Eccrine Porocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Eccrine Porocarcinoma

MalaCards integrated aliases for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma ¹¹ ¹⁹ ⁵³ ⁴³ ¹⁴ ¹⁶ ⁷¹

Porocarcinoma ¹¹ ¹⁹ ⁷⁵

Eccrine Porocarcinoma of Skin ¹¹ ¹⁹

Malignant Eccrine Poroma ¹¹ ¹⁹

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:7566

MeSH ⁴³ D057090

NCIt ⁴⁹ C5560

SNOMED-CT ⁶⁸ 254708001

EFO ¹⁶ EFO_1000229

UMLS ⁷¹ C1266065

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Summaries for Eccrine Porocarcinoma

GARD: ¹⁹ Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). They are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. Most people with an Eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. Factors that may increase the risk to develop an Eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation.

MalaCards based summary: Eccrine Porocarcinoma, also known as porocarcinoma, is related to vulvar eccrine porocarcinoma and villous adenoma. An important gene associated with Eccrine Porocarcinoma is KRT19 (Keratin 19), and among its related pathways/superpathways are Nervous system development and Keratinization. The drugs Nivolumab and Talimogene laherparepvec have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and breast, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Wikipedia: ⁷⁵ Porocarcinoma (PCA) (also termed malignant poroma, eccrine porocarcinoma, and malignant eccrine poroma)... more...

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Related Diseases for Eccrine Porocarcinoma

Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 401)

#	Related Disease	Score	Top Affiliating Genes
1	vulvar eccrine porocarcinoma	32.1	PIP MUC1 CEACAM5
2	villous adenoma	30.6	KRT7 CEACAM5
3	lymphangitis	30.5	MUC1 KRT7 CEACAM5
4	skin benign neoplasm	30.5	PIP KRT7 KRT5
5	sarcoma, synovial	30.2	MUC1 KRT7 KRT19
6	basaloid squamous cell carcinoma	30.2	NUTM1 KRT7 KRT5
7	mixed cell type cancer	30.1	KRT7 KRT5 CEACAM5
8	vulva cancer	30.0	PIP KRT7 CEACAM5
9	mammary paget's disease	30.0	PIP MUC1 KRT7 CEACAM5
10	myoepithelial carcinoma	30.0	NUTM1 MAML2 KRT7 KRT5
11	sweat gland benign neoplasm	29.8	PIP NUTM1 MAML2 KRT7 KRT5 CEACAM5
12	sebaceous adenocarcinoma	29.7	PIP KRT7 KRT5
13	basal cell carcinoma	29.7	PIP MUC1 KRT7 KRT5 KRT19 KRT15
14	eccrine adenocarcinoma	29.5	PIP KRT7 KRT5 CEACAM5
15	sweat gland cancer	29.3	PIP MAML2 KRT7 KRT5 KRT19 KRT15
16	paget disease, extramammary	29.2	PIP MUC1 KRT7 KRT5 KRT19 CEACAM5
17	syringoma	29.1	PIP MUC1 KRT7 KRT19 CEACAM5
18	syringocystadenoma papilliferum	28.8	PIP KRT7 KRT5 KRT15 CEACAM5
19	eccrine acrospiroma	28.7	YAP1 WWTR1 PIP NUTM1 MAMLD1 MAML2
20	hidradenoma	28.5	PIP NUTM1 MUC1 MAML2 KRT7 KRT5
21	eccrine sweat gland neoplasm	27.4	YAP1 WWTR1 PIP NUTM1 MAMLD1 MAML2
22	skin carcinoma	10.5
23	rare tumor	10.5
24	basal cell carcinoma 1	10.5
25	bowen's disease	10.5
26	fanconi anemia, complementation group e	10.4
27	keratosis	10.3
28	neurofibroma of the esophagus	10.3	KRT19 CEACAM5
29	schneiderian carcinoma	10.3	NUTM1 MAML2
30	laryngeal neuroendocrine tumor	10.3	NUTM1 KRT19
31	thymus adenocarcinoma	10.3	NUTM1 CEACAM5
32	gallbladder carcinoma in situ	10.3	MUC1 CEACAM5
33	breast hemangiopericytoma	10.3	KRT7 KRT19
34	scrotum paget's disease	10.3	MUC1 KRT7
35	pancreatic serous cystic neoplasm	10.3	KRT7 KRT19
36	cervical clear cell adenocarcinoma	10.3	KRT7 KRT19
37	hereditary lymphedema i	10.3
38	adamantinoma of long bones	10.3	KRT5 KRT19
39	lipid-rich breast carcinoma	10.3	MUC1 KRT5
40	bladder adenocarcinoma	10.3	KRT7 CEACAM5
41	lacrimal gland mucoepidermoid carcinoma	10.3	MAML2 KRT7
42	leukoplakia of penis	10.3	KRT7 CEACAM5
43	lymphoepithelioma-like thymic carcinoma	10.3	NUTM1 KRT5
44	urethral villous adenoma	10.2	KRT7 CEACAM5
45	pancreatic signet ring cell adenocarcinoma	10.2	MUC1 CEACAM5
46	lung adenoid cystic carcinoma	10.2	MAML2 KRT7
47	acute cholangitis	10.2	MUC1 CEACAM5
48	pancreatic serous cystadenocarcinoma	10.2	KRT7 CEACAM5
49	malignant epithelial mesothelioma	10.2	KRT7 CEACAM5
50	vaginal tubulovillous adenoma	10.2	KRT7 CEACAM5

