MCID: ERL020
MIFTS: 51

Early-Onset Schizophrenia

Categories: Neuronal diseases, Rare diseases, Genetic diseases, Mental diseases

Aliases & Classifications for Early-Onset Schizophrenia

MalaCards integrated aliases for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 59
Early Onset Schizophrenia 73

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA96369
ICD10 via Orphanet 34 F20.8
UMLS 73 C1656427

Summaries for Early-Onset Schizophrenia

MalaCards based summary : Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to tic disorder and depression. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways/superpathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Circadian entrainment. The drugs Dopamine and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related phenotypes are shRNA abundance <= 50% and behavior/neurological

Related Diseases for Early-Onset Schizophrenia

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 tic disorder 29.9 DRD2 DRD4 HTR2A
2 depression 28.8 BDNF HTR2A HTR3A MAOA SLC6A4
3 schizoaffective disorder 28.4 BDNF COMT DRD2 DRD3 HTR2A SLC6A4
4 anxiety 27.9 BDNF COMT HTR2A HTR3A MAOA SLC6A4
5 gilles de la tourette syndrome 27.3 BDNF COMT DBH DRD2 DRD4 HTR3A
6 autism 26.8 BDNF COMT DRD2 DRD3 DRD4 HTR2A
7 psychotic disorder 25.6 BDNF COMT DRD1 DRD2 DRD3 DRD4
8 obsessive-compulsive disorder 25.3 BDNF COMT DRD1 DRD2 DRD3 DRD4
9 attention deficit-hyperactivity disorder 25.3 BDNF COMT DBH DRD1 DRD2 DRD3
10 schizophrenia 25.2 BDNF COMT DBH DRD1 DRD2 DRD3
11 bipolar disorder 23.9 BDNF COMT DBH DRD1 DRD2 DRD3
12 childhood-onset schizophrenia 11.5
13 alzheimer disease 5 10.7 HTR2A SLC6A4
14 neonatal hypoxic and ischemic brain injury 10.6 BDNF TH
15 drug-induced mental disorder 10.6 DRD2 HTR2A NDUFS4
16 drug psychosis 10.6 DRD2 HTR2A NDUFS4
17 alcoholic psychosis 10.5 DRD2 HTR2A SLC6A4
18 periodic limb movement disorder 10.5 DRD2 HTR2A SLC6A4
19 supranuclear palsy, progressive, 1 10.5 DRD2 NDUFS4 TH
20 bruxism 10.5 DRD2 HTR2A SLC6A4
21 apnea, obstructive sleep 10.4 HTR2A INS TNF
22 traumatic brain injury 10.4 BDNF COMT DRD2
23 dysthymic disorder 10.4 HTR2A MAOA SLC6A4
24 atypical depressive disorder 10.4 MAOA SLC6A4
25 brain injury 10.4 BDNF COMT DRD2
26 segawa syndrome, autosomal recessive 10.4 INS TH
27 hereditary dystonia 10.4 DBH TH
28 sleep apnea 10.4 HTR2A INS TNF
29 alexithymia 10.4 COMT DRD2 SLC6A4
30 phobia, specific 10.3 COMT MAOA
31 heroin dependence 10.3 BDNF DRD2 DRD4
32 postural hypotension 10.3 DBH INS
33 phobic disorder 10.3 COMT MAOA SLC6A4
34 endogenous depression 10.3 BDNF INS MAOA SLC6A4
35 synucleinopathy 10.2 BDNF COMT TH
36 nervous system disease 10.2 BDNF INS TH TNF
37 dystonia 1, torsion, autosomal dominant 10.2 COMT MAOA TH
38 dystonia 11, myoclonic 10.2 DBH DRD2 TH
39 multiple system atrophy 1 10.2 DBH DRD2 TH
40 eating disorder 10.2 BDNF COMT DRD2 SLC6A4
41 migraine with aura 10.1 DBH DRD2 SLC6A4
42 obsessive-compulsive personality disorder 10.1 DRD3 SLC6A4
43 pure autonomic failure 10.1 DBH MAOA TH
44 schizophreniform disorder 10.1 COMT DRD2
45 central nervous system disease 10.1 BDNF TH TNF
46 postpartum depression 10.1 BDNF COMT MAOA SLC6A4
47 anorexia nervosa 10.1 BDNF COMT HTR2A SLC6A4
48 antisocial personality disorder 10.1 COMT DRD2 MAOA SLC6A4
49 tobacco addiction 10.1 COMT DRD2 HTR2A MAOA
50 polysubstance abuse 10.0 COMT DRD2 DRD3

