MCID: ECC002
MIFTS: 36

Eccrine Acrospiroma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Eccrine Acrospiroma

MalaCards integrated aliases for Eccrine Acrospiroma:

Name: Eccrine Acrospiroma 12 52 15 17 71
Acrospiroma 52 43 71
Poroma 12 17 71
Eccrine Hidradenoma of Skin 12
Adenoma, Sweat Gland 71
Eccrine Hidradenoma 12
Eccrine Poroma 71
Hidradenoma 52

Classifications:



External Ids:

Disease Ontology 12 DOID:5442
MeSH 43 D018250
NCIt 49 C7568
SNOMED-CT 67 400099008
UMLS 71 C0019522 C0206671 C1533161 more

Summaries for Eccrine Acrospiroma

MalaCards based summary : Eccrine Acrospiroma, also known as acrospiroma, is related to syringocystadenoma papilliferum and clear cell hidradenoma. An important gene associated with Eccrine Acrospiroma is CLEC2A (C-Type Lectin Domain Family 2 Member A), and among its related pathways/superpathways are Developmental Biology and Relaxin signaling pathway. Affiliated tissues include skin, breast and bone, and related phenotype is digestive/alimentary.

Wikipedia : 74 Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. These are 1-3 cm translucent... more...

Related Diseases for Eccrine Acrospiroma

Diseases related to Eccrine Acrospiroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)
# Related Disease Score Top Affiliating Genes
1 syringocystadenoma papilliferum 32.6 PIP KRT19
2 clear cell hidradenoma 32.2 PIP MAML2 KRT7 KRT5 CLEC2A CEACAM5
3 nodular hidradenoma 32.2 PIP KRT7 CLEC2A CEACAM5
4 malignant acrospiroma 32.2 MAML2 KRT7 KRT5 CLEC2A CEACAM5
5 hidradenoma 31.8 PIP MAML2 KRT7 KRT5 KRT15 CLEC2A
6 bowen's disease 31.0 KRT7 KRT10
7 clear cell acanthoma 30.8 KRT10 CLEC2A
8 apocrine adenoma 30.8 PIP KRT7
9 inverted follicular keratosis 30.5 KRT17 CLEC2A
10 follicular infundibulum tumor 30.5 KRT17 CLEC2A
11 syringoma 30.4 KRT7 KRT19 CLEC2A CEACAM5
12 ceruminoma 30.4 PIP KRT7 KRT5
13 benign teratoma 30.3 KRT7 CLEC2A CEACAM5
14 papillary adenoma 30.3 KRT7 KRT5 CEACAM5
15 intraductal papilloma 30.3 KRT7 KRT5 KRT14
16 cystic teratoma 30.3 KRT7 KRT10 CEACAM5
17 rectum adenocarcinoma 30.2 PIP KRT7 CEACAM5
18 vulva cancer 30.2 PIP KRT7 CEACAM5
19 papilloma 30.2 KRT7 KRT5 KRT14 KRT10
20 eccrine porocarcinoma 30.1 MAML2 KRT7 KRT5 KRT15 CEACAM5
21 acanthoma 30.1 KRT7 KRT17 KRT10 CLEC2A
22 mammary paget's disease 30.0 PIP KRT7 KRT14
23 mature teratoma 30.0 KRT7 CEACAM5
24 keratosis 29.9 KRT5 KRT17 KRT10 CEACAM5
25 paget disease, extramammary 29.9 PIP KRT7 KRT5 CEACAM5
26 papillary adenocarcinoma 29.9 PIP KRT7 KRT19 CEACAM5
27 spiradenoma 29.8 KRT7 KRT15 KRT14 CLEC2A
28 ductal carcinoma in situ 29.7 PIP KRT5 KRT14
29 sebaceous adenocarcinoma 29.6 PIP KRT5 KRT14
30 in situ carcinoma 29.5 PIP KRT5 KRT17 KRT14
31 adenosquamous carcinoma 29.4 MAML2 KRT7 KRT5 KRT19 CEACAM5
32 hidrocystoma 29.4 PIP KRT7 KRT19 KRT15 CLEC2A CEACAM5
33 squamous cell carcinoma 29.3 KRT7 KRT19 KRT14 CEACAM5
34 keratosis, seborrheic 29.2 KRT7 KRT5 KRT17 KRT10 CLEC2A CEACAM5
35 keratoacanthoma 29.2 KRT17 KRT15 KRT14 KRT10
36 sweat gland cancer 29.1 PIP KRT7 KRT5 KRT19 KRT15 CLEC2A
37 eccrine papillary adenoma 29.1 PIP KRT17 KRT14 KRT10 CEACAM5
38 spindle cell carcinoma 29.0 KRT7 KRT5 KRT19 KRT14
39 skin benign neoplasm 28.9 PIP KRT7 KRT5 KRT14 CLEC2A
40 mucoepidermoid carcinoma 28.9 MAML2 KRT7 KRT5 KRT19 KRT14 CEACAM5
41 sweat gland benign neoplasm 28.8 PIP MAML2 KRT7 KRT5 KRT14 CLEC2A
42 basal cell carcinoma 27.9 KRT7 KRT5 KRT19 KRT17 KRT15 KRT14
43 papillary hidradenoma 12.7
44 vulvar nodular hidradenoma 12.2
45 squamous cell papilloma 10.5
46 rare tumor 10.5
47 mucoepidermoid esophageal carcinoma 10.5 KRT5 CEACAM5
48 breast cystic hypersecretory carcinoma 10.5 KRT5 CEACAM5
49 gallbladder squamous cell carcinoma 10.5 KRT5 CEACAM5
50 lipid-rich breast carcinoma 10.5 KRT5 CEACAM5