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:

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Symptoms & Phenotypes for Eccrine Porocarcinoma

MGI Mouse Phenotypes related to Eccrine Porocarcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.56	CEACAM5 EN1 KRT19 MUC1 NUTM1 PIP
2	digestive/alimentary	MP:0005381	9.23	CEACAM5 KRT15 KRT19 KRT5 MUC1 PIP

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Drugs & Therapeutics for Eccrine Porocarcinoma

Drugs for Eccrine Porocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Nivolumab

Approved

Phase 2

946414-94-4

2

Talimogene laherparepvec

Approved, Experimental, Investigational

Phase 2

1187560-31-1

3

Immune Checkpoint Inhibitors

Phase 2

4

Antineoplastic Agents, Immunological

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors	Recruiting	NCT02978625	Phase 2
2	Sentinel Lymph Node Biopsy in Porocarcinoma: A Case Reports	Completed	NCT03647631

Search NIH Clinical Center for Eccrine Porocarcinoma

Cochrane evidence based reviews: eccrine porocarcinoma

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Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

Organs/tissues related to Eccrine Porocarcinoma:

MalaCards : Skin, Lymph Node, Breast, Lung, Liver, Bone, Brain

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Publications for Eccrine Porocarcinoma

Articles related to Eccrine Porocarcinoma:

(show top 50) (show all 477)

