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MCID: ECC004
MIFTS: 37

Eccrine Porocarcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Eccrine Porocarcinoma

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MalaCards integrated aliases for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma 12 54 56 45 15 17 74
Eccrine Porocarcinoma of Skin 12 54
Malignant Eccrine Poroma 12 54
Porocarcinoma 12 54

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7566
MeSH 45 D057090
NCIt 51 C5560
UMLS 74 C1266065
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Summaries for Eccrine Porocarcinoma

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NIH Rare Diseases : 54 Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). They are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. Most people with an eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. Factors that may increase the risk to develop an eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation. Treatment usually involves surgery to remove the tumor.

MalaCards based summary : Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to amelanotic melanoma and vulvar eccrine porocarcinoma. An important gene associated with Eccrine Porocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs nivolumab and Talimogene laherparepvec have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and pituitary.

Wikipedia : 77 A malignant acrospiroma is a sweat gland carcinoma of the hand, which may recur locally in 50% of... more...

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Related Diseases for Eccrine Porocarcinoma

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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 amelanotic melanoma 30.2 S100B VIM
2 vulvar eccrine porocarcinoma 12.5
3 eccrine acrospiroma 10.7
4 bowen's disease 10.4
5 retinoblastoma 10.3
6 keratosis 10.3
7 squamous cell carcinoma 10.3
8 lymphangitis 10.3
9 hydromyelia 10.2 S100B VIM
10 bednar tumor 10.2 S100B VIM
11 primary hepatic neuroendocrine carcinoma 10.2 S100B VIM
12 angiocentric glioma 10.2 S100B VIM
13 juvenile xanthogranuloma 10.2 S100B VIM
14 cutaneous fibrous histiocytoma 10.2 S100B VIM
15 fibrous histiocytoma 10.2 S100B VIM
16 odontogenic myxoma 10.2 S100B VIM
17 malignant peritoneal mesothelioma 10.2 MUC1 VIM
18 granular cell tumor 10.2 S100B VIM
19 breast cancer 10.2
20 rothmund-thomson syndrome 10.2
21 papillary tumor of the pineal region 10.1 MUC1 VIM
22 nevus, epidermal 10.1
23 keratosis, seborrheic 10.1
24 schopf-schulz-passarge syndrome 10.1
25 cervical cancer 10.1
26 lymphedema 10.1
27 ulcerative colitis 10.1
28 colitis 10.1
29 melanoma 10.1
30 mammary paget's disease 10.1
31 basaloid squamous cell carcinoma 10.1
32 parachordoma 10.1 MUC1 VIM
33 secretory meningioma 10.1 MUC1 VIM
34 nodular hidradenoma 10.1 MUC1 VIM
35 hidradenoma 10.1 MUC1 VIM
36 clear cell ependymoma 10.1 MUC1 VIM
37 embryonal sarcoma 10.1 S100B VIM
38 endometrial mucinous adenocarcinoma 10.1 MUC1 VIM
39 biphasic synovial sarcoma 10.1 MUC1 VIM
40 hidradenocarcinoma 10.1 S100B VIM
41 papillary adenocarcinoma 10.1 MUC1 VIM
42 adenofibroma 10.1 MUC1 VIM
43 clear cell meningioma 10.1 MUC1 VIM
44 osteochondroma 10.1 S100B VIM
45 desmoplastic small round cell tumor 10.1 MUC1 VIM
46 perivascular epithelioid cell tumor 10.1 MUC1 VIM
47 reticulum cell sarcoma 10.1 MUC1 VIM
48 sertoli cell tumor 10.1 MUC1 VIM
49 mesenchymal chondrosarcoma 10.1 MUC1 VIM
50 extraskeletal ewing sarcoma 10.1 MUC1 VIM

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to Eccrine Porocarcinoma
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Symptoms & Phenotypes for Eccrine Porocarcinoma

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Drugs & Therapeutics for Eccrine Porocarcinoma

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Drugs for Eccrine Porocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
2 Sentinel Lymph Node Biopsy in Porocarcinoma Completed NCT03647631

Search NIH Clinical Center for Eccrine Porocarcinoma

Cochrane evidence based reviews: eccrine porocarcinoma

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Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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MalaCards organs/tissues related to Eccrine Porocarcinoma:

42
Skin, Lymph Node, Pituitary, Lung, Colon, Breast, Pineal
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Publications for Eccrine Porocarcinoma

