EEE
MCID: EST003
MIFTS: 39

Eastern Equine Encephalitis (EEE)

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Eastern Equine Encephalitis

MalaCards integrated aliases for Eastern Equine Encephalitis:

Name: Eastern Equine Encephalitis 12 54 60 15 17 3
Eee 12 54 3
Encephalomyelitis, Eastern Equine 45 74
Neuroinvasive Eastern Equine Encephalitis Virus Infection 12
Eastern Equine Encephalomyelitis 60

Characteristics:

Orphanet epidemiological data:

60
eastern equine encephalitis
Inheritance: Not applicable; Prevalence: <1/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:10841
ICD9CM 36 062.2
MeSH 45 D020242
SNOMED-CT 69 40177004
ICD10 34 A83.2
ICD10 via Orphanet 35 A83.2
UMLS via Orphanet 75 C0153065
Orphanet 60 ORPHA83594
UMLS 74 C0153065

Summaries for Eastern Equine Encephalitis

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 83594Disease definitionEastern equine encephalitis (EEE) is an acute arboviral infection caused by an alphavirus of the Togaviridae family transmitted by an infected mosquito, that is characterized by the onset of flulike symptoms including fever, chills, weakness, headache, vomiting, abdominal pain with diarrhea, myalgia, leucocytosis, and hematuria, rapidly progressing to diffuse central nervous system (CNS) involvement with confusion, somnolence, or even coma. Seizures, which may progress to status epilepticus and neurologic sequelae, cranial nerve palsies, and photophobia may occur. EEE is associated with a high rate of morbidity and mortality.Visit the Orphanet disease page for more resources.

MalaCards based summary : Eastern Equine Encephalitis, also known as eee, is related to western equine encephalitis and encephalitis. An important gene associated with Eastern Equine Encephalitis is XYLT1 (Xylosyltransferase 1), and among its related pathways/superpathways is heparan sulfate biosynthesis. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and b cells.

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Eastern equine encephalitis virus, which is transmitted by Aedes, transmitted by Coquillettidia, and transmitted by Culex species of mosquitoes. The infection has symptom sudden onset of headache, has symptom high fever, has symptom chills, has symptom vomiting, has symptom disorientation, has symptom seizures, and has symptom coma.

CDC : 3 EEE virus:

Wikipedia : 77 Eastern equine encephalitis (EEE), commonly called Triple E or, sleeping sickness (not to be confused... more...

Related Diseases for Eastern Equine Encephalitis

Diseases related to Eastern Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 western equine encephalitis 11.8
2 encephalitis 11.2
3 st. louis encephalitis 10.3
4 west nile virus 10.2
5 venezuelan equine encephalitis 10.2
6 louping ill 10.1
7 rift valley fever 10.1
8 coccidioidomycosis 10.1
9 poliomyelitis 10.1
10 lyme disease 10.1
11 lymphocytic choriomeningitis 10.1
12 enterocolitis 10.0
13 autoinflammation with infantile enterocolitis 10.0
14 chikungunya 10.0
15 tetanus 10.0
16 lymphogranuloma venereum 10.0
17 influenza 10.0
18 hemophagocytic lymphohistiocytosis 10.0
19 rabies 10.0
20 newcastle disease 10.0
21 stomatitis 10.0
22 angioid streaks 9.9 XYLT1 XYLT2
23 sotos syndrome 1 9.8 DPH1 XYLT2
24 pseudoxanthoma elasticum 9.7 XYLT1 XYLT2

Graphical network of the top 20 diseases related to Eastern Equine Encephalitis:



Diseases related to Eastern Equine Encephalitis

Symptoms & Phenotypes for Eastern Equine Encephalitis

Drugs & Therapeutics for Eastern Equine Encephalitis

Drugs for Eastern Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Immunologic Factors Phase 2,Phase 1
3
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
4
Aluminum sulfate Approved Phase 1 10043-01-3
5 Antacids Phase 1
6 Gastrointestinal Agents Phase 1
7 Anti-Ulcer Agents Phase 1
8 Adjuvants, Immunologic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Immunogenicity Study of Eastern Equine Encephalitis (EEE) Vaccine Active, not recruiting NCT00584805 Phase 2
2 Safety and Immunogenicity Study of the Eastern Equine Encephalitis (EEE) Vaccine, Inactivated, Dried, TSI-GSD 104, Lot 2-1-89, in Healthy Adult Subjects at Risk of Exposure to Eastern Equine Encephalitis Virus Enrolling by invitation NCT02654509 Phase 2
3 VRC 313: A Trivalent Virus-like Particle (VLP) Encephalitis Vaccine (WEVEE) in Healthy Adults Not yet recruiting NCT03879603 Phase 1

