MCID: ERL020
MIFTS: 38

Early-Onset Schizophrenia

Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Early-Onset Schizophrenia

MalaCards integrated aliases for Early-Onset Schizophrenia:

Name: Early-Onset Schizophrenia 60
Early Onset Schizophrenia 74

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 F20.8
Orphanet 60 ORPHA96369
UMLS 74 C1656427

Summaries for Early-Onset Schizophrenia

MalaCards based summary : Early-Onset Schizophrenia, also known as early onset schizophrenia, is related to depression and anxiety. An important gene associated with Early-Onset Schizophrenia is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Beta-Adrenergic Signaling. Affiliated tissues include brain, cortex and testes, and related phenotypes are behavior/neurological and cellular

Related Diseases for Early-Onset Schizophrenia

Diseases in the Schizophrenia family:

Schizophrenia 1 Schizophrenia 3
Schizophrenia 4 Schizophrenia 6
Schizophrenia 5 Schizophrenia 7
Schizophrenia 8 Schizophrenia 2
Schizophrenia 9 Schizophrenia 10
Schizophrenia 11 Schizophrenia 12
Schizophrenia 14 Schizophrenia 13
Schizophrenia 15 Schizophrenia 16
Schizophrenia 18 Schizophrenia 19
Early-Onset Schizophrenia

Diseases related to Early-Onset Schizophrenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 depression 29.9 BDNF HTR2A
2 anxiety 29.7 BDNF HTR2A
3 obsessive-compulsive disorder 29.6 BDNF DRD1 HTR2A
4 psychotic disorder 29.4 BDNF DRD1 HTR2A
5 attention deficit-hyperactivity disorder 29.4 BDNF DRD1 HTR2A
6 childhood-onset schizophrenia 11.6
7 schizophrenia 11.1
8 bipolar disorder 10.2
9 autism 10.1
10 autism spectrum disorder 10.1
11 rubeosis iridis 10.1 INS NDUFS4
12 drug-induced mental disorder 10.0 HTR2A NDUFS4
13 drug psychosis 10.0 HTR2A NDUFS4
14 paranoid schizophrenia 10.0 BDNF HTR2A
15 borderline personality disorder 10.0 BDNF HTR2A
16 pathological gambling 10.0 DRD1 HTR2A
17 personality disorder 10.0 BDNF HTR2A
18 mental depression 10.0 BDNF HTR2A
19 apnea, obstructive sleep 10.0 HTR2A INS
20 generalized anxiety disorder 10.0 BDNF HTR2A
21 bulimia nervosa 9.9 BDNF HTR2A
22 post-traumatic stress disorder 9.9 BDNF HTR2A
23 schizoaffective disorder 9.9 BDNF HTR2A
24 alzheimer disease 9.9
25 gilles de la tourette syndrome 9.9
26 pol iii-related leukodystrophies 9.9
27 asperger syndrome 9.9
28 periventricular leukomalacia 9.9
29 neuroleptic malignant syndrome 9.9
30 tic disorder 9.9
31 substance-induced psychosis 9.9
32 leukomalacia 9.9
33 disease of mental health 9.9 BDNF HTR2A
34 sleep apnea 9.9 HTR2A INS
35 mood disorder 9.8 BDNF HTR2A
36 anorexia nervosa 9.8 BDNF HTR2A
37 bipolar i disorder 9.7 BDNF DRD1 HTR2A
38 endogenous depression 9.7 BDNF HTR2A INS
39 alcohol abuse 9.7 BDNF DRD1 HTR2A
40 alcohol dependence 9.7 BDNF DRD1 HTR2A
41 nervous system disease 9.7 BDNF INS
42 parkinson disease, late-onset 9.5 BDNF DRD1 HTR2A NDUFS4

Graphical network of the top 20 diseases related to Early-Onset Schizophrenia:



Diseases related to Early-Onset Schizophrenia

Symptoms & Phenotypes for Early-Onset Schizophrenia

MGI Mouse Phenotypes related to Early-Onset Schizophrenia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 BDNF DRD1 HTR2A INS NDUFS4
2 cellular MP:0005384 9.77 BDNF DNMT3B DRD1 INS NDUFS4
3 digestive/alimentary MP:0005381 9.62 BDNF DRD1 HTR2A INS
4 integument MP:0010771 9.56 BDNF DRD1 INS NDUFS4
5 muscle MP:0005369 9.46 DRD1 HTR2A INS NDUFS4
6 nervous system MP:0003631 9.35 BDNF DNMT3B DRD1 INS NDUFS4
7 vision/eye MP:0005391 9.02 BDNF DNMT3B DRD1 INS NDUFS4