#	Title	Authors	PMID	Year
1	Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures. ⁵³ ⁶²	Mariko O...Nishioka K	15206695	2004
2	[Eccrine porocarcinoma. A review of 24 cases]. ⁵³ ⁶²	Poiares Baptista A...Figueiredo P	8338322	1993
3	Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases. ⁶²	Goto K...Honma K	36395445	2022
4	Mohs micrographic surgery in rare cutaneous tumors: a retrospective study at a Brazilian tertiary university hospital. ⁶²	Buffo TH...de Moraes AM	36369200	2022
5	Diagnosis and Management of Porocarcinoma. ⁶²	Miyamoto K...Ujiie H	36358649	2022
6	Pedunculated Porocarcinoma Arising from Eccrine Poroma. ⁶²	Kim CH...Park S	36198637	2022
7	Intraabdominal dissemination of porocarcinoma; A case report. ⁶²	Misso K...Chilonga K	36027829	2022
8	Pigmented eccrine poroma in an atypical location. ⁶²	Alfredo MAC...Miot HA	35811192	2022
9	Porocarcinoma: an epidemiological, clinical, and dermoscopic 20-year study. ⁶²	De Giorgi V...Gandini S	35229289	2022
10	Eccrine Porocarcinoma Arising From an Eccrine Poroma: a Case Report. ⁶²	Silveira I...Corsetti Grazziotin T	36159139	2022
11	A systematic review of periungual eccrine neoplasms. ⁶²	Rao EM...Knackstedt TJ	34494261	2022
12	Eccrine Porocarcinoma of the Chest Wall. ⁶²	Kangabam B...Kamei R	35923493	2022
13	YAP1-NUTM1 Gene Fusion in Eccrine Porocarcinoma with Late Metastatic Recurrence: A Case Report. ⁶²	Tormo-Mainar S...Deza G	35818732	2022
14	Whole-exome sequencing in eccrine porocarcinoma indicates promising therapeutic strategies. ⁶²	Denisova E...Redler S	34045664	2022
15	Porocarcinoma: a review. ⁶²	Joshy J...Venables ZC	35149987	2022
16	Dermatoscopic Features of a Metastatic Eccrine Porocarcinoma Arising on Lymphedema. ⁶²	Sgouros D...Katoulis A	35646434	2022
17	Eccrine Porocarcinoma of the Face is a Great Imitator With Aggressive Behavior. ⁶²	Seretis K...Lykoudis EG	35646461	2022
18	Porocarcinoma of the left arm: A report of a rare skin cancer case and literature review. ⁶²	Signorelli C...Ruggeri EM	35441031	2022
19	UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma. ⁶²	Puttonen M...Sihto H	35365704	2022
20	Head and Neck Porocarcinoma: SEER Analysis of Epidemiology and Survival. ⁶²	Scampa M...Oranges CM	35456278	2022
21	The role of postoperative radiotherapy in eccrine porocarcinoma: a multidisciplinary systematic review. ⁶²	Fionda B...Tagliaferri L	35302218	2022
22	Breast metastases of eccrine porocarcinoma. ⁶²	Pinto JF...Chumbo M	35256370	2022
23	Impact of expert pathology review in skin adnexal carcinoma diagnosis: Analysis of 2573 patients from the French CARADERM network. ⁶²	Battistella M...CARADERM network	35090811	2022
24	Recent Advances on Immunohistochemistry and Molecular Biology for the Diagnosis of Adnexal Sweat Gland Tumors. ⁶²	Macagno N...Battistella M	35158743	2022
25	Molecular pathology of skin adnexal tumours. ⁶²	Plotzke JM...Harms PW	34197659	2022
26	Merkel cell polyomavirus is a passenger virus in both poroma and porocarcinoma. ⁶²	Merilainen AS...Koljonen V	34313332	2022
27	Unusual Presentations of Eccrine Porocarcinomas. ⁶²	Juay L...Ho SJE	35111819	2022
28	Primary Eccrine Porocarcinoma of the Breast: A Case Report and Review of Literature. ⁶²	Li YX...Yan Z	35685061	2022
29	High tumour mutational burden and EGFR/MAPK pathway activation are therapeutic targets in metastatic porocarcinoma. ⁶²	Westphal D...Meier F	34185311	2021
30	Primary Eccrine Porocarcinoma of the Thumb With Metastasis: A Rare Case Report and Literature Review. ⁶²	Ma C...Han J	34797810	2021
31	Comparison of Immunohistochemical Expression of Cytokeratin 19, c-KIT, BerEP4, GATA3, and NUTM1 Between Porocarcinoma and Squamous Cell Carcinoma. ⁶²	Goto K...Sugino T	33767067	2021
32	Porocarcinoma of the Eyelid Presenting as an Umbilicated Lesion. ⁶²	Charles NC...Kim ET	33782327	2021
33	Metastatic Porocarcinoma Effectively Managed by Pembrolizumab. ⁶²	Singh A...Vinogradov M	34987895	2021
34	Surgical management and lymph-node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients. ⁶²	Goyal A...Maher I	32965516	2021
35	NUT Is a Specific Immunohistochemical Marker for the Diagnosis of YAP1-NUTM1-rearranged Cutaneous Poroid Neoplasms. ⁶²	Macagno N...Battistella M	33739783	2021
36	Poroid adnexal skin tumors with YAP1 fusions exhibit similar histopathologic features: A series of six YAP1-rearranged adnexal skin tumors. ⁶²	Prieto-Granada C...Stevens TM	33704800	2021
37	Clear Cell Differentiation in Eccrine Porocarcinoma as a High-Risk Feature: Epidemiologic and Pathologic Features of Eccrine Porocarcinoma in a Single-Center Case Series. ⁶²	Koh M...Walker J	33867455	2021
38	A case of metastatic eccrine porocarcinoma without actionable mutations treated with carboplatin and epirubicin chemotherapy. ⁶²	Tahara J...Kabashima K	33729560	2021
39	[Management of malignant adnexal neoplasms of the skin]. ⁶²	Nagel P...Utikal J	34137901	2021
40	Rare case of large eccrine poroma of the eyelid. ⁶²	Kalamkar C...Radke S	34305294	2021
41	Management of brain metastasis from eccrine porocarcinoma: illustrative case. ⁶²	Noda R...Akabane A	35854905	2021
42	Malignant Cutaneous Adnexal Tumors and Role of SLNB. ⁶²	Storino A...Tawa NE	33727135	2021
43	Magnetic Resonance Imaging Characteristics of Poroma and Porocarcinoma. ⁶²	Kawaguchi M...Matsuo M	33797441	2021
44	Clear Cell Porocarcinoma Arising in an Epidermodysplasia Verruciformis Patient. ⁶²	Souza BCE...de Olveira WRP	34446969	2021
45	Massive squamous differentiation and anaplastic features in eccrine porocarcinoma as rare and confounding elements. ⁶²	Pagliuca F...Franco R	32981049	2021
46	Eccrine Porocarcinoma: A Clinical and Histologic Description of a Series of 11 Cases Treated at the University Hospital Complex in Leon, Spain. ⁶²	Olmos Nieva CC...Rodriguez Prieto MA	33307007	2021
47	Eccrine Porocarcinoma: A Challenging Diagnostic and Therapeutic Tumoral Entity. ⁶²	Le HML...D'Hondt L	34177519	2021
48	Immunotherapy-refractory, EGFR overexpressing metastatic porocarcinoma responding to cetuximab. ⁶²	Comito F...Ardizzoni A	33588148	2021
49	Rapidly Progressive Porocarcinoma of the Ear and Multidisciplinary Approach to Management. ⁶²	Rabi S...Hu JC	32141925	2021
50	YAP1-MAML2-Rearranged Poroid Squamous Cell Carcinoma (Squamoid Porocarcinoma) Presenting as a Primary Parotid Gland Tumor. ⁶²	Agaimy A...Cramer T	32504288	2021

