MCID: ECC008
MIFTS: 28

Eccrine Sweat Gland Neoplasm

Categories: Cancer diseases, Endocrine diseases, Skin diseases

Aliases & Classifications for Eccrine Sweat Gland Neoplasm

MalaCards integrated aliases for Eccrine Sweat Gland Neoplasm:

Name: Eccrine Sweat Gland Neoplasm 12 15
Malignant Eccrine Neoplasm 70
Eccrine Skin Neoplasm 12
Eccrine Neoplasm 70
Eccrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:173
NCIt 50 C6796
UMLS 70 C1333371 C1334577

Summaries for Eccrine Sweat Gland Neoplasm

MalaCards based summary : Eccrine Sweat Gland Neoplasm, also known as malignant eccrine neoplasm, is related to eccrine sweat gland cancer and syringoma. An important gene associated with Eccrine Sweat Gland Neoplasm is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include breast, skin and lung, and related phenotype is digestive/alimentary.

Related Diseases for Eccrine Sweat Gland Neoplasm

Diseases related to Eccrine Sweat Gland Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 eccrine sweat gland cancer 30.5 PIP NUTM1 MAML2 KRT7 KRT5 KRT19
2 syringoma 29.8 KRT7 KRT19 CEACAM5
3 eccrine papillary adenoma 29.7 PIP KRT7 KRT5 KRT19 KRT17 KRT15
4 basal cell carcinoma 27.7 KRT7 KRT5 KRT19 KRT17 KRT15 KRT14
5 schneiderian carcinoma 10.4 NUTM1 MAML2
6 fox-fordyce disease 10.3 PIP CEACAM5
7 vulvar eccrine porocarcinoma 10.3 PIP CEACAM5
8 leukoplakia of penis 10.3 KRT7 CEACAM5
9 urethral villous adenoma 10.3 KRT7 CEACAM5
10 mucinous adenofibroma 10.3 KRT7 CEACAM5
11 pancreatic foamy gland adenocarcinoma 10.3 KRT7 CEACAM5
12 pancreatic serous cystadenocarcinoma 10.3 KRT7 CEACAM5
13 urinary bladder villous adenoma 10.3 KRT7 CEACAM5
14 vaginal tubulovillous adenoma 10.3 KRT7 CEACAM5
15 female urethral cancer 10.3 KRT7 CEACAM5
16 bile duct cystadenocarcinoma 10.3 KRT7 CEACAM5
17 mucinous ovarian cystadenoma 10.3 KRT7 CEACAM5
18 ovarian cystadenoma 10.3 KRT7 CEACAM5
19 warthin tumor 10.3 MAML2 KRT7
20 rectosigmoid junction neoplasm 10.3 KRT7 CEACAM5
21 transverse colon cancer 10.3 KRT7 CEACAM5
22 sigmoid neoplasm 10.3 KRT7 CEACAM5
23 mucoepidermoid esophageal carcinoma 10.3 KRT5 CEACAM5
24 krukenberg carcinoma 10.3 KRT7 CEACAM5
25 adenoid basal cell carcinoma 10.3 KRT7 CEACAM5
26 appendiceal neoplasm 10.3 KRT7 CEACAM5
27 colonic lymphangioma 10.3 KRT7 CEACAM5
28 breast cystic hypersecretory carcinoma 10.3 KRT5 CEACAM5
29 gallbladder squamous cell carcinoma 10.3 KRT5 CEACAM5
30 vulva basal cell carcinoma 10.3 KRT5 CEACAM5
31 biliary papillomatosis 10.3 KRT7 CEACAM5
32 lymphoepithelioma-like thymic carcinoma 10.3 NUTM1 KRT5
33 lung adenoid cystic carcinoma 10.3 MAML2 KRT7
34 liver sarcoma 10.3 KRT7 CEACAM5
35 anal canal paget's disease 10.3 PIP KRT7
36 pancreatic mucinous cystadenoma 10.3 KRT7 CEACAM5
37 gastric signet ring cell adenocarcinoma 10.3 PIP KRT7
38 colon leiomyosarcoma 10.3 KRT5 CEACAM5
39 bartholin's gland disease 10.3 PIP KRT7
40 bartholin's gland carcinoma 10.3 PIP KRT7
41 breast mucoepidermoid carcinoma 10.3 MAML2 KRT5
42 ovarian mucinous neoplasm 10.3 KRT7 CEACAM5
43 eyelid carcinoma 10.3 PIP KRT7
44 appendix disease 10.3 KRT7 CEACAM5
45 bowen's disease 10.3 KRT7 KRT10
46 appendix cancer 10.3 KRT7 CEACAM5
47 duodenum adenocarcinoma 10.3 KRT7 CEACAM5
48 erysipeloid 10.3 PIP KRT7
49 atrophoderma vermiculata 10.3 KRT15 CEACAM5
50 secretory meningioma 10.2 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Eccrine Sweat Gland Neoplasm:



Diseases related to Eccrine Sweat Gland Neoplasm

Symptoms & Phenotypes for Eccrine Sweat Gland Neoplasm

MGI Mouse Phenotypes related to Eccrine Sweat Gland Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.17 KRT14 KRT15 KRT17 KRT19 KRT5 PIP

Drugs & Therapeutics for Eccrine Sweat Gland Neoplasm

Search Clinical Trials , NIH Clinical Center for Eccrine Sweat Gland Neoplasm

Genetic Tests for Eccrine Sweat Gland Neoplasm

Anatomical Context for Eccrine Sweat Gland Neoplasm

MalaCards organs/tissues related to Eccrine Sweat Gland Neoplasm:

40
Breast, Skin, Lung, Colon, Liver, Thymus, Appendix

Publications for Eccrine Sweat Gland Neoplasm

Articles related to Eccrine Sweat Gland Neoplasm:

# Title Authors PMID Year
1
Malignant chondroid syringoma of the pinna. 61
26430319 2015
2
Primary mucinous carcinoma of the skin: the Mayo Clinic experience over the past 2 decades. 61
25627628 2015
3
A rare case of malignant chondroid syringoma of scalp. 61
23984246 2013
4
Aggressive digital papillary adenocarcinoma diagnosed by fine needle aspiration cytology. 61
21187879 2010
5
Aggressive digital papillary adenoma and adenocarcinoma. A clinicopathological study of 57 patients, with histochemical, immunopathological, and ultrastructural observations. 61
3301927 1987

Variations for Eccrine Sweat Gland Neoplasm

Expression for Eccrine Sweat Gland Neoplasm

Search GEO for disease gene expression data for Eccrine Sweat Gland Neoplasm.

Pathways for Eccrine Sweat Gland Neoplasm

Pathways related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 KRT7 KRT5 KRT19 KRT17 KRT15 KRT14
2 12.21 KRT7 KRT5 KRT19 KRT17 KRT10
3 11.79 KRT19 KRT17 KRT15 KRT14 KRT10
4
Show member pathways
11.62 KRT7 KRT5 KRT19 KRT17 KRT15 KRT14
5
Show member pathways
11.59 KRT7 KRT5 KRT19 KRT17 KRT14
6 11.49 KRT5 KRT17 KRT14
7 11.34 KRT19 KRT17 KRT15 KRT14 KRT10

GO Terms for Eccrine Sweat Gland Neoplasm

Cellular components related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 PIP KRT7 KRT5 KRT19 KRT15 KRT14
2 keratin filament GO:0045095 9.43 KRT7 KRT5 KRT14
3 cell periphery GO:0071944 9.33 KRT19 KRT17 KRT14
4 intermediate filament GO:0005882 9.17 KRT7 KRT5 KRT19 KRT17 KRT15 KRT14

Biological processes related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.5 KRT7 KRT5 KRT19 KRT17 KRT15 KRT14
2 epidermis development GO:0008544 9.43 KRT5 KRT15 KRT14
3 cornification GO:0070268 9.17 KRT7 KRT5 KRT19 KRT17 KRT15 KRT14
4 hemidesmosome assembly GO:0031581 9.16 KRT5 KRT14

Molecular functions related to Eccrine Sweat Gland Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.26 KRT5 KRT19 KRT15 KRT14
2 structural molecule activity GO:0005198 9.02 KRT19 KRT17 KRT15 KRT14 KRT10

Sources for Eccrine Sweat Gland Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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