Search NIH Clinical Center for Eastern Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, eastern equine

Genetic Tests for Eastern Equine Encephalitis

Anatomical Context for Eastern Equine Encephalitis

MalaCards organs/tissues related to Eastern Equine Encephalitis:

42
Brain, Testes, B Cells, Kidney, Salivary Gland

Publications for Eastern Equine Encephalitis

Articles related to Eastern Equine Encephalitis:

(show top 50) (show all 261)
# Title Authors Year
1
Aerosol infection of Balb/c mice with eastern equine encephalitis virus; susceptibility and lethality. ( 30611287 )
2019
2
Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants. ( 30742691 )
2019
3
Complex Epidemiological Dynamics of Eastern Equine Encephalitis Virus in Florida. ( 30860014 )
2019
4
Twenty years of surveillance for Eastern equine encephalitis virus in mosquitoes in New York State from 1993 to 2012. ( 29941031 )
2018
5
Eastern Equine Encephalitis Virus in the United States, 2003-2016. ( 29557336 )
2018
6
A Multiagent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus-Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges. ( 29967804 )
2018
7
Eastern equine encephalitis in puppies in Michigan and New York states. ( 29717641 )
2018
8
Large scale complete genome sequencing and phylodynamic analysis of eastern equine encephalitis virus reveal source-sink transmission dynamics in the United States. ( 29618651 )
2018
9
Validation of a Risk Index Model for Predicting Eastern Equine Encephalitis Virus Transmission to Horses in Florida. ( 29722818 )
2018
10
Population genomics of Culiseta melanura, the principal vector of Eastern equine encephalitis virus in the United States. ( 30118494 )
2018
11
A Case of Eastern Equine Encephalitis. ( 30318912 )
2018
12
Transmission of Eastern Equine Encephalitis Virus from an Organ Donor to Three Transplant Recipients. ( 30371754 )
2018
13
Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein. ( 30455470 )
2018
14
Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization. ( 30540945 )
2018
15
Ocular histopathology in Eastern equine encephalitis: A case report. ( 29503959 )
2017
16
Characterization and pathogenesis of aerosolized eastern equine encephalitis in the common marmoset (Callithrix jacchus). ( 28173871 )
2017
17
Fatal Eastern Equine Encephalitis in a Patient on Maintenance Rituximab: A Case Report. ( 28480291 )
2017
18
Seasonal Patterns in Eastern Equine Encephalitis Virus Antibody in Songbirds in Southern Maine. ( 28287934 )
2017
19
Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly. ( 28468889 )
2017
20
Wetland characteristics linked to broad-scale patterns in Culiseta melanura abundance and eastern equine encephalitis virus infection. ( 29047412 )
2017
21
Eastern equine encephalitis. ( 28754695 )
2017
22
Erratum to: Characterization and pathogenesis of aerosolized eastern equine encephalitis in the common marmoset (Callithrix jacchus). ( 28283042 )
2017
23
MRI findings in eastern equine encephalitis: the &amp;quot;parenthesis&amp;quot; sign. ( 26995574 )
2016
24
Rabies direct fluorescent antibody test does not inactivate rabies or eastern equine encephalitis viruses. ( 27079827 )
2016
25
Dynamics of Vector-Host Interactions in Avian Communities in Four Eastern Equine Encephalitis Virus Foci in the Northeastern U.S. ( 26751704 )
2016
26
Locally Acquired Eastern Equine Encephalitis Virus Disease, Arkansas, USA. ( 27662563 )
2016
27
Geography and Timing of Cases of Eastern Equine Encephalitis in New York State from 1992 to 2012. ( 26901637 )
2016
28
Eastern Equine Encephalitis Treated With Intravenous Immunoglobulins. ( 26740855 )
2016
29
Characterizing areas of potential human exposure to eastern equine encephalitis virus using serological and clinical data from horses. ( 27903326 )
2016
30
Host associations of mosquitoes at eastern equine encephalitis virus foci in Connecticut, USA. ( 27577939 )
