MCID: ECC004
MIFTS: 36

Eccrine Porocarcinoma

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Eccrine Porocarcinoma

MalaCards integrated aliases for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma 12 53 55 44 15 73
Eccrine Porocarcinoma of Skin 12 53
Malignant Eccrine Poroma 12 53
Porocarcinoma 12 53

Classifications:



External Ids:

Disease Ontology 12 DOID:7566
MeSH 44 D057090
NCIt 50 C5560
SNOMED-CT 68 128685001 254708001
UMLS 73 C1266065

Summaries for Eccrine Porocarcinoma

NIH Rare Diseases : 53 Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). They are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. Most people with an eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. Factors that may increase the risk to develop an eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation. Treatment usually involves surgery to remove the tumor.

MalaCards based summary : Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to vulvar eccrine porocarcinoma and hydromyelia. An important gene associated with Eccrine Porocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and colon.

Wikipedia : 76 A malignant acrospiroma (also known as hidradenocarcinoma, and \"Spiradenocarcinoma\") is a sweat gland... more...

Related Diseases for Eccrine Porocarcinoma

Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 vulvar eccrine porocarcinoma 12.3
2 hydromyelia 10.5 S100B VIM
3 bednar tumor 10.5 S100B VIM
4 primary hepatic neuroendocrine carcinoma 10.5 S100B VIM
5 melanotic neuroectodermal tumor 10.5 S100B VIM
6 angiocentric glioma 10.5 S100B VIM
7 juvenile xanthogranuloma 10.5 S100B VIM
8 cutaneous fibrous histiocytoma 10.5 S100B VIM
9 odontogenic myxoma 10.4 S100B VIM
10 granular cell tumor 10.4 S100B VIM
11 embryonal sarcoma 10.4 S100B VIM
12 hidradenocarcinoma 10.4 S100B VIM
13 osteochondroma 10.4 S100B VIM
14 myoepithelioma 10.3 S100B VIM
15 malignant peritoneal mesothelioma 10.3 MUC1 VIM
16 papillary tumor of the pineal region 10.3 MUC1 VIM
17 parachordoma 10.3 MUC1 VIM
18 malignant mixed mullerian tumor 10.3 MUC1 VIM
19 nodular hidradenoma 10.3 MUC1 VIM
20 endometrial mucinous adenocarcinoma 10.3 MUC1 VIM
21 biphasic synovial sarcoma 10.3 MUC1 VIM
22 adenofibroma 10.3 MUC1 VIM
23 neurilemmoma 10.3 S100B VIM
24 hidradenoma 10.3 MUC1 VIM
25 desmoplastic small round cell tumor 10.3 MUC1 VIM
26 perivascular epithelioid cell tumor 10.3 MUC1 VIM
27 reticulum cell sarcoma 10.3 MUC1 VIM
28 sertoli cell tumor 10.3 MUC1 VIM
29 mucinous cystadenocarcinoma 10.3 MUC1 VIM
30 mesenchymal chondrosarcoma 10.3 MUC1 VIM
31 extraskeletal ewing sarcoma 10.3 MUC1 VIM
32 dermoid cyst 10.3 MUC1 VIM
33 localized hypertrophic neuropathy 10.3 MUC1 S100B
34 sclerosing perineurioma 10.2 MUC1 S100B
35 intracranial cysts 10.2 MUC1 S100B
36 reticular perineurioma 10.2 MUC1 S100B
37 fibrous histiocytoma 10.2 S100B VIM
38 chondroid chordoma 10.2 MUC1 VIM
39 filamentary keratitis 10.2 KRT1 MUC1
40 non-functioning pituitary adenoma 10.2 MUC1 S100B
41 epithelioid malignant peripheral nerve sheath tumor 10.2 MUC1 S100B
42 squamous cell carcinoma 10.2
43 bowen's disease 10.2
44 rhabdoid cancer 10.2 MUC1 VIM
45 spindle cell rhabdomyosarcoma 10.2 MUC1 S100B
46 aggressive digital papillary adenocarcinoma 10.2 MUC1 S100B
47 benign mesothelioma 10.2 MUC1 VIM
48 chordoid glioma 10.2 MUC1 S100B
49 papillary adenocarcinoma 10.2 MUC1 VIM
50 secretory meningioma 10.2 MUC1 VIM

