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MCID: ECC004
MIFTS: 44

Eccrine Porocarcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Eccrine Porocarcinoma

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MalaCards integrated aliases for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma 12 52 54 43 15 17 71
Eccrine Porocarcinoma of Skin 12 52
Malignant Eccrine Poroma 12 52
Porocarcinoma 12 52

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7566
MeSH 43 D057090
NCIt 49 C5560
UMLS 71 C1266065
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Summaries for Eccrine Porocarcinoma

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NIH Rare Diseases : 52 Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor . They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). They are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. Most people with an eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. Factors that may increase the risk to develop an eccrine porocarcinoma include family history , suppression of the immune system , and exposure to ultraviolet light or radiation. Treatment usually involves surgery to remove the tumor.

MalaCards based summary : Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to vulvar eccrine porocarcinoma and villous adenoma. An important gene associated with Eccrine Porocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. The drugs nivolumab and Talimogene laherparepvec have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and lymph node, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 A malignant acrospiroma is a sweat gland carcinoma of the hand, which may recur locally in 50% of... more...

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Related Diseases for Eccrine Porocarcinoma

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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)
# Related Disease Score Top Affiliating Genes
1 vulvar eccrine porocarcinoma 34.4 MUC1 CEACAM5
2 villous adenoma 30.7 MUC1 CEACAM5
3 skin benign neoplasm 30.5 STAT3 KRT5 KRT1
4 eccrine adenocarcinoma 30.5 KRT7 CEACAM5
5 myoepithelioma 30.4 VIM S100B MUC1
6 eccrine acrospiroma 30.1 KRT7 KRT5 KRT15 CEACAM5
7 sweat gland neoplasm 30.1 KRT7 KRT5 CEACAM5
8 eccrine papillary adenocarcinoma 30.1 KRT7 KRT5 CEACAM5
9 sarcoma, synovial 29.8 VIM S100B MUC1 KRT7
10 spindle cell carcinoma 29.5 VIM MUC1 KRT7 KRT5
11 skin disease 29.4 VIM S100B KRT5 KRT1
12 sweat gland cancer 29.3 KRT7 KRT5 KRT15 CEACAM5
13 hidradenoma 29.1 VIM MUC1 KRT7 KRT5 CEACAM5
14 syringoma 29.0 VIM S100B MUC1 KRT7 CEACAM5
15 basal cell carcinoma 28.6 STAT3 KRT7 KRT5 KRT15 KRT1 CEACAM5
16 rare tumor 10.6
17 bowen's disease 10.6
18 keratosis 10.5
19 skin carcinoma 10.5
20 hydromyelia 10.4 VIM S100B
21 bednar tumor 10.4 VIM S100B
22 primary hepatic neuroendocrine carcinoma 10.4 VIM S100B
23 mammary paget's disease 10.4
24 angiocentric glioma 10.4 VIM S100B
25 papillary tumor of the pineal region 10.4 VIM MUC1
26 odontogenic myxoma 10.4 VIM S100B
27 sclerosing perineurioma 10.4 S100B MUC1
28 localized hypertrophic neuropathy 10.4 S100B MUC1
29 endometrial mucinous adenocarcinoma 10.4 VIM MUC1
30 reticular perineurioma 10.4 S100B MUC1
31 intracranial cysts 10.4 S100B MUC1
32 non-functioning pituitary adenoma 10.3 S100B MUC1
33 aggressive digital papillary adenocarcinoma 10.3 S100B MUC1
34 embryonal sarcoma 10.3 VIM S100B
35 filamentary keratitis 10.3 MUC1 KRT1
36 cerebral primitive neuroectodermal tumor 10.3 S100B MUC1
37 meningeal melanocytoma 10.3 S100B MUC1
38 esophageal adenoid cystic carcinoma 10.3 VIM CEACAM5
39 reticulum cell sarcoma 10.3 VIM MUC1
40 syringocystadenoma papilliferum 10.3 S100B MUC1
41 retinoblastoma 10.3
42 exanthem 10.3
43 squamous cell carcinoma 10.3
44 melanoma 10.3
45 familial retinoblastoma 10.3
46 actinic keratosis 10.3
47 lymphangitis 10.3
48 lymphedema 10.3
49 extraskeletal ewing sarcoma 10.3 VIM MUC1
50 desmoplastic small round cell tumor 10.3 VIM MUC1

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to Eccrine Porocarcinoma
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Symptoms & Phenotypes for Eccrine Porocarcinoma

