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MCID: ECC004
MIFTS: 43

Eccrine Porocarcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Eccrine Porocarcinoma

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MalaCards integrated aliases for Eccrine Porocarcinoma:

Name: Eccrine Porocarcinoma 12 53 55 44 15 17 72
Eccrine Porocarcinoma of Skin 12 53
Malignant Eccrine Poroma 12 53
Porocarcinoma 12 53

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7566
MeSH 44 D057090
NCIt 50 C5560
UMLS 72 C1266065
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Summaries for Eccrine Porocarcinoma

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NIH Rare Diseases : 53 Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. They affect the eccrine sweat glands, which are the major sweat glands of the body. Eccrine porocarcinoma usually are found in adults older than 60 and appear as a single red elevated solid mass (nodule) or a thickened or elevated lesion (plaque). They are found anywhere on the body, but occur most commonly on the lower limbs, head, and upper limbs. Most people with an eccrine porocarcinoma do not have symptoms; however some individuals may notice bleeding from the tumor or itching. Factors that may increase the risk to develop an eccrine porocarcinoma include family history, suppression of the immune system, and exposure to ultraviolet light or radiation. Treatment usually involves surgery to remove the tumor.

MalaCards based summary : Eccrine Porocarcinoma, also known as eccrine porocarcinoma of skin, is related to amelanotic melanoma and hidradenoma. An important gene associated with Eccrine Porocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. The drugs Talimogene laherparepvec and nivolumab have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells.

Wikipedia : 75 A malignant acrospiroma is a sweat gland carcinoma of the hand, which may recur locally in 50% of... more...

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Related Diseases for Eccrine Porocarcinoma

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Diseases related to Eccrine Porocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 amelanotic melanoma 30.9 VIM S100B
2 hidradenoma 30.8 VIM MUC1
3 myoepithelioma 30.8 VIM S100B
4 skin benign neoplasm 30.5 KRT5 KRT1
5 hidradenocarcinoma 30.1 VIM S100B KRT5
6 sweat gland cancer 30.0 KRT5 KRT15
7 sarcoma, synovial 30.0 VIM MUC1
8 syringoma 30.0 VIM S100B MUC1
9 spindle cell carcinoma 29.7 VIM MUC1 KRT5
10 vulvar eccrine porocarcinoma 12.7
11 eccrine acrospiroma 11.0
12 rare tumor 10.6
13 bowen's disease 10.6
14 hydromyelia 10.5 VIM S100B
15 bednar tumor 10.5 VIM S100B
16 primary hepatic neuroendocrine carcinoma 10.5 VIM S100B
17 angiocentric glioma 10.5 VIM S100B
18 juvenile xanthogranuloma 10.5 VIM S100B
19 keratosis 10.5
20 basal cell carcinoma 10.5
21 skin carcinoma 10.5
22 cutaneous fibrous histiocytoma 10.4 VIM S100B
23 fibrous histiocytoma 10.4 VIM S100B
24 odontogenic myxoma 10.4 VIM S100B
25 granular cell tumor 10.4 VIM S100B
26 mammary paget's disease 10.4
27 embryonal sarcoma 10.4 VIM S100B
28 malignant peritoneal mesothelioma 10.4 VIM MUC1
29 papillary tumor of the pineal region 10.4 VIM MUC1
30 secretory meningioma 10.4 VIM MUC1
31 parachordoma 10.4 VIM MUC1
32 clear cell ependymoma 10.4 VIM MUC1
33 nodular hidradenoma 10.4 VIM MUC1
34 osteochondroma 10.4 VIM S100B
35 papillary adenocarcinoma 10.4 VIM MUC1
36 biphasic synovial sarcoma 10.4 VIM MUC1
37 endometrial mucinous adenocarcinoma 10.4 VIM MUC1
38 clear cell meningioma 10.4 VIM MUC1
39 adenofibroma 10.4 VIM MUC1
40 desmoplastic small round cell tumor 10.3 VIM MUC1
41 perivascular epithelioid cell tumor 10.3 VIM MUC1
42 sclerosing perineurioma 10.3 S100B MUC1
43 localized hypertrophic neuropathy 10.3 S100B MUC1
44 reticulum cell sarcoma 10.3 VIM MUC1
45 reticular perineurioma 10.3 S100B MUC1
46 extraskeletal ewing sarcoma 10.3 VIM MUC1
47 intracranial cysts 10.3 S100B MUC1
48 mesenchymal chondrosarcoma 10.3 VIM MUC1
49 sertoli cell tumor 10.3 VIM MUC1
50 non-functioning pituitary adenoma 10.3 S100B MUC1

Graphical network of the top 20 diseases related to Eccrine Porocarcinoma:



