MCID: ERL052
MIFTS: 20

Early Repolarization Associated with Ventricular Fibrillation

Aliases & Classifications for Early Repolarization Associated with Ventricular Fibrillation

MalaCards integrated aliases for Early Repolarization Associated with Ventricular Fibrillation:

Name: Early Repolarization Associated with Ventricular Fibrillation 57 29 6 73
Early Repolarization Syndrome 57

External Ids:

OMIM 57 613601
MedGen 42 C3150852
UMLS 73 C3150852

Summaries for Early Repolarization Associated with Ventricular Fibrillation

OMIM : 57 Electrocardiographic (ECG) early repolarization, defined as an elevation of the QRS-ST junction (J-point) of at least 1.0 mm (0.1 mV) from baseline in the inferior or lateral lead, manifest as QRS slurring or notching, is a common ECG finding that is generally considered to be benign but may be associated with ventricular fibrillation in some patients (summary by Haissaguerre et al., 2008). (613601)

MalaCards based summary : Early Repolarization Associated with Ventricular Fibrillation, also known as early repolarization syndrome, is related to ventricular fibrillation, paroxysmal familial, 1 and brugada syndrome. An important gene associated with Early Repolarization Associated with Ventricular Fibrillation is CACNB2 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2). Affiliated tissues include heart.

Related Diseases for Early Repolarization Associated with Ventricular Fibrillation

Diseases related to Early Repolarization Associated with Ventricular Fibrillation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 ventricular fibrillation, paroxysmal familial, 1 10.5
2 brugada syndrome 10.3
3 arteries, anomalies of 10.0
4 cardiac conduction defect 10.0
5 myocardial infarction 10.0
6 coronary artery anomaly 10.0
7 progressive familial heart block, type ia 9.8
8 progressive familial heart block, type ib 9.8
9 right bundle branch block 9.8
10 hypokalemia 9.8
11 acute disseminated encephalomyelitis 9.8
12 syncope 9.8

Graphical network of the top 20 diseases related to Early Repolarization Associated with Ventricular Fibrillation:



Diseases related to Early Repolarization Associated with Ventricular Fibrillation

Symptoms & Phenotypes for Early Repolarization Associated with Ventricular Fibrillation

Clinical features from OMIM:

613601

Drugs & Therapeutics for Early Repolarization Associated with Ventricular Fibrillation

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gated SPECT Abnormality With J Point Elevation Completed NCT03472898
2 Early Repolarization Syndrome: Define the Risk, Stratify the Coverage and Understand the Causes - Clinical and Genetic Study Recruiting NCT02847039
3 VF Mapping in Brugada and Early Repolarization Syndromes Recruiting NCT03764592
4 Registry of Unexplained Cardiac Arrest Recruiting NCT00292032
5 Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias Enrolling by invitation NCT02413450

Search NIH Clinical Center for Early Repolarization Associated with Ventricular Fibrillation

Genetic Tests for Early Repolarization Associated with Ventricular Fibrillation

Genetic tests related to Early Repolarization Associated with Ventricular Fibrillation:

# Genetic test Affiliating Genes
1 Early Repolarization Associated with Ventricular Fibrillation 29

Anatomical Context for Early Repolarization Associated with Ventricular Fibrillation

MalaCards organs/tissues related to Early Repolarization Associated with Ventricular Fibrillation:

41
Heart

Publications for Early Repolarization Associated with Ventricular Fibrillation

Articles related to Early Repolarization Associated with Ventricular Fibrillation:

(show top 50) (show all 77)
# Title Authors Year
1
SCN1Bβ mutations that affect their association with Kv4.3 underlie early repolarization syndrome. ( 30160358 )
2018
2
Prevalence of early repolarization syndrome and long-term clinical outcome in patients with the diagnosis of idiopathic ventricular fibrillation. ( 30288567 )
2018
3
Epicardial Substrate as a Target for Radiofrequency Ablation in an Experimental Model of Early Repolarization Syndrome. ( 30354293 )
2018
4
Electrophysiological Basis for Early Repolarization Syndrome. ( 30460246 )
2018
5
A Slower Heart Rate and Therapeutic Hypothermia Unmasked Early Repolarization Syndrome in a Ventricular Fibrillation Survivor. ( 30464125 )
2018
6
A Heterozygous Missense hERG Mutation Associated with Early Repolarization Syndrome. ( 30481776 )
2018
7
Early Repolarization Syndrome: Diagnostic and Therapeutic Approach. ( 30542653 )
2018
8
Mutation in KCNE1 associated to early repolarization syndrome by modulation of slowly activating delayed rectifier K+ current. ( 29395134 )
2018
9
Significance of Coronary Artery Spasm Diagnosis in Patients With Early Repolarization Syndrome. ( 29436392 )
2018
10
A mutation in the CACNA1C gene leads to early repolarization syndrome with incomplete penetrance: A Chinese family study. ( 28493952 )
2017
11
Ventricular Fibrillation Due to Early Repolarization Syndrome in the Wake of Hypothermia Due to Fulminant Acute Disseminated Encephalomyelitis. ( 28931785 )
2017
12
Early repolarization syndrome and Brugada syndrome: Similar or different? ( 27940004 )
2017
13
Incidence of Atrial Tachyarrhythmias in Patients With Early Repolarization Syndrome. ( 28077816 )
2017
14
Intracoronary acetylcholine application as a possible probe inducing J waves in patients with early repolarization syndrome. ( 29021844 )
2017
15
Author Reply to Letter to the Editor: Silent and Malignant Early Repolarization Syndrome Mimicking Hyper-Acute ST Elevation Myocardial Infarction. ( 29033520 )
2017
16
The Electrophysiological Substrate of Early Repolarization Syndrome: Noninvasive Mapping in Patients. ( 29130071 )
2017
17
Early repolarization syndrome caused by de novo duplication of KCND3 detected by next-generation sequencing. ( 29296579 )
2017
18
A novel mutation in the SCN5A gene contributes to arrhythmogenic characteristics of early repolarization syndrome. ( 26820605 )
2016
19
A patient with early repolarization syndrome and concurrent Brugada syndrome: Demonstration of a different pathophysiology? ( 27529593 )
2016
20
Variants of Brugada Syndrome and Early Repolarization Syndrome: An Expanded Concept of J-Wave Syndrome. ( 28000227 )
2016
21
Tachyarrhythmia Cycle Length in Appropriate versus Inappropriate Defibrillator Shocks in Brugada Syndrome, Early Repolarization Syndrome, or Idiopathic Ventricular Fibrillation. ( 27014348 )
2016
22
Significance of electrocardiogram recording in high intercostal spaces in patients with early repolarization syndrome. ( 26261291 )
2016
23
Ablation of Left Ventricular Substrate in Early Repolarization Syndrome. ( 26467677 )
2016
24
Cellular and ionic mechanisms underlying the effects of cilostazol, milrinone, and isoproterenol to suppress arrhythmogenesis in an experimental model of early repolarization syndrome. ( 26820510 )
2016
25
MY APPROACH to early repolarization syndrome. ( 26944231 )
2016
26
Effect of flecainide on suppression of ventricular fibrillation in a patient with early repolarization syndrome. ( 27033341 )
2016
27
Reply to the Editor- Effect of Flecainide on Suppression of Ventricular Fibrillation in a Patient With Early Repolarization Syndrome. ( 27320516 )
2016
28
To the Editor-Flecainide and ventricular fibrillation in patients with early repolarization syndrome. ( 27343857 )
2016
29
Early Repolarization Syndrome; Mechanistic Theories and Clinical Correlates. ( 27445855 )
2016
30
Silent and Malignant Early Repolarization Syndrome Mimicking Hyper-Acute ST Elevation Myocardial Infarction. ( 27471366 )
2016
31
Radiofrequency catheter ablation for treatment of premature ventricular contractions triggering ventricular fibrillation from the right ventricular outflow tract in a patient with early repolarization syndrome. ( 28491706 )
2016
32
Early repolarization syndrome: A cause of sudden cardiac death. ( 26322186 )
2015
33
History and clinical significance of early repolarization syndrome. ( 25257090 )
2015
34
Role of electrophysiological studies in predicting risk of ventricular arrhythmia in early repolarization syndrome. ( 25593056 )
2015
35
Ventricular fibrillation inducibility in the early repolarization syndrome: we still haven't found what we're looking for. ( 25593057 )
2015
36
Premature ventricular beats initiate recurrent ventricular fibrillation in early repolarization syndrome. ( 26336542 )
2015
37
Early repolarization syndrome: A case report focusing on dynamic electrocardiographic changes before ventricular arrhythmias and genetic analysis. ( 28491551 )
2015
38
ABCC9 is a novel Brugada and early repolarization syndrome susceptibility gene. ( 24439875 )
2014
39
Early repolarization syndrome: electrocardiographic signs and clinical implications. ( 24118137 )
2014
40
J wave elevation to monitor quinidine efficacy in early repolarization syndrome. ( 24332747 )
2014
41
Mechanisms underlying the development of the electrocardiographic and arrhythmic manifestations of early repolarization syndrome. ( 24378566 )
2014
42
Stop "Early repolarization syndrome", start "Haissaguerre syndrome". ( 24440314 )
2014
43
A diagnostic dilemma: early repolarization syndrome associated with ventricular fibrillation. ( 24481099 )
2014
44
Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. ( 24491875 )
2014
45
Evaluation Of Patients With Early Repolarization Syndrome. ( 27957112 )
2014
46
Role of mutations in L-type calcium channel genes in Brugada syndrome, early repolarization syndrome, and idiopathic ventricular fibrillation associated with right bundle branch block. ( 23739544 )
2013
47
Ventricular fibrillation induced by spontaneous hypothermia in a patient with early repolarization syndrome. ( 23140469 )
2013
48
Beneficial effects of cilostazol in a patient with recurrent ventricular fibrillation associated with early repolarization syndrome. ( 23142636 )
2013
49
Identification of large families in early repolarization syndrome. ( 23273290 )
2013
50
Impaired ventricular repolarization dynamics in patients with early repolarization syndrome. ( 23373546 )
2013

Variations for Early Repolarization Associated with Ventricular Fibrillation

ClinVar genetic disease variations for Early Repolarization Associated with Ventricular Fibrillation:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CACNB2 NM_000724.3(CACNB2): c.476G> C (p.Ser159Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs149253719 GRCh37 Chromosome 10, 18795447: 18795447
2 CACNB2 NM_000724.3(CACNB2): c.476G> C (p.Ser159Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs149253719 GRCh38 Chromosome 10, 18506518: 18506518

Expression for Early Repolarization Associated with Ventricular Fibrillation

Search GEO for disease gene expression data for Early Repolarization Associated with Ventricular Fibrillation.

Pathways for Early Repolarization Associated with Ventricular Fibrillation

GO Terms for Early Repolarization Associated with Ventricular Fibrillation

Sources for Early Repolarization Associated with Ventricular Fibrillation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....