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MCID: ECC004
MIFTS: 42

Eccrine Porocarcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Eccrine Porocarcinoma

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MalaCards integrated aliases for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma 12 20 54 44 15 17 71
Eccrine Porocarcinoma of Skin 12 20
Malignant Eccrine Poroma 12 20
Porocarcinoma 12 20

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7566
MeSH 44 D057090
NCIt 50 C5560
SNOMED-CT 67 254708001
UMLS 71 C1266065
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Summaries for Eccrine Porocarcinoma

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GARD : 20 Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). They are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. Most people with an eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. Factors that may increase the risk to develop an eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation. Treatment usually involves surgery to remove the tumor.

MalaCards based summary : Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to vulvar eccrine porocarcinoma and myoepithelioma. An important gene associated with Eccrine Porocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. Affiliated tissues include skin and lymph node, and related phenotype is integument.

Wikipedia : 74 A malignant acrospiroma is a sweat gland carcinoma of the hand, which may recur locally in 50% of... more...

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Related Diseases for Eccrine Porocarcinoma

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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 400)
# Related Disease Score Top Affiliating Genes
1 vulvar eccrine porocarcinoma 32.4 MUC1 CEACAM5
2 myoepithelioma 30.1 VIM S100B MUC1
3 eccrine acrospiroma 30.1 NUTM1 KRT7 KRT5 KRT19 CEACAM5
4 lymphangioma 30.1 VIM STAT3 CEACAM5
5 acanthoma 29.9 KRT5 KRT1
6 sweat gland benign neoplasm 29.8 KRT7 KRT5 CEACAM5
7 villous adenoma 29.8 MUC1 KRT7 CEACAM5
8 skin benign neoplasm 29.7 STAT3 KRT7 KRT5 KRT1
9 sweat gland cancer 29.7 KRT7 KRT5 KRT19 CEACAM5
10 eccrine papillary adenocarcinoma 29.6 KRT7 KRT5 KRT19 CEACAM5
11 eccrine adenocarcinoma 29.6 KRT7 KRT5 CEACAM5
12 sarcomatoid carcinoma 29.6 VIM MUC1 KRT7 KRT19
13 keratosis, seborrheic 29.5 KRT7 KRT5 CEACAM5
14 squamous cell carcinoma 29.3 STAT3 MUC1 KRT7 KRT19 CEACAM5
15 skin carcinoma 29.3 STAT3 KRT7 KRT5 KRT19 KRT1 CEACAM5
16 skin disease 29.3 VIM S100B KRT5 KRT1
17 sarcoma, synovial 29.0 VIM S100B MUC1 KRT7 KRT19 KRT1
18 basal cell carcinoma 28.9 STAT3 MUC1 KRT7 KRT5 KRT19 KRT1
19 hidradenoma 28.9 VIM MUC1 KRT7 KRT5 CEACAM5
20 syringoma 28.5 VIM S100B MUC1 KRT7 KRT19 CEACAM5
21 rare tumor 10.5
22 bowen's disease 10.5
23 regional odontodysplasia 10.4 VIM KRT19
24 keratosis 10.3
25 liver angiosarcoma 10.3 VIM KRT19
26 hydromyelia 10.3 VIM S100B
27 bednar tumor 10.3 VIM S100B
28 primary hepatic neuroendocrine carcinoma 10.3 VIM S100B
29 mammary paget's disease 10.3
30 angiocentric glioma 10.3 VIM S100B
31 odontogenic myxoma 10.2 VIM S100B
32 papillary tumor of the pineal region 10.2 VIM MUC1
33 endometrial mucinous adenocarcinoma 10.2 VIM MUC1
34 embryonal sarcoma 10.2 VIM S100B
35 sclerosing perineurioma 10.2 S100B MUC1
36 localized hypertrophic neuropathy 10.2 S100B MUC1
37 limbal stem cell deficiency 10.2 MUC1 KRT19
38 reticular perineurioma 10.2 S100B MUC1
39 intracranial cysts 10.2 S100B MUC1
40 paratesticular lipoma 10.2 KRT19 CEACAM5
41 lipoma of spermatic cord 10.2 KRT19 CEACAM5
42 aggressive digital papillary adenocarcinoma 10.2 S100B MUC1
43 meningeal melanocytoma 10.2 S100B MUC1
44 cerebral primitive neuroectodermal tumor 10.2 S100B MUC1
45 reticulum cell sarcoma 10.2 VIM MUC1
46 cholangiolocellular carcinoma 10.2 MUC1 KRT19
47 non-functioning pituitary adenoma 10.2 S100B MUC1
48 colon neuroendocrine neoplasm 10.2 KRT19 CEACAM5
49 liver fibroma 10.2 VIM KRT5
50 filamentary keratitis 10.2 MUC1 KRT1

