 gangliocytoma 10.0 TH PTEN
49 dystonia 12 9.9 SNCA PRKN PINK1 PARK7 GCH1 ATP13A2
50 parkinson disease 1, autosomal dominant 9.9

Graphical network of the top 20 diseases related to Early-Onset Parkinson's Disease:



Diseases related to Early-Onset Parkinson's Disease

Symptoms & Phenotypes for Early-Onset Parkinson's Disease

MGI Mouse Phenotypes related to Early-Onset Parkinson's Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.33 ATP13A2 FBXO7 GBA GIGYF2 LRRK2 PARK7
2 cellular MP:0005384 10.22 ATP13A2 FBXO7 GBA GIGYF2 LRRK2 PARK7
3 cardiovascular system MP:0005385 10.21 ATP13A2 GBA GCH1 LRRK2 PARL PINK1
4 homeostasis/metabolism MP:0005376 10.13 ATP13A2 FBXO7 GBA GCH1 GIGYF2 LRRK2
5 growth/size/body region MP:0005378 10.1 DNAJC6 GBA GIGYF2 PARK7 PARL PINK1
6 endocrine/exocrine gland MP:0005379 10.02 FBXO7 GBA LRRK2 PARL PINK1 PTEN
7 mortality/aging MP:0010768 10 DNAJC6 FBXO7 GBA GCH1 GIGYF2 LRRK2
8 nervous system MP:0003631 9.83 ATP13A2 DNAJC6 GBA GCH1 GIGYF2 LRRK2
9 skeleton MP:0005390 9.28 GBA LRRK2 PARL PINK1 PLA2G6 PRKN

Drugs & Therapeutics for Early-Onset Parkinson's Disease

Drugs for Early-Onset Parkinson's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 insulin
2 Insulin, Globin Zinc

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genetic Epidemiology of Parkinson's Disease Unknown status NCT00104585
2 Hereditary Parkinson's Disease Natural History Protocol Completed NCT02511015
3 The Chinese Early-onset Parkinson's Disease Registry Recruiting NCT03508960
4 Parkinson's Families Project Recruiting NCT02760108
5 Decrement of the Dual-task Performance in Individuals With Young-onset Parkinson's Disease and the Training Effects Not yet recruiting NCT04033393
6 Metabolic Phenotyping of Subjects With Mutations Associated With Hereditary Parkinson's Disease Terminated NCT01547832

Search NIH Clinical Center for Early-Onset Parkinson's Disease

Genetic Tests for Early-Onset Parkinson's Disease

Anatomical Context for Early-Onset Parkinson's Disease

MalaCards organs/tissues related to Early-Onset Parkinson's Disease:

40
Brain, Cortex, Skin, Breast, Eye, Lung, Prostate

Publications for Early-Onset Parkinson's Disease

Articles related to Early-Onset Parkinson's Disease:

(show top 50) (show all 467)
# Title Authors PMID Year
1
Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice. 61
31846738 2020
2
Digitized Image Analysis of Insula Echogenicity Detected by TCS-MR Fusion Imaging in Wilson's and Early-Onset Parkinson's Diseases. 61
31924422 2020
3
Non-motor Symptoms in Parkinson's Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction. 61
31927768 2020
4
Mutation analysis of CAPN1 in Chinese populations with spastic paraplegia and related neurodegenerative diseases. 61
31982778 2020
5
A VPS13D spastic ataxia mutation disrupts the conserved adaptor binding site in yeast Vps13. 61
31943017 2020
6
ATP13A2 deficiency disrupts lysosomal polyamine export. 61
31996848 2020
7
Brain mitochondrial impairment in early-onset Parkinson's disease with or without PINK1 mutation. 61
31898835 2020
8
DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1. 61
31767755 2019
9
PINK1 Silencing Modifies Dendritic Spine Dynamics of Mouse Hippocampal Neurons. 61
31486971 2019
10
Preserved Serotonergic Activity in Early-Onset Parkinson's Disease. 61
31685057 2019
11
Neurobiological perspective of 22q11.2 deletion syndrome. 61
31395526 2019
12
[Analysis of a patient with early-onset Parkinson's disease and PARK7 gene variation]. 61
31598935 2019
13
Recurrent NUS1 canonical splice donor site mutation in two unrelated individuals with epilepsy, myoclonus, ataxia and scoliosis - a case report. 61
31656175 2019
14
Han Chinese family with early-onset Parkinson's disease carries novel compound heterozygous mutations in the PARK2 gene. 61
31386307 2019
15
Expanding the canvas of PRKN mutations in familial and early-onset Parkinson disease. 61
31409571 2019
16
The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson's disease. 61
30994895 2019
17
Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP. 61
30734931 2019
18
Case of Early-Onset Parkinson's Disease in a Heterozygous Mutation Carrier of the ATP7B Gene. 61
31426520 2019
19
Familial early onset Parkinson's disease caused by a homozygous frameshift variant in PARK7: Clinical features and literature update. 61
30928208 2019
20
Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease. 61
30995519 2019
21
PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model. 61
30088174 2019
22
Asymptomatic Hearing Impairment Frequently Occurs in Early-Onset Parkinson's Disease. 61
30944288 2019
23
Reprogramming of a human induced pluripotent stem cell (iPSC) line (IBMSi012-A) from an early-onset Parkinson's disease patient harboring a homozygous p.D331Y mutation in the PLA2G6 gene. 61
30978640 2019
24
Genetic variants of PARK genes in Korean patients with early-onset Parkinson's disease. 61
30502028 2019
25
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1. 61
30733118 2019
26
Label-free detection of early oligomerization of α-synuclein and its mutants A30P/E46K through solid-state nanopores. 61
30892349 2019
27
Protein damage, ageing and age-related diseases. 61
30914006 2019
28
RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells. 61
30634017 2019
29
Different patterns of gray matter density in early- and middle-late-onset Parkinson's disease: a voxel-based morphometry study. 61
28667375 2019
30
A30P mutant α-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons. 61
30755581 2019
31
Compound heterozygous mutations in PARK2 causing early-onset Parkinson disease: A case report. 61
30702579 2019
32
22q11.2 Deletion Syndrome-Associated Parkinson's Disease. 61
30746410 2019
33
Utility and implications of exome sequencing in early-onset Parkinson's disease. 61
30537300 2019
34
Haplotype Analysis on the Relationship of the DNAJC6 Gene with Early-Onset Parkinson's Disease Risk in a Chinese Population. 61
30373961 2019
35
The Interaction of Genetic Mutations in PARK2 and FA2H Causes a Novel Phenotype in a Case of Childhood-Onset Movement Disorder. 61
31191442 2019
36
Analysis of Exon Dosage Using Multiplex Ligation-Dependent Probe Amplification in Chinese Patients with Early-Onset Parkinson's Disease. 61
31618739 2019
37
Novel Compound Heterozygous PRKN Variants in a Han-Chinese Family with Early-Onset Parkinson's Disease. 61
31929871 2019
38
Early-Onset Parkinson's Disease Caused by PLA2G6 Compound Heterozygous Mutation, a Case Report and Literature Review. 61
31496990 2019
39
Mitochondrial Protein PINK1 Positively Regulates RLR Signaling. 61
31139191 2019
40
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy. 61
30573668 2019
41
Early Dyskinesias in Parkinson's Disease Patients With Parkin Mutation: A Primary Corticostriatal Synaptopathy? 61
30971883 2019
42
Cell Ratio Differences in Peripheral Blood between Early- and Late-Onset Parkinson's Disease: A Case-Control Study. 61
31781596 2019
43
Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation. 61
30446597 2018
44
Chemical Strategies for Activating PINK1, a Protein Kinase Mutated in Parkinson's Disease. 61
30248222 2018
45
Molecular characterization of PRKN structural variations identified through whole-genome sequencing. 61
30328284 2018
46
Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction. 61
30338296 2018
47
Genetic analysis of ATP13A2, PLA2G6 and FBXO7 in a cohort of Chinese patients with early-onset Parkinson's disease. 61
30232368 2018
48
Loss of the mitochondrial kinase PINK1 does not alter platelet function. 61
30258205 2018
49
Parkin-dependent regulation of the MCU complex component MICU1. 61
30242232 2018
50
Parkin and PINK1 mitigate STING-induced inflammation. 61
30135585 2018