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GenomeRNAi Phenotypes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.58 RNF13
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.58 VIM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.58 RNF13
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.58 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 9.58 RNF13
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.58 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.58 RNF13
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.58 RNF13
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.58 VIM
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.58 RNF13
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.58 KRT7
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.58 KRT5 KRT7
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.58 KRT7
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.58 KRT5 KRT7 RNF13 VIM
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Drugs & Therapeutics for Eccrine Porocarcinoma

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Drugs for Eccrine Porocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Suspended NCT02978625 Phase 2
2 Sentinel Lymph Node Biopsy in Porocarcinoma: A Case Reports Completed NCT03647631

Search NIH Clinical Center for Eccrine Porocarcinoma

Cochrane evidence based reviews: eccrine porocarcinoma

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Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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MalaCards organs/tissues related to Eccrine Porocarcinoma:

40
Skin, Breast, Lymph Node, Lung, Liver, Ovary, Appendix
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Publications for Eccrine Porocarcinoma

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Articles related to Eccrine Porocarcinoma:

(show top 50) (show all 362)
# Title Authors PMID Year
1
Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures. 54 61
15206695 2004
2
[Eccrine porocarcinoma. A review of 24 cases]. 54 61
8338322 1993
3
State of the art of Mohs surgery for rare cutaneous tumors in the Spanish Registry of Mohs Surgery (REGESMOHS). 61
31777957 2020
4
Zosteriform Metastases From Eccrine Porocarcinoma. 61
31980129 2020
5
Eccrine porocarcinoma: A rare case of an in situ tumor with lymph node metastases. 61
31909137 2020
6
Demographics and Outcomes of Eccrine Porocarcinoma: Results from the National Cancer Database. 61
31954060 2020
7
Porocarcinoma Located in the Breast: A Case Report. 61
31992443 2020
8
Eccrine porocarcinoma in a patient with Schöpf-Schulz-Passarge syndrome. 61
30689236 2019
9
Eccrine Porocarcinoma: A Rare Tumor of the Eyelid With a Novel Histopathological Finding of Free Tumor Cells in the Tear Film. 61
31868787 2019
10
Eccrine Porocarcinoma: A Case Report of a Rare and Aggressive Cutaneous Tumour. 61
31819840 2019
11
A case of eccrine porocarcinoma characterized by a progressive increase in the level of Ki-67 index: case report and review of literature. 61
31601219 2019
12
Zosteriform Lymphangitic Metastases of Eccrine Porocarcinoma. 61
31543539 2019
13
Altered Rb, p16, and p53 expression is specific for porocarcinoma relative to poroma. 61
31012122 2019
14
Metastatic porocarcinoma achieving complete radiological and clinical response with pembrolizumab. 61
31492726 2019
15
Evaluation of Sentinel Lymph Node Biopsy for Eccrine Porocarcinoma. 61
30868172 2019
16
Porocarcinoma of the nail: A dermoscopic observation. 61
31211409 2019
17
Identification of potentially druggable molecular alterations in skin adnexal malignancies. 61
31038235 2019
18
Eccrine porocarcinoma of the nose: A case report and literature review. 61
30270434 2019
19
Eccrine Porocarcinoma on the Lateral Nose Wall: A Rare Case Report. 61
31427944 2019
20
Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma. 61
31145701 2019
21
The transition between a poroma and a porocarcinoma evidenced by the dermoscopy. 61
31090833 2019
22
Eccrine porocarcinoma presenting as a recurrent wart. 61
31039224 2019
23
The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study. 61
30328107 2019
24
Successful treatment of porocarcinoma with maxacalcitol and imiquimod. 61
30659720 2019
25
Malignant Sweat Gland Tumors. 61
30497677 2019
26
Recurrent Metastatic Eccrine Porocarcinoma: A Case Report and Review of the Literature. 61
30739904 2019
27
Eccrine porocarcinoma on the cheek. 61
30739434 2019
28
Monophasic sarcomatoid eccrine porocarcinoma. Report of a case and literature review. 61
31263860 2019
29
[Trichilemmal carcinoma in a patient with squamous cell skin cancer]. 61
30830102 2019
30
Primary eccrine porocarcinoma of the thumb with multiple metastases: a case report and review of the literature. 61
31489340 2019
31
Eccrine Porocarcinoma of the Skin is Rising in Incidence in the East of England. 61
29956715 2018
32
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature. 61
29894433 2018
33
Giant eccrine porocarcinoma in an unusual location. 61
28928336 2018
34
[Clinicopathologic characterization of malignant mixed tumor of the skin accompanied by eccrine porocarcinoma]. 61
29996320 2018
35
Scalp porocarcinoma and lichen planopilaris. 61
30261574 2018
36
Behavior of Cutaneous Adnexal Malignancies: a Single Institution Experience. 61
29948620 2018
37
Dermoscopy of a pigmented apocrine porocarcinoma arising from a pigmented hidroacanthoma simplex. 61
28728215 2018
38
Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas. 61
29269125 2018
39
Complete response of a metastatic porocarcinoma treated with paclitaxel, cetuximab and radiotherapy. 61
29233613 2018
40
Eccrine porocarcinoma arising from the knee. 61
29445476 2018
41
Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma. 61
29872726 2018
42
A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report. 61
29245095 2018
43
Sentinel lymph node biopsy in porocarcinoma: A case reports. 61
30412919 2018
44
A case of massive porocarcinoma. 61
29022792 2017
45
Immunoexpression of Androgen Receptors in Poroid Neoplasms. 61
27153442 2017
46
Adnexal Carcinomas Treated With Mohs Micrographic Surgery: A Comprehensive Review. 61
28445202 2017
47
Cytodiagnosis of Eccrine Porocarcinoma of the Scalp. 61
29118525 2017
48
Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature. 61
28831427 2017
49
Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck. 61
25599317 2017
50
Porocarcinoma; presentation and management, a meta-analysis of 453 cases. 61
28721214 2017
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Variations for Eccrine Porocarcinoma

