MCID: ERL020
MIFTS: 43

Early-Onset Schizophrenia

Categories: Ear diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Early-Onset Schizophrenia

Summaries for Early-Onset Schizophrenia

MalaCards based summary : Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to schizophrenia and schizoaffective disorder. An important gene associated with Early-Onset Schizophrenia is YWHAH (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta), and among its related pathways/superpathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Prion disease. The drugs Olanzapine and Psychotropic Drugs have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and temporal lobe, and related phenotypes are psychosis and emotional lability

Related Diseases for Early-Onset Schizophrenia

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 30.5 YWHAH DRD2 DRD1 BDNF
2 schizoaffective disorder 30.1 DRD2 BDNF
3 mental depression 29.9 DRD2 BDNF
4 personality disorder 29.9 DRD2 BDNF
5 psychotic disorder 29.8 DRD2 DRD1 BDNF
6 attention deficit-hyperactivity disorder 29.7 DRD2 DRD1 BDNF
7 schizophreniform disorder 29.6 DRD2 BDNF
8 substance abuse 29.6 DRD2 BDNF
9 endogenous depression 29.5 DRD2 BDNF
10 bipolar disorder 29.5 YWHAH DRD2 DRD1 BDNF
11 tic disorder 29.5 DRD2 DRD1
12 oppositional defiant disorder 29.5 DRD2 DRD1
13 obsessive-compulsive disorder 29.3 DRD2 DRD1 BDNF
14 mood disorder 29.2 DRD2 DNMT3B BDNF
15 major depressive disorder 29.2 DRD2 DRD1 BDNF
16 gilles de la tourette syndrome 29.1 DRD2 DRD1 BDNF
17 migraine with or without aura 1 29.1 DRD2 DRD1 BDNF
18 alcohol dependence 29.0 DRD2 DRD1 BDNF
19 childhood-onset schizophrenia 11.1
20 major affective disorder 8 10.4
21 major affective disorder 9 10.4
22 autism spectrum disorder 10.3
23 autism 10.3
24 agenesis of corpus callosum, cardiac, ocular, and genital syndrome 10.2
25 granulocytopenia 10.2
26 depression 10.2
27 hand skill, relative 10.1
28 tardive dyskinesia 10.1
29 alacrima, achalasia, and mental retardation syndrome 10.1
30 schizotypal personality disorder 10.1
31 neutropenia 10.1
32 avoidant personality disorder 10.0
33 tremor 10.0
34 hypertriglyceridemia, familial 9.9
35 schizophrenia 1 9.9
36 velocardiofacial syndrome 9.9
37 fragile x syndrome 9.9
38 corpus callosum, partial agenesis of, x-linked 9.9
39 rett syndrome 9.9
40 schizophrenia 3 9.9
41 schizophrenia 4 9.9
42 schizophrenia 6 9.9
43 schizophrenia 10 9.9
44 anxiety 9.9
45 hyperprolactinemia 9.9
46 carbonic anhydrase va deficiency, hyperammonemia due to 9.9
47 corpus callosum, agenesis of, with facial anomalies and cerebellar ataxia 9.9
48 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.9
49 asperger syndrome 9.9
50 pervasive developmental disorder 9.9

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to Early-Onset Schizophrenia

Symptoms & Phenotypes for Early-Onset Schizophrenia

Human phenotypes related to Early-Onset Schizophrenia:

58 31 (show all 43)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 psychosis 58 31 obligate (100%) Obligate (100%) HP:0000709
2 emotional lability 58 31 frequent (33%) Frequent (79-30%) HP:0000712
3 depressivity 58 31 frequent (33%) Frequent (79-30%) HP:0000716
4 cognitive impairment 58 31 frequent (33%) Frequent (79-30%) HP:0100543
5 autism 58 31 frequent (33%) Frequent (79-30%) HP:0000717
6 anxiety 58 31 frequent (33%) Frequent (79-30%) HP:0000739
7 specific learning disability 58 31 frequent (33%) Frequent (79-30%) HP:0001328
8 irritability 58 31 frequent (33%) Frequent (79-30%) HP:0000737
9 confusion 58 31 frequent (33%) Frequent (79-30%) HP:0001289
10 language impairment 58 31 frequent (33%) Frequent (79-30%) HP:0002463
11 no social interaction 58 31 frequent (33%) Frequent (79-30%) HP:0008763
12 mood changes 58 31 frequent (33%) Frequent (79-30%) HP:0001575
13 lack of peer relationships 58 31 frequent (33%) Frequent (79-30%) HP:0002332
14 low self esteem 58 31 frequent (33%) Frequent (79-30%) HP:0031469
15 addictive behavior 58 31 frequent (33%) Frequent (79-30%) HP:0030858
16 attention deficit hyperactivity disorder 58 31 occasional (7.5%) Occasional (29-5%) HP:0007018
17 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
18 obsessive-compulsive behavior 58 31 occasional (7.5%) Occasional (29-5%) HP:0000722
19 restlessness 58 31 occasional (7.5%) Occasional (29-5%) HP:0000711
20 abnormal temper tantrums 58 31 occasional (7.5%) Occasional (29-5%) HP:0025160
21 visual hallucinations 58 31 occasional (7.5%) Occasional (29-5%) HP:0002367
22 personality changes 58 31 occasional (7.5%) Occasional (29-5%) HP:0000751
23 polyphagia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002591
24 paranoia 58 31 occasional (7.5%) Occasional (29-5%) HP:0011999
25 shyness 58 31 occasional (7.5%) Occasional (29-5%) HP:0100962
26 oppositional defiant disorder 58 31 occasional (7.5%) Occasional (29-5%) HP:0010865
27 diminished motivation 58 31 occasional (7.5%) Occasional (29-5%) HP:0000745
28 anhedonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0012154
29 sleep onset insomnia 58 31 occasional (7.5%) Occasional (29-5%) HP:0031354
30 unhappy demeanor 58 31 occasional (7.5%) Occasional (29-5%) HP:0031588
31 suicidal ideation 58 31 occasional (7.5%) Occasional (29-5%) HP:0031589
32 hypersomnia 58 31 very rare (1%) Very rare (<4-1%) HP:0100786
33 auditory hallucinations 58 31 very rare (1%) Very rare (<4-1%) HP:0008765
34 decreased female libido 58 31 very rare (1%) Very rare (<4-1%) HP:0030018
35 decreased male libido 58 31 very rare (1%) Very rare (<4-1%) HP:0040306
36 mania 58 31 very rare (1%) Very rare (<4-1%) HP:0100754
37 behavioral abnormality 58 Frequent (79-30%)
38 hallucinations 58 Frequent (79-30%)
39 autistic behavior 58 Frequent (79-30%)
40 short attention span 58 Frequent (79-30%)
41 abnormal emotion/affect behavior 58 Occasional (29-5%)
42 delusions 58 Frequent (79-30%)
43 impairment in personality functioning 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 BDNF DNMT3B DRD1 DRD2 NDUFS4
2 respiratory system MP:0005388 8.92 BDNF DRD1 DRD2 NDUFS4

Drugs & Therapeutics for Early-Onset Schizophrenia

Drugs for Early-Onset Schizophrenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585 135398745
2 Psychotropic Drugs Phase 4
3 Gastrointestinal Agents Phase 4
4 Antiemetics Phase 4
5 Serotonin Uptake Inhibitors Phase 4
6 Antipsychotic Agents Phase 4
7 Neurotransmitter Agents Phase 4
8
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
9
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
10
Ziprasidone Approved Phase 2 146939-27-7 60854
11 Dopamine Agents Phase 2
12 Dopamine Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of 5-HTR2A, DRD2,and COMT Genes Polymorphisms and Drug Plasma Concentration on Antipsychotic Response to Olanzapine in Treatment of Early-onset Schizophrenia Completed NCT02435654 Phase 4 olanzapine
2 Ziprasidone in Early Onset Schizophrenia Spectrum Disorders Completed NCT01006551 Phase 2 Ziprasidone
3 Efficacy of a Cognitive Remediation Treatment in Adolescents With Schizophrenia Spectrum Disorders Completed NCT01701609
4 Multimodal Neural Investigation of Reward Processing in Mental Illness Completed NCT03068793
5 Exploration and Characterization of the Phenotypic and Genetic Profile of Patients With Early Onset Schizophrenia Associated With Autism Spectrum Disorder and Their First-degree Relatives (GenAuDiss). Recruiting NCT02565524
6 Transcranial Direct Current Stimulation for Auditory Hallucinations in Early Onset Schizophrenia Terminated NCT02764164

Search NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

Anatomical Context for Early-Onset Schizophrenia

MalaCards organs/tissues related to Early-Onset Schizophrenia:

40
Cortex, Brain, Temporal Lobe, Prefrontal Cortex, Cingulate Cortex, Amygdala, Eye

Publications for Early-Onset Schizophrenia

Articles related to Early-Onset Schizophrenia:

(show top 50) (show all 534)
# Title Authors PMID Year
1
Abnormal Thalamocortical Circuit in Adolescents With Early-Onset Schizophrenia. 61
32791099 2021
2
A Neurodevelopment Approach for a Transitional Model of Early Onset Schizophrenia. 61
33672396 2021
3
Time to Clinical Response in the Treatment of Early Onset Schizophrenia Spectrum Disorders Study. 61
32633541 2021
4
Comparison of clinical characteristics and treatment efficacy in childhood-onset schizophrenia and adolescent-onset schizophrenia in mainland China: A retrospective study. 61
33465837 2021
5
Abnormal functional connectivity based on nodes of the default mode network in first-episode drug-naive early-onset schizophrenia. 61
33243520 2021
6
Analysis of the status of drug treatment in 746 inpatients with early-onset schizophrenia in China: a retrospective study. 61
33413200 2021
7
Advantageous Add-on Duloxetine to Aripiprazole-Responsive Early-Onset Schizophrenia. 61
33347030 2021
8
Self-reported sensory responsiveness patterns in typically-developing and early-onset schizophrenia adolescents: Its relationship with schizotypal and autistic traits. 61
33035958 2020
9
[Pharmaco-resistance and side effects of antipsychotics associated with poor metabolizer phenotype for cytochrome P450 2D6 in a context of early-onset schizophrenia: A case report]. 61
32273136 2020
10
Predictive factors in early onset schizophrenia. 61
33149774 2020
11
Lack of Resources for Aftercare for Children With Psychosis: A System's Failure. 61
33489494 2020
12
Subjective health-related quality of life in community-dwelling middle-aged and older adults with early-onset schizophrenia. 61
32513037 2020
13
The Gene Polymorphism of VMAT2 Is Associated with Risk of Schizophrenia in Male Han Chinese. 61
33099987 2020
14
Clozapine: An Updated Overview of Pharmacogenetic Biomarkers, Risks, and Safety-Particularities in the Context of COVID-19. 61
33187329 2020
15
Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naïve schizophrenia. 61
33058544 2020
16
Altered empathy-related resting-state functional connectivity in adolescents with early-onset schizophrenia and autism spectrum disorders. 61
32474345 2020
17
Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium. 61
33017498 2020
18
Emotional Education in Early Onset Schizophrenia and Asperger's Syndrome. 61
32872431 2020
19
Recovery and Recovering in Older Adults with Schizophrenia: A 5-Tier Model. 61
32312650 2020
20
Reduced blood agmatine level in early-onset schizophrenia. 61
32446703 2020
21
Assessment of Similarity in Antipsychotic Exposure-Response Relationships in Clinical Trials Between Adults and Adolescents With Acute Exacerbation of Schizophrenia. 61
31994186 2020
22
Reduced sleep spindle density in adolescent patients with early-onset schizophrenia compared to major depressive disorder and healthy controls. 61
31924372 2020
23
Sex differences in circulating neuregulin1-β1 and β-secretase 1 expression in childhood-onset schizophrenia. 61
32430144 2020
24
Cognitive Brain Signatures of Youth With Early Onset and Relatives With Schizophrenia: Evidence From fMRI Meta-analyses. 61
31978222 2020
25
Long-term outcome of early-onset compared to adult-onset schizophrenia: A nationwide Danish register study. 61
32299717 2020
26
Similar impairments shown on a neuropsychological test battery in adolescents with high-functioning autism and early onset schizophrenia: a two-year follow-up study. 61
31931670 2020
27
Perinatal complications and executive dysfunction in early-onset schizophrenia. 61
32131788 2020
28
Do young adolescents with first-episode psychosis or ADHD show sensorimotor gating deficits? 61
30873927 2020
29
Early- Versus Adult-Onset Schizophrenia as a Predictor of Response to Neuroscience-Informed Cognitive Training. 61
32141724 2020
30
Predictors of outcome in early onset schizophrenia: a 10-year follow-up study. 61
32059664 2020
31
Add-on mirtazapine to clozapine-responsive early-onset schizophrenia. 61
31791706 2020
32
Early and very early-onset schizophrenia compared with adult-onset schizophrenia: French FACE-SZ database. 61
31908151 2020
33
Cognitive Performance in Early-Onset Schizophrenia and Attention-Deficit/Hyperactivity Disorder: A 25-Year Follow-Up Study. 61
33519613 2020
34
CNVs and Chromosomal Aneuploidy in Patients With Early-Onset Schizophrenia and Bipolar Disorder: Genotype-Phenotype Associations. 61
33510659 2020
35
Early-Onset Schizophrenia Showed Similar but More Severe Olfactory Identification Impairment Than Adult-Onset Schizophrenia. 61
32695034 2020
36
Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update. 61
31708054 2020
37
Alterations of plasma cytokine biomarkers for identifying age at onset of schizophrenia with neurological soft signs. 61
32038109 2020
38
Dynamic Alterations of Amplitude of Low-Frequency Fluctuations in Patients With Drug-Naïve First-Episode Early Onset Schizophrenia. 61
33122982 2020
39
Cognition, Social Cognition, and Functional Capacity in Early-Onset Schizophrenia. 61
31708046 2020
40
The Effects of Combined Social Cognition and Interaction Training and Paliperidone on Early-Onset Schizophrenia. 61
33192646 2020
41
Early-Onset Schizophrenia With Predominantly Negative Symptoms: A Case Study of a Drug-Naive Female Patient Treated With Cariprazine. 61
32390838 2020
42
Early-Onset Schizophrenia in a paediatric population of French psychiatric and medico-social care centres: A cross sectional study. 61
32716957 2020
43
Targeted next-generation sequencing identifies the disruption of the SHANK3 and RYR2 genes in a patient carrying a de novo t(1;22)(q43;q13.3) associated with signs of Phelan-McDermid syndrome. 61
32536973 2020
44
The association between early-onset schizophrenia with employment, income, education, and cohabitation status: nationwide study with 35 years of follow-up. 61
31456027 2019
45
Betahistine-Associated Weight Loss and Improved Cognitive and Negative Symptoms: Domain in Early-Onset Schizophrenia. 61
31206362 2019
46
A Quantitative Justification of Similarity in Placebo Response Between Adults and Adolescents With Acute Exacerbation of Schizophrenia in Clinical Trials. 61
31069784 2019
47
Risk Model Assessment in Early-Onset and Adult-Onset Schizophrenia Using Neurological Soft Signs. 61
31514416 2019
48
Altered dynamic global signal topography in antipsychotic-naive adolescents with early-onset schizophrenia. 61
30772067 2019
49
Gender differences in the prevalence, comorbidities and antipsychotic prescription of early-onset schizophrenia: a nationwide population-based study in Taiwan. 61
30382356 2019
50
Distinguishing prodromal stage of bipolar disorder and early onset schizophrenia spectrum disorders during adolescence. 61
30953877 2019

