MCID: ECC003
MIFTS: 36

Eccrine Papillary Adenoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Eccrine Papillary Adenoma

MalaCards integrated aliases for Eccrine Papillary Adenoma:

Name: Eccrine Papillary Adenoma 12 15 70
Papillary Eccrine Adenoma 12 20
Eccrine Papillary Adenoma of Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5446
NCIt 50 C4173
SNOMED-CT 67 253021007
UMLS 70 C0334350

Summaries for Eccrine Papillary Adenoma

Disease Ontology : 12 A eccrine sweat gland neoplasm that is characterized by isolated well-circumscribed dermal nodule existent for a prolonged duration of time.

MalaCards based summary : Eccrine Papillary Adenoma, also known as papillary eccrine adenoma, is related to apocrine adenoma and adenoma. An important gene associated with Eccrine Papillary Adenoma is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include breast, skin and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Papillary eccrine adenoma is a cutaneous condition characterized by an uncommon benign sweat gland... more...

Related Diseases for Eccrine Papillary Adenoma

Diseases related to Eccrine Papillary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 380)
# Related Disease Score Top Affiliating Genes
1 apocrine adenoma 31.0 PIP KRAS
2 adenoma 30.6 PLAG1 PIK3CA KRT7 KRAS
3 syringocystadenoma papilliferum 30.5 PIP KRT19 KRAS
4 syringoma 30.5 PLAG1 KRT7 KRT19 CEACAM5
5 papillary adenocarcinoma 29.9 PIP KRT7 KRT19 KRAS CEACAM5
6 hidradenoma 29.9 PIP PIK3CA KRT7 KRT5 KRT15 CEACAM5
7 skin benign neoplasm 29.9 PIP KRT7 KRT5 KRT14 HRAS
8 sweat gland cancer 29.7 PIP KRT8 KRT7 KRT5 KRT19 KRT15
9 keratosis 29.1 PIK3CA KRT9 KRT5 KRT17 KRT16 KRT14
10 fox-fordyce disease 10.4 PIP CEACAM5
11 vulvar eccrine porocarcinoma 10.4 PIP CEACAM5
12 laryngeal mucoepidermoid carcinoma 10.4 KRT14 CEACAM5
13 leukoplakia of penis 10.4 KRT7 CEACAM5
14 urethral villous adenoma 10.4 KRT7 CEACAM5
15 glycogen-rich clear cell breast carcinoma 10.4 PIP KRT14
16 mucinous adenofibroma 10.4 KRT7 CEACAM5
17 anal canal paget's disease 10.4 PIP KRT7
18 gastric signet ring cell adenocarcinoma 10.4 PIP KRT7
19 pancreatic foamy gland adenocarcinoma 10.4 KRT7 CEACAM5
20 idiopathic corneal edema 10.4 KRT8 KRT19
21 pancreatic serous cystadenocarcinoma 10.4 KRT7 CEACAM5
22 urinary bladder villous adenoma 10.4 KRT7 CEACAM5
23 bartholin's gland disease 10.4 PIP KRT7
24 vaginal tubulovillous adenoma 10.4 KRT7 CEACAM5
25 endolymphatic sac tumor 10.4 KRT8 KRT7
26 bartholin's gland carcinoma 10.4 PIP KRT7
27 female urethral cancer 10.4 KRT7 CEACAM5
28 bile duct cystadenocarcinoma 10.4 KRT7 CEACAM5
29 mucinous ovarian cystadenoma 10.4 KRT7 CEACAM5
30 krukenberg carcinoma 10.4 KRT7 CEACAM5
31 eyelid carcinoma 10.4 PIP KRT7
32 adenoid basal cell carcinoma 10.4 KRT7 CEACAM5
33 nodular hidradenoma 10.4 PIP KRT10 CEACAM5
34 biliary papillomatosis 10.4 KRT7 CEACAM5
35 paratesticular lipoma 10.4 KRT19 CEACAM5
36 lipoma of spermatic cord 10.4 KRT19 CEACAM5
37 bartholin's duct cyst 10.4 PLAG1 PIP
38 synovium neoplasm 10.4 KRT8 KRT7
39 median rhomboid glossitis 10.3 KRT17 KRT16
40 polyp of corpus uteri 10.3 KRT8 KRT14
41 follicular infundibulum tumor 10.3 KRT17 KRT15
42 vulva adenocarcinoma 10.3 PIP KRT7 CEACAM5
43 vulval paget's disease 10.3 PIP KRT7 CEACAM5
44 gastric diffuse adenocarcinoma 10.3 PIP KRT7 CEACAM5
45 linitis plastica 10.3 PIP KRT7 CEACAM5
46 pachyonychia congenita 2 10.3 KRT17 KRT16
47 thyroid hurthle cell adenoma 10.3 PIK3CA KRT14
48 oncocytic breast carcinoma 10.3 PIP KRT7 KRT14
49 focal palmoplantar keratoderma 10.3 KRT17 KRT16
50 peritoneal serous adenocarcinoma 10.3 PIP KRT7 KRT17

