MCID: ECC007
MIFTS: 23

Eccrine Sweat Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Eccrine Sweat Gland Cancer

MalaCards integrated aliases for Eccrine Sweat Gland Cancer:

Name: Eccrine Sweat Gland Cancer 12 15 17
Malignant Eccrine Skin Neoplasm 12
Malignant Eccrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4921
NCIt 49 C5559
UMLS 71 C1334577

Summaries for Eccrine Sweat Gland Cancer

MalaCards based summary : Eccrine Sweat Gland Cancer, also known as malignant eccrine skin neoplasm, is related to eccrine adenocarcinoma and clear cell hidradenoma. An important gene associated with Eccrine Sweat Gland Cancer is CLEC2A (C-Type Lectin Domain Family 2 Member A), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include skin.

Related Diseases for Eccrine Sweat Gland Cancer

Diseases related to Eccrine Sweat Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 360)
# Related Disease Score Top Affiliating Genes
1 eccrine adenocarcinoma 32.1 PIP KRT7 KRT5 CEACAM5
2 clear cell hidradenoma 29.5 PIP KRT7 KRT5 CLEC2A CEACAM5
3 papillary adenocarcinoma 28.9 TP53 PIP KRT7 KRT19 CEACAM5
4 eccrine acrospiroma 28.4 PIP KRT7 KRT5 KRT19 KRT15 CLEC2A
5 basal cell carcinoma 27.3 TP53 PHLDA1 KRT7 KRT5 KRT20 KRT19
6 sweat gland cancer 27.3 TP53 PIP KRT7 KRT5 KRT20 KRT19
7 renal pelvis transitional cell carcinoma 10.5 KRT7 CLEC2A
8 leukoplakia of penis 10.5 KRT7 CEACAM5
9 mucinous adenofibroma 10.5 KRT7 CEACAM5
10 mucinous intrahepatic cholangiocarcinoma 10.4 KRT7 CEACAM5
11 biliary papillomatosis 10.4 KRT7 CEACAM5
12 adenoid basal cell carcinoma 10.4 KRT7 CEACAM5
13 appendiceal neoplasm 10.4 KRT7 CEACAM5
14 breast cystic hypersecretory carcinoma 10.4 KRT5 CEACAM5
15 ureter squamous cell carcinoma 10.4 KRT7 KRT5
16 inverted follicular keratosis 10.4 PHLDA1 CLEC2A
17 gallbladder squamous cell carcinoma 10.4 KRT5 CEACAM5
18 pilar sheath acanthoma 10.4 PHLDA1 CLEC2A
19 inverted transitional papilloma 10.4 KRT7 KRT5
20 liver sarcoma 10.4 KRT7 CEACAM5
21 lipid-rich breast carcinoma 10.4 KRT5 CEACAM5
22 vulva basal cell carcinoma 10.4 KRT5 CEACAM5
23 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
24 subareolar duct papillomatosis 10.4 KRT7 KRT5
25 nipple benign neoplasm 10.4 KRT7 KRT5
26 benign breast adenomyoepithelioma 10.4 KRT7 KRT5
27 auditory system benign neoplasm 10.4 KRT7 KRT5
28 colon leiomyosarcoma 10.4 KRT5 CEACAM5
29 warthin tumor 10.4 KRT7 CEACAM5
30 middle ear adenoma 10.4 KRT7 KRT5
31 lung clear cell carcinoma 10.4 KRT7 KRT5
32 gastric squamous cell carcinoma 10.4 KRT7 KRT5
33 sebaceous gland neoplasm 10.4 KRT15 CLEC2A
34 eccrine papillary adenoma 10.4 PIP CEACAM5
35 sensory organ benign neoplasm 10.4 KRT7 KRT5
36 vulvar syringoma 10.4 PIP CEACAM5
37 middle ear adenocarcinoma 10.4 KRT7 KRT5
38 fox-fordyce disease 10.4 PIP CEACAM5
39 malignant biphasic mesothelioma 10.4 KRT7 KRT5
40 anal canal paget's disease 10.4 PIP KRT7
41 epidermal appendage tumor 10.4 PHLDA1 KRT15
42 oncocytic breast carcinoma 10.4 PIP KRT7
43 bartholin's gland carcinoma 10.4 PIP KRT7
44 micronodular basal cell carcinoma 10.4 KRT5 KRT15
45 apocrine adenoma 10.4 PIP KRT7
46 papillary squamous carcinoma 10.4 KRT7 KRT5
47 balloon cell malignant melanoma 10.3 KRT7 KRT5
48 bartholin's gland disease 10.3 PIP KRT7
49 malignant epithelial mesothelioma 10.3 PTGER4 CEACAM5
50 cystadenofibroma 10.3 KRT7 KRT5

Graphical network of the top 20 diseases related to Eccrine Sweat Gland Cancer:



Diseases related to Eccrine Sweat Gland Cancer

Symptoms & Phenotypes for Eccrine Sweat Gland Cancer

Drugs & Therapeutics for Eccrine Sweat Gland Cancer

Search Clinical Trials , NIH Clinical Center for Eccrine Sweat Gland Cancer

Genetic Tests for Eccrine Sweat Gland Cancer

Anatomical Context for Eccrine Sweat Gland Cancer

MalaCards organs/tissues related to Eccrine Sweat Gland Cancer:

40
Skin

Publications for Eccrine Sweat Gland Cancer

Articles related to Eccrine Sweat Gland Cancer:

# Title Authors PMID Year
1
Malignant eccrine tumor--a case report and a classification of tumors of eccrine sweat apparatus. 61
2229655 1990
2
[Ultrastructural aspects of the histogenesis and diagnosis of cancer of eccrine sweat gland cancer in man]. 61
3799045 1986

Variations for Eccrine Sweat Gland Cancer

Expression for Eccrine Sweat Gland Cancer

Search GEO for disease gene expression data for Eccrine Sweat Gland Cancer.

Pathways for Eccrine Sweat Gland Cancer

Pathways related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 KRT7 KRT5 KRT20 KRT19 KRT15 DAND5
2 11.75 KRT7 KRT5 KRT20 KRT19
3
Show member pathways
11.48 KRT7 KRT5 KRT20 KRT19 KRT15
4
Show member pathways
11.47 KRT7 KRT5 KRT19
5 11.31 KRT20 KRT19 KRT15

GO Terms for Eccrine Sweat Gland Cancer

Cellular components related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.02 KRT7 KRT5 KRT20 KRT19 KRT15

Biological processes related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT7 KRT5 KRT20 KRT19 KRT15
2 negative regulation of T cell apoptotic process GO:0070233 9.16 PIP DOCK8
3 cornification GO:0070268 9.02 KRT7 KRT5 KRT20 KRT19 KRT15

Molecular functions related to Eccrine Sweat Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.92 KRT5 KRT20 KRT19 KRT15

Sources for Eccrine Sweat Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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