MCID: ECC001
MIFTS: 32

Eccrine Papillary Adenocarcinoma

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Eccrine Papillary Adenocarcinoma

MalaCards integrated aliases for Eccrine Papillary Adenocarcinoma:

Name: Eccrine Papillary Adenocarcinoma 12 15 70
Digital Papillary Eccrine Carcinoma of Skin 70
Digital Papillary Adenocarcinoma 12
Sweat Gland Adenocarcinoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5591
SNOMED-CT 67 128898008
UMLS 70 C0334344 C1367774 C1367789

Summaries for Eccrine Papillary Adenocarcinoma

MalaCards based summary : Eccrine Papillary Adenocarcinoma, also known as digital papillary eccrine carcinoma of skin, is related to papillary adenocarcinoma and papillary adenoma. An important gene associated with Eccrine Papillary Adenocarcinoma is MYBL1 (MYB Proto-Oncogene Like 1), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include breast, skin and prostate, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Eccrine Papillary Adenocarcinoma

Diseases related to Eccrine Papillary Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 365)
# Related Disease Score Top Affiliating Genes
1 papillary adenocarcinoma 30.8 PIP PGR KRT7 KRT19 CEACAM5
2 papillary adenoma 30.8 KRT7 KRT5 CEACAM5
3 spiradenoma 30.3 KRT7 KRT14
4 adenocarcinoma 30.2 KRT7 KLK3 FGFR2 CEACAM5
5 hidradenoma 30.1 PIP KRT7 KRT5 CEACAM5
6 papillary carcinoma 30.0 PGR KRT7 KRT19
7 epithelial-myoepithelial carcinoma 29.7 KRT7 KRT14
8 cystadenoma 29.6 PGR KRT7 KLK3 CEACAM5
9 hidrocystoma 29.2 PIP KRT8 KRT7 KRT19 CEACAM5
10 sweat gland cancer 29.1 PIP PGR KRT8 KRT7 KRT5 KRT19
11 eccrine sweat gland neoplasm 28.7 PIP KRT7 KRT5 KRT19 KRT14 KRT10
12 basal cell carcinoma 28.6 KRT8 KRT7 KRT5 KRT19 KRT14 KRT10
13 eccrine papillary adenoma 27.9 PIP PDPN KRT8 KRT7 KRT5 KRT19
14 aggressive digital papillary adenocarcinoma 11.7
15 rare tumor 10.5
16 lipid-rich breast carcinoma 10.4 PGR KRT5
17 basaloid lung carcinoma 10.4 PGR KRT5
18 fallopian tube endometriosis 10.4 PGR CEACAM5
19 pregnancy adenoma 10.4 PGR KRT5
20 granulomatous endometritis 10.4 PGR CEACAM5
21 vaginal glandular tumor 10.4 PGR CEACAM5
22 cervical serous adenocarcinoma 10.4 PGR CEACAM5
23 mucoepidermoid esophageal carcinoma 10.4 KRT5 CEACAM5
24 breast adenoid cystic carcinoma 10.4 PGR MYBL1
25 mucocele of appendix 10.4 PGR CEACAM5
26 bartholin's gland adenoid cystic carcinoma 10.4 PGR KRT7
27 breast papillary carcinoma 10.4 PGR KRT5
28 breast cystic hypersecretory carcinoma 10.4 KRT5 CEACAM5
29 ureter squamous cell carcinoma 10.4 KRT7 KRT5
30 gallbladder squamous cell carcinoma 10.3 KRT5 CEACAM5
31 thymus adenocarcinoma 10.3 KRT5 CEACAM5
32 vulva basal cell carcinoma 10.3 KRT5 CEACAM5
33 inverted transitional papilloma 10.3 KRT7 KRT5
34 leukoplakia of penis 10.3 KRT7 CEACAM5
35 lung adenoid cystic carcinoma 10.3 MYBL1 KRT7
36 ovarian seromucinous carcinoma 10.3 PGR KRT7
37 liver leiomyoma 10.3 PGR CEACAM5
38 auditory system benign neoplasm 10.3 KRT7 KRT5
39 colon leiomyosarcoma 10.3 KRT5 CEACAM5
40 microinvasive cervical squamous cell carcinoma 10.3 KRT7 KRT5
41 benign metastasizing leiomyoma 10.3 PGR KRT7
42 mucinous adenofibroma 10.3 KRT7 CEACAM5
43 pancreatic foamy gland adenocarcinoma 10.3 KRT7 CEACAM5
44 breast sarcoma 10.3 PGR KRT5
45 breast malignant phyllodes tumor 10.3 PGR KRT5
46 lung clear cell carcinoma 10.3 KRT7 KRT5
47 pancreatic serous cystadenocarcinoma 10.3 KRT7 CEACAM5
48 urinary bladder villous adenoma 10.3 KRT7 CEACAM5
49 vaginal tubulovillous adenoma 10.3 KRT7 CEACAM5
50 necrotizing sialometaplasia 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Eccrine Papillary Adenocarcinoma:



Diseases related to Eccrine Papillary Adenocarcinoma

Symptoms & Phenotypes for Eccrine Papillary Adenocarcinoma

GenomeRNAi Phenotypes related to Eccrine Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.1 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.1 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.1 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.1 KRT5 KRT7 KRT8

MGI Mouse Phenotypes related to Eccrine Papillary Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 FGFR2 KRT14 KRT19 KRT5 KRT8 PDPN
2 immune system MP:0005387 9.61 FGFR2 KRT14 KRT19 KRT5 KRT8 MYBL1
3 integument MP:0010771 9.17 FGFR2 KRT14 KRT19 KRT5 MYBL1 PDPN

Drugs & Therapeutics for Eccrine Papillary Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Eccrine Papillary Adenocarcinoma

Genetic Tests for Eccrine Papillary Adenocarcinoma

Anatomical Context for Eccrine Papillary Adenocarcinoma

MalaCards organs/tissues related to Eccrine Papillary Adenocarcinoma:

40
Breast, Skin, Prostate, Lung, Colon, Liver, Appendix

Publications for Eccrine Papillary Adenocarcinoma

Articles related to Eccrine Papillary Adenocarcinoma:

(show all 36)
# Title Authors PMID Year
1
Estrogen and progesterone receptors and anti-gross cystic disease fluid protein 15 (BRST-2) fail to distinguish metastatic breast carcinoma from eccrine neoplasms. 54 61
8751328 1995
2
An Update on Endocrine Mucin-producing Sweat Gland Carcinoma: Clinicopathologic Study of 63 Cases and Comparative Analysis. 61
32452870 2020
3
Head and neck sweat gland adenocarcinoma: A population-based perspective of a rare entity. 61
28397272 2017
4
Apocrine sweat gland adenocarcinoma: A rare case report and review. 61
28550787 2017
5
Metastatic Invasive Sweat Gland Adenocarcinoma of the Hand with Upper Limb Amputation/Shoulder Reconstruction. 61
26495225 2015
6
Sweat gland adenocarcinoma of scalp. 61
24778534 2013
7
Late lung metastasis of a primary eccrine sweat gland carcinoma 10 years after initial surgical treatment: the first clinical documentation. 61
23710393 2013
8
Anogenital sweat gland adenocarcinoma of the vulva: a diagnostic conundrum. 61
22407069 2012
9
Metastatic apocrine sweat gland adenocarcinoma in a terrier dog. 61
23569992 2012
10
Clinicopathologic characteristics of extramammary Paget's disease of the scrotum associated with sweat gland adenocarcinoma-a clinical retrospective study. 61
21463849 2011
11
Early-stage mucinous sweat gland adenocarcinoma of eyelid. 61
21629575 2011
12
Mucinous sweat gland adenocarcinoma of the eyelid - current knowledge of a rare tumor. 61
21158574 2010
13
Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma. 61
20606537 2010
14
Immunolocalization of Epstein-Barr virus-related antigens in a case of sweat gland adenocarcinoma. 61
19558594 2009
15
[Extramammary Paget's disease of the scrotum with underlying sweat gland adenocarcinoma: a report of six cases with literature review]. 61
19664337 2009
16
Eccrine porocarcinoma: Report of a case with fine needle aspiration cytology, histopathology and immunohistochemistry. 61
16901019 2006
17
Eccrine porocarcinoma of the upper eyelid. 61
16197432 2005
18
Successful adjuvant tamoxifen therapy for estrogen receptor-positive metastasizing sweat gland adenocarcinoma: need for a clinical trial? 61