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to Early-Onset Schizophrenia

Symptoms & Phenotypes for Early-Onset Schizophrenia

GenomeRNAi Phenotypes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 COMT DLG1 DRD1 DRD2 DRD3 DRD4

MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.47 SOX10 TH TNF BDNF COMT DBH
2 homeostasis/metabolism MP:0005376 10.36 BDNF COMT DBH DLG1 DRD1 DRD2
3 growth/size/body region MP:0005378 10.32 SOX10 TH TNF BDNF DBH DLG1
4 endocrine/exocrine gland MP:0005379 10.31 INS SLC6A4 SOX10 TH TNF BDNF
5 cardiovascular system MP:0005385 10.3 COMT DBH DNMT3B DRD1 DRD2 DRD3
6 mortality/aging MP:0010768 10.25 BDNF DBH DLG1 DNMT3B DRD1 DRD2
7 nervous system MP:0003631 10.25 BDNF COMT DBH DLG1 DNMT3B DRD1
8 integument MP:0010771 10.17 NDUFS4 SLC6A4 SOX10 TH TNF BDNF
9 digestive/alimentary MP:0005381 10.16 SOX10 TNF BDNF DLG1 DRD1 DRD2
10 adipose tissue MP:0005375 10.02 DBH DRD1 DRD2 DRD3 INS TNF
11 muscle MP:0005369 10.02 DLG1 DRD1 DRD2 HTR2A HTR3A INS
12 no phenotypic analysis MP:0003012 9.86 DRD2 INS SOX10 TH TNF BDNF
13 normal MP:0002873 9.81 BDNF DBH DRD1 DRD2 INS NDUFS4
14 respiratory system MP:0005388 9.61 BDNF COMT DLG1 DRD1 DRD2 NDUFS4
15 vision/eye MP:0005391 9.32 BDNF DBH DLG1 DNMT3B DRD1 DRD4

