MCID: ERL004
MIFTS: 30

Early Yaws

Categories: Bone diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Early Yaws

MalaCards integrated aliases for Early Yaws:

Name: Early Yaws 12 15 70
Initial Lesions of Yaws 12 32
Bone and Joint Lesions Due to Yaws 12
Frambesia, Initial or Primary 12
Bone and Joint Yaws Lesion 12
Initial Frambesial Ulcer 12
Initial Lesion of Yaws 70
Primary Frambesia 12
Chancre of Yaws 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10568
ICD9CM 34 102.0 102.6
NCIt 50 C41352
ICD10 32 A66.0 A66.6
UMLS 70 C0275990 C0275998 C0343834

Summaries for Early Yaws

Disease Ontology : 12 A yaws that results in initial papule at the site of entry of bacteria. Without treatment, this is followed by disseminated skin lesions over the body. Bone pain and bone lesions may also occur.

MalaCards based summary : Early Yaws, also known as initial lesions of yaws, is related to syphilis and yaws. An important gene associated with Early Yaws is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways are Innate Immune System and PKC-Theta Pathway. Affiliated tissues include bone, skin and thymus.

Related Diseases for Early Yaws

Diseases in the Yaws family:

Late Yaws Early Yaws

Diseases related to Early Yaws via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
# Related Disease Score Top Affiliating Genes
1 syphilis 29.3 TPR CD8A CD4
2 yaws 10.4
3 capillary disease 10.0 CD8A CD22
4 capillary leak syndrome 10.0 CD8A CD22
5 tertiary neurosyphilis 10.0 TPR CD4
6 congenital syphilis 10.0 TPR CD4
7 skin disease 9.9
8 periostitis 9.9
9 cork-handlers' disease 9.9 CD8A CD4
10 necrotic uveal melanoma 9.9 CD8A CD4
11 ventilation pneumonitis 9.9 CD8A CD4
12 diffuse infiltrative lymphocytosis syndrome 9.9 CD8A CD4
13 type 1 diabetes mellitus 23 9.9 CD8A CD4
14 autoimmune lymphoproliferative syndrome, type iia 9.9 CD8A CD4
15 parapsoriasis 9.9 CD8A CD4
16 gastroduodenitis 9.9 CD8A CD4
17 duodenitis 9.9 CD8A CD4
18 norwegian scabies 9.9 CD8A CD4
19 bird fancier's lung 9.9 CD8A CD4
20 skin sarcoidosis 9.9 CD8A CD4
21 metal allergy 9.9 CD8A CD4
22 variola major 9.9 CD8A CD4
23 follicular mucinosis 9.9 CD8A CD4
24 spongiotic dermatitis 9.9 CD8A CD4
25 acute retinal necrosis syndrome 9.9 CD8A CD4
26 cerebral lymphoma 9.9 CD8A CD4
27 oral tuberculosis 9.9 CD8A CD4
28 cerebritis 9.9 CD8A CD4
29 invasive malignant thymoma 9.9 CD8A CD4
30 west nile encephalitis 9.9 CD8A CD4
31 granulomatous hepatitis 9.9 CD8A CD4
32 exanthem 9.9 CD8A CD4
33 exanthema subitum 9.9 CD8A CD4
34 immunodeficiency 36 9.9 CD8A CD4
35 viral exanthem 9.9 CD8A CD4
36 acute interstitial pneumonia 9.9 CD8A CD4
37 glanders 9.9 CD8A CD4
38 oral hairy leukoplakia 9.9 CD8A CD4
39 superficial basal cell carcinoma 9.9 CD8A CD4
40 esophageal candidiasis 9.9 CD8A CD4
41 parotid disease 9.9 CD8A CD4
42 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 9.9 CD8A CD4
43 ulcerative stomatitis 9.9 CD8A CD4
44 granulomatous dermatitis 9.9 CD8A CD4
45 west nile fever 9.9 CD8A CD4
46 neurosarcoidosis 9.9 CD8A CD4
47 retinitis pigmentosa 46 9.9 CD8A CD4
48 pneumonic tularemia 9.9 CD8A CD4
49 tularemia 9.9 CD8A CD4
50 farmer's lung 9.9 CD8A CD4

Graphical network of the top 20 diseases related to Early Yaws:



Diseases related to Early Yaws

Symptoms & Phenotypes for Early Yaws

Drugs & Therapeutics for Early Yaws

Search Clinical Trials , NIH Clinical Center for Early Yaws

Genetic Tests for Early Yaws

Anatomical Context for Early Yaws

MalaCards organs/tissues related to Early Yaws:

40
Bone, Skin, Thymus, Lung, Myeloid, Lymph Node, Spinal Cord

Publications for Early Yaws

Articles related to Early Yaws:

(show all 12)
# Title Authors PMID Year
1
A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. 61
28072863 2017
2
Osteoperiostitis in early yaws: case series and literature review. 61
21367729 2011
3
The localisation of treponemes and characterisation of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws. 61
8509088 1993
4
Early yaws: a light microscopic study. 61
2391114 1990
5
Radiological and dermatological findings in two patients suffering from early yaws in Indonesia. 61
2391113 1990
6
Disseminated early yaws: report of a child with a remarkable genital lesion mimicking venereal syphilis. 61
2343008 1990
7
Early yaws, imported in The Netherlands. 61
2583714 1989
8
Fluctuations in antibody levels in infection with Treponema pertenue. A four-year follow-up of Karkar islanders with early yaws. 61
6661116 1983
9
Case for diagnosis. Disseminated (early) yaws. 61
6798505 1981
10
Early yaws. 61
5929695 1966
11
A case of early yaws. 61
13618655 1959
12
Preliminary and short reports; procaine penicillin in early yaws. 61
14814332 1951

Variations for Early Yaws

Expression for Early Yaws

Search GEO for disease gene expression data for Early Yaws.

Pathways for Early Yaws

Pathways related to Early Yaws according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 TPR JUN CD8A CD4 CD22
2
Show member pathways
12.25 JUN CD8A CD4
3
Show member pathways
12.17 JUN CD8A CD4
4
Show member pathways
11.97 JUN CD4 CD22
5 11.67 CD8A CD4 CD22
6 11.57 JUN CD8A CD4
7 11.46 CD8A CD4
8
Show member pathways
11.43 JUN CD4
9 11.41 CD8A CD4
10 11.4 CD8A CD4 CD22
11 11.38 CD8A CD4
12
Show member pathways
11.28 JUN CD8A
13
Show member pathways
11.18 JUN CD8A CD4
14 11.01 CD8A CD4
15 10.85 JUN CD4
16 10.79 CD8A CD4 CD22

GO Terms for Early Yaws

Cellular components related to Early Yaws according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD8A CD4 CD22

Biological processes related to Early Yaws according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 8.96 CD8A CD4
2 positive regulation of monocyte differentiation GO:0045657 8.62 JUN CD4

Molecular functions related to Early Yaws according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD8A CD4

Sources for Early Yaws

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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