Graphical network of the top 20 diseases related to Eccrine Papillary Adenoma:



Diseases related to Eccrine Papillary Adenoma

Symptoms & Phenotypes for Eccrine Papillary Adenoma

GenomeRNAi Phenotypes related to Eccrine Papillary Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.44 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.44 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.44 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.44 KRT18
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.44 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.44 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.44 KRT18
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 KRT18 KRT5 KRT7 KRT8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.44 KRT18

MGI Mouse Phenotypes related to Eccrine Papillary Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.76 HRAS KRAS KRT14 KRT16 KRT17 KRT19
2 digestive/alimentary MP:0005381 9.7 HRAS KRAS KRT14 KRT15 KRT16 KRT17
3 integument MP:0010771 9.32 HRAS KRAS KRT14 KRT16 KRT17 KRT19

Drugs & Therapeutics for Eccrine Papillary Adenoma

Search Clinical Trials , NIH Clinical Center for Eccrine Papillary Adenoma

Genetic Tests for Eccrine Papillary Adenoma

Anatomical Context for Eccrine Papillary Adenoma

MalaCards organs/tissues related to Eccrine Papillary Adenoma:

40
Breast, Skin, Lung, Colon, Liver, Thyroid, Ovary

Publications for Eccrine Papillary Adenoma

Articles related to Eccrine Papillary Adenoma:

(show all 43)
# Title Authors PMID Year
1
Papillary eccrine adenoma associated with syringocystadenoma papilliferum. 61
29582790 2018
2
BRAF and KRAS mutations in tubular apocrine adenoma and papillary eccrine adenoma of the skin. 61
29241739 2018
3
Papillary adenocarcinoma in situ of the skin: report of four cases. 61
24855569 2014
4
Papillary eccrine adenoma should not be mistaken for aggressive digital papillary adenocarcinoma. 61
24274672 2014
5
Papillary eccrine adenoma in association with cutaneous horn. 61
17492846 2007
6
Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases. 61
16625077 2006
7
Papillary eccrine adenoma. 61
17642667 2004
8
Mixed tubulopapillary hidradenoma and syringocystadenoma papilliferum occurring as a verrucous tumor. 61
12641782 2003
9
Mohs micrographic surgery of a papillary eccrine adenoma. 61
12472500 2002
10
Papillary eccrine adenoma of the heel: a case report. 61
10949805 2000
11
Mixed syringocystadenoma papilliferum and papillary eccrine adenoma occurring in a scrotal condyloma. 61
10774942 2000
12
Papillary eccrine adenoma: an ultrastructural and immunohistochemical study. 61
9793207 1998
13
Staining of eccrine and apocrine neoplasms and metastatic adenocarcinoma with IKH-4, a monoclonal antibody specific for the eccrine gland. 61
9521499 1998
14
Papillary eccrine adenoma: immunohistochemical study and literature review. 61
9508346 1998
15
Papillary eccrine adenoma with a pomegranate-like appearance. 61
9492441 1997
16
Papillary eccrine adenoma: immunohistochemical studies of keratin expression. 61
9404854 1997
17
Diagnostic significance of the myoepithelial cells in the benign and malignant sweat gland tumors. 61
8705271 1996
18
Tubular apocrine adenoma with eccrine and apocrine immunophenotypes or papillary tubular adenoma? 61
8599457 1995
19
Papillary eccrine adenoma--a case of cutaneous sweat gland tumor with secretory and ductular differentiation. 61
7697336 1994
20
Is tubular apocrine adenoma a distinct clinical entity? 61
8238787 1993
21
Papillary tubular adenoma of the skin. 61
8340538 1993
22
Papillary eccrine adenoma. A case report with immunohistochemical examination. 61
8494116 1993
23
Myoepithelial differentiation in benign sweat gland tumors. Demonstrated by a monoclonal antibody to alpha-smooth muscle actin. 61
1331211 1992
24
Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? 61
1566975 1992
25
Recent advances and controversies concerning adnexal neoplasms. 61
1309688 1992
26
Papillary eccrine adenoma. A histopathological and immunohistochemical study. 61
2013355 1991
27
Papillary eccrine adenoma--a light-microscopic and immunohistochemical study. 61
2279339 1990
28
Papillary eccrine adenoma. Immunohistochemical and ultrastructural analyses. 61
2100547 1990
29
[Immunohistochemical studies of normal sweat glands, sweat gland tumors and extramammary Paget's diseases. II. Immunohistochemical studies of sweat gland tumors and extramammary Paget's diseases]. 61
2165191 1990
30
[An immunohistochemical study of cutaneous tumors using an antibody to the breast cyst fluid protein (GCDFP-15)]. 61
2689727 1989
31
Papillary eccrine adenoma: an electron microscopic study. 61
2754059 1989
32
[Sweat gland tumors in Niger. Anatomopathology]. 61
2556957 1989
33
[Papillary eccrine adenoma]. 61
2666801 1989
34
Papillary eccrine adenoma. A light microscopic and immunohistochemical study. 61
3290282 1988
35
Papillary eccrine adenoma. 61
2853581 1988
36
Papillary eccrine adenoma. Light-microscopic, histochemical, and immunohistochemical studies. 61
3631452 1987
37
Malignant transformation of eccrine tumors. 61
3031140 1987
38
Papillary eccrine adenoma. A tubulopapillary hidradenoma with eccrine differentiation. 61
3518523 1986
39
Papillary eccrine adenoma. 61
6546338 1984
40
Papillary eccrine adenoma. 61
7120491 1982
41
Papillary eccrine adenoma. 61
7377809 1980
42
Papillary eccrine adenoma. 61
677931 1978
43
Papillary eccrine adenoma. 61
857729 1977