Drugs & Therapeutics for Early-Onset Schizophrenia

Search Clinical Trials , NIH Clinical Center for Early-Onset Schizophrenia

Genetic Tests for Early-Onset Schizophrenia

Anatomical Context for Early-Onset Schizophrenia

MalaCards organs/tissues related to Early-Onset Schizophrenia:

42
Brain, Cortex, Testes, Temporal Lobe, Thalamus, Cingulate Cortex, Prefrontal Cortex

Publications for Early-Onset Schizophrenia

Articles related to Early-Onset Schizophrenia:

(show top 50) (show all 231)
# Title Authors Year
1
Altered dynamic global signal topography in antipsychotic-naive adolescents with early-onset schizophrenia. ( 30772067 )
2019
2
GRIN2B promoter methylation deficits in early-onset schizophrenia and its association with cognitive function. ( 30785307 )
2019
3
Associations between cognition and internalizing problems in young adults with early-onset schizophrenia: A 13-year follow-up study. ( 29709790 )
2018
4
Do clinical characteristics predict the cognitive course in early-onset schizophrenia-spectrum disorders? ( 29573345 )
2018
5
Developmental vulnerability to psychosis: Selective aggregation of basic self-disturbance in early onset schizophrenia. ( 29804931 )
2018
6
Predictors and Moderators of Antipsychotic-Related Weight Gain in the Treatment of Early-Onset Schizophrenia Spectrum Disorders Study. ( 29920116 )
2018
7
Very early onset schizophrenia diagnostic challenge and cognitive remediation-A case report. ( 29529420 )
2018
8
Exploration and characterisation of the phenotypic and genetic profiles of patients with early onset schizophrenia associated with autism spectrum disorder and their first-degree relatives: a French multicentre case series study protocol (GenAuDiss). ( 29980548 )
2018
9
Impact of individualized education plans on academic success of youth with early onset schizophrenia. ( 29952742 )
2018
10
Validation study of the early onset schizophrenia diagnosis in the Danish Psychiatric Central Research Register. ( 29299680 )
2018
11
The interaction of NOS1AP, DISC1, DAOA, and GSK3B confers susceptibility of early-onset schizophrenia in Chinese Han population. ( 29100974 )
2018
12
Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study. ( 30472510 )
2018
13
Relationship of common variants in CHRNA5 with early-onset schizophrenia and executive function. ( 30366711 )
2018
14
Gender differences in the prevalence, comorbidities and antipsychotic prescription of early-onset schizophrenia: a nationwide population-based study in Taiwan. ( 30382356 )
2018
15
Cerebellar volume in early-onset schizophrenia and its association with severity of symptoms. ( 30304968 )
2018
16
Early Onset Schizophrenia Associated With Obsessive-Compulsive Disorder: Clinical Features and Correlates. ( 28976410 )
2017
17
Pharmacotherapy effectiveness for clinical subgroups among children and adolescents with early onset schizophrenia. ( 28370310 )
2017
18
Predictors of treatment response and drop out in the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study. ( 28595147 )
2017
19
Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia. ( 28793242 )
2017
20
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
21
Asperger syndrome and early-onset schizophrenia associated with a novel MECP2 deleterious missense variant. ( 28230711 )
2017
22
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28657177 )
2017
23
Treatment retention of risperidone long-acting injection in patients with early-onset schizophrenia in Japan. ( 28558887 )
2017
24
Clozapine-Induced Microseizures, Orofacial Dyskinesia, and Speech Dysfluency in an Adolescent with Treatment Resistant Early Onset Schizophrenia on Concurrent Lithium Therapy. ( 28835863 )
2017
25
Early-onset schizophrenia: Symptoms and social class of origin. ( 28701088 )
2017
26
Add-on Gabapentin Alleviates Paliperidone-induced Head Tremors and Boosts Antipsychotic Response in Early-Onset Schizophrenia ( 29644812 )
2017
27
Pronounced inhibition-related hypofrontal dysfunction in early-onset schizophrenia as indexed by NoGo-P300 amplitude. ( 28174035 )
2017
28
Clozapine-Related Tachycardia in an Adolescent with Treatment-Resistant Early Onset Schizophrenia. ( 28323458 )
2017
29
Diagnostic clusters associated with an early onset schizophrenia diagnosis among children and adolescents. ( 28370311 )
2017
30
Evaluation of white matter structure changes, as assessed in tractography, and cognitive dysfunctions in patients with early onset schizophrenia and their first-degree relatives. ( 28987061 )
2017
31
White Matter Microstructure in Early-Onset Schizophrenia: A Systematic Review of Diffusion Tensor Imaging Studies. ( 27015717 )
2016
32
Theory of mind in adolescents with early-onset schizophrenia: correlations with clinical assessment and executive functions. ( 26916502 )
2016
33
Disrupted amplitude of low-frequency fluctuations in antipsychotic-naA^ve adolescents with early-onset schizophrenia. ( 27000303 )
2016
34
Challenges in the Psychopharmacological Management of Very Early-Onset Schizophrenia and Anxiety. ( 27992258 )
2016
35
Serum IL-4 and IL-10 Levels Correlate with the Symptoms of the Drug-Naive Adolescents with First Episode, Early Onset Schizophrenia. ( 27384868 )
2016
36
Time perception of simultaneous and sequential events in early-onset schizophrenia. ( 27388526 )
2016
37
Altered expression of mRNA profiles in blood of early-onset schizophrenia. ( 26733343 )
2016
38
Gestational length affects neurocognition in early-onset schizophrenia. ( 27474856 )
2016
39
Cortisol and ACTH levels in drug-naive adolescents with first-episode early onset schizophrenia. ( 27804260 )
2016
40
Time to Initiation of Clozapine Treatment in Children and Adolescents with Early-Onset Schizophrenia. ( 27737473 )
2016
41
A Systematic Review and Network Meta-Analysis to Assess the Relative Efficacy of Antipsychotics for the Treatment of Positive and Negative Symptoms in Early-Onset Schizophrenia. ( 26801655 )
2016
42
Atypical antipsychotics in the treatment of early-onset schizophrenia. ( 25897226 )
2015
43
White matter fractional anisotropy over two time points in early onset schizophrenia and adolescent cannabis use disorder: A naturalistic diffusion tensor imaging study. ( 25779033 )
2015
44
Assessing and Treating Early Onset Schizophrenia at Schools. ( 26101010 )
2015
45
Impaired Verbal Learning Is Associated with Larger Caudate Volumes in Early Onset Schizophrenia Spectrum Disorders. ( 26230626 )
2015
46
Reduced event-related low frequency EEG activity in patients with early onset schizophrenia and their unaffected siblings. ( 25745977 )
2015
47
Psychosocial interventions for very early and early-onset schizophrenia: a review of treatment efficacy. ( 26001923 )
2015
48
Bromocriptine mitigated paliperidone metabolic and neuro-hormonal side effects and improved negative domain in a case of early onset schizophrenia. ( 26573387 )
2015
49
Gene expression profiling in peripheral blood mononuclear cells of early-onset schizophrenia. ( 26484249 )
2015
50
Facial, vocal and cross-modal emotion processing in early-onset schizophrenia spectrum disorders. ( 26297473 )
2015