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to Eccrine Porocarcinoma

Symptoms & Phenotypes for Eccrine Porocarcinoma

Drugs & Therapeutics for Eccrine Porocarcinoma

Drugs for Eccrine Porocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies Phase 2
3 Immunoglobulins Phase 2
4 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Eccrine Porocarcinoma

Cochrane evidence based reviews: eccrine porocarcinoma

Genetic Tests for Eccrine Porocarcinoma

Anatomical Context for Eccrine Porocarcinoma

MalaCards organs/tissues related to Eccrine Porocarcinoma:

41
Skin, Lymph Node, Colon, Lung

Publications for Eccrine Porocarcinoma

Articles related to Eccrine Porocarcinoma:

(show top 50) (show all 147)
# Title Authors Year
1
Eccrine Porocarcinoma of the Skin is Rising in Incidence in the East of England. ( 29956715 )
2018
2
A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report. ( 29245095 )
2018
3
Eccrine porocarcinoma arising from the knee. ( 29445476 )
2018
4
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature. ( 29894433 )
2018
5
Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma. ( 29872726 )
2018
6
Giant eccrine porocarcinoma in an unusual location. ( 28928336 )
2017
7
Dermoscopic and reflectance confocal microscopic presentation of relapsing eccrine porocarcinoma. ( 28087039 )
2017
8
Subungual Eccrine Porocarcinoma: Rare but Possible. ( 28328706 )
2017
9
Eccrine Porocarcinoma: Patient Characteristics, Clinical and Histopathologic Features, and Treatment in 7 Cases. ( 28110827 )
2017
10
Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature. ( 28831427 )
2017
11
Vulvar eccrine porocarcinoma: report of a case and literature review. ( 29556664 )
2017
12
Cytodiagnosis of Eccrine Porocarcinoma of the Scalp. ( 29118525 )
2017
13
Metastatic Eccrine Porocarcinoma: A Rare Case of Successful Treatment. ( 27721767 )
2016
14
Eccrine Porocarcinoma Presenting as a Hand Cyst. ( 27593487 )
2016
15
Eccrine Porocarcinoma of the Scalp: A Rare Case Report with Review of Literature. ( 26894080 )
2016
16
Eccrine Porocarcinoma presenting as an abdominal wall mass in a patient with ulcerative colitis-A rare case report. ( 27085107 )
2016
17
Eccrine porocarcinoma of the vulva: a case report and review of the literature. ( 27832810 )
2016
18
A Case of Recurrent Eccrine Porocarcinoma with Regional Lymph Nodal Metastasis, Arising on a Bowen's Disease Patch. ( 25972690 )
2015
19
Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review. ( 26205087 )
2015
20
Eccrine porocarcinoma: A wolf in sheep's clothing. ( 25803156 )
2015
21
Eccrine Porocarcinoma Treated by Mohs Micrographic Surgery: Over 6-Year Follow-up of 12 Cases and Literature Review. ( 25984905 )
2015
22
Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work. ( 26333057 )
2015
23
Eccrine porocarcinoma mimicking a venous leg ulcer. ( 26400442 )
2015
24
Eccrine porocarcinoma with extensive cutaneous metastases. ( 26566927 )
2015
25
Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. ( 25515648 )
2015
26
Response to taxane-based chemotherapy in metastatic eccrine porocarcinoma with extensive cutaneous involvement. ( 26837980 )
2015
27
Eccrine Porocarcinoma of Scalp: a Rare Case Report. ( 26516328 )
2015
28
In-transit metastasis of advanced eccrine porocarcinoma. ( 26234455 )
2015
29
Intralesional Photodynamic Therapy for Eccrine Porocarcinoma. ( 26079590 )
2015
30
Metastatic eccrine porocarcinoma successfully treated with carboplatin and epirubicin chemotherapy. ( 26073009 )
2015
31
Eccrine porocarcinoma of the thumb in a patient with chronic exposure to benzene glue. ( 26078532 )
2015
32
Mohs micrographic surgery for eccrine porocarcinoma: an update and review of the literature. ( 25742554 )
2015
33
A Rare Case of Eccrine Porocarcinoma of the Eyelid. ( 24576261 )
2014
34
Zosteriform Metastases of Eccrine Porocarcinoma Mimicking Eruptive Seborrheic Keratoses. ( 24909550 )
2014
35
Eccrine porocarcinoma: a report of 2 cases and review of the literature. ( 24505584 )
2014
36
Rapidly growing eccrine porocarcinoma of the face in a pregnant woman. ( 24621740 )
2014
37
Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. ( 24803063 )
2014
38
Eccrine Porocarcinoma of the Eyelid in a Non-Caucasian Patient. ( 24841732 )
2014
39
Successful Treatment of Eccrine Porocarcinoma Metastasized to a Cervical Lymph Node with CyberKnife Radiosurgery. ( 25076888 )
2014
40
Eccrine porocarcinoma: cytologic diagnosis by fine needle aspiration biopsy (FNAB). ( 24016659 )
2013
41
Eccrine porocarcinoma: clinical and pathological report of eight cases. ( 24403888 )
2013
42
Metastatic eccrine porocarcinoma. ( 24087778 )
2013
43
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. ( 23773127 )
2013
44
Successful management of metastatic eccrine porocarcinoma. ( 24282649 )
2013
45
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. ( 24003279 )
2013
46
FDG PET/CT in Malignant Eccrine Porocarcinoma Arising in a Pre-existing Poroma. ( 23917787 )
2013
47
Eccrine porocarcinoma: a case report. ( 24551693 )
2013
48
Case report of eccrine porocarcinoma in situ associated with eccrine poroma on the forehead. ( 22150617 )
2012
49
Eccrine porocarcinoma with carcinomatous lymphangitis in a patient with history of arsenic exposure: a case report. ( 22108500 )
2012
50
Eccrine porocarcinoma arising within an area of Bowen disease. ( 21973218 )
2012