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Genes for Eccrine Porocarcinoma

Genes related to Eccrine Porocarcinoma (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	KRT19	Keratin 19	Protein Coding	13.28	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	12.22	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15206695 8338322
3	EN1	Engrailed Homeobox 1	Protein Coding	11.44	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	NUTM1	NUT Midline Carcinoma Family Member 1	Protein Coding	7.3	DISEASES inferred ¹⁴
5	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	7.05	DISEASES inferred ¹⁴
6	FAM118B	Family With Sequence Similarity 118 Member B	Protein Coding	6.72	DISEASES inferred ¹⁴
7	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	6.44	DISEASES inferred ¹⁴
8	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	6.4	DISEASES inferred ¹⁴
9	KRT7	Keratin 7	Protein Coding	6.19	DISEASES inferred ¹⁴
10	KRT5	Keratin 5	Protein Coding	6.16	DISEASES inferred ¹⁴
11	MAMLD1	Mastermind Like Domain Containing 1	Protein Coding	5.96	DISEASES inferred ¹⁴
12	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	5.87	DISEASES inferred ¹⁴
13	CAMTA1	Calmodulin Binding Transcription Activator 1	Protein Coding	5.82	DISEASES inferred ¹⁴
14	PIP	Prolactin Induced Protein	Protein Coding	5.64	DISEASES inferred ¹⁴
15	KRT15	Keratin 15	Protein Coding	5.59	DISEASES inferred ¹⁴

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Variations for Eccrine Porocarcinoma

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Expression for Eccrine Porocarcinoma

Search GEO for disease gene expression data for Eccrine Porocarcinoma.

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Pathways for Eccrine Porocarcinoma

Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Nervous system development ⁶⁶ Show member pathways Axon guidance ⁶⁶ Developmental Biology ⁶⁶	12.58	YAP1 WWTR1 MAMLD1 MAML2 KRT7 KRT5
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	12.1	KRT7 KRT5 KRT19 KRT15
3	Cytoskeletal Signaling ³	11.75	MUC1 KRT7 KRT5 KRT19
4	Gastrulation ⁶⁶ Show member pathways Epithelial-Mesenchymal Transition (EMT) during gastrulation ⁶⁶ Formation of axial mesoderm ⁶⁶ Formation of lateral plate mesoderm ⁶⁶ Formation of paraxial mesoderm ⁶⁶ Germ layer formation at gastrulation ⁶⁶	11.37	YAP1 MAMLD1 MAML2
5	Signaling by Hippo ⁶⁶	10.67	YAP1 WWTR1
6	YAP1- and WWTR1 (TAZ)-stimulated gene expression ⁶⁶	10.5	YAP1 WWTR1

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GO Terms for Eccrine Porocarcinoma

Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	9.23	KRT7 KRT5 KRT19 KRT15

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heart process	GO:0003015	9.46	YAP1 WWTR1
2	regulation of metanephric nephron tubule epithelial cell differentiation	GO:0072307	9.26	YAP1 WWTR1
3	intermediate filament organization	GO:0045109	9.23	KRT7 KRT5 KRT19 KRT15

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Sources for Eccrine Porocarcinoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ECC004 MIFTS: 38	Eccrine Porocarcinoma Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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