Drugs & Therapeutics for Early-Onset Schizophrenia

Drugs for Early-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Molindone Approved Phase 4 7416-34-4 23897
5 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
6 Serotonin Agents Phase 4,Phase 3,Phase 2
7 Serotonin Antagonists Phase 4,Phase 3,Phase 2
8 Serotonin Uptake Inhibitors Phase 4
9 Gastrointestinal Agents Phase 4
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
11 Neurotransmitter Uptake Inhibitors Phase 4
12 Tranquilizing Agents Phase 4,Phase 3,Phase 2
13 Dopamine Agents Phase 4,Phase 3,Phase 2
14 Dopamine Antagonists Phase 4,Phase 3,Phase 2
15 Peripheral Nervous System Agents Phase 4
16 Antiemetics Phase 4
17 Antipsychotic Agents Phase 4,Phase 3,Phase 2
18 Psychotropic Drugs Phase 4,Phase 3,Phase 2
19 Autonomic Agents Phase 4
20
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
21
Ziprasidone Approved Phase 3,Phase 2 146939-27-7 60854
22
Diazepam Approved, Illicit, Investigational, Vet_approved 439-14-5 3016
23
Ciprofloxacin Approved, Investigational 85721-33-1 2764
24
Meropenem Approved, Investigational 119478-56-7 64778 441130
25
Warfarin Approved 81-81-2 6691 54678486
26
Alfentanil Approved, Illicit 71195-58-9 51263
27
Heparin Approved, Investigational 9005-49-6 772 46507594
28
Topiramate Approved 97240-79-4 5284627
29
Clozapine Approved 5786-21-0 2818
30
Timolol Approved 26839-75-8 33624 5478
31
Morphine Approved, Investigational 57-27-2 5288826
32
Oseltamivir Approved 204255-11-8, 196618-13-0 65028
33
Cidofovir Approved 113852-37-2 60613
34
Midazolam Approved, Illicit 59467-70-8 4192
35
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
36
Tobramycin Approved, Investigational 32986-56-4 5496 36294
37
Valproic Acid Approved, Investigational 99-66-1 3121
38
Aripiprazole Approved, Investigational 129722-12-9 60795
39
Prednisolone Approved, Vet_approved 50-24-8 5755
40
Pentobarbital Approved, Investigational, Vet_approved 76-74-4 4737
41
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
42
Haloperidol Approved 52-86-8 3559
43
Hydromorphone Approved, Illicit 466-99-9 5284570
44
Fosphenytoin Approved, Investigational 93390-81-9 56339
45
Ceftazidime Approved 78439-06-2, 72558-82-8 5481173
46
Nicardipine Approved, Investigational 55985-32-5 4474
47
Epinephrine Approved, Vet_approved 51-43-4 5816
48
Methylprednisolone Approved, Vet_approved 83-43-2 6741
49
Racepinephrine Approved 329-65-7 838
50 Etiracetam Investigational 33996-58-6

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS) Completed NCT00053703 Phase 4 Risperidone;Olanzapine (enrollment closed in this treatment);Molindone
2 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Olanzapine Plasma Concentration in Treatment of Early-onset Schizophrenia Recruiting NCT02435654 Phase 4 olanzapine
3 Safety And Tolerability Of Ziprasidone In Adolescents With Schizophrenia Terminated NCT00265382 Phase 3 Ziprasidone oral capsules
4 Safety And Efficacy Of Ziprasidone In Adolescents With Schizophrenia Terminated NCT00257192 Phase 3 placebo;Ziprasidone oral capsules
5 Ziprasidone in Early Onset Schizophrenia Spectrum Disorders Completed NCT01006551 Phase 2 Ziprasidone
6 Transcranial Direct Current Stimulation (TDCS) for Auditory Hallucinations in Early Onset Schizophrenia (EOS) Completed NCT02764164 Not Applicable
7 Cognitive Remediation Therapy (CRT) in Adolescents With EOS Completed NCT01701609 Not Applicable
8 Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia Completed NCT01781364 Not Applicable
9 the Phenotypic and Genetic Profile of Patients With Early Onset Schizophrenia Associated With Autism Spectrum Disorder. Recruiting NCT02565524 Not Applicable
10 Reward Processing in Schizophrenia Recruiting NCT03068793
11 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Recruiting NCT01431326 The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

Anatomical Context for Early-Onset Schizophrenia

MalaCards organs/tissues related to Early-Onset Schizophrenia:

41
Brain, Cortex, Testes, Thalamus, Temporal Lobe, Cingulate Cortex, Prefrontal Cortex

Publications for Early-Onset Schizophrenia

Articles related to Early-Onset Schizophrenia:

(show top 50) (show all 226)
# Title Authors Year
1
Associations between cognition and internalizing problems in young adults with early-onset schizophrenia: A 13-year follow-up study. ( 29709790 )
2018
2
Do clinical characteristics predict the cognitive course in early-onset schizophrenia-spectrum disorders? ( 29573345 )
2018
3
Developmental vulnerability to psychosis: Selective aggregation of basic self-disturbance in early onset schizophrenia. ( 29804931 )
2018
4
Predictors and Moderators of Antipsychotic-Related Weight Gain in the Treatment of Early-Onset Schizophrenia Spectrum Disorders Study. ( 29920116 )
2018
5
Very early onset schizophrenia diagnostic challenge and cognitive remediation-A case report. ( 29529420 )
2018
6
Exploration and characterisation of the phenotypic and genetic profiles of patients with early onset schizophrenia associated with autism spectrum disorder and their first-degree relatives: a French multicentre case series study protocol (GenAuDiss). ( 29980548 )
2018
7
Impact of individualized education plans on academic success of youth with early onset schizophrenia. ( 29952742 )
2018
8
Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register. ( 29299680 )
2018
9
The interaction of NOS1AP, DISC1, DAOA, and GSK3B confers susceptibility of early-onset schizophrenia in Chinese Han population. ( 29100974 )
2018
10
Early Onset Schizophrenia Associated With Obsessive-Compulsive Disorder: Clinical Features and Correlates. ( 28976410 )
2017
11
Pharmacotherapy effectiveness for clinical subgroups among children and adolescents with early onset schizophrenia. ( 28370310 )
2017
12
Predictors of treatment response and drop out in the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study. ( 28595147 )
2017
13
Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. ( 28793242 )
2017
14
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
15
Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant. ( 28230711 )
2017
16
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28657177 )
2017
17
Treatment retention of risperidone long-acting injection in patients with early-onset schizophrenia in Japan. ( 28558887 )
2017
18
Clozapine-Induced Microseizures, Orofacial Dyskinesia, and Speech Dysfluency in an Adolescent with Treatment Resistant Early Onset Schizophrenia on Concurrent Lithium Therapy. ( 28835863 )
2017
19
Early-onset schizophrenia: Symptoms and social class of origin. ( 28701088 )
2017
20
Add-on Gabapentin Alleviates Paliperidone-induced Head Tremors and Boosts Antipsychotic Response in Early-Onset Schizophrenia ( 29644812 )
2017
21
Pronounced inhibition-related hypofrontal dysfunction in early-onset schizophrenia as indexed by NoGo-P300 amplitude. ( 28174035 )
2017
22
Clozapine-Related Tachycardia in an Adolescent with Treatment-Resistant Early Onset Schizophrenia. ( 28323458 )
2017
23
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28370311 )
2017
24
Evaluation of white matter structure changes, as assessed in tractography, and cognitive dysfunctions in patients with early onset schizophrenia and their first-degree relatives. ( 28987061 )
2017
25
White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies. ( 27015717 )
2016
26
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. ( 26916502 )
2016
27
Disrupted amplitude of low-frequency fluctuations in antipsychotic-naA^ve adolescents with early-onset schizophrenia. ( 27000303 )
2016
28
Challenges in the Psychopharmacological Management of Very Early-Onset Schizophrenia and Anxiety. ( 27992258 )
2016
29
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. ( 27384868 )
2016
30
Time perception of simultaneous and sequential events in early-onset schizophrenia. ( 27388526 )
2016
31
Altered expression of mRNA profiles in blood of early-onset schizophrenia. ( 26733343 )
2016
32
Gestational length affects neurocognition in early-onset schizophrenia. ( 27474856 )
2016
33
Cortisol and ACTH levels in drug-naive adolescents with first-episode early onset schizophrenia. ( 27804260 )
2016
34
Time to Initiation of Clozapine Treatment in Children and Adolescents with Early-Onset Schizophrenia. ( 27737473 )
2016
35
A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia. ( 26801655 )
2016
36
Atypical antipsychotics in the treatment of early-onset schizophrenia. ( 25897226 )
2015
37
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study. ( 25779033 )
2015
38
Assessing and Treating Early Onset Schizophrenia at Schools. ( 26101010 )
2015
39
Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders. ( 26230626 )
2015
40
Reduced event-related low frequency EEG activity in patients with early onset schizophrenia and their unaffected siblings. ( 25745977 )
2015
41
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. ( 26001923 )
2015
42
Bromocriptine mitigated paliperidone metabolic and neuro-hormonal side effects and improved negative domain in a case of early onset schizophrenia. ( 26573387 )
2015
43
Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia. ( 26484249 )
2015
44
Facial, vocal and cross-modal emotion processing in early-onset schizophrenia spectrum disorders. ( 26297473 )
2015
45
Executive functioning improves after remission of psychosis and may not deteriorate at short follow-up in early-onset schizophrenia. ( 26071585 )
2015
46
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. ( 26440542 )
2015
47
A co-expression network analysis reveals lncRNA abnormalities in peripheral blood in early-onset schizophrenia. ( 25967042 )
2015
48
Early onset schizophrenia: Gender analysis of genome-wide potential methylation. ( 25840049 )
2015
49
Reduced sleep spindle density in early onset schizophrenia: a preliminary finding. ( 25999041 )
2015
50
Comparison of history of adolescents with substance-induced psychosis, early onset schizophrenia and substance use disorders. ( 25520226 )
2014