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Articles related to Eccrine Porocarcinoma:

(show top 50) (show all 153)
# Title Authors Year
1
Eccrine porocarcinoma of the nose: A case report and literature review. ( 30270434 )
2019
2
Eccrine porocarcinoma in a patient with Schöpf-Schulz-Passarge syndrome. ( 30689236 )
2019
3
Eccrine porocarcinoma on the cheek. ( 30739434 )
2019
4
Recurrent Metastatic Eccrine Porocarcinoma: A Case Report and Review of the Literature. ( 30739904 )
2019
5
Evaluation of Sentinel Lymph Node Biopsy for Eccrine Porocarcinoma. ( 30868172 )
2019
6
Eccrine porocarcinoma presenting as a recurrent wart. ( 31039224 )
2019
7
Giant eccrine porocarcinoma in an unusual location. ( 28928336 )
2018
8
A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report. ( 29245095 )
2018
9
Eccrine porocarcinoma arising from the knee. ( 29445476 )
2018
10
Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma. ( 29872726 )
2018
11
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature. ( 29894433 )
2018
12
Eccrine Porocarcinoma of the Skin is Rising in Incidence in the East of England. ( 29956715 )
2018
13
Dermoscopic and reflectance confocal microscopic presentation of relapsing eccrine porocarcinoma. ( 28087039 )
2017
14
Eccrine Porocarcinoma: Patient Characteristics, Clinical and Histopathologic Features, and Treatment in 7 Cases. ( 28110827 )
2017
15
Subungual Eccrine Porocarcinoma: Rare but Possible. ( 28328706 )
2017
16
Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature. ( 28831427 )
2017
17
Cytodiagnosis of Eccrine Porocarcinoma of the Scalp. ( 29118525 )
2017
18
Vulvar eccrine porocarcinoma: report of a case and literature review. ( 29556664 )
2017
19
Eccrine porocarcinoma shares dermoscopic characteristics with eccrine poroma: A report of three cases and review of the published work. ( 26333057 )
2016
20
Eccrine porocarcinoma mimicking a venous leg ulcer. ( 26400442 )
2016
21
Eccrine porocarcinoma with extensive cutaneous metastases. ( 26566927 )
2016
22
Eccrine Porocarcinoma of the Scalp: A Rare Case Report with Review of Literature. ( 26894080 )
2016
23
Eccrine Porocarcinoma presenting as an abdominal wall mass in a patient with ulcerative colitis-A rare case report. ( 27085107 )
2016
24
Eccrine Porocarcinoma Presenting as a Hand Cyst. ( 27593487 )
2016
25
Metastatic Eccrine Porocarcinoma: A Rare Case of Successful Treatment. ( 27721767 )
2016
26
Eccrine porocarcinoma of the vulva: a case report and review of the literature. ( 27832810 )
2016
27
A Case of Recurrent Eccrine Porocarcinoma with Regional Lymph Nodal Metastasis, Arising on a Bowen's Disease Patch. ( 25972690 )
2015
28
A Rare Case of Eccrine Porocarcinoma of the Eyelid. ( 24576261 )
2015
29
Eccrine Porocarcinoma of the Eyelid in a Non-Caucasian Patient. ( 24841732 )
2015
30
Zosteriform metastases of eccrine porocarcinoma mimicking eruptive seborrhoeic keratoses. ( 24909550 )
2015
31
Eccrine porocarcinoma: epidemiologic and histopathologic characteristics. ( 25515648 )
2015
32
Mohs micrographic surgery for eccrine porocarcinoma: an update and review of the literature. ( 25742554 )
2015
33
Eccrine Porocarcinoma: A Wolf in Sheep's Clothing. ( 25803156 )
2015
34
Eccrine Porocarcinoma Treated by Mohs Micrographic Surgery: Over 6-Year Follow-up of 12 Cases and Literature Review. ( 25984905 )
2015
35
Metastatic eccrine porocarcinoma successfully treated with carboplatin and epirubicin chemotherapy. ( 26073009 )
2015
36
Eccrine porocarcinoma of the thumb in a patient with chronic exposure to benzene glue. ( 26078532 )
2015
37
Intralesional Photodynamic Therapy for Eccrine Porocarcinoma. ( 26079590 )
2015
38
Treatment of eccrine porocarcinoma with Mohs micrographic surgery: a cases series and literature review. ( 26205087 )
2015
39
In-transit metastasis of advanced eccrine porocarcinoma. ( 26234455 )
2015
40
Eccrine Porocarcinoma of Scalp: a Rare Case Report. ( 26516328 )
2015
41
Response to taxane-based chemotherapy in metastatic eccrine porocarcinoma with extensive cutaneous involvement. ( 26837980 )
2015
42
Eccrine porocarcinoma: a report of 2 cases and review of the literature. ( 24505584 )
2014
43
Rapidly growing eccrine porocarcinoma of the face in a pregnant woman. ( 24621740 )
2014
44
Eccrine poroma and eccrine porocarcinoma in linear epidermal nevus. ( 24803063 )
2014
45
Successful Treatment of Eccrine Porocarcinoma Metastasized to a Cervical Lymph Node with CyberKnife Radiosurgery. ( 25076888 )
2014
46
FDG PET/CT in malignant eccrine porocarcinoma arising in a pre-existing poroma. ( 23917787 )
2014
47
Eccrine porocarcinoma: a case report. ( 24551693 )
2013
48
Treatment of multiple bilateral primary eccrine porocarcinoma with topical diphencyprone: a case report. ( 23773127 )
2013
49
A case of eccrine porocarcinoma: usefulness of immunostain for s-100 protein in the diagnoses of recurrent and metastatic dedifferentiated lesions. ( 24003279 )
2013
50
Eccrine porocarcinoma: cytologic diagnosis by fine needle aspiration biopsy (FNAB). ( 24016659 )
2013
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Variations for Eccrine Porocarcinoma

