MCID: ERL020
MIFTS: 45

Early-Onset Schizophrenia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Early-Onset Schizophrenia

MalaCards integrated aliases for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 59
Early Onset Schizophrenia 73

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA96369
ICD10 via Orphanet 34 F20.8
UMLS 73 C1656427

Summaries for Early-Onset Schizophrenia

MalaCards based summary : Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to schizophrenia and anxiety. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways/superpathways are G-Beta Gamma Signaling and Beta-Adrenergic Signaling. Affiliated tissues include cortex, brain and testes, and related phenotypes are behavior/neurological and cellular

Related Diseases for Early-Onset Schizophrenia

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 31.1 BDNF DRD1 DRD2 HTR2A
2 anxiety 29.9 BDNF HTR2A
3 depression 29.8 BDNF HTR2A
4 tic disorder 29.8 DRD2 HTR2A
5 substance-induced psychosis 29.8 DRD2 HTR2A
6 autism 29.7 BDNF DRD2 HTR2A
7 bipolar disorder 29.7 BDNF DRD1 DRD2 HTR2A
8 gilles de la tourette syndrome 29.6 BDNF DRD2
9 obsessive-compulsive disorder 29.5 BDNF DRD1 DRD2 HTR2A
10 psychotic disorder 29.3 BDNF DRD1 DRD2 HTR2A
11 attention deficit-hyperactivity disorder 29.3 BDNF DRD1 DRD2 HTR2A
12 autism spectrum disorder 10.1
13 paranoid schizophrenia 10.0 BDNF HTR2A
14 borderline personality disorder 10.0 BDNF HTR2A
15 mental depression 10.0 BDNF HTR2A
16 endogenous depression 10.0 BDNF HTR2A
17 heroin dependence 10.0 BDNF DRD2
18 traumatic brain injury 10.0 BDNF DRD2
19 brain injury 10.0 BDNF DRD2
20 tardive dyskinesia 10.0 DRD2 HTR2A
21 alcoholic psychosis 10.0 DRD2 HTR2A
22 supranuclear palsy, progressive, 1 10.0 DRD2 NDUFS4
23 periodic limb movement disorder 10.0 DRD2 HTR2A
24 bulimia nervosa 10.0 BDNF HTR2A
25 bruxism 10.0 DRD2 HTR2A
26 substance abuse 10.0 BDNF DRD2
27 megacolon 10.0 DRD2 HTR2A
28 drug dependence 10.0 BDNF DRD2
29 eating disorder 9.9 BDNF DRD2
30 substance dependence 9.9 BDNF DRD2
31 bipolar i disorder 9.9 BDNF DRD1 HTR2A
32 drug-induced mental disorder 9.9 DRD2 HTR2A NDUFS4
33 drug psychosis 9.9 DRD2 HTR2A NDUFS4
34 alzheimer disease 9.9
35 asperger syndrome 9.9
36 periventricular leukomalacia 9.9
37 neuroleptic malignant syndrome 9.9
38 childhood-onset schizophrenia 9.9
39 leukomalacia 9.9
40 tobacco addiction 9.9 DRD2 HTR2A
41 personality disorder 9.8 BDNF DRD2 HTR2A
42 generalized anxiety disorder 9.8 BDNF DRD2 HTR2A
43 post-traumatic stress disorder 9.8 BDNF DRD2 HTR2A
44 schizoaffective disorder 9.8 BDNF DRD2 HTR2A
45 disease of mental health 9.8 BDNF DRD2 HTR2A
46 mood disorder 9.8 BDNF DRD2 HTR2A
47 pathological gambling 9.8 DRD1 DRD2 HTR2A
48 major depressive disorder 9.8 BDNF DRD2 HTR2A
49 anorexia nervosa 9.8 BDNF HTR2A
50 migraine with or without aura 1 9.8 DRD1 DRD2 HTR2A

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to Early-Onset Schizophrenia

Symptoms & Phenotypes for Early-Onset Schizophrenia

MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 BDNF DRD1 DRD2 HTR2A NDUFS4
2 cellular MP:0005384 9.77 BDNF DNMT3B DRD1 DRD2 NDUFS4
3 digestive/alimentary MP:0005381 9.62 BDNF DRD1 DRD2 HTR2A
4 muscle MP:0005369 9.56 DRD1 DRD2 HTR2A NDUFS4
5 nervous system MP:0003631 9.55 BDNF DNMT3B DRD1 DRD2 NDUFS4
6 respiratory system MP:0005388 9.26 BDNF DRD1 DRD2 NDUFS4
7 vision/eye MP:0005391 8.92 BDNF DNMT3B DRD1 NDUFS4