Variations for Early-Onset Schizophrenia

Expression for Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for Early-Onset Schizophrenia

Pathways related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 BDNF DNMT3B DRD1 DRD2 INS MAOA
2
Show member pathways
12.92 COMT DRD1 DRD2 DRD3 DRD4 MAOA
3
Show member pathways
12.68 BDNF DRD1 DRD2 DRD3 DRD4 INS
4 12.21 DRD1 DRD2 DRD3 DRD4
6 11.9 HTR2A HTR3A MAOA SLC6A4
7
Show member pathways
11.87 BDNF DRD1 DRD2 MAOA TH
8
Show member pathways
11.83 DRD2 DRD3 DRD4 TH
9
Show member pathways
11.83 DRD1 DRD2 DRD3 DRD4 HTR2A
10 11.78 DRD3 DRD4 HTR2A
11 11.72 DBH MAOA TH
12 11.7 DRD1 DRD2 HTR2A
13
Show member pathways
11.66 COMT DBH MAOA TH
14 11.64 BDNF SOX10 TH
15 11.44 BDNF HTR2A HTR3A MAOA SLC6A4 TH
16
Show member pathways
11.13 COMT MAOA SLC6A4
17 11.01 DRD1 DRD2 DRD3
18 11 HTR2A HTR3A MAOA SLC6A4
19
Show member pathways
10.99 DBH MAOA SLC6A4 TH TNF
20
Show member pathways
10.8 COMT DBH MAOA TH
21 10.78 COMT MAOA TH
22
Show member pathways
10.77 COMT MAOA

GO Terms for Early-Onset Schizophrenia

Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.56 DRD1 DRD2 DRD3 DRD4 HTR2A HTR3A
2 dendrite GO:0030425 9.55 BDNF COMT DRD2 HTR2A TH
3 axon GO:0030424 9.1 BDNF COMT DRD2 HTR2A HTR3A TH