Diseases related to Eccrine Porocarcinoma
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Symptoms & Phenotypes for Eccrine Porocarcinoma

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Drugs & Therapeutics for Eccrine Porocarcinoma

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Drugs for Eccrine Porocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
2
nivolumab Approved Phase 2 946414-94-4
3 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Talimogene Laherparepvec Followed by Talimogene Laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carcinoma, Merkel Cell Carcinoma, and Other Rare Skin Tumors Suspended NCT02978625 Phase 2
2 Sentinel Lymph Node Biopsy in Porocarcinoma: A Case Reports Completed NCT03647631

Search NIH Clinical Center for Eccrine Porocarcinoma

Cochrane evidence based reviews: eccrine porocarcinoma

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Genetic Tests for Eccrine Porocarcinoma

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Anatomical Context for Eccrine Porocarcinoma

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MalaCards organs/tissues related to Eccrine Porocarcinoma:

41
Skin, Lymph Node, T Cells, Nk Cells, Lung, Colon, Bone
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Publications for Eccrine Porocarcinoma

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Articles related to Eccrine Porocarcinoma:

(show top 50) (show all 351)
# Title Authors PMID Year
1
Eccrine porocarcinoma with Bowenoid changes: epithelial membrane antigen is not a useful marker for malignant tumours arising from eccrine gland structures. 9 38
15206695 2004
2
[Eccrine porocarcinoma. A review of 24 cases]. 9 38
8338322 1993
3
Altered Rb, p16, and p53 expression is specific for porocarcinoma relative to poroma. 38
31012122 2019
4
Evaluation of Sentinel Lymph Node Biopsy for Eccrine Porocarcinoma. 38
30868172 2019
5
Porocarcinoma of the nail: A dermoscopic observation. 38
31211409 2019
6
Identification of potentially druggable molecular alterations in skin adnexal malignancies. 38
31038235 2019
7
Eccrine Porocarcinoma on the Lateral Nose Wall: A Rare Case Report. 38
31427944 2019
8
Eccrine porocarcinoma of the nose: A case report and literature review. 38
30270434 2019
9
Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma. 38
31145701 2019
10
The transition between a poroma and a porocarcinoma evidenced by the dermoscopy. 38
31090833 2019
11
The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study. 38
30328107 2019
12
Eccrine porocarcinoma presenting as a recurrent wart. 38
31039224 2019
13
Successful treatment of porocarcinoma with maxacalcitol and imiquimod. 38
30659720 2019
14
Eccrine porocarcinoma on the cheek. 38
30739434 2019
15
Recurrent Metastatic Eccrine Porocarcinoma: A Case Report and Review of the Literature. 38
30739904 2019
16
Malignant Sweat Gland Tumors. 38
30497677 2019
17
Monophasic sarcomatoid eccrine porocarcinoma. Report of a case and literature review. 38
31263860 2019
18
[Trichilemmal carcinoma in a patient with squamous cell skin cancer]. 38
30830102 2019
19
Eccrine porocarcinoma in a patient with Schöpf-Schulz-Passarge syndrome. 38
30689236 2019
20
Eccrine Porocarcinoma of the Skin is Rising in Incidence in the East of England. 38
29956715 2018
21
Eccrine Porocarcinoma: New Insights and a Systematic Review of the Literature. 38
29894433 2018
22
Giant eccrine porocarcinoma in an unusual location. 38
28928336 2018
23
[Clinicopathologic characterization of malignant mixed tumor of the skin accompanied by eccrine porocarcinoma]. 38
29996320 2018
24
Scalp porocarcinoma and lichen planopilaris. 38
30261574 2018
25
Behavior of Cutaneous Adnexal Malignancies: a Single Institution Experience. 38
29948620 2018
26
Dermoscopy of a pigmented apocrine porocarcinoma arising from a pigmented hidroacanthoma simplex. 38
28728215 2018
27
Targeted molecular profiling reveals genetic heterogeneity of poromas and porocarcinomas. 38
29269125 2018
28
Complete response of a metastatic porocarcinoma treated with paclitaxel, cetuximab and radiotherapy. 38
29233613 2018
29
Eccrine porocarcinoma arising from the knee. 38
29445476 2018
30
Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma. 38
29872726 2018
31
A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report. 38
29245095 2018
32
Sentinel lymph node biopsy in porocarcinoma: A case reports. 38
30412919 2018
33
A case of massive porocarcinoma. 38
29022792 2017
34
Immunoexpression of Androgen Receptors in Poroid Neoplasms. 38
27153442 2017
35
Adnexal Carcinomas Treated With Mohs Micrographic Surgery: A Comprehensive Review. 38
28445202 2017
36
Cytodiagnosis of Eccrine Porocarcinoma of the Scalp. 38
29118525 2017
37
Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature. 38
28831427 2017
38
Porocarcinoma; presentation and management, a meta-analysis of 453 cases. 38
28721214 2017
39
Surgery and Adjuvant Radiation for High-risk Skin Adnexal Carcinoma of the Head and Neck. 38
25599317 2017
40
Porocarcinoma with hidroacanthoma simplex-like features in association with seborrheic keratosis. 38
28468734 2017
41
Concomitant poroma and porocarcinoma. 38
28954110 2017
42
Subungual Eccrine Porocarcinoma: Rare but Possible. 38
28328706 2017
43
Porocarcinoma: a rare cutaneous lesion. 38
28768383 2017
44
CD117 immunohistochemistry in sarcomatoid porocarcinoma. 38
28436041 2017
45
Dermoscopic Findings in Porocarcinoma. 38
28005624 2017
46
Eccrine Porocarcinoma: Patient Characteristics, Clinical and Histopathologic Features, and Treatment in 7 Cases. 38
28110827 2017
47
Eccrine Poroma of the Postauricular Area. 38
28913302 2017
48
Dermoscopic and reflectance confocal microscopic presentation of relapsing eccrine porocarcinoma. 38
28087039 2017
49
Long-term survival after multidisciplinary management of a metastatic sarcomatoid porocarcinoma with repeated exeresis, radiotherapy, chemotherapy and cetuximab: case report and review of literature. 38
25236317 2017
50
Vulvar eccrine porocarcinoma: report of a case and literature review. 38
29556664 2017
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Variations for Eccrine Porocarcinoma

