Eccrine Sweat Gland Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Eccrine Sweat Gland Cancer

MalaCards integrated aliases for Eccrine Sweat Gland Cancer:

Name: Eccrine Sweat Gland Cancer ¹² ¹⁵ ¹⁷

Malignant Eccrine Skin Neoplasm ¹²

Malignant Eccrine Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4921

NCIt ⁵⁰ C5559

EFO ¹⁷ EFO_0005553

UMLS ⁷² C1334577

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Summaries for Eccrine Sweat Gland Cancer

MalaCards based summary : Eccrine Sweat Gland Cancer, also known as malignant eccrine skin neoplasm, is related to eccrine acrospiroma and papillary adenocarcinoma. An important gene associated with Eccrine Sweat Gland Cancer is DAND5 (DAN Domain BMP Antagonist Family Member 5), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin.

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Related Diseases for Eccrine Sweat Gland Cancer

Diseases related to Eccrine Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)

#	Related Disease	Score	Top Affiliating Genes
1	eccrine acrospiroma	30.4	KRT17 KRT15
2	papillary adenocarcinoma	30.1	TP53 KRT7
3	sweat gland cancer	28.3	TP53 KRT7 KRT5 KRT20 KRT15
4	basal cell carcinoma	27.9	TP53 KRT7 KRT20 KRT17 KRT15
5	eccrine adenocarcinoma	11.5
6	hidrocystoma	10.5	KRT7 KRT15
7	apocrine adenocarcinoma	10.4	KRT5 KRT15
8	inverted transitional papilloma	10.4	KRT7 KRT5
9	ceruminoma	10.4	KRT7 KRT5
10	benign breast adenomyoepithelioma	10.4	KRT7 KRT5
11	breast adenomyoepithelioma	10.4	KRT7 KRT5
12	balloon cell malignant melanoma	10.4	KRT7 KRT5
13	benign mesothelioma	10.4	KRT7 KRT5
14	middle ear adenoma	10.4	KRT7 KRT5
15	bile duct mucoepidermoid carcinoma	10.4	KRT7 KRT5
16	sensory organ benign neoplasm	10.4	KRT7 KRT5
17	eccrine porocarcinoma	10.4	LGR6 KRT15
18	nodular basal cell carcinoma	10.4	KRT17 KRT15
19	clear cell basal cell carcinoma	10.4	KRT7 KRT17
20	malignant biphasic mesothelioma	10.4	KRT7 KRT5
21	gastric squamous cell carcinoma	10.4	KRT7 KRT5
22	peritoneum cancer	10.4	KRT7 KRT5
23	breast myoepithelial neoplasm	10.4	KRT7 KRT5
24	nasal cavity squamous cell carcinoma	10.4	KRT7 KRT5
25	lipoadenoma	10.4	KRT7 KRT5
26	breast secretory carcinoma	10.3	KRT7 KRT5
27	atypical choroid plexus papilloma	10.3	KRT7 KRT5
28	bowen's disease	10.3	KRT7 KRT17
29	anus cancer	10.3	KRT7 KRT5
30	intraneural perineurioma	10.3	KRT7 KRT5
31	spiradenoma	10.3	TP53 KRT7
32	conjunctival squamous cell carcinoma	10.3	TP53 KRT15
33	vulvar intraepithelial neoplasia	10.3	TP53 KRT7
34	bladder carcinoma in situ	10.2	TP53 KRT7
35	cystadenocarcinoma	10.2	TP53 KRT7
36	spindle cell carcinoma	10.2	KRT7 KRT5
37	nasal cavity adenocarcinoma	10.2	TP53 KRT7
38	vulvar disease	10.2	TP53 KRT7
39	female reproductive endometrioid cancer	10.2	TP53 KRT7
40	keratinizing squamous cell carcinoma	10.2	TP53 KRT5
41	pleomorphic carcinoma	10.2	TP53 KRT7
42	breast squamous cell carcinoma	10.2	TP53 KRT5
43	epithelial-myoepithelial carcinoma	10.2	TP53 KRT7
44	granulosa cell tumor of the ovary	10.2	TP53 KRT7
45	mixed cell type cancer	10.2	TP53 KRT7
46	keratosis, seborrheic	10.2	KRT5 KRT17
47	acinar cell carcinoma	10.1	TP53 KRT7
48	vulva cancer	10.1	TP53 KRT7
49	vulva squamous cell carcinoma	10.1	TP53 KRT17
50	bile duct adenocarcinoma	10.1	TP53 KRT7