2016
31
Case of eastern equine encephalitis presenting in winter. ( 27165999 )
2016
32
Widespread Detection of Antibodies to Eastern Equine Encephalitis, West Nile, St. Louis Encephalitis, and Turlock Viruses in Various Species of Wild Birds from Across the United States. ( 27162269 )
2016
33
Vector Competence and Capacity of Culex erraticus (Diptera: Culicidae) for Eastern Equine Encephalitis Virus in the Southeastern United States. ( 26659606 )
2016
34
Serum creatine kinase changes in Eastern equine encephalitis. ( 26463757 )
2015
35
Antibody and Viral Nucleic Acid Testing of Serum and Cerebrospinal Fluid for Diagnosis of Eastern Equine Encephalitis. ( 26063852 )
2015
36
Insights into the recent emergence and expansion of eastern equine encephalitis virus in a new focus in the Northern New England USA. ( 26453283 )
2015
37
Production of a Sindbis/Eastern Equine Encephalitis chimeric virus inactivated cell culture antigen. ( 26205552 )
2015
38
Complete coding sequences of eastern equine encephalitis virus and venezuelan equine encephalitis virus strains isolated from human cases. ( 25908124 )
2015
39
Eastern equine encephalitis incubation time periods of 5 and 8 days. ( 25760571 )
2015
40
Prevalence of eastern equine encephalitis virus antibodies among white-tailed deer populations in maine. ( 25793477 )
2015
41
The first outbreak of eastern equine encephalitis in Vermont: outbreak description and phylogenetic relationships of the virus isolate. ( 26043136 )
2015
42
Eastern equine encephalitis virus in mice II: pathogenesis is dependent on route of exposure. ( 26423229 )
2015
43
Eastern equine encephalitis virus in mice I: clinical course and outcome are dependent on route of exposure. ( 26420265 )
2015
44
Vector-Host Interactions of Culiseta melanura in a Focus of Eastern Equine Encephalitis Virus Activity in Southeastern Virginia. ( 26327226 )
2015
45
Mapping eastern equine encephalitis virus risk for white-tailed deer in Michigan. ( 26494931 )
2015
46
B-93The Neuropsychological Sequelae of Eastern Equine Encephalitis Virus in Childhood. ( 25176843 )
2014
47
Field investigations of winter transmission of eastern equine encephalitis virus in Florida. ( 25070997 )
2014
48
A risk index model for predicting eastern equine encephalitis virus transmission to horses in Florida. ( 24764607 )
2014
49
CpG/Poly (I:C) mixed adjuvant priming enhances the immunogenicity of a DNA vaccine against eastern equine encephalitis virus in mice. ( 24440303 )
2014
50
Detection of Eastern Equine Encephalitis Virus Antibodies in Moose (Alces americana), Maine, 2010. ( 24359417 )
2014

Variations for Eastern Equine Encephalitis

Expression for Eastern Equine Encephalitis

Search GEO for disease gene expression data for Eastern Equine Encephalitis.

Pathways for Eastern Equine Encephalitis

Pathways related to Eastern Equine Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.46 XYLT1 XYLT2

GO Terms for Eastern Equine Encephalitis

Biological processes related to Eastern Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan biosynthetic process GO:0006024 9.37 XYLT1 XYLT2
2 chondroitin sulfate biosynthetic process GO:0030206 9.32 XYLT1 XYLT2
3 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.26 XYLT1 XYLT2
4 proteoglycan biosynthetic process GO:0030166 9.16 XYLT1 XYLT2
5 glycosaminoglycan metabolic process GO:0030203 8.96 XYLT1 XYLT2
6 chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8.62 XYLT1 XYLT2

Molecular functions related to Eastern Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acetylglucosaminyltransferase activity GO:0008375 8.96 XYLT1 XYLT2
2 protein xylosyltransferase activity GO:0030158 8.62 XYLT1 XYLT2

Sources for Eastern Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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