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Cosmic variations for Eccrine Porocarcinoma:

9 (show top 50) (show all 200)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10660 TP53 skin,hand,carcinoma,NS c.818G>A p.R273H 17:7673802-7673802 6
2 COSM43751 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
3 COSM10726 TP53 skin,hand,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 6
4 COSM10886 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6
5 COSM43753 TP53 skin,hand,carcinoma,NS c.560-1G>A p.? 17:7674972-7674972 6
6 COSM43544 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
7 COSM43537 TP53 skin,hand,carcinoma,NS c.565G>A p.A189T 17:7674966-7674966 6
8 COSM44923 TP53 skin,hand,carcinoma,NS c.565G>C p.A189P 17:7674966-7674966 6
9 COSM46278 TP53 skin,hand,carcinoma,NS c.950A>G p.Q317R 17:7673578-7673578 6
10 COSM45145 TP53 skin,hand,carcinoma,NS c.590T>C p.V197A 17:7674941-7674941 6
11 COSM44274 TP53 skin,hand,carcinoma,NS c.647T>A p.V216E 17:7674884-7674884 6
12 COSM44306 TP53 skin,hand,carcinoma,NS c.845G>C p.R282P 17:7673775-7673775 6
13 COSM17596 PTCH1 skin,hand,carcinoma,NS c.863G>A p.G288D 9:95480472-95480472 6
14 COSM17597 PTCH1 skin,hand,carcinoma,NS c.1977G>A p.Q659Q 9:95469024-95469024 6
15 COSM17602 PTCH1 skin,hand,carcinoma,NS c.1922C>T p.P641L 9:95469079-95469079 6
16 COSM6903910 NRAS skin,hand,carcinoma,NS c.395A>G p.E132G 1:114709624-114709624 6
17 COSM6903903 NOTCH2 skin,hand,carcinoma,NS c.7078C>A p.Q2360K 1:119915644-119915644 6
18 COSM6903895 NOTCH2 skin,hand,carcinoma,NS c.6662T>C p.V2221A 1:119916060-119916060 6
19 COSM6903851 NOTCH2 skin,hand,carcinoma,NS c.3425C>T p.T1142I 1:119937379-119937379 6
20 COSM6903819 NOTCH2 skin,hand,carcinoma,NS c.863C>T p.P288L 1:119986971-119986971 6
21 COSM3472335 NOTCH2 skin,hand,carcinoma,NS c.1340G>A p.G447D 1:119967546-119967546 6
22 COSM4422818 NOTCH2 skin,hand,carcinoma,NS c.5123C>T p.S1708F 1:119922326-119922326 6
23 COSM1667036 NOTCH2 skin,hand,carcinoma,NS c.337C>T p.R113* 1:120005407-120005407 6
24 COSM6903821 NOTCH2 skin,hand,carcinoma,NS c.988T>C p.W330R 1:119969631-119969631 6
25 COSM6903885 NOTCH2 skin,hand,carcinoma,NS c.5782-1G>A p.? 1:119918554-119918554 6
26 COSM6903832 NOTCH2 skin,hand,carcinoma,NS c.1800G>A p.M600I 1:119963689-119963689 6
27 COSM6903902 NOTCH2 skin,hand,carcinoma,NS c.6964C>T p.P2322S 1:119915758-119915758 6
28 COSM6903840 NOTCH2 skin,hand,carcinoma,NS c.2581T>G p.C861G 1:119949025-119949025 6
29 COSM6903820 NOTCH2 skin,hand,carcinoma,NS c.872C>T p.T291I 1:119986962-119986962 6
30 COSM6903869 NOTCH2 skin,hand,carcinoma,NS c.4966C>T p.Q1656* 1:119922672-119922672 6
31 COSM6903846 NOTCH2 skin,hand,carcinoma,NS c.3100T>C p.C1034R 1:119940638-119940638 6
32 COSM4891299 NOTCH2 skin,hand,carcinoma,NS c.3293G>A p.C1098Y 1:119937901-119937901 6
33 COSM6903829 NOTCH2 skin,hand,carcinoma,NS c.1640G>A p.C547Y 1:119965494-119965494 6
34 COSM6903657 NOTCH1 skin,hand,carcinoma,NS c.4022A>G p.E1341G 9:136505874-136505874 6