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.96 DNMT3B DRD2 SLC6A4 TH
2 response to ethanol GO:0045471 9.93 DRD2 DRD3 HTR3A TH
3 response to drug GO:0042493 9.92 COMT DNMT3B DRD1 DRD2 DRD3 HTR2A
4 locomotory behavior GO:0007626 9.91 DBH DRD1 DRD2 DRD3 TH
5 response to toxic substance GO:0009636 9.9 DNMT3B DRD2 SLC6A4
6 cellular calcium ion homeostasis GO:0006874 9.9 DRD3 DRD4 HTR2A
7 response to estradiol GO:0032355 9.9 DNMT3B SLC6A4 TH
8 response to organic substance GO:0010033 9.9 INS SLC6A4 TNF
9 learning GO:0007612 9.88 COMT DRD1 DRD3 TH
10 synapse assembly GO:0007416 9.86 BDNF DRD1 DRD2
11 social behavior GO:0035176 9.86 DRD3 DRD4 SLC6A4 TH
12 negative regulation of protein kinase B signaling GO:0051898 9.85 DLG1 DRD2 DRD3
13 regulation of protein phosphorylation GO:0001932 9.85 DRD1 NDUFS4 TNF
14 visual learning GO:0008542 9.84 DBH DRD1 DRD2 DRD3
15 associative learning GO:0008306 9.81 DBH DRD1 DRD2
16 arachidonic acid secretion GO:0050482 9.79 DRD2 DRD3 DRD4
17 regulation of dopamine secretion GO:0014059 9.79 DRD2 DRD3 HTR2A
18 temperature homeostasis GO:0001659 9.78 DRD1 DRD2 HTR2A
19 dopamine receptor signaling pathway GO:0007212 9.78 DRD1 DRD2 DRD3 DRD4
20 behavioral response to ethanol GO:0048149 9.77 DBH DRD2 DRD4
21 response to cocaine GO:0042220 9.77 DNMT3B DRD1 DRD2 DRD3 HTR3A
22 prepulse inhibition GO:0060134 9.75 DRD1 DRD2 DRD3
23 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.74 DRD2 DRD3 DRD4
24 negative regulation of lipid catabolic process GO:0050995 9.73 INS TNF
25 regulation of protein secretion GO:0050708 9.73 INS TNF
26 synaptic transmission, dopaminergic GO:0001963 9.73 DRD1 DRD2 DRD3 TH
27 memory GO:0007613 9.73 BDNF DBH DRD1 HTR2A SLC6A4 TH
28 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.72 DRD2 HTR2A
29 positive regulation of renal sodium excretion GO:0035815 9.72 DRD2 DRD3
30 peristalsis GO:0030432 9.72 DLG1 DRD1 DRD2
31 neurotransmitter biosynthetic process GO:0042136 9.71 SLC6A4 TH
32 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.71 DRD1 DRD2
33 negative regulation of voltage-gated calcium channel activity GO:1901386 9.71 DRD2 DRD4
34 grooming behavior GO:0007625 9.71 DRD1 DRD2
35 maternal behavior GO:0042711 9.71 DBH DRD1
36 negative regulation of protein secretion GO:0050709 9.71 DRD2 DRD3 DRD4 INS
37 striatum development GO:0021756 9.7 DRD1 DRD2
38 G-protein coupled receptor internalization GO:0002031 9.7 DRD2 DRD3
39 neurotransmitter catabolic process GO:0042135 9.7 COMT MAOA
40 catecholamine metabolic process GO:0006584 9.7 COMT MAOA
41 dopamine catabolic process GO:0042420 9.7 COMT DBH MAOA
42 regulation of dopamine metabolic process GO:0042053 9.69 DRD1 DRD4
43 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.69 DRD1 DRD3
44 response to salt stress GO:0009651 9.69 TH TNF
45 positive regulation of potassium ion transport GO:0043268 9.68 DLG1 DRD1
46 mating behavior GO:0007617 9.68 DRD1 TH
47 cellular response to nicotine GO:0071316 9.68 TH TNF
48 catecholamine biosynthetic process GO:0042423 9.67 DBH TH
49 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.67 DRD1 DRD2 DRD3
50 norepinephrine biosynthetic process GO:0042421 9.66 DBH TH

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer activity GO:0004871 9.72 DRD1 DRD2 DRD3 DRD4 HTR2A
2 drug binding GO:0008144 9.56 DRD2 DRD3 DRD4 HTR2A
3 monooxygenase activity GO:0004497 9.54 DBH TH YWHAH
4 insulin-like growth factor receptor binding GO:0005159 9.43 INS YWHAH
5 serotonin binding GO:0051378 9.4 HTR2A HTR3A
6 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD2 DRD3 DRD4
7 dopamine neurotransmitter receptor activity GO:0004952 9.26 DRD1 DRD2 DRD3 DRD4
8 dopamine binding GO:0035240 9.02 DRD1 DRD2 DRD3 DRD4 TH

Sources for Early-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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