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to Eccrine Porocarcinoma
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Symptoms & Phenotypes for Eccrine Porocarcinoma

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MGI Mouse Phenotypes related to Eccrine Porocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.17 ATF2 EN1 KRT1 KRT19 KRT5 S100B
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Drugs & Therapeutics for Eccrine Porocarcinoma

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sentinel Lymph Node Biopsy in Porocarcinoma: A Case Reports Completed NCT03647631

Search NIH Clinical Center for Eccrine Porocarcinoma

Cochrane evidence based reviews: eccrine porocarcinoma

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Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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MalaCards organs/tissues related to Eccrine Porocarcinoma:

40
Skin, Lymph Node
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Publications for Eccrine Porocarcinoma

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Articles related to Eccrine Porocarcinoma:

(show top 50) (show all 388)
# Title Authors PMID Year
1
Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures. 54 61
15206695 2004
2
[Eccrine porocarcinoma. A review of 24 cases]. 54 61
8338322 1993
3
Immunotherapy-refractory, EGFR overexpressing metastatic porocarcinoma responding to cetuximab. 61
33588148 2021
4
A case of eccrine porocarcinoma: A treacherous mimic and diagnostic challenge. 61
33433439 2021
5
Malignant Eccrine Porocarcinoma in Finland During 2007 to 2017. 61
33313937 2021
6
Porocarcinoma with areas of mucinous differentiation suggesting multilineage differentiation. 61
32734594 2021
7
A case of YAP1 and NUTM1 rearranged porocarcinoma with corresponding immunohistochemical expression: Review of recent advances in poroma and porocarcinoma pathogenesis with potential diagnostic utility. 61
32757412 2021
8
YAP1-NUTM1 Gene Fusion in Porocarcinoma of the External Auditory Canal. 61
32436169 2020
9
Eccrine Porocarcinoma: A Clinical and Histologic Description of a Series of 11 Cases Treated at the University Hospital Complex in Leon, Spain. 61
33307007 2020
10
Porocarcinoma Located in the Breast: A Case Report. 61
31992443 2020
11
A Case Report of Malignant Eccrine Porocarcinoma Involving the Palm Requiring Surgical Excision and Free Flap Reconstruction. 61
33242313 2020
12
Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer. 61
33109587 2020
13
Utility of YAP1 and NUT immunohistochemistry in the diagnosis of porocarcinoma. 61
33222286 2020
14
Eccrine Porocarcinoma: Avoiding Diagnostic Delay. 61
32924585 2020
15
Engrailed Homeobox 1 and Cytokeratin 19 Are Independent Diagnostic Markers of Eccrine Porocarcinoma and Distinguish It From Squamous Cell Carcinoma. 61
32556098 2020
16
Surgical management and lymph-node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients. 61
32965516 2020
17
Intergluteal Cleft Eccrine Porocarcinoma with Metastasis to Inguinal Region and Lung: Case Report and Review of the Literature. 61
33442371 2020
18
Massive squamous differentiation and anaplastic features in eccrine porocarcinoma as rare and confounding elements. 61
32981049 2020
