MCID: ECC007
MIFTS: 24

Eccrine Sweat Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Eccrine Sweat Gland Cancer

MalaCards integrated aliases for Eccrine Sweat Gland Cancer:

Name: Eccrine Sweat Gland Cancer 12 15 17
Malignant Eccrine Skin Neoplasm 12
Malignant Eccrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4921
NCIt 50 C5559
UMLS 72 C1334577

Summaries for Eccrine Sweat Gland Cancer

MalaCards based summary : Eccrine Sweat Gland Cancer, also known as malignant eccrine skin neoplasm, is related to eccrine acrospiroma and papillary adenocarcinoma. An important gene associated with Eccrine Sweat Gland Cancer is DAND5 (DAN Domain BMP Antagonist Family Member 5), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin.

Related Diseases for Eccrine Sweat Gland Cancer

Diseases related to Eccrine Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 eccrine acrospiroma 30.4 KRT17 KRT15
2 papillary adenocarcinoma 30.1 TP53 KRT7
3 sweat gland cancer 28.3 TP53 KRT7 KRT5 KRT20 KRT15
4 basal cell carcinoma 27.9 TP53 KRT7 KRT20 KRT17 KRT15
5 eccrine adenocarcinoma 11.5
6 hidrocystoma 10.5 KRT7 KRT15
7 apocrine adenocarcinoma 10.4 KRT5 KRT15
8 inverted transitional papilloma 10.4 KRT7 KRT5
9 ceruminoma 10.4 KRT7 KRT5
10 benign breast adenomyoepithelioma 10.4 KRT7 KRT5
11 breast adenomyoepithelioma 10.4 KRT7 KRT5
12 balloon cell malignant melanoma 10.4 KRT7 KRT5
13 benign mesothelioma 10.4 KRT7 KRT5
14 middle ear adenoma 10.4 KRT7 KRT5
15 bile duct mucoepidermoid carcinoma 10.4 KRT7 KRT5
16 sensory organ benign neoplasm 10.4 KRT7 KRT5
17 eccrine porocarcinoma 10.4 LGR6 KRT15
18 nodular basal cell carcinoma 10.4 KRT17 KRT15
19 clear cell basal cell carcinoma 10.4 KRT7 KRT17
20 malignant biphasic mesothelioma 10.4 KRT7 KRT5
21 gastric squamous cell carcinoma 10.4 KRT7 KRT5
22 peritoneum cancer 10.4 KRT7 KRT5
23 breast myoepithelial neoplasm 10.4 KRT7 KRT5
24 nasal cavity squamous cell carcinoma 10.4 KRT7 KRT5
25 lipoadenoma 10.4 KRT7 KRT5
26 breast secretory carcinoma 10.3 KRT7 KRT5
27 atypical choroid plexus papilloma 10.3 KRT7 KRT5
28 bowen's disease 10.3 KRT7 KRT17
29 anus cancer 10.3 KRT7 KRT5
30 intraneural perineurioma 10.3 KRT7 KRT5
31 spiradenoma 10.3 TP53 KRT7
32 conjunctival squamous cell carcinoma 10.3 TP53 KRT15
33 vulvar intraepithelial neoplasia 10.3 TP53 KRT7
34 bladder carcinoma in situ 10.2 TP53 KRT7
35 cystadenocarcinoma 10.2 TP53 KRT7
36 spindle cell carcinoma 10.2 KRT7 KRT5
37 nasal cavity adenocarcinoma 10.2 TP53 KRT7
38 vulvar disease 10.2 TP53 KRT7
39 female reproductive endometrioid cancer 10.2 TP53 KRT7
40 keratinizing squamous cell carcinoma 10.2 TP53 KRT5
41 pleomorphic carcinoma 10.2 TP53 KRT7
42 breast squamous cell carcinoma 10.2 TP53 KRT5
43 epithelial-myoepithelial carcinoma 10.2 TP53 KRT7
44 granulosa cell tumor of the ovary 10.2 TP53 KRT7
45 mixed cell type cancer 10.2 TP53 KRT7
46 keratosis, seborrheic 10.2 KRT5 KRT17
47 acinar cell carcinoma 10.1 TP53 KRT7
48 vulva cancer 10.1 TP53 KRT7
49 vulva squamous cell carcinoma 10.1 TP53 KRT17
50 bile duct adenocarcinoma 10.1 TP53 KRT7

Graphical network of the top 20 diseases related to Eccrine Sweat Gland Cancer:



Diseases related to Eccrine Sweat Gland Cancer

Symptoms & Phenotypes for Eccrine Sweat Gland Cancer

Drugs & Therapeutics for Eccrine Sweat Gland Cancer

Search Clinical Trials , NIH Clinical Center for Eccrine Sweat Gland Cancer

Genetic Tests for Eccrine Sweat Gland Cancer

Anatomical Context for Eccrine Sweat Gland Cancer

MalaCards organs/tissues related to Eccrine Sweat Gland Cancer:

41
Skin

Publications for Eccrine Sweat Gland Cancer

Articles related to Eccrine Sweat Gland Cancer:

# Title Authors PMID Year
1
Malignant eccrine tumor--a case report and a classification of tumors of eccrine sweat apparatus. 38
2229655 1990
2
[Ultrastructural aspects of the histogenesis and diagnosis of cancer of eccrine sweat gland cancer in man]. 38
3799045 1986

Variations for Eccrine Sweat Gland Cancer

Expression for Eccrine Sweat Gland Cancer

Search GEO for disease gene expression data for Eccrine Sweat Gland Cancer.

Pathways for Eccrine Sweat Gland Cancer

Pathways related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 KRT7 KRT5 KRT20 KRT17 KRT15 DAND5
2 11.75 KRT7 KRT5 KRT20 KRT17
3
Show member pathways
11.53 KRT7 KRT5 KRT17
4
Show member pathways
11.48 KRT7 KRT5 KRT20 KRT17 KRT15
5 11.35 TP53 KRT5 KRT17

GO Terms for Eccrine Sweat Gland Cancer

Cellular components related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.02 KRT7 KRT5 KRT20 KRT17 KRT15

Biological processes related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT7 KRT5 KRT20 KRT17 KRT15
2 epidermis development GO:0008544 9.33 KRT5 KRT17 KRT15
3 cytoskeleton organization GO:0007010 9.32 KRT5 KRT15
4 intermediate filament organization GO:0045109 9.26 KRT20 KRT17
5 cornification GO:0070268 9.02 KRT7 KRT5 KRT20 KRT17 KRT15

Molecular functions related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.96 KRT5 KRT15
2 structural constituent of cytoskeleton GO:0005200 8.92 KRT5 KRT20 KRT17 KRT15

Sources for Eccrine Sweat Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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