Variations for Early-Onset Schizophrenia

Expression for Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for Early-Onset Schizophrenia

Pathways related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 YWHAH DRD2 DRD1 DNMT3B BDNF
2
Show member pathways
12.26 NDUFS4 DRD2 DRD1
3
Show member pathways
11.95 YWHAH DRD2 DRD1 BDNF
4 11.67 DRD2 DRD1 BDNF
5
Show member pathways
11.5 DRD2 DRD1
6
Show member pathways
11.47 DRD2 DRD1
7 11.35 DRD2 DRD1
8
Show member pathways
10.87 DRD2 DRD1 BDNF
9
Show member pathways
10.62 DRD2 DRD1

GO Terms for Early-Onset Schizophrenia

Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.33 DRD2 DRD1 BDNF
2 ciliary membrane GO:0060170 8.96 DRD2 DRD1
3 non-motile cilium GO:0097730 8.62 DRD2 DRD1

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.71 DRD2 DRD1 DNMT3B
2 response to toxic substance GO:0009636 9.58 DRD2 DNMT3B
3 modulation of chemical synaptic transmission GO:0050804 9.57 DRD2 BDNF
4 visual learning GO:0008542 9.56 DRD2 DRD1
5 response to cocaine GO:0042220 9.55 DRD2 DNMT3B
6 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.52 DRD2 DRD1
7 regulation of neuron differentiation GO:0045664 9.51 YWHAH BDNF
8 adult walking behavior GO:0007628 9.49 DRD2 DRD1
9 dopamine receptor signaling pathway GO:0007212 9.48 DRD2 DRD1
10 regulation of sodium ion transport GO:0002028 9.46 YWHAH DRD2
11 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.43 DRD2 DRD1
12 dopamine metabolic process GO:0042417 9.4 DRD2 DRD1
13 prepulse inhibition GO:0060134 9.37 DRD2 DRD1
14 synaptic transmission, dopaminergic GO:0001963 9.32 DRD2 DRD1
15 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.26 DRD2 DRD1
16 cerebral cortex GABAergic interneuron migration GO:0021853 9.16 DRD2 DRD1
17 regulation of dopamine uptake involved in synaptic transmission GO:0051584 8.96 DRD2 DRD1
18 synapse assembly GO:0007416 8.8 DRD2 DRD1 BDNF

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dopamine binding GO:0035240 8.96 DRD2 DRD1
2 dopamine neurotransmitter receptor activity GO:0004952 8.62 DRD2 DRD1

Sources for Early-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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