19
Eccrine porocarcinoma of the head and neck: Meta-analysis of 120 cases. 61
32314845 2020
20
Eccrine porocarcinoma: case report and review of the literature. 61
33050682 2020
21
Demographics and outcomes of eccrine porocarcinoma: results from the National Cancer Database. 61
31954060 2020
22
[Eccrine porocarcinoma of the nose with cervical metastasis：a case report]. 61
32791647 2020
23
Basal Cell Carcinoma and Eccrine Porocarcinoma of the Eyelid. 61
32618820 2020
24
YAP1-MAML2-Rearranged Poroid Squamous Cell Carcinoma (Squamoid Porocarcinoma) Presenting as a Primary Parotid Gland Tumor. 61
32504288 2020
25
Eccrine Porocarcinoma with Squamous Differentiation in a Patient with Oculocutaneous Albinism. 61
32695701 2020
26
Zosteriform Metastases From Eccrine Porocarcinoma. 61
31980129 2020
27
Rapidly Progressive Porocarcinoma of the Ear and Multidisciplinary Approach to Management. 61
32141925 2020
28
State of the art of Mohs surgery for rare cutaneous tumors in the Spanish Registry of Mohs Surgery (REGESMOHS). 61
31777957 2020
29
Eccrine Porocarcinoma: A Rare Tumor of the Eyelid With a Novel Histopathological Finding of Free Tumor Cells in the Tear Film. 61
31868787 2020
30
Porocarcinoma of the nail: A dermoscopic observation. 61
31211409 2020
31
Eccrine Porocarcinoma with Zosteriform Metastasis. 61
32181102 2020
32
Behavior of Cutaneous Adnexal Malignancies: a Single Institution Experience. 61
29948620 2020
33
Porocarcinoma From Preexisting Hidroacanthoma Simplex: Dermoscopic Findings. 61
32363098 2020
34
Eccrine porocarcinoma: A rare case of an in situ tumor with lymph node metastases. 61
31909137 2020
35
A rare case of recurrent eccrine poroma underlying gluteal abscess. 61
32911185 2020
36
Eccrine porocarcinoma in a patient with Schöpf-Schulz-Passarge syndrome. 61
30689236 2019
37
Eccrine Porocarcinoma: A Case Report of a Rare and Aggressive Cutaneous Tumour. 61
31819840 2019
38
A case of eccrine porocarcinoma characterized by a progressive increase in the level of Ki-67 index: case report and review of literature. 61
31601219 2019
39
Zosteriform Lymphangitic Metastases of Eccrine Porocarcinoma. 61
31543539 2019
40
Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab. 61
31492726 2019
41
Altered Rb, p16, and p53 expression is specific for porocarcinoma relative to poroma. 61
31012122 2019
42
Identification of potentially druggable molecular alterations in skin adnexal malignancies. 61
31038235 2019
43
Evaluation of Sentinel Lymph Node Biopsy for Eccrine Porocarcinoma. 61
30868172 2019
44
Eccrine porocarcinoma of the nose: A case report and literature review. 61
30270434 2019
45
Eccrine Porocarcinoma on the Lateral Nose Wall: A Rare Case Report. 61
31427944 2019
46
Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma. 61
31145701 2019
47
The transition between a poroma and a porocarcinoma evidenced by the dermoscopy. 61
33261803 2019
48
The transition between a poroma and a porocarcinoma evidenced by the dermoscopy. 61
31090833 2019
49
The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study. 61
30328107 2019
50
Successful treatment of porocarcinoma with maxacalcitol and imiquimod. 61
30659720 2019
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Variations for Eccrine Porocarcinoma