Variations for Eccrine Papillary Adenoma

Expression for Eccrine Papillary Adenoma

Search GEO for disease gene expression data for Eccrine Papillary Adenoma.

Pathways for Eccrine Papillary Adenoma

Pathways related to Eccrine Papillary Adenoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 PIK3CA KRT9 KRT8 KRT7 KRT5 KRT19
2 12.46 PDPN KRT8 KRT7 KRT5 KRT19 KRT18
3
Show member pathways
12.15 KRT9 KRT8 KRT7 KRT5 KRT19 KRT18
4
Show member pathways
12.01 PIK3CA KRAS HRAS CEACAM5
5
Show member pathways
11.89 KRT8 KRT7 KRT5 KRT19 KRT18 KRT17
6 11.74 KRT9 KRT19 KRT18 KRT17 KRT16 KRT15
7
Show member pathways
11.73 PIK3CA KRAS HRAS
8
Show member pathways
11.71 PIK3CA KRAS HRAS
9 11.66 KRT5 KRT17 KRT14
10
Show member pathways
11.65 PIK3CA KRAS HRAS
11 11.58 PIK3CA KRAS HRAS
12 11.56 PIK3CA KRAS HRAS
13 11.55 PIK3CA KRAS HRAS
14 11.53 PIK3CA KRAS HRAS
15 11.5 PIK3CA KRAS HRAS
16 11.5 PIK3CA KRT9 KRT19 KRT18 KRT17 KRT16
17 11.46 PIK3CA KRAS HRAS
18 11.09 PIK3CA KRAS HRAS
19 11.06 MFGE8 KRAS HRAS
20 10.7 KRAS HRAS

GO Terms for Eccrine Papillary Adenoma

Cellular components related to Eccrine Papillary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.22 PLAG1 PIK3CA PDPN KRT9 KRT8 KRT7
2 extracellular exosome GO:0070062 9.77 PIP MFGE8 KRT9 KRT8 KRT7 KRT5
3 keratin filament GO:0045095 9.65 KRT8 KRT7 KRT5 KRT18 KRT14
4 cell periphery GO:0071944 9.55 KRT8 KRT19 KRT18 KRT17 KRT14
5 intermediate filament GO:0005882 9.36 KRT9 KRT8 KRT7 KRT5 KRT19 KRT18

Biological processes related to Eccrine Papillary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 PLAG1 PIP KRAS HRAS HMGA2
2 cornification GO:0070268 9.7 KRT9 KRT8 KRT7 KRT5 KRT19 KRT18
3 liver development GO:0001889 9.63 PIK3CA KRAS HRAS
4 epidermis development GO:0008544 9.46 KRT9 KRT5 KRT15 KRT14
5 hemidesmosome assembly GO:0031581 9.43 KRT5 KRT14
6 hepatocyte apoptotic process GO:0097284 9.37 KRT8 KRT18
7 keratinization GO:0031424 9.36 KRT9 KRT8 KRT7 KRT5 KRT19 KRT18
8 response to isolation stress GO:0035900 9.32 KRAS HRAS
9 cell differentiation involved in embryonic placenta development GO:0060706 9.26 KRT8 KRT19

Molecular functions related to Eccrine Papillary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 9.46 KRT8 KRT5 KRT18 KRT15
2 structural constituent of cytoskeleton GO:0005200 9.43 KRT9 KRT5 KRT19 KRT16 KRT15 KRT14
3 structural molecule activity GO:0005198 9.23 KRT9 KRT19 KRT18 KRT17 KRT16 KRT15

Sources for Eccrine Papillary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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