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Cosmic variations for Eccrine Porocarcinoma:

9 (show top 50) (show all 345)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87899076 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
2 COSM87899887 TP53 skin,hand,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 6
3 COSM87906137 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
4 COSM87915681 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6
5 COSM88075392 TP53 skin,hand,carcinoma,NS c.950A>G p.Q317R 17:7673578-7673578 6
6 COSM87897711 TP53 skin,hand,carcinoma,NS c.818G>A p.R273H 17:7673802-7673802 6
7 COSM87955907 TP53 skin,hand,carcinoma,NS c.845G>C p.R282P 17:7673775-7673775 6
8 COSM87906379 TP53 skin,hand,carcinoma,NS c.647T>A p.V216E 17:7674884-7674884 6
9 COSM87898836 TP53 skin,hand,carcinoma,NS c.560-1G>A p.? 17:7674972-7674972 6
10 COSM88003756 TP53 skin,hand,carcinoma,NS c.565G>C p.A189P 17:7674966-7674966 6
11 COSM88016543 TP53 skin,hand,carcinoma,NS c.565G>A p.A189T 17:7674966-7674966 6
12 COSM88117113 TP53 skin,hand,carcinoma,NS c.590T>C p.V197A 17:7674941-7674941 6
13 COSM90854453 PTCH1 skin,hand,carcinoma,NS c.1922C>T p.P641L 9:95469079-95469079 6
14 COSM90851307 PTCH1 skin,hand,carcinoma,NS c.863G>A p.G288D 9:95480472-95480472 6
15 COSM90852565 PTCH1 skin,hand,carcinoma,NS c.1977G>A p.Q659= 9:95469024-95469024 6
16 COSM97110376 NRAS skin,hand,carcinoma,NS c.395A>G p.E132G 1:114709624-114709624 6
17 COSM88392222 NOTCH2 skin,hand,carcinoma,NS c.6662T>C p.V2221A 1:119916060-119916060 6
18 COSM88392238 NOTCH2 skin,hand,carcinoma,NS c.1340G>A p.G447D 1:119967546-119967546 6
19 COSM88408801 NOTCH2 skin,hand,carcinoma,NS c.1800G>A p.M600I 1:119963689-119963689 6
20 COSM88392232 NOTCH2 skin,hand,carcinoma,NS c.3293G>A p.C1098Y 1:119937901-119937901 6
21 COSM88393300 NOTCH2 skin,hand,carcinoma,NS c.5123C>T p.S1708F 1:119922326-119922326 6
22 COSM88390873 NOTCH2 skin,hand,carcinoma,NS c.863C>T p.P288L 1:119986971-119986971 6
23 COSM88407043 NOTCH2 skin,hand,carcinoma,NS c.3425C>T p.T1142I 1:119937379-119937379 6
24 COSM88409291 NOTCH2 skin,hand,carcinoma,NS c.3100T>C p.C1034R 1:119940638-119940638 6
25 COSM88407049 NOTCH2 skin,hand,carcinoma,NS c.872C>T p.T291I 1:119986962-119986962 6
26 COSM88398931 NOTCH2 skin,hand,carcinoma,NS c.6964C>T p.P2322S 1:119915758-119915758 6
27 COSM88399145 NOTCH2 skin,hand,carcinoma,NS c.2581T>G p.C861G 1:119949025-119949025 6
28 COSM88392225 NOTCH2 skin,hand,carcinoma,NS c.5782-1G>A p.? 1:119918554-119918554 6
29 COSM88388711 NOTCH2 skin,hand,carcinoma,NS c.337C>T p.R113* 1:120005407-120005407 6
30 COSM88408809 NOTCH2 skin,hand,carcinoma,NS c.1640G>A p.C547Y 1:119965494-119965494 6
31 COSM88392244 NOTCH2 skin,hand,carcinoma,NS c.988T>C p.W330R 1:119969631-119969631 6
32 COSM88406295 NOTCH2 skin,hand,carcinoma,NS c.4966C>T p.Q1656* 1:119922672-119922672 6
33 COSM88404616 NOTCH2 skin,hand,carcinoma,NS c.7078C>A p.Q2360K 1:119915644-119915644 6
34 COSM87648187 NOTCH1 skin,hand,carcinoma,NS c.5057T>C p.V1686A 9:136503292-136503292 6
