MCID: ERL036
MIFTS: 12

Early-Onset Posterior Subcapsular Cataract

Categories: Eye diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Early-Onset Posterior Subcapsular Cataract

MalaCards integrated aliases for Early-Onset Posterior Subcapsular Cataract:

Name: Early-Onset Posterior Subcapsular Cataract 58

Characteristics:

Orphanet epidemiological data:

58
early-onset posterior subcapsular cataract
Inheritance: Autosomal dominant;

Classifications:

Orphanet: 58  
Rare eye diseases
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 H26.0
Orphanet 58 ORPHA441447

Summaries for Early-Onset Posterior Subcapsular Cataract

MalaCards based summary : Early-Onset Posterior Subcapsular Cataract is related to vitreoretinochoroidopathy and early-onset posterior polar cataract. An important gene associated with Early-Onset Posterior Subcapsular Cataract is CHMP4B (Charged Multivesicular Body Protein 4B). Affiliated tissues include eye.

Related Diseases for Early-Onset Posterior Subcapsular Cataract

Diseases related to Early-Onset Posterior Subcapsular Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vitreoretinochoroidopathy 11.3
2 early-onset posterior polar cataract 9.8 EPHA2 CHMP4B
3 posterior polar cataract 9.7 EPHA2 CHMP4B
4 cataract 6, multiple types 9.6 EPHA2 CHMP4B
5 early-onset nuclear cataract 9.5 UNC45B EPHA2 CRYBB2
6 cataract 44 9.4 LEMD2 EPHA2 CRYBB2
7 early-onset non-syndromic cataract 9.1 UNC45B LEMD2 EPHA2 CHMP4B
8 cataract 8.9 UNC45B LEMD2 EPHA2 CRYBB2 CHMP4B

Graphical network of the top 20 diseases related to Early-Onset Posterior Subcapsular Cataract:



Diseases related to Early-Onset Posterior Subcapsular Cataract

Symptoms & Phenotypes for Early-Onset Posterior Subcapsular Cataract

Drugs & Therapeutics for Early-Onset Posterior Subcapsular Cataract

Search Clinical Trials , NIH Clinical Center for Early-Onset Posterior Subcapsular Cataract

Genetic Tests for Early-Onset Posterior Subcapsular Cataract

Anatomical Context for Early-Onset Posterior Subcapsular Cataract

MalaCards organs/tissues related to Early-Onset Posterior Subcapsular Cataract:

40
Eye

Publications for Early-Onset Posterior Subcapsular Cataract

Articles related to Early-Onset Posterior Subcapsular Cataract:

# Title Authors PMID Year
1
Efficacy and safety of ropivacaine HCl in peribulbar anaesthesia for cataract surgery in patients with myotonic dystrophy type 1. 61
32904905 2020

Variations for Early-Onset Posterior Subcapsular Cataract

Expression for Early-Onset Posterior Subcapsular Cataract

Search GEO for disease gene expression data for Early-Onset Posterior Subcapsular Cataract.

Pathways for Early-Onset Posterior Subcapsular Cataract

GO Terms for Early-Onset Posterior Subcapsular Cataract

Cellular components related to Early-Onset Posterior Subcapsular Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear envelope GO:0005635 8.62 LEMD2 CHMP4B

Biological processes related to Early-Onset Posterior Subcapsular Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase B signaling GO:0051898 8.96 LEMD2 EPHA2
2 lens development in camera-type eye GO:0002088 8.62 UNC45B CRYBB2

Sources for Early-Onset Posterior Subcapsular Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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