MCID: ECC002
MIFTS: 39

Eccrine Acrospiroma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Eccrine Acrospiroma

MalaCards integrated aliases for Eccrine Acrospiroma:

Name: Eccrine Acrospiroma 12 15 17 74
Poroma 12 17 74
Acrospiroma 45 74
Eccrine Hidradenoma of Skin 12
Adenoma, Sweat Gland 74
Eccrine Hidradenoma 12
Eccrine Poroma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5442
MeSH 45 D018250
NCIt 51 C7568
SNOMED-CT 69 81143000 81393009

Summaries for Eccrine Acrospiroma

MalaCards based summary : Eccrine Acrospiroma, also known as poroma, is related to keratosis and bowen's disease. An important gene associated with Eccrine Acrospiroma is LUM (Lumican), and among its related pathways/superpathways are Developmental Biology and Circadian entrainment. Affiliated tissues include skin, breast and liver, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and digestive/alimentary

Wikipedia : 77 Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. These are 1–3 cm translucent... more...

Related Diseases for Eccrine Acrospiroma

Diseases related to Eccrine Acrospiroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 keratosis 30.5 KRT10 KRT9
2 bowen's disease 30.5 KRT10 KRT17
3 acanthoma 30.2 KRT10 KRT17
4 keratosis, seborrheic 30.1 KRT10 KRT17 SALL1
5 sweat gland cancer 29.4 KRT15 TP53
6 basal cell carcinoma 29.3 KRT10 KRT15 KRT17 TP53
7 malignant acrospiroma 12.5
8 hidradenocarcinoma 12.0
9 acrospiroma 11.9
10 hidradenoma 11.8
11 clear cell hidradenoma 11.7
12 eccrine porocarcinoma 11.7
13 nodular hidradenoma 11.3
14 vulvar nodular hidradenoma 11.1
15 basal cell carcinoma, infundibulocystic 10.2 KRT10 KRT17
16 large cell acanthoma 10.2 KRT10 KRT17
17 steatocystoma multiplex 10.2 KRT10 KRT17
18 nodular malignant melanoma 10.2
19 melanoma 10.2
20 transitional cell carcinoma 10.2
21 papillary transitional carcinoma 10.2
22 palmoplantar keratoderma, bothnian type 10.2 KRT17 KRT9
23 inverted follicular keratosis 10.1 KRT17 SALL1
24 basal cell carcinoma 1 10.1
25 syringocystadenoma papilliferum 10.1
26 rere-related disorders 10.1
27 vulvar intraepithelial neoplasia 10.1 KRT10 TP53
28 vulva squamous cell carcinoma 10.1 KRT17 TP53
29 cervix uteri carcinoma in situ 10.1 KRT17 TP53
30 uterus carcinoma in situ 10.0 KRT17 TP53
31 breast squamous cell carcinoma 10.0 KRT10 TP53
32 nevus, epidermal 10.0
33 retinoblastoma 10.0
34 adenoma 10.0
35 palmoplantar keratoderma, epidermolytic 10.0 KRT10 KRT9
36 basaloid squamous cell carcinoma 10.0 KRT17 TP53
37 primary cutaneous amyloidosis 10.0 KRT10 KRT17
38 verrucous carcinoma 10.0 KRT10 TP53
39 pre-malignant neoplasm 10.0 KRT17 TP53
40 ampulla of vater cancer 10.0 KRT17 TP53
41 nodular basal cell carcinoma 10.0 KRT15 KRT17
42 pachyonychia congenita 1 10.0 KRT10 KRT17 KRT9
43 morpheaform basal cell carcinoma 10.0 KRT15 KRT17
44 epidermolytic hyperkeratosis 10.0 KRT10 KRT17 KRT9
45 pinguecula 9.9 KRT10 TP53
46 infiltrative basal cell carcinoma 9.9 KRT15 KRT17
47 in situ carcinoma 9.9 KRT17 TP53
48 actinic keratosis 9.9 KRT17 LUM TP53
49 basal cell nevus syndrome 9.9
50 breast cancer 9.9