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Cosmic variations for Eccrine Porocarcinoma:

9 (show top 50) (show all 200)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10660 TP53 skin,hand,carcinoma,NS c.818G>A p.R273H 17:7673802-7673802 0
2 COSM43751 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 0
3 COSM10726 TP53 skin,hand,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 0
4 COSM10886 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 0
5 COSM43753 TP53 skin,hand,carcinoma,NS c.560-1G>A p.? 17:7674972-7674972 0
6 COSM43544 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 0
7 COSM43537 TP53 skin,hand,carcinoma,NS c.565G>A p.A189T 17:7674966-7674966 0
8 COSM44923 TP53 skin,hand,carcinoma,NS c.565G>C p.A189P 17:7674966-7674966 0
9 COSM46278 TP53 skin,hand,carcinoma,NS c.950A>G p.Q317R 17:7673578-7673578 0
10 COSM45145 TP53 skin,hand,carcinoma,NS c.590T>C p.V197A 17:7674941-7674941 0
11 COSM44274 TP53 skin,hand,carcinoma,NS c.647T>A p.V216E 17:7674884-7674884 0
12 COSM44306 TP53 skin,hand,carcinoma,NS c.845G>C p.R282P 17:7673775-7673775 0
13 COSM17596 PTCH1 skin,hand,carcinoma,NS c.863G>A p.G288D 9:95480472-95480472 0
14 COSM17597 PTCH1 skin,hand,carcinoma,NS c.1977G>A p.Q659Q 9:95469024-95469024 0
15 COSM17602 PTCH1 skin,hand,carcinoma,NS c.1922C>T p.P641L 9:95469079-95469079 0
16 COSM6903910 NRAS skin,hand,carcinoma,NS c.395A>G p.E132G 1:114709624-114709624 0
17 COSM6903903 NOTCH2 skin,hand,carcinoma,NS c.7078C>A p.Q2360K 1:119915644-119915644 0
18 COSM6903895 NOTCH2 skin,hand,carcinoma,NS c.6662T>C p.V2221A 1:119916060-119916060 0
19 COSM6903851 NOTCH2 skin,hand,carcinoma,NS c.3425C>T p.T1142I 1:119937379-119937379 0
20 COSM6903819 NOTCH2 skin,hand,carcinoma,NS c.863C>T p.P288L 1:119986971-119986971 0
21 COSM3472335 NOTCH2 skin,hand,carcinoma,NS c.1340G>A p.G447D 1:119967546-119967546 0
22 COSM4422818 NOTCH2 skin,hand,carcinoma,NS c.5123C>T p.S1708F 1:119922326-119922326 0
23 COSM1667036 NOTCH2 skin,hand,carcinoma,NS c.337C>T p.R113* 1:120005407-120005407 0
24 COSM6903821 NOTCH2 skin,hand,carcinoma,NS c.988T>C p.W330R 1:119969631-119969631 0
25 COSM6903885 NOTCH2 skin,hand,carcinoma,NS c.5782-1G>A p.? 1:119918554-119918554 0
26 COSM6903832 NOTCH2 skin,hand,carcinoma,NS c.1800G>A p.M600I 1:119963689-119963689 0
27 COSM6903902 NOTCH2 skin,hand,carcinoma,NS c.6964C>T p.P2322S 1:119915758-119915758 0
28 COSM6903840 NOTCH2 skin,hand,carcinoma,NS c.2581T>G p.C861G 1:119949025-119949025 0
29 COSM6903820 NOTCH2 skin,hand,carcinoma,NS c.872C>T p.T291I 1:119986962-119986962 0
30 COSM6903869 NOTCH2 skin,hand,carcinoma,NS c.4966C>T p.Q1656* 1:119922672-119922672 0
31 COSM6903846 NOTCH2 skin,hand,carcinoma,NS c.3100T>C p.C1034R 1:119940638-119940638 0
