Eccrine Sweat Gland Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Eccrine Sweat Gland Cancer

MalaCards integrated aliases for Eccrine Sweat Gland Cancer:

Name: Eccrine Sweat Gland Cancer ¹² ¹⁵ ¹⁷

Malignant Eccrine Skin Neoplasm ¹²

Malignant Eccrine Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4921

NCIt ⁴⁹ C5559

EFO ¹⁷ EFO_0005553

UMLS ⁷¹ C1334577

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Summaries for Eccrine Sweat Gland Cancer

MalaCards based summary : Eccrine Sweat Gland Cancer, also known as malignant eccrine skin neoplasm, is related to eccrine adenocarcinoma and clear cell hidradenoma. An important gene associated with Eccrine Sweat Gland Cancer is CLEC2A (C-Type Lectin Domain Family 2 Member A), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include breast, skin and lung.

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Related Diseases for Eccrine Sweat Gland Cancer

Diseases related to Eccrine Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 341)

#	Related Disease	Score	Top Affiliating Genes
1	eccrine adenocarcinoma	32.5	PIP KRT7 CEACAM5
2	clear cell hidradenoma	29.6	PIP KRT7 KRT5 CEACAM5
3	papillary adenocarcinoma	28.8	TP53 PIP KRT7 KRT19 CEACAM5
4	eccrine acrospiroma	27.6	TP53 PIP KRT7 KRT5 KRT19 KRT15
5	basal cell carcinoma	27.0	TP53 PHLDA1 KRT7 KRT5 KRT20 KRT19
6	sweat gland cancer	26.6	TP53 PIP PHLDA1 KRT7 KRT5 KRT20
7	ovarian cystadenoma	10.5	KRT7 CEACAM5
8	cutaneous mucoepidermoid carcinoma	10.4	KRT7 CEACAM5
9	mucinous adenofibroma	10.4	KRT7 CEACAM5
10	sigmoid neoplasm	10.4	KRT7 CEACAM5
11	inverted follicular keratosis	10.4	PHLDA1 CLEC2A
12	mucinous intrahepatic cholangiocarcinoma	10.4	KRT7 CEACAM5
13	pilar sheath acanthoma	10.4	PHLDA1 CLEC2A
14	appendiceal neoplasm	10.4	KRT7 CEACAM5
15	biliary papillomatosis	10.4	KRT7 CEACAM5
16	liver sarcoma	10.4	KRT7 CEACAM5
17	warthin tumor	10.4	KRT7 CEACAM5
18	vulvar syringoma	10.4	PIP CEACAM5
19	anal canal paget's disease	10.4	PIP KRT7
20	anal gland adenocarcinoma	10.4	PIP KRT7
21	sebaceous gland neoplasm	10.4	KRT15 CLEC2A
22	fox-fordyce disease	10.4	PIP CEACAM5
23	bartholin's gland carcinoma	10.3	PIP KRT7
24	oncocytic breast carcinoma	10.3	PIP KRT7
25	eccrine papillary adenoma	10.3	PIP CEACAM5
26	breast cystic hypersecretory carcinoma	10.3	KRT5 CEACAM5
27	bartholin's gland disease	10.3	PIP KRT7
28	gallbladder squamous cell carcinoma	10.3	KRT5 CEACAM5
29	inverted transitional papilloma	10.3	KRT7 KRT5
30	submandibular gland cancer	10.3	PIP KRT7
31	secretory meningioma	10.3	KRT7 CEACAM5
32	benign breast adenomyoepithelioma	10.3	KRT7 KRT5
33	breast adenomyoepithelioma	10.3	KRT7 KRT5
34	vulva basal cell carcinoma	10.3	KRT5 CEACAM5
35	subareolar duct papillomatosis	10.3	KRT7 KRT5
36	bone leiomyosarcoma	10.3	KRT7 KRT5
37	nipple neoplasm	10.3	KRT7 KRT5
38	microinvasive cervical squamous cell carcinoma	10.3	KRT7 KRT5
39	ovarian germ cell cancer	10.3	KRT7 CEACAM5
40	hair follicle neoplasm	10.3	KRT15 CLEC2A
41	gastric squamous cell carcinoma	10.3	KRT7 KRT5
42	middle ear adenoma	10.3	KRT7 KRT5
43	breast myoepithelial neoplasm	10.3	KRT7 KRT5
44	sensory organ benign neoplasm	10.3	KRT7 KRT5
45	proliferating trichilemmal cyst	10.3	KRT7 KRT19
46	breast metaplastic carcinoma	10.3	KRT7 KRT5
47	breast hemangiopericytoma	10.3	KRT7 KRT19
48	anus basaloid carcinoma	10.3	PTGER4 KRT7
49	middle ear adenocarcinoma	10.3	KRT7 KRT5
50	papillary thymic adenocarcinoma	10.3	PTGER4 CEACAM5