Graphical network of the top 20 diseases related to Eccrine Acrospiroma:



Diseases related to Eccrine Acrospiroma

Symptoms & Phenotypes for Eccrine Acrospiroma

MGI Mouse Phenotypes related to Eccrine Acrospiroma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 KRT14 KRT15 KRT17 KRT19 KRT5 PIP

Drugs & Therapeutics for Eccrine Acrospiroma

Search Clinical Trials , NIH Clinical Center for Eccrine Acrospiroma

Cochrane evidence based reviews: acrospiroma

Genetic Tests for Eccrine Acrospiroma

Anatomical Context for Eccrine Acrospiroma

MalaCards organs/tissues related to Eccrine Acrospiroma:

40
Skin, Breast, Bone, Colon, Bone Marrow, Lymph Node, Liver

Publications for Eccrine Acrospiroma

Articles related to Eccrine Acrospiroma:

(show top 50) (show all 474)
# Title Authors PMID Year
1
YAP1-MAML2-Rearranged Poroid Squamous Cell Carcinoma (Squamoid Porocarcinoma) Presenting as a Primary Parotid Gland Tumor. 61
32504288 2020
2
Eccrine Porocarcinoma with Zosteriform Metastasis. 61
32181102 2020
3
Dermatoscopy of the Borst-Jadassohn phenomenon in hidroacanthoma simplex. 61
31932162 2020
4
Poroma: A case report of pulsatile papule visualized on dermoscopy. 61
31893072 2019
5
Reactive epidermal eccrine proliferation on the foot due to lymphedema: Eccrine poroma or syringofibroadenoma? 61
31386224 2019
6
Dermoscopic features of nonpigmented eccrine poroma. 61
30677158 2019
7
Eccrine poromatosis following chemotherapy and radiation therapy. 61
32045152 2019
8
Dermoscopic-Histopathological Correlation of Eccrine Poroma: An Observational Study. 61
31723462 2019
9
[Pigmented eccrine poroma on the back]. 61
30910337 2019
10
A Painful Step - Pendulating Plantar Eccrine Poroma. 61
31850106 2019
11
Altered Rb, p16, and p53 expression is specific for porocarcinoma relative to poroma. 61
31012122 2019
12
Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma. 61
31145701 2019
13
The variegated dermoscopic features of pigmented eccrine poroma: a single institution experience. 61
31104461 2019
14
The Incidence of Nonmalignant Diseases among Patients with Suspected Carcinoma of Unknown Primary Site. 61
30713301 2019
15
The transition between a poroma and a porocarcinoma evidenced by the dermoscopy. 61
31090833 2019
16
Initial Misidentification of Thumb Poroma by Shave Biopsy. 61
30037763 2019
17
Eccrine poroma of the nipple: the first reported case. 61
30826784 2019
18
Poromas with large lumens histopathologically mimicking syringocystadenoma papilliferum: Report of three cases. 61
29943807 2019
19
Eccrine porocarcinoma on the cheek. 61
30739434 2019
20
Recurrent Metastatic Eccrine Porocarcinoma: A Case Report and Review of the Literature. 61
30739904 2019
21
Eccrine Poroma of the Vulva. 61
29293123 2019
22
Eccrine intraepidermal poroma of the eyelid. 61
30574914 2019
23
Monophasic sarcomatoid eccrine porocarcinoma. Report of a case and literature review. 61
31263860 2019
24
Dermatoscopy: an auxiliary resource for the diagnosis of poroid neoplasms. 61
30484540 2018
25
Eccrine poroma: Insights of its occurrence and differentials in the maxillofacial region. 61
30651691 2018
26
Dermoscopic features and patterns of poromas: a multicentre observational case-control study conducted by the International Dermoscopy Society. 61
29194789 2018
27
Cuticular Poroma: A Poroma Mostly Composed of Cuticular Cells (Cuticuloma). 61
29293126 2018
28
Multiple Eruptive Eccrine Poromas Associated with Chemotherapy and Autologous Bone Marrow Transplantation. 61
