MCID: ERL020
MIFTS: 40

Early-Onset Schizophrenia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Early-Onset Schizophrenia

MalaCards integrated aliases for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 60
Early Onset Schizophrenia 74

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 F20.8
Orphanet 60 ORPHA96369
UMLS 74 C1656427

Summaries for Early-Onset Schizophrenia

MalaCards based summary : Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to schizophrenia and anxiety. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways/superpathways are G-Beta Gamma Signaling and Beta-Adrenergic Signaling. Affiliated tissues include brain, cortex and testes, and related phenotypes are behavior/neurological and cellular

Related Diseases for Early-Onset Schizophrenia

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 30.5 BDNF DRD1 DRD2 HTR2A
2 anxiety 30.0 BDNF HTR2A
3 depression 29.9 BDNF HTR2A
4 bipolar disorder 29.8 BDNF DRD2 HTR2A
5 tic disorder 29.7 DRD2 HTR2A
6 substance-induced psychosis 29.6 DRD2 HTR2A
7 gilles de la tourette syndrome 29.4 BDNF DRD2
8 obsessive-compulsive disorder 29.0 BDNF DRD1 DRD2 HTR2A
9 psychotic disorder 28.8 BDNF DRD1 DRD2 HTR2A
10 attention deficit-hyperactivity disorder 28.7 BDNF DRD1 DRD2 HTR2A
11 childhood-onset schizophrenia 11.7
12 autism 10.1
13 autism spectrum disorder 10.1
14 paranoid schizophrenia 10.1 BDNF HTR2A
15 borderline personality disorder 10.1 BDNF HTR2A
16 mental depression 10.0 BDNF HTR2A
17 endogenous depression 10.0 BDNF HTR2A
18 bulimia nervosa 10.0 BDNF HTR2A
19 heroin dependence 9.9 BDNF DRD2
20 traumatic brain injury 9.9 BDNF DRD2
21 brain injury 9.9 BDNF DRD2
22 tardive dyskinesia 9.9 DRD2 HTR2A
23 alcoholic psychosis 9.9 DRD2 HTR2A
24 periodic limb movement disorder 9.9 DRD2 HTR2A
25 alzheimer disease 9.9
26 pol iii-related leukodystrophies 9.9
27 asperger syndrome 9.9
28 periventricular leukomalacia 9.9
29 neuroleptic malignant syndrome 9.9
30 lingual-facial-buccal dyskinesia 9.9
31 leukomalacia 9.9
32 tremor 9.9
33 bruxism 9.9 DRD2 HTR2A
34 substance abuse 9.8 BDNF DRD2
35 drug dependence 9.8 BDNF DRD2
36 anorexia nervosa 9.8 BDNF HTR2A
37 megacolon 9.8 DRD2 HTR2A
38 eating disorder 9.8 BDNF DRD2
39 substance dependence 9.8 BDNF DRD2
40 bipolar i disorder 9.8 BDNF DRD1 HTR2A
41 tobacco addiction 9.7 DRD2 HTR2A
42 drug-induced mental disorder 9.7 DRD2 HTR2A NDUFS4
43 drug psychosis 9.7 DRD2 HTR2A NDUFS4
44 personality disorder 9.6 BDNF DRD2 HTR2A
45 generalized anxiety disorder 9.6 BDNF DRD2 HTR2A
46 post-traumatic stress disorder 9.6 BDNF DRD2 HTR2A
47 schizoaffective disorder 9.6 BDNF DRD2 HTR2A
48 disease of mental health 9.6 BDNF DRD2 HTR2A
49 mood disorder 9.6 BDNF DRD2 HTR2A
50 major depressive disorder 9.6 BDNF DRD2 HTR2A

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to Early-Onset Schizophrenia

Symptoms & Phenotypes for Early-Onset Schizophrenia

MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 BDNF DRD1 DRD2 HTR2A NDUFS4
2 cellular MP:0005384 9.77 BDNF DNMT3B DRD1 DRD2 NDUFS4
3 digestive/alimentary MP:0005381 9.62 BDNF DRD1 DRD2 HTR2A
4 muscle MP:0005369 9.56 DRD1 DRD2 HTR2A NDUFS4
5 nervous system MP:0003631 9.55 BDNF DNMT3B DRD1 DRD2 NDUFS4
6 respiratory system MP:0005388 9.26 BDNF DRD1 DRD2 NDUFS4
7 vision/eye MP:0005391 8.92 BDNF DNMT3B DRD1 NDUFS4

Drugs & Therapeutics for Early-Onset Schizophrenia

Search Clinical Trials , NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

Anatomical Context for Early-Onset Schizophrenia

MalaCards organs/tissues related to Early-Onset Schizophrenia:

42
Brain, Cortex, Testes, Temporal Lobe, Thalamus, Cingulate Cortex, Prefrontal Cortex

Publications for Early-Onset Schizophrenia

Articles related to Early-Onset Schizophrenia:

(show top 50) (show all 238)
# Title Authors Year
1
Distinguishing prodromal stage of bipolar disorder and early onset schizophrenia spectrum disorders during adolescence. ( 30953877 )
2019
2
Cerebellar volume in early-onset schizophrenia and its association with severity of symptoms. ( 30304968 )
2019
3
Relationship of common variants in CHRNA5 with early-onset schizophrenia and executive function. ( 30366711 )
2019
4
Altered dynamic global signal topography in antipsychotic-naive adolescents with early-onset schizophrenia. ( 30772067 )
2019
5
GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function. ( 30785307 )
2019
6
Exploration and characterisation of the phenotypic and genetic profiles of patients with early onset schizophrenia associated with autism spectrum disorder and their first-degree relatives: a French multicentre case series study protocol (GenAuDiss). ( 29980548 )
2018
7
The interaction of NOS1AP, DISC1, DAOA, and GSK3B confers susceptibility of early-onset schizophrenia in Chinese Han population. ( 29100974 )
2018
8
Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register. ( 29299680 )
2018
9
Very early onset schizophrenia diagnostic challenge and cognitive remediation-A case report. ( 29529420 )
2018
10
Do clinical characteristics predict the cognitive course in early-onset schizophrenia-spectrum disorders? ( 29573345 )
2018
11
Associations between cognition and internalizing problems in young adults with early-onset schizophrenia: A 13-year follow-up study. ( 29709790 )
2018
12
Developmental vulnerability to psychosis: Selective aggregation of basic self-disturbance in early onset schizophrenia. ( 29804931 )
2018
13
Predictors and Moderators of Antipsychotic-Related Weight Gain in the Treatment of Early-Onset Schizophrenia Spectrum Disorders Study. ( 29920116 )
2018
14
Impact of individualized education plans on academic success of youth with early onset schizophrenia. ( 29952742 )
2018
15
Gender differences in the prevalence, comorbidities and antipsychotic prescription of early-onset schizophrenia: a nationwide population-based study in Taiwan. ( 30382356 )
2018
16
Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study. ( 30472510 )
2018
17
Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant. ( 28230711 )
2017
18
Cortisol and ACTH levels in drug-naive adolescents with first-episode early onset schizophrenia. ( 27804260 )
2017
19
Pronounced inhibition-related hypofrontal dysfunction in early-onset schizophrenia as indexed by NoGo-P300 amplitude. ( 28174035 )
2017
20
Clozapine-Related Tachycardia in an Adolescent with Treatment-Resistant Early Onset Schizophrenia. ( 28323458 )
2017
21
Pharmacotherapy effectiveness for clinical subgroups among children and adolescents with early onset schizophrenia. ( 28370310 )
2017
22
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28370311 )
2017
23
Treatment retention of risperidone long-acting injection in patients with early-onset schizophrenia in Japan. ( 28558887 )
2017
24
Predictors of treatment response and drop out in the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study. ( 28595147 )
2017
25
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28657177 )
2017
26
Early-onset schizophrenia: Symptoms and social class of origin. ( 28701088 )
2017
27
Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. ( 28793242 )
2017
28
Clozapine-Induced Microseizures, Orofacial Dyskinesia, and Speech Dysfluency in an Adolescent with Treatment Resistant Early Onset Schizophrenia on Concurrent Lithium Therapy. ( 28835863 )
2017
29
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
30
Early Onset Schizophrenia Associated With Obsessive-Compulsive Disorder: Clinical Features and Correlates. ( 28976410 )
2017
31
Evaluation of white matter structure changes, as assessed in tractography, and cognitive dysfunctions in patients with early onset schizophrenia and their first-degree relatives. ( 28987061 )
2017
32
Add-on Gabapentin Alleviates Paliperidone-induced Head Tremors and Boosts Antipsychotic Response in Early-Onset Schizophrenia ( 29644812 )
2017
33
Bromocriptine mitigated paliperidone metabolic and neuro-hormonal side effects and improved negative domain in a case of early onset schizophrenia. ( 26573387 )
2016
34
Altered expression of mRNA profiles in blood of early-onset schizophrenia. ( 26733343 )
2016
35
A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia. ( 26801655 )
2016
36
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. ( 26916502 )
2016
37
Disrupted amplitude of low-frequency fluctuations in antipsychotic-naïve adolescents with early-onset schizophrenia. ( 27000303 )
2016
38
White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies. ( 27015717 )
2016
39
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. ( 27384868 )
2016
40
Time perception of simultaneous and sequential events in early-onset schizophrenia. ( 27388526 )
2016
41
Gestational length affects neurocognition in early-onset schizophrenia. ( 27474856 )
2016
42
Time to Initiation of Clozapine Treatment in Children and Adolescents with Early-Onset Schizophrenia. ( 27737473 )
2016
43
Challenges in the Psychopharmacological Management of Very Early-Onset Schizophrenia and Anxiety. ( 27992258 )
2016
44
Homotopic connectivity in drug-naïve, first-episode, early-onset schizophrenia. ( 25130214 )
2015
45
Reduced event-related low frequency EEG activity in patients with early onset schizophrenia and their unaffected siblings. ( 25745977 )
2015
46
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study. ( 25779033 )
2015
47
Early onset schizophrenia: Gender analysis of genome-wide potential methylation. ( 25840049 )
2015
48
Atypical antipsychotics in the treatment of early-onset schizophrenia. ( 25897226 )
2015
49
A co-expression network analysis reveals lncRNA abnormalities in peripheral blood in early-onset schizophrenia. ( 25967042 )
2015
50
Reduced sleep spindle density in early onset schizophrenia: a preliminary finding. ( 25999041 )
2015