15053210 2004
19
Metastatic sweat gland adenocarcinoma: A clinico-pathological dilemma. 61
12921537 2003
20
Metastatic sweat gland carcinoma. 61
11762625 2001
21
Paratrichial sweat gland adenocarcinoma in a marmoset. 61
12968767 1999
22
[Polymorphic sweat gland adenocarcinoma of low grade of malignancy]. 61
9090934 1996
23
Flow cytometric DNA analysis of extramammary Paget's disease of the vulva. 61
8598335 1995
24
Mixed apocrine (sweat gland) adenocarcinoma in the tail of a cow. 61
8059513 1994
25
Mucinous sweat-gland adenocarcinoma of the eyelid. 61
1477644 1992
26
Disseminated sweat gland adenocarcinoma with acronecrosis in a cat. 61
2029842 1991
27
Cancer of the auricle. 61
2168270 1990
28
Fine needle aspiration biopsy in the diagnosis of apocrine sweat gland adenocarcinoma. 61
2321463 1990
29
Mucinous sweat-gland adenocarcinoma of the inner canthus: a case report. 61
3408083 1988
30
Vulvar Paget's disease with an underlying sweat gland adenocarcinoma. 61
2834426 1988
31
Mucinous eccrine sweat gland adenocarcinoma of the eyelid. 61
2832041 1988
32
Anti-tumor evaluation of benzaldehyde in the dog and cat. 61
3954233 1986
33
Mucinous adenocarcinoma of the eyelid. A case report. 61
6329149 1984
34
Ocular manifestations of metastatic sweat gland adenocarcinoma in a cat. 61
7085480 1982
35
Mucinous sweat gland adenocarcinoma of the eyelid. 61
7270630 1981
36
Mucinous sweat gland adenocarcinoma of eyelid: a clinicopathologic study of 21 cases with histochemical and electron microscopic observations. 61
227576 1979

Variations for Eccrine Papillary Adenocarcinoma

Expression for Eccrine Papillary Adenocarcinoma

Search GEO for disease gene expression data for Eccrine Papillary Adenocarcinoma.

Pathways for Eccrine Papillary Adenocarcinoma

Pathways related to Eccrine Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 KRT8 KRT7 KRT5 KRT19 KRT14 KRT10
2 12.12 PDPN KRT8 KRT7 KRT5 KRT19 KRT10
3
Show member pathways
11.89 KRT8 KRT7 KRT5 KRT19 KRT14 KRT10
4 11.7 PGR KRT19 KRT14 KRT10
5 11.53 KRT19 KRT14 KRT10
6
Show member pathways
11.05 KRT8 KRT7 KRT5 KRT19 KRT14

GO Terms for Eccrine Papillary Adenocarcinoma

Cellular components related to Eccrine Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.61 PIP KRT8 KRT7 KRT5 KRT19 KRT14
2 keratin filament GO:0045095 9.46 KRT8 KRT7 KRT5 KRT14
3 cell periphery GO:0071944 9.43 KRT8 KRT19 KRT14
4 apicolateral plasma membrane GO:0016327 9.4 KRT8 KRT19
5 costamere GO:0043034 9.37 KRT8 KRT19
6 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT8 KRT19
7 intermediate filament GO:0005882 9.1 KRT8 KRT7 KRT5 KRT19 KRT14 KRT10

Biological processes related to Eccrine Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.43 KRT8 KRT7 KRT5 KRT19 KRT14 KRT10
2 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
3 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19
4 cornification GO:0070268 9.1 KRT8 KRT7 KRT5 KRT19 KRT14 KRT10

Molecular functions related to Eccrine Papillary Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 KRT5 KRT19 KRT14

Sources for Eccrine Papillary Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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