30050816 2018
29
Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells. 61
29436004 2018
30
Holocrine Poroma: A Distinctive Adnexal Tumor. 61
29095742 2018
31
Pigmented poroma on the temporal region dermoscopically mimicking basal cell carcinoma: A report of two cases. 61
29139150 2018
32
Eccrine Poroma with Rapid Growth during Pregnancy: A Case Report and Review of the Literature. 61
29606822 2018
33
Cytomorphology of Skin Adnexal Tumors: A Tale of Two Scalp Swellings. 61
29403175 2018
34
A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report. 61
29245095 2018
35
Periungual Eccrine Poroma Masquerading as Ingrown Toenails A Case Report with Dermoscopic Findings. 61
29252016 2017
36
Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature. 61
28831427 2017
37
[External nose eccrine poromaļ¼ša case report]. 61
29798176 2017
38
Reticulated acanthoma with sebaceous differentiation mimicking melanoma. 61
29085717 2017
39
Concomitant poroma and porocarcinoma. 61
28954110 2017
40
Large Eccrine Acrospiroma of the Hand. 61
28892973 2017
41
Clinicopathological analysis of 384 cases of poroid neoplasms including 98 cases of apocrine type cases. 61
27177596 2017
42
Eccrine poroma with calcification and metaplastic ossification. 61
27237046 2017
43
Eccrine Poroma of the Postauricular Area. 61
28913302 2017
44
Poroid Condyloma Versus Poroma With Atypias Because of Human Papillomavirus Infection. 61
28177975 2017
45
Vulvar eccrine porocarcinoma: report of a case and literature review. 61
29556664 2017
46
A Large Lumbar Adnexal Neoplasm Presenting Characteristics of Eccrine Poroma and Poroid Hidradenoma. 61
29057137 2017
47
An uncommon presentation of eccrine poroma. 61
27990401 2016
48
Eccrine poroma: correlation of reflectance confocal microscopy and histopathology of horizontal sections. 61
26551629 2016
49
Eccrine poroma: the great dermoscopic imitator. 61
26333195 2016
50
Pigmented eccrine poroma: dermoscopic and confocal features. 61
27648386 2016

Variations for Eccrine Acrospiroma

Expression for Eccrine Acrospiroma

Search GEO for disease gene expression data for Eccrine Acrospiroma.

Pathways for Eccrine Acrospiroma

Pathways related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 KRT77 KRT7 KRT5 KRT40 KRT19 KRT17
2
Show member pathways
12.39 KRT40 KRT19 KRT17 KRT15 KRT14 KRT10
3 12.25 KRT7 KRT5 KRT19 KRT17 KRT10
4
Show member pathways
11.73 KRT77 KRT7 KRT5 KRT40 KRT19 KRT17
5
Show member pathways
11.59 KRT7 KRT5 KRT19 KRT17 KRT14
6 11.49 KRT5 KRT17 KRT14
7 11.42 KRT40 KRT19 KRT17 KRT15 KRT14 KRT10

GO Terms for Eccrine Acrospiroma

Cellular components related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 PIP KRT77 KRT7 KRT5 KRT19 KRT15
2 cell periphery GO:0071944 9.43 KRT19 KRT17 KRT14
3 intermediate filament GO:0005882 9.28 KRT77 KRT7 KRT5 KRT40 KRT19 KRT17
4 keratin filament GO:0045095 9.26 KRT77 KRT7 KRT5 KRT14

Biological processes related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.61 KRT77 KRT7 KRT5 KRT40 KRT19 KRT17
2 epidermis development GO:0008544 9.43 KRT5 KRT15 KRT14
3 cornification GO:0070268 9.28 KRT77 KRT7 KRT5 KRT40 KRT19 KRT17
4 hemidesmosome assembly GO:0031581 9.16 KRT5 KRT14

Molecular functions related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.26 KRT5 KRT19 KRT15 KRT14
2 structural molecule activity GO:0005198 9.1 KRT40 KRT19 KRT17 KRT15 KRT14 KRT10

Sources for Eccrine Acrospiroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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