MCID: ERL036
MIFTS: 13

Early-Onset Posterior Subcapsular Cataract

Categories: Eye diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Early-Onset Posterior Subcapsular Cataract

MalaCards integrated aliases for Early-Onset Posterior Subcapsular Cataract:

Name: Early-Onset Posterior Subcapsular Cataract 59

Characteristics:

Orphanet epidemiological data:

59
early-onset posterior subcapsular cataract
Inheritance: Autosomal dominant;

Classifications:



External Ids:

Orphanet 59 ORPHA441447
ICD10 via Orphanet 34 H26.0

Summaries for Early-Onset Posterior Subcapsular Cataract

MalaCards based summary : Early-Onset Posterior Subcapsular Cataract is related to vitreoretinochoroidopathy dominant and cataract 16, multiple types. An important gene associated with Early-Onset Posterior Subcapsular Cataract is UNC45B (Unc-45 Myosin Chaperone B). Affiliated tissues include eye.

Related Diseases for Early-Onset Posterior Subcapsular Cataract

Diseases related to Early-Onset Posterior Subcapsular Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vitreoretinochoroidopathy dominant 11.3
2 cataract 16, multiple types 9.2 CHMP4B EPHA2
3 early-onset nuclear cataract 8.7 CRYBB2 EPHA2 UNC45B
4 cataract 44 8.5 CRYBB2 EPHA2 LEMD2
5 cataract 7.5 CHMP4B CRYBB2 EPHA2 LEMD2 UNC45B

Graphical network of the top 20 diseases related to Early-Onset Posterior Subcapsular Cataract:



Diseases related to Early-Onset Posterior Subcapsular Cataract

Symptoms & Phenotypes for Early-Onset Posterior Subcapsular Cataract

Drugs & Therapeutics for Early-Onset Posterior Subcapsular Cataract

Search Clinical Trials , NIH Clinical Center for Early-Onset Posterior Subcapsular Cataract

Genetic Tests for Early-Onset Posterior Subcapsular Cataract

Anatomical Context for Early-Onset Posterior Subcapsular Cataract

MalaCards organs/tissues related to Early-Onset Posterior Subcapsular Cataract:

41
Eye

Publications for Early-Onset Posterior Subcapsular Cataract

Variations for Early-Onset Posterior Subcapsular Cataract

Expression for Early-Onset Posterior Subcapsular Cataract

Search GEO for disease gene expression data for Early-Onset Posterior Subcapsular Cataract.

Pathways for Early-Onset Posterior Subcapsular Cataract

GO Terms for Early-Onset Posterior Subcapsular Cataract

Cellular components related to Early-Onset Posterior Subcapsular Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear envelope GO:0005635 8.62 CHMP4B LEMD2

Biological processes related to Early-Onset Posterior Subcapsular Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase B signaling GO:0051898 8.62 EPHA2 LEMD2

Molecular functions related to Early-Onset Posterior Subcapsular Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 8.62 CHMP4B EPHA2

Sources for Early-Onset Posterior Subcapsular Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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