Graphical network of the top 20 diseases related to Eccrine Sweat Gland Cancer:

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Symptoms & Phenotypes for Eccrine Sweat Gland Cancer

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Drugs & Therapeutics for Eccrine Sweat Gland Cancer

Search Clinical Trials , NIH Clinical Center for Eccrine Sweat Gland Cancer

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Genetic Tests for Eccrine Sweat Gland Cancer

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Anatomical Context for Eccrine Sweat Gland Cancer

MalaCards organs/tissues related to Eccrine Sweat Gland Cancer:

⁴⁰

Breast, Skin, Lung, Thymus, Colon, Liver, Thyroid

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Publications for Eccrine Sweat Gland Cancer

Articles related to Eccrine Sweat Gland Cancer:

#	Title	Authors	PMID	Year
1	Malignant eccrine tumor--a case report and a classification of tumors of eccrine sweat apparatus. ⁶¹	Nakamura S...Hoshi K	2229655	1990
2	[Ultrastructural aspects of the histogenesis and diagnosis of cancer of eccrine sweat gland cancer in man]. ⁶¹	Korkmazov BM	3799045	1986

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Genes for Eccrine Sweat Gland Cancer

Genes related to Eccrine Sweat Gland Cancer (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CLEC2A	C-Type Lectin Domain Family 2 Member A	Protein Coding	8.02	DISEASES inferred ¹⁵
2	DAND5	DAN Domain BMP Antagonist Family Member 5	Protein Coding	7.43	DISEASES inferred ¹⁵
3	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	7.33	DISEASES inferred ¹⁵
4	KRT7	Keratin 7	Protein Coding	6.85	DISEASES inferred ¹⁵
5	KRT15	Keratin 15	Protein Coding	6.8	DISEASES inferred ¹⁵
6	PHLDA1	Pleckstrin Homology Like Domain Family A Member 1	Protein Coding	6.58	DISEASES inferred ¹⁵
7	PIP	Prolactin Induced Protein	Protein Coding	6.47	DISEASES inferred ¹⁵
8	KRT5	Keratin 5	Protein Coding	6.45	DISEASES inferred ¹⁵
9	PTGER4	Prostaglandin E Receptor 4	Protein Coding	6.24	DISEASES inferred ¹⁵
10	TP53	Tumor Protein P53	Protein Coding	5.96	DISEASES inferred ¹⁵
11	KRT20	Keratin 20	Protein Coding	5.94	DISEASES inferred ¹⁵
12	KRT19	Keratin 19	Protein Coding	5.77	DISEASES inferred ¹⁵

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Variations for Eccrine Sweat Gland Cancer

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Expression for Eccrine Sweat Gland Cancer

Search GEO for disease gene expression data for Eccrine Sweat Gland Cancer.

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Pathways for Eccrine Sweat Gland Cancer

Pathways related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.01	KRT7 KRT5 KRT20 KRT19 KRT15 DAND5
2	Cytoskeletal Signaling ⁴	11.75	KRT7 KRT5 KRT20 KRT19
3	Keratinization ⁶⁵ Show member pathways Formation of the cornified envelope ⁶⁵	11.48	KRT7 KRT5 KRT20 KRT19 KRT15
4	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.47	KRT7 KRT5 KRT19
5	Staphylococcus aureus infection ³⁶	11.31	KRT20 KRT19 KRT15

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GO Terms for Eccrine Sweat Gland Cancer

Cellular components related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	9.02	KRT7 KRT5 KRT20 KRT19 KRT15

Biological processes related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	keratinization	GO:0031424	9.35	KRT7 KRT5 KRT20 KRT19 KRT15
2	cornification	GO:0070268	9.02	KRT7 KRT5 KRT20 KRT19 KRT15

Molecular functions related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of cytoskeleton	GO:0005200	8.92	KRT5 KRT20 KRT19 KRT15

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