Variations for Early-Onset Schizophrenia

Expression for Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for Early-Onset Schizophrenia

GO Terms for Early-Onset Schizophrenia

Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.58 BDNF DRD2 HTR2A
2 axon GO:0030424 9.5 BDNF DRD2 HTR2A
3 GABA-ergic synapse GO:0098982 9.43 DRD1 DRD2
4 glutamatergic synapse GO:0098978 9.43 DRD1 DRD2 HTR2A
5 ciliary membrane GO:0060170 9.37 DRD1 DRD2
6 non-motile cilium GO:0097730 9.16 DRD1 DRD2
7 integral component of presynaptic membrane GO:0099056 9.13 DRD1 DRD2 HTR2A
8 integral component of postsynaptic membrane GO:0099055 8.8 DRD1 DRD2 HTR2A

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.67 DNMT3B DRD1 DRD2 HTR2A
2 response to toxic substance GO:0009636 9.65 DNMT3B DRD2
3 locomotory behavior GO:0007626 9.64 DRD1 DRD2
4 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.64 DRD1 HTR2A
5 modulation of chemical synaptic transmission GO:0050804 9.63 BDNF DRD2
6 regulation of protein phosphorylation GO:0001932 9.63 DRD1 NDUFS4
7 visual learning GO:0008542 9.62 DRD1 DRD2
8 release of sequestered calcium ion into cytosol GO:0051209 9.62 DRD2 HTR2A
9 response to amphetamine GO:0001975 9.61 DRD1 DRD2
10 feeding behavior GO:0007631 9.61 DRD1 DRD2
11 memory GO:0007613 9.61 BDNF DRD1 HTR2A
12 adult walking behavior GO:0007628 9.6 DRD1 DRD2
13 associative learning GO:0008306 9.59 DRD1 DRD2
14 activation of phospholipase C activity GO:0007202 9.58 BDNF HTR2A
15 dopamine receptor signaling pathway GO:0007212 9.58 DRD1 DRD2
16 synaptic transmission, dopaminergic GO:0001963 9.57 DRD1 DRD2
17 striatum development GO:0021756 9.56 DRD1 DRD2
18 dopamine metabolic process GO:0042417 9.55 DRD1 DRD2
19 prepulse inhibition GO:0060134 9.54 DRD1 DRD2
20 grooming behavior GO:0007625 9.52 DRD1 DRD2
21 peristalsis GO:0030432 9.51 DRD1 DRD2
22 synapse assembly GO:0007416 9.5 BDNF DRD1 DRD2
23 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.49 DRD2 HTR2A
24 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.48 DRD1 DRD2
25 cerebral cortex GABAergic interneuron migration GO:0021853 9.46 DRD1 DRD2
26 regulation of synaptic vesicle exocytosis GO:2000300 9.43 DRD1 DRD2 HTR2A
27 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.4 DRD1 DRD2
28 response to cocaine GO:0042220 9.33 DNMT3B DRD1 DRD2
29 temperature homeostasis GO:0001659 9.13 DRD1 DRD2 HTR2A
30 behavioral response to cocaine GO:0048148 8.8 DRD1 DRD2 HTR2A

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.26 DRD2 HTR2A
2 G-protein alpha-subunit binding GO:0001965 9.16 DRD1 HTR2A
3 dopamine binding GO:0035240 8.96 DRD1 DRD2
4 dopamine neurotransmitter receptor activity GO:0004952 8.62 DRD1 DRD2

Sources for Early-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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