Drugs & Therapeutics for Early-Onset Schizophrenia

Search Clinical Trials , NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

Anatomical Context for Early-Onset Schizophrenia

MalaCards organs/tissues related to Early-Onset Schizophrenia:

41
Cortex, Brain, Testes, Temporal Lobe, Thalamus, Cingulate Cortex, Prefrontal Cortex

Publications for Early-Onset Schizophrenia

Articles related to Early-Onset Schizophrenia:

(show top 50) (show all 234)
# Title Authors Year
1
Associations between cognition and internalizing problems in young adults with early-onset schizophrenia: A 13-year follow-up study. ( 29709790 )
2018
2
Do clinical characteristics predict the cognitive course in early-onset schizophrenia-spectrum disorders? ( 29573345 )
2018
3
Developmental vulnerability to psychosis: Selective aggregation of basic self-disturbance in early onset schizophrenia. ( 29804931 )
2018
4
Predictors and Moderators of Antipsychotic-Related Weight Gain in the Treatment of Early-Onset Schizophrenia Spectrum Disorders Study. ( 29920116 )
2018
5
Very early onset schizophrenia diagnostic challenge and cognitive remediation-A case report. ( 29529420 )
2018
6
Exploration and characterisation of the phenotypic and genetic profiles of patients with early onset schizophrenia associated with autism spectrum disorder and their first-degree relatives: a French multicentre case series study protocol (GenAuDiss). ( 29980548 )
2018
7
Impact of individualized education plans on academic success of youth with early onset schizophrenia. ( 29952742 )
2018
8
Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register. ( 29299680 )
2018
9
The interaction of NOS1AP, DISC1, DAOA, and GSK3B confers susceptibility of early-onset schizophrenia in Chinese Han population. ( 29100974 )
2018
10
Cerebellar volume in early-onset schizophrenia and its association with severity of symptoms. ( 30304968 )
2018
11
Relationship of common variants in CHRNA5 with early-onset schizophrenia and executive function. ( 30366711 )
2018
12
Gender differences in the prevalence, comorbidities and antipsychotic prescription of early-onset schizophrenia: a nationwide population-based study in Taiwan. ( 30382356 )
2018
13
Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study. ( 30472510 )
2018
14
Early Onset Schizophrenia Associated With Obsessive-Compulsive Disorder: Clinical Features and Correlates. ( 28976410 )
2017
15
Pharmacotherapy effectiveness for clinical subgroups among children and adolescents with early onset schizophrenia. ( 28370310 )
2017
16
Predictors of treatment response and drop out in the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study. ( 28595147 )
2017
17
Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. ( 28793242 )
2017
18
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
19
Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant. ( 28230711 )
2017
20
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28657177 )
2017
21
Treatment retention of risperidone long-acting injection in patients with early-onset schizophrenia in Japan. ( 28558887 )
2017
22
Clozapine-Induced Microseizures, Orofacial Dyskinesia, and Speech Dysfluency in an Adolescent with Treatment Resistant Early Onset Schizophrenia on Concurrent Lithium Therapy. ( 28835863 )
2017
23
Early-onset schizophrenia: Symptoms and social class of origin. ( 28701088 )
2017
24
Add-on Gabapentin Alleviates Paliperidone-induced Head Tremors and Boosts Antipsychotic Response in Early-Onset Schizophrenia ( 29644812 )
2017
25
Pronounced inhibition-related hypofrontal dysfunction in early-onset schizophrenia as indexed by NoGo-P300 amplitude. ( 28174035 )
2017
26
Clozapine-Related Tachycardia in an Adolescent with Treatment-Resistant Early Onset Schizophrenia. ( 28323458 )
2017
27
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28370311 )
2017
28
Evaluation of white matter structure changes, as assessed in tractography, and cognitive dysfunctions in patients with early onset schizophrenia and their first-degree relatives. ( 28987061 )
2017
29
White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies. ( 27015717 )
2016
30
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. ( 26916502 )
2016
31
Disrupted amplitude of low-frequency fluctuations in antipsychotic-naA^ve adolescents with early-onset schizophrenia. ( 27000303 )
2016
32
Challenges in the Psychopharmacological Management of Very Early-Onset Schizophrenia and Anxiety. ( 27992258 )
2016
33
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. ( 27384868 )
2016
34
Time perception of simultaneous and sequential events in early-onset schizophrenia. ( 27388526 )
2016
35
Altered expression of mRNA profiles in blood of early-onset schizophrenia. ( 26733343 )
2016
36
Gestational length affects neurocognition in early-onset schizophrenia. ( 27474856 )
2016
37
Cortisol and ACTH levels in drug-naive adolescents with first-episode early onset schizophrenia. ( 27804260 )
2016
38
Time to Initiation of Clozapine Treatment in Children and Adolescents with Early-Onset Schizophrenia. ( 27737473 )
2016
39
A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia. ( 26801655 )
2016
40
Atypical antipsychotics in the treatment of early-onset schizophrenia. ( 25897226 )
2015
41
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study. ( 25779033 )
2015
42
Assessing and Treating Early Onset Schizophrenia at Schools. ( 26101010 )
2015
43
Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders. ( 26230626 )
2015
44
Reduced event-related low frequency EEG activity in patients with early onset schizophrenia and their unaffected siblings. ( 25745977 )
2015
45
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. ( 26001923 )
2015
46
Bromocriptine mitigated paliperidone metabolic and neuro-hormonal side effects and improved negative domain in a case of early onset schizophrenia. ( 26573387 )
2015
47
Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia. ( 26484249 )
2015
48
Facial, vocal and cross-modal emotion processing in early-onset schizophrenia spectrum disorders. ( 26297473 )
2015
49
Executive functioning improves after remission of psychosis and may not deteriorate at short follow-up in early-onset schizophrenia. ( 26071585 )
2015
50
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. ( 26440542 )
2015