35 COSM87685993 NOTCH1 skin,hand,carcinoma,NS c.4411G>A p.A1471T 9:136505485-136505485 6
36 COSM87695196 NOTCH1 skin,hand,carcinoma,NS c.1631T>C p.L544P 9:136516019-136516019 6
37 COSM87675424 NOTCH1 skin,hand,carcinoma,NS c.6787C>T p.R2263W 9:136496952-136496952 6
38 COSM87695244 NOTCH1 skin,hand,carcinoma,NS c.2536C>T p.Q846* 9:136511203-136511203 6
39 COSM87644755 NOTCH1 skin,hand,carcinoma,NS c.1393G>A p.A465T 9:136517800-136517800 6
40 COSM87692759 NOTCH1 skin,hand,carcinoma,NS c.5042A>G p.D1681G 9:136503307-136503307 6
41 COSM87695180 NOTCH1 skin,hand,carcinoma,NS c.4022A>G p.E1341G 9:136505874-136505874 6
42 COSM87695130 NOTCH1 skin,hand,carcinoma,NS c.4382A>G p.K1461R 9:136505514-136505514 6
43 COSM87642057 NOTCH1 skin,hand,carcinoma,NS c.403+1G>A p.? 9:136523716-136523716 6
44 COSM87676058 NOTCH1 skin,hand,carcinoma,NS c.1172C>T p.P391L 9:136518220-136518220 6
45 COSM87676041 NOTCH1 skin,hand,carcinoma,NS c.1433G>A p.C478Y 9:136517760-136517760 6
46 COSM87655013 NOTCH1 skin,hand,carcinoma,NS c.6979C>T p.R2327W 9:136496760-136496760 6
47 COSM87645862 NOTCH1 skin,hand,carcinoma,NS c.5624A>G p.N1875S 9:136501762-136501762 6
48 COSM87641461 NOTCH1 skin,hand,carcinoma,NS c.1093C>T p.R365C 9:136518597-136518597 6
49 COSM87669475 NOTCH1 skin,hand,carcinoma,NS c.2297G>A p.G766D 9:136513448-136513448 6
50 COSM87645875 NOTCH1 skin,hand,carcinoma,NS c.1523A>G p.K508R 9:136517304-136517304 6
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Expression for Eccrine Porocarcinoma

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Search GEO for disease gene expression data for Eccrine Porocarcinoma.
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Pathways for Eccrine Porocarcinoma

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Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
11.95 VIM MUC1 KRT7 KRT5
2
Keratinization 65
Show member pathways
 11.71 KRT7 KRT5 KRT15 KRT1
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.62 VIM STAT3 ATF2
4
Interleukin-4 and 13 signaling 65
11.49 VIM STAT3 MUC1
5
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 10.96 VIM KRT7 KRT5 KRT1
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GO Terms for Eccrine Porocarcinoma

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Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.96 VIM STAT3 S100B RNF13 MUC1 KRT7
2 extracellular exosome GO:0070062 9.5 VIM MUC1 KRT7 KRT5 KRT15 KRT1
3 keratin filament GO:0045095 9.33 KRT7 KRT5 KRT1
4 intermediate filament GO:0005882 9.02 VIM KRT7 KRT5 KRT15 KRT1

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.26 KRT7 KRT5 KRT15 KRT1
2 astrocyte differentiation GO:0048708 9.16 STAT3 S100B
3 cornification GO:0070268 8.92 KRT7 KRT5 KRT15 KRT1

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 VIM KRT5 KRT15
2 scaffold protein binding GO:0097110 8.8 VIM KRT5 KRT15
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Sources for Eccrine Porocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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