Eccrine Sweat Gland Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Eccrine Sweat Gland Cancer

MalaCards integrated aliases for Eccrine Sweat Gland Cancer:

Name: Eccrine Sweat Gland Cancer ¹¹ ¹⁴ ¹⁶

Malignant Eccrine Skin Neoplasm ¹¹

Malignant Eccrine Tumor ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4921

NCIt ⁴⁹ C5559

EFO ¹⁶ EFO_0005553

UMLS ⁷¹ C1334577

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Summaries for Eccrine Sweat Gland Cancer

MalaCards based summary: Eccrine Sweat Gland Cancer, also known as malignant eccrine skin neoplasm, is related to eccrine adenocarcinoma and basal cell carcinoma. An important gene associated with Eccrine Sweat Gland Cancer is NUTM1 (NUT Midline Carcinoma Family Member 1), and among its related pathways/superpathways are Nervous system development and Keratinization. Affiliated tissues include skin, and related phenotypes are neoplasm and digestive/alimentary

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Related Diseases for Eccrine Sweat Gland Cancer

Diseases related to Eccrine Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)

#	Related Disease	Score	Top Affiliating Genes
1	eccrine adenocarcinoma	32.1	PIP KRT7 KRT5 CEACAM5
2	basal cell carcinoma	28.8	TP53 PTGER4 PIP KRT7 KRT5 KRT19
3	sweat gland cancer	28.8	TP53 PIP PHLDA1 MAML2 KRT7 KRT5
4	eccrine sweat gland neoplasm	27.8	YAP1 WWTR1 PIP NUTM1 MAMLD1 MAML2
5	thymus adenocarcinoma	10.4	NUTM1 CEACAM5
6	leukoplakia of penis	10.4	KRT7 CEACAM5
7	urethral villous adenoma	10.4	KRT7 CEACAM5
8	schneiderian carcinoma	10.4	NUTM1 MAML2
9	pancreatic serous cystadenocarcinoma	10.4	KRT7 CEACAM5
10	vaginal tubulovillous adenoma	10.4	KRT7 CEACAM5
11	urinary bladder villous adenoma	10.4	KRT7 CEACAM5
12	lymphoepithelioma-like thymic carcinoma	10.3	NUTM1 KRT5
13	aortic malignant tumor	10.3	KRT7 CEACAM5
14	lacrimal gland mucoepidermoid carcinoma	10.3	MAML2 KRT7
15	female urethral cancer	10.3	KRT7 CEACAM5
16	mucinous ovarian cystadenoma	10.3	KRT7 CEACAM5
17	mucinous adenofibroma	10.3	KRT7 CEACAM5
18	laryngeal adenoid cystic carcinoma	10.3	KRT7 KRT5
19	jejunal cancer	10.3	KRT7 CEACAM5
20	colonic lymphangioma	10.3	KRT7 CEACAM5
21	internal hemorrhoid	10.3	KRT7 CEACAM5
22	inverted transitional papilloma	10.3	KRT7 KRT5
23	hemorrhoid	10.3	KRT7 CEACAM5
24	mucinous intrahepatic cholangiocarcinoma	10.3	KRT7 CEACAM5
25	lung adenoid cystic carcinoma	10.3	MAML2 KRT7
26	bile duct cystadenocarcinoma	10.3	KRT7 CEACAM5
27	rectosigmoid junction neoplasm	10.3	KRT7 CEACAM5
28	sigmoid neoplasm	10.3	KRT7 CEACAM5
29	appendiceal neoplasm	10.3	KRT7 CEACAM5
30	microinvasive cervical squamous cell carcinoma	10.3	KRT7 KRT5
31	subareolar duct papillomatosis	10.3	KRT7 KRT5
32	prostatic urethral cancer	10.3	KRT7 KRT5
33	clear cell acanthoma	10.3	KRT5 CEACAM5
34	nipple benign neoplasm	10.3	KRT7 KRT5
35	krukenberg carcinoma	10.3	KRT7 CEACAM5
36	rectum squamous cell carcinoma	10.3	KRT7 KRT5
37	middle ear adenoma	10.3	KRT7 KRT5
38	auditory system benign neoplasm	10.3	KRT7 KRT5
39	papillary squamous carcinoma	10.3	KRT7 KRT5
40	follicular infundibulum tumor	10.3	PHLDA1 KRT15
41	ascending colon cancer	10.3	KRT7 CEACAM5
42	benign breast adenomyoepithelioma	10.3	KRT7 KRT5
43	breast adenomyoepithelioma	10.3	KRT7 KRT5
44	sebaceous breast carcinoma	10.3	PIP CEACAM5
45	pilar sheath acanthoma	10.3	PHLDA1 KRT15
46	morpheaform basal cell carcinoma	10.3	PHLDA1 KRT15
47	lipoadenoma	10.3	MAML2 KRT5
48	breast myoepithelial neoplasm	10.3	KRT7 KRT5
49	epidermal appendage tumor	10.3	PHLDA1 KRT15
50	ovarian mucinous neoplasm	10.3	KRT7 CEACAM5

Graphical network of the top 20 diseases related to Eccrine Sweat Gland Cancer:

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Symptoms & Phenotypes for Eccrine Sweat Gland Cancer

MGI Mouse Phenotypes related to Eccrine Sweat Gland Cancer:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.63	CAMTA1 CEACAM5 KRT19 PTGER4 TP53 YAP1
2	digestive/alimentary	MP:0005381	9.56	CEACAM5 KRT15 KRT19 KRT5 PIP TP53
3	immune system	MP:0005387	9.32	CEACAM5 KRT19 KRT5 MAMLD1 PHLDA1 PIP

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Drugs & Therapeutics for Eccrine Sweat Gland Cancer

Search Clinical Trials, NIH Clinical Center for Eccrine Sweat Gland Cancer

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Genetic Tests for Eccrine Sweat Gland Cancer

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Anatomical Context for Eccrine Sweat Gland Cancer

Organs/tissues related to Eccrine Sweat Gland Cancer:

MalaCards : Skin

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Publications for Eccrine Sweat Gland Cancer

Articles related to Eccrine Sweat Gland Cancer:

#	Title	Authors	PMID	Year
1	Malignant eccrine tumor--a case report and a classification of tumors of eccrine sweat apparatus. ⁶²	Nakamura S...Hoshi K	2229655	1990
2	[Ultrastructural aspects of the histogenesis and diagnosis of cancer of eccrine sweat gland cancer in man]. ⁶²	Korkmazov BM	3799045	1986

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Genes for Eccrine Sweat Gland Cancer

Genes related to Eccrine Sweat Gland Cancer (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NUTM1	NUT Midline Carcinoma Family Member 1	Protein Coding	7.12	DISEASES inferred ¹⁴
2	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	6.92	DISEASES inferred ¹⁴
3	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	6.91	DISEASES inferred ¹⁴
4	KRT7	Keratin 7	Protein Coding	6.76	DISEASES inferred ¹⁴
5	KRT15	Keratin 15	Protein Coding	6.64	DISEASES inferred ¹⁴
6	KRT5	Keratin 5	Protein Coding	6.58	DISEASES inferred ¹⁴
7	PHLDA1	Pleckstrin Homology Like Domain Family A Member 1	Protein Coding	6.54	DISEASES inferred ¹⁴
8	FAM118B	Family With Sequence Similarity 118 Member B	Protein Coding	6.53	DISEASES inferred ¹⁴
9	PIP	Prolactin Induced Protein	Protein Coding	6.38	DISEASES inferred ¹⁴
10	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	6.21	DISEASES inferred ¹⁴
11	PTGER4	Prostaglandin E Receptor 4	Protein Coding	5.84	DISEASES inferred ¹⁴
12	MAMLD1	Mastermind Like Domain Containing 1	Protein Coding	5.78	DISEASES inferred ¹⁴
13	TP53	Tumor Protein P53	Protein Coding	5.72	DISEASES inferred ¹⁴
14	KRT19	Keratin 19	Protein Coding	5.69	DISEASES inferred ¹⁴
15	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	5.68	DISEASES inferred ¹⁴
16	CAMTA1	Calmodulin Binding Transcription Activator 1	Protein Coding	5.63	DISEASES inferred ¹⁴

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Variations for Eccrine Sweat Gland Cancer

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Expression for Eccrine Sweat Gland Cancer

Search GEO for disease gene expression data for Eccrine Sweat Gland Cancer.

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Pathways for Eccrine Sweat Gland Cancer

Pathways related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Nervous system development ⁶⁶ Show member pathways Axon guidance ⁶⁶ Developmental Biology ⁶⁶	12.58	YAP1 WWTR1 MAMLD1 MAML2 KRT7 KRT5
2	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.99	KRT7 KRT5 KRT19 KRT15
3	Gastrulation ⁶⁶ Show member pathways Epithelial-Mesenchymal Transition (EMT) during gastrulation ⁶⁶ Formation of axial mesoderm ⁶⁶ Formation of lateral plate mesoderm ⁶⁶ Formation of paraxial mesoderm ⁶⁶ Germ layer formation at gastrulation ⁶⁶	11.17	YAP1 MAMLD1 MAML2
4	Signaling by Hippo ⁶⁶	10.62	YAP1 WWTR1
5	YAP1- and WWTR1 (TAZ)-stimulated gene expression ⁶⁶	10.43	YAP1 WWTR1

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GO Terms for Eccrine Sweat Gland Cancer

Cellular components related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	9.23	KRT7 KRT5 KRT19 KRT15

Biological processes related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heart process	GO:0003015	9.46	YAP1 WWTR1
2	regulation of metanephric nephron tubule epithelial cell differentiation	GO:0072307	9.26	YAP1 WWTR1
3	intermediate filament organization	GO:0045109	9.23	KRT7 KRT5 KRT19 KRT15

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Sources for Eccrine Sweat Gland Cancer

¹ BitterDB

² CDC

³ Cell Signaling Technology

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²³ GeneHancer via GeneCards

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²⁶ GEO DataSets

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³¹ ICD10

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³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

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⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ECC007 MIFTS: 25	Eccrine Sweat Gland Cancer Categories: Cancer diseases, Endocrine diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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