Graphical network of the top 20 diseases related to Eccrine Sweat Gland Cancer:

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Symptoms & Phenotypes for Eccrine Sweat Gland Cancer

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Drugs & Therapeutics for Eccrine Sweat Gland Cancer

Search Clinical Trials , NIH Clinical Center for Eccrine Sweat Gland Cancer

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Genetic Tests for Eccrine Sweat Gland Cancer

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Anatomical Context for Eccrine Sweat Gland Cancer

MalaCards organs/tissues related to Eccrine Sweat Gland Cancer:

⁴¹

Skin

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Publications for Eccrine Sweat Gland Cancer

Articles related to Eccrine Sweat Gland Cancer:

#	Title	Authors	PMID	Year
1	Malignant eccrine tumor--a case report and a classification of tumors of eccrine sweat apparatus. ³⁸	Nakamura S...Hoshi K	2229655	1990
2	[Ultrastructural aspects of the histogenesis and diagnosis of cancer of eccrine sweat gland cancer in man]. ³⁸	Korkmazov BM	3799045	1986

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Genes for Eccrine Sweat Gland Cancer

Genes related to Eccrine Sweat Gland Cancer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DAND5	DAN Domain BMP Antagonist Family Member 5	Protein Coding	17.19	DISEASES inferred ¹⁵
2	KRT15	Keratin 15	Protein Coding	16.25	DISEASES inferred ¹⁵
3	KRT7	Keratin 7	Protein Coding	15.48	DISEASES inferred ¹⁵
4	KRT5	Keratin 5	Protein Coding	15.31	DISEASES inferred ¹⁵
5	KRT17	Keratin 17	Protein Coding	14.93	DISEASES inferred ¹⁵
6	TP53	Tumor Protein P53	Protein Coding	14.9	DISEASES inferred ¹⁵
7	KRT20	Keratin 20	Protein Coding	14.85	DISEASES inferred ¹⁵
8	LGR6	Leucine Rich Repeat Containing G Protein-Coupled Receptor 6	Protein Coding	14.55	DISEASES inferred ¹⁵

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Variations for Eccrine Sweat Gland Cancer

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Expression for Eccrine Sweat Gland Cancer

Search GEO for disease gene expression data for Eccrine Sweat Gland Cancer.

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Pathways for Eccrine Sweat Gland Cancer

Pathways related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	12.84	KRT7 KRT5 KRT20 KRT17 KRT15 DAND5
2	Cytoskeletal Signaling ⁴	11.75	KRT7 KRT5 KRT20 KRT17
3	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.53	KRT7 KRT5 KRT17
4	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.48	KRT7 KRT5 KRT20 KRT17 KRT15
5	Glucocorticoid receptor regulatory network ¹	11.35	TP53 KRT5 KRT17

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GO Terms for Eccrine Sweat Gland Cancer

Cellular components related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	9.02	KRT7 KRT5 KRT20 KRT17 KRT15

Biological processes related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	keratinization	GO:0031424	9.35	KRT7 KRT5 KRT20 KRT17 KRT15
2	epidermis development	GO:0008544	9.33	KRT5 KRT17 KRT15
3	cytoskeleton organization	GO:0007010	9.32	KRT5 KRT15
4	intermediate filament organization	GO:0045109	9.26	KRT20 KRT17
5	cornification	GO:0070268	9.02	KRT7 KRT5 KRT20 KRT17 KRT15

Molecular functions related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	scaffold protein binding	GO:0097110	8.96	KRT5 KRT15
2	structural constituent of cytoskeleton	GO:0005200	8.92	KRT5 KRT20 KRT17 KRT15

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Sources for Eccrine Sweat Gland Cancer

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