MCID: ECC002
MIFTS: 34

Eccrine Acrospiroma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Eccrine Acrospiroma

MalaCards integrated aliases for Eccrine Acrospiroma:

Name: Eccrine Acrospiroma 12 15 73
Acrospiroma 44 73
Poroma 12 73
Eccrine Hidradenoma of Skin 12
Adenoma, Sweat Gland 73
Eccrine Hidradenoma 12
Eccrine Poroma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5442
MeSH 44 D018250
NCIt 50 C7568
SNOMED-CT 68 81143000 81393009

Summaries for Eccrine Acrospiroma

MalaCards based summary : Eccrine Acrospiroma, also known as acrospiroma, is related to keratosis and bowen's disease. An important gene associated with Eccrine Acrospiroma is LUM (Lumican), and among its related pathways/superpathways are Developmental Biology and Circadian entrainment. Affiliated tissues include skin, breast and eye, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and digestive/alimentary

Wikipedia : 76 Hidradenoma (also known as acrospiroma, from akral "peripheral" + spiroma "epithelial tumor of sweat... more...

Related Diseases for Eccrine Acrospiroma

Diseases related to Eccrine Acrospiroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 keratosis 30.3 KRT10 KRT9
2 bowen's disease 30.3 KRT10 KRT17
3 acanthoma 30.0 KRT10 KRT17
4 basal cell carcinoma 30.0 KRT10 KRT15 KRT17
5 keratosis, seborrheic 29.5 KRT10 KRT17 SALL1
6 malignant acrospiroma 12.4
7 hidradenocarcinoma 11.9
8 acrospiroma 11.9
9 hidradenoma 11.7
10 clear cell hidradenoma 11.6
11 eccrine porocarcinoma 11.6
12 nodular hidradenoma 11.3
13 vulvar nodular hidradenoma 11.1
14 nodular malignant melanoma 10.2
15 melanoma 10.2
16 transitional cell carcinoma 10.2
17 papillary transitional carcinoma 10.2
18 basal cell carcinoma, infundibulocystic 10.1 KRT10 KRT17
19 basal cell carcinoma 1 10.1
20 syringocystadenoma papilliferum 10.1
21 palmoplantar keratoderma, bothnian type 10.1 KRT17 KRT9
22 large cell acanthoma 10.1 KRT10 KRT17
23 steatocystoma multiplex 10.1 KRT10 KRT17
24 nevus, epidermal 10.0
25 nodular basal cell carcinoma 10.0 KRT15 KRT17
26 morpheaform basal cell carcinoma 10.0 KRT15 KRT17
27 keratoacanthoma 10.0 KRT10 KRT17
28 palmoplantar keratoderma, epidermolytic 10.0 KRT10 KRT9
29 infiltrative basal cell carcinoma 10.0 KRT15 KRT17
30 hidrocystoma 10.0 AZGP1 KRT15
31 primary cutaneous amyloidosis 10.0 KRT10 KRT17
32 pachyonychia congenita 1 10.0 KRT10 KRT17 KRT9
33 epidermolytic hyperkeratosis 10.0 KRT10 KRT17 KRT9
34 inverted follicular keratosis 10.0 KRT17 SALL1
35 actinic keratosis 9.9 KRT17 LUM
36 eccrine sweat gland neoplasm 9.9 KRT10 KRT15 KRT17
37 systemic lupus erythematosus 9.9
38 retinoblastoma 9.9
39 pulmonary alveolar microlithiasis 9.9
40 rothmund-thomson syndrome 9.9
41 cervical cancer 9.9
42 acute leukemia 9.9
43 leukemia 9.9
44 clear cell acanthoma 9.9
45 syringoma 9.9
46 porokeratosis 9.9
47 merkel cell carcinoma 9.9
48 amelanotic melanoma 9.9
49 sebaceous adenocarcinoma 9.9
50 spiradenoma 9.9

Graphical network of the top 20 diseases related to Eccrine Acrospiroma:



Diseases related to Eccrine Acrospiroma

Symptoms & Phenotypes for Eccrine Acrospiroma

GenomeRNAi Phenotypes related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 EN1 KRT10 KRT9 SALL1

MGI Mouse Phenotypes related to Eccrine Acrospiroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 KRT15 KRT17 LUM SALL1

Drugs & Therapeutics for Eccrine Acrospiroma

Search Clinical Trials , NIH Clinical Center for Eccrine Acrospiroma

Cochrane evidence based reviews: acrospiroma

Genetic Tests for Eccrine Acrospiroma

Anatomical Context for Eccrine Acrospiroma

MalaCards organs/tissues related to Eccrine Acrospiroma:

41
Skin, Breast, Eye

Publications for Eccrine Acrospiroma

Articles related to Eccrine Acrospiroma:

(show all 32)
# Title Authors Year
1
Large Eccrine Acrospiroma of the Hand. ( 28892973 )
2017
2
Cytological features of malignant eccrine acrospiroma presenting as a soft tissue mass axilla: A rare sweat gland tumor with histologic correlation. ( 26097826 )
2015
3
Malignant acrospiroma of chest and abdominal wall treated with chemotherapy. ( 23723491 )
2013
4
Malignant eccrine acrospiroma: a case report. ( 22659768 )
2012
5
Dermoscopy of eccrine acrospiroma masquerading as nodular malignant melanoma. ( 21390477 )
2010
6
Eccrine acrospiroma of inguinal area: Computed tomography findings. ( 16628036 )
2006
7
Eccrine acrospiroma of breast: mammographic and ultrasound findings. ( 15556599 )
2004
8
Giant eccrine acrospiroma: A case report and review of the literature. ( 24115850 )
2003
9
MR imaging appearance of plantar eccrine acrospiroma (sweat gland tumor). ( 12239078 )
2002
10
Malignant eccrine acrospiroma with metastasis to the parotid. ( 12025008 )
2002
11
Fine needle aspiration cytology of eccrine acrospiroma. ( 11726107 )
2001
12
Papillary transitional cell carcinoma of the breast: a report of five cases with distinction from eccrine acrospiroma. ( 10102614 )
1999
13
A rare case of atypical eccrine acrospiroma of the scalp and a literature review. ( 10340869 )
1999
14
Stump the experts. Eccrine acrospiroma, clear cell type. ( 9078309 )
1996
15
Recurrent eccrine acrospiroma of the hand. ( 8732420 )
1996
16
Malignant eccrine acrospiroma. A case study. ( 7877107 )
1995
17
Malignant eccrine acrospiroma of the breast. ( 7790144 )
1995
18
Eccrine acrospiroma in a young African male: case report. ( 7498053 )
1995
19
Stump the experts. Eccrine acrospiroma. ( 7798408 )
1994
20
A painlessly enlarging scalp nodule. Eccrine acrospiroma. ( 1316104 )
1992
21
Eccrine acrospiroma of the external auditory canal. ( 1310268 )
1992
22
Eccrine acrospiroma (clear cell hidradenoma) of the eyelid. Immunohistochemical and ultrastructural features. ( 1708858 )
1991
23
Eccrine acrospiroma of the eyelid with oncocytic, apocrine and sebaceous differentiation. Further evidence for pluripotentiality of the adnexal epithelia. ( 1668223 )
1991
24
Eccrine acrospiroma of eye lid--a case report. ( 1964930 )
1990
25
Giant eccrine acrospiroma. ( 2172332 )
1990
26
Stump the experts. Eccrine acrospiroma. ( 2556463 )
1989
27
Eccrine acrospiroma. ( 6096424 )
1984
28
Malignant eccrine acrospiroma. A case report. ( 6282887 )
1982
29
Pigmented eccrine acrospiroma. Report of a case. ( 6271077 )
1981
30
Large eccrine acrospiroma of the nose. ( 218664 )
1979
31
Eccrine acrospiroma (porosyringoma) of the eyelid. ( 4191805 )
1970
32
Eccrine acrospiroma. A clinicopathologic study. ( 5775301 )
1969

Variations for Eccrine Acrospiroma

Expression for Eccrine Acrospiroma

Search GEO for disease gene expression data for Eccrine Acrospiroma.

Pathways for Eccrine Acrospiroma

Pathways related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 KRT10 KRT15 KRT17 KRT9 SALL1
2
Show member pathways
12.13 KRT10 KRT15 KRT17 KRT9
3
Show member pathways
11.38 KRT10 KRT15 KRT17 KRT9

GO Terms for Eccrine Acrospiroma

Cellular components related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.43 AZGP1 KRT10 KRT15 KRT17 KRT9 LUM
2 intermediate filament GO:0005882 8.92 KRT10 KRT15 KRT17 KRT9

Biological processes related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.33 KRT15 KRT17 KRT9
2 limb development GO:0060173 9.32 EN1 SALL1
3 intermediate filament organization GO:0045109 9.26 KRT17 KRT9
4 keratinization GO:0031424 9.26 KRT10 KRT15 KRT17 KRT9
5 cornification GO:0070268 8.92 KRT10 KRT15 KRT17 KRT9

Molecular functions related to Eccrine Acrospiroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 KRT15 KRT17 KRT9

Sources for Eccrine Acrospiroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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