Graphical network of the top 20 diseases related to Eccrine Acrospiroma:



Diseases related to Eccrine Acrospiroma

Symptoms & Phenotypes for Eccrine Acrospiroma

GenomeRNAi Phenotypes related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 EN1 KRT10 KRT9 SALL1

MGI Mouse Phenotypes related to Eccrine Acrospiroma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 KRT15 KRT17 LUM SALL1 TP53
2 limbs/digits/tail MP:0005371 9.26 EN1 LUM SALL1 TP53
3 pigmentation MP:0001186 8.8 EN1 KRT17 TP53

Drugs & Therapeutics for Eccrine Acrospiroma

Search Clinical Trials , NIH Clinical Center for Eccrine Acrospiroma

Cochrane evidence based reviews: acrospiroma

Genetic Tests for Eccrine Acrospiroma

Anatomical Context for Eccrine Acrospiroma

MalaCards organs/tissues related to Eccrine Acrospiroma:

42
Skin, Breast, Liver, Colon, Bone, Lymph Node, Eye

Publications for Eccrine Acrospiroma

Articles related to Eccrine Acrospiroma:

(show top 50) (show all 249)
# Title Authors Year
1
Altered RB, p16, or p53 expression is specific for porocarcinoma relative to poroma. ( 31012122 )
2019
2
Initial Misidentification of Thumb Poroma by Shave Biopsy. ( 30037763 )
2019
3
Eccrine intraepidermal poroma of the eyelid. ( 30574914 )
2019
4
Dermoscopic features of nonpigmented eccrine poroma. ( 30677158 )
2019
5
Eccrine poroma of the nipple: the first reported case. ( 30826784 )
2019
6
The transition between a poroma and a porocarcinoma evidenced by the dermoscopy. ( 31090833 )
2019
7
The variegated dermoscopic features of pigmented eccrine poroma: a single institution experience. ( 31104461 )
2019
8
Pigmented poroma on the temporal region dermoscopically mimicking basal cell carcinoma: A report of two cases. ( 29139150 )
2018
9
Holocrine Poroma: A Distinctive Adnexal Tumor. ( 29095742 )
2018
10
Cuticular Poroma: A Poroma Mostly Composed of Cuticular Cells (Cuticuloma). ( 29293126 )
2018
11
Eccrine Poroma with Rapid Growth during Pregnancy: A Case Report and Review of the Literature. ( 29606822 )
2018
12
Eccrine poroma: Insights of its occurrence and differentials in the maxillofacial region. ( 30651691 )
2018
13
Large Eccrine Acrospiroma of the Hand. ( 28892973 )
2017
14
A Large Lumbar Adnexal Neoplasm Presenting Characteristics of Eccrine Poroma and Poroid Hidradenoma. ( 29057137 )
2017
15
Poroid Condyloma Versus Poroma With Atypias Because of Human Papillomavirus Infection. ( 28177975 )
2017
16
Eccrine Poroma of the Postauricular Area. ( 28913302 )
2017
17
Concomitant poroma and porocarcinoma. ( 28954110 )
2017
18
Periungual Eccrine Poroma Masquerading as Ingrown Toenails A Case Report with Dermoscopic Findings. ( 29252016 )
2017
19
Eccrine Poroma of the Vulva. ( 29293123 )
2017
20
Eccrine poroma with calcification and metaplastic ossification. ( 27237046 )
2017
21
Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work. ( 26333057 )
2016
22
Pigmented eccrine poroma of the palm clinically mimicking a seborrheic keratosis. ( 27222880 )
2016
23
An uncommon presentation of eccrine poroma. ( 27990401 )
2016
24
Pigmented eccrine poroma: dermoscopic and confocal features. ( 27648386 )
2016
25
Malignant Eccrine Poroma of the Vulva: An Intriguing Case of a Rare Tumor at an Unusual Site. ( 27512190 )
2016
26
Eccrine Poroma Arising within Nevus Sebaceous. ( 27194975 )
2016
27
Pediatric Dermatology Photoquiz: An Ulcerated Nodule on the Abdomen of a Child. Eccrine poroma. ( 26758093 )
2016
28
Eccrine poroma: correlation of reflectance confocal microscopy and histopathology of horizontal sections. ( 26551629 )
2016
29
Eccrine poroma: the great dermoscopic imitator. ( 26333195 )
2016
30
Intraepidermal benign sebaceous neoplasm: apocrine poroma (hidroacanthoma simplex type) with extensive sebaceous differentiation with sebaceoma-like features. ( 26282586 )
2016
31
Cytological features of malignant eccrine acrospiroma presenting as a soft tissue mass axilla: A rare sweat gland tumor with histologic correlation. ( 26097826 )
2015
32
Nevus sebaceus with basal cell carcinoma, poroma, and verruca vulgaris. ( 26549086 )
2015
33
Merkel cell carcinoma arising within a poroma: report of two cases. ( 25732727 )
2015
34
Eccrine poroma on the helix: a rare anatomical presentation. ( 25831955 )
2015
35
An Unusual Clinical Presentation of Eccrine Poroma Occurring on the Auricle. ( 26538738 )
2015
36
A fleshy protuberant growth on the leg. Diagnosis: Eccrine poroma. ( 26515862 )
2015
37
Eccrine poroma and porocarcinoma on the same unusual location: report on two cases. ( 26312678 )
2015
38
Eccrine poroma. ( 26225348 )
2015
39
Case of pigmented eccrine poroma macroscopically simulated a malignant neoplasm with uptake of (18) F-fluorodeoxyglucose on positron emission tomography/computed tomography. ( 26046811 )
2015
40
Eccrine Poroma of the External Auditory Canal. ( 25923123 )
2015
41
Clinical and dermoscopic features of eccrine poroma. ( 25851755 )
2015
42
Periungual eccrine poroma. ( 25775671 )
2015
43
Poroma with sebaceous differentiation: dermoscopy for the diagnosis of skin tumor with sebaceous differentiation. ( 25657405 )
2015
44
Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. ( 24803063 )
2014
45
FDG PET/CT in malignant eccrine porocarcinoma arising in a pre-existing poroma. ( 23917787 )
2014
46
Collision tumor of eccrine poroma, seborrheic keratosis, and a viral wart. ( 25526344 )
2014
47
Eccrine poroma of the auricle: a case report. ( 25558412 )
2014
48
Periungual eccrine poroma. ( 25483134 )
2014
49
Pedunculated poroma on forearm: A rare clinical presentation. ( 25396131 )
2014
50
Poroma: a review of eccrine, apocrine, and malignant forms. ( 24697501 )
2014

