MCID: ERL036
MIFTS: 12

Early-Onset Posterior Subcapsular Cataract

Categories: Eye diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Early-Onset Posterior Subcapsular Cataract

MalaCards integrated aliases for Early-Onset Posterior Subcapsular Cataract:

Name: Early-Onset Posterior Subcapsular Cataract 60

Characteristics:

Orphanet epidemiological data:

60
early-onset posterior subcapsular cataract
Inheritance: Autosomal dominant;

Classifications:



External Ids:

ICD10 via Orphanet 35 H26.0
Orphanet 60 ORPHA441447

Summaries for Early-Onset Posterior Subcapsular Cataract

MalaCards based summary : Early-Onset Posterior Subcapsular Cataract is related to vitreoretinochoroidopathy and cataract 16, multiple types. An important gene associated with Early-Onset Posterior Subcapsular Cataract is UNC45B (Unc-45 Myosin Chaperone B). Affiliated tissues include eye.

Related Diseases for Early-Onset Posterior Subcapsular Cataract

Diseases related to Early-Onset Posterior Subcapsular Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vitreoretinochoroidopathy 11.4
2 cataract 16, multiple types 9.6 CHMP4B EPHA2
3 early-onset nuclear cataract 9.4 CRYBB2 EPHA2 UNC45B
4 cataract 44 9.3 CRYBB2 EPHA2 LEMD2
5 cataract 9.1 CRYBB2 EPHA2 LEMD2 UNC45B

Graphical network of the top 20 diseases related to Early-Onset Posterior Subcapsular Cataract:



Diseases related to Early-Onset Posterior Subcapsular Cataract

Symptoms & Phenotypes for Early-Onset Posterior Subcapsular Cataract

Drugs & Therapeutics for Early-Onset Posterior Subcapsular Cataract

Search Clinical Trials , NIH Clinical Center for Early-Onset Posterior Subcapsular Cataract

Genetic Tests for Early-Onset Posterior Subcapsular Cataract

Anatomical Context for Early-Onset Posterior Subcapsular Cataract

MalaCards organs/tissues related to Early-Onset Posterior Subcapsular Cataract:

42
Eye

Publications for Early-Onset Posterior Subcapsular Cataract

Variations for Early-Onset Posterior Subcapsular Cataract

Expression for Early-Onset Posterior Subcapsular Cataract

Search GEO for disease gene expression data for Early-Onset Posterior Subcapsular Cataract.

Pathways for Early-Onset Posterior Subcapsular Cataract

GO Terms for Early-Onset Posterior Subcapsular Cataract

Cellular components related to Early-Onset Posterior Subcapsular Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear envelope GO:0005635 8.62 CHMP4B LEMD2

Biological processes related to Early-Onset Posterior Subcapsular Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase B signaling GO:0051898 8.62 EPHA2 LEMD2

Molecular functions related to Early-Onset Posterior Subcapsular Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 8.62 CHMP4B EPHA2

Sources for Early-Onset Posterior Subcapsular Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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