Variations for Eccrine Porocarcinoma

Cosmic variations for Eccrine Porocarcinoma:

9
(show top 50) (show all 200)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM43751 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 4
2 COSM10726 TP53 skin,hand,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 4
3 COSM10886 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 4
4 COSM43753 TP53 skin,hand,carcinoma,NS c.560-1G>A p.? 17:7674972-7674972 4
5 COSM43544 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 4
6 COSM43537 TP53 skin,hand,carcinoma,NS c.565G>A p.A189T 17:7674966-7674966 4
7 COSM10660 TP53 skin,hand,carcinoma,NS c.818G>A p.R273H 17:7673802-7673802 4
8 COSM44923 TP53 skin,hand,carcinoma,NS c.565G>C p.A189P 17:7674966-7674966 4
9 COSM46278 TP53 skin,hand,carcinoma,NS c.950A>G p.Q317R 17:7673578-7673578 4
10 COSM45145 TP53 skin,hand,carcinoma,NS c.590T>C p.V197A 17:7674941-7674941 4
11 COSM44274 TP53 skin,hand,carcinoma,NS c.647T>A p.V216E 17:7674884-7674884 4
12 COSM44306 TP53 skin,hand,carcinoma,NS c.845G>C p.R282P 17:7673775-7673775 4
13 COSM17596 PTCH1 skin,hand,carcinoma,NS c.863G>A p.G288D 9:95480472-95480472 4
14 COSM17597 PTCH1 skin,hand,carcinoma,NS c.1977G>A p.Q659Q 9:95469024-95469024 4
15 COSM17602 PTCH1 skin,hand,carcinoma,NS c.1922C>T p.P641L 9:95469079-95469079 4
16 COSM6903910 NRAS skin,hand,carcinoma,NS c.395A>G p.E132G 1:114709624-114709624 4
17 COSM6903840 NOTCH2 skin,hand,carcinoma,NS c.2581T>G p.C861G 1:119949025-119949025 4
18 COSM6903903 NOTCH2 skin,hand,carcinoma,NS c.7078C>A p.Q2360K 1:119915644-119915644 4
19 COSM6903895 NOTCH2 skin,hand,carcinoma,NS c.6662T>C p.V2221A 1:119916060-119916060 4
20 COSM6903851 NOTCH2 skin,hand,carcinoma,NS c.3425C>T p.T1142I 1:119937379-119937379 4
21 COSM6903819 NOTCH2 skin,hand,carcinoma,NS c.863C>T p.P288L 1:119986971-119986971 4
22 COSM3472335 NOTCH2 skin,hand,carcinoma,NS c.1340G>A p.G447D 1:119967546-119967546 4
23 COSM4422818 NOTCH2 skin,hand,carcinoma,NS c.5123C>T p.S1708F 1:119922326-119922326 4
24 COSM1667036 NOTCH2 skin,hand,carcinoma,NS c.337C>T p.R113* 1:120005407-120005407 4
25 COSM6903821 NOTCH2 skin,hand,carcinoma,NS c.988T>C p.W330R 1:119969631-119969631 4
26 COSM6903885 NOTCH2 skin,hand,carcinoma,NS c.5782-1G>A p.? 1:119918554-119918554 4
27 COSM6903832 NOTCH2 skin,hand,carcinoma,NS c.1800G>A p.M600I 1:119963689-119963689 4
28 COSM6903902 NOTCH2 skin,hand,carcinoma,NS c.6964C>T p.P2322S 1:119915758-119915758 4
29 COSM6903869 NOTCH2 skin,hand,carcinoma,NS c.4966C>T p.Q1656* 1:119922672-119922672 4