Variations for Eccrine Acrospiroma

Expression for Eccrine Acrospiroma

Search GEO for disease gene expression data for Eccrine Acrospiroma.

Pathways for Eccrine Acrospiroma

Pathways related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 KRT10 KRT15 KRT17 KRT9 SALL1
2
Show member pathways
12.13 KRT10 KRT15 KRT17 KRT9
3
Show member pathways
11.38 KRT10 KRT15 KRT17 KRT9
4 11.17 KRT17 TP53

GO Terms for Eccrine Acrospiroma

Cellular components related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 KRT10 KRT15 KRT17 KRT9 LUM
2 intermediate filament GO:0005882 8.92 KRT10 KRT15 KRT17 KRT9

Biological processes related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.67 EN1 LUM SALL1 TP53
2 epidermis development GO:0008544 9.33 KRT15 KRT17 KRT9
3 limb development GO:0060173 9.32 EN1 SALL1
4 intermediate filament organization GO:0045109 9.26 KRT17 KRT9
5 keratinization GO:0031424 9.26 KRT10 KRT15 KRT17 KRT9
6 cornification GO:0070268 8.92 KRT10 KRT15 KRT17 KRT9

Molecular functions related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.13 EN1 SALL1 TP53
2 structural constituent of cytoskeleton GO:0005200 8.8 KRT15 KRT17 KRT9

Sources for Eccrine Acrospiroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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