MCID: ERL052
MIFTS: 23

Early Repolarization Associated with Ventricular Fibrillation

Aliases & Classifications for Early Repolarization Associated with Ventricular Fibrillation

MalaCards integrated aliases for Early Repolarization Associated with Ventricular Fibrillation:

Name: Early Repolarization Associated with Ventricular Fibrillation 57 29 6 72
Early Repolarization Syndrome 57

External Ids:

OMIM 57 613601
MedGen 42 C3150852
UMLS 72 C3150852

Summaries for Early Repolarization Associated with Ventricular Fibrillation

OMIM : 57 Electrocardiographic (ECG) early repolarization, defined as an elevation of the QRS-ST junction (J-point) of at least 1.0 mm (0.1 mV) from baseline in the inferior or lateral lead, manifest as QRS slurring or notching, is a common ECG finding that is generally considered to be benign but may be associated with ventricular fibrillation in some patients (summary by Haissaguerre et al., 2008). (613601)

MalaCards based summary : Early Repolarization Associated with Ventricular Fibrillation, also known as early repolarization syndrome, is related to ventricular fibrillation, paroxysmal familial, 1 and brugada syndrome. An important gene associated with Early Repolarization Associated with Ventricular Fibrillation is CACNB2 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2). Affiliated tissues include heart, testes and thyroid.

Related Diseases for Early Repolarization Associated with Ventricular Fibrillation

Diseases related to Early Repolarization Associated with Ventricular Fibrillation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 ventricular fibrillation, paroxysmal familial, 1 10.7
2 brugada syndrome 10.5
3 cardiac conduction defect 10.5
4 syncope 10.3
5 cardiac arrest 10.2
6 progressive familial heart block, type ia 10.1
7 progressive familial heart block, type ib 10.1
8 right bundle branch block 10.1
9 cardiac arrhythmia 10.1
10 pericarditis 10.1
11 arteries, anomalies of 10.0
12 hyperlipoproteinemia, type iii 10.0
13 coronary artery anomaly 10.0
14 hypokalemia 10.0
15 myocardial infarction 9.8
16 ischemia 9.8
17 acute disseminated encephalomyelitis 9.8
18 cantú syndrome and related disorders 9.8
19 hypertrophic cardiomyopathy 9.8

Symptoms & Phenotypes for Early Repolarization Associated with Ventricular Fibrillation

Clinical features from OMIM:

613601

Drugs & Therapeutics for Early Repolarization Associated with Ventricular Fibrillation

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Repolarization Syndrome: Define the Risk, Stratify the Coverage and Understand the Causes - Clinical and Genetic Study Recruiting NCT02847039
2 China Inherited Ventricular Arrhythmias Registry, a Multicenter, Observational and Prospective Study Recruiting NCT03880708
3 Arrhythmogenic Substrate Assessment in Patients With Primary Cardiomyopathies. A Prospective Follow-up Study Recruiting NCT03304847
4 Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias (Long QT Syndrome, Brugada Syndrome, CPVT and Early Repolarization Syndrome) Enrolling by invitation NCT02413450

Search NIH Clinical Center for Early Repolarization Associated with Ventricular Fibrillation

Genetic Tests for Early Repolarization Associated with Ventricular Fibrillation

Genetic tests related to Early Repolarization Associated with Ventricular Fibrillation:

# Genetic test Affiliating Genes
1 Early Repolarization Associated with Ventricular Fibrillation 29

Anatomical Context for Early Repolarization Associated with Ventricular Fibrillation

MalaCards organs/tissues related to Early Repolarization Associated with Ventricular Fibrillation:

41
Heart, Testes, Thyroid, Cardiac Myocytes

Publications for Early Repolarization Associated with Ventricular Fibrillation

Articles related to Early Repolarization Associated with Ventricular Fibrillation:

(show top 50) (show all 178)
# Title Authors PMID Year
1
Sudden cardiac arrest associated with early repolarization. 8
18463377 2008
2
Tpeak-Tend Interval as a Marker of Arrhythmic Risk in Early Repolarization Syndrome. 38
31432584 2019
3
Successful treatment of electrical storm in a child with early repolarization syndrome with orciprenaline and radiofrequency ablation. 38
31375645 2019
4
Experimental verification of the value of the Tpeak -Tend interval in ventricular arrhythmia inducibility in an early repolarization syndrome model. 38
31424133 2019
5
Transient high-degree right bundle branch block masking the type 1 Brugada ECG pattern associated with possible transient early repolarization syndrome. 38
31343106 2019
6
Quinidine-A legacy within the modern era of antiarrhythmic therapy. 38
31026503 2019
7
A de novo gain-of-function KCND3 mutation in early repolarization syndrome. 38
31173922 2019
8
Early repolarization and risk of lone atrial fibrillation. 38
30661277 2019
9
Prevalence of early repolarization syndrome and long-term clinical outcome in patients with the diagnosis of idiopathic ventricular fibrillation. 38
30288567 2019
10
Revelation of early repolarization by eliminating accessory pathway in manifest Wolff-Parkinson-White syndrome: A case report. 38
31007798 2019
11
Challenge and Impact of Quinidine Access in Sudden Death Syndromes: A National Experience. 38
30898241 2019
12
A Slower Heart Rate and Therapeutic Hypothermia Unmasked Early Repolarization Syndrome in a Ventricular Fibrillation Survivor. 38
30464125 2019
13
Sudden cardiac arrest in patients without overt heart disease: a limited value of next generation sequencing. 38
30403391 2018
14
Control of voltage-driven instabilities in cardiac myocytes with memory. 38
30501225 2018
15
Criteria for ECG detection of acute myocardial ischemia: Sensitivity versus specificity. 38
30177366 2018
16
SCN1Bβ mutations that affect their association with Kv4.3 underlie early repolarization syndrome. 38
30160358 2018
17
[FEATURES OF EARLY REPOLARIZATION SYNDROME DEPENDING ON EVIDENCES OF HEART HYPERTROPHY IN PROFESSIONAL ATHLETES]. 38
30516497 2018
18
Epicardial Substrate as a Target for Radiofrequency Ablation in an Experimental Model of Early Repolarization Syndrome. 38
30354293 2018
19
Sudden cardiac death in J wave syndrome with short QT associated to a novel mutation in Nav 1.8 coding gene SCN10A: First case report for a possible pharmacogenomic role. 38
30177317 2018
20
Repetitive-incessant electrical storm triggered by early repolarization. 38
29205672 2018
21
High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome: a comparison with other inherited primary arrhythmia syndromes. 38
28340026 2018
22
Ventricular Fibrillation Due to Early Repolarization Syndrome in the Wake of Hypothermia Due to Fulminant Acute Disseminated Encephalomyelitis. 38
28931785 2018
23
Epicardial ablation utilizing remote magnetic navigation in a patient with Brugada syndrome and inferior early repolarization. 38
28842979 2018
24
Significance of Coronary Artery Spasm Diagnosis in Patients With Early Repolarization Syndrome. 38
29436392 2018
25
Mutation in KCNE1 associated to early repolarization syndrome by modulation of slowly activating delayed rectifier K+ current. 38
29395134 2018
26
Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis. 38
29383332 2018
27
Early Repolarization Syndrome: Diagnostic and Therapeutic Approach. 38
30542653 2018
28
Electrophysiological Basis for Early Repolarization Syndrome. 38
30460246 2018
29
A Heterozygous Missense hERG Mutation Associated with Early Repolarization Syndrome. 38
30481776 2018
30
The Role of Quinidine in the Pharmacological Therapy of Ventricular Arrhythmias 'Quinidine'. 38
28685701 2018
31
Early repolarization syndrome caused by de novo duplication of KCND3 detected by next-generation sequencing. 38
29296579 2017
32
Cardiac action potential repolarization revisited: early repolarization shows all-or-none behaviour. 38
28815597 2017
33
Intracoronary acetylcholine application as a possible probe inducing J waves in patients with early repolarization syndrome. 38
29021844 2017
34
The new kids on the block of arrhythmogenic disorders: Short QT syndrome and early repolarization. 38
28569435 2017
35
A female patient with hypokalaemia-induced J wave syndrome: An unusual case report. 38
28930854 2017
36
The Electrophysiological Substrate of Early Repolarization Syndrome: Noninvasive Mapping in Patients. 38
29130071 2017
37
Author Reply to Letter to the Editor: Silent and Malignant Early Repolarization Syndrome Mimicking Hyper-Acute ST Elevation Myocardial Infarction. 38
29033520 2017
38
Channelopathies, genetic testing and risk stratification. 38
28343764 2017
39
Targeted Next-Generation Sequencing of 51 Genes Involved in Primary Electrical Disease. 38
28341588 2017
40
Differences in the onset mode of ventricular tachyarrhythmia between patients with J wave in anterior leads and those with J wave in inferolateral leads. 38
27890733 2017
41
Exaggerated Reactivity of Parasympathetic Nerves Is Involved in Ventricular Fibrillation in J-Wave Syndrome. 38
27885745 2017
42
Variants of Brugada Syndrome and Early Repolarization Syndrome: An Expanded Concept of J-Wave Syndrome. 38
28000227 2017
43
Incidence of Atrial Tachyarrhythmias in Patients With Early Repolarization Syndrome. 38
28077816 2017
44
Early repolarization syndrome and Brugada syndrome: Similar or different? 38
27940004 2017
45
A mutation in the CACNA1C gene leads to early repolarization syndrome with incomplete penetrance: A Chinese family study. 38
28493952 2017
46
Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young. 38
27218670 2016
47
Validation of the vessel-specific leads (VSLs) for detection of acute ischemia on a dataset with non-ischemic ST-segment deviation. 38
27662776 2016
48
Sodium channel blockade unmasked Brugada electrocardiographic pattern in a patient with complete right bundle branch block and early repolarization in the lateral leads. 38
27830074 2016
49
A patient with early repolarization syndrome and concurrent Brugada syndrome: Demonstration of a different pathophysiology? 38
27529593 2016
50
Polymorphic Ventricular Tachycardia/Ventricular Fibrillation and Sudden Cardiac Death in the Normal Heart. 38
27521091 2016

Variations for Early Repolarization Associated with Ventricular Fibrillation

ClinVar genetic disease variations for Early Repolarization Associated with Ventricular Fibrillation:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 CACNB2 NM_201590.3(CACNB2): c.479G> C (p.Ser160Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs149253719 10:18795447-18795447 10:18506518-18506518

Expression for Early Repolarization Associated with Ventricular Fibrillation

Search GEO for disease gene expression data for Early Repolarization Associated with Ventricular Fibrillation.

Pathways for Early Repolarization Associated with Ventricular Fibrillation

GO Terms for Early Repolarization Associated with Ventricular Fibrillation

Sources for Early Repolarization Associated with Ventricular Fibrillation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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