Variations for Early-Onset Parkinson's Disease

Expression for Early-Onset Parkinson's Disease

Search GEO for disease gene expression data for Early-Onset Parkinson's Disease.

Pathways for Early-Onset Parkinson's Disease

Pathways related to Early-Onset Parkinson's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.26 SNCA SEPTIN5 PRKN PINK1 PARK7
2 12.09 TH SNCA PRKN PINK1 PARK7 LRRK2
3 11.09 TH SNCA SEPTIN5 PRKN PINK1 PARK7
4 10.96 TH SNCA PRKN PARK7

GO Terms for Early-Onset Parkinson's Disease

Cellular components related to Early-Onset Parkinson's Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.38 VPS13C TH SNCA SEPTIN5 PTEN PRKN
2 cytosol GO:0005829 10.17 VPS13C TH SNCA PTEN PRKN PLA2G6
3 axon GO:0030424 9.89 TH SNCA PINK1 PARK7 LRRK2
4 cell GO:0005623 9.86 VPS13C TH SNCA PRKN PLA2G6 PARK7
5 mitochondrial outer membrane GO:0005741 9.78 VPS13C SNCA PINK1 LRRK2
6 presynapse GO:0098793 9.71 SNCA PRKN PARK7 DNAJC6
7 cell body GO:0044297 9.7 PINK1 PARK7 PACRG
8 mitochondrion GO:0005739 9.7 VPS13C TH SNCA PTEN PRKN PLA2G6
9 mitochondrial intermembrane space GO:0005758 9.69 SNCA PINK1 PARK7
10 synaptic vesicle GO:0008021 9.67 TH SNCA SEPTIN5 LRRK2
11 terminal bouton GO:0043195 9.63 TH SNCA LRRK2
12 vesicle GO:0031982 9.55 RAB39B PACRG GIGYF2 DNAJC6 ATP13A2
13 Lewy body GO:0097413 9.43 PRKN PINK1
14 neuron projection GO:0043005 9.23 TH RAB39B PTEN PRKN PARK7 PACRG