Variations for Early-Onset Schizophrenia

Expression for Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for Early-Onset Schizophrenia

GO Terms for Early-Onset Schizophrenia

Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.58 BDNF DRD2 HTR2A
2 axon GO:0030424 9.5 BDNF DRD2 HTR2A
3 GABA-ergic synapse GO:0098982 9.43 DRD1 DRD2
4 glutamatergic synapse GO:0098978 9.43 DRD1 DRD2 HTR2A
5 ciliary membrane GO:0060170 9.37 DRD1 DRD2
6 non-motile cilium GO:0097730 9.16 DRD1 DRD2
7 integral component of presynaptic membrane GO:0099056 9.13 DRD1 DRD2 HTR2A
8 integral component of postsynaptic membrane GO:0099055 8.8 DRD1 DRD2 HTR2A

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.67 DNMT3B DRD1 DRD2 HTR2A
2 response to toxic substance GO:0009636 9.65 DNMT3B DRD2
3 locomotory behavior GO:0007626 9.64 DRD1 DRD2
4 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.64 DRD1 HTR2A
5 modulation of chemical synaptic transmission GO:0050804 9.63 BDNF DRD2
6 regulation of protein phosphorylation GO:0001932 9.63 DRD1 NDUFS4
7 visual learning GO:0008542 9.62 DRD1 DRD2
8 release of sequestered calcium ion into cytosol GO:0051209 9.62 DRD2 HTR2A
9 response to amphetamine GO:0001975 9.61 DRD1 DRD2
10 feeding behavior GO:0007631 9.61 DRD1 DRD2
11 memory GO:0007613 9.61 BDNF DRD1 HTR2A
12 adult walking behavior GO:0007628 9.6 DRD1 DRD2
13 associative learning GO:0008306 9.59 DRD1 DRD2
14 activation of phospholipase C activity GO:0007202 9.58 BDNF HTR2A
15 dopamine receptor signaling pathway GO:0007212 9.58 DRD1 DRD2
16 synaptic transmission, dopaminergic GO:0001963 9.57 DRD1 DRD2
17 striatum development GO:0021756 9.56 DRD1 DRD2
18 dopamine metabolic process GO:0042417 9.55 DRD1 DRD2
19 prepulse inhibition GO:0060134 9.54 DRD1 DRD2
20 grooming behavior GO:0007625 9.52 DRD1 DRD2
21 peristalsis GO:0030432 9.51 DRD1 DRD2
22 synapse assembly GO:0007416 9.5 BDNF DRD1 DRD2
23 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.49 DRD2 HTR2A
24 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.48 DRD1 DRD2
25 cerebral cortex GABAergic interneuron migration GO:0021853 9.46 DRD1 DRD2
26 regulation of synaptic vesicle exocytosis GO:2000300 9.43 DRD1 DRD2 HTR2A
27 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.4 DRD1 DRD2
28 response to cocaine GO:0042220 9.33 DNMT3B DRD1 DRD2
29 temperature homeostasis GO:0001659 9.13 DRD1 DRD2 HTR2A
30 behavioral response to cocaine GO:0048148 8.8 DRD1 DRD2 HTR2A

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.26 DRD2 HTR2A
2 G-protein alpha-subunit binding GO:0001965 9.16 DRD1 HTR2A
3 dopamine binding GO:0035240 8.96 DRD1 DRD2
4 dopamine neurotransmitter receptor activity GO:0004952 8.62 DRD1 DRD2

Sources for Early-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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