35 COSM6903567 NOTCH1 skin,hand,carcinoma,NS c.1433G>A p.C478Y 9:136517760-136517760 6
36 COSM6903669 NOTCH1 skin,hand,carcinoma,NS c.4160C>T p.A1387V 9:136505736-136505736 6
37 COSM3215961 NOTCH1 skin,hand,carcinoma,NS c.4411G>A p.A1471T 9:136505485-136505485 6
38 COSM6903597 NOTCH1 skin,hand,carcinoma,NS c.2536C>T p.Q846* 9:136511203-136511203 6
39 COSM6903555 NOTCH1 skin,hand,carcinoma,NS c.1280G>A p.G427D 9:136517913-136517913 6
40 COSM6903782 NOTCH1 skin,hand,carcinoma,NS c.6787C>T p.R2263W 9:136496952-136496952 6
41 COSM4493469 NOTCH1 skin,hand,carcinoma,NS c.415C>T p.Q139* 9:136523177-136523177 6
42 COSM99651 NOTCH1 skin,hand,carcinoma,NS c.1093C>T p.R365C 9:136518597-136518597 6
43 COSM6903978 NOTCH1 skin,hand,carcinoma,NS c.4435T>G p.C1479G 9:136505461-136505461 6
44 COSM5575656 NOTCH1 skin,hand,carcinoma,NS c.5057T>C p.V1686A 9:136503292-136503292 6
45 COSM120968 NOTCH1 skin,hand,carcinoma,NS c.1270G>A p.E424K 9:136517923-136517923 6
46 COSM43356 NOTCH1 skin,hand,carcinoma,NS c.6979C>T p.R2327W 9:136496760-136496760 6
47 COSM6903571 NOTCH1 skin,hand,carcinoma,NS c.1522A>T p.K508* 9:136517305-136517305 6
48 COSM6903770 NOTCH1 skin,hand,carcinoma,NS c.6160A>T p.K2054* 9:136498919-136498919 6
49 COSM6903625 NOTCH1 skin,hand,carcinoma,NS c.3172-1G>A p.? 9:136508386-136508386 6
50 COSM6903980 NOTCH1 skin,hand,carcinoma,NS c.4435T>C p.C1479R 9:136505461-136505461 6
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Expression for Eccrine Porocarcinoma

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Search GEO for disease gene expression data for Eccrine Porocarcinoma.
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Pathways for Eccrine Porocarcinoma

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Pathways related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
11.92 VIM MUC1 KRT5
2
Keratinization 66
Show member pathways
 11.79 KRT5 KRT15 KRT1
3
Interleukin-4 and 13 signaling 66
11.19 VIM STAT3 MUC1
4
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 10.83 VIM KRT5 KRT1
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GO Terms for Eccrine Porocarcinoma

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Cellular components related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 VIM MUC1 KRT5 KRT15 KRT1
2 intermediate filament GO:0005882 8.92 VIM KRT5 KRT15 KRT1

Biological processes related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.43 VIM STAT3 MUC1
2 keratinization GO:0031424 9.33 KRT5 KRT15 KRT1
3 cornification GO:0070268 9.13 KRT5 KRT15 KRT1
4 astrocyte differentiation GO:0048708 8.62 STAT3 S100B

Molecular functions related to Eccrine Porocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 VIM KRT5 KRT15
2 scaffold protein binding GO:0097110 8.8 VIM KRT5 KRT15
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Sources for Eccrine Porocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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