Eccrine Sweat Gland Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Eccrine Sweat Gland Cancer

MalaCards integrated aliases for Eccrine Sweat Gland Cancer:

Name: Eccrine Sweat Gland Cancer ¹² ¹⁵ ¹⁷

Malignant Eccrine Skin Neoplasm ¹²

Malignant Eccrine Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4921

NCIt ⁵¹ C5559

EFO ¹⁷ EFO_0005553

UMLS ⁷⁴ C1334577

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Summaries for Eccrine Sweat Gland Cancer

MalaCards based summary : Eccrine Sweat Gland Cancer, also known as malignant eccrine skin neoplasm, is related to eccrine adenocarcinoma and hidrocystoma. An important gene associated with Eccrine Sweat Gland Cancer is DAND5 (DAN Domain BMP Antagonist Family Member 5), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin.

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Related Diseases for Eccrine Sweat Gland Cancer

Diseases related to Eccrine Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)

#	Related Disease	Score	Top Affiliating Genes
1	eccrine adenocarcinoma	11.4
2	hidrocystoma	10.2	KRT15 KRT7
3	cell type benign neoplasm	10.2	KRT7 TP53
4	malignant ovarian surface epithelial-stromal neoplasm	10.2	KRT7 TP53
5	ovary epithelial cancer	10.2	KRT7 TP53
6	endometrial adenocarcinoma	10.2	KRT7 TP53
7	large cell carcinoma	10.2	KRT5 KRT7
8	carcinosarcoma	10.2	KRT7 TP53
9	bile duct cancer	10.2	KRT7 TP53
10	spiradenoma	10.2	KRT7 TP53
11	conjunctival squamous cell carcinoma	10.2	KRT15 TP53
12	teratoma	10.2	KRT7 TP53
13	apocrine adenocarcinoma	10.2	KRT15 KRT5
14	inverted transitional papilloma	10.2	KRT5 KRT7
15	balloon cell malignant melanoma	10.2	KRT5 KRT7
16	benign breast adenomyoepithelioma	10.2	KRT5 KRT7
17	breast adenomyoepithelioma	10.2	KRT5 KRT7
18	ceruminoma	10.2	KRT5 KRT7
19	benign mesothelioma	10.2	KRT5 KRT7
20	vulvar intraepithelial neoplasia	10.2	KRT7 TP53
21	sensory organ benign neoplasm	10.2	KRT5 KRT7
22	bile duct mucoepidermoid carcinoma	10.2	KRT5 KRT7
23	middle ear adenoma	10.2	KRT5 KRT7
24	large cell acanthoma	10.2	KRT5 KRT7
25	ductal carcinoma in situ	10.2	KRT5 TP53
26	cystadenocarcinoma	10.2	KRT7 TP53
27	bladder carcinoma in situ	10.2	KRT7 TP53
28	vulvar disease	10.2	KRT7 TP53
29	nasal cavity adenocarcinoma	10.2	KRT7 TP53
30	female reproductive endometrioid cancer	10.2	KRT7 TP53
31	malignant biphasic mesothelioma	10.2	KRT5 KRT7
32	peritoneum cancer	10.1	KRT5 KRT7
33	gastric squamous cell carcinoma	10.1	KRT5 KRT7
34	pleomorphic carcinoma	10.1	KRT7 TP53
35	breast myoepithelial neoplasm	10.1	KRT5 KRT7
36	eccrine porocarcinoma	10.1	KRT15 LGR6
37	keratinizing squamous cell carcinoma	10.1	KRT5 TP53
38	lipoadenoma	10.1	KRT5 KRT7
39	nasal cavity squamous cell carcinoma	10.1	KRT5 KRT7
40	atypical choroid plexus papilloma	10.1	KRT5 KRT7
41	breast secretory carcinoma	10.1	KRT5 KRT7
42	epithelial-myoepithelial carcinoma	10.1	KRT7 TP53
43	breast squamous cell carcinoma	10.1	KRT5 TP53
44	pregnancy adenoma	10.1	KRT5 KRT7
45	basaloid squamous cell carcinoma	10.1	KRT7 TP53
46	anus cancer	10.1	KRT5 KRT7
47	mixed cell type cancer	10.1	KRT7 TP53
48	granulosa cell tumor of the ovary	10.1	KRT7 TP53
49	acinar cell carcinoma	10.1	KRT7 TP53
50	intraneural perineurioma	10.1	KRT5 KRT7

Graphical network of the top 20 diseases related to Eccrine Sweat Gland Cancer:

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Symptoms & Phenotypes for Eccrine Sweat Gland Cancer

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Drugs & Therapeutics for Eccrine Sweat Gland Cancer

Search Clinical Trials , NIH Clinical Center for Eccrine Sweat Gland Cancer

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Genetic Tests for Eccrine Sweat Gland Cancer

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Anatomical Context for Eccrine Sweat Gland Cancer

MalaCards organs/tissues related to Eccrine Sweat Gland Cancer:

⁴²

Skin

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Publications for Eccrine Sweat Gland Cancer

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Genes for Eccrine Sweat Gland Cancer

Genes related to Eccrine Sweat Gland Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DAND5	DAN Domain BMP Antagonist Family Member 5	Protein Coding	17.17	DISEASES inferred ¹⁵
2	KRT15	Keratin 15	Protein Coding	16.38	DISEASES inferred ¹⁵
3	KRT7	Keratin 7	Protein Coding	15.64	DISEASES inferred ¹⁵
4	KRT5	Keratin 5	Protein Coding	14.82	DISEASES inferred ¹⁵
5	LGR6	Leucine Rich Repeat Containing G Protein-Coupled Receptor 6	Protein Coding	14.75	DISEASES inferred ¹⁵
6	KRT20	Keratin 20	Protein Coding	14.68	DISEASES inferred ¹⁵
7	TP53	Tumor Protein P53	Protein Coding	14.67	DISEASES inferred ¹⁵

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Variations for Eccrine Sweat Gland Cancer

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Expression for Eccrine Sweat Gland Cancer

Search GEO for disease gene expression data for Eccrine Sweat Gland Cancer.

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Pathways for Eccrine Sweat Gland Cancer

Pathways related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁷ Show member pathways Axon guidance ⁶⁷	12.57	DAND5 KRT15 KRT20 KRT5 KRT7
2	Cytoskeletal Signaling ⁴	11.82	KRT20 KRT5 KRT7
3	Keratinization ⁶⁷ Show member pathways Formation of the cornified envelope ⁶⁷	11.38	KRT15 KRT20 KRT5 KRT7

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GO Terms for Eccrine Sweat Gland Cancer

Cellular components related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	8.92	KRT15 KRT20 KRT5 KRT7

Biological processes related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	keratinization	GO:0031424	9.26	KRT15 KRT20 KRT5 KRT7
2	cornification	GO:0070268	8.92	KRT15 KRT20 KRT5 KRT7

Molecular functions related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	scaffold protein binding	GO:0097110	8.96	KRT15 KRT5
2	structural constituent of cytoskeleton	GO:0005200	8.8	KRT15 KRT20 KRT5

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Sources for Eccrine Sweat Gland Cancer

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