MCID: ERL004
MIFTS: 31

Early Yaws

Categories: Bone diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Early Yaws

MalaCards integrated aliases for Early Yaws:

Name: Early Yaws 12 15 71
Initial Lesions of Yaws 12 32
Bone and Joint Lesions Due to Yaws 12
Frambesia, Initial or Primary 12
Bone and Joint Yaws Lesion 12
Initial Frambesial Ulcer 12
Initial Lesion of Yaws 71
Primary Frambesia 12
Chancre of Yaws 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10568
ICD9CM 34 102.0 102.6
NCIt 49 C41352
ICD10 32 A66.0 A66.6
UMLS 71 C0275990 C0275998 C0343834

Summaries for Early Yaws

Disease Ontology : 12 A yaws that results in initial papule at the site of entry of bacteria. Without treatment, this is followed by disseminated skin lesions over the body. Bone pain and bone lesions may also occur.

MalaCards based summary : Early Yaws, also known as initial lesions of yaws, is related to yaws and syphilis. An important gene associated with Early Yaws is CD22 (CD22 Molecule), and among its related pathways/superpathways are T cell receptor signaling pathway and ICos-ICosL Pathway in T-Helper Cell. Affiliated tissues include bone, skin and lung, and related phenotype is mortality/aging.

Related Diseases for Early Yaws

Diseases in the Yaws family:

Late Yaws Early Yaws

Diseases related to Early Yaws via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 278)
# Related Disease Score Top Affiliating Genes
1 yaws 31.0 TPR CD40LG
2 syphilis 28.6 TPR CD8A CD40LG CD4
3 monoclonal paraproteinemia 10.3 CD40LG CD22
4 waldenstroem's macroglobulinemia 10.3 CD40LG CD22
5 mu chain disease 10.2 WAPL CD40LG
6 alpha chain disease 10.2 CD40LG CD22
7 early congenital syphilis 10.2 TPR CD40LG
8 kunjin encephalitis 10.1 JUN CD40LG
9 capillary disease 10.1 CD8A CD22
10 capillary leak syndrome 10.1 CD8A CD22
11 west nile fever 10.0 CD8A CD40LG
12 selective immunoglobulin deficiency disease 10.0 CD8A CD40LG
13 hantavirus pulmonary syndrome 10.0 CD8A CD40LG
14 ebola hemorrhagic fever 10.0 CD8A CD40LG
15 skin disease 10.0
16 periostitis 10.0
17 lassa fever 9.9 CD8A CD40LG
18 riedel's fibrosing thyroiditis 9.9 CD40LG CD4
19 late yaws 9.9 TPR NDUFS3 CD40LG
20 gastroduodenitis 9.9 CD40LG CD4
21 asymptomatic neurosyphilis 9.9 CD40LG CD4
22 transient arthritis 9.9 CD40LG CD4
23 neuroretinitis 9.9 CD40LG CD4
24 meningovascular neurosyphilis 9.9 CD40LG CD4
25 optic papillitis 9.9 CD40LG CD4
26 viral exanthem 9.9 CD40LG CD4
27 cerebral lymphoma 9.9 CD40LG CD4
28 gastrointestinal tuberculosis 9.9 CD40LG CD4
29 mononeuritis of upper limb and mononeuritis multiplex 9.9 CD40LG CD4
30 mononeuritis multiplex 9.9 CD40LG CD4
31 chancroid 9.9 CD40LG CD4
32 cat-scratch disease 9.9 CD40LG CD4
33 exanthema subitum 9.9 CD40LG CD4
34 trichinosis 9.9 CD40LG CD4
35 granulomatous dermatitis 9.9 CD40LG CD4
36 splenic sequestration 9.9 CD40LG CD4
37 abdominal tuberculosis 9.9 CD40LG CD4
38 bartonellosis 9.9 CD40LG CD4
39 pityriasis rosea 9.9 CD40LG CD4
40 scleral disease 9.9 CD40LG CD4
41 autoimmune neuropathy 9.9 CD40LG CD4
42 lung abscess 9.9 CD40LG CD4
43 sporotrichosis 9.9 CD40LG CD4
44 chronic meningitis 9.8 CD40LG CD4
45 parotitis 9.8 CD40LG CD4
46 chlamydia pneumonia 9.8 CD40LG CD4
47 mite infestation 9.8 CD40LG CD4
48 iritis 9.8 CD40LG CD4
49 cranial nerve palsy 9.8 CD40LG CD4
50 pleural empyema 9.8 CD40LG CD4

Graphical network of the top 20 diseases related to Early Yaws:



Diseases related to Early Yaws

Symptoms & Phenotypes for Early Yaws

MGI Mouse Phenotypes related to Early Yaws:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.23 CD22 CD4 CD40LG CD8A JUN NDUFS3

Drugs & Therapeutics for Early Yaws

Search Clinical Trials , NIH Clinical Center for Early Yaws

Genetic Tests for Early Yaws

Anatomical Context for Early Yaws

MalaCards organs/tissues related to Early Yaws:

40
Bone, Skin, Lung, T Cells, B Cells, Eye, Thymus

Publications for Early Yaws

Articles related to Early Yaws:

(show all 12)
# Title Authors PMID Year
1
A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. 61
28072863 2017
2
Osteoperiostitis in early yaws: case series and literature review. 61
21367729 2011
3
The localisation of treponemes and characterisation of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws. 61
8509088 1993
4
Early yaws: a light microscopic study. 61
2391114 1990
5
Radiological and dermatological findings in two patients suffering from early yaws in Indonesia. 61
2391113 1990
6
Disseminated early yaws: report of a child with a remarkable genital lesion mimicking venereal syphilis. 61
2343008 1990
7
Early yaws, imported in The Netherlands. 61
2583714 1989
8
Fluctuations in antibody levels in infection with Treponema pertenue. A four-year follow-up of Karkar islanders with early yaws. 61
6661116 1983
9
Case for diagnosis. Disseminated (early) yaws. 61
6798505 1981
10
Early yaws. 61
5929695 1966
11
A case of early yaws. 61
13618655 1959
12
Preliminary and short reports; procaine penicillin in early yaws. 61
14814332 1951

Variations for Early Yaws

Expression for Early Yaws

Search GEO for disease gene expression data for Early Yaws.

Pathways for Early Yaws

GO Terms for Early Yaws

Biological processes related to Early Yaws according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.13 CD8A CD40LG CD22
2 positive regulation of monocyte differentiation GO:0045657 8.62 JUN CD4

Molecular functions related to Early Yaws according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD8A CD4

Sources for Early Yaws

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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