30 COSM6903820 NOTCH2 skin,hand,carcinoma,NS c.872C>T p.T291I 1:119986962-119986962 4
31 COSM6903846 NOTCH2 skin,hand,carcinoma,NS c.3100T>C p.C1034R 1:119940638-119940638 4
32 COSM4891299 NOTCH2 skin,hand,carcinoma,NS c.3293G>A p.C1098Y 1:119937901-119937901 4
33 COSM6903829 NOTCH2 skin,hand,carcinoma,NS c.1640G>A p.C547Y 1:119965494-119965494 4
34 COSM6903657 NOTCH1 skin,hand,carcinoma,NS c.4022A>G p.E1341G 9:136505874-136505874 4
35 COSM6903669 NOTCH1 skin,hand,carcinoma,NS c.4160C>T p.A1387V 9:136505736-136505736 4
36 COSM6903567 NOTCH1 skin,hand,carcinoma,NS c.1433G>A p.C478Y 9:136517760-136517760 4
37 COSM3215961 NOTCH1 skin,hand,carcinoma,NS c.4411G>A p.A1471T 9:136505485-136505485 4
38 COSM6903597 NOTCH1 skin,hand,carcinoma,NS c.2536C>T p.Q846* 9:136511203-136511203 4
39 COSM6903555 NOTCH1 skin,hand,carcinoma,NS c.1280G>A p.G427D 9:136517913-136517913 4
40 COSM6903782 NOTCH1 skin,hand,carcinoma,NS c.6787C>T p.R2263W 9:136496952-136496952 4
41 COSM4493469 NOTCH1 skin,hand,carcinoma,NS c.415C>T p.Q139* 9:136523177-136523177 4
42 COSM99651 NOTCH1 skin,hand,carcinoma,NS c.1093C>T p.R365C 9:136518597-136518597 4
43 COSM6903978 NOTCH1 skin,hand,carcinoma,NS c.4435T>G p.C1479G 9:136505461-136505461 4
44 COSM5575656 NOTCH1 skin,hand,carcinoma,NS c.5057T>C p.V1686A 9:136503292-136503292 4
45 COSM43356 NOTCH1 skin,hand,carcinoma,NS c.6979C>T p.R2327W 9:136496760-136496760 4
46 COSM6903780 NOTCH1 skin,hand,carcinoma,NS c.6757C>A p.P2253T 9:136496982-136496982 4
47 COSM6903571 NOTCH1 skin,hand,carcinoma,NS c.1522A>T p.K508* 9:136517305-136517305 4
48 COSM6903770 NOTCH1 skin,hand,carcinoma,NS c.6160A>T p.K2054* 9:136498919-136498919 4
49 COSM6903625 NOTCH1 skin,hand,carcinoma,NS c.3172-1G>A p.? 9:136508386-136508386 4
50 COSM6903980 NOTCH1 skin,hand,carcinoma,NS c.4435T>C p.C1479R 9:136505461-136505461 4

Expression for Eccrine Porocarcinoma

Search GEO for disease gene expression data for Eccrine Porocarcinoma.

Pathways for Eccrine Porocarcinoma

Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 MUC1 STAT3 VIM
2 10.85 S100B VIM

GO Terms for Eccrine Porocarcinoma

Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT1 KRT15 VIM

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.13 MUC1 STAT3 VIM
2 astrocyte differentiation GO:0048708 8.62 S100B STAT3

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT15 VIM

Sources for Eccrine Porocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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