32 COSM4891299 NOTCH2 skin,hand,carcinoma,NS c.3293G>A p.C1098Y 1:119937901-119937901 0
33 COSM6903829 NOTCH2 skin,hand,carcinoma,NS c.1640G>A p.C547Y 1:119965494-119965494 0
34 COSM6903657 NOTCH1 skin,hand,carcinoma,NS c.4022A>G p.E1341G 9:136505874-136505874 0
35 COSM6903567 NOTCH1 skin,hand,carcinoma,NS c.1433G>A p.C478Y 9:136517760-136517760 0
36 COSM6903669 NOTCH1 skin,hand,carcinoma,NS c.4160C>T p.A1387V 9:136505736-136505736 0
37 COSM3215961 NOTCH1 skin,hand,carcinoma,NS c.4411G>A p.A1471T 9:136505485-136505485 0
38 COSM6903597 NOTCH1 skin,hand,carcinoma,NS c.2536C>T p.Q846* 9:136511203-136511203 0
39 COSM6903555 NOTCH1 skin,hand,carcinoma,NS c.1280G>A p.G427D 9:136517913-136517913 0
40 COSM6903782 NOTCH1 skin,hand,carcinoma,NS c.6787C>T p.R2263W 9:136496952-136496952 0
41 COSM4493469 NOTCH1 skin,hand,carcinoma,NS c.415C>T p.Q139* 9:136523177-136523177 0
42 COSM99651 NOTCH1 skin,hand,carcinoma,NS c.1093C>T p.R365C 9:136518597-136518597 0
43 COSM6903978 NOTCH1 skin,hand,carcinoma,NS c.4435T>G p.C1479G 9:136505461-136505461 0
44 COSM5575656 NOTCH1 skin,hand,carcinoma,NS c.5057T>C p.V1686A 9:136503292-136503292 0
45 COSM120968 NOTCH1 skin,hand,carcinoma,NS c.1270G>A p.E424K 9:136517923-136517923 0
46 COSM43356 NOTCH1 skin,hand,carcinoma,NS c.6979C>T p.R2327W 9:136496760-136496760 0
47 COSM6903571 NOTCH1 skin,hand,carcinoma,NS c.1522A>T p.K508* 9:136517305-136517305 0
48 COSM6903770 NOTCH1 skin,hand,carcinoma,NS c.6160A>T p.K2054* 9:136498919-136498919 0
49 COSM6903625 NOTCH1 skin,hand,carcinoma,NS c.3172-1G>A p.? 9:136508386-136508386 0
50 COSM6903980 NOTCH1 skin,hand,carcinoma,NS c.4435T>C p.C1479R 9:136505461-136505461 0
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Expression for Eccrine Porocarcinoma

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Search GEO for disease gene expression data for Eccrine Porocarcinoma.
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Pathways for Eccrine Porocarcinoma

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Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Interleukin-4 and 13 signaling 67
10.86 MUC1 STAT3 VIM
2
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
10.85 S100B VIM
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GO Terms for Eccrine Porocarcinoma

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Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT1 KRT15 VIM

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.13 MUC1 STAT3 VIM
2 astrocyte differentiation GO:0048708 8.62 S100B STAT3

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT15 VIM
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Sources for Eccrine Porocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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