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Cosmic variations for Eccrine Porocarcinoma:

9 (show top 50) (show all 345)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM106059757 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
2 COSM112354551 TP53 skin,hand,carcinoma,NS c.565G>A p.A189T 17:7674966-7674966 6
3 COSM111759858 TP53 skin,hand,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 6
4 COSM145161899 TP53 skin,hand,carcinoma,NS c.833A>G p.Q278R 17:7673578-7673578 6
5 COSM112254266 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
6 COSM145019215 TP53 skin,hand,carcinoma,NS c.739G>A p.E247K 17:7673764-7673764 6
7 COSM144309924 TP53 skin,hand,carcinoma,NS c.701G>A p.R234H 17:7673802-7673802 6
8 COSM144087977 TP53 skin,hand,carcinoma,NS c.379G>A p.E127K 17:7673764-7673764 6
9 COSM93190386 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
10 COSM106059965 TP53 skin,hand,carcinoma,NS c.647T>A p.V216E 17:7674884-7674884 6
11 COSM105621918 TP53 skin,hand,carcinoma,NS c.782+417G>A p.? 17:7673764-7673764 6
12 COSM143386984 TP53 skin,hand,carcinoma,NS c.193C>T p.Q65* 17:7676059-7676059 6
13 COSM122787283 TP53 skin,hand,carcinoma,NS c.449G>C p.R150P 17:7673775-7673775 6
14 COSM144213765 TP53 skin,hand,carcinoma,NS c.473A>G p.Q158R 17:7673578-7673578 6
15 COSM111765517 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
16 COSM142560894 TP53 skin,hand,carcinoma,NS c.556-1G>A p.? 17:7674291-7674291 6
17 COSM87899076 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
18 COSM145018355 TP53 skin,hand,carcinoma,NS c.556-1G>A p.? 17:7674291-7674291 6
19 COSM143465962 TP53 skin,hand,carcinoma,NS c.448G>A p.A150T 17:7674966-7674966 6
20 COSM144651848 TP53 skin,hand,carcinoma,NS c.556-1G>A p.? 17:7674291-7674291 6
21 COSM105636071 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6
22 COSM144311386 TP53 skin,hand,carcinoma,NS c.739G>A p.E247K 17:7673764-7673764 6
23 COSM106053786 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
24 COSM144757328 TP53 skin,hand,carcinoma,NS c.448G>A p.A150T 17:7674966-7674966 6
25 COSM143945161 TP53 skin,hand,carcinoma,NS c.379G>A p.E127K 17:7673764-7673764 6
26 COSM87899887 TP53 skin,hand,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 6
27 COSM121884502 TP53 skin,hand,carcinoma,NS c.251T>A p.V84E 17:7674884-7674884 6
28 COSM144315643 TP53 skin,hand,carcinoma,NS c.143C>A p.P48Q 17:7676109-7676109 6
29 COSM142566904 TP53 skin,hand,carcinoma,NS c.530T>A p.V177E 17:7674884-7674884 6
30 COSM111807840 TP53 skin,hand,carcinoma,NS c.845G>C p.R282P 17:7673775-7673775 6
31 COSM144652672 TP53 skin,hand,carcinoma,NS c.739G>A p.E247K 17:7673764-7673764 6
32 COSM143000079 TP53 skin,hand,carcinoma,NS c.590T>C p.V197A 17:7674941-7674941 6
33 COSM105621045 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
34 COSM93198616 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6
35 COSM105627660 TP53 skin,hand,carcinoma,NS c.647T>A p.V216E 17:7674884-7674884 6
36 COSM144650760 TP53 skin,hand,carcinoma,NS c.701G>A p.R234H 17:7673802-7673802 6
37 COSM111909038 TP53 skin,hand,carcinoma,NS c.950A>G p.Q317R 17:7673578-7673578 6
38 COSM144087357 TP53 skin,hand,carcinoma,NS c.83-1G>A p.? 17:7674972-7674972 6
39 COSM106067323 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6
40 COSM144014790 TP53 skin,hand,carcinoma,NS c.823G>A p.E275K 17:7673764-7673764 6
41 COSM122278245 TP53 skin,hand,carcinoma,NS c.251T>A p.V84E 17:7674884-7674884 6
42 COSM122740574 TP53 skin,hand,carcinoma,NS c.251T>A p.V84E 17:7674884-7674884 6
43 COSM105627464 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
44 COSM112268626 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6
45 COSM144440622 TP53 skin,hand,carcinoma,NS c.833A>G p.Q278R 17:7673578-7673578 6
46 COSM93190806 TP53 skin,hand,carcinoma,NS c.647T>A p.V216E 17:7674884-7674884 6
47 COSM106140358 TP53 skin,hand,carcinoma,NS c.565G>C p.A189P 17:7674966-7674966 6
48 COSM142838326 TP53 skin,hand,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 6
49 COSM122272113 TP53 skin,hand,carcinoma,NS c.277-1G>A p.? 17:7674291-7674291 6
50 COSM111758217 TP53 skin,hand,carcinoma,NS c.818G>A p.R273H 17:7673802-7673802 6
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Expression for Eccrine Porocarcinoma

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Search GEO for disease gene expression data for Eccrine Porocarcinoma.
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Pathways for Eccrine Porocarcinoma

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Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Keratinization 65
Show member pathways
 12.08 KRT7 KRT5 KRT19 KRT1
2
Cytoskeletal Signaling 4
11.84 VIM MUC1 KRT7 KRT5 KRT19
3
Interleukin-4 and 13 signaling 65
11.6 VIM STAT3 MUC1
4
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.58 VIM STAT3 KRT19 ATF2
5
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.33 VIM S100B EN1
6
Cytoskeleton remodeling Neurofilaments 23
Show member pathways
 11.05 VIM KRT7 KRT5 KRT19 KRT1
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GO Terms for Eccrine Porocarcinoma

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Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.96 VIM STAT3 S100B NUTM1 MUC1 KRT7
2 extracellular exosome GO:0070062 9.7 VIM MUC1 KRT7 KRT5 KRT19 KRT1
3 keratin filament GO:0045095 9.13 KRT7 KRT5 KRT1
4 intermediate filament GO:0005882 9.02 VIM KRT7 KRT5 KRT19 KRT1

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.26 KRT7 KRT5 KRT19 KRT1
2 cornification GO:0070268 8.92 KRT7 KRT5 KRT19 KRT1

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 VIM KRT5 KRT19
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Sources for Eccrine Porocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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