Biological processes related to Early-Onset Parkinson's Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 protein stabilization GO:0050821 9.97 PTEN PRKN PINK1 PARK7
2 negative regulation of neuron apoptotic process GO:0043524 9.94 SNCA PRKN PINK1 PARK7
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.89 PTEN PINK1 PARK7
4 regulation of protein stability GO:0031647 9.89 PTEN PRKN LRRK2 FBXO7
5 cellular response to oxidative stress GO:0034599 9.89 SNCA PINK1 PARK7 LRRK2 ATP13A2
6 locomotory behavior GO:0007626 9.87 TH PTEN PRKN
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.87 SNCA PINK1 PARK7
8 memory GO:0007613 9.87 TH PTEN PLA2G6
9 adult locomotory behavior GO:0008344 9.87 SNCA PRKN PARK7 GIGYF2
10 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.86 PRKN LRRK2 GBA
11 negative regulation of cell death GO:0060548 9.86 PRKN PARK7 PACRG
12 regulation of autophagy GO:0010506 9.85 RAB39B PRKN LRRK2
13 negative regulation of protein phosphorylation GO:0001933 9.85 SNCA PTEN PRKN PARK7 LRRK2
14 social behavior GO:0035176 9.83 TH SEPTIN5 PTEN
15 autophagy of mitochondrion GO:0000422 9.81 PRKN PINK1 FBXO7
16 regulation of mitochondrial membrane potential GO:0051881 9.79 PRKN PINK1 PARK7
17 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.76 PRKN PARK7 LRRK2
18 negative regulation of oxidative stress-induced neuron death GO:1903204 9.75 PINK1 PARK7 FBXO7
19 negative regulation of oxidative stress-induced cell death GO:1903202 9.73 PRKN PINK1 PARK7
20 regulation of reactive oxygen species metabolic process GO:2000377 9.73 SNCA PRKN PINK1 PARL
21 mitochondrion organization GO:0007005 9.73 VPS13C PRKN PINK1 PARK7 LRRK2 GBA
22 regulation of neuron death GO:1901214 9.72 SNCA LRRK2
23 regulation of protein ubiquitination GO:0031396 9.72 PRKN PINK1
24 dopamine biosynthetic process GO:0042416 9.72 TH SNCA GCH1
25 regulation of autophagy of mitochondrion GO:1903146 9.71 PINK1 ATP13A2
26 cellular response to dopamine GO:1903351 9.71 PRKN LRRK2
27 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.71 PARK7 LRRK2
28 negative regulation of autophagosome assembly GO:1902902 9.71 PINK1 LRRK2
29 regulation of locomotion GO:0040012 9.71 SNCA LRRK2 FBXO7
30 positive regulation of mitochondrial fission GO:0090141 9.7 PRKN PINK1
31 dopamine metabolic process GO:0042417 9.7 SNCA PRKN
32 negative regulation of macroautophagy GO:0016242 9.7 PINK1 LRRK2
33 positive regulation of autophagy of mitochondrion GO:1903599 9.7 PRKN PARK7 FBXO7
34 negative regulation of excitatory postsynaptic potential GO:0090394 9.69 PTEN LRRK2
35 regulation of protein targeting to mitochondrion GO:1903214 9.69 PRKN PINK1 PARL
36 cellular response to toxic substance GO:0097237 9.68 PRKN PINK1
37 protein localization to mitochondrion GO:0070585 9.67 PRKN LRRK2
38 positive regulation of histone deacetylase activity GO:1901727 9.67 PINK1 LRRK2
39 synaptic transmission, dopaminergic GO:0001963 9.67 TH SNCA PRKN PARK7
40 regulation of cellular response to oxidative stress GO:1900407 9.66 PRKN PINK1
41 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization GO:1904925 9.65 PINK1 GBA
42 positive regulation of mitophagy in response to mitochondrial depolarization GO:0098779 9.65 PRKN PINK1
43 zinc ion homeostasis GO:0055069 9.65 PRKN ATP13A2
44 dopamine uptake involved in synaptic transmission GO:0051583 9.65 SNCA PRKN PARK7
45 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 9.64 PRKN PARK7
46 autophagosome organization GO:1905037 9.63 GBA ATP13A2
47 positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958 9.62 PINK1 PARK7
48 mitochondrion to lysosome transport GO:0099074 9.62 PRKN PINK1
49 regulation of mitochondrion organization GO:0010821 9.62 PRKN PINK1 PARL ATP13A2
50 regulation of lysosomal protein catabolic process GO:1905165 9.61 GBA ATP13A2

Molecular functions related to Early-Onset Parkinson's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase activity GO:0003924 9.76 SEPTIN5 RAB39B LRRK2 GCH1
2 enzyme binding GO:0019899 9.72 TH SNCA PTEN PRKN PARK7
3 ubiquitin protein ligase binding GO:0031625 9.71 PRKN PINK1 PACRG FBXO7
4 hydrolase activity GO:0016787 9.61 PTEN PLA2G6 PARL PARK7 LRRK2 GCH1
5 phospholipase binding GO:0043274 9.43 SNCA PRKN
6 Hsp70 protein binding GO:0030544 9.43 SNCA PRKN PACRG
7 cuprous ion binding GO:1903136 9.37 SNCA PARK7
8 cupric ion binding GO:1903135 9.16 PARK7 ATP13A2
9 ubiquitin-specific protease binding GO:1990381 8.8 PTEN PRKN PARK7

Sources for Early-Onset Parkinson's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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