Variations for Early-Onset Schizophrenia

Expression for Early-Onset Schizophrenia

Search GEO for disease gene expression data for Early-Onset Schizophrenia.

Pathways for Early-Onset Schizophrenia

GO Terms for Early-Onset Schizophrenia

Cellular components related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of presynaptic membrane GO:0099056 8.96 DRD1 HTR2A
2 integral component of postsynaptic membrane GO:0099055 8.62 DRD1 HTR2A

Biological processes related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 DNMT3B DRD1 INS
2 response to drug GO:0042493 9.54 DNMT3B DRD1 HTR2A
3 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.51 DRD1 HTR2A
4 synapse assembly GO:0007416 9.49 BDNF DRD1
5 regulation of protein phosphorylation GO:0001932 9.46 DRD1 NDUFS4
6 regulation of synaptic vesicle exocytosis GO:2000300 9.43 DRD1 HTR2A
7 response to cocaine GO:0042220 9.4 DNMT3B DRD1
8 activation of phospholipase C activity GO:0007202 9.32 BDNF HTR2A
9 temperature homeostasis GO:0001659 9.26 DRD1 HTR2A
10 behavioral response to cocaine GO:0048148 9.16 DRD1 HTR2A
11 positive regulation of glycolytic process GO:0045821 8.96 HTR2A INS
12 memory GO:0007613 8.8 BDNF DRD1 HTR2A

Molecular functions related to Early-Onset Schizophrenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein alpha-subunit binding GO:0001965 8.62 DRD1 HTR2A

Sources for Early-Onset Schizophrenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....