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MCID: ERL052
MIFTS: 22

Early Repolarization Associated with Ventricular Fibrillation

Genes Variations Tissues Related diseases Publications
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Aliases & Classifications for Early Repolarization Associated with Ventricular Fibrillation

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MalaCards integrated aliases for Early Repolarization Associated with Ventricular Fibrillation:

Name: Early Repolarization Associated with Ventricular Fibrillation 56 29 6 71
Early Repolarization Syndrome 56

External Ids:

OMIM 56 613601
MedGen 41 C3150852
UMLS 71 C3150852
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Summaries for Early Repolarization Associated with Ventricular Fibrillation

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OMIM : 56 Electrocardiographic (ECG) early repolarization, defined as an elevation of the QRS-ST junction (J-point) of at least 1.0 mm (0.1 mV) from baseline in the inferior or lateral lead, manifest as QRS slurring or notching, is a common ECG finding that is generally considered to be benign but may be associated with ventricular fibrillation in some patients (summary by Haissaguerre et al., 2008). (613601)

MalaCards based summary : Early Repolarization Associated with Ventricular Fibrillation, also known as early repolarization syndrome, is related to ventricular fibrillation, paroxysmal familial, 1 and brugada syndrome. An important gene associated with Early Repolarization Associated with Ventricular Fibrillation is CACNB2 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2). Affiliated tissues include heart, testes and thyroid.

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Related Diseases for Early Repolarization Associated with Ventricular Fibrillation

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Diseases related to Early Repolarization Associated with Ventricular Fibrillation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 ventricular fibrillation, paroxysmal familial, 1 10.7
2 brugada syndrome 10.5
3 cardiac conduction defect 10.5
4 syncope 10.3
5 cardiac arrest 10.3
6 progressive familial heart block, type ia 10.1
7 progressive familial heart block, type ib 10.1
8 right bundle branch block 10.1
9 cardiac arrhythmia 10.1
10 pericarditis 10.1
11 arteries, anomalies of 10.0
12 hyperlipoproteinemia, type iii 10.0
13 lipoprotein quantitative trait locus 10.0
14 hypokalemia 10.0
15 myocardial infarction 9.8
16 atrioventricular block 9.8
17 hypertrophic cardiomyopathy 9.8
18 ischemia 9.8
19 acute disseminated encephalomyelitis 9.8
20 cantú syndrome and related disorders 9.8

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Symptoms & Phenotypes for Early Repolarization Associated with Ventricular Fibrillation

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Clinical features from OMIM:

613601
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Drugs & Therapeutics for Early Repolarization Associated with Ventricular Fibrillation

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Repolarization Syndrome: Define the Risk, Stratify the Coverage and Understand the Causes - Clinical and Genetic Study Recruiting NCT02847039
2 China Inherited Ventricular Arrhythmias Registry, a Multicenter, Observational and Prospective Study Recruiting NCT03880708
3 Arrhythmogenic Substrate Assessment in Patients With Primary Cardiomyopathies. A Prospective Follow-up Study Recruiting NCT03304847
4 Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias (Long QT Syndrome, Brugada Syndrome, CPVT and Early Repolarization Syndrome) Enrolling by invitation NCT02413450

Search NIH Clinical Center for Early Repolarization Associated with Ventricular Fibrillation

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Genetic Tests for Early Repolarization Associated with Ventricular Fibrillation

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Genetic tests related to Early Repolarization Associated with Ventricular Fibrillation:

# Genetic test Affiliating Genes
1 Early Repolarization Associated with Ventricular Fibrillation 29
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Anatomical Context for Early Repolarization Associated with Ventricular Fibrillation

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MalaCards organs/tissues related to Early Repolarization Associated with Ventricular Fibrillation:

40
Heart, Testes, Thyroid, Cardiac Myocytes
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Publications for Early Repolarization Associated with Ventricular Fibrillation

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Articles related to Early Repolarization Associated with Ventricular Fibrillation:

(show top 50) (show all 183)
# Title Authors PMID Year
1
Sudden cardiac arrest associated with early repolarization. 56
18463377 2008
2
Electrocardiographic changes in the differentiation of ischemic and non-ischemic ST elevation. 61
31885293 2020
3
A novel mutation in GPD1‑L associated with early repolarization syndrome via modulation of cardiomyocyte fast sodium currents. 61
31922248 2020
4
The many faces of early repolarization syndrome: A single-center case series. 61
31521808 2020
5
Transient high-degree right bundle branch block masking the type 1 Brugada ECG pattern associated with possible transient early repolarization syndrome. 61
31343106 2020
6
A de novo gain-of-function KCND3 mutation in early repolarization syndrome. 61
31173922 2019
7
A novel DPP6 variant in Chinese families causes early repolarization syndrome. 61
31476289 2019
8
Tpeak-tend interval as a marker of arrhythmic risk in early repolarization syndrome. 61
31432584 2019
9
Mapping and Ablation of Ventricular Fibrillation Associated With Early Repolarization Syndrome. 61
31542949 2019
10
Experimental verification of the value of the Tpeak -Tend interval in ventricular arrhythmia inducibility in an early repolarization syndrome model. 61
31424133 2019
11
Successful treatment of electrical storm in a child with early repolarization syndrome with orciprenaline and radiofrequency ablation. 61
31375645 2019
12
Quinidine-A legacy within the modern era of antiarrhythmic therapy. 61
31026503 2019
13
Early repolarization and risk of lone atrial fibrillation. 61
30661277 2019
14
Revelation of early repolarization by eliminating accessory pathway in manifest Wolff-Parkinson-White syndrome: A case report. 61
31007798 2019
15
Prevalence of early repolarization syndrome and long-term clinical outcome in patients with the diagnosis of idiopathic ventricular fibrillation. 61
30288567 2019
16
Challenge and Impact of Quinidine Access in Sudden Death Syndromes: A National Experience. 61
30898241 2019
17
A Slower Heart Rate and Therapeutic Hypothermia Unmasked Early Repolarization Syndrome in a Ventricular Fibrillation Survivor. 61
30464125 2019
18
Sudden cardiac arrest in patients without overt heart disease: a limited value of next generation sequencing. 61
30403391 2018
19
SCN1Bβ mutations that affect their association with Kv4.3 underlie early repolarization syndrome. 61
30160358 2018
20
Control of voltage-driven instabilities in cardiac myocytes with memory. 61
30501225 2018
21
Criteria for ECG detection of acute myocardial ischemia: Sensitivity versus specificity. 61
30177366 2018
22
[FEATURES OF EARLY REPOLARIZATION SYNDROME DEPENDING ON EVIDENCES OF HEART HYPERTROPHY IN PROFESSIONAL ATHLETES]. 61
30516497 2018
23
Epicardial Substrate as a Target for Radiofrequency Ablation in an Experimental Model of Early Repolarization Syndrome. 61
30354293 2018
24
Sudden cardiac death in J wave syndrome with short QT associated to a novel mutation in Nav 1.8 coding gene SCN10A: First case report for a possible pharmacogenomic role. 61
30177317 2018
25
Repetitive-incessant electrical storm triggered by early repolarization. 61
29205672 2018
26
High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome: a comparison with other inherited primary arrhythmia syndromes. 61
28340026 2018
27
Ventricular Fibrillation Due to Early Repolarization Syndrome in the Wake of Hypothermia Due to Fulminant Acute Disseminated Encephalomyelitis. 61
28931785 2018
28
Epicardial ablation utilizing remote magnetic navigation in a patient with Brugada syndrome and inferior early repolarization. 61
28842979 2018
29
Mutation in KCNE1 associated to early repolarization syndrome by modulation of slowly activating delayed rectifier K+ current. 61
29395134 2018
30
Significance of Coronary Artery Spasm Diagnosis in Patients With Early Repolarization Syndrome. 61
29436392 2018
31
Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis. 61
29383332 2018
32
Electrophysiological Basis for Early Repolarization Syndrome. 61
30460246 2018
33
Early Repolarization Syndrome: Diagnostic and Therapeutic Approach. 61
30542653 2018
34
A Heterozygous Missense hERG Mutation Associated with Early Repolarization Syndrome. 61
30481776 2018
35
The Role of Quinidine in the Pharmacological Therapy of Ventricular Arrhythmias 'Quinidine'. 61
28685701 2018
36
Early repolarization syndrome caused by de novo duplication of KCND3 detected by next-generation sequencing. 61
29296579 2017
37
Cardiac action potential repolarization revisited: early repolarization shows all-or-none behaviour. 61
28815597 2017
38
Intracoronary acetylcholine application as a possible probe inducing J waves in patients with early repolarization syndrome. 61
29021844 2017
39
The new kids on the block of arrhythmogenic disorders: Short QT syndrome and early repolarization. 61
28569435 2017
40
A female patient with hypokalaemia-induced J wave syndrome: An unusual case report. 61
28930854 2017
41
The Electrophysiological Substrate of Early Repolarization Syndrome: Noninvasive Mapping in Patients. 61
29130071 2017
42
Author Reply to Letter to the Editor: Silent and Malignant Early Repolarization Syndrome Mimicking Hyper-Acute ST Elevation Myocardial Infarction. 61
29033520 2017
43
Channelopathies, genetic testing and risk stratification. 61
28343764 2017
44
Targeted Next-Generation Sequencing of 51 Genes Involved in Primary Electrical Disease. 61
28341588 2017
45
Differences in the onset mode of ventricular tachyarrhythmia between patients with J wave in anterior leads and those with J wave in inferolateral leads. 61
27890733 2017
46
Exaggerated Reactivity of Parasympathetic Nerves Is Involved in Ventricular Fibrillation in J-Wave Syndrome. 61
27885745 2017
47
Variants of Brugada Syndrome and Early Repolarization Syndrome: An Expanded Concept of J-Wave Syndrome. 61
28000227 2017
48
Early repolarization syndrome and Brugada syndrome: Similar or different? 61
27940004 2017
49
Incidence of Atrial Tachyarrhythmias in Patients With Early Repolarization Syndrome. 61
28077816 2017
50
A mutation in the CACNA1C gene leads to early repolarization syndrome with incomplete penetrance: A Chinese family study. 61
28493952 2017
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Variations for Early Repolarization Associated with Ventricular Fibrillation

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ClinVar genetic disease variations for Early Repolarization Associated with Ventricular Fibrillation:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CACNB2 NM_201596.3(CACNB2):c.641G>C (p.Ser214Thr)SNV Conflicting interpretations of pathogenicity 161211 rs149253719 10:18795447-18795447 10:18506518-18506518
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Expression for Early Repolarization Associated with Ventricular Fibrillation

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Search GEO for disease gene expression data for Early Repolarization Associated with Ventricular Fibrillation.
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Pathways for Early Repolarization Associated with Ventricular Fibrillation

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GO Terms for Early Repolarization Associated with Ventricular Fibrillation

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Sources for Early Repolarization Associated with Ventricular Fibrillation

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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